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Found 1750 hits Enz. Inhib. hit(s) with Target = 'Dihydroorotate Dehydrogenase (DHODH)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM14699
PNG
(1,3-diethyl 2-({8-thiatricyclo[7.4.0.0^{2,7}]tride...)
Show SMILES CCOC(=O)C(C=Nc1ccc2sc3ccccc3c2c1)C(=O)OCC
Show InChI InChI=1S/C20H19NO4S/c1-3-24-19(22)16(20(23)25-4-2)12-21-13-9-10-18-15(11-13)14-7-5-6-8-17(14)26-18/h5-12,16H,3-4H2,1-2H3
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UniChem
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PubMed
20 -43.9 160n/an/an/an/a8.025



University of Leeds



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 50: 186-91 (2007)


Article DOI: 10.1021/jm060687j
BindingDB Entry DOI: 10.7270/Q2T43RB5
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM14710
PNG
(ChemBridge compound no. 2 | N-(4-Bromo-2-methylphe...)
Show SMILES Cc1cc(Br)ccc1NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C18H14BrNO/c1-12-10-16(19)8-9-17(12)20-18(21)15-7-6-13-4-2-3-5-14(13)11-15/h2-11H,1H3,(H,20,21)
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20 -43.9 180n/an/an/an/a8.025



University of Leeds



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 50: 186-91 (2007)


Article DOI: 10.1021/jm060687j
BindingDB Entry DOI: 10.7270/Q2T43RB5
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM14711
PNG
(Asinex compound no. 6 | N-(3,5-Dichlorophenyl)-2-m...)
Show SMILES Cc1c(cccc1[N+]([O-])=O)C(=O)Nc1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C14H10Cl2N2O3/c1-8-12(3-2-4-13(8)18(20)21)14(19)17-11-6-9(15)5-10(16)7-11/h2-7H,1H3,(H,17,19)
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PubMed
30 -42.9 230n/an/an/an/a8.025



University of Leeds



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 50: 186-91 (2007)


Article DOI: 10.1021/jm060687j
BindingDB Entry DOI: 10.7270/Q2T43RB5
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM14701
PNG
(2-Cyano-3-(9-ethyl-9H-carbazol-3-ylamino)acrylic A...)
Show SMILES CCOC(=O)C(C=Nc1ccc2n(CC)c3ccccc3c2c1)C#N
Show InChI InChI=1S/C20H19N3O2/c1-3-23-18-8-6-5-7-16(18)17-11-15(9-10-19(17)23)22-13-14(12-21)20(24)25-4-2/h5-11,13-14H,3-4H2,1-2H3
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50 -41.7 440n/an/an/an/a8.025



University of Leeds



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 50: 186-91 (2007)


Article DOI: 10.1021/jm060687j
BindingDB Entry DOI: 10.7270/Q2T43RB5
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM29027
PNG
(cyanohydroxybutenamide, 17)
Show SMILES CC(=O)C(C#N)C(=O)Nc1ccc(cc1Cl)-c1ccccc1Cl
Show InChI InChI=1S/C17H12Cl2N2O2/c1-10(22)13(9-20)17(23)21-16-7-6-11(8-15(16)19)12-4-2-3-5-14(12)18/h2-8,13H,1H3,(H,21,23)
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480 -36.1 4.00E+3n/an/an/an/a8.025



University of Leeds



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 2683-93 (2009)


Article DOI: 10.1021/jm800963t
BindingDB Entry DOI: 10.7270/Q2PN93ZK
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Dihydroorotate dehydrogenase


(Homo sapiens (Human))
BDBM16094
PNG
(2-[(4-phenylbenzene)amido]benzoic acid | 2-[(biphe...)
Show SMILES OC(=O)c1ccccc1NC(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C20H15NO3/c22-19(21-18-9-5-4-8-17(18)20(23)24)16-12-10-15(11-13-16)14-6-2-1-3-7-14/h1-13H,(H,21,22)(H,23,24)
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PubMed
700 -35.1 5.00E+3n/an/an/an/a8.025



University of Leeds



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


Bioorg Med Chem Lett 16: 88-92 (2006)


Article DOI: 10.1016/j.bmcl.2005.09.045
BindingDB Entry DOI: 10.7270/Q2N29V6N
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM29028
PNG
(cyanohydroxybutenamide, 18)
Show SMILES CC(=O)C(C#N)C(=O)Nc1ccc(cc1C(F)(F)F)-c1ccccc1Cl
Show InChI InChI=1S/C18H12ClF3N2O2/c1-10(25)13(9-23)17(26)24-16-7-6-11(8-14(16)18(20,21)22)12-4-2-3-5-15(12)19/h2-8,13H,1H3,(H,24,26)
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PubMed
730 -35.0 6.20E+3n/an/an/an/a8.025



