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Compile Data Set for Download or QSAR

Found 158 hits Enz. Inhib. hit(s) with Target = 'DNA Polymerase alpha'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
DNA Polymerase alpha


(Bos taurus (bovine))
BDBM21688
PNG
(1-cyclopropyl-7-[4-(4-{4-[(3-ethyl-4-methylphenyl)...)
Show SMILES CCc1cc(Nc2cc(=O)n(CCCCN3CCN(CC3C)c3c(F)cc4c(c3F)n(cc(C(O)=O)c4=O)C3CC3)c(=O)[nH]2)ccc1C
Show InChI InChI=1S/C35H40F2N6O5/c1-4-22-15-23(8-7-20(22)2)38-28-17-29(44)42(35(48)39-28)12-6-5-11-40-13-14-41(18-21(40)3)32-27(36)16-25-31(30(32)37)43(24-9-10-24)19-26(33(25)45)34(46)47/h7-8,15-17,19,21,24,38H,4-6,9-14,18H2,1-3H3,(H,39,48)(H,46,47)
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>4.82E+5>-19.7n/an/an/an/an/a7.537



Microbiotix



Assay Description
Reaction velocities were determined at each dGTP concentration and used to create double reciprocal plots of velocity versus dGTP concentration. The ...


Antimicrob Agents Chemother 51: 119-27 (2007)


Article DOI: 10.1128/AAC.01311-05
BindingDB Entry DOI: 10.7270/Q2988599
More data for this
Ligand-Target Pair
DNA Polymerase alpha


(Bos taurus (bovine))
BDBM21686
PNG
(3-(4-hydroxybutyl)-6-(3-ethyl-4-methylanilino)urac...)
Show SMILES CCc1cc(Nc2cc(=O)n(CCCCO)c(=O)[nH]2)ccc1C
Show InChI InChI=1S/C17H23N3O3/c1-3-13-10-14(7-6-12(13)2)18-15-11-16(22)20(17(23)19-15)8-4-5-9-21/h6-7,10-11,18,21H,3-5,8-9H2,1-2H3,(H,19,23)
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>1.01E+6>-17.8n/an/an/an/an/a7.537



Microbiotix



Assay Description
Reaction velocities were determined at each dGTP concentration and used to create double reciprocal plots of velocity versus dGTP concentration. The ...


Antimicrob Agents Chemother 51: 119-27 (2007)


Article DOI: 10.1128/AAC.01311-05
BindingDB Entry DOI: 10.7270/Q2988599
More data for this
Ligand-Target Pair
DNA Polymerase alpha


(Bos taurus (bovine))
BDBM33386
PNG
(dehydroaltenusin derivative, 14)
Show SMILES CCCOc1cc(O)c2C(=O)OC3(C)CC(=O)C(=O)C=C3c2c1
Show InChI InChI=1S/C17H16O6/c1-3-4-22-9-5-10-11-7-12(18)14(20)8-17(11,2)23-16(21)15(10)13(19)6-9/h5-7,19H,3-4,8H2,1-2H3
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n/an/a 180n/an/an/an/a7.537



Kyoto Prefectural University



Assay Description
For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...


Bioorg Med Chem 17: 7227-38 (2009)


Article DOI: 10.1016/j.bmc.2009.08.051
BindingDB Entry DOI: 10.7270/Q2348HQK
More data for this
Ligand-Target Pair
DNA Polymerase alpha


(Bos taurus (bovine))
BDBM33387
PNG
(dehydroaltenusin derivative, 15)
Show SMILES CCCCCCOc1cc(O)c2C(=O)OC3(C)CC(=O)C(=O)C=C3c2c1
Show InChI InChI=1S/C20H22O6/c1-3-4-5-6-7-25-12-8-13-14-10-15(21)17(23)11-20(14,2)26-19(24)18(13)16(22)9-12/h8-10,22H,3-7,11H2,1-2H3
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n/an/a 90n/an/an/an/a7.537



Kyoto Prefectural University



Assay Description
For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...


Bioorg Med Chem 17: 7227-38 (2009)


Article DOI: 10.1016/j.bmc.2009.08.051
BindingDB Entry DOI: 10.7270/Q2348HQK
More data for this
Ligand-Target Pair
DNA Polymerase alpha


(Bos taurus (bovine))
BDBM33388
PNG
(dehydroaltenusin derivative, 16)
Show SMILES CCCCCCCCCCCCOc1cc(O)c2C(=O)OC3(C)CC(=O)C(=O)C=C3c2c1
Show InChI InChI=1S/C26H34O6/c1-3-4-5-6-7-8-9-10-11-12-13-31-18-14-19-20-16-21(27)23(29)17-26(20,2)32-25(30)24(19)22(28)15-18/h14-16,28H,3-13,17H2,1-2H3
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n/an/a 60n/an/an/an/a7.537



Kyoto Prefectural University



Assay Description
For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...


Bioorg Med Chem 17: 7227-38 (2009)


Article DOI: 10.1016/j.bmc.2009.08.051
BindingDB Entry DOI: 10.7270/Q2348HQK
More data for this
Ligand-Target Pair
DNA Polymerase alpha


(Bos taurus (bovine))
BDBM33389
PNG
(dehydroaltenusin derivative, 20)
Show SMILES CC12CC(=O)C(=O)C=C1c1cccc(O)c1C(=O)O2
Show InChI InChI=1S/C14H10O5/c1-14-6-11(17)10(16)5-8(14)7-3-2-4-9(15)12(7)13(18)19-14/h2-5,15H,6H2,1H3
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n/an/a 240n/an/an/an/a7.537



Kyoto Prefectural University



Assay Description
For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...


