BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 3167 hits Enz. Inhib. hit(s) with Target = 'Corticotropin releasing factor receptor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20933
PNG
(3,6-dimethyl-4-(pentan-3-yloxy)-2-(2,4,6-trimethyl...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C
Show InChI InChI=1S/C21H29NO2/c1-8-18(9-2)23-19-12-16(6)22-21(17(19)7)24-20-14(4)10-13(3)11-15(20)5/h10-12,18H,8-9H2,1-7H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 6.80n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20992
PNG
(1-(4-{4-[butyl(ethyl)amino]-2-methyl-5,6,7,8-tetra...)
Show SMILES CCCCN(CC)c1nc(C)nc2N(CCNc12)c1ccc(cc1C)C(C)=O
Show InChI InChI=1S/C22H31N5O/c1-6-8-12-26(7-2)21-20-22(25-17(5)24-21)27(13-11-23-20)19-10-9-18(16(4)28)14-15(19)3/h9-10,14,23H,6-8,11-13H2,1-5H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 172n/an/an/an/a7.023



Bristol-Myers Squibb Company



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 50: 2269-72 (2007)


Article DOI: 10.1021/jm0611410
BindingDB Entry DOI: 10.7270/Q25Q4TCS
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20935
PNG
(2-Aryloxy-4-alkoxy-pyridine, 16 | 3-ethyl-6-methyl...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1CC
Show InChI InChI=1S/C22H31NO2/c1-8-18(9-2)24-20-13-17(7)23-22(19(20)10-3)25-21-15(5)11-14(4)12-16(21)6/h11-13,18H,8-10H2,1-7H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 9.10n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20936
PNG
(2-Aryloxy-4-alkoxy-pyridine, 17 | 2-methyl-4-(pent...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1
Show InChI InChI=1S/C20H27NO2/c1-7-17(8-2)22-18-11-16(6)21-19(12-18)23-20-14(4)9-13(3)10-15(20)5/h9-12,17H,7-8H2,1-6H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 150n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20937
PNG
(2-Aryloxy-4-alkoxy-pyridine, 18 | methyl 6-methyl-...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C(=O)OC
Show InChI InChI=1S/C22H29NO4/c1-8-17(9-2)26-18-12-16(6)23-21(19(18)22(24)25-7)27-20-14(4)10-13(3)11-15(20)5/h10-12,17H,8-9H2,1-7H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 470n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20938
PNG
(2-Aryloxy-4-alkoxy-pyridine, 19 | 6-methyl-3-nitro...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1[N+]([O-])=O
Show InChI InChI=1S/C20H26N2O4/c1-7-16(8-2)25-17-11-15(6)21-20(18(17)22(23)24)26-19-13(4)9-12(3)10-14(19)5/h9-11,16H,7-8H2,1-6H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 15n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20939
PNG
(2-Aryloxy-4-alkoxy-pyridine, 20 | 6-methyl-4-(pent...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1N
Show InChI InChI=1S/C20H28N2O2/c1-7-16(8-2)23-17-11-15(6)22-20(18(17)21)24-19-13(4)9-12(3)10-14(19)5/h9-11,16H,7-8,21H2,1-6H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 12n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20940
PNG
(2-Aryloxy-4-alkoxy-pyridine, 21 | N,N,6-trimethyl-...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1N(C)C
Show InChI InChI=1S/C22H32N2O2/c1-9-18(10-2)25-19-13-17(6)23-22(20(19)24(7)8)26-21-15(4)11-14(3)12-16(21)5/h11-13,18H,9-10H2,1-8H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 25n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20941
PNG
(2-Aryloxy-4-alkoxy-pyridine, 22 | 3-bromo-6-methyl...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1Br
Show InChI InChI=1S/C20H26BrNO2/c1-7-16(8-2)23-17-11-15(6)22-20(18(17)21)24-19-13(4)9-12(3)10-14(19)5/h9-11,16H,7-8H2,1-6H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 9.80n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20942
PNG
(2-Aryloxy-4-alkoxy-pyridine, 23 | 6-methyl-4-(pent...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C(O)=O
