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Found 5003 hits Enz. Inhib. hit(s) with Target = 'Cereblon/Histone deacetylase 6'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM24622
PNG
(3-[(dimethylamino)methyl]-N-{2-[4-(hydroxycarbamoy...)
Show SMILES CN(C)Cc1c(oc2ccccc12)C(=O)NCCOc1ccc(cc1)C(=O)NO
Show InChI InChI=1S/C21H23N3O5/c1-24(2)13-17-16-5-3-4-6-18(16)29-19(17)21(26)22-11-12-28-15-9-7-14(8-10-15)20(25)23-27/h3-10,27H,11-13H2,1-2H3,(H,22,26)(H,23,25)
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PubMed
17 -43.9n/an/an/an/an/a7.422



Celera Genomics



Assay Description
HDAC activity was measured using a continuous trypsin-coupled assay. For inhibitor characterization, measurements were done using 96-well assay plat...


Mol Cancer Ther 5: 1309-17 (2006)


Article DOI: 10.1158/1535-7163.MCT-05-0442
BindingDB Entry DOI: 10.7270/Q2DF6PJJ
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM19149
PNG
(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccccc1
Show InChI InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
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21 -43.4n/an/an/an/an/a7.422



University of Notre Dame



Assay Description
To assess the effect of test compounds on histone deacetylase enzyme function in Vitro, a fluorometric assay was performed using HDAC, which incubate...


J Med Chem 51: 2898-906 (2008)


Article DOI: 10.1021/jm7015254
BindingDB Entry DOI: 10.7270/Q2NC5ZG2
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM22450
PNG
(N-hydroxy-N -(4-{(2R,4S,6R)-4-phenyl-6-[(pyridin-4...)
Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccc(cc1)[C@H]1O[C@@H](CSc2ccncc2)C[C@H](O1)c1ccccc1
Show InChI InChI=1S/C30H35N3O5S/c34-28(10-6-1-2-7-11-29(35)33-36)32-24-14-12-23(13-15-24)30-37-25(21-39-26-16-18-31-19-17-26)20-27(38-30)22-8-4-3-5-9-22/h3-5,8-9,12-19,25,27,30,36H,1-2,6-7,10-11,20-21H2,(H,32,34)(H,33,35)/t25-,27+,30+/m1/s1
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28 -42.7n/an/an/an/an/a7.422



University of Notre Dame



Assay Description
To assess the effect of test compounds on histone deacetylase enzyme function in Vitro, a fluorometric assay was performed using HDAC, which incubate...


J Med Chem 51: 2898-906 (2008)


Article DOI: 10.1021/jm7015254
BindingDB Entry DOI: 10.7270/Q2NC5ZG2
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM22449
PNG
(CHEMBL356769 | N-(4-{(2R,4R,6S)-4-{[(4,5-diphenyl-...)
Show SMILES OCc1ccc(cc1)[C@@H]1C[C@H](CSc2nc(c(o2)-c2ccccc2)-c2ccccc2)O[C@@H](O1)c1ccc(NC(=O)CCCCCCC(=O)NO)cc1
Show InChI InChI=1S/C41H43N3O7S/c45-26-28-17-19-29(20-18-28)35-25-34(27-52-41-43-38(30-11-5-3-6-12-30)39(51-41)31-13-7-4-8-14-31)49-40(50-35)32-21-23-33(24-22-32)42-36(46)15-9-1-2-10-16-37(47)44-48/h3-8,11-14,17-24,34-35,40,45,48H,1-2,9-10,15-16,25-27H2,(H,42,46)(H,44,47)/t34-,35+,40+/m1/s1
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142 -38.7n/an/an/an/an/a7.422



University of Notre Dame



Assay Description
To assess the effect of test compounds on histone deacetylase enzyme function in Vitro, a fluorometric assay was performed using HDAC, which incubate...


