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Compile Data Set for Download or QSAR

Found 3588 hits Enz. Inhib. hit(s) with Target = 'Cyclin-dependent kinase 1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7457
PNG
(2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4H-chromen-4...)
Show SMILES Oc1ccc2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O
Show InChI InChI=1S/C15H10O6/c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7/h1-6,16-18,20H
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PubMed
n/an/a 790n/an/an/an/a7.030



Lawrence Berkeley National Laboratory



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 48: 737-43 (2005)


Article DOI: 10.1021/jm049353p
BindingDB Entry DOI: 10.7270/Q2M61HG4
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7458
PNG
(5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one...)
Show SMILES Oc1ccc(cc1)-c1cc(=O)c2c(O)cc(O)cc2o1
Show InChI InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
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PubMed
n/an/a 4.00E+3n/an/an/an/a7.030



Lawrence Berkeley National Laboratory



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 48: 737-43 (2005)


Article DOI: 10.1021/jm049353p
BindingDB Entry DOI: 10.7270/Q2M61HG4
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7459
PNG
(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Show SMILES Oc1cc(O)c2c(c1)oc(cc2=O)-c1ccc(O)c(O)c1
Show InChI InChI=1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H
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PubMed
n/an/a 6.20E+3n/an/an/an/a7.030



Lawrence Berkeley National Laboratory



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 48: 737-43 (2005)


Article DOI: 10.1021/jm049353p
BindingDB Entry DOI: 10.7270/Q2M61HG4
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM5655
PNG
(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Show SMILES CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl
Show InChI InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1
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n/an/a 210n/an/an/an/a7.030



Lawrence Berkeley National Laboratory



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 48: 737-43 (2005)


Article DOI: 10.1021/jm049353p
BindingDB Entry DOI: 10.7270/Q2M61HG4
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7461
PNG
(5,7-dihydroxy-2-phenyl-4H-chromen-4-one | 5,7-dihy...)
Show SMILES Oc1cc(O)c2c(c1)oc(cc2=O)-c1ccccc1
Show InChI InChI=1S/C15H10O4/c16-10-6-11(17)15-12(18)8-13(19-14(15)7-10)9-4-2-1-3-5-9/h1-8,16-17H
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PubMed
n/an/a 7.10E+3n/an/an/an/a7.030



Lawrence Berkeley National Laboratory



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 48: 737-43 (2005)


Article DOI: 10.1021/jm049353p
BindingDB Entry DOI: 10.7270/Q2M61HG4
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7462
PNG
(3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-...)
Show SMILES Oc1ccc(cc1)-c1oc2cc(O)cc(O)c2c(=O)c1O
Show InChI InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H
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n/an/a 4.10E+4n/an/an/an/a7.030



Lawrence Berkeley National Laboratory



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 48: 737-43 (2005)


Article DOI: 10.1021/jm049353p
BindingDB Entry DOI: 10.7270/Q2M61HG4
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7460
PNG
(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)
Show SMILES Oc1cc(O)c2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O
Show InChI InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H
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n/an/a 7.50E+4n/an/an/an/a7.030



Lawrence Berkeley National Laboratory



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 48: 737-43 (2005)


Article DOI: 10.1021/jm049353p
BindingDB Entry DOI: 10.7270/Q2M61HG4
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7404
PNG
((2 Z)-6-Bromo-1-methylindirubin | 6-bromo-1-methyl...)
Show SMILES CN1C(=O)\C(=C2/Nc3ccccc3C2=O)c2ccc(Br)cc12
Show InChI InChI=1S/C17H11BrN2O2/c1-20-13-8-9(18)6-7-11(13)14(17(20)22)15-16(21)10-4-2-3-5-12(10)19-15/h2-8,19H,1H3/b15-14-
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n/an/a>1.00E+5n/an/an/an/a7.230



University of Athens



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 935-46 (2004)