Show InChI InChI=1S/C21H27NO4/c1-7-16(8-2)25-17-11-15(6)22-20(18(17)21(23)24)26-19-13(4)9-12(3)10-14(19)5/h9-11,16H,7-8H2,1-6H3,(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20943
PNG
(2,3,5-trimethyl-4-(pentan-3-yloxy)-6-(2,4,6-trimet...)
Show SMILES CCC(CC)Oc1c(C)c(C)nc(Oc2c(C)cc(C)cc2C)c1C
Show InChI InChI=1S/C22H31NO2/c1-9-19(10-2)24-21-16(6)18(8)23-22(17(21)7)25-20-14(4)11-13(3)12-15(20)5/h11-12,19H,9-10H2,1-8H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 180n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20944
PNG
(2-Aryloxy-4-alkoxy-pyridine, 25 | 3-ethyl-2,5-dime...)
Show SMILES CCC(CC)Oc1c(C)c(Oc2c(C)cc(C)cc2C)nc(C)c1CC
Show InChI InChI=1S/C23H33NO2/c1-9-19(10-2)25-22-17(7)23(24-18(8)20(22)11-3)26-21-15(5)12-14(4)13-16(21)6/h12-13,19H,9-11H2,1-8H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20945
PNG
(2-(2,6-dimethylphenoxy)-3,6-dimethyl-4-(pentan-3-y...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cccc2C)c1C
Show InChI InChI=1S/C20H27NO2/c1-7-17(8-2)22-18-12-15(5)21-20(16(18)6)23-19-13(3)10-9-11-14(19)4/h9-12,17H,7-8H2,1-6H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 110n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20946
PNG
(2-(4-ethyl-2,6-dimethylphenoxy)-3,6-dimethyl-4-(pe...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(CC)cc2C)c1C
Show InChI InChI=1S/C22H31NO2/c1-8-18-11-14(4)21(15(5)12-18)25-22-17(7)20(13-16(6)23-22)24-19(9-2)10-3/h11-13,19H,8-10H2,1-7H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 11n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20947
PNG
(2-(2,6-dimethyl-4-propylphenoxy)-3,6-dimethyl-4-(p...)
Show SMILES CCCc1cc(C)c(Oc2nc(C)cc(OC(CC)CC)c2C)c(C)c1
Show InChI InChI=1S/C23H33NO2/c1-8-11-19-12-15(4)22(16(5)13-19)26-23-18(7)21(14-17(6)24-23)25-20(9-2)10-3/h12-14,20H,8-11H2,1-7H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 9.80n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20948
PNG
(2-(4-fluoro-2,6-dimethylphenoxy)-3,6-dimethyl-4-(p...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(F)cc2C)c1C
Show InChI InChI=1S/C20H26FNO2/c1-7-17(8-2)23-18-11-14(5)22-20(15(18)6)24-19-12(3)9-16(21)10-13(19)4/h9-11,17H,7-8H2,1-6H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 32n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20949
PNG
(2-(4-chloro-2,6-dimethylphenoxy)-3,6-dimethyl-4-(p...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(Cl)cc2C)c1C
Show InChI InChI=1S/C20H26ClNO2/c1-7-17(8-2)23-18-11-14(5)22-20(15(18)6)24-19-12(3)9-16(21)10-13(19)4/h9-11,17H,7-8H2,1-6H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 5.5n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20950
PNG
(2-(4-bromo-2,6-dimethylphenoxy)-3,6-dimethyl-4-(pe...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(Br)cc2C)c1C
Show InChI InChI=1S/C20H26BrNO2/c1-7-17(8-2)23-18-11-14(5)22-20(15(18)6)24-19-12(3)9-16(21)10-13(19)4/h9-11,17H,7-8H2,1-6H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.60n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20951
PNG
(2-(4-iodo-2,6-dimethylphenoxy)-3,6-dimethyl-4-(pen...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(I)cc2C)c1C
Show InChI InChI=1S/C20H26INO2/c1-7-17(8-2)23-18-11-14(5)22-20(15(18)6)24-19-12(3)9-16(21)10-13(19)4/h9-11,17H,7-8H2,1-6H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 12n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20952
PNG
(2-Aryloxy-4-alkoxy-pyridine, 33 | 4-{[3,6-dimethyl...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(cc2C)C(N)=O)c1C
Show InChI InChI=1S/C21H28N2O3/c1-7-17(8-2)25-18-11-14(5)23-21(15(18)6)26-19-12(3)9-16(20(22)24)10-13(19)4/h9-11,17H,7-8H2,1-6H3,(H2,22,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 18n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20953
PNG
(2-Aryloxy-4-alkoxy-pyridine, 34 | 4-{[3,6-dimethyl...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(O)cc2C)c1C
Show InChI InChI=1S/C20H27NO3/c1-7-17(8-2)23-18-11-14(5)21-20(15(18)6)24-19-12(3)9-16(22)10-13(19)4/h9-11,17,22H,7-8H2,1-6H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.40E+3n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20954
PNG
(2-(4-methoxy-2,6-dimethylphenoxy)-3,6-dimethyl-4-(...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(OC)cc2C)c1C
Show InChI InChI=1S/C21H29NO3/c1-8-17(9-2)24-19-12-15(5)22-21(16(19)6)25-20-13(3)10-18(23-7)11-14(20)4/h10-12,17H,8-9H2,1-7H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20955
PNG
(2-(4-ethoxy-2,6-dimethylphenoxy)-3,6-dimethyl-4-(p...)
Show SMILES CCOc1cc(C)c(Oc2nc(C)cc(OC(CC)CC)c2C)c(C)c1
Show InChI InChI=1S/C22H31NO3/c1-8-18(9-2)25-20-13-16(6)23-22(17(20)7)26-21-14(4)11-19(24-10-3)12-15(21)5/h11-13,18H,8-10H2,1-7H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 20n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20956
PNG
(2-Aryloxy-4-alkoxy-pyridine, 37 | 2-[2,6-dimethyl-...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(OC(C)C)cc2C)c1C
Show InChI InChI=1S/C23H33NO3/c1-9-19(10-2)26-21-13-17(7)24-23(18(21)8)27-22-15(5)11-20(12-16(22)6)25-14(3)4/h11-14,19H,9-10H2,1-8H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 110n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20957
PNG
(2-Aryloxy-4-alkoxy-pyridine, 38 | 4-{[3,6-dimethyl...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C=O)cc2C)c1C
Show InChI InChI=1S/C21H27NO3/c1-7-18(8-2)24-19-11-15(5)22-21(16(19)6)25-20-13(3)9-17(12-23)10-14(20)4/h9-12,18H,7-8H2,1-6H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 40n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20958
PNG
((4-{[3,6-dimethyl-4-(pentan-3-yloxy)pyridin-2-yl]o...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(CO)cc2C)c1C
Show InChI InChI=1S/C21H29NO3/c1-7-18(8-2)24-19-11-15(5)22-21(16(19)6)25-20-13(3)9-17(12-23)10-14(20)4/h9-11,18,23H,7-8,12H2,1-6H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 61n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20959
PNG
(2-Aryloxy-4-alkoxy-pyridine, 40 | 2-[4-(methoxymet...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(COC)cc2C)c1C
Show InChI InChI=1S/C22H31NO3/c1-8-19(9-2)25-20-12-16(5)23-22(17(20)6)26-21-14(3)10-18(13-24-7)11-15(21)4/h10-12,19H,8-9,13H2,1-7H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.20n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20960
PNG
(2-(4-{[3,6-dimethyl-4-(pentan-3-yloxy)pyridin-2-yl...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(cc2C)C(C)(C)O)c1C
Show InChI InChI=1S/C23H33NO3/c1-9-19(10-2)26-20-13-16(5)24-22(17(20)6)27-21-14(3)11-18(12-15(21)4)23(7,8)25/h11-13,19,25H,9-10H2,1-8H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 40n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20961
PNG
(2-Aryloxy-4-alkoxy-pyridine, 42 | 4-(butan-2-yloxy...)
Show SMILES CCC(C)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C
Show InChI InChI=1S/C20H27NO2/c1-8-16(6)22-18-11-15(5)21-20(17(18)7)23-19-13(3)9-12(2)10-14(19)4/h9-11,16H,8H2,1-7H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 28n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20962
PNG
(2-Aryloxy-4-alkoxy-pyridine, 43 | 4-[(1-methoxybut...)
Show SMILES CCC(COC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C
Show InChI InChI=1S/C21H29NO3/c1-8-18(12-23-7)24-19-11-16(5)22-21(17(19)6)25-20-14(3)9-13(2)10-15(20)4/h9-11,18H,8,12H2,1-7H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 11n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20933
PNG
(3,6-dimethyl-4-(pentan-3-yloxy)-2-(2,4,6-trimethyl...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C
Show InChI InChI=1S/C21H29NO2/c1-8-18(9-2)23-19-12-16(6)22-21(17(19)7)24-20-14(4)10-13(3)11-15(20)5/h10-12,18H,8-9H2,1-7H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 6.80n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1385-92 (2008)


Article DOI: 10.1021/jm070579c
BindingDB Entry DOI: 10.7270/Q29C6VQ7
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20966
PNG
(2-Aryloxy-4-alkylaminopyridine, 3a | 3,6-dimethyl-...)
Show SMILES CCC(CC)Nc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C
Show InChI InChI=1S/C21H30N2O/c1-8-18(9-2)23-19-12-16(6)22-21(17(19)7)24-20-14(4)10-13(3)11-15(20)5/h10-12,18H,8-9H2,1-7H3,(H,22,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 5.10n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1385-92 (2008)


Article DOI: 10.1021/jm070579c
BindingDB Entry DOI: 10.7270/Q29C6VQ7
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20967
PNG
(2-(4-chloro-2,6-dimethylphenoxy)-3,6-dimethyl-N-(p...)
Show SMILES CCC(CC)Nc1cc(C)nc(Oc2c(C)cc(Cl)cc2C)c1C
Show InChI InChI=1S/C20H27ClN2O/c1-7-17(8-2)23-18-11-14(5)22-20(15(18)6)24-19-12(3)9-16(21)10-13(19)4/h9-11,17H,7-8H2,1-6H3,(H,22,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.20n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1385-92 (2008)


Article DOI: 10.1021/jm070579c
BindingDB Entry DOI: 10.7270/Q29C6VQ7
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20968
PNG
(2-(4-bromo-2,6-dimethylphenoxy)-3,6-dimethyl-N-(pe...)
Show SMILES CCC(CC)Nc1cc(C)nc(Oc2c(C)cc(Br)cc2C)c1C
Show InChI InChI=1S/C20H27BrN2O/c1-7-17(8-2)23-18-11-14(5)22-20(15(18)6)24-19-12(3)9-16(21)10-13(19)4/h9-11,17H,7-8H2,1-6H3,(H,22,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.60n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1385-92 (2008)


Article DOI: 10.1021/jm070579c
BindingDB Entry DOI: 10.7270/Q29C6VQ7
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20969
PNG
(2-Aryloxy-4-alkylaminopyridine, 5a | methyl 2-(4-c...)
Show SMILES CC[C@@H](CO)Nc1cc(C)nc(Oc2c(C)cc(Cl)cc2C)c1C(=O)OC
Show InChI InChI=1S/C20H25ClN2O4/c1-6-15(10-24)23-16-9-13(4)22-19(17(16)20(25)26-5)27-18-11(2)7-14(21)8-12(18)3/h7-9,15,24H,6,10H2,1-5H3,(H,22,23)/t15-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 6.40n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1385-92 (2008)


Article DOI: 10.1021/jm070579c
BindingDB Entry DOI: 10.7270/Q29C6VQ7
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20970
PNG
(2-(4-chloro-2,6-dimethylphenoxy)-4-{[(2S)-1-hydrox...)
Show SMILES CC[C@@H](CO)Nc1cc(C)nc(Oc2c(C)cc(Cl)cc2C)c1C(=O)NC
Show InChI InChI=1S/C20H26ClN3O3/c1-6-15(10-25)24-16-9-13(4)23-20(17(16)19(26)22-5)27-18-11(2)7-14(21)8-12(18)3/h7-9,15,25H,6,10H2,1-5H3,(H,22,26)(H,23,24)/t15-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 31n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1385-92 (2008)


Article DOI: 10.1021/jm070579c
BindingDB Entry DOI: 10.7270/Q29C6VQ7
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20971
PNG
(2-Arylamino-4-alkyloxypyridine, 13 | 3,6-dimethyl-...)
Show SMILES CCC(CC)Oc1cc(C)nc(Nc2c(C)cc(C)cc2C)c1C
Show InChI InChI=1S/C21H30N2O/c1-8-18(9-2)24-19-12-16(6)22-21(17(19)7)23-20-14(4)10-13(3)11-15(20)5/h10-12,18H,8-9H2,1-7H3,(H,22,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.70n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1385-92 (2008)


Article DOI: 10.1021/jm070579c
BindingDB Entry DOI: 10.7270/Q29C6VQ7
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20972
PNG
(2,4-diaminopyridine, 16 | 3,6-dimethyl-4-N-(pentan...)
Show SMILES CCC(CC)Nc1cc(C)nc(Nc2c(C)cc(C)cc2C)c1C
Show InChI InChI=1S/C21H31N3/c1-8-18(9-2)23-19-12-16(6)22-21(17(19)7)24-20-14(4)10-13(3)11-15(20)5/h10-12,18H,8-9H2,1-7H3,(H2,22,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 750n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1385-92 (2008)


Article DOI: 10.1021/jm070579c
BindingDB Entry DOI: 10.7270/Q29C6VQ7
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20973
PNG
(8-[butyl(ethyl)amino]-4-(4-methoxy-2-methylphenyl)...)
Show SMILES CCCCN(CC)c1cc(C)nc2N(CC(=O)Nc12)c1ccc(OC)cc1C
Show InChI InChI=1S/C22H30N4O2/c1-6-8-11-25(7-2)19-13-16(4)23-22-21(19)24-20(27)14-26(22)18-10-9-17(28-5)12-15(18)3/h9-10,12-13H,6-8,11,14H2,1-5H3,(H,24,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.920n/an/an/an/a7.023



Bristol-Myers Squibb Company



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 50: 2269-72 (2007)


Article DOI: 10.1021/jm0611410
BindingDB Entry DOI: 10.7270/Q25Q4TCS
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20974
PNG
(N-butyl-N-ethyl-4-(4-methoxy-2-methylphenyl)-6-met...)
Show SMILES CCCCN(CC)c1cc(C)nc2N(CCNc12)c1ccc(OC)cc1C
Show InChI InChI=1S/C22H32N4O/c1-6-8-12-25(7-2)20-15-17(4)24-22-21(20)23-11-13-26(22)19-10-9-18(27-5)14-16(19)3/h9-10,14-15,23H,6-8,11-13H2,1-5H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.20n/an/an/an/a7.023



Bristol-Myers Squibb Company



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 50: 2269-72 (2007)


Article DOI: 10.1021/jm0611410
BindingDB Entry DOI: 10.7270/Q25Q4TCS
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20975
PNG
(4-[butyl(ethyl)amino]-8-(4-methoxy-2-methylphenyl)...)
Show SMILES CCCCN(CC)c1nc(C)nc2N(CC(=O)Nc12)c1ccc(OC)cc1C
Show InChI InChI=1S/C21H29N5O2/c1-6-8-11-25(7-2)20-19-21(23-15(4)22-20)26(13-18(27)24-19)17-10-9-16(28-5)12-14(17)3/h9-10,12H,6-8,11,13H2,1-5H3,(H,24,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 95n/an/an/an/a7.023



Bristol-Myers Squibb Company



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 50: 2269-72 (2007)


Article DOI: 10.1021/jm0611410
BindingDB Entry DOI: 10.7270/Q25Q4TCS
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20976
PNG
(N-butyl-N-ethyl-8-(4-methoxy-2-methylphenyl)-2-met...)
Show SMILES CCCCN(CC)c1nc(C)nc2N(CCNc12)c1ccc(OC)cc1C
Show InChI InChI=1S/C21H31N5O/c1-6-8-12-25(7-2)20-19-21(24-16(4)23-20)26(13-11-22-19)18-10-9-17(27-5)14-15(18)3/h9-10,14,22H,6-8,11-13H2,1-5H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 11.7n/an/an/an/a7.023



Bristol-Myers Squibb Company



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 50: 2269-72 (2007)


Article DOI: 10.1021/jm0611410
BindingDB Entry DOI: 10.7270/Q25Q4TCS
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20977
PNG
(8-[butyl(ethyl)amino]-4-(2,6-dimethoxypyridin-3-yl...)
Show SMILES CCCCN(CC)c1cc(C)nc2N(CC(=O)Nc12)c1ccc(OC)nc1OC
Show InChI InChI=1S/C21H29N5O3/c1-6-8-11-25(7-2)16-12-14(3)22-20-19(16)23-17(27)13-26(20)15-9-10-18(28-4)24-21(15)29-5/h9-10,12H,6-8,11,13H2,1-5H3,(H,23,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.820n/an/an/an/a7.023



Bristol-Myers Squibb Company



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 50: 2269-72 (2007)


Article DOI: 10.1021/jm0611410
BindingDB Entry DOI: 10.7270/Q25Q4TCS
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20978
PNG
(N-butyl-4-(2,6-dimethoxypyridin-3-yl)-N-ethyl-6-me...)
Show SMILES CCCCN(CC)c1cc(C)nc2N(CCNc12)c1ccc(OC)nc1OC
Show InChI InChI=1S/C21H31N5O2/c1-6-8-12-25(7-2)17-14-15(3)23-20-19(17)22-11-13-26(20)16-9-10-18(27-4)24-21(16)28-5/h9-10,14,22H,6-8,11-13H2,1-5H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.20n/an/an/an/a7.023



Bristol-Myers Squibb Company



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 50: 2269-72 (2007)


Article DOI: 10.1021/jm0611410
BindingDB Entry DOI: 10.7270/Q25Q4TCS
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20979
PNG
(4-[butyl(ethyl)amino]-8-(2,6-dimethoxypyridin-3-yl...)
Show SMILES CCCCN(CC)c1nc(C)nc2N(CC(=O)Nc12)c1ccc(OC)nc1OC
Show InChI InChI=1S/C20H28N6O3/c1-6-8-11-25(7-2)18-17-19(22-13(3)21-18)26(12-15(27)23-17)14-9-10-16(28-4)24-20(14)29-5/h9-10H,6-8,11-12H2,1-5H3,(H,23,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 60n/an/an/an/a7.023



Bristol-Myers Squibb Company



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 50: 2269-72 (2007)


Article DOI: 10.1021/jm0611410
BindingDB Entry DOI: 10.7270/Q25Q4TCS
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20980
PNG
(N-butyl-8-(2,6-dimethoxypyridin-3-yl)-N-ethyl-2-me...)
Show SMILES CCCCN(CC)c1nc(C)nc2N(CCNc12)c1ccc(OC)nc1OC
Show InChI InChI=1S/C20H30N6O2/c1-6-8-12-25(7-2)18-17-19(23-14(3)22-18)26(13-11-21-17)15-9-10-16(27-4)24-20(15)28-5/h9-10,21H,6-8,11-13H2,1-5H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 9.90n/an/an/an/a7.023



Bristol-Myers Squibb Company



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 50: 2269-72 (2007)


Article DOI: 10.1021/jm0611410
BindingDB Entry DOI: 10.7270/Q25Q4TCS
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20981
PNG
(4-(4,5-dimethoxy-2-methylphenyl)-8-[(2-methoxyethy...)
Show SMILES CCCN(CCOC)c1cc(C)nc2N(CC(=O)Nc12)c1cc(OC)c(OC)cc1C
Show InChI InChI=1S/C23H32N4O4/c1-7-8-26(9-10-29-4)18-12-16(3)24-23-22(18)25-21(28)14-27(23)17-13-20(31-6)19(30-5)11-15(17)2/h11-13H,7-10,14H2,1-6H3,(H,25,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 43n/an/an/an/a7.023



Bristol-Myers Squibb Company



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 50: 2269-72 (2007)


Article DOI: 10.1021/jm0611410
BindingDB Entry DOI: 10.7270/Q25Q4TCS
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20982
PNG
(4-(4,5-dimethoxy-2-methylphenyl)-N-(2-methoxyethyl...)
Show SMILES CCCN(CCOC)c1cc(C)nc2N(CCNc12)c1cc(OC)c(OC)cc1C
Show InChI InChI=1S/C23H34N4O3/c1-7-9-26(11-12-28-4)19-14-17(3)25-23-22(19)24-8-10-27(23)18-15-21(30-6)20(29-5)13-16(18)2/h13-15,24H,7-12H2,1-6H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 87n/an/an/an/a7.023



Bristol-Myers Squibb Company



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 50: 2269-72 (2007)


Article DOI: 10.1021/jm0611410
BindingDB Entry DOI: 10.7270/Q25Q4TCS
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20983
PNG
(8-(4,5-dimethoxy-2-methylphenyl)-4-[(2-methoxyethy...)
Show SMILES CCCN(CCOC)c1nc(C)nc2N(CC(=O)Nc12)c1cc(OC)c(OC)cc1C
Show InChI InChI=1S/C22H31N5O4/c1-7-8-26(9-10-29-4)21-20-22(24-15(3)23-21)27(13-19(28)25-20)16-12-18(31-6)17(30-5)11-14(16)2/h11-12H,7-10,13H2,1-6H3,(H,25,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.11E+3n/an/an/an/a7.023



Bristol-Myers Squibb Company



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 50: 2269-72 (2007)


Article DOI: 10.1021/jm0611410
BindingDB Entry DOI: 10.7270/Q25Q4TCS
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20984
PNG
(8-(4,5-dimethoxy-2-methylphenyl)-N-(2-methoxyethyl...)
Show SMILES CCCN(CCOC)c1nc(C)nc2N(CCNc12)c1cc(OC)c(OC)cc1C
Show InChI InChI=1S/C22H33N5O3/c1-7-9-26(11-12-28-4)21-20-22(25-16(3)24-21)27(10-8-23-20)17-14-19(30-6)18(29-5)13-15(17)2/h13-14,23H,7-12H2,1-6H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 210n/an/an/an/a7.023



Bristol-Myers Squibb Company



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 50: 2269-72 (2007)


Article DOI: 10.1021/jm0611410
BindingDB Entry DOI: 10.7270/Q25Q4TCS
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 3167 total )  |  Next  |  Last  >>
Jump to: