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Found 17 hits Enz. Inhib. hit(s) with Target = 'Ephrin type-A receptor 4 ligand binding domain (EphA4-LBD)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ephrin type-A receptor 4 ligand binding domain (EphA4-LBD)


(Homo sapiens (Human))
BDBM223310
PNG
(123C7)
Show SMILES COc1ccc2c(CCNC(=O)[C@H](Cc3ccncc3)NC(=O)[C@H](Cc3ccc(Cl)cc3)NC(=O)[C@H](Cc3c[nH]c4ccc(O)cc34)NC(=O)CCCN)c[nH]c2c1
Show InChI InChI=1S/C43H47ClN8O6/c1-58-32-9-10-33-28(24-49-36(33)23-32)14-18-47-41(55)37(20-27-12-16-46-17-13-27)51-42(56)38(19-26-4-6-30(44)7-5-26)52-43(57)39(50-40(54)3-2-15-45)21-29-25-48-35-11-8-31(53)22-34(29)35/h4-13,16-17,22-25,37-39,48-49,53H,2-3,14-15,18-21,45H2,1H3,(H,47,55)(H,50,54)(H,51,56)(H,52,57)/t37-,38-,39-/m0/s1
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n/an/an/a 540n/an/an/a6.527



Sanford-Burnham-Prebys Medical Discovery Institute



Assay Description
The purified EphA proteins (EphA4-LBD, EphA3-LBD, and EphA2-LBD) were dissolved in 50 mM potassium phosphate buffer (pH 6.5) containing 100 mM NaCl. ...


Cell Chem Biol 24: 293-305 (2017)


Article DOI: 10.1016/j.chembiol.2017.01.006
BindingDB Entry DOI: 10.7270/Q2GX49FB
More data for this
Ligand-Target Pair
Ephrin type-A receptor 4 ligand binding domain (EphA4-LBD)


(Homo sapiens (Human))
BDBM223311
PNG
(123C4)
Show SMILES COc1ccc2[nH]cc(CCNC(=O)[C@H](Cc3ccncc3)NC(=O)[C@H](Cc3ccc(Cl)cc3)NC(=O)[C@H](Cc3c[nH]c4ccc(O)cc34)NC(=O)CCCN)c2c1
Show InChI InChI=1S/C43H47ClN8O6/c1-58-32-9-11-36-34(23-32)28(24-48-36)14-18-47-41(55)37(20-27-12-16-46-17-13-27)51-42(56)38(19-26-4-6-30(44)7-5-26)52-43(57)39(50-40(54)3-2-15-45)21-29-25-49-35-10-8-31(53)22-33(29)35/h4-13,16-17,22-25,37-39,48-49,53H,2-3,14-15,18-21,45H2,1H3,(H,47,55)(H,50,54)(H,51,56)(H,52,57)/t37-,38-,39-/m0/s1
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n/an/an/a 420n/an/an/a6.527



Sanford-Burnham-Prebys Medical Discovery Institute



Assay Description
The purified EphA proteins (EphA4-LBD, EphA3-LBD, and EphA2-LBD) were dissolved in 50 mM potassium phosphate buffer (pH 6.5) containing 100 mM NaCl. ...


Cell Chem Biol 24: 293-305 (2017)


Article DOI: 10.1016/j.chembiol.2017.01.006
BindingDB Entry DOI: 10.7270/Q2GX49FB
More data for this
Ligand-Target Pair
Ephrin type-A receptor 4 ligand binding domain (EphA4-LBD)


(Homo sapiens (Human))
BDBM223308
PNG
(123C5)
Show SMILES NCCCC(=O)N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccncc1)C(=O)NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C42H45ClN8O6/c43-29-5-3-25(4-6-29)18-37(51-42(57)38(49-39(54)2-1-14-44)20-28-24-48-35-10-8-31(53)22-33(28)35)41(56)50-36(19-26-11-15-45-16-12-26)40(55)46-17-13-27-23-47-34-9-7-30(52)21-32(27)34/h3-12,15-16,21-24,36-38,47-48,52-53H,1-2,13-14,17-20,44H2,(H,46,55)(H,49,54)(H,50,56)(H,51,57)/t36-,37-,38-/m0/s1
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n/an/an/a 2.20E+3n/an/an/a6.527



Sanford-Burnham-Prebys Medical Discovery Institute



Assay Description
The purified EphA proteins (EphA4-LBD, EphA3-LBD, and EphA2-LBD) were dissolved in 50 mM potassium phosphate buffer (pH 6.5) containing 100 mM NaCl. ...


