BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 8927 hits Enz. Inhib. hit(s) with Target = 'Glycogen synthase kinase-3'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8336
PNG
(N-[5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-...)
Show SMILES O=C(Nc1n[nH]c2nnc(cc12)-c1cccnc1)C1CC1
Show InChI InChI=1S/C14H12N6O/c21-14(8-3-4-8)16-12-10-6-11(9-2-1-5-15-7-9)17-19-13(10)20-18-12/h1-2,5-8H,3-4H2,(H2,16,18,19,20,21)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.0800 -57.1n/an/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 1581-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00135-5
BindingDB Entry DOI: 10.7270/Q2BK19JV
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8337
PNG
(N-[5-(2,3-difluorophenyl)-1H-pyrazolo[3,4-c]pyrida...)
Show SMILES Fc1cccc(c1F)-c1cc2c(NC(=O)C3CCCC3)n[nH]c2nn1
Show InChI InChI=1S/C17H15F2N5O/c18-12-7-3-6-10(14(12)19)13-8-11-15(22-24-16(11)23-21-13)20-17(25)9-4-1-2-5-9/h3,6-9H,1-2,4-5H2,(H2,20,22,23,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.110 -56.3n/an/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 1581-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00135-5
BindingDB Entry DOI: 10.7270/Q2BK19JV
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8339
PNG
(N-[5-(2,3-difluorophenyl)-1H-pyrazolo[3,4-c]pyrida...)
Show SMILES CCN1CCC(CC(=O)Nc2n[nH]c3nnc(cc23)-c2cccc(F)c2F)CC1
Show InChI InChI=1S/C20H22F2N6O/c1-2-28-8-6-12(7-9-28)10-17(29)23-19-14-11-16(24-26-20(14)27-25-19)13-4-3-5-15(21)18(13)22/h3-5,11-12H,2,6-10H2,1H3,(H2,23,25,26,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.190 -54.9n/an/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 1581-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00135-5
BindingDB Entry DOI: 10.7270/Q2BK19JV
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8338
PNG
(N-[5-(2,3-difluorophenyl)-1H-pyrazolo[3,4-c]pyrida...)
Show SMILES CCN1CCC(CC1)C(=O)Nc1n[nH]c2nnc(cc12)-c1cccc(F)c1F
Show InChI InChI=1S/C19H20F2N6O/c1-2-27-8-6-11(7-9-27)19(28)22-17-13-10-15(23-25-18(13)26-24-17)12-4-3-5-14(20)16(12)21/h3-5,10-11H,2,6-9H2,1H3,(H2,22,24,25,26,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.950 -51.0n/an/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 1581-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00135-5
BindingDB Entry DOI: 10.7270/Q2BK19JV
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8296
PNG
(3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2ccc(Cl)cc2Cl)c2ccccc12
Show InChI InChI=1S/C19H12Cl2N2O2/c1-23-9-13(11-4-2-3-5-15(11)23)17-16(18(24)22-19(17)25)12-7-6-10(20)8-14(12)21/h2-9H,1H3,(H,22,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
9.10 -45.4 34.3n/an/an/an/a7.022



SmithKline Beecham Pharmaceuticals



Assay Description
In vitro kinase inhibition assay using purified GSK-3 alpha from insect cells, was incubated at room temperature with substrate, and test compounds i...


Chem Biol 7: 793-803 (2000)


Article DOI: 10.1021/jm701185v
BindingDB Entry DOI: 10.7270/Q2M32T0X
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8297
PNG
(3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-nitrophen...)
Show SMILES Oc1ccc(NC2=C(C(=O)NC2=O)c2ccccc2N(=O)=O)cc1Cl
Show InChI InChI=1S/C16H10ClN3O5/c17-10-7-8(5-6-12(10)21)18-14-13(15(22)19-16(14)23)9-3-1-2-4-11(9)20(24)25/h1-7,21H,(H2,18,19,22,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
30.8 -42.4 77.5n/an/an/an/a7.022



SmithKline Beecham Pharmaceuticals



Assay Description
In vitro kinase inhibition assay using purified GSK-3 alpha from insect cells, was incubated at room temperature with substrate, and test compounds i...