Bioorg Med Chem 17: 7227-38 (2009)


Article DOI: 10.1016/j.bmc.2009.08.051
BindingDB Entry DOI: 10.7270/Q2348HQK
More data for this
Ligand-Target Pair
DNA Polymerase alpha


(Bos taurus (bovine))
BDBM33385
PNG
(desmethyldehydroaltenusin, 2)
Show SMILES CC12CC(=O)C(=O)C=C1c1cc(O)cc(O)c1C(=O)O2
Show InChI InChI=1S/C14H10O6/c1-14-5-11(18)9(16)4-8(14)7-2-6(15)3-10(17)12(7)13(19)20-14/h2-4,15,17H,5H2,1H3
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n/an/a 890n/an/an/an/a7.537



Kyoto Prefectural University



Assay Description
For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...


Bioorg Med Chem 17: 7227-38 (2009)


Article DOI: 10.1016/j.bmc.2009.08.051
BindingDB Entry DOI: 10.7270/Q2348HQK
More data for this
Ligand-Target Pair
DNA Polymerase alpha


(Bos taurus (bovine))
BDBM33384
PNG
(dehydroaltenusin)
Show SMILES COc1cc(O)c2C(=O)OC3(C)CC(=O)C(=O)C=C3c2c1
Show InChI InChI=1S/C15H12O6/c1-15-6-12(18)10(16)5-9(15)8-3-7(20-2)4-11(17)13(8)14(19)21-15/h3-5,17H,6H2,1-2H3
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n/an/a 680n/an/an/an/a7.537



Kyoto Prefectural University



Assay Description
For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...


Bioorg Med Chem 17: 7227-38 (2009)


Article DOI: 10.1016/j.bmc.2009.08.051
BindingDB Entry DOI: 10.7270/Q2348HQK
More data for this
Ligand-Target Pair
DNA Polymerase alpha


(Bos taurus (bovine))
BDBM33390
PNG
(dehydroaltenusin derivative, 25)
Show SMILES COc1cc(O)c2c(c1)c1cc(OCc3ccccc3)c(OCc3ccccc3)cc1oc2=O
Show InChI InChI=1S/C28H22O6/c1-31-20-12-22-21-14-25(32-16-18-8-4-2-5-9-18)26(33-17-19-10-6-3-7-11-19)15-24(21)34-28(30)27(22)23(29)13-20/h2-15,29H,16-17H2,1H3
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n/an/a>2.00E+5n/an/an/an/a7.537



Kyoto Prefectural University



Assay Description
For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...


Bioorg Med Chem 17: 7227-38 (2009)


Article DOI: 10.1016/j.bmc.2009.08.051
BindingDB Entry DOI: 10.7270/Q2348HQK
More data for this
Ligand-Target Pair
DNA Polymerase alpha


(Bos taurus (bovine))
BDBM33393
PNG
(dehydroaltenusin derivative, 32)
Show SMILES CC12OC(=O)c3c(O)cccc3C1=CC(=O)C=C2
Show InChI InChI=1S/C14H10O4/c1-14-6-5-8(15)7-10(14)9-3-2-4-11(16)12(9)13(17)18-14/h2-7,16H,1H3
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n/an/a>2.00E+5n/an/an/an/a7.537



Kyoto Prefectural University



Assay Description
For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...


Bioorg Med Chem 17: 7227-38 (2009)


Article DOI: 10.1016/j.bmc.2009.08.051
BindingDB Entry DOI: 10.7270/Q2348HQK
More data for this
Ligand-Target Pair
DNA Polymerase alpha


(Bos taurus (bovine))
BDBM33392
PNG
(dehydroaltenusin derivative, 31)
Show SMILES COc1cc(O)c2C(=O)OC3(C)C=CC(=O)C=C3c2c1
Show InChI InChI=1S/C15H12O5/c1-15-4-3-8(16)5-11(15)10-6-9(19-2)7-12(17)13(10)14(18)20-15/h3-7,17H,1-2H3
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n/an/a>2.00E+5n/an/an/an/a7.537



Kyoto Prefectural University



Assay Description
For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...


Bioorg Med Chem 17: 7227-38 (2009)


Article DOI: 10.1016/j.bmc.2009.08.051
BindingDB Entry DOI: 10.7270/Q2348HQK
More data for this
Ligand-Target Pair
DNA Polymerase alpha


(Bos taurus (bovine))
BDBM33391
PNG
(dehydroaltenusin derivative, 26)
Show SMILES COc1cc(O)c2c(c1)c1cc(O)c(O)cc1oc2=O
Show InChI InChI=1S/C14H10O6/c1-19-6-2-8-7-4-9(15)10(16)5-12(7)20-14(18)13(8)11(17)3-6/h2-5,15-17H,1H3
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n/an/a>2.00E+5n/an/an/an/a7.537



Kyoto Prefectural University



Assay Description
For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...