Article DOI: 10.1021/jm031016d
BindingDB Entry DOI: 10.7270/Q20G3HB8
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7405
PNG
((2 Z,3 E)-6-Bromo-1-methylindirubin-3 -oxime | 6-b...)
Show SMILES CN1C(=O)C(c2ccc(Br)cc12)c1[nH]c2ccccc2c1N=O
Show InChI InChI=1S/C17H12BrN3O2/c1-21-13-8-9(18)6-7-11(13)14(17(21)22)16-15(20-23)10-4-2-3-5-12(10)19-16/h2-8,14,19H,1H3
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n/an/a 9.20E+4n/an/an/an/a7.230



University of Athens



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 935-46 (2004)


Article DOI: 10.1021/jm031016d
BindingDB Entry DOI: 10.7270/Q20G3HB8
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7406
PNG
((2 Z)-6-Chloroindirubin | 6-chloro-3-[(2Z)-3-oxo-2...)
Show SMILES Clc1ccc2\C(C(=O)Nc2c1)=C1\Nc2ccccc2C1=O
Show InChI InChI=1S/C16H9ClN2O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)14-15(20)10-3-1-2-4-11(10)18-14/h1-7,18H,(H,19,21)/b14-13-
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n/an/a>1.00E+5n/an/an/an/a7.230



University of Athens



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 935-46 (2004)


Article DOI: 10.1021/jm031016d
BindingDB Entry DOI: 10.7270/Q20G3HB8
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7407
PNG
((2 Z,3 E)-6-Chloroindirubin-3 -oxime | 6-chloro-3-...)
Show SMILES Clc1ccc2C(C(=O)Nc2c1)c1[nH]c2ccccc2c1N=O
Show InChI InChI=1S/C16H10ClN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,13,18H,(H,19,21)
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n/an/a 650n/an/an/an/a7.230



University of Athens



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 935-46 (2004)


Article DOI: 10.1021/jm031016d
BindingDB Entry DOI: 10.7270/Q20G3HB8
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7408
PNG
((2 Z,3 E)-6-Chloroindirubin-3 -acetoxime | 6-chlor...)
Show SMILES CC(=O)ON=C1C(Nc2ccccc12)=C1C(=O)Nc2cc(Cl)ccc12
Show InChI InChI=1S/C18H12ClN3O3/c1-9(23)25-22-16-12-4-2-3-5-13(12)20-17(16)15-11-7-6-10(19)8-14(11)21-18(15)24/h2-8,20H,1H3,(H,21,24)
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n/an/a 3.00E+4n/an/an/an/a7.230



University of Athens



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 935-46 (2004)


Article DOI: 10.1021/jm031016d
BindingDB Entry DOI: 10.7270/Q20G3HB8
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7409
PNG
((2 Z)-6-Iodoindirubin | 6-iodo-3-[(2Z)-3-oxo-2,3-d...)
Show SMILES Ic1ccc2\C(C(=O)Nc2c1)=C1\Nc2ccccc2C1=O
Show InChI InChI=1S/C16H9IN2O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)14-15(20)10-3-1-2-4-11(10)18-14/h1-7,18H,(H,19,21)/b14-13-
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n/an/a 1.60E+3n/an/an/an/a7.230



University of Athens



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 935-46 (2004)


Article DOI: 10.1021/jm031016d
BindingDB Entry DOI: 10.7270/Q20G3HB8
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7410
PNG
((2 Z,3 E)-6-Iodoindirubin-3 -oxime | 3-[(2Z,3E)-3-...)
Show SMILES Ic1ccc2C(C(=O)Nc2c1)c1[nH]c2ccccc2c1N=O
Show InChI InChI=1S/C16H10IN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,13,18H,(H,19,21)
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n/an/a 1.30E+3n/an/an/an/a7.230



University of Athens



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 935-46 (2004)


Article DOI: 10.1021/jm031016d
BindingDB Entry DOI: 10.7270/Q20G3HB8
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7280
PNG
(2-Bromo-9-Nitropaullone | 4-bromo-14-nitro-8,18-di...)
Show SMILES [O-][N+](=O)c1ccc2[nH]c-3c(CC(=O)Nc4ccc(Br)cc-34)c2c1
Show InChI InChI=1S/C16H10BrN3O3/c17-8-1-3-14-12(5-8)16-11(7-15(21)18-14)10-6-9(20(22)23)2-4-13(10)19-16/h1-6,19H,7H2,(H,18,21)
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n/an/a 53n/an/an/an/a7.230



CNRS



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...