J Med Chem 51: 2898-906 (2008)


Article DOI: 10.1021/jm7015254
BindingDB Entry DOI: 10.7270/Q2NC5ZG2
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM249364
PNG
(US9464073, 001 | US9884850, Compound 1)
Show SMILES ONC(=O)c1cnc(NC2(CCCCC2)c2cc(F)cc(F)c2)nc1
Show InChI InChI=1S/C17H18F2N4O2/c18-13-6-12(7-14(19)8-13)17(4-2-1-3-5-17)22-16-20-9-11(10-21-16)15(24)23-25/h6-10,25H,1-5H2,(H,23,24)(H,20,21,22)
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n/an/a 2.90n/an/an/an/a7.425



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9464073 (2016)


BindingDB Entry DOI: 10.7270/Q2TD9W8Z
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM249365
PNG
(US9464073, 002 | US9884850, Compound 2)
Show SMILES ONC(=O)c1cnc(NC2(CCOCC2)c2cc(F)ccc2F)nc1
Show InChI InChI=1S/C16H16F2N4O3/c17-11-1-2-13(18)12(7-11)16(3-5-25-6-4-16)21-15-19-8-10(9-20-15)14(23)22-24/h1-2,7-9,24H,3-6H2,(H,22,23)(H,19,20,21)
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n/an/a 2.40n/an/an/an/a7.425



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9464073 (2016)


BindingDB Entry DOI: 10.7270/Q2TD9W8Z
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM249366
PNG
(US9464073, 003 | US9884850, Compound 3)
Show SMILES ONC(=O)c1cnc(NC2(CCC(F)(F)CC2)c2ccccc2)nc1
Show InChI InChI=1S/C17H18F2N4O2/c18-17(19)8-6-16(7-9-17,13-4-2-1-3-5-13)22-15-20-10-12(11-21-15)14(24)23-25/h1-5,10-11,25H,6-9H2,(H,23,24)(H,20,21,22)
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n/an/a 3.70n/an/an/an/a7.425



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9464073 (2016)


BindingDB Entry DOI: 10.7270/Q2TD9W8Z
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM249367
PNG
(US9464073, 004 | US9884850, Compound 4)
Show SMILES ONC(=O)c1cnc(NC2(CCC3(CC2)OCCO3)c2cccc(F)c2)nc1
Show InChI InChI=1S/C19H21FN4O4/c20-15-3-1-2-14(10-15)18(4-6-19(7-5-18)27-8-9-28-19)23-17-21-11-13(12-22-17)16(25)24-26/h1-3,10-12,26H,4-9H2,(H,24,25)(H,21,22,23)
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n/an/a 3.90n/an/an/an/a7.425



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9464073 (2016)


BindingDB Entry DOI: 10.7270/Q2TD9W8Z
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM249364
PNG
(US9464073, 001 | US9884850, Compound 1)
Show SMILES ONC(=O)c1cnc(NC2(CCCCC2)c2cc(F)cc(F)c2)nc1
Show InChI InChI=1S/C17H18F2N4O2/c18-13-6-12(7-14(19)8-13)17(4-2-1-3-5-17)22-16-20-9-11(10-21-16)15(24)23-25/h6-10,25H,1-5H2,(H,23,24)(H,20,21,22)
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n/an/a 2.90n/an/an/an/a7.425



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9884850 (2018)


BindingDB Entry DOI: 10.7270/Q2CZ3967
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM249365
PNG
(US9464073, 002 | US9884850, Compound 2)
Show SMILES ONC(=O)c1cnc(NC2(CCOCC2)c2cc(F)ccc2F)nc1
Show InChI InChI=1S/C16H16F2N4O3/c17-11-1-2-13(18)12(7-11)16(3-5-25-6-4-16)21-15-19-8-10(9-20-15)14(23)22-24/h1-2,7-9,24H,3-6H2,(H,22,23)(H,19,20,21)
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n/an/a 2.40n/an/an/an/a7.425



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9884850 (2018)


BindingDB Entry DOI: 10.7270/Q2CZ3967
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM249366
PNG
(US9464073, 003 | US9884850, Compound 3)
Show SMILES ONC(=O)c1cnc(NC2(CCC(F)(F)CC2)c2ccccc2)nc1
Show InChI InChI=1S/C17H18F2N4O2/c18-17(19)8-6-16(7-9-17,13-4-2-1-3-5-13)22-15-20-10-12(11-21-15)14(24)23-25/h1-5,10-11,25H,6-9H2,(H,23,24)(H,20,21,22)
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n/an/a 3.70n/an/an/an/a7.425