Bioorg Med Chem 17: 7227-38 (2009)


Article DOI: 10.1016/j.bmc.2009.08.051
BindingDB Entry DOI: 10.7270/Q2348HQK
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens)
BDBM50225280
PNG
(CHEMBL3144215)
Show SMILES CCCCc1ccc(NC2=NC(=O)C3N=CN([C@H]4C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O4)C3=N2)cc1
Show InChI InChI=1S/C20H28N5O13P3/c1-2-3-4-12-5-7-13(8-6-12)22-20-23-18-17(19(27)24-20)21-11-25(18)16-9-14(26)15(36-16)10-35-40(31,32)38-41(33,34)37-39(28,29)30/h5-8,11,14-17,26H,2-4,9-10H2,1H3,(H,31,32)(H,33,34)(H,22,24,27)(H2,28,29,30)/t14-,15+,16+,17?/m0/s1
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1n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for its inhibitory activity against HeLa DNA polymerase alpha, Ki values were obtained in the absence of dGTP


J Med Chem 27: 175-81 (1984)


Article DOI: 10.1021/jm00368a012
BindingDB Entry DOI: 10.7270/Q2HH6KMT
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens)
BDBM50293303
PNG
(CHEMBL498103 | gallic acid 5,6-dihydroxy-3-carboxy...)
Show SMILES OC(=O)c1cc(O)c(O)c(OC(=O)c2ccc(O)c(O)c2O)c1
Show InChI InChI=1S/C14H10O9/c15-7-2-1-6(10(17)12(7)19)14(22)23-9-4-5(13(20)21)3-8(16)11(9)18/h1-4,15-19H,(H,20,21)
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830n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of DNA polymerase alpha from human KB3 cells


J Nat Prod 53: 1234-1240 (1990)


Article DOI: 10.1021/np50071a015
BindingDB Entry DOI: 10.7270/Q27P8ZC7
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens)
BDBM50025592
PNG
((4-Butyl-phenyl)-(6-methylsulfanyl-9H-purin-2-yl)-...)
Show SMILES CCCCc1ccc(Nc2nc(SC)c3[nH]cnc3n2)cc1
Show InChI InChI=1S/C16H19N5S/c1-3-4-5-11-6-8-12(9-7-11)19-16-20-14-13(17-10-18-14)15(21-16)22-2/h6-10H,3-5H2,1-2H3,(H2,17,18,19,20,21)
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1.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the concentration which gives half-maximal inhibition of Chinese Hamster Ovary DNA polymerase alpha


J Med Chem 30: 109-16 (1987)


Article DOI: 10.1021/jm00384a019
BindingDB Entry DOI: 10.7270/Q2ZG6R83
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens)
BDBM50025600
PNG
((4-Butyl-phenyl)-(6-methoxy-9H-purin-2-yl)-amine |...)
Show SMILES CCCCc1ccc(Nc2nc(OC)c3[nH]cnc3n2)cc1
Show InChI InChI=1S/C16H19N5O/c1-3-4-5-11-6-8-12(9-7-11)19-16-20-14-13(17-10-18-14)15(21-16)22-2/h6-10H,3-5H2,1-2H3,(H2,17,18,19,20,21)
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1.40E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the concentration which gives half-maximal inhibition of Chinese Hamster Ovary DNA polymerase alpha


J Med Chem 30: 109-16 (1987)


Article DOI: 10.1021/jm00384a019
BindingDB Entry DOI: 10.7270/Q2ZG6R83
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens)
BDBM50405103
PNG
(CHEMBL2115349)
Show SMILES CCCCc1ccc(Nc2nc3n(cnc3c(=O)[nH]2)[C@H]2C[C@H](O)[C@@H](CO)O2)cc1
Show InChI InChI=1S/C20H25N5O4/c1-2-3-4-12-5-7-13(8-6-12)22-20-23-18-17(19(28)24-20)21-11-25(18)16-9-14(27)15(10-26)29-16/h5-8,11,14-16,26-27H,2-4,9-10H2,1H3,(H2,22,23,24,28)/t14-,15+,16+/m0/s1
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2.30E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for its inhibitory activity against HeLa DNA polymerase alpha, Ki values were obtained in the absence of dGTP


J Med Chem 27: 175-81 (1984)


Article DOI: 10.1021/jm00368a012
BindingDB Entry DOI: 10.7270/Q2HH6KMT
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens)
BDBM50025598
PNG
((4-Butyl-phenyl)-(6-chloro-9H-purin-2-yl)-amine | ...)
Show SMILES CCCCc1ccc(Nc2nc(Cl)c3[nH]cnc3n2)cc1
Show InChI InChI=1S/C15H16ClN5/c1-2-3-4-10-5-7-11(8-6-10)19-15-20-13(16)12-14(21-15)18-9-17-12/h5-9H,2-4H2,1H3,(H2,17,18,19,20,21)
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2.60E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the concentration which gives half-maximal inhibition of Chinese Hamster Ovary DNA polymerase alpha


J Med Chem 30: 109-16 (1987)


Article DOI: 10.1021/jm00384a019
BindingDB Entry DOI: 10.7270/Q2ZG6R83
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens)
BDBM50153106
PNG
(CHEMBL189703 | [(3S,10R,13R,17R)-17-((R)-1,5-Dimet...)
Show SMILES CC(C)CCC[C@@H](C)[C@H]1CCC2C3CC=C4C[C@H](CC[C@]4(C)C3CC[C@]12C)OCC(O)=O
Show InChI InChI=1S/C29H48O3/c1-19(2)7-6-8-20(3)24-11-12-25-23-10-9-21-17-22(32-18-27(30)31)13-15-28(21,4)26(23)14-16-29(24,25)5/h9,19-20,22-26H,6-8,10-18H2,1-5H3,(H,30,31)/t20-,22+,23?,24-,25?,26?,28+,29-/m1/s1
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3.75E+3n/an/an/an/an/an/an/an/a



