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Found 324 hits Enz. Inhib. hit(s) with Target = 'Cyclin-dependent kinase 6'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-Dependent Kinase 6 (CDK6)


(Homo sapiens (human)-Saimiriine herpesvirus 2)
BDBM7457
PNG
(2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4H-chromen-4...)
Show SMILES Oc1ccc2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O
Show InChI InChI=1S/C15H10O6/c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7/h1-6,16-18,20H
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Article
PubMed
n/an/a 850n/an/an/an/a7.030



Lawrence Berkeley National Laboratory



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 48: 737-43 (2005)


Article DOI: 10.1021/jm049353p
BindingDB Entry DOI: 10.7270/Q2M61HG4
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cyclin-Dependent Kinase 6 (CDK6)


(Homo sapiens (human)-Saimiriine herpesvirus 2)
BDBM7458
PNG
(5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one...)
Show SMILES Oc1ccc(cc1)-c1cc(=O)c2c(O)cc(O)cc2o1
Show InChI InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
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n/an/a 1.70E+3n/an/an/an/a7.030



Lawrence Berkeley National Laboratory



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 48: 737-43 (2005)


Article DOI: 10.1021/jm049353p
BindingDB Entry DOI: 10.7270/Q2M61HG4
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Cyclin-Dependent Kinase 6 (CDK6)


(Homo sapiens (human)-Saimiriine herpesvirus 2)
BDBM7459
PNG
(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Show SMILES Oc1cc(O)c2c(c1)oc(cc2=O)-c1ccc(O)c(O)c1
Show InChI InChI=1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H
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n/an/a>3.00E+5n/an/an/an/a7.030



Lawrence Berkeley National Laboratory



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 48: 737-43 (2005)


Article DOI: 10.1021/jm049353p
BindingDB Entry DOI: 10.7270/Q2M61HG4
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Cyclin-Dependent Kinase 6 (CDK6)


(Homo sapiens (human)-Saimiriine herpesvirus 2)
BDBM5655
PNG
(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Show SMILES CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl
Show InChI InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1
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n/an/a 80n/an/an/an/a7.030



Lawrence Berkeley National Laboratory



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 48: 737-43 (2005)


Article DOI: 10.1021/jm049353p
BindingDB Entry DOI: 10.7270/Q2M61HG4
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Cyclin-Dependent Kinase 6 (CDK6)


(Homo sapiens (human)-Saimiriine herpesvirus 2)
BDBM7461
PNG
(5,7-dihydroxy-2-phenyl-4H-chromen-4-one | 5,7-dihy...)
Show SMILES Oc1cc(O)c2c(c1)oc(cc2=O)-c1ccccc1
Show InChI InChI=1S/C15H10O4/c16-10-6-11(17)15-12(18)8-13(19-14(15)7-10)9-4-2-1-3-5-9/h1-8,16-17H
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n/an/a 6.00E+3n/an/an/an/a7.030



Lawrence Berkeley National Laboratory



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 48: 737-43 (2005)


Article DOI: 10.1021/jm049353p
BindingDB Entry DOI: 10.7270/Q2M61HG4
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Cyclin-Dependent Kinase 6 (CDK6)


(Homo sapiens (human)-Saimiriine herpesvirus 2)
BDBM7462
PNG
(3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-...)
Show SMILES Oc1ccc(cc1)-c1oc2cc(O)cc(O)c2c(=O)c1O
Show InChI InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H
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n/an/a 2.20E+4n/an/an/an/a7.030



Lawrence Berkeley National Laboratory



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 48: 737-43 (2005)


Article DOI: 10.1021/jm049353p
BindingDB Entry DOI: 10.7270/Q2M61HG4
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Cyclin-Dependent Kinase 6 (CDK6)


(Homo sapiens (human)-Saimiriine herpesvirus 2)
BDBM7460
PNG
(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)
Show SMILES Oc1cc(O)c2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O
Show InChI InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H
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n/an/a 2.50E+4n/an/an/an/a7.030



Lawrence Berkeley National Laboratory



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 48: 737-43 (2005)


Article DOI: 10.1021/jm049353p
BindingDB Entry DOI: 10.7270/Q2M61HG4
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Cyclin-Dependent Kinase 6 (CDK6)