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9884850 (2018)


BindingDB Entry DOI: 10.7270/Q2CZ3967
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM249367
PNG
(US9464073, 004 | US9884850, Compound 4)
Show SMILES ONC(=O)c1cnc(NC2(CCC3(CC2)OCCO3)c2cccc(F)c2)nc1
Show InChI InChI=1S/C19H21FN4O4/c20-15-3-1-2-14(10-15)18(4-6-19(7-5-18)27-8-9-28-19)23-17-21-11-13(12-22-17)16(25)24-26/h1-3,10-12,26H,4-9H2,(H,24,25)(H,21,22,23)
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n/an/a 3.90n/an/an/an/a7.425



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9884850 (2018)


BindingDB Entry DOI: 10.7270/Q2CZ3967
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM213171
PNG
(US9278963, 018)
Show SMILES ONC(=O)c1cnc(NC2(CCN(CC2)S(=O)(=O)c2cccc(F)c2)c2ccccc2)nc1
Show InChI InChI=1S/C22H22FN5O4S/c23-18-7-4-8-19(13-18)33(31,32)28-11-9-22(10-12-28,17-5-2-1-3-6-17)26-21-24-14-16(15-25-21)20(29)27-30/h1-8,13-15,30H,9-12H2,(H,27,29)(H,24,25,26)
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n/an/a 5.10n/an/an/an/a7.425



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...


US Patent US9278963 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M0K
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM213172
PNG
(US9278963, 019)
Show SMILES ONC(=O)c1cnc(NC2(CCN(CC2)S(=O)(=O)c2ccc(Cl)cc2)c2ccccc2)nc1
Show InChI InChI=1S/C22H22ClN5O4S/c23-18-6-8-19(9-7-18)33(31,32)28-12-10-22(11-13-28,17-4-2-1-3-5-17)26-21-24-14-16(15-25-21)20(29)27-30/h1-9,14-15,30H,10-13H2,(H,27,29)(H,24,25,26)
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n/an/a 5n/an/an/an/a7.425



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...


US Patent US9278963 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M0K
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM213173
PNG
(US9278963, 020)
Show SMILES Cc1ccccc1S(=O)(=O)N1CCC(CC1)(Nc1ncc(cn1)C(=O)NO)c1ccccc1
Show InChI InChI=1S/C23H25N5O4S/c1-17-7-5-6-10-20(17)33(31,32)28-13-11-23(12-14-28,19-8-3-2-4-9-19)26-22-24-15-18(16-25-22)21(29)27-30/h2-10,15-16,30H,11-14H2,1H3,(H,27,29)(H,24,25,26)
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n/an/a 4.5n/an/an/an/a7.425



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...


US Patent US9278963 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M0K
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM213174
PNG
(US9278963, 021)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCC(CC1)(Nc1ncc(cn1)C(=O)NO)c1ccccc1
Show InChI InChI=1S/C23H25N5O4S/c1-17-7-9-20(10-8-17)33(31,32)28-13-11-23(12-14-28,19-5-3-2-4-6-19)26-22-24-15-18(16-25-22)21(29)27-30/h2-10,15-16,30H,11-14H2,1H3,(H,27,29)(H,24,25,26)
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n/an/a 4.5n/an/an/an/a7.425



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...


US Patent US9278963 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M0K
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM213175
PNG
(US9278963, 022)
Show SMILES ONC(=O)c1cnc(NC2(CCN(CC2)S(=O)(=O)c2ccc(cc2)C(F)(F)F)c2ccccc2)nc1
Show InChI InChI=1S/C23H22F3N5O4S/c24-23(25,26)18-6-8-19(9-7-18)36(34,35)31-12-10-22(11-13-31,17-4-2-1-3-5-17)29-21-27-14-16(15-28-21)20(32)30-33/h1-9,14-15,33H,10-13H2,(H,30,32)(H,27,28,29)
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n/an/a 7.30n/an/an/an/a7.425



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...