Frontier Research Center for Genome & Drug Discovery

Curated by ChEMBL


Assay Description
Inhibition constant against DNA polymerase alpha non competitively on dNTP substrate


J Med Chem 47: 4971-4 (2004)


Article DOI: 10.1021/jm030553v
BindingDB Entry DOI: 10.7270/Q2RN37BH
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens)
BDBM50025597
PNG
((4-Butyl-phenyl)-(9H-purin-2-yl)-amine | CHEMBL278...)
Show SMILES CCCCc1ccc(Nc2ncc3[nH]cnc3n2)cc1
Show InChI InChI=1S/C15H17N5/c1-2-3-4-11-5-7-12(8-6-11)19-15-16-9-13-14(20-15)18-10-17-13/h5-10H,2-4H2,1H3,(H2,16,17,18,19,20)
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5.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the concentration which gives half-maximal inhibition of Chinese Hamster Ovary DNA polymerase alpha


J Med Chem 30: 109-16 (1987)


Article DOI: 10.1021/jm00384a019
BindingDB Entry DOI: 10.7270/Q2ZG6R83
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens)
BDBM50013074
PNG
(2-(4-Butyl-phenylamino)-1,9-dihydro-purin-6-one | ...)
Show SMILES CCCCc1ccc(Nc2nc3nc[nH]c3c(=O)[nH]2)cc1
Show InChI InChI=1S/C15H17N5O/c1-2-3-4-10-5-7-11(8-6-10)18-15-19-13-12(14(21)20-15)16-9-17-13/h5-9H,2-4H2,1H3,(H3,16,17,18,19,20,21)
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7.50E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for its inhibitory activity against HeLa DNA polymerase alpha, Ki values were obtained in the absence of dGTP


J Med Chem 27: 175-81 (1984)


Article DOI: 10.1021/jm00368a012
BindingDB Entry DOI: 10.7270/Q2HH6KMT
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens)
BDBM50153111
PNG
(CHEMBL189667 | [(3S,5S,10S,13R,17R)-17-((R)-1,5-Di...)
Show SMILES CC(C)CCC[C@@H](C)[C@H]1CCC2C3CC[C@H]4C[C@H](CC[C@]4(C)C3CC[C@]12C)OCC(O)=O
Show InChI InChI=1S/C29H50O3/c1-19(2)7-6-8-20(3)24-11-12-25-23-10-9-21-17-22(32-18-27(30)31)13-15-28(21,4)26(23)14-16-29(24,25)5/h19-26H,6-18H2,1-5H3,(H,30,31)/t20-,21+,22+,23?,24-,25?,26?,28+,29-/m1/s1
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7.84E+3n/an/an/an/an/an/an/an/a



Frontier Research Center for Genome & Drug Discovery

Curated by ChEMBL


Assay Description
Inhibition constant against DNA polymerase alpha non competitively on dNTP substrate


J Med Chem 47: 4971-4 (2004)


Article DOI: 10.1021/jm030553v
BindingDB Entry DOI: 10.7270/Q2RN37BH
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens)
BDBM50153113
PNG
(CHEMBL364611 | [(3S,10R,13R,17R)-17-((E)-(1R,4S)-4...)
Show SMILES CC[C@H](\C=C\[C@@H](C)[C@H]1CCC2C3CC=C4C[C@H](CC[C@]4(C)C3CC[C@]12C)OCC(O)=O)C(C)C
Show InChI InChI=1S/C31H50O3/c1-7-22(20(2)3)9-8-21(4)26-12-13-27-25-11-10-23-18-24(34-19-29(32)33)14-16-30(23,5)28(25)15-17-31(26,27)6/h8-10,20-22,24-28H,7,11-19H2,1-6H3,(H,32,33)/b9-8+/t21-,22-,24+,25?,26-,27?,28?,30+,31-/m1/s1
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1.12E+4n/an/an/an/an/an/an/an/a



Frontier Research Center for Genome & Drug Discovery

Curated by ChEMBL


Assay Description
Inhibition constant against DNA polymerase alpha non competitively on dNTP substrate


J Med Chem 47: 4971-4 (2004)


Article DOI: 10.1021/jm030553v
BindingDB Entry DOI: 10.7270/Q2RN37BH
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens)
BDBM50013074
PNG
(2-(4-Butyl-phenylamino)-1,9-dihydro-purin-6-one | ...)
Show SMILES CCCCc1ccc(Nc2nc3nc[nH]c3c(=O)[nH]2)cc1
Show InChI InChI=1S/C15H17N5O/c1-2-3-4-10-5-7-11(8-6-10)18-15-19-13-12(14(21)20-15)16-9-17-13/h5-9H,2-4H2,1H3,(H3,16,17,18,19,20,21)
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1.20E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the concentration which gives half-maximal inhibition of Chinese Hamster Ovary DNA polymerase alpha


J Med Chem 30: 109-16 (1987)


Article DOI: 10.1021/jm00384a019
BindingDB Entry DOI: 10.7270/Q2ZG6R83
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens)
BDBM50153111
PNG
(CHEMBL189667 | [(3S,5S,10S,13R,17R)-17-((R)-1,5-Di...)
Show SMILES CC(C)CCC[C@@H](C)[C@H]1CCC2C3CC[C@H]4C[C@H](CC[C@]4(C)C3CC[C@]12C)OCC(O)=O
Show InChI InChI=1S/C29H50O3/c1-19(2)7-6-8-20(3)24-11-12-25-23-10-9-21-17-22(32-18-27(30)31)13-15-28(21,4)26(23)14-16-29(24,25)5/h19-26H,6-18H2,1-5H3,(H,30,31)/t20-,21+,22+,23?,24-,25?,26?,28+,29-/m1/s1
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1.38E+4n/an/an/an/an/an/an/an/a



Frontier Research Center for Genome & Drug Discovery

Curated by ChEMBL


Assay Description
Inhibition constant against DNA polymerase alpha competitively on DNA template


J Med Chem 47: 4971-4 (2004)


Article DOI: 10.1021/jm030553v
BindingDB Entry DOI: 10.7270/Q2RN37BH
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens)
BDBM50025593
PNG
(CHEMBL16122 | N*2*-(4-Butyl-phenyl)-9H-purine-2,6-...)
Show SMILES CCCCc1ccc(Nc2nc(N)c3[nH]cnc3n2)cc1
Show InChI InChI=1S/C15H18N6/c1-2-3-4-10-5-7-11(8-6-10)19-15-20-13(16)12-14(21-15)18-9-17-12/h5-9H,2-4H2,1H3,(H4,16,17,18,19,20,21)
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1.44E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the concentration which gives half-maximal inhibition of Chinese Hamster Ovary DNA polymerase alpha


J Med Chem 30: 109-16 (1987)


Article DOI: 10.1021/jm00384a019
BindingDB Entry DOI: 10.7270/Q2ZG6R83
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens)
BDBM50153106
PNG
(CHEMBL189703 | [(3S,10R,13R,17R)-17-((R)-1,5-Dimet...)
Show SMILES CC(C)CCC[C@@H](C)[C@H]1CCC2C3CC=C4C[C@H](CC[C@]4(C)C3CC[C@]12C)OCC(O)=O
Show InChI InChI=1S/C29H48O3/c1-19(2)7-6-8-20(3)24-11-12-25-23-10-9-21-17-22(32-18-27(30)31)13-15-28(21,4)26(23)14-16-29(24,25)5/h9,19-20,22-26H,6-8,10-18H2,1-5H3,(H,30,31)/t20-,22+,23?,24-,25?,26?,28+,29-/m1/s1
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1.85E+4n/an/an/an/an/an/an/an/a



Frontier Research Center for Genome & Drug Discovery

Curated by ChEMBL


Assay Description
Inhibition constant against DNA polymerase alpha competitively on DNA template


J Med Chem 47: 4971-4 (2004)


Article DOI: 10.1021/jm030553v
BindingDB Entry DOI: 10.7270/Q2RN37BH
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens)
BDBM50405103
PNG
(CHEMBL2115349)
Show SMILES CCCCc1ccc(Nc2nc3n(cnc3c(=O)[nH]2)[C@H]2C[C@H](O)[C@@H](CO)O2)cc1
Show InChI InChI=1S/C20H25N5O4/c1-2-3-4-12-5-7-13(8-6-12)22-20-23-18-17(19(28)24-20)21-11-25(18)16-9-14(27)15(10-26)29-16/h5-8,11,14-16,26-27H,2-4,9-10H2,1H3,(H2,22,23,24,28)/t14-,15+,16+/m0/s1
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2.20E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for its inhibitory activity against HeLa DNA polymerase alpha, Ki values were obtained in the absence of dGTP


J Med Chem 27: 175-81 (1984)


Article DOI: 10.1021/jm00368a012
BindingDB Entry DOI: 10.7270/Q2HH6KMT
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens)
BDBM50153113
PNG
(CHEMBL364611 | [(3S,10R,13R,17R)-17-((E)-(1R,4S)-4...)
Show SMILES CC[C@H](\C=C\[C@@H](C)[C@H]1CCC2C3CC=C4C[C@H](CC[C@]4(C)C3CC[C@]12C)OCC(O)=O)C(C)C
Show InChI InChI=1S/C31H50O3/c1-7-22(20(2)3)9-8-21(4)26-12-13-27-25-11-10-23-18-24(34-19-29(32)33)14-16-30(23,5)28(25)15-17-31(26,27)6/h8-10,20-22,24-28H,7,11-19H2,1-6H3,(H,32,33)/b9-8+/t21-,22-,24+,25?,26-,27?,28?,30+,31-/m1/s1
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2.79E+4n/an/an/an/an/an/an/an/a



Frontier Research Center for Genome & Drug Discovery

Curated by ChEMBL


Assay Description
Inhibition constant against DNA polymerase alpha competitively on DNA template


J Med Chem 47: 4971-4 (2004)


Article DOI: 10.1021/jm030553v
BindingDB Entry DOI: 10.7270/Q2RN37BH
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens)
BDBM50025595
PNG
(2-(4-Butyl-phenylamino)-1,9-dihydro-purine-6-thion...)
Show SMILES CCCCc1ccc(Nc2nc3nc[nH]c3c(=S)[nH]2)cc1
Show InChI InChI=1S/C15H17N5S/c1-2-3-4-10-5-7-11(8-6-10)18-15-19-13-12(14(21)20-15)16-9-17-13/h5-9H,2-4H2,1H3,(H3,16,17,18,19,20,21)
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3.60E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the concentration which gives half-maximal inhibition of Chinese Hamster Ovary DNA polymerase alpha


J Med Chem 30: 109-16 (1987)


Article DOI: 10.1021/jm00384a019
BindingDB Entry DOI: 10.7270/Q2ZG6R83
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens)
BDBM50405103
PNG
(CHEMBL2115349)
Show SMILES CCCCc1ccc(Nc2nc3n(cnc3c(=O)[nH]2)[C@H]2C[C@H](O)[C@@H](CO)O2)cc1
Show InChI InChI=1S/C20H25N5O4/c1-2-3-4-12-5-7-13(8-6-12)22-20-23-18-17(19(28)24-20)21-11-25(18)16-9-14(27)15(10-26)29-16/h5-8,11,14-16,26-27H,2-4,9-10H2,1H3,(H2,22,23,24,28)/t14-,15+,16+/m0/s1
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3.70E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for its inhibitory activity against HeLa DNA polymerase alpha, Ki values were obtained in the absence of dGTP


J Med Chem 27: 175-81 (1984)


Article DOI: 10.1021/jm00368a012
BindingDB Entry DOI: 10.7270/Q2HH6KMT
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens)
BDBM50013075
PNG
(2-(Indan-5-ylamino)-1,9-dihydro-purin-6-one | CHEM...)
Show SMILES O=c1[nH]c(Nc2ccc3CCCc3c2)nc2nc[nH]c12
Show InChI InChI=1S/C14H13N5O/c20-13-11-12(16-7-15-11)18-14(19-13)17-10-5-4-8-2-1-3-9(8)6-10/h4-7H,1-3H2,(H3,15,16,17,18,19,20)
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4.40E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the concentration which gives half-maximal inhibition of Chinese Hamster Ovary DNA polymerase alpha


J Med Chem 30: 109-16 (1987)


Article DOI: 10.1021/jm00384a019
BindingDB Entry DOI: 10.7270/Q2ZG6R83
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens)
BDBM50118823
PNG
(2,2-Dimethyl-propionic acid [5-(7-amino-[1,2,3]tri...)
Show SMILES CC(C)(C)C(=O)OCOP(=O)(OCOC(=O)C(C)(C)C)OC[C@H]1OC(C[C@H]1O)n1nnc2c(N)ncnc12
Show InChI InChI=1S/C21H33N6O10P/c1-20(2,3)18(29)32-10-35-38(31,36-11-33-19(30)21(4,5)6)34-8-13-12(28)7-14(37-13)27-17-15(25-26-27)16(22)23-9-24-17/h9,12-14,28H,7-8,10-11H2,1-6H3,(H2,22,23,24)/t12-,13-,14?/m1/s1
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1.56E+5n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit the incorporation of dATP into DNA by DNA polymerase alpha


J Med Chem 45: 4505-12 (2002)


Article DOI: 10.1021/jm020107s
BindingDB Entry DOI: 10.7270/Q2KS6QWF
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens)
BDBM50118822
PNG
(2,2-Dimethyl-propionic acid [5-(6-amino-8-bromo-pu...)
Show SMILES CC(C)(C)C(=O)OCOP(=O)(OCOC(=O)C(C)(C)C)OC[C@H]1O[C@H](C[C@@H]1O)n1c(Br)nc2c(N)ncnc12
Show InChI InChI=1S/C22H33BrN5O10P/c1-21(2,3)18(30)33-10-36-39(32,37-11-34-19(31)22(4,5)6)35-8-13-12(29)7-14(38-13)28-17-15(27-20(28)23)16(24)25-9-26-17/h9,12-14,29H,7-8,10-11H2,1-6H3,(H2,24,25,26)/t12-,13+,14+/m0/s1
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5.48E+5n/an/an/an/an/an/an/an/a



Southern Research Institute

Curated by ChEMBL


Assay Description
Ability to inhibit the incorporation of dATP into DNA by DNA polymerase alpha


J Med Chem 45: 4505-12 (2002)


Article DOI: 10.1021/jm020107s
BindingDB Entry DOI: 10.7270/Q2KS6QWF
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens)
BDBM50013093
PNG
(2-(3-Ethyl-4-methyl-phenylamino)-1,9-dihydro-purin...)
Show SMILES CCc1cc(Nc2nc3nc[nH]c3c(=O)[nH]2)ccc1C
Show InChI InChI=1S/C14H15N5O/c1-3-9-6-10(5-4-8(9)2)17-14-18-12-11(13(20)19-14)15-7-16-12/h4-7H,3H2,1-2H3,(H3,15,16,17,18,19,20)
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1.76E+6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the concentration which gives half-maximal inhibition of Chinese Hamster Ovary DNA polymerase alpha


J Med Chem 30: 109-16 (1987)


Article DOI: 10.1021/jm00384a019
BindingDB Entry DOI: 10.7270/Q2ZG6R83
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens)
BDBM50034961
PNG
(6-Chloro-N*4*-(3,4-dichloro-phenyl)-pyrimidine-2,4...)
Show SMILES Nc1nc(Cl)cc(Nc2ccc(Cl)c(Cl)c2)n1
Show InChI InChI=1S/C10H7Cl3N4/c11-6-2-1-5(3-7(6)12)15-9-4-8(13)16-10(14)17-9/h1-4H,(H3,14,15,16,17)
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n/an/a>1.00E+6n/an/an/an/an/an/a



Stanford University Medical School

Curated by ChEMBL


Assay Description
Inhibition against DNA polymerase by direct assay with activated DNA and 25 uM dNTPs lacking the expected competitor substrate


J Med Chem 38: 1820-5 (1995)