Eur J Biochem 267: 5983-94 (2000)


Article DOI: 10.1210/endo.137.7.8770901
BindingDB Entry DOI: 10.7270/Q2CR5RJS
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7318
PNG
(14-bromo-4-iodo-8,18-diazatetracyclo[9.7.0.0^{2,7}...)
Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccc(I)cc-34)c2c1
Show InChI InChI=1S/C16H10BrIN2O/c17-8-1-3-13-10(5-8)11-7-15(21)19-14-4-2-9(18)6-12(14)16(11)20-13/h1-6,20H,7H2,(H,19,21)
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n/an/a 320n/an/an/an/a7.230



Universitat Hamburg



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 22-36 (2004)


Article DOI: 10.1021/jm0308904
BindingDB Entry DOI: 10.7270/Q28050TR
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7319
PNG
(6-Oxo-5,6,7,12-tetrahydro-indolo[3,2-d][1]benzazep...)
Show SMILES O=C1Cc2c([nH]c3ccccc23)-c2cc(ccc2N1)C#N
Show InChI InChI=1S/C17H11N3O/c18-9-10-5-6-15-13(7-10)17-12(8-16(21)19-15)11-3-1-2-4-14(11)20-17/h1-7,20H,8H2,(H,19,21)
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n/an/a 3.30E+3n/an/an/an/a7.230



Universitat Hamburg



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 22-36 (2004)


Article DOI: 10.1021/jm0308904
BindingDB Entry DOI: 10.7270/Q28050TR
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7320
PNG
(3-Methoxy-9-trifluormethyl-7,12-dihydro-indolo[3,2...)
Show SMILES COc1ccc2-c3[nH]c4ccc(cc4c3CC(=O)Nc2c1)C(F)(F)F
Show InChI InChI=1S/C18H13F3N2O2/c1-25-10-3-4-11-15(7-10)22-16(24)8-13-12-6-9(18(19,20)21)2-5-14(12)23-17(11)13/h2-7,23H,8H2,1H3,(H,22,24)
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n/an/a 700n/an/an/an/a7.230



Universitat Hamburg



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 22-36 (2004)


Article DOI: 10.1021/jm0308904
BindingDB Entry DOI: 10.7270/Q28050TR
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7321
PNG
(14-amino-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...)
Show SMILES Nc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1
Show InChI InChI=1S/C16H13N3O/c17-9-5-6-14-11(7-9)12-8-15(20)18-13-4-2-1-3-10(13)16(12)19-14/h1-7,19H,8,17H2,(H,18,20)
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n/an/a 2.00E+4n/an/an/an/a7.230



Universitat Hamburg



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 22-36 (2004)


Article DOI: 10.1021/jm0308904
BindingDB Entry DOI: 10.7270/Q28050TR
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7322
PNG
(14-bromo-5-hydroxy-8,18-diazatetracyclo[9.7.0.0^{2...)
Show SMILES Oc1ccc2-c3[nH]c4ccc(Br)cc4c3CC(=O)Nc2c1
Show InChI InChI=1S/C16H11BrN2O2/c17-8-1-4-13-11(5-8)12-7-15(21)18-14-6-9(20)2-3-10(14)16(12)19-13/h1-6,19-20H,7H2,(H,18,21)
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n/an/a 600n/an/an/an/a7.230



Universitat Hamburg



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 22-36 (2004)


Article DOI: 10.1021/jm0308904
BindingDB Entry DOI: 10.7270/Q28050TR
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7323
PNG
(9-Acetamido-7,12-dihydro-indolo[3,2-d][1]benzazepi...)
Show SMILES CC(=O)Nc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1
Show InChI InChI=1S/C18H15N3O2/c1-10(22)19-11-6-7-16-13(8-11)14-9-17(23)20-15-5-3-2-4-12(15)18(14)21-16/h2-8,21H,9H2,1H3,(H,19,22)(H,20,23)
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PubMed
n/an/a 1.30E+3n/an/an/an/a7.230



