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Compile Data Set for Download or QSAR

Found 391 hits Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 2'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM27950
PNG
(2-[4-(4-{4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1...)
Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)C12CCC(CC(O)=O)(CC1)CC2
Show InChI InChI=1S/C24H28N4O3/c1-22(2)19(28-18-20(25)26-14-27-21(18)31-22)15-3-5-16(6-4-15)24-10-7-23(8-11-24,9-12-24)13-17(29)30/h3-6,14H,7-13H2,1-2H3,(H,29,30)(H2,25,26,27)
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Article
PubMed
n/an/an/an/an/an/an/a7.422



AstraZeneca



Assay Description
The assay mixture contains test compound, membrane protein, and 1,2 dioleoyl-sn-glycerol in a 96-deep well plate. The reaction was started by adding ...


J Med Chem 52: 1558-68 (2009)


Article DOI: 10.1021/jm801507v
BindingDB Entry DOI: 10.7270/Q2N014VR
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM27947
PNG
(2-[4-(4-{4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1...)
Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1
Show InChI InChI=1S/C22H26N4O3/c1-22(2)19(26-18-20(23)24-12-25-21(18)29-22)16-9-7-15(8-10-16)14-5-3-13(4-6-14)11-17(27)28/h7-10,12-14H,3-6,11H2,1-2H3,(H,27,28)(H2,23,24,25)/t13-,14-
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n/an/an/an/an/an/an/a7.422



AstraZeneca



Assay Description
The assay mixture contains test compound, membrane protein, and 1,2 dioleoyl-sn-glycerol in a 96-deep well plate. The reaction was started by adding ...


J Med Chem 52: 1558-68 (2009)


Article DOI: 10.1021/jm801507v
BindingDB Entry DOI: 10.7270/Q2N014VR
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215446
PNG
(US9296745, 1)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1S/C23H24F3N5O2/c24-23(25,26)33-17-7-3-5-15(13-17)20-27-18-8-9-19(28-21(18)29-20)31-12-4-6-16(14-31)22(32)30-10-1-2-11-30/h3,5,7-9,13,16H,1-2,4,6,10-12,14H2,(H,27,28,29)/t16-/m1/s1
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n/an/a 1.70n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215447
PNG
(US9296745, 2)
Show SMILES CC(C)Cc1csc(n1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1S/C23H30N6OS/c1-15(2)12-17-14-31-22(24-17)21-25-18-7-8-19(26-20(18)27-21)29-11-5-6-16(13-29)23(30)28-9-3-4-10-28/h7-8,14-16H,3-6,9-13H2,1-2H3,(H,25,26,27)/t16-/m1/s1
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n/an/a 2.71n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215448
PNG
(US9296745, 3)
Show SMILES O=C([C@@H]1CCCN(C1)c1ccc2nc([nH]c2n1)-c1cccc(c1)-n1cccn1)N1CCCC1
Show InChI InChI=1S/C25H27N7O/c33-25(30-12-1-2-13-30)19-7-4-14-31(17-19)22-10-9-21-24(28-22)29-23(27-21)18-6-3-8-20(16-18)32-15-5-11-26-32/h3,5-6,8-11,15-16,19H,1-2,4,7,12-14,17H2,(H,27,28,29)/t19-/m1/s1
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n/an/a 4.82n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215449
PNG
(US9296745, 4)
Show SMILES CC(C)c1csc(n1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1S/C22H28N6OS/c1-14(2)17-13-30-21(24-17)20-23-16-7-8-18(25-19(16)26-20)28-11-5-6-15(12-28)22(29)27-9-3-4-10-27/h7-8,13-15H,3-6,9-12H2,1-2H3,(H,23,25,26)/t15-/m1/s1
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n/an/a 6.64n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215450