Article DOI: 10.1021/jm00010a027
BindingDB Entry DOI: 10.7270/Q29K4983
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens)
BDBM50013091
PNG
(2-(3,4-Dichloro-phenylamino)-1,9-dihydro-purin-6-o...)
Show SMILES Clc1ccc(Nc2nc3nc[nH]c3c(=O)[nH]2)cc1Cl
Show InChI InChI=1S/C11H7Cl2N5O/c12-6-2-1-5(3-7(6)13)16-11-17-9-8(10(19)18-11)14-4-15-9/h1-4H,(H3,14,15,16,17,18,19)
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n/an/a 4.60E+4n/an/an/an/an/an/a



Stanford University Medical School

Curated by ChEMBL


Assay Description
Inhibition against DNA polymerase by direct assay with activated DNA and 25 uM dNTPs lacking the expected competitor substrate


J Med Chem 38: 1820-5 (1995)


Article DOI: 10.1021/jm00010a027
BindingDB Entry DOI: 10.7270/Q29K4983
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens)
BDBM50034955
PNG
(CHEMBL53605 | N*2*-(3,4-Dichloro-phenyl)-9H-purine...)
Show SMILES Nc1nc(Nc2ccc(Cl)c(Cl)c2)nc2nc[nH]c12
Show InChI InChI=1S/C11H8Cl2N6/c12-6-2-1-5(3-7(6)13)17-11-18-9(14)8-10(19-11)16-4-15-8/h1-4H,(H4,14,15,16,17,18,19)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Stanford University Medical School

Curated by ChEMBL


Assay Description
Inhibition against coupled primase-DNA polymerase I assay


J Med Chem 38: 1820-5 (1995)


Article DOI: 10.1021/jm00010a027
BindingDB Entry DOI: 10.7270/Q29K4983
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens)
BDBM50205415
PNG
(({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-methyl-2,4-...)
Show SMILES Cc1cn([C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c(=O)[nH]c1=O
Show InChI InChI=1S/C10H17N2O15P3/c1-4-2-12(10(16)11-8(4)15)9-7(14)6(13)5(25-9)3-24-29(20,21)27-30(22,23)26-28(17,18)19/h2,5-7,9,13-14H,3H2,1H3,(H,20,21)(H,22,23)(H,11,15,16)(H2,17,18,19)/t5-,6-,7-,9-/m1/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL


Assay Description
Compound was evaluated for 50% inhibition of DHBV DNA polymerase (duck hepatitis B virus)


J Med Chem 41: 2040-6 (1998)


Article DOI: 10.1021/jm9704210
BindingDB Entry DOI: 10.7270/Q2FT8MQT
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens)
BDBM50408425
PNG
(CHEMBL2092835)
Show SMILES Nc1ccn([C@@H]2C[C@@H](F)[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)c(=O)n1
Show InChI InChI=1S/C9H15FN3O12P3/c10-5-3-8(13-2-1-7(11)12-9(13)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8H,3-4H2,(H,18,19)(H,20,21)(H2,11,12,14)(H2,15,16,17)/t5-,6+,8+/m1/s1
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n/an/a 1.04E+4n/an/an/an/an/an/a



Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL


Assay Description
Compound was evaluated for 50% inhibition of DHBV DNA polymerase (duck hepatitis B virus)


J Med Chem 41: 2040-6 (1998)


Article DOI: 10.1021/jm9704210
BindingDB Entry DOI: 10.7270/Q2FT8MQT
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens)
BDBM50408428
PNG
(CHEMBL2092834)
Show SMILES OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@@H]1O[C@@H](C[C@H]1F)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C9H14FN2O13P3/c10-5-3-8(12-2-1-7(13)11-9(12)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8H,3-4H2,(H,18,19)(H,20,21)(H,11,13,14)(H2,15,16,17)/t5-,6+,8+/m1/s1
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n/an/a>4.00E+4n/an/an/an/an/an/a



Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL


Assay Description
Compound was evaluated for 50% inhibition of DHBV DNA polymerase (duck hepatitis B virus)


J Med Chem 41: 2040-6 (1998)


Article DOI: 10.1021/jm9704210
BindingDB Entry DOI: 10.7270/Q2FT8MQT
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens)
BDBM50408425
PNG
(CHEMBL2092835)
Show SMILES Nc1ccn([C@@H]2C[C@@H](F)[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)c(=O)n1
Show InChI InChI=1S/C9H15FN3O12P3/c10-5-3-8(13-2-1-7(11)12-9(13)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8H,3-4H2,(H,18,19)(H,20,21)(H2,11,12,14)(H2,15,16,17)/t5-,6+,8+/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of cellular DNA polymerase (alpha)


J Med Chem 41: 2040-6 (1998)


Article DOI: 10.1021/jm9704210
BindingDB Entry DOI: 10.7270/Q2FT8MQT
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens)
BDBM50408428
PNG
(CHEMBL2092834)
Show SMILES OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@@H]1O[C@@H](C[C@H]1F)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C9H14FN2O13P3/c10-5-3-8(12-2-1-7(13)11-9(12)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8H,3-4H2,(H,18,19)(H,20,21)(H,11,13,14)(H2,15,16,17)/t5-,6+,8+/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of cellular DNA polymerase (alpha)


J Med Chem 41: 2040-6 (1998)


Article DOI: 10.1021/jm9704210
BindingDB Entry DOI: 10.7270/Q2FT8MQT
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens)
BDBM50408426
PNG
(CHEMBL2092833)
Show SMILES Cc1cn([C@@H]2C[C@@H](F)[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C10H16FN2O13P3/c1-5-3-13(10(15)12-9(5)14)8-2-6(11)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8H,2,4H2,1H3,(H,19,20)(H,21,22)(H,12,14,15)(H2,16,17,18)/t6-,7+,8+/m1/s1
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n/an/a>2.00E+5n/an/an/an/an/an/a



Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of cellular DNA polymerase (alpha)


J Med Chem 41: 2040-6 (1998)


Article DOI: 10.1021/jm9704210
BindingDB Entry DOI: 10.7270/Q2FT8MQT
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens)
BDBM50408427
PNG
(CHEMBL483492)
Show SMILES Cc1cn([C@@H]2C[C@@H](F)[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)c(=O)nc1N
Show InChI InChI=1S/C10H17FN3O12P3/c1-5-3-14(10(15)13-9(5)12)8-2-6(11)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8H,2,4H2,1H3,(H,19,20)(H,21,22)(H2,12,13,15)(H2,16,17,18)/t6-,7+,8+/m1/s1
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n/an/a>2.00E+5n/an/an/an/an/an/a



Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of cellular DNA polymerase (alpha)


J Med Chem 41: 2040-6 (1998)


Article DOI: 10.1021/jm9704210
BindingDB Entry DOI: 10.7270/Q2FT8MQT
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens)
BDBM50408426
PNG
(CHEMBL2092833)
Show SMILES Cc1cn([C@@H]2C[C@@H](F)[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C10H16FN2O13P3/c1-5-3-13(10(15)12-9(5)14)8-2-6(11)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8H,2,4H2,1H3,(H,19,20)(H,21,22)(H,12,14,15)(H2,16,17,18)/t6-,7+,8+/m1/s1
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n/an/a 170n/an/an/an/an/an/a



Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL


Assay Description
Compound was evaluated for 50% inhibition of DHBV DNA polymerase (duck hepatitis B virus)


J Med Chem 41: 2040-6 (1998)


Article DOI: 10.1021/jm9704210
BindingDB Entry DOI: 10.7270/Q2FT8MQT
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens)
BDBM50408427
PNG
(CHEMBL483492)
Show SMILES Cc1cn([C@@H]2C[C@@H](F)[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)c(=O)nc1N
Show InChI InChI=1S/C10H17FN3O12P3/c1-5-3-14(10(15)13-9(5)12)8-2-6(11)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8H,2,4H2,1H3,(H,19,20)(H,21,22)(H2,12,13,15)(H2,16,17,18)/t6-,7+,8+/m1/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL


Assay Description
Compound was evaluated for 50% inhibition of DHBV DNA polymerase (duck hepatitis B virus)


J Med Chem 41: 2040-6 (1998)


Article DOI: 10.1021/jm9704210
BindingDB Entry DOI: 10.7270/Q2FT8MQT
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens)
BDBM50034955
PNG
(CHEMBL53605 | N*2*-(3,4-Dichloro-phenyl)-9H-purine...)
Show SMILES Nc1nc(Nc2ccc(Cl)c(Cl)c2)nc2nc[nH]c12
Show InChI InChI=1S/C11H8Cl2N6/c12-6-2-1-5(3-7(6)13)17-11-18-9(14)8-10(19-11)16-4-15-8/h1-4H,(H4,14,15,16,17,18,19)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Stanford University Medical School

Curated by ChEMBL


Assay Description
Inhibition against coupled primase-DNA polymerase I assay


J Med Chem 38: 1820-5 (1995)


Article DOI: 10.1021/jm00010a027
BindingDB Entry DOI: 10.7270/Q29K4983
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens)
BDBM50034961
PNG
(6-Chloro-N*4*-(3,4-dichloro-phenyl)-pyrimidine-2,4...)
Show SMILES Nc1nc(Cl)cc(Nc2ccc(Cl)c(Cl)c2)n1
Show InChI InChI=1S/C10H7Cl3N4/c11-6-2-1-5(3-7(6)12)15-9-4-8(13)16-10(14)17-9/h1-4H,(H3,14,15,16,17)
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n/an/a>1.00E+6n/an/an/an/an/an/a



Stanford University Medical School

Curated by ChEMBL


Assay Description
Inhibition against DNA polymerase by direct assay with activated DNA and 25 uM dNTPs lacking the expected competitor substrate


J Med Chem 38: 1820-5 (1995)


Article DOI: 10.1021/jm00010a027
BindingDB Entry DOI: 10.7270/Q29K4983
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens)
BDBM50013091
PNG
(2-(3,4-Dichloro-phenylamino)-1,9-dihydro-purin-6-o...)
Show SMILES Clc1ccc(Nc2nc3nc[nH]c3c(=O)[nH]2)cc1Cl
Show InChI InChI=1S/C11H7Cl2N5O/c12-6-2-1-5(3-7(6)13)16-11-17-9-8(10(19)18-11)14-4-15-9/h1-4H,(H3,14,15,16,17,18,19)
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n/an/a 4.60E+4n/an/an/an/an/an/a



Stanford University Medical School

Curated by ChEMBL


Assay Description
Inhibition against DNA polymerase by direct assay with activated DNA and 25 uM dNTPs lacking the expected competitor substrate


J Med Chem 38: 1820-5 (1995)


Article DOI: 10.1021/jm00010a027
BindingDB Entry DOI: 10.7270/Q29K4983
More data for this
Ligand-Target Pair
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