Universitat Hamburg



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 22-36 (2004)


Article DOI: 10.1021/jm0308904
BindingDB Entry DOI: 10.7270/Q28050TR
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7324
PNG
(14-methoxy-6,8,18-triazatetracyclo[9.7.0.0^{2,7}.0...)
Show SMILES COc1ccc2[nH]c-3c(CC(=O)Nc4ncccc-34)c2c1
Show InChI InChI=1S/C16H13N3O2/c1-21-9-4-5-13-11(7-9)12-8-14(20)19-16-10(15(12)18-13)3-2-6-17-16/h2-7,18H,8H2,1H3,(H,17,19,20)
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PubMed
n/an/a 9.00E+4n/an/an/an/a7.230



Universitat Hamburg



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 22-36 (2004)


Article DOI: 10.1021/jm0308904
BindingDB Entry DOI: 10.7270/Q28050TR
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7325
PNG
(2-(2-oxopropyl)-9-(trifluoromethyl)-7,12-dihydroin...)
Show SMILES CC(=O)Cc1ccc2NC(=O)Cc3c([nH]c4ccc(cc34)C(F)(F)F)-c2c1
Show InChI InChI=1S/C20H15F3N2O2/c1-10(26)6-11-2-4-17-15(7-11)19-14(9-18(27)24-17)13-8-12(20(21,22)23)3-5-16(13)25-19/h2-5,7-8,25H,6,9H2,1H3,(H,24,27)
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n/an/a 200n/an/an/an/a7.230



Universitat Hamburg



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 22-36 (2004)


Article DOI: 10.1021/jm0308904
BindingDB Entry DOI: 10.7270/Q28050TR
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7326
PNG
(14-chloro-6,8,18-triazatetracyclo[9.7.0.0^{2,7}.0^...)
Show SMILES Clc1ccc2[nH]c-3c(CC(=O)Nc4ncccc-34)c2c1
Show InChI InChI=1S/C15H10ClN3O/c16-8-3-4-12-10(6-8)11-7-13(20)19-15-9(14(11)18-12)2-1-5-17-15/h1-6,18H,7H2,(H,17,19,20)
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n/an/a 2.30E+4n/an/an/an/a7.230



Universitat Hamburg



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 22-36 (2004)


Article DOI: 10.1021/jm0308904
BindingDB Entry DOI: 10.7270/Q28050TR
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7327
PNG
(14-(trifluoromethyl)-6,8,18-triazatetracyclo[9.7.0...)
Show SMILES FC(F)(F)c1ccc2[nH]c-3c(CC(=O)Nc4ncccc-34)c2c1
Show InChI InChI=1S/C16H10F3N3O/c17-16(18,19)8-3-4-12-10(6-8)11-7-13(23)22-15-9(14(11)21-12)2-1-5-20-15/h1-6,21H,7H2,(H,20,22,23)
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PubMed
n/an/a 6.00E+3n/an/an/an/a7.230



Universitat Hamburg



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 22-36 (2004)


Article DOI: 10.1021/jm0308904
BindingDB Entry DOI: 10.7270/Q28050TR
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7328
PNG
(3-Methoxy-6-oxo-5,6,7,12-tetrahydro-indolo[3,2-d][...)
Show SMILES COc1ccc2-c3[nH]c4ccc(cc4c3CC(=O)Nc2c1)C#N
Show InChI InChI=1S/C18H13N3O2/c1-23-11-3-4-12-16(7-11)20-17(22)8-14-13-6-10(9-19)2-5-15(13)21-18(12)14/h2-7,21H,8H2,1H3,(H,20,22)
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n/an/a 1.20E+3n/an/an/an/a7.230



Universitat Hamburg



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 22-36 (2004)