(Homo sapiens (human))
BDBM6619
PNG
(3-[(9bR)-5-oxo-1H,2H,3H,5H,9bH-benzo[a]pyrrolizin-...)
Show SMILES O=C(Nc1ccccn1)Nc1cccc2C(=O)N3CCC[C@@H]3c12
Show InChI InChI=1S/C17H16N4O2/c22-16-11-5-3-6-12(15(11)13-7-4-10-21(13)16)19-17(23)20-14-8-1-2-9-18-14/h1-3,5-6,8-9,13H,4,7,10H2,(H2,18,19,20,23)/t13-/m1/s1
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n/an/a 71n/an/an/an/a7.430



Banyu Tsukuba Research Institute



Assay Description
In vitro kinase assays using synthetic peptides and purified enzymes were incubated at 30°C for 20 min in buffer that contained 50 uM ATP, and d...


J Med Chem 44: 4628-40 (2001)


Article DOI: 10.1021/jm010326y
BindingDB Entry DOI: 10.7270/Q2BV7DS8
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM50001584
PNG
(CHEMBL3237442 | US8841312, 1)
Show SMILES C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12
Show InChI InChI=1S/C23H26N8/c1-2-4-16(3-1)31-20-15-25-8-7-18(20)19-14-27-23(29-22(19)31)28-21-6-5-17(13-26-21)30-11-9-24-10-12-30/h5-8,13-16,24H,1-4,9-12H2,(H,26,27,28,29)
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n/an/a 4.40n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132260
PNG
(US8841312, 2)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nc1
Show InChI InChI=1S/C24H28N8/c1-30-10-12-31(13-11-30)18-6-7-22(26-14-18)28-24-27-15-20-19-8-9-25-16-21(19)32(23(20)29-24)17-4-2-3-5-17/h6-9,14-17H,2-5,10-13H2,1H3,(H,26,27,28,29)
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n/an/a 10n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132261
PNG
(US8841312, 3)
Show SMILES C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(cc3)N3CCNCC3)nc12
Show InChI InChI=1S/C24H27N7/c1-2-4-19(3-1)31-22-16-26-10-9-20(22)21-15-27-24(29-23(21)31)28-17-5-7-18(8-6-17)30-13-11-25-12-14-30/h5-10,15-16,19,25H,1-4,11-14H2,(H,27,28,29)
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n/an/a 2.90n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132262
PNG
(US8841312, 4)
Show SMILES C[C@@H]1CN(CCN1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1
Show InChI InChI=1S/C23H27N9/c1-15-14-31(11-10-25-15)21-7-6-20(29-30-21)27-23-26-12-18-17-8-9-24-13-19(17)32(22(18)28-23)16-4-2-3-5-16/h6-9,12-13,15-16,25H,2-5,10-11,14H2,1H3,(H,26,27,28,29)/t15-/m1/s1
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n/an/a 11.5n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132263
PNG
(US8841312, 5)
Show SMILES Cc1cc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)cnc1N1CCNCC1
Show InChI InChI=1S/C24H28N8/c1-16-12-17(13-27-22(16)31-10-8-25-9-11-31)29-24-28-14-20-19-6-7-26-15-21(19)32(23(20)30-24)18-4-2-3-5-18/h6-7,12-15,18,25H,2-5,8-11H2,1H3,(H,28,29,30)
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n/an/a 4.20n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132264
PNG
(US8841312, 6)
Show SMILES C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(nn3)N3CCNCC3)nc12
Show InChI InChI=1S/C22H25N9/c1-2-4-15(3-1)31-18-14-24-8-7-16(18)17-13-25-22(27-21(17)31)26-19-5-6-20(29-28-19)30-11-9-23-10-12-30/h5-8,13-15,23H,1-4,9-12H2,(H,25,26,27,28)
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n/an/a 6.60n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132265
PNG
(US8841312, 7)
Show SMILES C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(nc3)N3CCNCC3)nc12
Show InChI InChI=1S/C23H26N8/c1-2-4-17(3-1)31-20-15-25-8-7-18(20)19-14-27-23(29-22(19)31)28-16-5-6-21(26-13-16)30-11-9-24-10-12-30/h5-8,13-15,17,24H,1-4,9-12H2,(H,27,28,29)
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n/an/a 1.30n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132266