Chem Biol 7: 793-803 (2000)


Article DOI: 10.1021/jm701185v
BindingDB Entry DOI: 10.7270/Q2M32T0X
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8301
PNG
(4-phenyl-1H-pyrazolo[3,4-b]pyridin-3-amine | pyraz...)
Show SMILES Nc1n[nH]c2nccc(-c3ccccc3)c12
Show InChI InChI=1S/C12H10N4/c13-11-10-9(8-4-2-1-3-5-8)6-7-14-12(10)16-15-11/h1-7H,(H3,13,14,15,16)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/a>5.00E+3n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 1577-80 (2003)


Article DOI: 10.1016/s0960-894x(03)00134-3
BindingDB Entry DOI: 10.7270/Q2GB228K
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8302
PNG
(5-phenyl-1H-pyrazolo[3,4-c]pyridin-3-amine | pyraz...)
Show SMILES Nc1n[nH]c2cnc(cc12)-c1ccccc1
Show InChI InChI=1S/C12H10N4/c13-12-9-6-10(8-4-2-1-3-5-8)14-7-11(9)15-16-12/h1-7H,(H3,13,15,16)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.26E+3n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 1577-80 (2003)


Article DOI: 10.1016/s0960-894x(03)00134-3
BindingDB Entry DOI: 10.7270/Q2GB228K
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8303
PNG
(1-methyl-5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-amin...)
Show SMILES Cn1nc(N)c2cc(cnc12)-c1ccccc1
Show InChI InChI=1S/C13H12N4/c1-17-13-11(12(14)16-17)7-10(8-15-13)9-5-3-2-4-6-9/h2-8H,1H3,(H2,14,16)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+3n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 1577-80 (2003)


Article DOI: 10.1016/s0960-894x(03)00134-3
BindingDB Entry DOI: 10.7270/Q2GB228K
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8304
PNG
(5-phenylpyrido[3,2-d][1,2]oxazol-3-amine | isoxazo...)
Show SMILES Nc1noc2ncc(cc12)-c1ccccc1
Show InChI InChI=1S/C12H9N3O/c13-11-10-6-9(7-14-12(10)16-15-11)8-4-2-1-3-5-8/h1-7H,(H2,13,15)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>5.00E+3n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 1577-80 (2003)


Article DOI: 10.1016/s0960-894x(03)00134-3
BindingDB Entry DOI: 10.7270/Q2GB228K
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8305
PNG
(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-amine | pyrrol...)
Show SMILES Nc1c[nH]c2ncc(cc12)-c1ccccc1
Show InChI InChI=1S/C13H11N3/c14-12-8-16-13-11(12)6-10(7-15-13)9-4-2-1-3-5-9/h1-8H,14H2,(H,15,16)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/a>5.00E+3n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 1577-80 (2003)


Article DOI: 10.1016/s0960-894x(03)00134-3
BindingDB Entry DOI: 10.7270/Q2GB228K
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8306
PNG
(N-{5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl}acetami...)
Show SMILES CC(=O)Nc1n[nH]c2ncc(cc12)-c1ccccc1
Show InChI InChI=1S/C14H12N4O/c1-9(19)16-14-12-7-11(8-15-13(12)17-18-14)10-5-3-2-4-6-10/h2-8H,1H3,(H2,15,16,17,18,19)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 291n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 1577-80 (2003)


Article DOI: 10.1016/s0960-894x(03)00134-3
BindingDB Entry DOI: 10.7270/Q2GB228K
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8307
PNG
(N-{5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl}propana...)
Show SMILES CCC(=O)Nc1n[nH]c2ncc(cc12)-c1ccccc1
Show InChI InChI=1S/C15H14N4O/c1-2-13(20)17-15-12-8-11(9-16-14(12)18-19-15)10-6-4-3-5-7-10/h3-9H,2H2,1H3,(H2,16,17,18,19,20)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 43n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 1577-80 (2003)