PNG
(US9296745, 5)
Show SMILES Cc1cccc(c1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1S/C23H27N5O/c1-16-6-4-7-17(14-16)21-24-19-9-10-20(25-22(19)26-21)28-13-5-8-18(15-28)23(29)27-11-2-3-12-27/h4,6-7,9-10,14,18H,2-3,5,8,11-13,15H2,1H3,(H,24,25,26)/t18-/m1/s1
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n/an/a 8.24n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215451
PNG
(US9296745, 6)
Show SMILES O=C([C@@H]1CCCN(C1)c1ccc2nc([nH]c2n1)-c1cccc(c1)-c1cnco1)N1CCCC1
Show InChI InChI=1S/C25H26N6O2/c32-25(30-10-1-2-11-30)19-7-4-12-31(15-19)22-9-8-20-24(28-22)29-23(27-20)18-6-3-5-17(13-18)21-14-26-16-33-21/h3,5-6,8-9,13-14,16,19H,1-2,4,7,10-12,15H2,(H,27,28,29)/t19-/m1/s1
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n/an/a 11.5n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215452
PNG
(US9296745, 7)
Show SMILES Clc1cncc(c1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1S/C21H23ClN6O/c22-16-10-15(11-23-12-16)19-24-17-5-6-18(25-20(17)26-19)28-9-3-4-14(13-28)21(29)27-7-1-2-8-27/h5-6,10-12,14H,1-4,7-9,13H2,(H,24,25,26)/t14-/m1/s1
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n/an/a 16.3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215453
PNG
(US9296745, 8)
Show SMILES CNS(=O)(=O)c1cccc(c1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1S/C23H28N6O3S/c1-24-33(31,32)18-8-4-6-16(14-18)21-25-19-9-10-20(26-22(19)27-21)29-13-5-7-17(15-29)23(30)28-11-2-3-12-28/h4,6,8-10,14,17,24H,2-3,5,7,11-13,15H2,1H3,(H,25,26,27)/t17-/m1/s1
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n/an/a 21.1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215454
PNG
(US9296745, 9)
Show SMILES O=C([C@@H]1CCCN(C1)c1ccc2nc([nH]c2n1)-c1cnn(c1)-c1ccccc1)N1CCCC1
Show InChI InChI=1S/C25H27N7O/c33-25(30-12-4-5-13-30)18-7-6-14-31(16-18)22-11-10-21-24(28-22)29-23(27-21)19-15-26-32(17-19)20-8-2-1-3-9-20/h1-3,8-11,15,17-18H,4-7,12-14,16H2,(H,27,28,29)/t18-/m1/s1
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n/an/a 22.1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215455
PNG
(US9296745, 10)
Show SMILES O=C([C@@H]1CCCN(C1)c1ccc2nc([nH]c2n1)-c1ccnc(n1)N1CCCC1)N1CCCC1
Show InChI InChI=1S/C24H30N8O/c33-23(30-11-1-2-12-30)17-6-5-15-32(16-17)20-8-7-18-22(28-20)29-21(26-18)19-9-10-25-24(27-19)31-13-3-4-14-31/h7-10,17H,1-6,11-16H2,(H,26,28,29)/t17-/m1/s1
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n/an/a 29.2n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215456
PNG
(US9296745, 11)
Show SMILES Cc1csc(n1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1S/C20H24N6OS/c1-13-12-28-19(21-13)18-22-15-6-7-16(23-17(15)24-18)26-10-4-5-14(11-26)20(27)25-8-2-3-9-25/h6-7,12,14H,2-5,8-11H2,1H3,(H,22,23,24)/t14-/m1/s1
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n/an/a 35n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215457
PNG
(US9296745, 12)
Show SMILES O=C([C@@H]1CCCN(C1)c1ccc2nc([nH]c2n1)-c1cccc2ccnn12)N1CCCC1
Show InChI InChI=1S/C23H25N7O/c31-23(28-12-1-2-13-28)16-5-4-14-29(15-16)20-9-8-18-21(26-20)27-22(25-18)19-7-3-6-17-10-11-24-30(17)19/h3,6-11,16H,1-2,4-5,12-15H2,(H,25,26,27)/t16-/m1/s1
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n/an/a 54.7n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215458
PNG
(US9296745, 13)
Show SMILES O=C([C@@H]1CCCN(C1)c1ccc2nc([nH]c2n1)-c1ccc(cc1)C#N)N1CCCC1
