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Found 2564 hits Enz. Inhib. hit(s) with Target = 'Cathepsin (H and K)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150349
PNG
(US8987249, 23 | US9713606, 23)
Show SMILES CC(C)(C)n1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C23H28FN5O/c1-23(2,3)29-13-17(12-26-29)14-4-5-15(20(24)10-14)8-19(11-25)28-22(30)21-16-6-7-18(9-16)27-21/h4-5,10,12-13,16,18-19,21,27H,6-9H2,1-3H3,(H,28,30)/t16-,18+,19-,21-/m0/s1
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n/an/a 3.80E+3n/an/an/an/a3.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150350
PNG
(US8987249, 24 | US9713606, 24)
Show SMILES CN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1F
Show InChI InChI=1S/C25H24F2N4O2/c1-31-20-10-13(2-3-14(20)11-21(31)32)19-7-5-15(22(26)23(19)27)8-18(12-28)30-25(33)24-16-4-6-17(9-16)29-24/h2-3,5,7,10,16-18,24,29H,4,6,8-9,11H2,1H3,(H,30,33)/t16-,17+,18-,24-/m0/s1
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n/an/a 1.33E+4n/an/an/an/a3.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150351
PNG
(US8987249, 25 | US9713606, 25)
Show SMILES Cc1ncc(s1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C20H21FN4OS/c1-11-23-10-18(27-11)13-3-2-12(17(21)8-13)6-16(9-22)25-20(26)19-14-4-5-15(7-14)24-19/h2-3,8,10,14-16,19,24H,4-7H2,1H3,(H,25,26)/t14-,15+,16-,19-/m0/s1
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n/an/a 6.30E+3n/an/an/an/a3.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150352
PNG
(US8987249, 26 | US9713606, 26)
Show SMILES CCn1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C21H24FN5O/c1-2-27-12-16(11-24-27)13-3-4-14(19(22)9-13)7-18(10-23)26-21(28)20-15-5-6-17(8-15)25-20/h3-4,9,11-12,15,17-18,20,25H,2,5-8H2,1H3,(H,26,28)/t15-,17+,18-,20-/m0/s1
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n/an/a 3.60E+3n/an/an/an/a3.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150353
PNG
(US8987249, 27 | US9713606, 27)
Show SMILES Cc1ccc(o1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C21H22FN3O2/c1-12-2-7-19(27-12)14-4-3-13(18(22)10-14)8-17(11-23)25-21(26)20-15-5-6-16(9-15)24-20/h2-4,7,10,15-17,20,24H,5-6,8-9H2,1H3,(H,25,26)/t15-,16+,17-,20-/m0/s1
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n/an/a 3.20E+3n/an/an/an/a3.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150354
PNG
(US8987249, 28 | US9713606, 28)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn(CC2CCCCO2)c1
Show InChI InChI=1S/C25H30FN5O2/c26-23-11-16(19-13-28-31(14-19)15-22-3-1-2-8-33-22)4-5-17(23)9-21(12-27)30-25(32)24-18-6-7-20(10-18)29-24/h4-5,11,13-14,18,20-22,24,29H,1-3,6-10,15H2,(H,30,32)/t18-,20+,21-,22?,24-/m0/s1
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n/an/a 2.70E+3n/an/an/an/a3.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150355
PNG
(US8987249, 29 | US9713606, 29)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2CC(=O)Nc2c1
Show InChI InChI=1S/C24H23FN4O2/c25-20-9-13(14-2-4-16-11-22(30)29-21(16)10-14)1-3-15(20)7-19(12-26)28-24(31)23-17-5-6-18(8-17)27-23/h1-4,9-10,17-19,23,27H,5-8,11H2,(H,28,31)(H,29,30)/t17-,18+,19-,23-/m0/s1
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n/an/a 1.40E+3n/an/an/an/a3.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150356
PNG
(US8987249, 30 | US9713606, 30)
Show SMILES CCCn1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C22H26FN5O/c1-2-7-28-13-17(12-25-28)14-3-4-15(20(23)10-14)8-19(11-24)27-22(29)21-16-5-6-18(9-16)26-21/h3-4,10,12-13,16,18-19,21,26H,2,5-9H2,1H3,(H,27,29)/t16-,18+,19-,21-/m0/s1
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n/an/a 3.10E+3n/an/an/an/a3.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM263602
PNG
(US9713606, 31)
Show SMILES CN1C(=O)Cc2ccc(cc12)-c1cc(F)c(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)cc1F
Show InChI InChI=1S/C25H24F2N4O2/c1-31-22-9-13(2-3-14(22)10-23(31)32)19-11-20(26)16(8-21(19)27)7-18(12-28)30-25(33)24-15-4-5-17(6-15)29-24/h2-3,8-9,11,15,17-18,24,29H,4-7,10H2,1H3,(H,30,33)/t15-,17+,18-,24-/m0/s1
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n/an/a 7.30E+3n/an/an/an/a3.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150358
PNG
(US8987249, 32 | US9713606, 32)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C26H30FN5O/c27-24-16-23(32-12-10-31(11-13-32)22-4-2-1-3-5-22)9-7-18(24)14-21(17-28)30-26(33)25-19-6-8-20(15-19)29-25/h1-5,7,9,16,19-21,25,29H,6,8,10-15H2,(H,30,33)/t19-,20+,21-,25-/m0/s1
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n/an/a 3.90E+3n/an/an/an/a3.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150359
PNG
(US8987249, 33 | US9713606, 33)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(s1)C(F)(F)F
Show InChI InChI=1S/C21H19F4N3OS/c22-16-9-12(17-5-6-18(30-17)21(23,24)25)2-1-11(16)7-15(10-26)28-20(29)19-13-3-4-14(8-13)27-19/h1-2,5-6,9,13-15,19,27H,3-4,7-8H2,(H,28,29)/t13-,14+,15-,19-/m0/s1
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n/an/a 4.80E+3n/an/an/an/a3.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150360
PNG
(US8987249, 34 | US9713606, 34)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2COC(=O)c2c1
Show InChI InChI=1S/C24H22FN3O3/c25-21-10-14(13-2-4-17-12-31-24(30)20(17)9-13)1-3-15(21)7-19(11-26)28-23(29)22-16-5-6-18(8-16)27-22/h1-4,9-10,16,18-19,22,27H,5-8,12H2,(H,28,29)/t16-,18+,19-,22-/m0/s1
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n/an/a 2.50E+3n/an/an/an/a3.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150361
PNG
(US8987249, 35 | US9713606, 35)
Show SMILES Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C23H20F2N4O/c24-20-9-13(14-2-4-17(11-26)21(25)10-14)1-3-15(20)7-19(12-27)29-23(30)22-16-5-6-18(8-16)28-22/h1-4,9-10,16,18-19,22,28H,5-8H2,(H,29,30)/t16-,18+,19?,22-/m0/s1
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n/an/a 4.40E+3n/an/an/an/a3.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150362
PNG
(US8987249, 36 | US9713606, 36)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cccs1
Show InChI InChI=1S/C20H20FN3OS/c21-17-10-13(18-2-1-7-26-18)4-3-12(17)8-16(11-22)24-20(25)19-14-5-6-15(9-14)23-19/h1-4,7,10,14-16,19,23H,5-6,8-9H2,(H,24,25)/t14-,15+,16-,19-/m0/s1
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n/an/a 3.00E+3n/an/an/an/a3.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM263608
PNG
(US9713606, 37)
Show SMILES NS(=O)(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C22H23FN4O3S/c23-20-11-14(13-2-1-3-19(10-13)31(25,29)30)4-5-15(20)8-18(12-24)27-22(28)21-16-6-7-17(9-16)26-21/h1-5,10-11,16-18,21,26H,6-9H2,(H,27,28)(H2,25,29,30)/t16-,17+,18-,21-/m0/s1
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n/an/a 5.10E+3n/an/an/an/a3.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150364
PNG
(US8987249, 38 | US9713606, 38)
Show SMILES CC(=O)NCCn1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C23H27FN6O2/c1-14(31)26-6-7-30-13-18(12-27-30)15-2-3-16(21(24)10-15)8-20(11-25)29-23(32)22-17-4-5-19(9-17)28-22/h2-3,10,12-13,17,19-20,22,28H,4-9H2,1H3,(H,26,31)(H,29,32)/t17-,19+,20-,22-/m0/s1
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n/an/a 2.90E+3n/an/an/an/a3.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150365
PNG
(US8987249, 39 | US9713606, 65)
Show SMILES Cc1c(cnn1C)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C21H24FN5O/c1-12-18(11-24-27(12)2)13-3-4-14(19(22)9-13)7-17(10-23)26-21(28)20-15-5-6-16(8-15)25-20/h3-4,9,11,15-17,20,25H,5-8H2,1-2H3,(H,26,28)/t15-,16+,17-,20-/m0/s1
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n/an/a 7.80E+3n/an/an/an/a3.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150366
PNG
(US8987249, 40 | US9713606, 40)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@H]2C[C@@H]1[C@@H]1C[C@H]21)C#N)-c1ccc(s1)C#N
Show InChI InChI=1S/C22H19FN4OS/c23-18-6-12(20-4-3-14(10-25)29-20)2-1-11(18)5-13(9-24)26-22(28)21-17-8-19(27-21)16-7-15(16)17/h1-4,6,13,15-17,19,21,27H,5,7-8H2,(H,26,28)/t13-,15+,16-,17+,19-,21-/m0/s1
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n/an/a 7.80E+3n/an/an/an/a3.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150367
PNG
(US8987249, 41 | US9713606, 41)
Show SMILES Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2C(=O)NCc2c1
Show InChI InChI=1S/C24H23FN4O2/c25-21-10-14(13-4-6-20-17(7-13)12-27-23(20)30)1-2-15(21)8-19(11-26)29-24(31)22-16-3-5-18(9-16)28-22/h1-2,4,6-7,10,16,18-19,22,28H,3,5,8-9,12H2,(H,27,30)(H,29,31)/t16-,18+,19?,22-/m0/s1
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n/an/a 4.70E+3n/an/an/an/a3.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150368
PNG
(US8987249, 42 | US9713606, 42)
Show SMILES CN1CCc2cc(ccc2C1=O)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C26H27FN4O2/c1-31-9-8-17-10-15(5-7-22(17)26(31)33)16-2-3-18(23(27)13-16)11-21(14-28)30-25(32)24-19-4-6-20(12-19)29-24/h2-3,5,7,10,13,19-21,24,29H,4,6,8-9,11-12H2,1H3,(H,30,32)/t19-,20+,21-,24-/m0/s1
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n/an/a 2.90E+3n/an/an/an/a3.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150369
PNG
(US8987249, 43 | US9713606, 43)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCN2CCOCC2C1
Show InChI InChI=1S/C23H30FN5O2/c24-21-11-19(29-6-5-28-7-8-31-14-20(28)13-29)4-2-15(21)9-18(12-25)27-23(30)22-16-1-3-17(10-16)26-22/h2,4,11,16-18,20,22,26H,1,3,5-10,13-14H2,(H,27,30)/t16-,17+,18-,20?,22-/m0/s1
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n/an/a 2.20E+3n/an/an/an/a3.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150370
PNG
(US8987249, 44 | US9713606, 44)
Show SMILES COCCn1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C22H26FN5O2/c1-30-7-6-28-13-17(12-25-28)14-2-3-15(20(23)10-14)8-19(11-24)27-22(29)21-16-4-5-18(9-16)26-21/h2-3,10,12-13,16,18-19,21,26H,4-9H2,1H3,(H,27,29)/t16-,18+,19-,21-/m0/s1
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n/an/a 4.00E+3n/an/an/an/a3.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150371
PNG
(US8987249, 45 | US9713606, 45)
Show SMILES Fc1cc(ccc1C[C@@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2ncsc2c1
Show InChI InChI=1S/C23H21FN4OS/c24-19-9-13(14-4-6-20-21(10-14)30-12-26-20)1-2-15(19)7-18(11-25)28-23(29)22-16-3-5-17(8-16)27-22/h1-2,4,6,9-10,12,16-18,22,27H,3,5,7-8H2,(H,28,29)/t16-,17+,18+,22-/m0/s1
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n/an/a 4.40E+3n/an/an/an/a3.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM263617
PNG
(US9713606, 46)
Show SMILES CCc1ccc(s1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C22H24FN3OS/c1-2-18-7-8-20(28-18)14-4-3-13(19(23)11-14)9-17(12-24)26-22(27)21-15-5-6-16(10-15)25-21/h3-4,7-8,11,15-17,21,25H,2,5-6,9-10H2,1H3,(H,26,27)/t15-,16+,17-,21-/m0/s1
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n/an/a 4.00E+3n/an/an/an/a3.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150373
PNG
(US8987249, 47 | US9713606, 47)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-n1cc(COc2ccccc2)nn1
Show InChI InChI=1S/C25H25FN6O2/c26-23-12-21(32-14-20(30-31-32)15-34-22-4-2-1-3-5-22)9-7-16(23)10-19(13-27)29-25(33)24-17-6-8-18(11-17)28-24/h1-5,7,9,12,14,17-19,24,28H,6,8,10-11,15H2,(H,29,33)/t17-,18+,19-,24-/m0/s1
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n/an/a 3.40E+3n/an/an/an/a3.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150374
PNG
(US8987249, 48 | US9713606, 48)
Show SMILES CC(C)CC(=O)n1cc(cn1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C24H28FN5O2/c1-14(2)7-22(31)30-13-18(12-27-30)15-3-4-16(21(25)10-15)8-20(11-26)29-24(32)23-17-5-6-19(9-17)28-23/h3-4,10,12-14,17,19-20,23,28H,5-9H2,1-2H3,(H,29,32)/t17-,19+,20-,23-/m0/s1
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n/an/a 3.30E+3n/an/an/an/a3.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150375
PNG
(US8987249, 49 | US9713606, 49)
Show SMILES Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2C(=O)NCCc2c1
Show InChI InChI=1S/C25H25FN4O2/c26-22-12-15(14-4-6-21-16(9-14)7-8-28-24(21)31)1-2-17(22)10-20(13-27)30-25(32)23-18-3-5-19(11-18)29-23/h1-2,4,6,9,12,18-20,23,29H,3,5,7-8,10-11H2,(H,28,31)(H,30,32)/t18-,19+,20?,23-/m0/s1
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n/an/a 6.50E+3n/an/an/an/a3.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150376
PNG
(US8987249, 50 | US9713606, 50)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn(CC2CCCO2)c1
Show InChI InChI=1S/C24H28FN5O2/c25-22-10-15(18-12-27-30(13-18)14-21-2-1-7-32-21)3-4-16(22)8-20(11-26)29-24(31)23-17-5-6-19(9-17)28-23/h3-4,10,12-13,17,19-21,23,28H,1-2,5-9,14H2,(H,29,31)/t17-,19+,20-,21?,23-/m0/s1
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n/an/a 3.60E+3n/an/an/an/a3.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150377
PNG
(US8987249, 51 | US9713606, 51)
Show SMILES CNS(=O)(=O)c1ccc(cc1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C23H25FN4O3S/c1-26-32(30,31)20-8-5-14(6-9-20)15-2-3-16(21(24)12-15)10-19(13-25)28-23(29)22-17-4-7-18(11-17)27-22/h2-3,5-6,8-9,12,17-19,22,26-27H,4,7,10-11H2,1H3,(H,28,29)/t17-,18+,19?,22-/m0/s1
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n/an/a 4.90E+3n/an/an/an/a3.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150378
PNG
(US8987249, 52 | US9713606, 52)
Show SMILES CS(=O)(=O)c1cc(ccc1C#N)-c1cc(F)c(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C24H22F2N4O3S/c1-34(32,33)22-9-13(2-3-15(22)11-27)16-7-20(25)19(21(26)8-16)10-18(12-28)30-24(31)23-14-4-5-17(6-14)29-23/h2-3,7-9,14,17-18,23,29H,4-6,10H2,1H3,(H,30,31)/t14-,17+,18?,23-/m0/s1
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n/an/a 1.70E+4n/an/an/an/a3.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150379
PNG
(US8987249, 53 | US9713606, 53)
Show SMILES NC(=O)c1cccc(c1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C23H23FN4O2/c24-20-11-14(13-2-1-3-17(8-13)22(26)29)4-5-15(20)9-19(12-25)28-23(30)21-16-6-7-18(10-16)27-21/h1-5,8,11,16,18-19,21,27H,6-7,9-10H2,(H2,26,29)(H,28,30)/t16-,18+,19?,21-/m0/s1
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n/an/a 4.10E+3n/an/an/an/a3.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150380
PNG
(US8987249, 54 | US9713606, 54)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C23H24FN3O3S/c1-31(29,30)20-8-5-14(6-9-20)15-2-3-16(21(24)12-15)10-19(13-25)27-23(28)22-17-4-7-18(11-17)26-22/h2-3,5-6,8-9,12,17-19,22,26H,4,7,10-11H2,1H3,(H,27,28)/t17-,18+,19?,22-/m0/s1
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n/an/a 4.50E+3n/an/an/an/a3.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150381
PNG
(US8987249, 55 | US9713606, 55)
Show SMILES CC(=O)N1CCC(Cn2cc(cn2)-c2ccc(C[C@H](NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)c(F)c2)CC1
Show InChI InChI=1S/C27H33FN6O2/c1-17(35)33-8-6-18(7-9-33)15-34-16-22(14-30-34)19-2-3-20(25(28)12-19)10-24(13-29)32-27(36)26-21-4-5-23(11-21)31-26/h2-3,12,14,16,18,21,23-24,26,31H,4-11,15H2,1H3,(H,32,36)/t21-,23+,24-,26-/m0/s1
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n/an/a 3.90E+3n/an/an/an/a3.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150382
PNG
(US8987249, 56 | US9713606, 56)
Show SMILES NS(=O)(=O)c1ccc(cc1)-c1ccc(CC(NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C22H23FN4O3S/c23-20-11-14(13-4-7-19(8-5-13)31(25,29)30)1-2-15(20)9-18(12-24)27-22(28)21-16-3-6-17(10-16)26-21/h1-2,4-5,7-8,11,16-18,21,26H,3,6,9-10H2,(H,27,28)(H2,25,29,30)/t16-,17+,18?,21-/m0/s1
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n/an/a 4.00E+3n/an/an/an/a3.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin K


(Homo sapiens (human))
BDBM138142
PNG
(US8877967, 3)
Show SMILES CN(N=C(c1ccccc1)c1cccc(c1)C(=O)c1ccccc1)C(N)=S
Show InChI InChI=1S/C22H19N3OS/c1-25(22(23)27)24-20(16-9-4-2-5-10-16)18-13-8-14-19(15-18)21(26)17-11-6-3-7-12-17/h2-15H,1H3,(H2,23,27)/b24-20+
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n/an/a 17.4n/an/an/an/a3.525



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Recombinant human procathepsin K was obtained from Enzo Life Sciences. Activation of the proenzyme was performed in 32.5 mM sodium acetate pH 3.5, ED...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Cathepsin K


(Homo sapiens (human))
BDBM138144
PNG
(US8877967, 9)
Show SMILES Cc1cccc(c1)C(=O)c1cccc(c1)C(=NNC(N)=S)c1cccc(C)c1
Show InChI InChI=1S/C23H21N3OS/c1-15-6-3-8-17(12-15)21(25-26-23(24)28)18-9-5-11-20(14-18)22(27)19-10-4-7-16(2)13-19/h3-14H,1-2H3,(H3,24,26,28)/b25-21+
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n/an/a 1.03E+3n/an/an/an/a3.525



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Recombinant human procathepsin K was obtained from Enzo Life Sciences. Activation of the proenzyme was performed in 32.5 mM sodium acetate pH 3.5, ED...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Cathepsin K


(Homo sapiens (human))
BDBM138146
PNG
(US8877967, 13)
Show SMILES NC(=S)NN=C(c1ccc(F)cc1)c1cccc(c1)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C21H15F2N3OS/c22-17-8-4-13(5-9-17)19(25-26-21(24)28)15-2-1-3-16(12-15)20(27)14-6-10-18(23)11-7-14/h1-12H,(H3,24,26,28)/b25-19-
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n/an/a 8.50E+3n/an/an/an/a3.525



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Recombinant human procathepsin K was obtained from Enzo Life Sciences. Activation of the proenzyme was performed in 32.5 mM sodium acetate pH 3.5, ED...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Cathepsin K


(Homo sapiens (human))
BDBM138148
PNG
(US8877967, 18)
Show SMILES COc1ccc(cc1)C(=O)c1cccc(c1)C(=NNC(N)=S)c1ccc(O)cc1
Show InChI InChI=1S/C22H19N3O3S/c1-28-19-11-7-15(8-12-19)21(27)17-4-2-3-16(13-17)20(24-25-22(23)29)14-5-9-18(26)10-6-14/h2-13,26H,1H3,(H3,23,25,29)/b24-20-
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n/an/a 6.16E+3n/an/an/an/a3.525



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Recombinant human procathepsin K was obtained from Enzo Life Sciences. Activation of the proenzyme was performed in 32.5 mM sodium acetate pH 3.5, ED...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Cathepsin K


(Homo sapiens (human))
BDBM138149
PNG
(US8877967, 17)
Show SMILES COc1ccc(cc1)C(=NNC(N)=S)c1cccc(c1)C(=O)c1ccc(O)cc1
Show InChI InChI=1S/C22H19N3O3S/c1-28-19-11-7-14(8-12-19)20(24-25-22(23)29)16-3-2-4-17(13-16)21(27)15-5-9-18(26)10-6-15/h2-13,26H,1H3,(H3,23,25,29)/b24-20-
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n/an/a 6.16E+3n/an/an/an/a3.525



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Recombinant human procathepsin K was obtained from Enzo Life Sciences. Activation of the proenzyme was performed in 32.5 mM sodium acetate pH 3.5, ED...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Cathepsin K


(Homo sapiens (human))
BDBM138147
PNG
(US8877967, 19)
Show SMILES COc1ccc(cc1)C(=NNC(N)=S)c1cccc(c1)C(=NNC(N)=S)c1ccc(O)cc1
Show InChI InChI=1S/C23H22N6O2S2/c1-31-19-11-7-15(8-12-19)21(27-29-23(25)33)17-4-2-3-16(13-17)20(26-28-22(24)32)14-5-9-18(30)10-6-14/h2-13,30H,1H3,(H3,24,28,32)(H3,25,29,33)/b26-20+,27-21-
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n/an/a 6.16E+3n/an/an/an/a3.525



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Recombinant human procathepsin K was obtained from Enzo Life Sciences. Activation of the proenzyme was performed in 32.5 mM sodium acetate pH 3.5, ED...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Cathepsin K


(Homo sapiens (human))
BDBM138149
PNG
(US8877967, 17)
Show SMILES COc1ccc(cc1)C(=NNC(N)=S)c1cccc(c1)C(=O)c1ccc(O)cc1
Show InChI InChI=1S/C22H19N3O3S/c1-28-19-11-7-14(8-12-19)20(24-25-22(23)29)16-3-2-4-17(13-16)21(27)15-5-9-18(26)10-6-15/h2-13,26H,1H3,(H3,23,25,29)/b24-20-
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n/an/a 3.20E+3n/an/an/an/a3.525



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Recombinant human procathepsin K was obtained from Enzo Life Sciences. Activation of the proenzyme was performed in 32.5 mM sodium acetate pH 3.5, ED...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Cathepsin K


(Homo sapiens (human))
BDBM138148
PNG
(US8877967, 18)
Show SMILES COc1ccc(cc1)C(=O)c1cccc(c1)C(=NNC(N)=S)c1ccc(O)cc1
Show InChI InChI=1S/C22H19N3O3S/c1-28-19-11-7-15(8-12-19)21(27)17-4-2-3-16(13-17)20(24-25-22(23)29)14-5-9-18(26)10-6-14/h2-13,26H,1H3,(H3,23,25,29)/b24-20-
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n/an/a 3.20E+3n/an/an/an/a3.525



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Recombinant human procathepsin K was obtained from Enzo Life Sciences. Activation of the proenzyme was performed in 32.5 mM sodium acetate pH 3.5, ED...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Cathepsin K


(Homo sapiens (human))
BDBM138147
PNG
(US8877967, 19)
Show SMILES COc1ccc(cc1)C(=NNC(N)=S)c1cccc(c1)C(=NNC(N)=S)c1ccc(O)cc1
Show InChI InChI=1S/C23H22N6O2S2/c1-31-19-11-7-15(8-12-19)21(27-29-23(25)33)17-4-2-3-16(13-17)20(26-28-22(24)32)14-5-9-18(30)10-6-14/h2-13,30H,1H3,(H3,24,28,32)(H3,25,29,33)/b26-20+,27-21-
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n/an/a 3.20E+3n/an/an/an/a3.525



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Recombinant human procathepsin K was obtained from Enzo Life Sciences. Activation of the proenzyme was performed in 32.5 mM sodium acetate pH 3.5, ED...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Cathepsin K


(Homo sapiens (human))
BDBM138152
PNG
(US8877967, 23)
Show SMILES CC(C)Oc1ccc(cc1)C(=NNC(N)=S)c1cccc(c1)C(=NNC(N)=S)c1ccc(OC(C)C)cc1
Show InChI InChI=1S/C28H32N6O2S2/c1-17(2)35-23-12-8-19(9-13-23)25(31-33-27(29)37)21-6-5-7-22(16-21)26(32-34-28(30)38)20-10-14-24(15-11-20)36-18(3)4/h5-18H,1-4H3,(H3,29,33,37)(H3,30,34,38)/b31-25-,32-26+
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n/an/a>1.00E+4n/an/an/an/a3.525



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Recombinant human procathepsin K was obtained from Enzo Life Sciences. Activation of the proenzyme was performed in 32.5 mM sodium acetate pH 3.5, ED...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Cathepsin K


(Homo sapiens (human))
BDBM138153
PNG
(US8877967, 24)
Show SMILES NC(=S)NN=C(c1ccc(Br)cc1)c1cccc(c1)C(=NNC(N)=S)c1ccc(Br)cc1
Show InChI InChI=1S/C22H18Br2N6S2/c23-17-8-4-13(5-9-17)19(27-29-21(25)31)15-2-1-3-16(12-15)20(28-30-22(26)32)14-6-10-18(24)11-7-14/h1-12H,(H3,25,29,31)(H3,26,30,32)/b27-19-,28-20+
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n/an/a>1.00E+4n/an/an/an/a3.525



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Recombinant human procathepsin K was obtained from Enzo Life Sciences. Activation of the proenzyme was performed in 32.5 mM sodium acetate pH 3.5, ED...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Cathepsin K


(Homo sapiens (human))
BDBM138154
PNG
(US8877967, 25)
Show SMILES NC(=S)NN=C(c1ccccc1)c1cc(cc(c1)C(=O)c1ccccc1)C(=O)c1ccccc1
Show InChI InChI=1S/C28H21N3O2S/c29-28(34)31-30-25(19-10-4-1-5-11-19)22-16-23(26(32)20-12-6-2-7-13-20)18-24(17-22)27(33)21-14-8-3-9-15-21/h1-18H,(H3,29,31,34)/b30-25-
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n/an/a 2.80E+3n/an/an/an/a3.525



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Recombinant human procathepsin K was obtained from Enzo Life Sciences. Activation of the proenzyme was performed in 32.5 mM sodium acetate pH 3.5, ED...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Cathepsin K


(Homo sapiens (human))
BDBM138150
PNG
(US8877967, 33)
Show SMILES COc1ccc(cc1)C(=NNC(N)=S)c1cccc(c1)C(=NNC(N)=S)c1ccc(OC)cc1
Show InChI InChI=1S/C24H24N6O2S2/c1-31-19-10-6-15(7-11-19)21(27-29-23(25)33)17-4-3-5-18(14-17)22(28-30-24(26)34)16-8-12-20(32-2)13-9-16/h3-14H,1-2H3,(H3,25,29,33)(H3,26,30,34)/b27-21-,28-22+
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n/an/a 2.11E+3n/an/an/an/a3.525



OXiGENE, Inc.; Baylor University

US Patent


Assay Description
Recombinant human procathepsin K was obtained from Enzo Life Sciences. Activation of the proenzyme was performed in 32.5 mM sodium acetate pH 3.5, ED...


US Patent US8877967 (2014)


BindingDB Entry DOI: 10.7270/Q25H7F0C
More data for this
Ligand-Target Pair
Cathepsin K


(Homo sapiens (human))
BDBM138492
PNG
(US8877775, 1 | US9073869, 1)
Show SMILES CS(=O)(=O)c1cc(ccc1C#N)-c1ccc(C[C@H](NC(=O)[C@H]2NC3CCC2CC3)C#N)c(F)c1
Show InChI InChI=1S/C25H25FN4O3S/c1-34(32,33)23-12-17(3-5-19(23)13-27)16-2-4-18(22(26)11-16)10-21(14-28)30-25(31)24-15-6-8-20(29-24)9-7-15/h2-5,11-12,15,20-21,24,29H,6-10H2,1H3,(H,30,31)/t15?,20?,21-,24-/m0/s1
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n/an/a 2.70E+3n/an/an/an/a3.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The following buffers were used: Activation buffer: 32.5 mM sodium acetate, adjusted to pH 3.5 with HCl; Assay buffer: 150 mM sodium acetate, 4mM EDT...


US Patent US8877775 (2014)


BindingDB Entry DOI: 10.7270/Q20R9N3T
More data for this
Ligand-Target Pair
Cathepsin K


(Homo sapiens (human))
BDBM138493
PNG
(US8877775, 2 | US9073869, 2)
Show SMILES O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2CC(=O)Nc2c1)C#N)[C@H]1NC2CCC1CC2
Show InChI InChI=1S/C25H26N4O2/c26-14-21(28-25(31)24-17-7-9-20(27-24)10-8-17)11-15-1-3-16(4-2-15)18-5-6-19-13-23(30)29-22(19)12-18/h1-6,12,17,20-21,24,27H,7-11,13H2,(H,28,31)(H,29,30)/t17?,20?,21-,24-/m0/s1
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n/an/a 4.20E+3n/an/an/an/a3.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The following buffers were used: Activation buffer: 32.5 mM sodium acetate, adjusted to pH 3.5 with HCl; Assay buffer: 150 mM sodium acetate, 4mM EDT...


US Patent US8877775 (2014)


BindingDB Entry DOI: 10.7270/Q20R9N3T
More data for this
Ligand-Target Pair
Cathepsin K


(Homo sapiens (human))
BDBM138494
PNG
(US8877775, 4 | US9073869, 4)
Show SMILES CN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@H]3CC[C@@H]2CC3)C#N)cc1
Show InChI InChI=1S/C26H28N4O2/c1-30-23-13-19(6-7-20(23)14-24(30)31)17-4-2-16(3-5-17)12-22(15-27)29-26(32)25-18-8-10-21(28-25)11-9-18/h2-7,13,18,21-22,25,28H,8-12,14H2,1H3,(H,29,32)/t18-,21+,22-,25-/m0/s1
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n/an/a 6.30E+3n/an/an/an/a3.525



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The following buffers were used: Activation buffer: 32.5 mM sodium acetate, adjusted to pH 3.5 with HCl; Assay buffer: 150 mM sodium acetate, 4mM EDT...


US Patent US8877775 (2014)


BindingDB Entry DOI: 10.7270/Q20R9N3T
More data for this
Ligand-Target Pair
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