Article DOI: 10.1016/s0960-894x(03)00134-3
BindingDB Entry DOI: 10.7270/Q2GB228K
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8308
PNG
(N-{5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl}butanam...)
Show SMILES CCCC(=O)Nc1n[nH]c2ncc(cc12)-c1ccccc1
Show InChI InChI=1S/C16H16N4O/c1-2-6-14(21)18-16-13-9-12(10-17-15(13)19-20-16)11-7-4-3-5-8-11/h3-5,7-10H,2,6H2,1H3,(H2,17,18,19,20,21)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 56n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 1577-80 (2003)


Article DOI: 10.1016/s0960-894x(03)00134-3
BindingDB Entry DOI: 10.7270/Q2GB228K
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8309
PNG
(2-methyl-N-{5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-y...)
Show SMILES CC(C)C(=O)Nc1n[nH]c2ncc(cc12)-c1ccccc1
Show InChI InChI=1S/C16H16N4O/c1-10(2)16(21)18-15-13-8-12(9-17-14(13)19-20-15)11-6-4-3-5-7-11/h3-10H,1-2H3,(H2,17,18,19,20,21)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 19n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 1577-80 (2003)


Article DOI: 10.1016/s0960-894x(03)00134-3
BindingDB Entry DOI: 10.7270/Q2GB228K
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8310
PNG
(N-{5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl}cyclope...)
Show SMILES O=C(Nc1n[nH]c2ncc(cc12)-c1ccccc1)C1CCCC1
Show InChI InChI=1S/C18H18N4O/c23-18(13-8-4-5-9-13)20-17-15-10-14(11-19-16(15)21-22-17)12-6-2-1-3-7-12/h1-3,6-7,10-11,13H,4-5,8-9H2,(H2,19,20,21,22,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 1577-80 (2003)


Article DOI: 10.1016/s0960-894x(03)00134-3
BindingDB Entry DOI: 10.7270/Q2GB228K
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8311
PNG
(3-ethyl-1-{5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl...)
Show SMILES CCNC(=O)Nc1n[nH]c2ncc(cc12)-c1ccccc1
Show InChI InChI=1S/C15H15N5O/c1-2-16-15(21)18-14-12-8-11(9-17-13(12)19-20-14)10-6-4-3-5-7-10/h3-9H,2H2,1H3,(H3,16,17,18,19,20,21)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.81E+3n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 1577-80 (2003)


Article DOI: 10.1016/s0960-894x(03)00134-3
BindingDB Entry DOI: 10.7270/Q2GB228K
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8312
PNG
(N-{5-phenyl-1H-pyrazolo[3,4-b]pyridin-3-yl}methane...)
Show SMILES CS(=O)(=O)Nc1n[nH]c2ncc(cc12)-c1ccccc1
Show InChI InChI=1S/C13H12N4O2S/c1-20(18,19)17-13-11-7-10(8-14-12(11)15-16-13)9-5-3-2-4-6-9/h2-8H,1H3,(H2,14,15,16,17)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.57E+3n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 1577-80 (2003)


Article DOI: 10.1016/s0960-894x(03)00134-3
BindingDB Entry DOI: 10.7270/Q2GB228K
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8313
PNG
(N-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)...)
Show SMILES CCCC(=O)Nc1n[nH]c2ncc(cc12)B1OC(C)(C)C(C)(C)O1
Show InChI InChI=1S/C16H23BN4O3/c1-6-7-12(22)19-14-11-8-10(9-18-13(11)20-21-14)17-23-15(2,3)16(4,5)24-17/h8-9H,6-7H2,1-5H3,(H2,18,19,20,21,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 356n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 1577-80 (2003)


Article DOI: 10.1016/s0960-894x(03)00134-3
BindingDB Entry DOI: 10.7270/Q2GB228K
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8314
PNG
(N-{1H-pyrazolo[3,4-b]pyridin-3-yl}butanamide | pyr...)
Show SMILES CCCC(=O)Nc1n[nH]c2ncccc12
Show InChI InChI=1S/C10H12N4O/c1-2-4-8(15)12-10-7-5-3-6-11-9(7)13-14-10/h3,5-6H,2,4H2,1H3,(H2,11,12,13,14,15)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.34E+3n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 1577-80 (2003)


Article DOI: 10.1016/s0960-894x(03)00134-3
BindingDB Entry DOI: 10.7270/Q2GB228K
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8330
PNG
(N-{5-phenyl-1H-pyrazolo[3,4-c]pyridazin-3-yl}butan...)
Show SMILES CCCC(=O)Nc1n[nH]c2nnc(cc12)-c1ccccc1
Show InChI InChI=1S/C15H15N5O/c1-2-6-13(21)16-14-11-9-12(10-7-4-3-5-8-10)17-19-15(11)20-18-14/h3-5,7-9H,2,6H2,1H3,(H2,16,18,19,20,21)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 1581-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00135-5
BindingDB Entry DOI: 10.7270/Q2BK19JV
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8331
PNG
(4-(4-ethylpiperazin-1-yl)-N-{5-phenyl-1H-pyrazolo[...)
Show SMILES CCN1CCN(CCCC(=O)Nc2n[nH]c3nnc(cc23)-c2ccccc2)CC1
Show InChI InChI=1S/C21H27N7O/c1-2-27-11-13-28(14-12-27)10-6-9-19(29)22-20-17-15-18(16-7-4-3-5-8-16)23-25-21(17)26-24-20/h3-5,7-8,15H,2,6,9-14H2,1H3,(H2,22,24,25,26,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 1581-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00135-5
BindingDB Entry DOI: 10.7270/Q2BK19JV
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8332
PNG
(4-(morpholin-4-yl)-N-{5-phenyl-1H-pyrazolo[3,4-c]p...)
Show SMILES O=C(CCCN1CCOCC1)Nc1n[nH]c2nnc(cc12)-c1ccccc1
Show InChI InChI=1S/C19H22N6O2/c26-17(7-4-8-25-9-11-27-12-10-25)20-18-15-13-16(14-5-2-1-3-6-14)21-23-19(15)24-22-18/h1-3,5-6,13H,4,7-12H2,(H2,20,22,23,24,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 1581-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00135-5
BindingDB Entry DOI: 10.7270/Q2BK19JV
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8333
PNG
(1-methyl-N-{5-phenyl-1H-pyrazolo[3,4-c]pyridazin-3...)
Show SMILES CN1CCC(CC1)C(=O)Nc1n[nH]c2nnc(cc12)-c1ccccc1
Show InChI InChI=1S/C18H20N6O/c1-24-9-7-13(8-10-24)18(25)19-16-14-11-15(12-5-3-2-4-6-12)20-22-17(14)23-21-16/h2-6,11,13H,7-10H2,1H3,(H2,19,21,22,23,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 9n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 1581-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00135-5
BindingDB Entry DOI: 10.7270/Q2BK19JV
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8334
PNG
(5-(4-ethylpiperazin-1-yl)-N-{5-phenyl-1H-pyrazolo[...)
Show SMILES CCN1CCN(CCCCC(=O)Nc2n[nH]c3nnc(cc23)-c2ccccc2)CC1
Show InChI InChI=1S/C22H29N7O/c1-2-28-12-14-29(15-13-28)11-7-6-10-20(30)23-21-18-16-19(17-8-4-3-5-9-17)24-26-22(18)27-25-21/h3-5,8-9,16H,2,6-7,10-15H2,1H3,(H2,23,25,26,27,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 1581-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00135-5
BindingDB Entry DOI: 10.7270/Q2BK19JV
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8335
PNG
(N-[5-(2,3-difluorophenyl)-1H-pyrazolo[3,4-c]pyrida...)
Show SMILES CN(C)CCCC(=O)Nc1n[nH]c2nnc(cc12)-c1cccc(F)c1F
Show InChI InChI=1S/C17H18F2N6O/c1-25(2)8-4-7-14(26)20-16-11-9-13(21-23-17(11)24-22-16)10-5-3-6-12(18)15(10)19/h3,5-6,9H,4,7-8H2,1-2H3,(H2,20,22,23,24,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 1581-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00135-5
BindingDB Entry DOI: 10.7270/Q2BK19JV
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8340
PNG
(6-aryl-pyrazolo[3,4-b]pyridine analogue 4 | N-{6-p...)
Show SMILES O=C(Nc1n[nH]c2nc(ccc12)-c1ccccc1)C1CC1
Show InChI InChI=1S/C16H14N4O/c21-16(11-6-7-11)18-15-12-8-9-13(17-14(12)19-20-15)10-4-2-1-3-5-10/h1-5,8-9,11H,6-7H2,(H2,17,18,19,20,21)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 425n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 3055-7 (2003)


Article DOI: 10.1016/s0960-894x(03)00645-0
BindingDB Entry DOI: 10.7270/Q26T0JVK
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8541
PNG
(N-[2-(2-fluorophenyl)ethyl]-2-[4-({[5-(pyridin-4-y...)
Show SMILES Fc1ccccc1CCNC(=O)Cc1ccc(CSc2nnc(o2)-c2ccncc2)cc1
Show InChI InChI=1S/C24H21FN4O2S/c25-21-4-2-1-3-19(21)11-14-27-22(30)15-17-5-7-18(8-6-17)16-32-24-29-28-23(31-24)20-9-12-26-13-10-20/h1-10,12-13H,11,14-16H2,(H,27,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.20E+3n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8542
PNG
(2-[4-({[5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl]sul...)
Show SMILES OC(=O)Cc1ccc(CSc2nnc(s2)-c2ccncc2)cc1
Show InChI InChI=1S/C16H13N3O2S2/c20-14(21)9-11-1-3-12(4-2-11)10-22-16-19-18-15(23-16)13-5-7-17-8-6-13/h1-8H,9-10H2,(H,20,21)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.10E+4n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8543
PNG
(2-[4-({[5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl]sulf...)
Show SMILES OC(=O)Cc1ccc(CSc2nnc(o2)-c2ccncc2)cc1
Show InChI InChI=1S/C16H13N3O3S/c20-14(21)9-11-1-3-12(4-2-11)10-23-16-19-18-15(22-16)13-5-7-17-8-6-13/h1-8H,9-10H2,(H,20,21)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.00E+3n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8544
PNG
(2-[4-({[5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl]sul...)
Show SMILES OC(=O)Cc1ccc(CSc2nnc([nH]2)-c2ccncc2)cc1
Show InChI InChI=1S/C16H14N4O2S/c21-14(22)9-11-1-3-12(4-2-11)10-23-16-18-15(19-20-16)13-5-7-17-8-6-13/h1-8H,9-10H2,(H,21,22)(H,18,19,20)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>2.50E+5n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8545
PNG
(2-[4-({[5-(pyridin-3-yl)-1,3,4-thiadiazol-2-yl]sul...)
Show SMILES OC(=O)Cc1ccc(CSc2nnc(s2)-c2cccnc2)cc1
Show InChI InChI=1S/C16H13N3O2S2/c20-14(21)8-11-3-5-12(6-4-11)10-22-16-19-18-15(23-16)13-2-1-7-17-9-13/h1-7,9H,8,10H2,(H,20,21)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>2.50E+5n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8546
PNG
(2-[4-({[5-(pyridin-2-yl)-1,3,4-thiadiazol-2-yl]sul...)
Show SMILES OC(=O)Cc1ccc(CSc2nnc(s2)-c2ccccn2)cc1
Show InChI InChI=1S/C16H13N3O2S2/c20-14(21)9-11-4-6-12(7-5-11)10-22-16-19-18-15(23-16)13-3-1-2-8-17-13/h1-8H,9-10H2,(H,20,21)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>2.50E+5n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8547
PNG
(4-({[5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl]sulfany...)
Show SMILES OC(=O)c1ccc(CSc2nnc(o2)-c2ccncc2)cc1
Show InChI InChI=1S/C15H11N3O3S/c19-14(20)12-3-1-10(2-4-12)9-22-15-18-17-13(21-15)11-5-7-16-8-6-11/h1-8H,9H2,(H,19,20)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.90E+4n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8548
PNG
(2-(benzylsulfanyl)-5-(pyridin-4-yl)-1,3,4-oxadiazo...)
Show SMILES C(Sc1nnc(o1)-c1ccncc1)c1ccccc1
Show InChI InChI=1S/C14H11N3OS/c1-2-4-11(5-3-1)10-19-14-17-16-13(18-14)12-6-8-15-9-7-12/h1-9H,10H2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 6.70E+3n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8549
PNG
(2-[(2-phenylethyl)sulfanyl]-5-(pyridin-4-yl)-1,3,4...)
Show SMILES C(Cc1ccccc1)Sc1nnc(o1)-c1ccncc1
Show InChI InChI=1S/C15H13N3OS/c1-2-4-12(5-3-1)8-11-20-15-18-17-14(19-15)13-6-9-16-10-7-13/h1-7,9-10H,8,11H2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.90E+4n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8550
PNG
(2-{[(3-chlorophenyl)methyl]sulfanyl}-5-(pyridin-4-...)
Show SMILES Clc1cccc(CSc2nnc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C14H10ClN3OS/c15-12-3-1-2-10(8-12)9-20-14-18-17-13(19-14)11-4-6-16-7-5-11/h1-8H,9H2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 820n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8551
PNG
(2-{[(2-chlorophenyl)methyl]sulfanyl}-5-(pyridin-4-...)
Show SMILES Clc1ccccc1CSc1nnc(o1)-c1ccncc1
Show InChI InChI=1S/C14H10ClN3OS/c15-12-4-2-1-3-11(12)9-20-14-18-17-13(19-14)10-5-7-16-8-6-10/h1-8H,9H2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.20E+4n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8552
PNG
(2-{[(3-iodophenyl)methyl]sulfanyl}-5-(pyridin-4-yl...)
Show SMILES Ic1cccc(CSc2nnc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C14H10IN3OS/c15-12-3-1-2-10(8-12)9-20-14-18-17-13(19-14)11-4-6-16-7-5-11/h1-8H,9H2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 390n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8553
PNG
(2-{[(4-iodophenyl)methyl]sulfanyl}-5-(pyridin-4-yl...)
Show SMILES Ic1ccc(CSc2nnc(o2)-c2ccncc2)cc1
Show InChI InChI=1S/C14H10IN3OS/c15-12-3-1-10(2-4-12)9-20-14-18-17-13(19-14)11-5-7-16-8-6-11/h1-8H,9H2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.98E+5n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8554
PNG
(2-{[(3-fluorophenyl)methyl]sulfanyl}-5-(pyridin-4-...)
Show SMILES Fc1cccc(CSc2nnc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C14H10FN3OS/c15-12-3-1-2-10(8-12)9-20-14-18-17-13(19-14)11-4-6-16-7-5-11/h1-8H,9H2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.40E+3n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8555
PNG
(methyl 3-({[5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl]...)
Show SMILES COC(=O)c1cccc(CSc2nnc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C16H13N3O3S/c1-21-15(20)13-4-2-3-11(9-13)10-23-16-19-18-14(22-16)12-5-7-17-8-6-12/h2-9H,10H2,1H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.10E+3n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8556
PNG
(3-({[5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl]sulfany...)
Show SMILES OC(=O)c1cccc(CSc2nnc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C15H11N3O3S/c19-14(20)12-3-1-2-10(8-12)9-22-15-18-17-13(21-15)11-4-6-16-7-5-11/h1-8H,9H2,(H,19,20)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.35E+5n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8557
PNG
(2-({[3-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]methy...)
Show SMILES Cc1nc(no1)-c1cccc(CSc2nnc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C17H13N5O2S/c1-11-19-15(22-24-11)14-4-2-3-12(9-14)10-25-17-21-20-16(23-17)13-5-7-18-8-6-13/h2-9H,10H2,1H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>2.50E+5n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8341
PNG
(6-aryl-pyrazolo[3,4-b]pyridine analogue 5 | N-[6-(...)
Show SMILES Oc1ccc(cc1)-c1ccc2c(NC(=O)C3CC3)n[nH]c2n1
Show InChI InChI=1S/C16H14N4O2/c21-11-5-3-9(4-6-11)13-8-7-12-14(17-13)19-20-15(12)18-16(22)10-1-2-10/h3-8,10,21H,1-2H2,(H2,17,18,19,20,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 3055-7 (2003)


Article DOI: 10.1016/s0960-894x(03)00645-0
BindingDB Entry DOI: 10.7270/Q26T0JVK
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8342
PNG
(6-aryl-pyrazolo[3,4-b]pyridine analogue 6 | N-[6-(...)
Show SMILES COc1ccc(cc1)-c1ccc2c(NC(=O)C3CC3)n[nH]c2n1
Show InChI InChI=1S/C17H16N4O2/c1-23-12-6-4-10(5-7-12)14-9-8-13-15(18-14)20-21-16(13)19-17(22)11-2-3-11/h4-9,11H,2-3H2,1H3,(H2,18,19,20,21,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+3n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 3055-7 (2003)


Article DOI: 10.1016/s0960-894x(03)00645-0
BindingDB Entry DOI: 10.7270/Q26T0JVK
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8343
PNG
(6-aryl-pyrazolo[3,4-b]pyridine analogue 7 | N-[6-(...)
Show SMILES Oc1ccc(cc1O)-c1ccc2c(NC(=O)C3CC3)n[nH]c2n1
Show InChI InChI=1S/C16H14N4O3/c21-12-6-3-9(7-13(12)22)11-5-4-10-14(17-11)19-20-15(10)18-16(23)8-1-2-8/h3-8,21-22H,1-2H2,(H2,17,18,19,20,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 3055-7 (2003)


Article DOI: 10.1016/s0960-894x(03)00645-0
BindingDB Entry DOI: 10.7270/Q26T0JVK
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8344
PNG
(6-aryl-pyrazolo[3,4-b]pyridine analogue 8 | CHEMBL...)
Show SMILES Oc1cccc(c1)-c1ccc2c(NC(=O)C3CC3)n[nH]c2n1
Show InChI InChI=1S/C16H14N4O2/c21-11-3-1-2-10(8-11)13-7-6-12-14(17-13)19-20-15(12)18-16(22)9-4-5-9/h1-3,6-9,21H,4-5H2,(H2,17,18,19,20,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 12n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 3055-7 (2003)


Article DOI: 10.1016/s0960-894x(03)00645-0
BindingDB Entry DOI: 10.7270/Q26T0JVK
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8345
PNG
(6-aryl-pyrazolo[3,4-b]pyridine analogue 9 | N-[6-(...)
Show SMILES COc1cccc(c1)-c1ccc2c(NC(=O)C3CC3)n[nH]c2n1
Show InChI InChI=1S/C17H16N4O2/c1-23-12-4-2-3-11(9-12)14-8-7-13-15(18-14)20-21-16(13)19-17(22)10-5-6-10/h2-4,7-10H,5-6H2,1H3,(H2,18,19,20,21,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 125n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 3055-7 (2003)


Article DOI: 10.1016/s0960-894x(03)00645-0
BindingDB Entry DOI: 10.7270/Q26T0JVK
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8346
PNG
(6-aryl-pyrazolo[3,4-b]pyridine analogue 10 | N-[6-...)
Show SMILES Oc1ccccc1-c1ccc2c(NC(=O)C3CC3)n[nH]c2n1
Show InChI InChI=1S/C16H14N4O2/c21-13-4-2-1-3-10(13)12-8-7-11-14(17-12)19-20-15(11)18-16(22)9-5-6-9/h1-4,7-9,21H,5-6H2,(H2,17,18,19,20,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 36n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 3055-7 (2003)


Article DOI: 10.1016/s0960-894x(03)00645-0
BindingDB Entry DOI: 10.7270/Q26T0JVK
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 8927 total )  |  Next  |  Last  >>
Jump to: