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Compile Data Set for Download or QSAR

Found 1140 hits Enz. Inhib. hit(s) with Target = 'HSP90 and hnRNPA2/B1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20761
PNG
(9-butyl-8-[(7-methyl-1,3-benzothiazol-2-yl)sulfany...)
Show SMILES CCCCn1c(Sc2nc3cccc(C)c3s2)nc2c(N)ncnc12
Show InChI InChI=1S/C17H18N6S2/c1-3-4-8-23-15-12(14(18)19-9-20-15)22-16(23)25-17-21-11-7-5-6-10(2)13(11)24-17/h5-7,9H,3-4,8H2,1-2H3,(H2,18,19,20)
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n/an/an/an/a 300n/an/a7.237



Conforma Therapeutics Corporation



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 49: 5352-62 (2006)


Article DOI: 10.1021/jm051146h
BindingDB Entry DOI: 10.7270/Q26M354P
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20760
PNG
(9-butyl-8-[(7-fluoro-1,3-benzothiazol-2-yl)sulfany...)
Show SMILES CCCCn1c(Sc2nc3cccc(F)c3s2)nc2c(N)ncnc12
Show InChI InChI=1S/C16H15FN6S2/c1-2-3-7-23-14-11(13(18)19-8-20-14)22-15(23)25-16-21-10-6-4-5-9(17)12(10)24-16/h4-6,8H,2-3,7H2,1H3,(H2,18,19,20)
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n/an/an/an/a 200n/an/a7.237



Conforma Therapeutics Corporation



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 49: 5352-62 (2006)


Article DOI: 10.1021/jm051146h
BindingDB Entry DOI: 10.7270/Q26M354P
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20763
PNG
(9-butyl-8-[(7-methoxy-1,3-benzothiazol-2-yl)sulfan...)
Show SMILES CCCCn1c(Sc2nc3cccc(OC)c3s2)nc2c(N)ncnc12
Show InChI InChI=1S/C17H18N6OS2/c1-3-4-8-23-15-12(14(18)19-9-20-15)22-16(23)26-17-21-10-6-5-7-11(24-2)13(10)25-17/h5-7,9H,3-4,8H2,1-2H3,(H2,18,19,20)
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n/an/an/an/a 190n/an/a7.237



Conforma Therapeutics Corporation



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 49: 5352-62 (2006)


Article DOI: 10.1021/jm051146h
BindingDB Entry DOI: 10.7270/Q26M354P
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20764
PNG
(9-butyl-8-[(7-ethoxy-1,3-benzothiazol-2-yl)sulfany...)
Show SMILES CCCCn1c(Sc2nc3cccc(OCC)c3s2)nc2c(N)ncnc12
Show InChI InChI=1S/C18H20N6OS2/c1-3-5-9-24-16-13(15(19)20-10-21-16)23-17(24)27-18-22-11-7-6-8-12(25-4-2)14(11)26-18/h6-8,10H,3-5,9H2,1-2H3,(H2,19,20,21)
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n/an/an/an/a 1.00E+5n/an/a7.237



Conforma Therapeutics Corporation



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 49: 5352-62 (2006)


Article DOI: 10.1021/jm051146h
BindingDB Entry DOI: 10.7270/Q26M354P
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20765
PNG
(8-[(7-chloro-1,3-benzothiazol-2-yl)sulfanyl]-9-eth...)
Show SMILES CCn1c(Sc2nc3cccc(Cl)c3s2)nc2c(N)ncnc12
Show InChI InChI=1S/C14H11ClN6S2/c1-2-21-12-9(11(16)17-6-18-12)20-13(21)23-14-19-8-5-3-4-7(15)10(8)22-14/h3-6H,2H2,1H3,(H2,16,17,18)
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n/an/an/an/a 200n/an/a7.237



Conforma Therapeutics Corporation



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 49: 5352-62 (2006)


Article DOI: 10.1021/jm051146h
BindingDB Entry DOI: 10.7270/Q26M354P
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20766
PNG
(8-[(7-chloro-1,3-benzothiazol-2-yl)sulfanyl]-9-pro...)
Show SMILES CCCn1c(Sc2nc3cccc(Cl)c3s2)nc2c(N)ncnc12
Show InChI InChI=1S/C15H13ClN6S2/c1-2-6-22-13-10(12(17)18-7-19-13)21-14(22)24-15-20-9-5-3-4-8(16)11(9)23-15/h3-5,7H,2,6H2,1H3,(H2,17,18,19)
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n/an/an/an/a 250n/an/a7.237



Conforma Therapeutics Corporation



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 49: 5352-62 (2006)


Article DOI: 10.1021/jm051146h
BindingDB Entry DOI: 10.7270/Q26M354P
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20767
PNG
(8-[(7-chloro-1,3-benzothiazol-2-yl)sulfanyl]-9-pen...)
Show SMILES CCCCCn1c(Sc2nc3cccc(Cl)c3s2)nc2c(N)ncnc12
Show InChI InChI=1S/C17H17ClN6S2/c1-2-3-4-8-24-15-12(14(19)20-9-21-15)23-16(24)26-17-22-11-7-5-6-10(18)13(11)25-17/h5-7,9H,2-4,8H2,1H3,(H2,19,20,21)
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n/an/an/an/a 700n/an/a7.237



Conforma Therapeutics Corporation



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 49: 5352-62 (2006)


Article DOI: 10.1021/jm051146h
BindingDB Entry DOI: 10.7270/Q26M354P
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20768
PNG
(2-{6-amino-8-[(7-chloro-1,3-benzothiazol-2-yl)sulf...)
Show SMILES CC(=O)OCCn1c(Sc2nc3cccc(Cl)c3s2)nc2c(N)ncnc12
Show InChI InChI=1S/C16H13ClN6O2S2/c1-8(24)25-6-5-23-14-11(13(18)19-7-20-14)22-15(23)27-16-21-10-4-2-3-9(17)12(10)26-16/h2-4,7H,5-6H2,1H3,(H2,18,19,20)
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n/an/an/an/a 150n/an/a7.237



Conforma Therapeutics Corporation



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 49: 5352-62 (2006)


Article DOI: 10.1021/jm051146h
BindingDB Entry DOI: 10.7270/Q26M354P
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20769
PNG
(3-{6-amino-8-[(7-chloro-1,3-benzothiazol-2-yl)sulf...)
Show SMILES CC(=O)OCCCn1c(Sc2nc3cccc(Cl)c3s2)nc2c(N)ncnc12
Show InChI InChI=1S/C17H15ClN6O2S2/c1-9(25)26-7-3-6-24-15-12(14(19)20-8-21-15)23-16(24)28-17-22-11-5-2-4-10(18)13(11)27-17/h2,4-5,8H,3,6-7H2,1H3,(H2,19,20,21)
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n/an/an/an/a 90n/an/a7.237



Conforma Therapeutics Corporation



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 49: 5352-62 (2006)


Article DOI: 10.1021/jm051146h
BindingDB Entry DOI: 10.7270/Q26M354P
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20770
PNG
(4-{6-amino-8-[(7-chloro-1,3-benzothiazol-2-yl)sulf...)
Show SMILES CC(=O)OCCCCn1c(Sc2nc3cccc(Cl)c3s2)nc2c(N)ncnc12
Show InChI InChI=1S/C18H17ClN6O2S2/c1-10(26)27-8-3-2-7-25-16-13(15(20)21-9-22-16)24-17(25)29-18-23-12-6-4-5-11(19)14(12)28-18/h4-6,9H,2-3,7-8H2,1H3,(H2,20,21,22)
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n/an/an/an/a 130n/an/a7.237



Conforma Therapeutics Corporation



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 49: 5352-62 (2006)


Article DOI: 10.1021/jm051146h
BindingDB Entry DOI: 10.7270/Q26M354P
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20771
PNG
(Benzothiazole analogue, 24 | CHEMBL377371 | diethy...)
Show SMILES CCOP(=O)(CCn1c(Sc2nc3cccc(Cl)c3s2)nc2c(N)ncnc12)OCC
Show InChI InChI=1S/C18H20ClN6O3PS2/c1-3-27-29(26,28-4-2)9-8-25-16-13(15(20)21-10-22-16)24-17(25)31-18-23-12-7-5-6-11(19)14(12)30-18/h5-7,10H,3-4,8-9H2,1-2H3,(H2,20,21,22)
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n/an/an/an/a 30n/an/a7.237



Conforma Therapeutics Corporation



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 49: 5352-62 (2006)


Article DOI: 10.1021/jm051146h
BindingDB Entry DOI: 10.7270/Q26M354P
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20772
PNG
(5-{6-amino-8-[(7-chloro-1,3-benzothiazol-2-yl)sulf...)
Show SMILES Nc1ncnc2n(CCCCC#N)c(Sc3nc4cccc(Cl)c4s3)nc12
Show InChI InChI=1S/C17H14ClN7S2/c18-10-5-4-6-11-13(10)26-17(23-11)27-16-24-12-14(20)21-9-22-15(12)25(16)8-3-1-2-7-19/h4-6,9H,1-3,8H2,(H2,20,21,22)
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n/an/an/an/a 110n/an/a7.237



Conforma Therapeutics Corporation



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 49: 5352-62 (2006)


Article DOI: 10.1021/jm051146h
BindingDB Entry DOI: 10.7270/Q26M354P
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20773
PNG
(2-{6-amino-8-[(7-chloro-1,3-benzothiazol-2-yl)sulf...)
Show SMILES Nc1ncnc2n(CCO)c(Sc3nc4cccc(Cl)c4s3)nc12
Show InChI InChI=1S/C14H11ClN6OS2/c15-7-2-1-3-8-10(7)23-14(19-8)24-13-20-9-11(16)17-6-18-12(9)21(13)4-5-22/h1-3,6,22H,4-5H2,(H2,16,17,18)
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n/an/an/an/a 300n/an/a7.237



Conforma Therapeutics Corporation



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 49: 5352-62 (2006)


Article DOI: 10.1021/jm051146h
BindingDB Entry DOI: 10.7270/Q26M354P
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20774
PNG
(3-{6-amino-8-[(7-chloro-1,3-benzothiazol-2-yl)sulf...)
Show SMILES Nc1ncnc2n(CCCO)c(Sc3nc4cccc(Cl)c4s3)nc12
Show InChI InChI=1S/C15H13ClN6OS2/c16-8-3-1-4-9-11(8)24-15(20-9)25-14-21-10-12(17)18-7-19-13(10)22(14)5-2-6-23/h1,3-4,7,23H,2,5-6H2,(H2,17,18,19)
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n/an/an/an/a 150n/an/a7.237



Conforma Therapeutics Corporation



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 49: 5352-62 (2006)


Article DOI: 10.1021/jm051146h
BindingDB Entry DOI: 10.7270/Q26M354P
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20775
PNG
(4-{6-amino-8-[(7-chloro-1,3-benzothiazol-2-yl)sulf...)
Show SMILES Nc1ncnc2n(CCCCO)c(Sc3nc4cccc(Cl)c4s3)nc12
Show InChI InChI=1S/C16H15ClN6OS2/c17-9-4-3-5-10-12(9)25-16(21-10)26-15-22-11-13(18)19-8-20-14(11)23(15)6-1-2-7-24/h3-5,8,24H,1-2,6-7H2,(H2,18,19,20)
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n/an/an/an/a 150n/an/a7.237



Conforma Therapeutics Corporation



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 49: 5352-62 (2006)


Article DOI: 10.1021/jm051146h
BindingDB Entry DOI: 10.7270/Q26M354P
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20776
PNG
(8-[(7-chloro-1,3-benzothiazol-2-yl)sulfanyl]-9-[2-...)
Show SMILES Nc1ncnc2n(CCN3CCOCC3)c(Sc3nc4cccc(Cl)c4s3)nc12
Show InChI InChI=1S/C18H18ClN7OS2/c19-11-2-1-3-12-14(11)28-18(23-12)29-17-24-13-15(20)21-10-22-16(13)26(17)5-4-25-6-8-27-9-7-25/h1-3,10H,4-9H2,(H2,20,21,22)
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n/an/an/an/a 250n/an/a7.237



Conforma Therapeutics Corporation



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 49: 5352-62 (2006)


Article DOI: 10.1021/jm051146h
BindingDB Entry DOI: 10.7270/Q26M354P
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20787
PNG
(2-amino-6-halopurine analogue, 26 | 6-chloro-9-[(2...)
Show SMILES COc1ccc(OC)c(Cn2cnc3c(Cl)nc(N)nc23)c1
Show InChI InChI=1S/C14H14ClN5O2/c1-21-9-3-4-10(22-2)8(5-9)6-20-7-17-11-12(15)18-14(16)19-13(11)20/h3-5,7H,6H2,1-2H3,(H2,16,18,19)
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n/an/an/an/a 3.00E+3n/an/a7.237



Biogen Idec



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 50: 2767-78 (2007)


Article DOI: 10.1021/jm050752+
BindingDB Entry DOI: 10.7270/Q22Z13ST
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20788
PNG
(2-amino-6-halopurine analogue, 17 | 6-chloro-9-[(3...)
Show SMILES COc1cc(Cn2cnc3c(Cl)nc(N)nc23)cc(OC)c1OC
Show InChI InChI=1S/C15H16ClN5O3/c1-22-9-4-8(5-10(23-2)12(9)24-3)6-21-7-18-11-13(16)19-15(17)20-14(11)21/h4-5,7H,6H2,1-3H3,(H2,17,19,20)
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n/an/an/an/a 2.00E+3n/an/a7.237



Biogen Idec



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 50: 2767-78 (2007)


Article DOI: 10.1021/jm050752+
BindingDB Entry DOI: 10.7270/Q22Z13ST
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20789
PNG
(2-amino-6-halopurine analogue, 18a | 6-chloro-9-[(...)
Show SMILES COc1cc(Cn2cnc3c(Cl)nc(N)nc23)c(Cl)c(OC)c1OC
Show InChI InChI=1S/C15H15Cl2N5O3/c1-23-8-4-7(9(16)12(25-3)11(8)24-2)5-22-6-19-10-13(17)20-15(18)21-14(10)22/h4,6H,5H2,1-3H3,(H2,18,20,21)
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n/an/an/an/a 50n/an/a7.237



Biogen Idec



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 50: 2767-78 (2007)


Article DOI: 10.1021/jm050752+
BindingDB Entry DOI: 10.7270/Q22Z13ST
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20790
PNG
(2-amino-6-halopurine analogue, 18b | 9-[(2-bromo-3...)
Show SMILES COc1cc(Cn2cnc3c(Cl)nc(N)nc23)c(Br)c(OC)c1OC
Show InChI InChI=1S/C15H15BrClN5O3/c1-23-8-4-7(9(16)12(25-3)11(8)24-2)5-22-6-19-10-13(17)20-15(18)21-14(10)22/h4,6H,5H2,1-3H3,(H2,18,20,21)
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n/an/an/an/a 70n/an/a7.237



Biogen Idec



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 50: 2767-78 (2007)


Article DOI: 10.1021/jm050752+
BindingDB Entry DOI: 10.7270/Q22Z13ST
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20791
PNG
(2-amino-6-halopurine analogue, 18c | 6-chloro-9-[(...)
Show SMILES COc1cc(Cn2cnc3c(Cl)nc(N)nc23)c(I)c(OC)c1OC
Show InChI InChI=1S/C15H15ClIN5O3/c1-23-8-4-7(9(17)12(25-3)11(8)24-2)5-22-6-19-10-13(16)20-15(18)21-14(10)22/h4,6H,5H2,1-3H3,(H2,18,20,21)
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n/an/an/an/a 340n/an/a7.237



Biogen Idec



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 50: 2767-78 (2007)


Article DOI: 10.1021/jm050752+
BindingDB Entry DOI: 10.7270/Q22Z13ST
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20792
PNG
(2-amino-6-halopurine analogue, 27 | 6-bromo-9-[(2-...)
Show SMILES COc1cc(Cn2cnc3c(Br)nc(N)nc23)c(Br)c(OC)c1OC
Show InChI InChI=1S/C15H15Br2N5O3/c1-23-8-4-7(9(16)12(25-3)11(8)24-2)5-22-6-19-10-13(17)20-15(18)21-14(10)22/h4,6H,5H2,1-3H3,(H2,18,20,21)
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n/an/an/an/a 55n/an/a7.237



Biogen Idec



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 50: 2767-78 (2007)


Article DOI: 10.1021/jm050752+
BindingDB Entry DOI: 10.7270/Q22Z13ST
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20793
PNG
(2-amino-6-halopurine analogue, 19a | 9-[(2-bromo-3...)
Show SMILES COc1cc(Cn2cnc3c(N)nc(N)nc23)c(Br)c(OC)c1OC
Show InChI InChI=1S/C15H17BrN6O3/c1-23-8-4-7(9(16)12(25-3)11(8)24-2)5-22-6-19-10-13(17)20-15(18)21-14(10)22/h4,6H,5H2,1-3H3,(H4,17,18,20,21)
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n/an/an/an/a 1.70E+4n/an/a7.237



Biogen Idec



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 50: 2767-78 (2007)


Article DOI: 10.1021/jm050752+
BindingDB Entry DOI: 10.7270/Q22Z13ST
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20794
PNG
(2-amino-6-halopurine analogue, 19b | 9-[(2-bromo-3...)
Show SMILES COc1cc(Cn2cnc3c(OC)nc(N)nc23)c(Br)c(OC)c1OC
Show InChI InChI=1S/C16H18BrN5O4/c1-23-9-5-8(10(17)13(25-3)12(9)24-2)6-22-7-19-11-14(22)20-16(18)21-15(11)26-4/h5,7H,6H2,1-4H3,(H2,18,20,21)
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n/an/an/an/a 4.50E+4n/an/a7.237



Biogen Idec



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 50: 2767-78 (2007)


Article DOI: 10.1021/jm050752+
BindingDB Entry DOI: 10.7270/Q22Z13ST
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20795
PNG
(2-amino-6-halopurine analogue, 19c | 2-amino-9-[(2...)
Show SMILES COc1cc(Cn2cnc3c2nc(N)[nH]c3=O)c(Cl)c(OC)c1OC
Show InChI InChI=1S/C15H16ClN5O4/c1-23-8-4-7(9(16)12(25-3)11(8)24-2)5-21-6-18-10-13(21)19-15(17)20-14(10)22/h4,6H,5H2,1-3H3,(H3,17,19,20,22)
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n/an/an/an/a 700n/an/a7.237



Biogen Idec



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 50: 2767-78 (2007)


Article DOI: 10.1021/jm050752+
BindingDB Entry DOI: 10.7270/Q22Z13ST
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20796
PNG
(2-amino-6-halopurine analogue, 19d | 2-amino-9-[(2...)
Show SMILES COc1cc(Cn2cnc3c2nc(N)[nH]c3=S)c(Br)c(OC)c1OC
Show InChI InChI=1S/C15H16BrN5O3S/c1-22-8-4-7(9(16)12(24-3)11(8)23-2)5-21-6-18-10-13(21)19-15(17)20-14(10)25/h4,6H,5H2,1-3H3,(H3,17,19,20,25)
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n/an/an/an/a 1.00E+5n/an/a7.237



Biogen Idec



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 50: 2767-78 (2007)


Article DOI: 10.1021/jm050752+
BindingDB Entry DOI: 10.7270/Q22Z13ST
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20797
PNG
(2-amino-6-halopurine analogue, 19e | 9-[(2-bromo-3...)
Show SMILES COc1cc(Cn2cnc3cnc(N)nc23)c(Br)c(OC)c1OC
Show InChI InChI=1S/C15H16BrN5O3/c1-22-10-4-8(11(16)13(24-3)12(10)23-2)6-21-7-19-9-5-18-15(17)20-14(9)21/h4-5,7H,6H2,1-3H3,(H2,17,18,20)
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n/an/an/an/a 5.00E+4n/an/a7.237



Biogen Idec



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 50: 2767-78 (2007)


Article DOI: 10.1021/jm050752+
BindingDB Entry DOI: 10.7270/Q22Z13ST
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20798
PNG
(2-amino-6-halopurine analogue, 19f | 9-[(2-chloro-...)
Show SMILES COc1cc(Cn2cnc3c(C)nc(N)nc23)c(Cl)c(OC)c1OC
Show InChI InChI=1S/C16H18ClN5O3/c1-8-12-15(21-16(18)20-8)22(7-19-12)6-9-5-10(23-2)13(24-3)14(25-4)11(9)17/h5,7H,6H2,1-4H3,(H2,18,20,21)
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n/an/an/an/a 1.80E+3n/an/a7.237



Biogen Idec



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 50: 2767-78 (2007)


Article DOI: 10.1021/jm050752+
BindingDB Entry DOI: 10.7270/Q22Z13ST
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM15359
PNG
((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-...)
Show SMILES CO[C@H]1C[C@H](C)Cc2c(O)c(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)cc(O)c2N=CC=C
Show InChI InChI=1S/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-12,15-17,19,24-25,27,29,35-37H,1,13-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9?,18-10?,20-15+,33-12?/t17-,19+,24+,25+,27-,29+/m1/s1
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n/an/an/an/a 7n/an/a7.237



Biogen Idec



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 50: 2767-78 (2007)


Article DOI: 10.1021/jm050752+
BindingDB Entry DOI: 10.7270/Q22Z13ST
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM15381
PNG
(8-(2-chloro-3,4,5-trimethoxybenzyl)-2-fluoro-9-pen...)
Show SMILES COc1cc(Cc2nc3c(N)nc(F)nc3n2CCCC#C)c(Cl)c(OC)c1OC
Show InChI InChI=1S/C20H21ClFN5O3/c1-5-6-7-8-27-13(24-15-18(23)25-20(22)26-19(15)27)10-11-9-12(28-2)16(29-3)17(30-4)14(11)21/h1,9H,6-8,10H2,2-4H3,(H2,23,25,26)
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n/an/an/an/a 1.70E+3n/an/a7.237



Biogen Idec



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 50: 2767-78 (2007)


Article DOI: 10.1021/jm050752+
BindingDB Entry DOI: 10.7270/Q22Z13ST
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20753
PNG
(9-{2-[(2,2-dimethylpropyl)amino]ethyl}-8-[(2-iodo-...)
Show SMILES COc1ccc(I)c(Sc2nc3c(N)ncnc3n2CCNCC(C)(C)C)c1
Show InChI InChI=1S/C19H25IN6OS/c1-19(2,3)10-22-7-8-26-17-15(16(21)23-11-24-17)25-18(26)28-14-9-12(27-4)5-6-13(14)20/h5-6,9,11,22H,7-8,10H2,1-4H3,(H2,21,23,24)
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n/an/an/an/a 90n/an/a7.237



Biogen Idec



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 50: 2767-78 (2007)


Article DOI: 10.1021/jm050752+
BindingDB Entry DOI: 10.7270/Q22Z13ST
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20799
PNG
(2-amino-6-halopurine analogue, 16 | 6-chloro-9-[(5...)
Show SMILES COc1c(C)ncc(Cn2cnc3c(Cl)nc(N)nc23)c1C
Show InChI InChI=1S/C14H15ClN6O/c1-7-9(4-17-8(2)11(7)22-3)5-21-6-18-10-12(15)19-14(16)20-13(10)21/h4,6H,5H2,1-3H3,(H2,16,19,20)
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n/an/an/an/a 20n/an/a7.237



Biogen Idec



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 50: 2767-78 (2007)


Article DOI: 10.1021/jm050752+
BindingDB Entry DOI: 10.7270/Q22Z13ST
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20800
PNG
(2-amino-6-halopurine analogue, 20 | 6-chloro-9-[(4...)
Show SMILES COc1c(C)cnc(Cn2cnc3c(Cl)nc(N)nc23)c1C
Show InChI InChI=1S/C14H15ClN6O/c1-7-4-17-9(8(2)11(7)22-3)5-21-6-18-10-12(15)19-14(16)20-13(10)21/h4,6H,5H2,1-3H3,(H2,16,19,20)
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n/an/an/an/a 30n/an/a7.237



Biogen Idec



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 50: 2767-78 (2007)


Article DOI: 10.1021/jm050752+
BindingDB Entry DOI: 10.7270/Q22Z13ST
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20801
PNG
(2-[(2-amino-6-chloro-9H-purin-9-yl)methyl]-3,5-dim...)
Show SMILES Cc1cnc(Cn2cnc3c(Cl)nc(N)nc23)c(C)c1O
Show InChI InChI=1S/C13H13ClN6O/c1-6-3-16-8(7(2)10(6)21)4-20-5-17-9-11(14)18-13(15)19-12(9)20/h3,5H,4H2,1-2H3,(H,16,21)(H2,15,18,19)
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n/an/an/an/a 1.00E+5n/an/a7.237



Biogen Idec



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 50: 2767-78 (2007)


Article DOI: 10.1021/jm050752+
BindingDB Entry DOI: 10.7270/Q22Z13ST
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20802
PNG
(2-amino-6-halopurine analogue, 22 | 6-chloro-9-[(4...)
Show SMILES CCOc1c(C)cnc(Cn2cnc3c(Cl)nc(N)nc23)c1C
Show InChI InChI=1S/C15H17ClN6O/c1-4-23-12-8(2)5-18-10(9(12)3)6-22-7-19-11-13(16)20-15(17)21-14(11)22/h5,7H,4,6H2,1-3H3,(H2,17,20,21)
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n/an/an/an/a 1.50E+3n/an/a7.237



Biogen Idec



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 50: 2767-78 (2007)


Article DOI: 10.1021/jm050752+
BindingDB Entry DOI: 10.7270/Q22Z13ST
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20803
PNG
(2-amino-6-halopurine analogue, 23 | 6-chloro-9-{[3...)
Show SMILES CC(C)Oc1c(C)cnc(Cn2cnc3c(Cl)nc(N)nc23)c1C
Show InChI InChI=1S/C16H19ClN6O/c1-8(2)24-13-9(3)5-19-11(10(13)4)6-23-7-20-12-14(17)21-16(18)22-15(12)23/h5,7-8H,6H2,1-4H3,(H2,18,21,22)
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n/an/an/an/a 1.50E+3n/an/a7.237



Biogen Idec



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 50: 2767-78 (2007)


Article DOI: 10.1021/jm050752+
BindingDB Entry DOI: 10.7270/Q22Z13ST
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20804
PNG
(2-[(2-amino-6-chloro-9H-purin-9-yl)methyl]-4-metho...)
Show SMILES COc1c(C)c[n+]([O-])c(Cn2cnc3c(Cl)nc(N)nc23)c1C
Show InChI InChI=1S/C14H15ClN6O2/c1-7-4-21(22)9(8(2)11(7)23-3)5-20-6-17-10-12(15)18-14(16)19-13(10)20/h4,6H,5H2,1-3H3,(H2,16,18,19)
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n/an/an/an/a 80n/an/a7.237



Biogen Idec



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 50: 2767-78 (2007)


Article DOI: 10.1021/jm050752+
BindingDB Entry DOI: 10.7270/Q22Z13ST
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20805
PNG
(2-amino-6-halopurine analogue, 25 | 6-chloro-9-[(6...)
Show SMILES COc1c(C)c(Cl)nc(Cn2cnc3c(Cl)nc(N)nc23)c1C
Show InChI InChI=1S/C14H14Cl2N6O/c1-6-8(19-11(15)7(2)10(6)23-3)4-22-5-18-9-12(16)20-14(17)21-13(9)22/h5H,4H2,1-3H3,(H2,17,20,21)
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n/an/an/an/a 90n/an/a7.237



Biogen Idec



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 50: 2767-78 (2007)


Article DOI: 10.1021/jm050752+
BindingDB Entry DOI: 10.7270/Q22Z13ST
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM15374
PNG
(9-butyl-8-(3,4,5-trimethoxybenzyl)-9H-purin-6-amin...)
Show SMILES CCCCn1c(Cc2cc(OC)c(OC)c(OC)c2)nc2c(N)ncnc12
Show InChI InChI=1S/C19H25N5O3/c1-5-6-7-24-15(23-16-18(20)21-11-22-19(16)24)10-12-8-13(25-2)17(27-4)14(9-12)26-3/h8-9,11H,5-7,10H2,1-4H3,(H2,20,21,22)
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n/an/an/an/a 4.00E+4n/an/a7.237



Conforma Therapeutics Corporation



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 49: 817-28 (2006)


Article DOI: 10.1021/jm0503087
BindingDB Entry DOI: 10.7270/Q2BC3WT5
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM15378
PNG
(9-butyl-8-(2,5-dimethoxybenzyl)-9H-purin-6-amine |...)
Show SMILES CCCCn1c(Cc2cc(OC)ccc2OC)nc2c(N)ncnc12
Show InChI InChI=1S/C18H23N5O2/c1-4-5-8-23-15(22-16-17(19)20-11-21-18(16)23)10-12-9-13(24-2)6-7-14(12)25-3/h6-7,9,11H,4-5,8,10H2,1-3H3,(H2,19,20,21)
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n/an/an/an/a 1.20E+4n/an/a7.237



Conforma Therapeutics Corporation



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 49: 817-28 (2006)


Article DOI: 10.1021/jm0503087
BindingDB Entry DOI: 10.7270/Q2BC3WT5
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20741
PNG
(8-benzyladenine analogue, 12b | 9-butyl-8-[(2-chlo...)
Show SMILES CCCCn1c(Cc2cc(OC)ccc2Cl)nc2c(N)ncnc12
Show InChI InChI=1S/C17H20ClN5O/c1-3-4-7-23-14(22-15-16(19)20-10-21-17(15)23)9-11-8-12(24-2)5-6-13(11)18/h5-6,8,10H,3-4,7,9H2,1-2H3,(H2,19,20,21)
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n/an/an/an/a 2.00E+4n/an/a7.237



Conforma Therapeutics Corporation



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 49: 817-28 (2006)


Article DOI: 10.1021/jm0503087
BindingDB Entry DOI: 10.7270/Q2BC3WT5
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20742
PNG
(8-[(2-bromo-5-methoxyphenyl)methyl]-9-butyl-9H-pur...)
Show SMILES CCCCn1c(Cc2cc(OC)ccc2Br)nc2c(N)ncnc12
Show InChI InChI=1S/C17H20BrN5O/c1-3-4-7-23-14(22-15-16(19)20-10-21-17(15)23)9-11-8-12(24-2)5-6-13(11)18/h5-6,8,10H,3-4,7,9H2,1-2H3,(H2,19,20,21)
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n/an/an/an/a 8.00E+3n/an/a7.237



Conforma Therapeutics Corporation



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 49: 817-28 (2006)


Article DOI: 10.1021/jm0503087
BindingDB Entry DOI: 10.7270/Q2BC3WT5
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20743
PNG
(8-benzyladenine analogue, 12d | 9-butyl-8-[(2-iodo...)
Show SMILES CCCCn1c(Cc2cc(OC)ccc2I)nc2c(N)ncnc12
Show InChI InChI=1S/C17H20IN5O/c1-3-4-7-23-14(22-15-16(19)20-10-21-17(15)23)9-11-8-12(24-2)5-6-13(11)18/h5-6,8,10H,3-4,7,9H2,1-2H3,(H2,19,20,21)
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n/an/an/an/a 5.00E+3n/an/a7.237



Conforma Therapeutics Corporation



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 49: 817-28 (2006)


Article DOI: 10.1021/jm0503087
BindingDB Entry DOI: 10.7270/Q2BC3WT5
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20744
PNG
(8-sulfanyladenine analogue, 18 | 9-butyl-8-[(2,5-d...)
Show SMILES CCCCn1c(Sc2cc(OC)ccc2OC)nc2c(N)ncnc12
Show InChI InChI=1S/C17H21N5O2S/c1-4-5-8-22-16-14(15(18)19-10-20-16)21-17(22)25-13-9-11(23-2)6-7-12(13)24-3/h6-7,9-10H,4-5,8H2,1-3H3,(H2,18,19,20)
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n/an/an/an/a 3.50E+3n/an/a7.237



Conforma Therapeutics Corporation



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 49: 817-28 (2006)


Article DOI: 10.1021/jm0503087
BindingDB Entry DOI: 10.7270/Q2BC3WT5
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20745
PNG
(8-Sulfanyladenine | 8-[(2-iodo-5-methoxyphenyl)sul...)
Show SMILES COc1ccc(I)c(Sc2nc3c(N)ncnc3n2CCCC#C)c1
Show InChI InChI=1S/C17H16IN5OS/c1-3-4-5-8-23-16-14(15(19)20-10-21-16)22-17(23)25-13-9-11(24-2)6-7-12(13)18/h1,6-7,9-10H,4-5,8H2,2H3,(H2,19,20,21)
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n/an/an/an/a 280n/an/a7.237



Conforma Therapeutics Corporation



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 49: 817-28 (2006)


Article DOI: 10.1021/jm0503087
BindingDB Entry DOI: 10.7270/Q2BC3WT5
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20746
PNG
(8-[(2-iodo-5-methoxyphenyl)sulfanyl]-9-(4-methylpe...)
Show SMILES COc1ccc(I)c(Sc2nc3c(N)ncnc3n2CCC=C(C)C)c1
Show InChI InChI=1S/C18H20IN5OS/c1-11(2)5-4-8-24-17-15(16(20)21-10-22-17)23-18(24)26-14-9-12(25-3)6-7-13(14)19/h5-7,9-10H,4,8H2,1-3H3,(H2,20,21,22)
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n/an/an/an/a 370n/an/a7.237



Conforma Therapeutics Corporation



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 49: 817-28 (2006)


Article DOI: 10.1021/jm0503087
BindingDB Entry DOI: 10.7270/Q2BC3WT5
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20747
PNG
(2-fluoro-8-[(2-iodo-5-methoxyphenyl)sulfanyl]-9-(p...)
Show SMILES COc1ccc(I)c(Sc2nc3c(N)nc(F)nc3n2CCCC#C)c1
Show InChI InChI=1S/C17H15FIN5OS/c1-3-4-5-8-24-15-13(14(20)22-16(18)23-15)21-17(24)26-12-9-10(25-2)6-7-11(12)19/h1,6-7,9H,4-5,8H2,2H3,(H2,20,22,23)
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n/an/an/an/a 360n/an/a7.237



Conforma Therapeutics Corporation



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 49: 817-28 (2006)


Article DOI: 10.1021/jm0503087
BindingDB Entry DOI: 10.7270/Q2BC3WT5
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM15381
PNG
(8-(2-chloro-3,4,5-trimethoxybenzyl)-2-fluoro-9-pen...)
Show SMILES COc1cc(Cc2nc3c(N)nc(F)nc3n2CCCC#C)c(Cl)c(OC)c1OC
Show InChI InChI=1S/C20H21ClFN5O3/c1-5-6-7-8-27-13(24-15-18(23)25-20(22)26-19(15)27)10-11-9-12(28-2)16(29-3)17(30-4)14(11)21/h1,9H,6-8,10H2,2-4H3,(H2,23,25,26)
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n/an/an/an/a 1.70E+3n/an/a7.237



Conforma Therapeutics Corporation



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 49: 817-28 (2006)


Article DOI: 10.1021/jm0503087
BindingDB Entry DOI: 10.7270/Q2BC3WT5
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20748
PNG
(8-[(2-iodo-5-methoxyphenyl)sulfanyl]-9-[3-(pentan-...)
Show SMILES CCC(CC)NCCCn1c(Sc2cc(OC)ccc2I)nc2c(N)ncnc12
Show InChI InChI=1S/C20H27IN6OS/c1-4-13(5-2)23-9-6-10-27-19-17(18(22)24-12-25-19)26-20(27)29-16-11-14(28-3)7-8-15(16)21/h7-8,11-13,23H,4-6,9-10H2,1-3H3,(H2,22,24,25)
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n/an/an/an/a 210n/an/a7.237



Conforma Therapeutics Corporation



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 49: 817-28 (2006)


Article DOI: 10.1021/jm0503087
BindingDB Entry DOI: 10.7270/Q2BC3WT5
More data for this
Ligand-Target Pair
HSP90 and hnRNPA2/B1


(Homo sapiens (human))
BDBM20749
PNG
(9-[3-(butan-2-ylamino)propyl]-8-[(2-iodo-5-methoxy...)
Show SMILES CCC(C)NCCCn1c(Sc2cc(OC)ccc2I)nc2c(N)ncnc12
Show InChI InChI=1S/C19H25IN6OS/c1-4-12(2)22-8-5-9-26-18-16(17(21)23-11-24-18)25-19(26)28-15-10-13(27-3)6-7-14(15)20/h6-7,10-12,22H,4-5,8-9H2,1-3H3,(H2,21,23,24)
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n/an/an/an/a 210n/an/a7.237



Conforma Therapeutics Corporation



Assay Description
EC50 was defined as the concentration of the compound at which there was 50% degradation of the Her-2/neu protein in MCF7 breast carcinoma cells. Sam...


J Med Chem 49: 817-28 (2006)


Article DOI: 10.1021/jm0503087
BindingDB Entry DOI: 10.7270/Q2BC3WT5
More data for this
Ligand-Target Pair
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