Article DOI: 10.1021/jm0308904
BindingDB Entry DOI: 10.7270/Q28050TR
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7329
PNG
(3-Methoxy-9-nitro-7,12-dihydro-indolo[3,2-d][1]ben...)
Show SMILES COc1ccc2-c3[nH]c4ccc(cc4c3CC(=O)Nc2c1)[N+]([O-])=O
Show InChI InChI=1S/C17H13N3O4/c1-24-10-3-4-11-15(7-10)18-16(21)8-13-12-6-9(20(22)23)2-5-14(12)19-17(11)13/h2-7,19H,8H2,1H3,(H,18,21)
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n/an/a 1.00E+3n/an/an/an/a7.230



Universitat Hamburg



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 22-36 (2004)


Article DOI: 10.1021/jm0308904
BindingDB Entry DOI: 10.7270/Q28050TR
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7330
PNG
(2-Methoxy-9-nitro-7,12-dihydro-indolo[3,2-d][1]ben...)
Show SMILES COc1ccc2NC(=O)Cc3c([nH]c4ccc(cc34)[N+]([O-])=O)-c2c1
Show InChI InChI=1S/C17H13N3O4/c1-24-10-3-5-15-13(7-10)17-12(8-16(21)18-15)11-6-9(20(22)23)2-4-14(11)19-17/h2-7,19H,8H2,1H3,(H,18,21)
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n/an/a 80n/an/an/an/a7.230



Universitat Hamburg



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 22-36 (2004)


Article DOI: 10.1021/jm0308904
BindingDB Entry DOI: 10.7270/Q28050TR
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7331
PNG
(14-methyl-6,8,18-triazatetracyclo[9.7.0.0^{2,7}.0^...)
Show SMILES Cc1ccc2[nH]c-3c(CC(=O)Nc4ncccc-34)c2c1
Show InChI InChI=1S/C16H13N3O/c1-9-4-5-13-11(7-9)12-8-14(20)19-16-10(15(12)18-13)3-2-6-17-16/h2-7,18H,8H2,1H3,(H,17,19,20)
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n/an/a 2.00E+5n/an/an/an/a7.230



Universitat Hamburg



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 22-36 (2004)


Article DOI: 10.1021/jm0308904
BindingDB Entry DOI: 10.7270/Q28050TR
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7332
PNG
(7,12-Dihydro-pyrido[3 ,2 :4,5]pyrrolo[3,2-d][1]ben...)
Show SMILES O=C1Cc2c([nH]c3ncccc23)-c2ccccc2N1
Show InChI InChI=1S/C15H11N3O/c19-13-8-11-9-5-3-7-16-15(9)18-14(11)10-4-1-2-6-12(10)17-13/h1-7H,8H2,(H,16,18)(H,17,19)
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n/an/a 2.20E+3n/an/an/an/a7.230



Universitat Hamburg



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 47: 22-36 (2004)


Article DOI: 10.1021/jm0308904
BindingDB Entry DOI: 10.7270/Q28050TR
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7341
PNG
(6-Phenyl[5H]pyrrolo[2,3-b]pyrazine | 6-phenyl-5H-p...)
Show SMILES c1c([nH]c2nccnc12)-c1ccccc1
Show InChI InChI=1S/C12H9N3/c1-2-4-9(5-3-1)10-8-11-12(15-10)14-7-6-13-11/h1-8H,(H,14,15)
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PubMed
n/an/a 5.00E+3n/an/an/an/a7.230



Faculte de Medecine et de Pharmacie



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 46: 222-36 (2003)


Article DOI: 10.1021/jm020319p
BindingDB Entry DOI: 10.7270/Q2474820
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7342
PNG
(6-(2-Methoxyphenyl)[5H]pyrrolo[2,3-b]pyrazine | 6-...)
Show SMILES COc1ccccc1-c1cc2nccnc2[nH]1
Show InChI InChI=1S/C13H11N3O/c1-17-12-5-3-2-4-9(12)10-8-11-13(16-10)15-7-6-14-11/h2-8H,1H3,(H,15,16)
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n/an/a 2.00E+4n/an/an/an/a7.230



Faculte de Medecine et de Pharmacie



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 46: 222-36 (2003)


Article DOI: 10.1021/jm020319p
BindingDB Entry DOI: 10.7270/Q2474820
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7343
PNG
(2-{5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol | 6-phenyl...)
Show SMILES Oc1ccccc1-c1cc2nccnc2[nH]1
Show InChI InChI=1S/C12H9N3O/c16-11-4-2-1-3-8(11)9-7-10-12(15-9)14-6-5-13-10/h1-7,16H,(H,14,15)
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PubMed
n/an/a 2.50E+3n/an/an/an/a7.230



Faculte de Medecine et de Pharmacie



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 46: 222-36 (2003)


Article DOI: 10.1021/jm020319p
BindingDB Entry DOI: 10.7270/Q2474820
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7344
PNG
(6-(3-Methoxyphenyl)[5H]pyrrolo[2,3-b]pyrazine | 6-...)
Show SMILES COc1cccc(c1)-c1cc2nccnc2[nH]1
Show InChI InChI=1S/C13H11N3O/c1-17-10-4-2-3-9(7-10)11-8-12-13(16-11)15-6-5-14-12/h2-8H,1H3,(H,15,16)
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n/an/a 1.30E+4n/an/an/an/a7.230



Faculte de Medecine et de Pharmacie



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 46: 222-36 (2003)


Article DOI: 10.1021/jm020319p
BindingDB Entry DOI: 10.7270/Q2474820
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7345
PNG
(3-{5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol | 6-phenyl...)
Show SMILES Oc1cccc(c1)-c1cc2nccnc2[nH]1
Show InChI InChI=1S/C12H9N3O/c16-9-3-1-2-8(6-9)10-7-11-12(15-10)14-5-4-13-11/h1-7,16H,(H,14,15)
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n/an/a 2.50E+3n/an/an/an/a7.230



Faculte de Medecine et de Pharmacie



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 46: 222-36 (2003)


Article DOI: 10.1021/jm020319p
BindingDB Entry DOI: 10.7270/Q2474820
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7346
PNG
(6-(4-Methoxyphenyl)[5H]pyrrolo[2,3-b]pyrazine | 6-...)
Show SMILES COc1ccc(cc1)-c1cc2nccnc2[nH]1
Show InChI InChI=1S/C13H11N3O/c1-17-10-4-2-9(3-5-10)11-8-12-13(16-11)15-7-6-14-12/h2-8H,1H3,(H,15,16)
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n/an/a 2.00E+3n/an/an/an/a7.230



Faculte de Medecine et de Pharmacie



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 46: 222-36 (2003)


Article DOI: 10.1021/jm020319p
BindingDB Entry DOI: 10.7270/Q2474820
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7347
PNG
(4-{5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol | 6-phenyl...)
Show SMILES Oc1ccc(cc1)-c1cc2nccnc2[nH]1
Show InChI InChI=1S/C12H9N3O/c16-9-3-1-8(2-4-9)10-7-11-12(15-10)14-6-5-13-11/h1-7,16H,(H,14,15)
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PubMed
n/an/a 1.20E+3n/an/an/an/a7.230



Faculte de Medecine et de Pharmacie



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 46: 222-36 (2003)


Article DOI: 10.1021/jm020319p
BindingDB Entry DOI: 10.7270/Q2474820
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7348
PNG
(6-(3,5-Dimethoxyphenyl)[5H]pyrrolo[2,3-b]pyrazine ...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2nccnc2[nH]1
Show InChI InChI=1S/C14H13N3O2/c1-18-10-5-9(6-11(7-10)19-2)12-8-13-14(17-12)16-4-3-15-13/h3-8H,1-2H3,(H,16,17)
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n/an/a 1.00E+5n/an/an/an/a7.230



Faculte de Medecine et de Pharmacie



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 46: 222-36 (2003)


Article DOI: 10.1021/jm020319p
BindingDB Entry DOI: 10.7270/Q2474820
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7349
PNG
(6-(3,4,5-Trimethoxyphenyl)[5H]pyrrolo[2,3-b]pyrazi...)
Show SMILES COc1cc(cc(OC)c1OC)-c1cc2nccnc2[nH]1
Show InChI InChI=1S/C15H15N3O3/c1-19-12-6-9(7-13(20-2)14(12)21-3)10-8-11-15(18-10)17-5-4-16-11/h4-8H,1-3H3,(H,17,18)
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n/an/a 1.00E+5n/an/an/an/a7.230



Faculte de Medecine et de Pharmacie



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 46: 222-36 (2003)


Article DOI: 10.1021/jm020319p
BindingDB Entry DOI: 10.7270/Q2474820
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7350
PNG
(6-(4-Fluorophenyl)[5H]pyrrolo[2,3-b]pyrazine | 6-(...)
Show SMILES Fc1ccc(cc1)-c1cc2nccnc2[nH]1
Show InChI InChI=1S/C12H8FN3/c13-9-3-1-8(2-4-9)10-7-11-12(16-10)15-6-5-14-11/h1-7H,(H,15,16)
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n/an/a 2.30E+3n/an/an/an/a7.230



Faculte de Medecine et de Pharmacie



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 46: 222-36 (2003)


Article DOI: 10.1021/jm020319p
BindingDB Entry DOI: 10.7270/Q2474820
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7351
PNG
(6-(4-Chlorophenyl)[5H]pyrrolo[2,3-b]pyrazine | 6-(...)
Show SMILES Clc1ccc(cc1)-c1cc2nccnc2[nH]1
Show InChI InChI=1S/C12H8ClN3/c13-9-3-1-8(2-4-9)10-7-11-12(16-10)15-6-5-14-11/h1-7H,(H,15,16)
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PubMed
n/an/a 1.80E+3n/an/an/an/a7.230



Faculte de Medecine et de Pharmacie



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 46: 222-36 (2003)


Article DOI: 10.1021/jm020319p
BindingDB Entry DOI: 10.7270/Q2474820
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7352
PNG
(6-(3,5-Dichlorophenyl)[5H]pyrrolo[2,3-b]pyrazine |...)
Show SMILES Clc1cc(Cl)cc(c1)-c1cc2nccnc2[nH]1
Show InChI InChI=1S/C12H7Cl2N3/c13-8-3-7(4-9(14)5-8)10-6-11-12(17-10)16-2-1-15-11/h1-6H,(H,16,17)
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n/an/a>1.00E+5n/an/an/an/a7.230



Faculte de Medecine et de Pharmacie



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 46: 222-36 (2003)


Article DOI: 10.1021/jm020319p
BindingDB Entry DOI: 10.7270/Q2474820
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7353
PNG
(6-(4-Bromophenyl)[5H]pyrrolo[2,3-b]pyrazine | 6-(4...)
Show SMILES Brc1ccc(cc1)-c1cc2nccnc2[nH]1
Show InChI InChI=1S/C12H8BrN3/c13-9-3-1-8(2-4-9)10-7-11-12(16-10)15-6-5-14-11/h1-7H,(H,15,16)
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Article
PubMed
n/an/a 4.00E+3n/an/an/an/a7.230



Faculte de Medecine et de Pharmacie



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 46: 222-36 (2003)


Article DOI: 10.1021/jm020319p
BindingDB Entry DOI: 10.7270/Q2474820
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7354
PNG
(6-(4-Trifluoromethylphenyl)[5H]pyrrolo[2,3-b]pyraz...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cc2nccnc2[nH]1
Show InChI InChI=1S/C13H8F3N3/c14-13(15,16)9-3-1-8(2-4-9)10-7-11-12(19-10)18-6-5-17-11/h1-7H,(H,18,19)
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PubMed
n/an/a 6.00E+3n/an/an/an/a7.230



Faculte de Medecine et de Pharmacie



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 46: 222-36 (2003)


Article DOI: 10.1021/jm020319p
BindingDB Entry DOI: 10.7270/Q2474820
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7355
PNG
(4-{5H-pyrrolo[2,3-b]pyrazin-6-yl}benzonitrile | 6-...)
Show SMILES N#Cc1ccc(cc1)-c1cc2nccnc2[nH]1
Show InChI InChI=1S/C13H8N4/c14-8-9-1-3-10(4-2-9)11-7-12-13(17-11)16-6-5-15-12/h1-7H,(H,16,17)
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PubMed
n/an/a 3.00E+3n/an/an/an/a7.230