PNG
(US8841312, 8)
Show SMILES C1CCC(C1)n1c2cnccc2c2cnc(Nc3cnc(nc3)N3CCNCC3)nc12
Show InChI InChI=1S/C22H25N9/c1-2-4-16(3-1)31-19-14-24-6-5-17(19)18-13-25-21(29-20(18)31)28-15-11-26-22(27-12-15)30-9-7-23-8-10-30/h5-6,11-14,16,23H,1-4,7-10H2,(H,25,28,29)
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n/an/a 1.10n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132267
PNG
(US8841312, 9)
Show SMILES C[C@H]1CN(CCN1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1
Show InChI InChI=1S/C23H27N9/c1-15-14-31(11-10-25-15)21-7-6-20(29-30-21)27-23-26-12-18-17-8-9-24-13-19(17)32(22(18)28-23)16-4-2-3-5-16/h6-9,12-13,15-16,25H,2-5,10-11,14H2,1H3,(H,26,27,28,29)/t15-/m0/s1
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n/an/a 19.5n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132269
PNG
(US8841312, 11)
Show SMILES NC1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1
Show InChI InChI=1S/C24H28N8/c25-16-8-11-31(12-9-16)18-5-6-22(27-13-18)29-24-28-14-20-19-7-10-26-15-21(19)32(23(20)30-24)17-3-1-2-4-17/h5-7,10,13-17H,1-4,8-9,11-12,25H2,(H,27,28,29,30)
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n/an/a 10n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132271
PNG
(US8841312, 13)
Show SMILES CN(C)C1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nn1
Show InChI InChI=1S/C25H31N9/c1-32(2)17-10-13-33(14-11-17)23-8-7-22(30-31-23)28-25-27-15-20-19-9-12-26-16-21(19)34(24(20)29-25)18-5-3-4-6-18/h7-9,12,15-18H,3-6,10-11,13-14H2,1-2H3,(H,27,28,29,30)
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n/an/a 2.60n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132272
PNG
(US8841312, 14)
Show SMILES C1CN(CCN1)c1ccc(Nc2ncc3c(n2)n(-c2ccccc2)c2cnccc32)nc1
Show InChI InChI=1S/C24H22N8/c1-2-4-17(5-3-1)32-21-16-26-9-8-19(21)20-15-28-24(30-23(20)32)29-22-7-6-18(14-27-22)31-12-10-25-11-13-31/h1-9,14-16,25H,10-13H2,(H,27,28,29,30)
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n/an/a 8n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132273
PNG
(US8841312, 15)
Show SMILES Fc1ccc(cc1)-n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12
Show InChI InChI=1S/C24H21FN8/c25-16-1-3-17(4-2-16)33-21-15-27-8-7-19(21)20-14-29-24(31-23(20)33)30-22-6-5-18(13-28-22)32-11-9-26-10-12-32/h1-8,13-15,26H,9-12H2,(H,28,29,30,31)
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n/an/a 13n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132274
PNG
(US8841312, 16)
Show SMILES COc1ccc(cc1)-n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12
Show InChI InChI=1S/C25H24N8O/c1-34-19-5-2-17(3-6-19)33-22-16-27-9-8-20(22)21-15-29-25(31-24(21)33)30-23-7-4-18(14-28-23)32-12-10-26-11-13-32/h2-9,14-16,26H,10-13H2,1H3,(H,28,29,30,31)
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n/an/a 21n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132275
PNG
(US8841312, 17)
Show SMILES C1CN(CCN1)c1ccc(Nc2ncc3c(n2)n(-c2ccccc2)c2cnccc32)cc1
Show InChI InChI=1S/C25H23N7/c1-2-4-20(5-3-1)32-23-17-27-11-10-21(23)22-16-28-25(30-24(22)32)29-18-6-8-19(9-7-18)31-14-12-26-13-15-31/h1-11,16-17,26H,12-15H2,(H,28,29,30)
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n/an/a 0.360n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132276
PNG
(US8841312, 18)
Show SMILES O[C@@H]1CCN(C1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nn1
Show InChI InChI=1S/C22H24N8O/c31-15-8-10-29(13-15)20-6-5-19(27-28-20)25-22-24-11-17-16-7-9-23-12-18(16)30(21(17)26-22)14-3-1-2-4-14/h5-7,9,11-12,14-15,31H,1-4,8,10,13H2,(H,24,25,26,27)/t15-/m1/s1
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n/an/a 1.5n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132277
PNG
(US8841312, 19)
Show SMILES O[C@H]1CCN(C1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nn1
Show InChI InChI=1S/C22H24N8O/c31-15-8-10-29(13-15)20-6-5-19(27-28-20)25-22-24-11-17-16-7-9-23-12-18(16)30(21(17)26-22)14-3-1-2-4-14/h5-7,9,11-12,14-15,31H,1-4,8,10,13H2,(H,24,25,26,27)/t15-/m0/s1
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n/an/a 10n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132278
PNG
(US8841312, 20)
Show SMILES C1CN(CCN1)c1ccc(Nc2ncc3c(n2)n(C2CCOCC2)c2cnccc32)nc1
Show InChI InChI=1S/C23H26N8O/c1-2-21(26-13-17(1)30-9-7-24-8-10-30)28-23-27-14-19-18-3-6-25-15-20(18)31(22(19)29-23)16-4-11-32-12-5-16/h1-3,6,13-16,24H,4-5,7-12H2,(H,26,27,28,29)
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n/an/a 57n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132279
PNG
(US8841312, 21)
Show SMILES C1CCC(CC1)n1c2ccccc2c2cnc(Nc3ccc(cc3)N3CCNCC3)nc12
Show InChI InChI=1S/C26H30N6/c1-2-6-21(7-3-1)32-24-9-5-4-8-22(24)23-18-28-26(30-25(23)32)29-19-10-12-20(13-11-19)31-16-14-27-15-17-31/h4-5,8-13,18,21,27H,1-3,6-7,14-17H2,(H,28,29,30)
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n/an/a 0.410n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132280
PNG
(US8841312, 22)
Show SMILES C1CCC(CC1)n1c2ccccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12
Show InChI InChI=1S/C25H29N7/c1-2-6-18(7-3-1)32-22-9-5-4-8-20(22)21-17-28-25(30-24(21)32)29-23-11-10-19(16-27-23)31-14-12-26-13-15-31/h4-5,8-11,16-18,26H,1-3,6-7,12-15H2,(H,27,28,29,30)
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n/an/a 2.5n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM50001536
PNG
(CHEMBL3237451 | US8841312, 23)
Show SMILES C1CCC(CC1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12
Show InChI InChI=1S/C24H28N8/c1-2-4-17(5-3-1)32-21-16-26-9-8-19(21)20-15-28-24(30-23(20)32)29-22-7-6-18(14-27-22)31-12-10-25-11-13-31/h6-9,14-17,25H,1-5,10-13H2,(H,27,28,29,30)
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n/an/a 13.1n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132281
PNG
(US8841312, 24)
Show SMILES C1CC2CC1CC2n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12
Show InChI InChI=1S/C25H28N8/c1-2-17-11-16(1)12-21(17)33-22-15-27-6-5-19(22)20-14-29-25(31-24(20)33)30-23-4-3-18(13-28-23)32-9-7-26-8-10-32/h3-6,13-17,21,26H,1-2,7-12H2,(H,28,29,30,31)
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n/an/a 5.10n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132282
PNG
(US8841312, 25)
Show SMILES C1Cc2ccccc2C1n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12
Show InChI InChI=1S/C27H26N8/c1-2-4-20-18(3-1)5-7-23(20)35-24-17-29-10-9-21(24)22-16-31-27(33-26(22)35)32-25-8-6-19(15-30-25)34-13-11-28-12-14-34/h1-4,6,8-10,15-17,23,28H,5,7,11-14H2,(H,30,31,32,33)
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n/an/a 38n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132283
PNG
(US8841312, 26)
Show SMILES C1CN(CCN1)c1ccc(Nc2ncc3c(n2)n(c2cnccc32)C23CC4CC(CC(C4)C2)C3)nc1
Show InChI InChI=1S/C28H32N8/c1-2-25(31-15-21(1)35-7-5-29-6-8-35)33-27-32-16-23-22-3-4-30-17-24(22)36(26(23)34-27)28-12-18-9-19(13-28)11-20(10-18)14-28/h1-4,15-20,29H,5-14H2,(H,31,32,33,34)
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n/an/a 3.5n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132284
PNG
(US8841312, 27)
Show SMILES CC(C)(C)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12
Show InChI InChI=1S/C22H26N8/c1-22(2,3)30-18-14-24-7-6-16(18)17-13-26-21(28-20(17)30)27-19-5-4-15(12-25-19)29-10-8-23-9-11-29/h4-7,12-14,23H,8-11H2,1-3H3,(H,25,26,27,28)
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n/an/a 7n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132285
PNG
(US8841312, 28)
Show SMILES C[C@H](C1CCCCC1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12
Show InChI InChI=1S/C26H32N8/c1-18(19-5-3-2-4-6-19)34-23-17-28-10-9-21(23)22-16-30-26(32-25(22)34)31-24-8-7-20(15-29-24)33-13-11-27-12-14-33/h7-10,15-19,27H,2-6,11-14H2,1H3,(H,29,30,31,32)/t18-/m1/s1
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n/an/a 61n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132286
PNG
(US8841312, 29)
Show SMILES C[C@@H](C1CCCCC1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12
Show InChI InChI=1S/C26H32N8/c1-18(19-5-3-2-4-6-19)34-23-17-28-10-9-21(23)22-16-30-26(32-25(22)34)31-24-8-7-20(15-29-24)33-13-11-27-12-14-33/h7-10,15-19,27H,2-6,11-14H2,1H3,(H,29,30,31,32)/t18-/m0/s1
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n/an/a 5.70n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132287
PNG
(US8841312, 30)
Show SMILES C1CC(C1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12
Show InChI InChI=1S/C22H24N8/c1-2-15(3-1)30-19-14-24-7-6-17(19)18-13-26-22(28-21(18)30)27-20-5-4-16(12-25-20)29-10-8-23-9-11-29/h4-7,12-15,23H,1-3,8-11H2,(H,25,26,27,28)
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n/an/a 6.10n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132288
PNG
(US8841312, 31)
Show SMILES O[C@H]1CCC(CC1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12
Show InChI InChI=1S/C24H28N8O/c33-18-4-1-16(2-5-18)32-21-15-26-8-7-19(21)20-14-28-24(30-23(20)32)29-22-6-3-17(13-27-22)31-11-9-25-10-12-31/h3,6-8,13-16,18,25,33H,1-2,4-5,9-12H2,(H,27,28,29,30)/t16?,18-
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n/an/a 5.90n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132289
PNG
(US8841312, 32)
Show SMILES C(C1CCCCC1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12
Show InChI InChI=1S/C25H30N8/c1-2-4-18(5-3-1)17-33-22-16-27-9-8-20(22)21-15-29-25(31-24(21)33)30-23-7-6-19(14-28-23)32-12-10-26-11-13-32/h6-9,14-16,18,26H,1-5,10-13,17H2,(H,28,29,30,31)
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n/an/a 30.4n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132290
PNG
(US8841312, 33)
Show SMILES CC1(CCC1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12
Show InChI InChI=1S/C23H26N8/c1-23(6-2-7-23)31-19-15-25-8-5-17(19)18-14-27-22(29-21(18)31)28-20-4-3-16(13-26-20)30-11-9-24-10-12-30/h3-5,8,13-15,24H,2,6-7,9-12H2,1H3,(H,26,27,28,29)
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n/an/a 8.90n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132291
PNG
(US8841312, 34)
Show SMILES C1CN(CCN1)c1ccc(Nc2ncc3c(n2)n(C2CCCCCC2)c2cnccc32)nc1
Show InChI InChI=1S/C25H30N8/c1-2-4-6-18(5-3-1)33-22-17-27-10-9-20(22)21-16-29-25(31-24(21)33)30-23-8-7-19(15-28-23)32-13-11-26-12-14-32/h7-10,15-18,26H,1-6,11-14H2,(H,28,29,30,31)
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n/an/a 21n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132292
PNG
(US8841312, 35)
Show SMILES C1CCC(C1)n1c2ncccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12
Show InChI InChI=1S/C23H26N8/c1-2-5-16(4-1)31-21-18(6-3-9-25-21)19-15-27-23(29-22(19)31)28-20-8-7-17(14-26-20)30-12-10-24-11-13-30/h3,6-9,14-16,24H,1-2,4-5,10-13H2,(H,26,27,28,29)
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n/an/a 21n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132293
PNG
(US8841312, 36)
Show SMILES C1CCC(C1)n1c2ncccc2c2cnc(Nc3ccc(cc3)N3CCNCC3)nc12
Show InChI InChI=1S/C24H27N7/c1-2-5-19(4-1)31-22-20(6-3-11-26-22)21-16-27-24(29-23(21)31)28-17-7-9-18(10-8-17)30-14-12-25-13-15-30/h3,6-11,16,19,25H,1-2,4-5,12-15H2,(H,27,28,29)
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n/an/a 4.40n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132294
PNG
(US8841312, 37)
Show SMILES C1CCC(C1)n1c2ccccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12
Show InChI InChI=1S/C24H27N7/c1-2-6-17(5-1)31-21-8-4-3-7-19(21)20-16-27-24(29-23(20)31)28-22-10-9-18(15-26-22)30-13-11-25-12-14-30/h3-4,7-10,15-17,25H,1-2,5-6,11-14H2,(H,26,27,28,29)
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n/an/a 1.20n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132295
PNG
(US8841312, 38)
Show SMILES C1CN(CCN1)c1ccc(Nc2ncc3c(n2)n(C2CCOCC2)c2ccccc32)nc1
Show InChI InChI=1S/C24H27N7O/c1-2-4-21-19(3-1)20-16-27-24(29-23(20)31(21)17-7-13-32-14-8-17)28-22-6-5-18(15-26-22)30-11-9-25-10-12-30/h1-6,15-17,25H,7-14H2,(H,26,27,28,29)
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n/an/a 15.3n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132296
PNG
(US8841312, 39)
Show SMILES C1CN(CCN1)c1ccc(Nc2ncc3c(n2)n(C2CCCCCC2)c2ccccc32)nc1
Show InChI InChI=1S/C26H31N7/c1-2-4-8-19(7-3-1)33-23-10-6-5-9-21(23)22-18-29-26(31-25(22)33)30-24-12-11-20(17-28-24)32-15-13-27-14-16-32/h5-6,9-12,17-19,27H,1-4,7-8,13-16H2,(H,28,29,30,31)
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n/an/a 3.10n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132297
PNG
(US8841312, 40)
Show SMILES C1CC2CC1CC2n1c2cnccc2c2cnc(Nc3ccc(cc3)N3CCNCC3)nc12
Show InChI InChI=1S/C26H29N7/c1-2-18-13-17(1)14-23(18)33-24-16-28-8-7-21(24)22-15-29-26(31-25(22)33)30-19-3-5-20(6-4-19)32-11-9-27-10-12-32/h3-8,15-18,23,27H,1-2,9-14H2,(H,29,30,31)
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n/an/a 2.60n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132298
PNG
(US8841312, 41)
Show SMILES N#Cc1ccc2c(c1)n(C1CCCC1)c1nc(Nc3ccc(cn3)N3CCNCC3)ncc21
Show InChI InChI=1S/C25H26N8/c26-14-17-5-7-20-21-16-29-25(31-24(21)33(22(20)13-17)18-3-1-2-4-18)30-23-8-6-19(15-28-23)32-11-9-27-10-12-32/h5-8,13,15-16,18,27H,1-4,9-12H2,(H,28,29,30,31)
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n/an/a 7.20n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132299
PNG
(US8841312, 42)
Show SMILES COc1cc2c(cn1)n(C1CCCC1)c1nc(Nc3ccc(cn3)N3CCNCC3)ncc21
Show InChI InChI=1S/C24H28N8O/c1-33-22-12-18-19-14-28-24(29-21-7-6-17(13-26-21)31-10-8-25-9-11-31)30-23(19)32(20(18)15-27-22)16-4-2-3-5-16/h6-7,12-16,25H,2-5,8-11H2,1H3,(H,26,28,29,30)
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n/an/a 500n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132300
PNG
(US8841312, 43)
Show SMILES Oc1cc2c(cn1)n(C1CCCC1)c1nc(Nc3ccc(cn3)N3CCNCC3)ncc21
Show InChI InChI=1S/C23H26N8O/c32-21-11-17-18-13-27-23(28-20-6-5-16(12-25-20)30-9-7-24-8-10-30)29-22(18)31(19(17)14-26-21)15-3-1-2-4-15/h5-6,11-15,24H,1-4,7-10H2,(H,26,32)(H,25,27,28,29)
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n/an/a 218n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132301
PNG
(US8841312, 44)
Show SMILES OCC1(CCCC1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12
Show InChI InChI=1S/C24H28N8O/c33-16-24(6-1-2-7-24)32-20-15-26-8-5-18(20)19-14-28-23(30-22(19)32)29-21-4-3-17(13-27-21)31-11-9-25-10-12-31/h3-5,8,13-15,25,33H,1-2,6-7,9-12,16H2,(H,27,28,29,30)
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n/an/a 25n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
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