Cell Chem Biol 24: 293-305 (2017)


Article DOI: 10.1016/j.chembiol.2017.01.006
BindingDB Entry DOI: 10.7270/Q2GX49FB
More data for this
Ligand-Target Pair
Ephrin type-A receptor 4 ligand binding domain (EphA4-LBD)


(Homo sapiens (Human))
BDBM223305
PNG
(123C2)
Show SMILES NCCCC(=O)N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccncc1)C(=O)NCCc1c[nH]c2ccccc12
Show InChI InChI=1S/C42H45ClN8O5/c43-30-9-7-26(8-10-30)20-37(51-42(56)38(49-39(53)6-3-16-44)22-29-25-48-35-12-11-31(52)23-33(29)35)41(55)50-36(21-27-13-17-45-18-14-27)40(54)46-19-15-28-24-47-34-5-2-1-4-32(28)34/h1-2,4-5,7-14,17-18,23-25,36-38,47-48,52H,3,6,15-16,19-22,44H2,(H,46,54)(H,49,53)(H,50,55)(H,51,56)/t36-,37-,38-/m0/s1
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n/an/an/a 1.10E+3n/an/an/a6.527



Sanford-Burnham-Prebys Medical Discovery Institute



Assay Description
The purified EphA proteins (EphA4-LBD, EphA3-LBD, and EphA2-LBD) were dissolved in 50 mM potassium phosphate buffer (pH 6.5) containing 100 mM NaCl. ...


Cell Chem Biol 24: 293-305 (2017)


Article DOI: 10.1016/j.chembiol.2017.01.006
BindingDB Entry DOI: 10.7270/Q2GX49FB
More data for this
Ligand-Target Pair
Ephrin type-A receptor 4 ligand binding domain (EphA4-LBD)


(Homo sapiens (Human))
BDBM223300
PNG
(EphA4-LBC inhibitor, Compound 22)
Show SMILES NCCC(=O)N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccncc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(N)=O
Show InChI InChI=1S/C42H44ClN9O6/c43-28-7-5-24(6-8-28)17-35(52-42(58)37(49-38(54)11-14-44)20-27-23-48-33-10-9-29(53)21-31(27)33)41(57)51-36(18-25-12-15-46-16-13-25)40(56)50-34(39(45)55)19-26-22-47-32-4-2-1-3-30(26)32/h1-10,12-13,15-16,21-23,34-37,47-48,53H,11,14,17-20,44H2,(H2,45,55)(H,49,54)(H,50,56)(H,51,57)(H,52,58)/t34-,35+,36+,37+/m1/s1
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n/an/an/a 1.20E+3n/an/an/a6.527



Sanford-Burnham-Prebys Medical Discovery Institute



Assay Description
The purified EphA proteins (EphA4-LBD, EphA3-LBD, and EphA2-LBD) were dissolved in 50 mM potassium phosphate buffer (pH 6.5) containing 100 mM NaCl. ...


Cell Chem Biol 24: 293-305 (2017)


Article DOI: 10.1016/j.chembiol.2017.01.006
BindingDB Entry DOI: 10.7270/Q2GX49FB
More data for this
Ligand-Target Pair
Ephrin type-A receptor 4 ligand binding domain (EphA4-LBD)


(Homo sapiens (Human))
BDBM223311
PNG
(123C4)
Show SMILES COc1ccc2[nH]cc(CCNC(=O)[C@H](Cc3ccncc3)NC(=O)[C@H](Cc3ccc(Cl)cc3)NC(=O)[C@H](Cc3c[nH]c4ccc(O)cc34)NC(=O)CCCN)c2c1
Show InChI InChI=1S/C43H47ClN8O6/c1-58-32-9-11-36-34(23-32)28(24-48-36)14-18-47-41(55)37(20-27-12-16-46-17-13-27)51-42(56)38(19-26-4-6-30(44)7-5-26)52-43(57)39(50-40(54)3-2-15-45)21-29-25-49-35-10-8-31(53)22-33(29)35/h4-13,16-17,22-25,37-39,48-49,53H,2-3,14-15,18-21,45H2,1H3,(H,47,55)(H,50,54)(H,51,56)(H,52,57)/t37-,38-,39-/m0/s1
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640n/an/an/an/an/an/an/an/a



Sanford-Burnham-Prebys Medical Discovery Institute



Assay Description
For competitive binding assays, 1 mL of 200 mM EphA4-LBD was pre-incubated with the tested compounds at various concentrations in 98 mL of PBS (pH 7....


Cell Chem Biol 24: 293-305 (2017)


Article DOI: 10.1016/j.chembiol.2017.01.006
BindingDB Entry DOI: 10.7270/Q2GX49FB
More data for this
Ligand-Target Pair
Ephrin type-A receptor 4 ligand binding domain (EphA4-LBD)


(Homo sapiens (Human))
BDBM223301
PNG
(120H10)
Show SMILES NCCCC(=O)N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccncc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(N)=O
Show InChI InChI=1S/C43H46ClN9O6/c44-29-9-7-25(8-10-29)18-36(53-43(59)38(50-39(55)6-3-15-45)21-28-24-49-34-12-11-30(54)22-32(28)34)42(58)52-37(19-26-13-16-47-17-14-26)41(57)51-35(40(46)56)20-27-23-48-33-5-2-1-4-31(27)33/h1-2,4-5,7-14,16-17,22-24,35-38,48-49,54H,3,6,15,18-21,45H2,(H2,46,56)(H,50,55)(H,51,57)(H,52,58)(H,53,59)/t35-,36+,37+,38+/m1/s1
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960n/an/an/an/an/an/an/an/a



Sanford-Burnham-Prebys Medical Discovery Institute



Assay Description
For competitive binding assays, 1 mL of 200 mM EphA4-LBD was pre-incubated with the tested compounds at various concentrations in 98 mL of PBS (pH 7....


Cell Chem Biol 24: 293-305 (2017)


Article DOI: 10.1016/j.chembiol.2017.01.006
BindingDB Entry DOI: 10.7270/Q2GX49FB
More data for this
Ligand-Target Pair
Ephrin type-A receptor 4 ligand binding domain (EphA4-LBD)


(Homo sapiens (Human))
BDBM223305
PNG
(123C2)
Show SMILES NCCCC(=O)N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccncc1)C(=O)NCCc1c[nH]c2ccccc12
Show InChI InChI=1S/C42H45ClN8O5/c43-30-9-7-26(8-10-30)20-37(51-42(56)38(49-39(53)6-3-16-44)22-29-25-48-35-12-11-31(52)23-33(29)35)41(55)50-36(21-27-13-17-45-18-14-27)40(54)46-19-15-28-24-47-34-5-2-1-4-32(28)34/h1-2,4-5,7-14,17-18,23-25,36-38,47-48,52H,3,6,15-16,19-22,44H2,(H,46,54)(H,49,53)(H,50,55)(H,51,56)/t36-,37-,38-/m0/s1
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1.59E+3n/an/an/an/an/an/an/an/a



Sanford-Burnham-Prebys Medical Discovery Institute



Assay Description
For competitive binding assays, 1 mL of 200 mM EphA4-LBD was pre-incubated with the tested compounds at various concentrations in 98 mL of PBS (pH 7....


Cell Chem Biol 24: 293-305 (2017)


Article DOI: 10.1016/j.chembiol.2017.01.006
BindingDB Entry DOI: 10.7270/Q2GX49FB
More data for this
Ligand-Target Pair
Ephrin type-A receptor 4 ligand binding domain (EphA4-LBD)


(Homo sapiens (Human))
BDBM223310
PNG
(123C7)
Show SMILES COc1ccc2c(CCNC(=O)[C@H](Cc3ccncc3)NC(=O)[C@H](Cc3ccc(Cl)cc3)NC(=O)[C@H](Cc3c[nH]c4ccc(O)cc34)NC(=O)CCCN)c[nH]c2c1
Show InChI InChI=1S/C43H47ClN8O6/c1-58-32-9-10-33-28(24-49-36(33)23-32)14-18-47-41(55)37(20-27-12-16-46-17-13-27)51-42(56)38(19-26-4-6-30(44)7-5-26)52-43(57)39(50-40(54)3-2-15-45)21-29-25-48-35-11-8-31(53)22-34(29)35/h4-13,16-17,22-25,37-39,48-49,53H,2-3,14-15,18-21,45H2,1H3,(H,47,55)(H,50,54)(H,51,56)(H,52,57)/t37-,38-,39-/m0/s1
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1.59E+3n/an/an/an/an/an/an/an/a



Sanford-Burnham-Prebys Medical Discovery Institute



Assay Description
For competitive binding assays, 1 mL of 200 mM EphA4-LBD was pre-incubated with the tested compounds at various concentrations in 98 mL of PBS (pH 7....


Cell Chem Biol 24: 293-305 (2017)


Article DOI: 10.1016/j.chembiol.2017.01.006
BindingDB Entry DOI: 10.7270/Q2GX49FB
More data for this
Ligand-Target Pair
Ephrin type-A receptor 4 ligand binding domain (EphA4-LBD)


(Homo sapiens (Human))
BDBM223300
PNG
(EphA4-LBC inhibitor, Compound 22)
Show SMILES NCCC(=O)N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccncc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(N)=O
Show InChI InChI=1S/C42H44ClN9O6/c43-28-7-5-24(6-8-28)17-35(52-42(58)37(49-38(54)11-14-44)20-27-23-48-33-10-9-29(53)21-31(27)33)41(57)51-36(18-25-12-15-46-16-13-25)40(56)50-34(39(45)55)19-26-22-47-32-4-2-1-3-30(26)32/h1-10,12-13,15-16,21-23,34-37,47-48,53H,11,14,17-20,44H2,(H2,45,55)(H,49,54)(H,50,56)(H,51,57)(H,52,58)/t34-,35+,36+,37+/m1/s1
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2.14E+3n/an/an/an/an/an/an/an/a



Sanford-Burnham-Prebys Medical Discovery Institute



Assay Description
For competitive binding assays, 1 mL of 200 mM EphA4-LBD was pre-incubated with the tested compounds at various concentrations in 98 mL of PBS (pH 7....


Cell Chem Biol 24: 293-305 (2017)


Article DOI: 10.1016/j.chembiol.2017.01.006
BindingDB Entry DOI: 10.7270/Q2GX49FB
More data for this
Ligand-Target Pair
Ephrin type-A receptor 4 ligand binding domain (EphA4-LBD)


(Homo sapiens (Human))
BDBM223307
PNG
(123C3)
Show SMILES NCCCC(=O)N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccncc1)C(=O)NCCc1c[nH]c2ccc(F)cc12
Show InChI InChI=1S/C42H44ClFN8O5/c43-29-5-3-25(4-6-29)18-37(52-42(57)38(50-39(54)2-1-14-45)20-28-24-49-35-10-8-31(53)22-33(28)35)41(56)51-36(19-26-11-15-46-16-12-26)40(55)47-17-13-27-23-48-34-9-7-30(44)21-32(27)34/h3-12,15-16,21-24,36-38,48-49,53H,1-2,13-14,17-20,45H2,(H,47,55)(H,50,54)(H,51,56)(H,52,57)/t36-,37-,38-/m0/s1
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2.22E+3n/an/an/an/an/an/an/an/a



Sanford-Burnham-Prebys Medical Discovery Institute



Assay Description
For competitive binding assays, 1 mL of 200 mM EphA4-LBD was pre-incubated with the tested compounds at various concentrations in 98 mL of PBS (pH 7....


Cell Chem Biol 24: 293-305 (2017)


Article DOI: 10.1016/j.chembiol.2017.01.006
BindingDB Entry DOI: 10.7270/Q2GX49FB
More data for this
Ligand-Target Pair
Ephrin type-A receptor 4 ligand binding domain (EphA4-LBD)


(Homo sapiens (Human))
BDBM223308
PNG
(123C5)
Show SMILES NCCCC(=O)N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccncc1)C(=O)NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C42H45ClN8O6/c43-29-5-3-25(4-6-29)18-37(51-42(57)38(49-39(54)2-1-14-44)20-28-24-48-35-10-8-31(53)22-33(28)35)41(56)50-36(19-26-11-15-45-16-12-26)40(55)46-17-13-27-23-47-34-9-7-30(52)21-32(27)34/h3-12,15-16,21-24,36-38,47-48,52-53H,1-2,13-14,17-20,44H2,(H,46,55)(H,49,54)(H,50,56)(H,51,57)/t36-,37-,38-/m0/s1
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2.57E+3n/an/an/an/an/an/an/an/a



Sanford-Burnham-Prebys Medical Discovery Institute



Assay Description
For competitive binding assays, 1 mL of 200 mM EphA4-LBD was pre-incubated with the tested compounds at various concentrations in 98 mL of PBS (pH 7....


Cell Chem Biol 24: 293-305 (2017)


Article DOI: 10.1016/j.chembiol.2017.01.006
BindingDB Entry DOI: 10.7270/Q2GX49FB
More data for this
Ligand-Target Pair
Ephrin type-A receptor 4 ligand binding domain (EphA4-LBD)


(Homo sapiens (Human))
BDBM223302
PNG
(123B1)
Show SMILES NCCCCC(=O)N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccncc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(N)=O
Show InChI InChI=1S/C44H48ClN9O6/c45-30-10-8-26(9-11-30)19-37(54-44(60)39(51-40(56)7-3-4-16-46)22-29-25-50-35-13-12-31(55)23-33(29)35)43(59)53-38(20-27-14-17-48-18-15-27)42(58)52-36(41(47)57)21-28-24-49-34-6-2-1-5-32(28)34/h1-2,5-6,8-15,17-18,23-25,36-39,49-50,55H,3-4,7,16,19-22,46H2,(H2,47,57)(H,51,56)(H,52,58)(H,53,59)(H,54,60)/t36-,37+,38+,39+/m1/s1
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3.04E+3n/an/an/an/an/an/an/an/a



Sanford-Burnham-Prebys Medical Discovery Institute



Assay Description
For competitive binding assays, 1 mL of 200 mM EphA4-LBD was pre-incubated with the tested compounds at various concentrations in 98 mL of PBS (pH 7....


Cell Chem Biol 24: 293-305 (2017)


Article DOI: 10.1016/j.chembiol.2017.01.006
BindingDB Entry DOI: 10.7270/Q2GX49FB
More data for this
Ligand-Target Pair
Ephrin type-A receptor 4 ligand binding domain (EphA4-LBD)


(Homo sapiens (Human))
BDBM223309
PNG
(123C6)
Show SMILES NCCCC(=O)N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccncc1)C(=O)NCCc1c[nH]c2ccc(Cl)cc12
Show InChI InChI=1S/C42H44Cl2N8O5/c43-29-5-3-25(4-6-29)18-37(52-42(57)38(50-39(54)2-1-14-45)20-28-24-49-35-10-8-31(53)22-33(28)35)41(56)51-36(19-26-11-15-46-16-12-26)40(55)47-17-13-27-23-48-34-9-7-30(44)21-32(27)34/h3-12,15-16,21-24,36-38,48-49,53H,1-2,13-14,17-20,45H2,(H,47,55)(H,50,54)(H,51,56)(H,52,57)/t36-,37-,38-/m0/s1
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3.14E+3n/an/an/an/an/an/an/an/a



Sanford-Burnham-Prebys Medical Discovery Institute



Assay Description
For competitive binding assays, 1 mL of 200 mM EphA4-LBD was pre-incubated with the tested compounds at various concentrations in 98 mL of PBS (pH 7....


Cell Chem Biol 24: 293-305 (2017)


Article DOI: 10.1016/j.chembiol.2017.01.006
BindingDB Entry DOI: 10.7270/Q2GX49FB
More data for this
Ligand-Target Pair
Ephrin type-A receptor 4 ligand binding domain (EphA4-LBD)


(Homo sapiens (Human))
BDBM223306
PNG
(123C12)
Show SMILES NCCCC(=O)N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccncc1)C(=O)NCCc1cccc2ccccc12
Show InChI InChI=1S/C44H46ClN7O5/c45-33-12-10-28(11-13-33)23-39(52-44(57)40(50-41(54)9-4-19-46)25-32-27-49-37-15-14-34(53)26-36(32)37)43(56)51-38(24-29-16-20-47-21-17-29)42(55)48-22-18-31-7-3-6-30-5-1-2-8-35(30)31/h1-3,5-8,10-17,20-21,26-27,38-40,49,53H,4,9,18-19,22-25,46H2,(H,48,55)(H,50,54)(H,51,56)(H,52,57)/t38-,39-,40-/m0/s1
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PC cid
PC sid
UniChem
Article
PubMed
7.67E+3n/an/an/an/an/an/an/an/a



Sanford-Burnham-Prebys Medical Discovery Institute



Assay Description
For competitive binding assays, 1 mL of 200 mM EphA4-LBD was pre-incubated with the tested compounds at various concentrations in 98 mL of PBS (pH 7....


Cell Chem Biol 24: 293-305 (2017)


Article DOI: 10.1016/j.chembiol.2017.01.006
BindingDB Entry DOI: 10.7270/Q2GX49FB
More data for this
Ligand-Target Pair
Ephrin type-A receptor 4 ligand binding domain (EphA4-LBD)


(Homo sapiens (Human))
BDBM223303
PNG
(120G1)
Show SMILES NCCC(=O)N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccncc1)C(=O)N[C@H](Cc1ccncc1)C(N)=O
Show InChI InChI=1S/C39H42ClN9O6/c40-27-3-1-23(2-4-27)18-32(49-39(55)34(46-35(51)7-12-41)20-26-22-45-30-6-5-28(50)21-29(26)30)38(54)48-33(19-25-10-15-44-16-11-25)37(53)47-31(36(42)52)17-24-8-13-43-14-9-24/h1-6,8-11,13-16,21-22,31-34,45,50H,7,12,17-20,41H2,(H2,42,52)(H,46,51)(H,47,53)(H,48,54)(H,49,55)/t31-,32+,33+,34+/m1/s1
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UniChem
Article
PubMed
1.40E+4n/an/an/an/an/an/an/an/a



Sanford-Burnham-Prebys Medical Discovery Institute



Assay Description
For competitive binding assays, 1 mL of 200 mM EphA4-LBD was pre-incubated with the tested compounds at various concentrations in 98 mL of PBS (pH 7....


Cell Chem Biol 24: 293-305 (2017)


Article DOI: 10.1016/j.chembiol.2017.01.006
BindingDB Entry DOI: 10.7270/Q2GX49FB
More data for this
Ligand-Target Pair
Ephrin type-A receptor 4 ligand binding domain (EphA4-LBD)


(Homo sapiens (Human))
BDBM223304
PNG
(120G2)
Show SMILES CC(C)(N)C(C)(C)C(=O)N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccncc1)C(=O)N[C@H](Cc1ccncc1)C(N)=O
Show InChI InChI=1S/C43H50ClN9O6/c1-42(2,43(3,4)46)41(59)53-36(22-28-24-49-32-10-9-30(54)23-31(28)32)40(58)52-34(20-25-5-7-29(44)8-6-25)39(57)51-35(21-27-13-17-48-18-14-27)38(56)50-33(37(45)55)19-26-11-15-47-16-12-26/h5-18,23-24,33-36,49,54H,19-22,46H2,1-4H3,(H2,45,55)(H,50,56)(H,51,57)(H,52,58)(H,53,59)/t33-,34+,35+,36+/m1/s1
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AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
1.00E+5n/an/an/an/an/an/an/an/a



Sanford-Burnham-Prebys Medical Discovery Institute



Assay Description
For competitive binding assays, 1 mL of 200 mM EphA4-LBD was pre-incubated with the tested compounds at various concentrations in 98 mL of PBS (pH 7....


Cell Chem Biol 24: 293-305 (2017)


Article DOI: 10.1016/j.chembiol.2017.01.006
BindingDB Entry DOI: 10.7270/Q2GX49FB
More data for this
Ligand-Target Pair