University of Leeds



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 2683-93 (2009)


Article DOI: 10.1021/jm800963t
BindingDB Entry DOI: 10.7270/Q2PN93ZK
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM29029
PNG
(cyanohydroxybutenamide, 19)
Show SMILES COc1ccccc1-c1ccc(NC(=O)C(C#N)C(C)=O)c(Cl)c1
Show InChI InChI=1S/C18H15ClN2O3/c1-11(22)14(10-20)18(23)21-16-8-7-12(9-15(16)19)13-5-3-4-6-17(13)24-2/h3-9,14H,1-2H3,(H,21,23)
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PubMed
1.00E+3 -34.2 8.60E+3n/an/an/an/a8.025



University of Leeds



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 2683-93 (2009)


Article DOI: 10.1021/jm800963t
BindingDB Entry DOI: 10.7270/Q2PN93ZK
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase


(Homo sapiens (Human))
BDBM16096
PNG
(2-[(6-bromonaphthalene-2-)amido]benzoic acid | 2-{...)
Show SMILES OC(=O)c1ccccc1NC(=O)c1ccc2cc(Br)ccc2c1
Show InChI InChI=1S/C18H12BrNO3/c19-14-8-7-11-9-13(6-5-12(11)10-14)17(21)20-16-4-2-1-3-15(16)18(22)23/h1-10H,(H,20,21)(H,22,23)
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1.10E+3 -34.0 8.40E+3n/an/an/an/a8.025



University of Leeds



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


Bioorg Med Chem Lett 16: 88-92 (2006)


Article DOI: 10.1016/j.bmcl.2005.09.045
BindingDB Entry DOI: 10.7270/Q2N29V6N
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM29030
PNG
(cyanohydroxybutenamide, 20)
Show SMILES CC(=O)C(C#N)C(=O)Nc1ccc(cc1Cl)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C17H11Cl3N2O2/c1-9(23)12(8-21)17(24)22-15-6-5-10(7-14(15)19)11-3-2-4-13(18)16(11)20/h2-7,12H,1H3,(H,22,24)
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1.20E+3 -33.8 9.90E+3n/an/an/an/a8.025



University of Leeds



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 2683-93 (2009)


Article DOI: 10.1021/jm800963t
BindingDB Entry DOI: 10.7270/Q2PN93ZK
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM29031
PNG
(cyanohydroxybutenamide, 21)
Show SMILES CC(=O)C(C#N)C(=O)Nc1ccc(cc1Cl)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C17H11Cl3N2O2/c1-9(23)11(8-21)17(24)22-15-6-5-10(7-14(15)20)16-12(18)3-2-4-13(16)19/h2-7,11H,1H3,(H,22,24)
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1.20E+3 -33.8 1.02E+4n/an/an/an/a8.025



University of Leeds



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 2683-93 (2009)


Article DOI: 10.1021/jm800963t
BindingDB Entry DOI: 10.7270/Q2PN93ZK
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Dihydroorotate dehydrogenase


(Homo sapiens (Human))
BDBM16098
PNG
(2-(naphthalene-2-amido)benzoic acid | 2-[(naphthal...)
Show SMILES OC(=O)c1ccccc1NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C18H13NO3/c20-17(19-16-8-4-3-7-15(16)18(21)22)14-10-9-12-5-1-2-6-13(12)11-14/h1-11H,(H,19,20)(H,21,22)
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1.80E+3 -32.8 1.38E+4n/an/an/an/a8.025



University of Leeds



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


Bioorg Med Chem Lett 16: 88-92 (2006)


Article DOI: 10.1016/j.bmcl.2005.09.045
BindingDB Entry DOI: 10.7270/Q2N29V6N
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM14708
PNG
(Ethyl 3-(biphenyl-3-ylamino)-2-cyanoacrylate | bip...)
Show SMILES CCOC(=O)C(C=Nc1cccc(c1)-c1ccccc1)C#N
Show InChI InChI=1S/C18H16N2O2/c1-2-22-18(21)16(12-19)13-20-17-10-6-9-15(11-17)14-7-4-3-5-8-14/h3-11,13,16H,2H2,1H3
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2.45E+3 -32.0 2.13E+4n/an/an/an/a8.025



University of Leeds



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 50: 186-91 (2007)


Article DOI: 10.1021/jm060687j
BindingDB Entry DOI: 10.7270/Q2T43RB5
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase


(Homo sapiens (Human))
BDBM16099
PNG
(3-carbamoyl-5-(4-phenylphenyl)benzoic acid | 5-car...)
Show SMILES NC(=O)c1cc(cc(c1)-c1ccc(cc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C20H15NO3/c21-19(22)17-10-16(11-18(12-17)20(23)24)15-8-6-14(7-9-15)13-4-2-1-3-5-13/h1-12H,(H2,21,22)(H,23,24)
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PubMed
2.80E+3 -31.4n/an/an/an/an/a8.022



Cornell University



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


Bioorg Med Chem Lett 16: 1610-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.029
BindingDB Entry DOI: 10.7270/Q2H993FV
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM29025
PNG
(cyanohydroxybutenamide, 10)
Show SMILES CC(=O)C(C#N)C(=O)Nc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C17H14N2O2/c1-12(20)16(11-18)17(21)19-15-9-7-14(8-10-15)13-5-3-2-4-6-13/h2-10,16H,1H3,(H,19,21)
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3.00E+3 -31.5 2.57E+4n/an/an/an/a8.025



University of Leeds



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 2683-93 (2009)


Article DOI: 10.1021/jm800963t
BindingDB Entry DOI: 10.7270/Q2PN93ZK
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM29036
PNG
(cyanohydroxybutenamide, 26)
Show SMILES CC(=O)C(C#N)C(=O)Nc1ccc(cc1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C17H12Cl2N2O2/c1-10(22)14(9-20)17(23)21-12-7-5-11(6-8-12)13-3-2-4-15(18)16(13)19/h2-8,14H,1H3,(H,21,23)
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3.20E+3 -31.4 2.72E+4n/an/an/an/a8.025



University of Leeds



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 2683-93 (2009)


Article DOI: 10.1021/jm800963t
BindingDB Entry DOI: 10.7270/Q2PN93ZK
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM14702
PNG
(1,3-diethyl 2-[(1H-indazol-5-ylamino)methylidene]p...)
Show SMILES CCOC(=O)C(C=Nc1ccc2n[nH]cc2c1)C(=O)OCC
Show InChI InChI=1S/C15H17N3O4/c1-3-21-14(19)12(15(20)22-4-2)9-16-11-5-6-13-10(7-11)8-17-18-13/h5-9,12H,3-4H2,1-2H3,(H,17,18)
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3.20E+3 -31.4 2.78E+4n/an/an/an/a8.025



University of Leeds



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 50: 186-91 (2007)


Article DOI: 10.1021/jm060687j
BindingDB Entry DOI: 10.7270/Q2T43RB5
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase


(Homo sapiens (Human))
BDBM16103
PNG
(3-carbamoyl-5-[3-(3-methylphenyl)phenyl]benzoic ac...)
Show SMILES Cc1cccc(c1)-c1cccc(c1)-c1cc(cc(c1)C(O)=O)C(N)=O
Show InChI InChI=1S/C21H17NO3/c1-13-4-2-5-14(8-13)15-6-3-7-16(9-15)17-10-18(20(22)23)12-19(11-17)21(24)25/h2-12H,1H3,(H2,22,23)(H,24,25)
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3.70E+3 -30.7n/an/an/an/an/a8.022



Cornell University



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


Bioorg Med Chem Lett 16: 1610-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.029
BindingDB Entry DOI: 10.7270/Q2H993FV
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase


(Homo sapiens (Human))
BDBM16104
PNG
(3-[3-(4-tert-butylphenyl)phenyl]-5-carbamoylbenzoi...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cccc(c1)-c1cc(cc(c1)C(O)=O)C(N)=O
Show InChI InChI=1S/C24H23NO3/c1-24(2,3)21-9-7-15(8-10-21)16-5-4-6-17(11-16)18-12-19(22(25)26)14-20(13-18)23(27)28/h4-14H,1-3H3,(H2,25,26)(H,27,28)
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4.00E+3 -30.5n/an/an/an/an/a8.022



Cornell University



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


Bioorg Med Chem Lett 16: 1610-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.029
BindingDB Entry DOI: 10.7270/Q2H993FV
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase


(Homo sapiens (Human))
BDBM16101
PNG
(3-carbamoyl-5-[3-(4-methylphenyl)phenyl]benzoic ac...)
Show SMILES Cc1ccc(cc1)-c1cccc(c1)-c1cc(cc(c1)C(O)=O)C(N)=O
Show InChI InChI=1S/C21H17NO3/c1-13-5-7-14(8-6-13)15-3-2-4-16(9-15)17-10-18(20(22)23)12-19(11-17)21(24)25/h2-12H,1H3,(H2,22,23)(H,24,25)
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4.00E+3 -30.5n/an/an/an/an/a8.022



Cornell University



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


Bioorg Med Chem Lett 16: 1610-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.029
BindingDB Entry DOI: 10.7270/Q2H993FV
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM14703
PNG
(1,3-diethyl 2-{[(4-methylphenyl)amino]methylidene}...)
Show SMILES CCOC(=O)C(C=Nc1ccc(C)cc1)C(=O)OCC
Show InChI InChI=1S/C15H19NO4/c1-4-19-14(17)13(15(18)20-5-2)10-16-12-8-6-11(3)7-9-12/h6-10,13H,4-5H2,1-3H3
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PubMed
4.60E+3 -30.5 4.00E+4n/an/an/an/a8.025



University of Leeds



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 50: 186-91 (2007)


Article DOI: 10.1021/jm060687j
BindingDB Entry DOI: 10.7270/Q2T43RB5
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM16093
PNG
(2-[(biphenyl-4-ylcarbonyl)(methyl)amino]benzoic ac...)
Show SMILES CN(C(=O)c1ccc(cc1)-c1ccccc1)c1ccccc1C(O)=O
Show InChI InChI=1S/C21H17NO3/c1-22(19-10-6-5-9-18(19)21(24)25)20(23)17-13-11-16(12-14-17)15-7-3-2-4-8-15/h2-14H,1H3,(H,24,25)
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PubMed
4.90E+3 -30.3 4.26E+4n/an/an/an/a8.025



University of Leeds



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


Bioorg Med Chem Lett 16: 88-92 (2006)


Article DOI: 10.1016/j.bmcl.2005.09.045
BindingDB Entry DOI: 10.7270/Q2N29V6N
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM29037
PNG
(cyanohydroxybutenamide, 27)
Show SMILES CC(=O)C(C#N)C(=O)Nc1ccc(cc1)-c1ccccc1Cl
Show InChI InChI=1S/C17H13ClN2O2/c1-11(21)15(10-19)17(22)20-13-8-6-12(7-9-13)14-4-2-3-5-16(14)18/h2-9,15H,1H3,(H,20,22)
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PubMed
5.60E+3 -30.0 4.74E+4n/an/an/an/a8.025



University of Leeds



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 2683-93 (2009)


Article DOI: 10.1021/jm800963t
BindingDB Entry DOI: 10.7270/Q2PN93ZK
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM29032
PNG
(cyanohydroxybutenamide, 22)
Show SMILES CC(=O)C(C#N)C(=O)Nc1ccc(cc1Cl)-c1cccc(Cl)c1
Show InChI InChI=1S/C17H12Cl2N2O2/c1-10(22)14(9-20)17(23)21-16-6-5-12(8-15(16)19)11-3-2-4-13(18)7-11/h2-8,14H,1H3,(H,21,23)
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PubMed
5.80E+3 -29.9 4.91E+4n/an/an/an/a8.025



University of Leeds



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 2683-93 (2009)


Article DOI: 10.1021/jm800963t
BindingDB Entry DOI: 10.7270/Q2PN93ZK
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM29038
PNG
(cyanohydroxybutenamide, 28)
Show SMILES CC(=O)C(C#N)C(=O)Nc1ccc(cc1Cl)-c1ccccc1
Show InChI InChI=1S/C17H13ClN2O2/c1-11(21)14(10-19)17(22)20-16-8-7-13(9-15(16)18)12-5-3-2-4-6-12/h2-9,14H,1H3,(H,20,22)
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PubMed
6.00E+3 -29.8 5.11E+4n/an/an/an/a8.025



University of Leeds



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 2683-93 (2009)


Article DOI: 10.1021/jm800963t
BindingDB Entry DOI: 10.7270/Q2PN93ZK
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Dihydroorotate dehydrogenase


(Homo sapiens (Human))
BDBM16105
PNG
(3-carbamoyl-5-{3-[4-(trifluoromethyl)phenyl]phenyl...)
Show SMILES NC(=O)c1cc(cc(c1)-c1cccc(c1)-c1ccc(cc1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C21H14F3NO3/c22-21(23,24)18-6-4-12(5-7-18)13-2-1-3-14(8-13)15-9-16(19(25)26)11-17(10-15)20(27)28/h1-11H,(H2,25,26)(H,27,28)
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PubMed
6.00E+3 -29.5n/an/an/an/an/a8.022



Cornell University



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


Bioorg Med Chem Lett 16: 1610-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.029
BindingDB Entry DOI: 10.7270/Q2H993FV
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM29033
PNG
(cyanohydroxybutenamide, 23)
Show SMILES CC(=O)C(C#N)C(=O)Nc1ccc(cc1C(F)(F)F)-c1cccc(Cl)c1
Show InChI InChI=1S/C18H12ClF3N2O2/c1-10(25)14(9-23)17(26)24-16-6-5-12(8-15(16)18(20,21)22)11-3-2-4-13(19)7-11/h2-8,14H,1H3,(H,24,26)
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PubMed
6.80E+3 -29.5 5.72E+4n/an/an/an/a8.025



University of Leeds



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 2683-93 (2009)


Article DOI: 10.1021/jm800963t
BindingDB Entry DOI: 10.7270/Q2PN93ZK
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM14709
PNG
(1,3-diethyl 2-{[(3-phenylphenyl)amino]methylidene}...)
Show SMILES CCOC(=O)C(C=Nc1cccc(c1)-c1ccccc1)C(=O)OCC
Show InChI InChI=1S/C20H21NO4/c1-3-24-19(22)18(20(23)25-4-2)14-21-17-12-8-11-16(13-17)15-9-6-5-7-10-15/h5-14,18H,3-4H2,1-2H3
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PubMed
1.00E+4 -28.5 8.67E+4n/an/an/an/a8.025



University of Leeds



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 50: 186-91 (2007)


Article DOI: 10.1021/jm060687j
BindingDB Entry DOI: 10.7270/Q2T43RB5
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM16095
PNG
(2-[(6-bromonaphthalene-2-)(methyl)amido]benzoic ac...)
Show SMILES CN(C(=O)c1ccc2cc(Br)ccc2c1)c1ccccc1C(O)=O
Show InChI InChI=1S/C19H14BrNO3/c1-21(17-5-3-2-4-16(17)19(23)24)18(22)14-7-6-13-11-15(20)9-8-12(13)10-14/h2-11H,1H3,(H,23,24)
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PubMed
1.08E+4 -28.3 9.34E+4n/an/an/an/a8.025



University of Leeds



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


Bioorg Med Chem Lett 16: 88-92 (2006)


Article DOI: 10.1016/j.bmcl.2005.09.045
BindingDB Entry DOI: 10.7270/Q2N29V6N
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM29024
PNG
(CHEMBL141732 | cyanocyclopropylpropenamide, 4)
Show SMILES FC(F)(F)c1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1
Show InChI InChI=1S/C14H11F3N2O2/c15-14(16,17)9-3-5-10(6-4-9)19-13(21)11(7-18)12(20)8-1-2-8/h3-6,8,11H,1-2H2,(H,19,21)
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PubMed
1.10E+4 -28.3 9.25E+4n/an/an/an/a8.025



University of Leeds



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 2683-93 (2009)


Article DOI: 10.1021/jm800963t
BindingDB Entry DOI: 10.7270/Q2PN93ZK
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM16096
PNG
(2-[(6-bromonaphthalene-2-)amido]benzoic acid | 2-{...)
Show SMILES OC(=O)c1ccccc1NC(=O)c1ccc2cc(Br)ccc2c1
Show InChI InChI=1S/C18H12BrNO3/c19-14-8-7-11-9-13(6-5-12(11)10-14)17(21)20-16-4-2-1-3-15(16)18(22)23/h1-10H,(H,20,21)(H,22,23)
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PubMed
1.64E+4 -27.3 1.43E+5n/an/an/an/a8.025



University of Leeds



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


Bioorg Med Chem Lett 16: 88-92 (2006)


Article DOI: 10.1016/j.bmcl.2005.09.045
BindingDB Entry DOI: 10.7270/Q2N29V6N
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM16094
PNG
(2-[(4-phenylbenzene)amido]benzoic acid | 2-[(biphe...)
Show SMILES OC(=O)c1ccccc1NC(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C20H15NO3/c22-19(21-18-9-5-4-8-17(18)20(23)24)16-12-10-15(11-13-16)14-6-2-1-3-7-14/h1-13H,(H,21,22)(H,23,24)
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PubMed
1.77E+4 -27.1 1.54E+5n/an/an/an/a8.025



University of Leeds



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


Bioorg Med Chem Lett 16: 88-92 (2006)


Article DOI: 10.1016/j.bmcl.2005.09.045
BindingDB Entry DOI: 10.7270/Q2N29V6N
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase


(Homo sapiens (Human))
BDBM16102
PNG
(3-carbamoyl-5-(3-phenylphenyl)benzoic acid | 5-car...)
Show SMILES NC(=O)c1cc(cc(c1)-c1cccc(c1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C20H15NO3/c21-19(22)17-10-16(11-18(12-17)20(23)24)15-8-4-7-14(9-15)13-5-2-1-3-6-13/h1-12H,(H2,21,22)(H,23,24)
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PubMed
2.00E+4 -26.6n/an/an/an/an/a8.022



Cornell University



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


Bioorg Med Chem Lett 16: 1610-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.029
BindingDB Entry DOI: 10.7270/Q2H993FV
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM29034
PNG
(cyanohydroxybutenamide, 24)
Show SMILES CC(=O)C(C#N)C(=O)Nc1ccc(c(Cl)c1)-c1ccccc1Cl
Show InChI InChI=1S/C17H12Cl2N2O2/c1-10(22)14(9-20)17(23)21-11-6-7-13(16(19)8-11)12-4-2-3-5-15(12)18/h2-8,14H,1H3,(H,21,23)
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PubMed
2.05E+4 -26.8 1.65E+5n/an/an/an/a8.025



University of Leeds



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 2683-93 (2009)


Article DOI: 10.1021/jm800963t
BindingDB Entry DOI: 10.7270/Q2PN93ZK
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM29039
PNG
(cyanohydroxybutenamide, 29)
Show SMILES CCOc1cccc(c1)-c1ccc(NC(=O)C(C#N)C(C)=O)cc1
Show InChI InChI=1S/C19H18N2O3/c1-3-24-17-6-4-5-15(11-17)14-7-9-16(10-8-14)21-19(23)18(12-20)13(2)22/h4-11,18H,3H2,1-2H3,(H,21,23)
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PubMed
2.15E+4 -26.6 1.82E+5n/an/an/an/a8.025



University of Leeds



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 2683-93 (2009)


Article DOI: 10.1021/jm800963t
BindingDB Entry DOI: 10.7270/Q2PN93ZK
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM14712
PNG
((2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)pheny...)
Show SMILES CC(=O)C(C#N)C(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C12H9F3N2O2/c1-7(18)10(6-16)11(19)17-9-4-2-8(3-5-9)12(13,14)15/h2-5,10H,1H3,(H,17,19)
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PubMed
2.20E+4 -26.6 1.90E+5n/an/an/an/a8.025



University of Leeds



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 2683-93 (2009)


Article DOI: 10.1021/jm800963t
BindingDB Entry DOI: 10.7270/Q2PN93ZK
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM14712
PNG
((2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)pheny...)
Show SMILES CC(=O)C(C#N)C(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C12H9F3N2O2/c1-7(18)10(6-16)11(19)17-9-4-2-8(3-5-9)12(13,14)15/h2-5,10H,1H3,(H,17,19)
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PubMed
2.34E+4 -26.4 1.90E+5n/an/an/an/a8.025



University of Leeds



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 50: 186-91 (2007)


Article DOI: 10.1021/jm060687j
BindingDB Entry DOI: 10.7270/Q2T43RB5
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM29026
PNG
(CHEMBL142996 | cyanocyclopropylpropenamide, 11)
Show SMILES O=C(Nc1ccc(cc1)-c1ccccc1)C(C#N)C(=O)C1CC1
Show InChI InChI=1S/C19H16N2O2/c20-12-17(18(22)15-6-7-15)19(23)21-16-10-8-14(9-11-16)13-4-2-1-3-5-13/h1-5,8-11,15,17H,6-7H2,(H,21,23)
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PubMed
2.60E+4 -26.2 2.24E+5n/an/an/an/a8.025



University of Leeds



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 2683-93 (2009)


Article DOI: 10.1021/jm800963t
BindingDB Entry DOI: 10.7270/Q2PN93ZK
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM29035
PNG
(cyanohydroxybutenamide, 25)
Show SMILES CC(=O)C(C#N)C(=O)Nc1ccc(c(Cl)c1)-c1cccc(Cl)c1
Show InChI InChI=1S/C17H12Cl2N2O2/c1-10(22)15(9-20)17(23)21-13-5-6-14(16(19)8-13)11-3-2-4-12(18)7-11/h2-8,15H,1H3,(H,21,23)
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PubMed
2.80E+4 -26.0 2.37E+5n/an/an/an/a8.025



University of Leeds



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 2683-93 (2009)


Article DOI: 10.1021/jm800963t
BindingDB Entry DOI: 10.7270/Q2PN93ZK
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM14704
PNG
(1,3-diethyl 2-{[(2-methylphenyl)amino]methylidene}...)
Show SMILES CCOC(=O)C(C=Nc1ccccc1C)C(=O)OCC
Show InChI InChI=1S/C15H19NO4/c1-4-19-14(17)12(15(18)20-5-2)10-16-13-9-7-6-8-11(13)3/h6-10,12H,4-5H2,1-3H3
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PubMed
3.97E+4 -25.1 3.46E+5n/an/an/an/a8.025



University of Leeds



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 50: 186-91 (2007)


Article DOI: 10.1021/jm060687j
BindingDB Entry DOI: 10.7270/Q2T43RB5
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM14705
PNG
(1,3-diethyl 2-[(1H-1,3-benzodiazol-5-ylamino)methy...)
Show SMILES CCOC(=O)C(C=Nc1ccc2nc[nH]c2c1)C(=O)OCC
Show InChI InChI=1S/C15H17N3O4/c1-3-21-14(19)11(15(20)22-4-2)8-16-10-5-6-12-13(7-10)18-9-17-12/h5-9,11H,3-4H2,1-2H3,(H,17,18)
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4.02E+4 -25.1 3.49E+5n/an/an/an/a8.025



University of Leeds



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 50: 186-91 (2007)


Article DOI: 10.1021/jm060687j
BindingDB Entry DOI: 10.7270/Q2T43RB5
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase


(Homo sapiens (Human))
BDBM16108
PNG
(3-carbamoyl-5-[4-(4-methylphenyl)phenyl]benzoic ac...)
Show SMILES Cc1ccc(cc1)-c1ccc(cc1)-c1cc(cc(c1)C(O)=O)C(N)=O
Show InChI InChI=1S/C21H17NO3/c1-13-2-4-14(5-3-13)15-6-8-16(9-7-15)17-10-18(20(22)23)12-19(11-17)21(24)25/h2-12H,1H3,(H2,22,23)(H,24,25)
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Article
PubMed
>1.00E+5>-22.6n/an/an/an/an/a8.022



Cornell University



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


Bioorg Med Chem Lett 16: 1610-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.029
BindingDB Entry DOI: 10.7270/Q2H993FV
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase


(Homo sapiens (Human))
BDBM16106
PNG
(3-carbamoyl-5-{4-[4-(trifluoromethyl)phenyl]phenyl...)
Show SMILES NC(=O)c1cc(cc(c1)-c1ccc(cc1)-c1ccc(cc1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C21H14F3NO3/c22-21(23,24)18-7-5-13(6-8-18)12-1-3-14(4-2-12)15-9-16(19(25)26)11-17(10-15)20(27)28/h1-11H,(H2,25,26)(H,27,28)
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>1.00E+5>-22.6n/an/an/an/an/a8.022



Cornell University



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


Bioorg Med Chem Lett 16: 1610-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.029
BindingDB Entry DOI: 10.7270/Q2H993FV
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase


(Homo sapiens (Human))
BDBM16107
PNG
(3-[4-(4-tert-butylphenyl)phenyl]-5-carbamoylbenzoi...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1ccc(cc1)-c1cc(cc(c1)C(O)=O)C(N)=O
Show InChI InChI=1S/C24H23NO3/c1-24(2,3)21-10-8-16(9-11-21)15-4-6-17(7-5-15)18-12-19(22(25)26)14-20(13-18)23(27)28/h4-14H,1-3H3,(H2,25,26)(H,27,28)
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>1.00E+5>-22.6n/an/an/an/an/a8.022



Cornell University



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


Bioorg Med Chem Lett 16: 1610-5 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.029
BindingDB Entry DOI: 10.7270/Q2H993FV
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase


(Homo sapiens (Human))
BDBM119809
PNG
(US8691852, 13)
Show SMILES COc1cccc(c1)-c1ccc(Nc2ncccc2C(O)=O)c(Cl)c1
Show InChI InChI=1S/C19H15ClN2O3/c1-25-14-5-2-4-12(10-14)13-7-8-17(16(20)11-13)22-18-15(19(23)24)6-3-9-21-18/h2-11H,1H3,(H,21,22)(H,23,24)
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n/an/a 150n/an/an/an/a8.0n/a



Amirall, S.A.

US Patent


Assay Description
DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichlorophenol-indophenol). The substrate oxidation (...


US Patent US8691852 (2014)


BindingDB Entry DOI: 10.7270/Q2GB22QD
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase


(Homo sapiens (Human))
BDBM119810
PNG
(US8691852, 17)
Show SMILES OC(=O)c1cccnc1Nc1c(F)cc(cc1F)-c1cccc(OC2CCC2)c1
Show InChI InChI=1S/C22H18F2N2O3/c23-18-11-14(13-4-1-7-16(10-13)29-15-5-2-6-15)12-19(24)20(18)26-21-17(22(27)28)8-3-9-25-21/h1,3-4,7-12,15H,2,5-6H2,(H,25,26)(H,27,28)
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n/an/a 90n/an/an/an/a8.0n/a



Amirall, S.A.

US Patent


Assay Description
DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichlorophenol-indophenol). The substrate oxidation (...


US Patent US8691852 (2014)


BindingDB Entry DOI: 10.7270/Q2GB22QD
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase


(Homo sapiens (Human))
BDBM119811
PNG
(US8691852, 19)
Show SMILES CCOc1cccc(c1)-c1cc(F)c(Nc2ncccc2C(O)=O)c(F)c1
Show InChI InChI=1S/C20H16F2N2O3/c1-2-27-14-6-3-5-12(9-14)13-10-16(21)18(17(22)11-13)24-19-15(20(25)26)7-4-8-23-19/h3-11H,2H2,1H3,(H,23,24)(H,25,26)
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n/an/a 19n/an/an/an/a8.0n/a



Amirall, S.A.

US Patent


Assay Description
DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichlorophenol-indophenol). The substrate oxidation (...


US Patent US8691852 (2014)


BindingDB Entry DOI: 10.7270/Q2GB22QD
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase


(Homo sapiens (Human))
BDBM119812
PNG
(US8691852, 20)
Show SMILES COc1cccc(c1)-c1cc(F)c(Nc2ncccc2C(O)=O)c(F)c1
Show InChI InChI=1S/C19H14F2N2O3/c1-26-13-5-2-4-11(8-13)12-9-15(20)17(16(21)10-12)23-18-14(19(24)25)6-3-7-22-18/h2-10H,1H3,(H,22,23)(H,24,25)
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n/an/a 15n/an/an/an/a8.0n/a



Amirall, S.A.

US Patent


Assay Description
DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichlorophenol-indophenol). The substrate oxidation (...


US Patent US8691852 (2014)


BindingDB Entry DOI: 10.7270/Q2GB22QD
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase


(Homo sapiens (Human))
BDBM119813
PNG
(US8691852, 21)
Show SMILES [Li]OC(=O)c1ccncc1Nc1ccc(cc1F)-c1cccc(OCC)c1
Show InChI InChI=1S/C20H17FN2O3.Li/c1-2-26-15-5-3-4-13(10-15)14-6-7-18(17(21)11-14)23-19-12-22-9-8-16(19)20(24)25;/h3-12,23H,2H2,1H3,(H,24,25);/q;+1/p-1
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n/an/a 19n/an/an/an/a8.0n/a



Amirall, S.A.

US Patent


Assay Description
DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichlorophenol-indophenol). The substrate oxidation (...


US Patent US8691852 (2014)


BindingDB Entry DOI: 10.7270/Q2GB22QD
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase


(Homo sapiens (Human))
BDBM119814
PNG
(US8691852, 23)
Show SMILES [Li]OC(=O)c1ccncc1Nc1ccc(cc1OC(F)(F)F)-c1cccc(OC)c1
Show InChI InChI=1S/C20H15F3N2O4.Li/c1-28-14-4-2-3-12(9-14)13-5-6-16(18(10-13)29-20(21,22)23)25-17-11-24-8-7-15(17)19(26)27;/h2-11,25H,1H3,(H,26,27);/q;+1/p-1
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n/an/a 14n/an/an/an/a8.0n/a



Amirall, S.A.

US Patent


Assay Description
DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichlorophenol-indophenol). The substrate oxidation (...


US Patent US8691852 (2014)


BindingDB Entry DOI: 10.7270/Q2GB22QD
More data for this
Ligand-Target Pair
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