US Patent US9278963 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M0K
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM213176
PNG
(US9278963, 023)
Show SMILES ONC(=O)c1cnc(NC2(CCN(CC2)S(=O)(=O)c2ccccc2)c2ccccc2)nc1
Show InChI InChI=1S/C22H23N5O4S/c28-20(26-29)17-15-23-21(24-16-17)25-22(18-7-3-1-4-8-18)11-13-27(14-12-22)32(30,31)19-9-5-2-6-10-19/h1-10,15-16,29H,11-14H2,(H,26,28)(H,23,24,25)
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n/an/a 4.60n/an/an/an/a7.425



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...


US Patent US9278963 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M0K
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM213177
PNG
(US9278963, 024)
Show SMILES ONC(=O)c1cnc(NC2(CCN(CC2)C(=O)Nc2c(F)cccc2F)c2ccccc2)nc1
Show InChI InChI=1S/C23H22F2N6O3/c24-17-7-4-8-18(25)19(17)28-22(33)31-11-9-23(10-12-31,16-5-2-1-3-6-16)29-21-26-13-15(14-27-21)20(32)30-34/h1-8,13-14,34H,9-12H2,(H,28,33)(H,30,32)(H,26,27,29)
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n/an/a 3.70n/an/an/an/a7.425



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...


US Patent US9278963 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M0K
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM213183
PNG
(US9278963, 025)
Show SMILES CC(C)[C@@H](C(=O)N1CCC(CC1)(Nc1ncc(cn1)C(=O)NO)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H31N5O3/c1-19(2)23(20-9-5-3-6-10-20)25(34)32-15-13-27(14-16-32,22-11-7-4-8-12-22)30-26-28-17-21(18-29-26)24(33)31-35/h3-12,17-19,23,35H,13-16H2,1-2H3,(H,31,33)(H,28,29,30)/t23-/m1/s1
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n/an/a 13n/an/an/an/a7.425



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...


US Patent US9278963 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M0K
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM213178
PNG
(US9278963, 026)
Show SMILES CC(C)[C@H](C(=O)N1CCC(CC1)(Nc1ncc(cn1)C(=O)NO)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H31N5O3/c1-19(2)23(20-9-5-3-6-10-20)25(34)32-15-13-27(14-16-32,22-11-7-4-8-12-22)30-26-28-17-21(18-29-26)24(33)31-35/h3-12,17-19,23,35H,13-16H2,1-2H3,(H,31,33)(H,28,29,30)/t23-/m0/s1
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n/an/a 5n/an/an/an/a7.425



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...


US Patent US9278963 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M0K
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM213184
PNG
(US9278963, 027)
Show SMILES C[C@@H](C(=O)N1CCC(C)(CC1)Nc1ncc(cn1)C(=O)NO)c1ccccc1
Show InChI InChI=1S/C20H25N5O3/c1-14(15-6-4-3-5-7-15)18(27)25-10-8-20(2,9-11-25)23-19-21-12-16(13-22-19)17(26)24-28/h3-7,12-14,28H,8-11H2,1-2H3,(H,24,26)(H,21,22,23)/t14-/m1/s1
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n/an/a 12n/an/an/an/a7.425



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...


US Patent US9278963 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M0K
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM213179
PNG
(US9278963, 028)
Show SMILES ONC(=O)c1cnc(NC2(CCN(CC2)C(=O)Cc2c[nH]c3ccccc23)c2ccccc2)nc1
Show InChI InChI=1S/C26H26N6O3/c33-23(14-18-15-27-22-9-5-4-8-21(18)22)32-12-10-26(11-13-32,20-6-2-1-3-7-20)30-25-28-16-19(17-29-25)24(34)31-35/h1-9,15-17,27,35H,10-14H2,(H,31,34)(H,28,29,30)
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n/an/a 2.80n/an/an/an/a7.425



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...


US Patent US9278963 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M0K
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM213180
PNG
(US9278963, 029)
Show SMILES CC(C)C[C@H](C(=O)N1CCC(CC1)(Nc1ncc(cn1)C(=O)NO)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H33N5O3/c1-20(2)17-24(21-9-5-3-6-10-21)26(35)33-15-13-28(14-16-33,23-11-7-4-8-12-23)31-27-29-18-22(19-30-27)25(34)32-36/h3-12,18-20,24,36H,13-17H2,1-2H3,(H,32,34)(H,29,30,31)/t24-/m0/s1
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n/an/a 11n/an/an/an/a7.425



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...


US Patent US9278963 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M0K
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM213185
PNG
(US9278963, 030)
Show SMILES CC(C)C[C@@H](C(=O)N1CCC(CC1)(Nc1ncc(cn1)C(=O)NO)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H33N5O3/c1-20(2)17-24(21-9-5-3-6-10-21)26(35)33-15-13-28(14-16-33,23-11-7-4-8-12-23)31-27-29-18-22(19-30-27)25(34)32-36/h3-12,18-20,24,36H,13-17H2,1-2H3,(H,32,34)(H,29,30,31)/t24-/m1/s1
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n/an/a 12n/an/an/an/a7.425



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...


US Patent US9278963 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M0K
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM213181
PNG
(US9278963, 031)
Show SMILES ONC(=O)c1cnc(NC2(CCN(CC2)C(=O)Cc2cc3ccccc3[nH]2)c2ccccc2)nc1
Show InChI InChI=1S/C26H26N6O3/c33-23(15-21-14-18-6-4-5-9-22(18)29-21)32-12-10-26(11-13-32,20-7-2-1-3-8-20)30-25-27-16-19(17-28-25)24(34)31-35/h1-9,14,16-17,29,35H,10-13,15H2,(H,31,34)(H,27,28,30)
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n/an/a 5n/an/an/an/a7.425



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...


US Patent US9278963 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M0K
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM29589
PNG
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Show SMILES Cc1[nH]c2ccccc2c1CCNCc1ccc(\C=C\C(=O)NO)cc1
Show InChI InChI=1S/C21H23N3O2/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6-16(7-9-17)10-11-21(25)24-26/h2-11,22-23,26H,12-14H2,1H3,(H,24,25)/b11-10+
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n/an/a 2n/an/an/an/a7.425



Broad Institute of Harvard and MIT



Assay Description
Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...


ACS Chem Biol 11: 363-74 (2016)


Article DOI: 10.1021/acschembio.5b00640
BindingDB Entry DOI: 10.7270/Q2BZ64T2
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM19149
PNG
(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccccc1
Show InChI InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
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n/an/a 2n/an/an/an/a7.425



Broad Institute of Harvard and MIT



Assay Description
Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...


ACS Chem Biol 11: 363-74 (2016)


Article DOI: 10.1021/acschembio.5b00640
BindingDB Entry DOI: 10.7270/Q2BZ64T2
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM19422
PNG
(4-(acetylamino)-N-(2-amino-phenyl) benzamide | CI-...)
Show SMILES CC(=O)Nc1ccc(cc1)C(=O)Nc1ccccc1N
Show InChI InChI=1S/C15H15N3O2/c1-10(19)17-12-8-6-11(7-9-12)15(20)18-14-5-3-2-4-13(14)16/h2-9H,16H2,1H3,(H,17,19)(H,18,20)
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n/an/a>3.33E+4n/an/an/an/a7.425



Broad Institute of Harvard and MIT



Assay Description
Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...


ACS Chem Biol 11: 363-74 (2016)


Article DOI: 10.1021/acschembio.5b00640
BindingDB Entry DOI: 10.7270/Q2BZ64T2
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM178095
PNG
(BRD2492)
Show SMILES CC(=O)Nc1ccc(cc1)C(=O)Nc1cc(ccc1N)-c1ccncc1
Show InChI InChI=1S/C20H18N4O2/c1-13(25)23-17-5-2-15(3-6-17)20(26)24-19-12-16(4-7-18(19)21)14-8-10-22-11-9-14/h2-12H,21H2,1H3,(H,23,25)(H,24,26)
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n/an/a>3.33E+4n/an/an/an/a7.425



Broad Institute of Harvard and MIT



Assay Description
Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...


ACS Chem Biol 11: 363-74 (2016)


Article DOI: 10.1021/acschembio.5b00640
BindingDB Entry DOI: 10.7270/Q2BZ64T2
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM178100
PNG
(BRD3308)
Show SMILES CC(=O)Nc1ccc(cc1)C(=O)Nc1ccc(F)cc1N
Show InChI InChI=1S/C15H14FN3O2/c1-9(20)18-12-5-2-10(3-6-12)15(21)19-14-7-4-11(16)8-13(14)17/h2-8H,17H2,1H3,(H,18,20)(H,19,21)
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n/an/a>3.33E+4n/an/an/an/a7.425



Broad Institute of Harvard and MIT



Assay Description
Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...


ACS Chem Biol 11: 363-74 (2016)


Article DOI: 10.1021/acschembio.5b00640
BindingDB Entry DOI: 10.7270/Q2BZ64T2
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM213154
PNG
(US9278963, 001)
Show SMILES ONC(=O)c1cnc(NC2(CCN(CC2)C(=O)Nc2ccccc2)c2ccccc2)nc1
Show InChI InChI=1S/C23H24N6O3/c30-20(28-32)17-15-24-21(25-16-17)27-23(18-7-3-1-4-8-18)11-13-29(14-12-23)22(31)26-19-9-5-2-6-10-19/h1-10,15-16,32H,11-14H2,(H,26,31)(H,28,30)(H,24,25,27)
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n/an/a 1.90n/an/an/an/a7.425



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...


US Patent US9278963 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M0K
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM213155
PNG
(US9278963, 002)
Show SMILES ONC(=O)c1cnc(NC2(CCN(CC2)C(=O)OCc2ccccc2)c2ccccc2)nc1
Show InChI InChI=1S/C24H25N5O4/c30-21(28-32)19-15-25-22(26-16-19)27-24(20-9-5-2-6-10-20)11-13-29(14-12-24)23(31)33-17-18-7-3-1-4-8-18/h1-10,15-16,32H,11-14,17H2,(H,28,30)(H,25,26,27)
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n/an/a 2.60n/an/an/an/a7.425



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...


US Patent US9278963 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M0K
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM213156
PNG
(US9278963, 003)
Show SMILES CC(=O)N1CCC(CC1)(Nc1ncc(cn1)C(=O)NO)c1ccccc1
Show InChI InChI=1S/C18H21N5O3/c1-13(24)23-9-7-18(8-10-23,15-5-3-2-4-6-15)21-17-19-11-14(12-20-17)16(25)22-26/h2-6,11-12,26H,7-10H2,1H3,(H,22,25)(H,19,20,21)
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n/an/a 1.60n/an/an/an/a7.425



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...


US Patent US9278963 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M0K
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM213157
PNG
(US9278963, 004)
Show SMILES CCON1CCC(CC1)(Nc1ncc(cn1)C(=O)NO)c1ccccc1
Show InChI InChI=1S/C18H23N5O3/c1-2-26-23-10-8-18(9-11-23,15-6-4-3-5-7-15)21-17-19-12-14(13-20-17)16(24)22-25/h3-7,12-13,25H,2,8-11H2,1H3,(H,22,24)(H,19,20,21)
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n/an/a 2.90n/an/an/an/a7.425



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...


US Patent US9278963 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M0K
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM213158
PNG
(US9278963, 005)
Show SMILES CC(C)C1(CCN(CC1)C(C)=O)Nc1ncc(cn1)C(=O)NO
Show InChI InChI=1S/C15H23N5O3/c1-10(2)15(4-6-20(7-5-15)11(3)21)18-14-16-8-12(9-17-14)13(22)19-23/h8-10,23H,4-7H2,1-3H3,(H,19,22)(H,16,17,18)
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n/an/a 5.90n/an/an/an/a7.425



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...


US Patent US9278963 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M0K
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM213159
PNG
(US9278963, 006)
Show SMILES CCON1CCC(CC1)(Nc1ncc(cn1)C(=O)NO)C(C)C
Show InChI InChI=1S/C15H25N5O3/c1-4-23-20-7-5-15(6-8-20,11(2)3)18-14-16-9-12(10-17-14)13(21)19-22/h9-11,22H,4-8H2,1-3H3,(H,19,21)(H,16,17,18)
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n/an/a 4n/an/an/an/a7.425



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...


US Patent US9278963 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M0K
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM213182
PNG
(US9278963, 007)
Show SMILES CC(C)C1(CCN(CC1)C(=O)OCc1ccccc1)Nc1ncc(cn1)C(=O)NO
Show InChI InChI=1S/C21H27N5O4/c1-15(2)21(24-19-22-12-17(13-23-19)18(27)25-29)8-10-26(11-9-21)20(28)30-14-16-6-4-3-5-7-16/h3-7,12-13,15,29H,8-11,14H2,1-2H3,(H,25,27)(H,22,23,24)
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n/an/a 5.10n/an/an/an/a7.425



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...


US Patent US9278963 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M0K
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM213161
PNG
(US9278963, 008)
Show SMILES COc1ccc(NC(=O)N2CCC(CC2)(Nc2ncc(cn2)C(=O)NO)c2ccccc2)cc1
Show InChI InChI=1S/C24H26N6O4/c1-34-20-9-7-19(8-10-20)27-23(32)30-13-11-24(12-14-30,18-5-3-2-4-6-18)28-22-25-15-17(16-26-22)21(31)29-33/h2-10,15-16,33H,11-14H2,1H3,(H,27,32)(H,29,31)(H,25,26,28)
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n/an/a 1.5n/an/an/an/a7.425



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...


US Patent US9278963 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M0K
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM213162
PNG
(US9278963, 009)
Show SMILES ONC(=O)c1cnc(NC2(CCN(CC2)c2ccccc2)c2ccccc2)nc1
Show InChI InChI=1S/C22H23N5O2/c28-20(26-29)17-15-23-21(24-16-17)25-22(18-7-3-1-4-8-18)11-13-27(14-12-22)19-9-5-2-6-10-19/h1-10,15-16,29H,11-14H2,(H,26,28)(H,23,24,25)
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n/an/a 2.10n/an/an/an/a7.425



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...


US Patent US9278963 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M0K
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM213163
PNG
(US9278963, 010)
Show SMILES ONC(=O)c1cnc(NC2(CCN(CC2)C(=O)Nc2ccccc2F)c2ccccc2)nc1
Show InChI InChI=1S/C23H23FN6O3/c24-18-8-4-5-9-19(18)27-22(32)30-12-10-23(11-13-30,17-6-2-1-3-7-17)28-21-25-14-16(15-26-21)20(31)29-33/h1-9,14-15,33H,10-13H2,(H,27,32)(H,29,31)(H,25,26,28)
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n/an/a 1.70n/an/an/an/a7.425



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...


US Patent US9278963 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M0K
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM213164
PNG
(US9278963, 011)
Show SMILES ONC(=O)c1cnc(NC2(CCN(CC2)C(=O)Nc2ccc(Cl)c(Cl)c2)c2ccccc2)nc1
Show InChI InChI=1S/C23H22Cl2N6O3/c24-18-7-6-17(12-19(18)25)28-22(33)31-10-8-23(9-11-31,16-4-2-1-3-5-16)29-21-26-13-15(14-27-21)20(32)30-34/h1-7,12-14,34H,8-11H2,(H,28,33)(H,30,32)(H,26,27,29)
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n/an/a 14n/an/an/an/a7.425



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...


US Patent US9278963 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M0K
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM213165
PNG
(US9278963, 012)
Show SMILES CN(C(=O)N1CCC(CC1)(Nc1ncc(cn1)C(=O)NO)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H26N6O3/c1-29(20-10-6-3-7-11-20)23(32)30-14-12-24(13-15-30,19-8-4-2-5-9-19)27-22-25-16-18(17-26-22)21(31)28-33/h2-11,16-17,33H,12-15H2,1H3,(H,28,31)(H,25,26,27)
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n/an/a 2.20n/an/an/an/a7.425



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...


US Patent US9278963 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M0K
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM213166
PNG
(US9278963, 013)
Show SMILES ONC(=O)c1cnc(NC2(CCN(CC2)C(=O)Nc2cccc(F)c2)c2ccccc2)nc1
Show InChI InChI=1S/C23H23FN6O3/c24-18-7-4-8-19(13-18)27-22(32)30-11-9-23(10-12-30,17-5-2-1-3-6-17)28-21-25-14-16(15-26-21)20(31)29-33/h1-8,13-15,33H,9-12H2,(H,27,32)(H,29,31)(H,25,26,28)
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n/an/a 2.5n/an/an/an/a7.425



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...


US Patent US9278963 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M0K
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM213167
PNG
(US9278963, 014)
Show SMILES ONC(=O)c1cnc(NC2(CCN(CC2)C(=O)Nc2ccc(F)cc2)c2ccccc2)nc1
Show InChI InChI=1S/C23H23FN6O3/c24-18-6-8-19(9-7-18)27-22(32)30-12-10-23(11-13-30,17-4-2-1-3-5-17)28-21-25-14-16(15-26-21)20(31)29-33/h1-9,14-15,33H,10-13H2,(H,27,32)(H,29,31)(H,25,26,28)
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n/an/a 2n/an/an/an/a7.425



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...


US Patent US9278963 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M0K
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM213168
PNG
(US9278963, 015)
Show SMILES Cc1ccc(NC(=O)N2CCC(CC2)(Nc2ncc(cn2)C(=O)NO)c2ccccc2)cc1
Show InChI InChI=1S/C24H26N6O3/c1-17-7-9-20(10-8-17)27-23(32)30-13-11-24(12-14-30,19-5-3-2-4-6-19)28-22-25-15-18(16-26-22)21(31)29-33/h2-10,15-16,33H,11-14H2,1H3,(H,27,32)(H,29,31)(H,25,26,28)
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n/an/a 2n/an/an/an/a7.425



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...


US Patent US9278963 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M0K
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM213169
PNG
(US9278963, 016)
Show SMILES CNC(=O)N1CCC(CC1)(Nc1ncc(cn1)C(=O)NO)c1ccccc1
Show InChI InChI=1S/C18H22N6O3/c1-19-17(26)24-9-7-18(8-10-24,14-5-3-2-4-6-14)22-16-20-11-13(12-21-16)15(25)23-27/h2-6,11-12,27H,7-10H2,1H3,(H,19,26)(H,23,25)(H,20,21,22)
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n/an/a 1.70n/an/an/an/a7.425



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...


US Patent US9278963 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M0K
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM213170
PNG
(US9278963, 017)
Show SMILES ONC(=O)c1cnc(NC2(CCN(CC2)C(=S)Nc2ccccc2)c2ccccc2)nc1
Show InChI InChI=1S/C23H24N6O2S/c30-20(28-31)17-15-24-21(25-16-17)27-23(18-7-3-1-4-8-18)11-13-29(14-12-23)22(32)26-19-9-5-2-6-10-19/h1-10,15-16,31H,11-14H2,(H,26,32)(H,28,30)(H,24,25,27)
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n/an/a 2.40n/an/an/an/a7.425



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentrat...


US Patent US9278963 (2016)


BindingDB Entry DOI: 10.7270/Q2GT5M0K
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM139359
PNG
(US8614223, 145)
Show SMILES ONC(=O)c1cnc(NC2(CC2)c2cc(cc(c2)C(F)(F)F)C(F)(F)F)nc1
Show InChI InChI=1S/C16H12F6N4O2/c17-15(18,19)10-3-9(4-11(5-10)16(20,21)22)14(1-2-14)25-13-23-6-8(7-24-13)12(27)26-28/h3-7,28H,1-2H2,(H,26,27)(H,23,24,25)
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n/an/a 6n/an/an/an/a7.425



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8614223 (2013)


BindingDB Entry DOI: 10.7270/Q2B27T00
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM139360
PNG
(US8614223, 146)
Show SMILES ONC(=O)c1cnc(NC2(CC2)c2cc(Cl)cc(Cl)c2)nc1
Show InChI InChI=1S/C14H12Cl2N4O2/c15-10-3-9(4-11(16)5-10)14(1-2-14)19-13-17-6-8(7-18-13)12(21)20-22/h3-7,22H,1-2H2,(H,20,21)(H,17,18,19)
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n/an/a 3n/an/an/an/a7.425



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8614223 (2013)


BindingDB Entry DOI: 10.7270/Q2B27T00
More data for this
Ligand-Target Pair
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