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Found 2566 hits Enz. Inhib. hit(s) with Target = 'Focal adhesion kinase 1/vascular endothelial growth factor receptor 3'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM21079
PNG
(1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
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n/an/an/a 1.60E+4n/an/an/a7.425



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q2NC5ZHH
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM21
PNG
(6-[(4R,5S,6S,7R)-4,7-dibenzyl-3-(5-carboxypentyl)-...)
Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)
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n/an/an/a 1.10E+6n/an/an/a7.425



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q2NC5ZHH
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM31085
PNG
(1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluorom...)
Show SMILES CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C26H30F3N7O2/c1-3-35-10-12-36(13-11-35)16-18-4-5-20(14-22(18)26(27,28)29)34-25(37)33-19-6-8-21(9-7-19)38-24-15-23(30-2)31-17-32-24/h4-9,14-15,17H,3,10-13,16H2,1-2H3,(H,30,31,32)(H2,33,34,37)
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n/an/an/a 1.20E+5n/an/an/a7.425



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q2NC5ZHH
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM13533
PNG
(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37)
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n/an/an/a 7.10E+6n/an/an/a7.425



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q2NC5ZHH
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM25118
PNG
((3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,...)
Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O
Show InChI InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29)
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n/an/an/a 5.80E+5n/an/an/a7.425



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q2NC5ZHH
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM31088
PNG
(1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-y...)
Show SMILES Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12
Show InChI InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34)
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n/an/an/a 2.00E+6n/an/an/a7.425



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q2NC5ZHH
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM5446
PNG
(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)
Show SMILES COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCOC
Show InChI InChI=1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25)
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n/an/an/a 2.10E+6n/an/an/a7.425



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q2NC5ZHH
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM26474
PNG
(5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino...)
Show SMILES CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(C)c(c2)S(N)(=O)=O)n1
Show InChI InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25)
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n/an/an/a 2.70E+4n/an/an/a7.425



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q2NC5ZHH
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM6866
PNG
(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Show SMILES Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)nn1C(=O)c1c(F)cccc1F
Show InChI InChI=1S/C15H12F2N6O3S/c16-10-2-1-3-11(17)12(10)13(24)23-14(18)21-15(22-23)20-8-4-6-9(7-5-8)27(19,25)26/h1-7H,(H2,19,25,26)(H3,18,20,21,22)
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n/an/an/a 1.10E+6n/an/an/a7.425



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q2NC5ZHH
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM31093
PNG
(4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-py...)
Show SMILES OC(=O)c1ccc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2F)cc1
Show InChI InChI=1S/C25H15ClF2N4O2/c26-15-6-9-17-18(10-15)23(21-19(27)2-1-3-20(21)28)29-11-14-12-30-25(32-22(14)17)31-16-7-4-13(5-8-16)24(33)34/h1-10,12H,11H2,(H,33,34)(H,30,31,32)
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n/an/an/a 3.10E+6n/an/an/a7.425



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q2NC5ZHH
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM31094
PNG
(PKC-412 | cid_24202429)
Show SMILES CO[C@H]1[C@H](C[C@@H]2O[C@@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1
Show InChI InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m0/s1
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n/an/an/a 6.70E+5n/an/an/a7.425



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q2NC5ZHH
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM4851
PNG
((4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-...)
Show SMILES Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1
Show InChI InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25)
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n/an/an/a 3.30E+5n/an/an/a7.425



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q2NC5ZHH
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM31095
PNG
(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Show SMILES Cc1[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1
Show InChI InChI=1S/C23H27FN4O4/c1-13-20(10-18-17-9-15(24)3-4-19(17)27-22(18)30)26-14(2)21(13)23(31)25-11-16(29)12-28-5-7-32-8-6-28/h3-4,9-10,16,26,29H,5-8,11-12H2,1-2H3,(H,25,31)(H,27,30)/b18-10-/t16-/m0/s1
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Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q2NC5ZHH
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM16673
PNG
(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)
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n/an/an/a 9.50E+4n/an/an/a7.425



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Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q2NC5ZHH
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM31096
PNG
(CHEMBL290084 | Staurosporine | cid_451705)
Show SMILES CN[C@H]1C[C@@H]2O[C@](C)([C@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m0/s1
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n/an/an/a 2.80E+4n/an/an/a7.425



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Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q2NC5ZHH
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM4814
PNG
(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Show SMILES CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C
Show InChI InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-
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n/an/an/a 5.00E+4n/an/an/a7.425



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Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q2NC5ZHH
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM13534
PNG
(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Show SMILES CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1
Show InChI InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29)
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n/an/an/a 1.90E+6n/an/an/a7.425



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q2NC5ZHH
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM24773
PNG
(AMG 706 | AMG-706 | Motesanib | N-(3,3-dimethyl-1,...)
Show SMILES CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12
Show InChI InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28)
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n/an/an/a 9.70E+3n/an/an/a7.425



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q2NC5ZHH
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126878
PNG
(US8785464, 37)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2cccc(F)c2C(C)=O)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C27H27F4N5O4/c1-15(37)23-19(28)5-4-6-21(23)40-25-18(27(29,30)31)14-32-26(35-25)34-20-8-7-16(13-22(20)39-3)24(38)33-17-9-11-36(2)12-10-17/h4-8,13-14,17H,9-12H2,1-3H3,(H,33,38)(H,32,34,35)
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n/an/a 139n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126879
PNG
(US8785464, 38)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2ccccc2-c2cc[nH]n2)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C28H28F3N7O3/c1-38-13-10-18(11-14-38)34-25(39)17-7-8-22(24(15-17)40-2)35-27-32-16-20(28(29,30)31)26(36-27)41-23-6-4-3-5-19(23)21-9-12-33-37-21/h3-9,12,15-16,18H,10-11,13-14H2,1-2H3,(H,33,37)(H,34,39)(H,32,35,36)
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n/an/a 81n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126880
PNG
(US8785464, 39)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2ccccc2-c2csnn2)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C27H26F3N7O3S/c1-37-11-9-17(10-12-37)32-24(38)16-7-8-20(23(13-16)39-2)33-26-31-14-19(27(28,29)30)25(34-26)40-22-6-4-3-5-18(22)21-15-41-36-35-21/h3-8,13-15,17H,9-12H2,1-2H3,(H,32,38)(H,31,33,34)
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n/an/a 12n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126881
PNG
(US8785464, 40)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2ccc(Br)cc2C#N)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C26H24BrF3N6O3/c1-36-9-7-18(8-10-36)33-23(37)15-3-5-20(22(12-15)38-2)34-25-32-14-19(26(28,29)30)24(35-25)39-21-6-4-17(27)11-16(21)13-31/h3-6,11-12,14,18H,7-10H2,1-2H3,(H,33,37)(H,32,34,35)
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n/an/a 30n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126882
PNG
(US8785464, 41)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2cc(Br)ccc2C#N)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C26H24BrF3N6O3/c1-36-9-7-18(8-10-36)33-23(37)15-4-6-20(22(11-15)38-2)34-25-32-14-19(26(28,29)30)24(35-25)39-21-12-17(27)5-3-16(21)13-31/h3-6,11-12,14,18H,7-10H2,1-2H3,(H,33,37)(H,32,34,35)
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n/an/a 30n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126883
PNG
(US8785464, 42)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2cccc(Cl)c2C#N)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C26H24ClF3N6O3/c1-36-10-8-16(9-11-36)33-23(37)15-6-7-20(22(12-15)38-2)34-25-32-14-18(26(28,29)30)24(35-25)39-21-5-3-4-19(27)17(21)13-31/h3-7,12,14,16H,8-11H2,1-2H3,(H,33,37)(H,32,34,35)