Show InChI InChI=1S/C23H24N6O/c24-14-16-5-7-17(8-6-16)21-25-19-9-10-20(26-22(19)27-21)29-13-3-4-18(15-29)23(30)28-11-1-2-12-28/h5-10,18H,1-4,11-13,15H2,(H,25,26,27)/t18-/m1/s1
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n/an/a 63.6n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215459
PNG
(US9296745, 14)
Show SMILES CC(C)(O)c1cc(ccn1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1S/C24H30N6O2/c1-24(2,32)19-14-16(9-10-25-19)21-26-18-7-8-20(27-22(18)28-21)30-13-5-6-17(15-30)23(31)29-11-3-4-12-29/h7-10,14,17,32H,3-6,11-13,15H2,1-2H3,(H,26,27,28)/t17-/m1/s1
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n/an/a 72.8n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215460
PNG
(US9296745, 15)
Show SMILES O=C([C@@H]1CCCN(C1)c1ccc2nc([nH]c2n1)-c1ccnc(NC2CC2)n1)N1CCCC1
Show InChI InChI=1S/C23H28N8O/c32-22(30-11-1-2-12-30)15-4-3-13-31(14-15)19-8-7-17-21(28-19)29-20(26-17)18-9-10-24-23(27-18)25-16-5-6-16/h7-10,15-16H,1-6,11-14H2,(H,24,25,27)(H,26,28,29)/t15-/m1/s1
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n/an/a 89.6n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215461
PNG
(US9296745, 16)
Show SMILES O=C([C@@H]1CCCN(C1)c1ccc2nc([nH]c2n1)-c1cncc(c1)C#N)N1CCCC1
Show InChI InChI=1S/C22H23N7O/c23-11-15-10-17(13-24-12-15)20-25-18-5-6-19(26-21(18)27-20)29-9-3-4-16(14-29)22(30)28-7-1-2-8-28/h5-6,10,12-13,16H,1-4,7-9,14H2,(H,25,26,27)/t16-/m1/s1
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n/an/a 102n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215462
PNG
(US9296745, 17)
Show SMILES Cc1nc(cs1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1S/C20H24N6OS/c1-13-21-16(12-28-13)19-22-15-6-7-17(23-18(15)24-19)26-10-4-5-14(11-26)20(27)25-8-2-3-9-25/h6-7,12,14H,2-5,8-11H2,1H3,(H,22,23,24)/t14-/m1/s1
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n/an/a 118n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215463
PNG
(US9296745, 18)
Show SMILES O=C([C@@H]1CCCN(C1)c1ccc2nc([nH]c2n1)[C@H]1C[C@H]1c1ccccc1)N1CCCC1
Show InChI InChI=1S/C25H29N5O/c31-25(29-12-4-5-13-29)18-9-6-14-30(16-18)22-11-10-21-24(27-22)28-23(26-21)20-15-19(20)17-7-2-1-3-8-17/h1-3,7-8,10-11,18-20H,4-6,9,12-16H2,(H,26,27,28)/t18-,19+,20+/m1/s1
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Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215464
PNG
(US9296745, 19)
Show SMILES O=C([C@@H]1CCCN(C1)c1ccc2nc([nH]c2n1)-c1ccc2nccn2c1)N1CCCC1
Show InChI InChI=1S/C23H25N7O/c31-23(28-10-1-2-11-28)17-4-3-12-29(15-17)20-8-6-18-22(26-20)27-21(25-18)16-5-7-19-24-9-13-30(19)14-16/h5-9,13-14,17H,1-4,10-12,15H2,(H,25,26,27)/t17-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215465
PNG
(US9296745, 20)
Show SMILES Cn1cc(Cl)c(n1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1S/C20H24ClN7O/c1-26-12-14(21)17(25-26)19-22-15-6-7-16(23-18(15)24-19)28-10-4-5-13(11-28)20(29)27-8-2-3-9-27/h6-7,12-13H,2-5,8-11H2,1H3,(H,22,23,24)/t13-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215466
PNG
(US9296745, 21)
Show SMILES Fc1ccccc1-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1S/C22H24FN5O/c23-17-8-2-1-7-16(17)20-24-18-9-10-19(25-21(18)26-20)28-13-5-6-15(14-28)22(29)27-11-3-4-12-27/h1-2,7-10,15H,3-6,11-14H2,(H,24,25,26)/t15-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215467
PNG
(US9296745, 22)
Show SMILES CC(C)(c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1)c1ccccc1
Show InChI InChI=1S/C25H31N5O/c1-25(2,19-10-4-3-5-11-19)24-26-20-12-13-21(27-22(20)28-24)30-16-8-9-18(17-30)23(31)29-14-6-7-15-29/h3-5,10-13,18H,6-9,14-17H2,1-2H3,(H,26,27,28)/t18-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215468
PNG
(US9296745, 23)
Show SMILES CC(C)c1cccc(-c2nc3ccc(nc3[nH]2)N2CCC[C@H](C2)C(=O)N2CCCC2)c1O
Show InChI InChI=1S/C25H31N5O2/c1-16(2)18-8-5-9-19(22(18)31)23-26-20-10-11-21(27-24(20)28-23)30-14-6-7-17(15-30)25(32)29-12-3-4-13-29/h5,8-11,16-17,31H,3-4,6-7,12-15H2,1-2H3,(H,26,27,28)/t17-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215469
PNG
(US9296745, 24)
Show SMILES CC(C)(C)c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1S/C20H29N5O/c1-20(2,3)19-21-15-8-9-16(22-17(15)23-19)25-12-6-7-14(13-25)18(26)24-10-4-5-11-24/h8-9,14H,4-7,10-13H2,1-3H3,(H,21,22,23)/t14-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215470
PNG
(US9296745, 25)
Show SMILES O=C([C@@H]1CCCN(C1)c1ccc2nc([nH]c2n1)-c1ccnc(n1)N1CCOCC1)N1CCCC1
Show InChI InChI=1S/C24H30N8O2/c33-23(30-9-1-2-10-30)17-4-3-11-32(16-17)20-6-5-18-22(28-20)29-21(26-18)19-7-8-25-24(27-19)31-12-14-34-15-13-31/h5-8,17H,1-4,9-16H2,(H,26,28,29)/t17-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215471
PNG
(US9296745, 26)
Show SMILES O=C([C@@H]1CCCN(C1)c1ccc2nc([nH]c2n1)C1CCCCC1)N1CCCC1
Show InChI InChI=1S/C22H31N5O/c28-22(26-12-4-5-13-26)17-9-6-14-27(15-17)19-11-10-18-21(24-19)25-20(23-18)16-7-2-1-3-8-16/h10-11,16-17H,1-9,12-15H2,(H,23,24,25)/t17-/m1/s1
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n/an/a 1.05E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215472
PNG
(US9296745, 27)
Show SMILES O=C([C@@H]1CCCN(C1)c1ccc2nc([nH]c2n1)-c1ccc2OCC(=O)Nc2c1)N1CCCC1
Show InChI InChI=1S/C24H26N6O3/c31-21-14-33-19-7-5-15(12-18(19)25-21)22-26-17-6-8-20(27-23(17)28-22)30-11-3-4-16(13-30)24(32)29-9-1-2-10-29/h5-8,12,16H,1-4,9-11,13-14H2,(H,25,31)(H,26,27,28)/t16-/m1/s1
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n/an/a 1.39E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215473
PNG
(US9296745, 28)
Show SMILES O=C([C@@H]1CCCN(C1)c1ccc2nc(CC3CCCCC3)[nH]c2n1)N1CCCC1
Show InChI InChI=1S/C23H33N5O/c29-23(27-12-4-5-13-27)18-9-6-14-28(16-18)21-11-10-19-22(26-21)25-20(24-19)15-17-7-2-1-3-8-17/h10-11,17-18H,1-9,12-16H2,(H,24,25,26)/t18-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215474
PNG
(US9296745, 29)
Show SMILES O=C([C@@H]1CCCN(C1)c1ccc2nc([nH]c2n1)C1CC1)N1CCCC1
Show InChI InChI=1S/C19H25N5O/c25-19(23-9-1-2-10-23)14-4-3-11-24(12-14)16-8-7-15-18(21-16)22-17(20-15)13-5-6-13/h7-8,13-14H,1-6,9-12H2,(H,20,21,22)/t14-/m1/s1
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n/an/a 4.37E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215475
PNG
(US9296745, 30)
Show SMILES CS(=O)(=O)Nc1cccc(c1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1S/C23H28N6O3S/c1-33(31,32)27-18-8-4-6-16(14-18)21-24-19-9-10-20(25-22(19)26-21)29-13-5-7-17(15-29)23(30)28-11-2-3-12-28/h4,6,8-10,14,17,27H,2-3,5,7,11-13,15H2,1H3,(H,24,25,26)/t17-/m1/s1
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n/an/a 1.40E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215476
PNG
(US9296745, 31)
Show SMILES CC(C)(C)OCc1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1S/C21H31N5O2/c1-21(2,3)28-14-17-22-16-8-9-18(24-19(16)23-17)26-12-6-7-15(13-26)20(27)25-10-4-5-11-25/h8-9,15H,4-7,10-14H2,1-3H3,(H,22,23,24)/t15-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215477
PNG
(US9296745, 32)
Show SMILES CCc1cc(no1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1S/C21H26N6O2/c1-2-15-12-17(25-29-15)20-22-16-7-8-18(23-19(16)24-20)27-11-5-6-14(13-27)21(28)26-9-3-4-10-26/h7-8,12,14H,2-6,9-11,13H2,1H3,(H,22,23,24)/t14-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215478
PNG
(US9296745, 33)
Show SMILES Cc1cncc(c1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1S/C22H26N6O/c1-15-11-17(13-23-12-15)20-24-18-6-7-19(25-21(18)26-20)28-10-4-5-16(14-28)22(29)27-8-2-3-9-27/h6-7,11-13,16H,2-5,8-10,14H2,1H3,(H,24,25,26)/t16-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215479
PNG
(US9296745, 34)
Show SMILES FC(F)(F)Oc1ccc(cc1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1S/C23H24F3N5O2/c24-23(25,26)33-17-7-5-15(6-8-17)20-27-18-9-10-19(28-21(18)29-20)31-13-3-4-16(14-31)22(32)30-11-1-2-12-30/h5-10,16H,1-4,11-14H2,(H,27,28,29)/t16-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215480
PNG
(US9296745, 35)
Show SMILES Fc1cccc(c1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1S/C22H24FN5O/c23-17-7-3-5-15(13-17)20-24-18-8-9-19(25-21(18)26-20)28-12-4-6-16(14-28)22(29)27-10-1-2-11-27/h3,5,7-9,13,16H,1-2,4,6,10-12,14H2,(H,24,25,26)/t16-/m1/s1
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n/an/a 21.2n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215481
PNG
(US9296745, 36)
Show SMILES COc1cccc(c1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1S/C23H27N5O2/c1-30-18-8-4-6-16(14-18)21-24-19-9-10-20(25-22(19)26-21)28-13-5-7-17(15-28)23(29)27-11-2-3-12-27/h4,6,8-10,14,17H,2-3,5,7,11-13,15H2,1H3,(H,24,25,26)/t17-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215482
PNG
(US9296745, 37)
Show SMILES COc1cccc(n1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1S/C22H26N6O2/c1-30-19-8-4-7-16(23-19)20-24-17-9-10-18(25-21(17)26-20)28-13-5-6-15(14-28)22(29)27-11-2-3-12-27/h4,7-10,15H,2-3,5-6,11-14H2,1H3,(H,24,25,26)/t15-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215483
PNG
(US9296745, 38)
Show SMILES O=C([C@@H]1CCCN(C1)c1ccc2nc([nH]c2n1)-c1cccc(n1)N1CCCC1)N1CCCC1
Show InChI InChI=1S/C25H31N7O/c33-25(31-14-3-4-15-31)18-7-6-16-32(17-18)22-11-10-20-24(28-22)29-23(27-20)19-8-5-9-21(26-19)30-12-1-2-13-30/h5,8-11,18H,1-4,6-7,12-17H2,(H,27,28,29)/t18-/m1/s1
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n/an/a 7.81n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215484
PNG
(US9296745, 39)
Show SMILES O=C([C@@H]1CCCN(C1)c1ccc2nc([nH]c2n1)-c1coc(n1)-c1ccccc1)N1CCCC1
Show InChI InChI=1S/C25H26N6O2/c32-25(30-12-4-5-13-30)18-9-6-14-31(15-18)21-11-10-19-22(28-21)29-23(26-19)20-16-33-24(27-20)17-7-2-1-3-8-17/h1-3,7-8,10-11,16,18H,4-6,9,12-15H2,(H,26,28,29)/t18-/m1/s1
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UniChem
n/an/a 6.85n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215485
PNG
(US9296745, 40)
Show SMILES CCc1csc(n1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1S/C21H26N6OS/c1-2-15-13-29-20(22-15)19-23-16-7-8-17(24-18(16)25-19)27-11-5-6-14(12-27)21(28)26-9-3-4-10-26/h7-8,13-14H,2-6,9-12H2,1H3,(H,23,24,25)/t14-/m1/s1
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UniChem
n/an/a 6.47n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215486
PNG
(US9296745, 154 | US9296745, 41)
Show SMILES Clc1cccc(c1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1S/C22H24ClN5O/c23-17-7-3-5-15(13-17)20-24-18-8-9-19(25-21(18)26-20)28-12-4-6-16(14-28)22(29)27-10-1-2-11-27/h3,5,7-9,13,16H,1-2,4,6,10-12,14H2,(H,24,25,26)/t16-/m1/s1
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n/an/a 4.56n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215487
PNG
(US9296745, 42)
Show SMILES CC(C)(C)c1csc(n1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1S/C23H30N6OS/c1-23(2,3)17-14-31-21(25-17)20-24-16-8-9-18(26-19(16)27-20)29-12-6-7-15(13-29)22(30)28-10-4-5-11-28/h8-9,14-15H,4-7,10-13H2,1-3H3,(H,24,26,27)/t15-/m1/s1
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n/an/a 3.18n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215488
PNG
(US9296745, 155 | US9296745, 43)
Show SMILES FC(F)Oc1cccc(c1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1S/C23H25F2N5O2/c24-23(25)32-17-7-3-5-15(13-17)20-26-18-8-9-19(27-21(18)28-20)30-12-4-6-16(14-30)22(31)29-10-1-2-11-29/h3,5,7-9,13,16,23H,1-2,4,6,10-12,14H2,(H,26,27,28)/t16-/m1/s1
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UniChem
n/an/a 7.41n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215489
PNG
(US9296745, 44)
Show SMILES Cc1cccc(n1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1S/C22H26N6O/c1-15-6-4-8-17(23-15)20-24-18-9-10-19(25-21(18)26-20)28-13-5-7-16(14-28)22(29)27-11-2-3-12-27/h4,6,8-10,16H,2-3,5,7,11-14H2,1H3,(H,24,25,26)/t16-/m1/s1
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n/an/a 36.5n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215490
PNG
(US9296745, 46)
Show SMILES Clc1ccc(Cc2nc3ccc(nc3[nH]2)N2CCC[C@H](C2)C(=O)N2CCCC2)cc1
Show InChI InChI=1S/C23H26ClN5O/c24-18-7-5-16(6-8-18)14-20-25-19-9-10-21(27-22(19)26-20)29-13-3-4-17(15-29)23(30)28-11-1-2-12-28/h5-10,17H,1-4,11-15H2,(H,25,26,27)/t17-/m1/s1
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n/an/a 188n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215491
PNG
(US9296745, 47)
Show SMILES O=C([C@@H]1CCCN(C1)c1ccc2nc([nH]c2n1)-c1cccc(c1)C#N)N1CCCC1
Show InChI InChI=1S/C23H24N6O/c24-14-16-5-3-6-17(13-16)21-25-19-8-9-20(26-22(19)27-21)29-12-4-7-18(15-29)23(30)28-10-1-2-11-28/h3,5-6,8-9,13,18H,1-2,4,7,10-12,15H2,(H,25,26,27)/t18-/m1/s1
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n/an/a 34.5n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215492
PNG
(US9296745, 48)
Show SMILES Clc1ccc(OCc2nc3ccc(nc3[nH]2)N2CCC[C@H](C2)C(=O)N2CCCC2)cc1
Show InChI InChI=1S/C23H26ClN5O2/c24-17-5-7-18(8-6-17)31-15-20-25-19-9-10-21(27-22(19)26-20)29-13-3-4-16(14-29)23(30)28-11-1-2-12-28/h5-10,16H,1-4,11-15H2,(H,25,26,27)/t16-/m1/s1
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n/an/a 10.7n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215493
PNG
(US9296745, 49)
Show SMILES O=C([C@@H]1CCCN(C1)c1ccc2nc([nH]c2n1)C1Cc2ccccc2C1)N1CCCC1
Show InChI InChI=1S/C25H29N5O/c31-25(29-11-3-4-12-29)19-8-5-13-30(16-19)22-10-9-21-24(27-22)28-23(26-21)20-14-17-6-1-2-7-18(17)15-20/h1-2,6-7,9-10,19-20H,3-5,8,11-16H2,(H,26,27,28)/t19-/m1/s1
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n/an/a 197n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
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