Faculte de Medecine et de Pharmacie



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 46: 222-36 (2003)


Article DOI: 10.1021/jm020319p
BindingDB Entry DOI: 10.7270/Q2474820
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7356
PNG
(6-(4-Methylphenyl)[5H]pyrrolo[2,3-b]pyrazine | 6-(...)
Show SMILES Cc1ccc(cc1)-c1cc2nccnc2[nH]1
Show InChI InChI=1S/C13H11N3/c1-9-2-4-10(5-3-9)11-8-12-13(16-11)15-7-6-14-12/h2-8H,1H3,(H,15,16)
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PubMed
n/an/a 3.00E+3n/an/an/an/a7.230



Faculte de Medecine et de Pharmacie



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 46: 222-36 (2003)


Article DOI: 10.1021/jm020319p
BindingDB Entry DOI: 10.7270/Q2474820
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7474
PNG
(4-phenyl-1H-pyrazolo[3,4-c]pyridazin-3-amine | Pyr...)
Show SMILES Nc1n[nH]c2nncc(-c3ccccc3)c12
Show InChI InChI=1S/C11H9N5/c12-10-9-8(7-4-2-1-3-5-7)6-13-15-11(9)16-14-10/h1-6H,(H3,12,14,15,16)
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PubMed
n/an/a>5.00E+4n/an/an/an/a7.230



Universidad San Pablo CEU



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-33P] ATP. 33...


J Med Chem 48: 6843-54 (2005)


Article DOI: 10.1021/jm058013g
BindingDB Entry DOI: 10.7270/Q2GH9G44
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7475
PNG
(3-Amino-4,5-bis(p-aminophenyl)-1H-pyrazolo[3,4-c]-...)
Show SMILES Nc1n[nH]c2nnc(-c3ccc(N)cc3)c(-c3ccc(N)cc3)c12
Show InChI InChI=1S/C17H15N7/c18-11-5-1-9(2-6-11)13-14-16(20)22-24-17(14)23-21-15(13)10-3-7-12(19)8-4-10/h1-8H,18-19H2,(H3,20,22,23,24)
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n/an/a>5.00E+4n/an/an/an/a7.230



Universidad San Pablo CEU



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-33P] ATP. 33...


J Med Chem 48: 6843-54 (2005)


Article DOI: 10.1021/jm058013g
BindingDB Entry DOI: 10.7270/Q2GH9G44
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7476
PNG
(3-Amino-5-phenyl-1H-pyrazolo[3,4-c]pyridazine | 5-...)
Show SMILES Nc1n[nH]c2nnc(cc12)-c1ccccc1
Show InChI InChI=1S/C11H9N5/c12-10-8-6-9(7-4-2-1-3-5-7)13-15-11(8)16-14-10/h1-6H,(H3,12,14,15,16)
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Article
PubMed
n/an/a 4.00E+3n/an/an/an/a7.230



Universidad San Pablo CEU



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-33P] ATP. 33...


J Med Chem 48: 6843-54 (2005)


Article DOI: 10.1021/jm058013g
BindingDB Entry DOI: 10.7270/Q2GH9G44
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Marthasterias glacialis (starfish))
BDBM7491
PNG
((4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-yl...)
Show SMILES NC1=NC(=O)C(N1)=C1CCNC(=O)c2[nH]c(Br)cc12
Show InChI InChI=1S/C11H10BrN5O2/c12-6-3-5-4(7-10(19)17-11(13)16-7)1-2-14-9(18)8(5)15-6/h3,15H,1-2H2,(H,14,18)(H3,13,16,17,19)
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PubMed
n/an/a 22n/an/an/an/a7.230



Technische Universitat Braunschweig



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Bioorg Med Chem Lett 14: 413-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.062
BindingDB Entry DOI: 10.7270/Q2BR8QDD
More data for this
Ligand-Target Pair
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