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n/an/a 8n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126884
PNG
(US8785464, 43)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2cccc(F)c2C#N)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C26H24F4N6O3/c1-36-10-8-16(9-11-36)33-23(37)15-6-7-20(22(12-15)38-2)34-25-32-14-18(26(28,29)30)24(35-25)39-21-5-3-4-19(27)17(21)13-31/h3-7,12,14,16H,8-11H2,1-2H3,(H,33,37)(H,32,34,35)
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n/an/a 31n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126885
PNG
(US8785464, 44)
Show SMILES COc1ccc(C#N)c(Oc2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2C(F)(F)F)c1
Show InChI InChI=1S/C27H27F3N6O4/c1-36-10-8-18(9-11-36)33-24(37)16-5-7-21(23(12-16)39-3)34-26-32-15-20(27(28,29)30)25(35-26)40-22-13-19(38-2)6-4-17(22)14-31/h4-7,12-13,15,18H,8-11H2,1-3H3,(H,33,37)(H,32,34,35)
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n/an/a 47n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126886
PNG
(US8785464, 45)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2ccc(Cl)cc2C#N)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C26H24ClF3N6O3/c1-36-9-7-18(8-10-36)33-23(37)15-3-5-20(22(12-15)38-2)34-25-32-14-19(26(28,29)30)24(35-25)39-21-6-4-17(27)11-16(21)13-31/h3-6,11-12,14,18H,7-10H2,1-2H3,(H,33,37)(H,32,34,35)
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n/an/a 20n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126887
PNG
(US8785464, 46)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2cccc3NC(=O)Cc23)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C27H27F3N6O4/c1-36-10-8-16(9-11-36)32-24(38)15-6-7-20(22(12-15)39-2)34-26-31-14-18(27(28,29)30)25(35-26)40-21-5-3-4-19-17(21)13-23(37)33-19/h3-7,12,14,16H,8-11,13H2,1-2H3,(H,32,38)(H,33,37)(H,31,34,35)
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n/an/a 69n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126888
PNG
(US8785464, 47)
Show SMILES COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc(c(Oc2cccc3NC(=O)Cc23)n1)C(F)(F)F
Show InChI InChI=1S/C27H26F4N6O4/c1-37-8-6-14(7-9-37)33-24(39)15-10-22(40-2)20(12-18(15)28)35-26-32-13-17(27(29,30)31)25(36-26)41-21-5-3-4-19-16(21)11-23(38)34-19/h3-5,10,12-14H,6-9,11H2,1-2H3,(H,33,39)(H,34,38)(H,32,35,36)
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n/an/a 150n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126889
PNG
(US8785464, 48)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2ccccc2C#N)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C26H25F3N6O3/c1-35-11-9-18(10-12-35)32-23(36)16-7-8-20(22(13-16)37-2)33-25-31-15-19(26(27,28)29)24(34-25)38-21-6-4-3-5-17(21)14-30/h3-8,13,15,18H,9-12H2,1-2H3,(H,32,36)(H,31,33,34)
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n/an/a 6n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126890
PNG
(US8785464, 49)
Show SMILES COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc(c(Oc2ccccc2C#N)n1)C(F)(F)F
Show InChI InChI=1S/C26H24F4N6O3/c1-36-9-7-16(8-10-36)33-23(37)17-11-22(38-2)20(12-19(17)27)34-25-32-14-18(26(28,29)30)24(35-25)39-21-6-4-3-5-15(21)13-31/h3-6,11-12,14,16H,7-10H2,1-2H3,(H,33,37)(H,32,34,35)
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n/an/a 7n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126891
PNG
(US8785464, 50)
Show SMILES COc1cc(ccc1Nc1ncc(c(Sc2ccccc2)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C25H26F3N5O2S/c1-33-12-10-17(11-13-33)30-22(34)16-8-9-20(21(14-16)35-2)31-24-29-15-19(25(26,27)28)23(32-24)36-18-6-4-3-5-7-18/h3-9,14-15,17H,10-13H2,1-2H3,(H,30,34)(H,29,31,32)
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n/an/a 64n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126892
PNG
(US8785464, 51)
Show SMILES COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc(c(Sc2ccccc2)n1)C(F)(F)F
Show InChI InChI=1S/C25H25F4N5O2S/c1-34-10-8-15(9-11-34)31-22(35)17-12-21(36-2)20(13-19(17)26)32-24-30-14-18(25(27,28)29)23(33-24)37-16-6-4-3-5-7-16/h3-7,12-15H,8-11H2,1-2H3,(H,31,35)(H,30,32,33)
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n/an/a 70n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126894
PNG
(US8785464, 53)
Show SMILES FC(F)(F)c1cnc(Nc2ccc(cc2)C(=O)NCc2ccccc2)nc1OCCN1CCCC1=O
Show InChI InChI=1S/C25H24F3N5O3/c26-25(27,28)20-16-30-24(32-23(20)36-14-13-33-12-4-7-21(33)34)31-19-10-8-18(9-11-19)22(35)29-15-17-5-2-1-3-6-17/h1-3,5-6,8-11,16H,4,7,12-15H2,(H,29,35)(H,30,31,32)
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n/an/a 7.85E+3n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126895
PNG
(US8785464, 54)
Show SMILES FC(F)(F)C(=O)NCCCOc1nc(Nc2ccc(cc2)C(=O)NCc2ccccc2)ncc1C(F)(F)F
Show InChI InChI=1S/C24H21F6N5O3/c25-23(26,27)18-14-33-22(35-20(18)38-12-4-11-31-21(37)24(28,29)30)34-17-9-7-16(8-10-17)19(36)32-13-15-5-2-1-3-6-15/h1-3,5-10,14H,4,11-13H2,(H,31,37)(H,32,36)(H,33,34,35)
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n/an/a 3.05E+3n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126896
PNG
(US8785464, 55)
Show SMILES CCCNC(=O)c1ccc(Nc2ncc(c(OCCCNC(=O)C(F)(F)F)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C20H21F6N5O3/c1-2-8-27-15(32)12-4-6-13(7-5-12)30-18-29-11-14(19(21,22)23)16(31-18)34-10-3-9-28-17(33)20(24,25)26/h4-7,11H,2-3,8-10H2,1H3,(H,27,32)(H,28,33)(H,29,30,31)
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n/an/a 3.30E+3n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126897
PNG
(US8785464, 56)
Show SMILES COc1cccc(COc2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2C(F)(F)F)c1
Show InChI InChI=1S/C27H30F3N5O4/c1-35-11-9-19(10-12-35)32-24(36)18-7-8-22(23(14-18)38-3)33-26-31-15-21(27(28,29)30)25(34-26)39-16-17-5-4-6-20(13-17)37-2/h4-8,13-15,19H,9-12,16H2,1-3H3,(H,32,36)(H,31,33,34)
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n/an/a 16n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126898
PNG
(US8785464, 57)
Show SMILES COc1cc(ccc1Nc1ncc(c(OCCN2CCCC2=O)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C25H31F3N6O4/c1-33-10-7-17(8-11-33)30-22(36)16-5-6-19(20(14-16)37-2)31-24-29-15-18(25(26,27)28)23(32-24)38-13-12-34-9-3-4-21(34)35/h5-6,14-15,17H,3-4,7-13H2,1-2H3,(H,30,36)(H,29,31,32)
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n/an/a 39n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126899
PNG
(US8785464, 58)
Show SMILES COc1cc(ccc1Nc1ncc(c(OCC2CCCO2)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C24H30F3N5O4/c1-32-9-7-16(8-10-32)29-21(33)15-5-6-19(20(12-15)34-2)30-23-28-13-18(24(25,26)27)22(31-23)36-14-17-4-3-11-35-17/h5-6,12-13,16-17H,3-4,7-11,14H2,1-2H3,(H,29,33)(H,28,30,31)
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n/an/a 15n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126900
PNG
(US8785464, 59)
Show SMILES COc1cc(ccc1Nc1ncc(c(OCC2CCCCN2C)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C26H35F3N6O3/c1-34-12-9-18(10-13-34)31-23(36)17-7-8-21(22(14-17)37-3)32-25-30-15-20(26(27,28)29)24(33-25)38-16-19-6-4-5-11-35(19)2/h7-8,14-15,18-19H,4-6,9-13,16H2,1-3H3,(H,31,36)(H,30,32,33)
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n/an/a 56n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126901
PNG
(US8785464, 60)
Show SMILES COc1cc(ccc1Nc1ncc(c(OC2CCCN(C)C2)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C25H33F3N6O3/c1-33-11-8-17(9-12-33)30-22(35)16-6-7-20(21(13-16)36-3)31-24-29-14-19(25(26,27)28)23(32-24)37-18-5-4-10-34(2)15-18/h6-7,13-14,17-18H,4-5,8-12,15H2,1-3H3,(H,30,35)(H,29,31,32)
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n/an/a 74n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126902
PNG
(US8785464, 61)
Show SMILES COc1ccc(OC)c(CCOc2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2C(F)(F)F)c1
Show InChI InChI=1S/C29H34F3N5O5/c1-37-12-9-20(10-13-37)34-26(38)19-5-7-23(25(16-19)41-4)35-28-33-17-22(29(30,31)32)27(36-28)42-14-11-18-15-21(39-2)6-8-24(18)40-3/h5-8,15-17,20H,9-14H2,1-4H3,(H,34,38)(H,33,35,36)
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n/an/a 104n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126903
PNG
(US8785464, 62)
Show SMILES COc1cc(ccc1Nc1ncc(c(OCc2cccc(OC)c2OC)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C28H32F3N5O5/c1-36-12-10-19(11-13-36)33-25(37)17-8-9-21(23(14-17)39-3)34-27-32-15-20(28(29,30)31)26(35-27)41-16-18-6-5-7-22(38-2)24(18)40-4/h5-9,14-15,19H,10-13,16H2,1-4H3,(H,33,37)(H,32,34,35)
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n/an/a 36n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126904
PNG
(US8785464, 63)
Show SMILES COc1cc(ccc1Nc1ncc(c(OCC2CCCCO2)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C25H32F3N5O4/c1-33-10-8-17(9-11-33)30-22(34)16-6-7-20(21(13-16)35-2)31-24-29-14-19(25(26,27)28)23(32-24)37-15-18-5-3-4-12-36-18/h6-7,13-14,17-18H,3-5,8-12,15H2,1-2H3,(H,30,34)(H,29,31,32)
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n/an/a 40n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126905
PNG
(US8785464, 64)
Show SMILES COc1cc(ccc1Nc1ncc(c(OCC2CCCCC2)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C26H34F3N5O3/c1-34-12-10-19(11-13-34)31-23(35)18-8-9-21(22(14-18)36-2)32-25-30-15-20(26(27,28)29)24(33-25)37-16-17-6-4-3-5-7-17/h8-9,14-15,17,19H,3-7,10-13,16H2,1-2H3,(H,31,35)(H,30,32,33)
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n/an/a 225n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126906
PNG
(US8785464, 65)
Show SMILES COC(=O)COc1nc(Nc2ccc(cc2OC)C(=O)NC2CCN(C)CC2)ncc1C(F)(F)F
Show InChI InChI=1S/C22H26F3N5O5/c1-30-8-6-14(7-9-30)27-19(32)13-4-5-16(17(10-13)33-2)28-21-26-11-15(22(23,24)25)20(29-21)35-12-18(31)34-3/h4-5,10-11,14H,6-9,12H2,1-3H3,(H,27,32)(H,26,28,29)
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n/an/a 61n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126907
PNG
(US8785464, 66)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2ccccc2-c2cncs2)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C28H27F3N6O3S/c1-37-11-9-18(10-12-37)34-25(38)17-7-8-21(23(13-17)39-2)35-27-33-14-20(28(29,30)31)26(36-27)40-22-6-4-3-5-19(22)24-15-32-16-41-24/h3-8,13-16,18H,9-12H2,1-2H3,(H,34,38)(H,33,35,36)
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n/an/a 222n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126908
PNG
(US8785464, 67)
Show SMILES COc1ncc(s1)-c1ccccc1Oc1nc(Nc2ccc(cc2OC)C(=O)NC2CCN(C)CC2)ncc1C(F)(F)F
Show InChI InChI=1S/C29H29F3N6O4S/c1-38-12-10-18(11-13-38)35-25(39)17-8-9-21(23(14-17)40-2)36-27-33-15-20(29(30,31)32)26(37-27)42-22-7-5-4-6-19(22)24-16-34-28(41-3)43-24/h4-9,14-16,18H,10-13H2,1-3H3,(H,35,39)(H,33,36,37)
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n/an/a 1.00E+4n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126909
PNG
(US8785464, 68)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2ccccc2-c2ccon2)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C28H27F3N6O4/c1-37-12-9-18(10-13-37)33-25(38)17-7-8-22(24(15-17)39-2)34-27-32-16-20(28(29,30)31)26(35-27)41-23-6-4-3-5-19(23)21-11-14-40-36-21/h3-8,11,14-16,18H,9-10,12-13H2,1-2H3,(H,33,38)(H,32,34,35)
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n/an/a 19n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126910
PNG
(US8785464, 69)
Show SMILES COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc(c(Oc2cc(C)ccc2C#N)n1)C(F)(F)F
Show InChI InChI=1S/C27H26F4N6O3/c1-15-4-5-16(13-32)22(10-15)40-25-19(27(29,30)31)14-33-26(36-25)35-21-12-20(28)18(11-23(21)39-3)24(38)34-17-6-8-37(2)9-7-17/h4-5,10-12,14,17H,6-9H2,1-3H3,(H,34,38)(H,33,35,36)
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n/an/a 161n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
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