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Found 4597 hits Enz. Inhib. hit(s) with Target = 'Hepatocyte growth factor receptor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM109202
PNG
(US8604028, 61)
Show SMILES CC1=NC(=C([N+]#[C-])C(C1C#N)c1cc2c(N)nccc2o1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H14ClN5O/c1-11-15(10-23)18(17-9-14-16(28-17)7-8-26-21(14)24)20(25-2)19(27-11)12-3-5-13(22)6-4-12/h3-9,15,18H,1H3,(H2,24,26)
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n/an/a 43n/an/an/an/a7.032



Bayer Intellectual Property GmbH

US Patent


Assay Description
Tyrosine kinase activity assay (NADH Read-Out)using human c-Met protein (Invitrogen, Carlsbad, Calif., USA). The amount of phosphorylated substrate ...


US Patent US8604028 (2013)


BindingDB Entry DOI: 10.7270/Q23T9FVT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM103458
PNG
(US8551989, 3)
Show SMILES CC1=NC(C)=C(C#N)C(C1C#N)c1ccc2[nH]nc(c2c1)S(C)(=O)=O
Show InChI InChI=1S/C17H15N5O2S/c1-9-13(7-18)16(14(8-19)10(2)20-9)11-4-5-15-12(6-11)17(22-21-15)25(3,23)24/h4-6,13,16H,1-3H3,(H,21,22)
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n/an/a 77n/an/an/an/a7.032



Bayer Intellectual Property GmbH

US Patent


Assay Description
Tyrosine kinase activity assay (NADH Read-Out) using c-Met receptor.


US Patent US8551989 (2013)


BindingDB Entry DOI: 10.7270/Q24F1PCX
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM109200
PNG
(US8604028, 56)
Show SMILES CC1=NC(C)=C([N+]#[C-])C(C1C#N)c1cc2c(N)nccc2o1
Show InChI InChI=1S/C16H13N5O/c1-8-11(7-17)14(15(19-3)9(2)21-8)13-6-10-12(22-13)4-5-20-16(10)18/h4-6,11,14H,1-2H3,(H2,18,20)
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n/an/a 23n/an/an/an/a7.032



Bayer Intellectual Property GmbH

US Patent


Assay Description
Tyrosine kinase activity assay (NADH Read-Out)using human c-Met protein (Invitrogen, Carlsbad, Calif., USA). The amount of phosphorylated substrate ...


US Patent US8604028 (2013)


BindingDB Entry DOI: 10.7270/Q23T9FVT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM103464
PNG
(US8551989, 25)
Show SMILES COCCN(C)c1n[nH]c2ccc(cc12)C1C(C#N)C(C)=NC(C)=C1C#N
Show InChI InChI=1S/C20H22N6O/c1-12-16(10-21)19(17(11-22)13(2)23-12)14-5-6-18-15(9-14)20(25-24-18)26(3)7-8-27-4/h5-6,9,16,19H,7-8H2,1-4H3,(H,24,25)
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n/an/a 8n/an/an/an/a7.032



Bayer Intellectual Property GmbH

US Patent


Assay Description
Tyrosine kinase activity assay (NADH Read-Out) using c-Met receptor.


US Patent US8551989 (2013)


BindingDB Entry DOI: 10.7270/Q24F1PCX
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM103463
PNG
(US8551989, 24)
Show SMILES CC(C)OCCOc1n[nH]c2ccc(cc12)C1C(C#N)C(=NC(C(F)F)=C1C#N)C(F)F
Show InChI InChI=1S/C21H19F4N5O2/c1-10(2)31-5-6-32-21-12-7-11(3-4-15(12)29-30-21)16-13(8-26)17(19(22)23)28-18(20(24)25)14(16)9-27/h3-4,7,10,13,16,19-20H,5-6H2,1-2H3,(H,29,30)
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n/an/a 38n/an/an/an/a7.032



Bayer Intellectual Property GmbH

US Patent


Assay Description
Tyrosine kinase activity assay (NADH Read-Out) using c-Met receptor.


US Patent US8551989 (2013)


BindingDB Entry DOI: 10.7270/Q24F1PCX
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM103460
PNG
(US8551989, 13)
Show SMILES COc1n[nH]c2ccc(cc12)C1C(C#N)C(C)=NC(C)=C1C#N
Show InChI InChI=1S/C17H15N5O/c1-9-13(7-18)16(14(8-19)10(2)20-9)11-4-5-15-12(6-11)17(23-3)22-21-15/h4-6,13,16H,1-3H3,(H,21,22)
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n/an/a 8n/an/an/an/a7.032



Bayer Intellectual Property GmbH

US Patent


Assay Description
Tyrosine kinase activity assay (NADH Read-Out) using c-Met receptor.


US Patent US8551989 (2013)


BindingDB Entry DOI: 10.7270/Q24F1PCX
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM103459
PNG
(US8551989, 12)
Show SMILES CCCS(=O)(=O)Nc1n[nH]c2ccc(cc12)C1C(C#N)C(C)=NC(C)=C1C#N
Show InChI InChI=1S/C19H20N6O2S/c1-4-7-28(26,27)25-19-14-8-13(5-6-17(14)23-24-19)18-15(9-20)11(2)22-12(3)16(18)10-21/h5-6,8,15,18H,4,7H2,1-3H3,(H2,23,24,25)
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n/an/a 475n/an/an/an/a7.032



Bayer Intellectual Property GmbH

US Patent


Assay Description
Tyrosine kinase activity assay (NADH Read-Out) using c-Met receptor.


US Patent US8551989 (2013)


BindingDB Entry DOI: 10.7270/Q24F1PCX
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM109203
PNG
(US8604028, 65)
Show SMILES CC1=NC2=C(C(C1[N+]#[C-])c1cc3c(NC(=O)c4ccccc4)nccc3o1)C(=O)OC2
Show InChI InChI=1S/C23H16N4O4/c1-12-20(24-2)19(18-15(26-12)11-30-23(18)29)17-10-14-16(31-17)8-9-25-21(14)27-22(28)13-6-4-3-5-7-13/h3-10,19-20H,11H2,1H3,(H,25,27,28)
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n/an/a 142n/an/an/an/a7.032



Bayer Intellectual Property GmbH

US Patent


Assay Description
Tyrosine kinase activity assay (NADH Read-Out)using human c-Met protein (Invitrogen, Carlsbad, Calif., USA). The amount of phosphorylated substrate ...


US Patent US8604028 (2013)


BindingDB Entry DOI: 10.7270/Q23T9FVT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM109204
PNG
(US8604028, 70)
Show SMILES CC1=C(C#N)[C@@H](c2cc3c(N)nccc3o2)C([N+]#[C-])=C2COCCN12
Show InChI InChI=1S/C18H15N5O2/c1-10-12(8-19)16(17(21-2)13-9-24-6-5-23(10)13)15-7-11-14(25-15)3-4-22-18(11)20/h3-4,7,16H,5-6,9H2,1H3,(H2,20,22)/t16-/m0/s1
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n/an/a 610n/an/an/an/a7.032



Bayer Intellectual Property GmbH

US Patent


Assay Description
Tyrosine kinase activity assay (NADH Read-Out)using human c-Met protein (Invitrogen, Carlsbad, Calif., USA). The amount of phosphorylated substrate ...


US Patent US8604028 (2013)


BindingDB Entry DOI: 10.7270/Q23T9FVT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM109205
PNG
(US8604028, 72)
Show SMILES Nc1nccc2oc(cc12)[C@@H]1C2C(=O)OCC2=NC(=C1[N+]#[C-])c1ccc(Cl)cc1
Show InChI InChI=1S/C21H13ClN4O3/c1-24-19-17(15-8-12-14(29-15)6-7-25-20(12)23)16-13(9-28-21(16)27)26-18(19)10-2-4-11(22)5-3-10/h2-8,16-17H,9H2,(H2,23,25)/t16?,17-/m1/s1
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n/an/a 260n/an/an/an/a7.032



Bayer Intellectual Property GmbH

US Patent


Assay Description
Tyrosine kinase activity assay (NADH Read-Out)using human c-Met protein (Invitrogen, Carlsbad, Calif., USA). The amount of phosphorylated substrate ...


US Patent US8604028 (2013)


BindingDB Entry DOI: 10.7270/Q23T9FVT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM109201
PNG
(US8604028, 57)
Show SMILES CC1=NC(C(F)F)=C(C#N)C(C1[N+]#[C-])c1cc2c(N)nccc2o1
Show InChI InChI=1S/C16H11F2N5O/c1-7-13(21-2)12(9(6-19)14(23-7)15(17)18)11-5-8-10(24-11)3-4-22-16(8)20/h3-5,12-13,15H,1H3,(H2,20,22)
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n/an/a 37n/an/an/an/a7.032



Bayer Intellectual Property GmbH

US Patent


Assay Description
Tyrosine kinase activity assay (NADH Read-Out)using human c-Met protein (Invitrogen, Carlsbad, Calif., USA). The amount of phosphorylated substrate ...


US Patent US8604028 (2013)


BindingDB Entry DOI: 10.7270/Q23T9FVT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM103457
PNG
(US8551989, 2)
Show SMILES CC1=NC(C)=C(C#N)C(C1C#N)c1ccc2[nH]nc(SCc3ccccc3)c2c1
Show InChI InChI=1S/C23H19N5S/c1-14-19(11-24)22(20(12-25)15(2)26-14)17-8-9-21-18(10-17)23(28-27-21)29-13-16-6-4-3-5-7-16/h3-10,19,22H,13H2,1-2H3,(H,27,28)
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n/an/a 7n/an/an/an/a7.032



Bayer Intellectual Property GmbH

US Patent


Assay Description
Tyrosine kinase activity assay (NADH Read-Out) using c-Met receptor.


US Patent US8551989 (2013)


BindingDB Entry DOI: 10.7270/Q24F1PCX
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24462
PNG
(N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}...)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(C[C@@H](C)O)n(-c5ccccc5)c4=O)cc3F)ccnc2c1
Show InChI InChI=1S/C30H27FN4O5/c1-18(36)17-34-19(2)28(30(38)35(34)21-7-5-4-6-8-21)29(37)33-20-9-12-27(24(31)15-20)40-26-13-14-32-25-16-22(39-3)10-11-23(25)26/h4-16,18,36H,17H2,1-3H3,(H,33,37)/t18-/m1/s1
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PubMed
1 -50.9n/an/an/an/an/a7.422



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...


J Med Chem 51: 3688-91 (2008)


Article DOI: 10.1021/jm800401t
BindingDB Entry DOI: 10.7270/Q2FF3QNG
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24459
PNG
(N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}...)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)cc3F)ccnc2c1
Show InChI InChI=1S/C28H23FN4O4/c1-17-26(28(35)33(32(17)2)19-7-5-4-6-8-19)27(34)31-18-9-12-25(22(29)15-18)37-24-13-14-30-23-16-20(36-3)10-11-21(23)24/h4-16H,1-3H3,(H,31,34)
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1 -50.9n/an/an/an/an/a7.422



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...


J Med Chem 51: 3688-91 (2008)


Article DOI: 10.1021/jm800401t
BindingDB Entry DOI: 10.7270/Q2FF3QNG
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24460
PNG
(N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}...)
Show SMILES CCCn1c(C)c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)ccc34)c(F)c2)c(=O)n1-c1ccccc1
Show InChI InChI=1S/C30H27FN4O4/c1-4-16-34-19(2)28(30(37)35(34)21-8-6-5-7-9-21)29(36)33-20-10-13-27(24(31)17-20)39-26-14-15-32-25-18-22(38-3)11-12-23(25)26/h5-15,17-18H,4,16H2,1-3H3,(H,33,36)
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PubMed
1.02 -50.8n/an/an/an/an/a7.422



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...


J Med Chem 51: 3688-91 (2008)


Article DOI: 10.1021/jm800401t
BindingDB Entry DOI: 10.7270/Q2FF3QNG
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24463
PNG
(N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}...)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(C[C@H](C)O)n(-c5ccccc5)c4=O)cc3F)ccnc2c1
Show InChI InChI=1S/C30H27FN4O5/c1-18(36)17-34-19(2)28(30(38)35(34)21-7-5-4-6-8-21)29(37)33-20-9-12-27(24(31)15-20)40-26-13-14-32-25-16-22(39-3)10-11-23(25)26/h4-16,18,36H,17H2,1-3H3,(H,33,37)/t18-/m0/s1
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1.10 -50.6n/an/an/an/an/a7.422



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...


J Med Chem 51: 3688-91 (2008)


Article DOI: 10.1021/jm800401t
BindingDB Entry DOI: 10.7270/Q2FF3QNG
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24466
PNG
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)(C)O)n(-c5ccccc5)c4=O)nc3)ccnc2c1
Show InChI InChI=1S/C30H29N5O5/c1-19-27(29(37)35(20-8-6-5-7-9-20)34(19)18-30(2,3)38)28(36)33-26-13-11-22(17-32-26)40-25-14-15-31-24-16-21(39-4)10-12-23(24)25/h5-17,38H,18H2,1-4H3,(H,32,33,36)
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1.20 -50.4n/an/an/an/an/a7.422



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...


J Med Chem 51: 3688-91 (2008)


Article DOI: 10.1021/jm800401t
BindingDB Entry DOI: 10.7270/Q2FF3QNG
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24464
PNG
(N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}...)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)=O)n(-c5ccccc5)c4=O)cc3F)ccnc2c1
Show InChI InChI=1S/C30H25FN4O5/c1-18(36)17-34-19(2)28(30(38)35(34)21-7-5-4-6-8-21)29(37)33-20-9-12-27(24(31)15-20)40-26-13-14-32-25-16-22(39-3)10-11-23(25)26/h4-16H,17H2,1-3H3,(H,33,37)
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PubMed
1.30 -50.2n/an/an/an/an/a7.422



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...


J Med Chem 51: 3688-91 (2008)


Article DOI: 10.1021/jm800401t
BindingDB Entry DOI: 10.7270/Q2FF3QNG
More data for this
Ligand-Target Pair
Tyrosine Kinase c-Met


(Mus musculus)
BDBM24466
PNG
(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)(C)O)n(-c5ccccc5)c4=O)nc3)ccnc2c1
Show InChI InChI=1S/C30H29N5O5/c1-19-27(29(37)35(20-8-6-5-7-9-20)34(19)18-30(2,3)38)28(36)33-26-13-11-22(17-32-26)40-25-14-15-31-24-16-21(39-4)10-12-23(24)25/h5-17,38H,18H2,1-4H3,(H,32,33,36)
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PubMed
2 -49.2n/an/an/an/an/a7.422



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...


J Med Chem 51: 3688-91 (2008)


Article DOI: 10.1021/jm800401t
BindingDB Entry DOI: 10.7270/Q2FF3QNG
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24465
PNG
(N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}...)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)(C)O)n(-c5ccccc5)c4=O)cc3F)ccnc2c1
Show InChI InChI=1S/C31H29FN4O5/c1-19-28(30(38)36(21-8-6-5-7-9-21)35(19)18-31(2,3)39)29(37)34-20-10-13-27(24(32)16-20)41-26-14-15-33-25-17-22(40-4)11-12-23(25)26/h5-17,39H,18H2,1-4H3,(H,34,37)
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PubMed
2.70 -48.4n/an/an/an/an/a7.422



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...


J Med Chem 51: 3688-91 (2008)


Article DOI: 10.1021/jm800401t
BindingDB Entry DOI: 10.7270/Q2FF3QNG
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24461
PNG
(N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}...)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)C)n(-c5ccccc5)c4=O)cc3F)ccnc2c1
Show InChI InChI=1S/C31H29FN4O4/c1-19(2)18-35-20(3)29(31(38)36(35)22-8-6-5-7-9-22)30(37)34-21-10-13-28(25(32)16-21)40-27-14-15-33-26-17-23(39-4)11-12-24(26)27/h5-17,19H,18H2,1-4H3,(H,34,37)
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8 -45.7n/an/an/an/an/a7.422



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...


J Med Chem 51: 3688-91 (2008)


Article DOI: 10.1021/jm800401t
BindingDB Entry DOI: 10.7270/Q2FF3QNG
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24484
PNG
(4-{[6-(furan-2-yl)-[1,2,4]triazolo[4,3-a]pyridazin...)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3ccco3)ccnc2c1
Show InChI InChI=1S/C20H15N5O3/c1-26-13-4-5-14-16(11-13)21-9-8-17(14)28-12-20-23-22-19-7-6-15(24-25(19)20)18-3-2-10-27-18/h2-11H,12H2,1H3
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n/an/a 29n/an/an/an/a7.422



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. Mole...


J Med Chem 51: 2879-82 (2008)


Article DOI: 10.1021/jm800043g
BindingDB Entry DOI: 10.7270/Q29P2ZZ6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24483
PNG
(5-(3-{[(7-methoxyquinolin-4-yl)oxy]methyl}-[1,2,4]...)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3cc(C)ns3)ccnc2c1
Show InChI InChI=1S/C20H16N6O2S/c1-12-9-18(29-25-12)15-5-6-19-22-23-20(26(19)24-15)11-28-17-7-8-21-16-10-13(27-2)3-4-14(16)17/h3-10H,11H2,1-2H3
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n/an/a 3n/an/an/an/a7.422



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. Mole...


J Med Chem 51: 2879-82 (2008)


Article DOI: 10.1021/jm800043g
BindingDB Entry DOI: 10.7270/Q29P2ZZ6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24482
PNG
(7-methoxy-4-{[6-(4-methylthiophen-2-yl)-[1,2,4]tri...)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3cc(C)cs3)ccnc2c1
Show InChI InChI=1S/C21H17N5O2S/c1-13-9-19(29-12-13)16-5-6-20-23-24-21(26(20)25-16)11-28-18-7-8-22-17-10-14(27-2)3-4-15(17)18/h3-10,12H,11H2,1-2H3
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n/an/a 1n/an/an/an/a7.422



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. Mole...


J Med Chem 51: 2879-82 (2008)


Article DOI: 10.1021/jm800043g
BindingDB Entry DOI: 10.7270/Q29P2ZZ6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24481
PNG
(7-methoxy-4-{[6-(thiophen-3-yl)-[1,2,4]triazolo[4,...)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3ccsc3)ccnc2c1
Show InChI InChI=1S/C20H15N5O2S/c1-26-14-2-3-15-17(10-14)21-8-6-18(15)27-11-20-23-22-19-5-4-16(24-25(19)20)13-7-9-28-12-13/h2-10,12H,11H2,1H3
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n/an/a 4n/an/an/an/a7.422



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. Mole...


J Med Chem 51: 2879-82 (2008)


Article DOI: 10.1021/jm800043g
BindingDB Entry DOI: 10.7270/Q29P2ZZ6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24480
PNG
(7-methoxy-4-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,...)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3cccs3)ccnc2c1
Show InChI InChI=1S/C20H15N5O2S/c1-26-13-4-5-14-16(11-13)21-9-8-17(14)27-12-20-23-22-19-7-6-15(24-25(19)20)18-3-2-10-28-18/h2-11H,12H2,1H3
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n/an/a 2n/an/an/an/a7.422



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. Mole...


J Med Chem 51: 2879-82 (2008)


Article DOI: 10.1021/jm800043g
BindingDB Entry DOI: 10.7270/Q29P2ZZ6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24479
PNG
(2-chloro-4-(3-{[(7-methoxyquinolin-4-yl)oxy]methyl...)
Show SMILES CNC(=O)c1ccc(cc1Cl)-c1ccc2nnc(COc3ccnc4cc(OC)ccc34)n2n1
Show InChI InChI=1S/C24H19ClN6O3/c1-26-24(32)16-5-3-14(11-18(16)25)19-7-8-22-28-29-23(31(22)30-19)13-34-21-9-10-27-20-12-15(33-2)4-6-17(20)21/h3-12H,13H2,1-2H3,(H,26,32)
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n/an/a 1n/an/an/an/a7.422



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. Mole...


J Med Chem 51: 2879-82 (2008)


Article DOI: 10.1021/jm800043g
BindingDB Entry DOI: 10.7270/Q29P2ZZ6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24477
PNG
(4-(3-{[(7-methoxyquinolin-4-yl)oxy]methyl}-[1,2,4]...)
Show SMILES CNC(=O)c1ccc(cc1)-c1ccc2nnc(COc3ccnc4cc(OC)ccc34)n2n1
Show InChI InChI=1S/C24H20N6O3/c1-25-24(31)16-5-3-15(4-6-16)19-9-10-22-27-28-23(30(22)29-19)14-33-21-11-12-26-20-13-17(32-2)7-8-18(20)21/h3-13H,14H2,1-2H3,(H,25,31)
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n/an/a 6n/an/an/an/a7.422



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. Mole...


J Med Chem 51: 2879-82 (2008)


Article DOI: 10.1021/jm800043g
BindingDB Entry DOI: 10.7270/Q29P2ZZ6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24478
PNG
(2-fluoro-4-(3-{[(7-methoxyquinolin-4-yl)oxy]methyl...)
Show SMILES CNC(=O)c1ccc(cc1F)-c1ccc2nnc(COc3ccnc4cc(OC)ccc34)n2n1
Show InChI InChI=1S/C24H19FN6O3/c1-26-24(32)16-5-3-14(11-18(16)25)19-7-8-22-28-29-23(31(22)30-19)13-34-21-9-10-27-20-12-15(33-2)4-6-17(20)21/h3-12H,13H2,1-2H3,(H,26,32)
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n/an/a 3n/an/an/an/a7.422



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. Mole...


J Med Chem 51: 2879-82 (2008)


Article DOI: 10.1021/jm800043g
BindingDB Entry DOI: 10.7270/Q29P2ZZ6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24476
PNG
(7-methoxy-4-{[6-(3,4,5-trifluorophenyl)-[1,2,4]tri...)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3cc(F)c(F)c(F)c3)ccnc2c1
Show InChI InChI=1S/C22H14F3N5O2/c1-31-13-2-3-14-18(10-13)26-7-6-19(14)32-11-21-28-27-20-5-4-17(29-30(20)21)12-8-15(23)22(25)16(24)9-12/h2-10H,11H2,1H3
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n/an/a 4n/an/an/an/a7.422



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. Mole...


J Med Chem 51: 2879-82 (2008)


Article DOI: 10.1021/jm800043g
BindingDB Entry DOI: 10.7270/Q29P2ZZ6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24475
PNG
(4-{[6-(3,5-difluorophenyl)-[1,2,4]triazolo[4,3-a]p...)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3cc(F)cc(F)c3)ccnc2c1
Show InChI InChI=1S/C22H15F2N5O2/c1-30-16-2-3-17-19(11-16)25-7-6-20(17)31-12-22-27-26-21-5-4-18(28-29(21)22)13-8-14(23)10-15(24)9-13/h2-11H,12H2,1H3
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n/an/a 7n/an/an/an/a7.422



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. Mole...


J Med Chem 51: 2879-82 (2008)


Article DOI: 10.1021/jm800043g
BindingDB Entry DOI: 10.7270/Q29P2ZZ6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24474
PNG
(4-{[6-(3,4-difluorophenyl)-[1,2,4]triazolo[4,3-a]p...)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3ccc(F)c(F)c3)ccnc2c1
Show InChI InChI=1S/C22H15F2N5O2/c1-30-14-3-4-15-19(11-14)25-9-8-20(15)31-12-22-27-26-21-7-6-18(28-29(21)22)13-2-5-16(23)17(24)10-13/h2-11H,12H2,1H3
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n/an/a 9n/an/an/an/a7.422



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. Mole...


J Med Chem 51: 2879-82 (2008)


Article DOI: 10.1021/jm800043g
BindingDB Entry DOI: 10.7270/Q29P2ZZ6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24473
PNG
(4-{[6-(2-fluorophenyl)-[1,2,4]triazolo[4,3-a]pyrid...)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3ccccc3F)ccnc2c1
Show InChI InChI=1S/C22H16FN5O2/c1-29-14-6-7-16-19(12-14)24-11-10-20(16)30-13-22-26-25-21-9-8-18(27-28(21)22)15-4-2-3-5-17(15)23/h2-12H,13H2,1H3
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n/an/a 67n/an/an/an/a7.422



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. Mole...


J Med Chem 51: 2879-82 (2008)


Article DOI: 10.1021/jm800043g
BindingDB Entry DOI: 10.7270/Q29P2ZZ6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24472
PNG
(4-{[6-(3-fluorophenyl)-[1,2,4]triazolo[4,3-a]pyrid...)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3cccc(F)c3)ccnc2c1
Show InChI InChI=1S/C22H16FN5O2/c1-29-16-5-6-17-19(12-16)24-10-9-20(17)30-13-22-26-25-21-8-7-18(27-28(21)22)14-3-2-4-15(23)11-14/h2-12H,13H2,1H3
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n/an/a 7n/an/an/an/a7.422



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. Mole...


J Med Chem 51: 2879-82 (2008)


Article DOI: 10.1021/jm800043g
BindingDB Entry DOI: 10.7270/Q29P2ZZ6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24471
PNG
(4-{[6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-a]pyrid...)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3ccc(F)cc3)ccnc2c1
Show InChI InChI=1S/C22H16FN5O2/c1-29-16-6-7-17-19(12-16)24-11-10-20(17)30-13-22-26-25-21-9-8-18(27-28(21)22)14-2-4-15(23)5-3-14/h2-12H,13H2,1H3
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n/an/a 12n/an/an/an/a7.422



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. Mole...


J Med Chem 51: 2879-82 (2008)


Article DOI: 10.1021/jm800043g
BindingDB Entry DOI: 10.7270/Q29P2ZZ6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24470
PNG
(7-methoxy-4-({6-phenyl-[1,2,4]triazolo[4,3-a]pyrid...)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3ccccc3)ccnc2c1
Show InChI InChI=1S/C22H17N5O2/c1-28-16-7-8-17-19(13-16)23-12-11-20(17)29-14-22-25-24-21-10-9-18(26-27(21)22)15-5-3-2-4-6-15/h2-13H,14H2,1H3
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n/an/a 9n/an/an/an/a7.422



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. Mole...


J Med Chem 51: 2879-82 (2008)


Article DOI: 10.1021/jm800043g
BindingDB Entry DOI: 10.7270/Q29P2ZZ6
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24469
PNG
(4-({6-phenyl-[1,2,4]triazolo[3,4-a]pyridin-3-yl}me...)
Show SMILES Oc1ccc(Cc2nnc3ccc(cn23)-c2ccccc2)cc1
Show InChI InChI=1S/C19H15N3O/c23-17-9-6-14(7-10-17)12-19-21-20-18-11-8-16(13-22(18)19)15-4-2-1-3-5-15/h1-11,13,23H,12H2
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n/an/a 2.10E+3n/an/an/an/a7.422



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. Mole...


J Med Chem 51: 2879-82 (2008)


Article DOI: 10.1021/jm800043g
BindingDB Entry DOI: 10.7270/Q29P2ZZ6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24468
PNG
(4-({6-phenyl-[1,2,4]triazolo[4,3-a]pyrimidin-3-yl}...)
Show SMILES Oc1ccc(Cc2nnc3ncc(cn23)-c2ccccc2)cc1
Show InChI InChI=1S/C18H14N4O/c23-16-8-6-13(7-9-16)10-17-20-21-18-19-11-15(12-22(17)18)14-4-2-1-3-5-14/h1-9,11-12,23H,10H2
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n/an/a 610n/an/an/an/a7.422



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. Mole...


J Med Chem 51: 2879-82 (2008)


Article DOI: 10.1021/jm800043g
BindingDB Entry DOI: 10.7270/Q29P2ZZ6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24467
PNG
(4-({6-phenyl-[1,2,4]triazolo[4,3-a]pyridazin-3-yl}...)
Show SMILES Oc1ccc(Cc2nnc3ccc(nn23)-c2ccccc2)cc1
Show InChI InChI=1S/C18H14N4O/c23-15-8-6-13(7-9-15)12-18-20-19-17-11-10-16(21-22(17)18)14-4-2-1-3-5-14/h1-11,23H,12H2
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n/an/a 120n/an/an/an/a7.422



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. Mole...


J Med Chem 51: 2879-82 (2008)


Article DOI: 10.1021/jm800043g
BindingDB Entry DOI: 10.7270/Q29P2ZZ6
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24772
PNG
(2-[(4-fluorophenyl)amino]-5-[5-({6-methoxy-7-[3-(m...)
Show SMILES COc1cc2c(Oc3ccc(nc3)-c3cnc(Nc4ccc(F)cc4)n(C)c3=O)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C33H33FN6O5/c1-39-32(41)26(21-37-33(39)38-23-6-4-22(34)5-7-23)27-9-8-24(20-36-27)45-29-10-11-35-28-19-31(30(42-2)18-25(28)29)44-15-3-12-40-13-16-43-17-14-40/h4-11,18-21H,3,12-17H2,1-2H3,(H,37,38)
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3.40 -47.8n/an/an/an/an/a7.522



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...


J Med Chem 51: 5766-79 (2008)


Article DOI: 10.1021/jm8006189
BindingDB Entry DOI: 10.7270/Q23X84XN
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24769
PNG
(5-[3-fluoro-4-({6-methoxy-7-[3-(morpholin-4-yl)pro...)
Show SMILES COc1cc2c(Oc3ccc(cc3F)-c3cnc(Nc4ccc(F)cc4)n(C)c3=O)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H33F2N5O5/c1-40-33(42)26(21-38-34(40)39-24-7-5-23(35)6-8-24)22-4-9-30(27(36)18-22)46-29-10-11-37-28-20-32(31(43-2)19-25(28)29)45-15-3-12-41-13-16-44-17-14-41/h4-11,18-21H,3,12-17H2,1-2H3,(H,38,39)
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PubMed
4.90 -47.0n/an/an/an/an/a7.522



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...


J Med Chem 51: 5766-79 (2008)


Article DOI: 10.1021/jm8006189
BindingDB Entry DOI: 10.7270/Q23X84XN
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24751
PNG
(2-benzyl-5-[3-fluoro-4-({6-methoxy-7-[3-(morpholin...)
Show SMILES COc1cc2c(Oc3ccc(cc3F)-c3cnc(Cc4ccccc4)n(C)c3=O)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C35H35FN4O5/c1-39-34(19-24-7-4-3-5-8-24)38-23-27(35(39)41)25-9-10-31(28(36)20-25)45-30-11-12-37-29-22-33(32(42-2)21-26(29)30)44-16-6-13-40-14-17-43-18-15-40/h3-5,7-12,20-23H,6,13-19H2,1-2H3
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PubMed
8.90 -45.5n/an/an/an/an/a7.522



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...


J Med Chem 51: 5766-79 (2008)


Article DOI: 10.1021/jm8006189
BindingDB Entry DOI: 10.7270/Q23X84XN
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24754
PNG
(2-benzyl-5-[3-fluoro-4-({6-methoxy-7-[3-(4-methylp...)
Show SMILES COc1cc2c(Oc3ccc(cc3F)-c3cnc(Cc4ccccc4)n(C)c3=O)ccnc2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C36H38FN5O4/c1-40-15-17-42(18-16-40)14-7-19-45-34-23-30-27(22-33(34)44-3)31(12-13-38-30)46-32-11-10-26(21-29(32)37)28-24-39-35(41(2)36(28)43)20-25-8-5-4-6-9-25/h4-6,8-13,21-24H,7,14-20H2,1-3H3
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9.20 -45.4n/an/an/an/an/a7.522



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...


J Med Chem 51: 5766-79 (2008)


Article DOI: 10.1021/jm8006189
BindingDB Entry DOI: 10.7270/Q23X84XN
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24764
PNG
(5-[3-fluoro-4-({6-methoxy-7-[3-(morpholin-4-yl)pro...)
Show SMILES COc1cc2c(Oc3ccc(cc3F)-c3cnc(Cc4ccc(C)cc4)n(C)c3=O)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C36H37FN4O5/c1-24-5-7-25(8-6-24)19-35-39-23-28(36(42)40(35)2)26-9-10-32(29(37)20-26)46-31-11-12-38-30-22-34(33(43-3)21-27(30)31)45-16-4-13-41-14-17-44-18-15-41/h5-12,20-23H,4,13-19H2,1-3H3
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PubMed
9.60 -45.3n/an/an/an/an/a7.522



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...


J Med Chem 51: 5766-79 (2008)


Article DOI: 10.1021/jm8006189
BindingDB Entry DOI: 10.7270/Q23X84XN
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24752
PNG
(2-benzyl-5-[3-fluoro-4-({6-methoxy-7-[3-(pyrrolidi...)
Show SMILES COc1cc2c(Oc3ccc(cc3F)-c3cnc(Cc4ccccc4)n(C)c3=O)ccnc2cc1OCCCN1CCCC1
Show InChI InChI=1S/C35H35FN4O4/c1-39-34(19-24-9-4-3-5-10-24)38-23-27(35(39)41)25-11-12-31(28(36)20-25)44-30-13-14-37-29-22-33(32(42-2)21-26(29)30)43-18-8-17-40-15-6-7-16-40/h3-5,9-14,20-23H,6-8,15-19H2,1-2H3
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12 -44.8n/an/an/an/an/a7.522



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...


J Med Chem 51: 5766-79 (2008)


Article DOI: 10.1021/jm8006189
BindingDB Entry DOI: 10.7270/Q23X84XN
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24768
PNG
(5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophe...)
Show SMILES COc1cc2nccc(Oc3ccc(cc3F)-c3cnc(Nc4ccc(F)cc4)n(C)c3=O)c2cc1OC
Show InChI InChI=1S/C28H22F2N4O4/c1-34-27(35)20(15-32-28(34)33-18-7-5-17(29)6-8-18)16-4-9-24(21(30)12-16)38-23-10-11-31-22-14-26(37-3)25(36-2)13-19(22)23/h4-15H,1-3H3,(H,32,33)
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14 -44.4n/an/an/an/an/a7.522



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...


J Med Chem 51: 5766-79 (2008)


Article DOI: 10.1021/jm8006189
BindingDB Entry DOI: 10.7270/Q23X84XN
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24765
PNG
(5-[3-fluoro-4-({6-methoxy-7-[3-(morpholin-4-yl)pro...)
Show SMILES COc1cc2c(Oc3ccc(cc3F)-c3cnc(Cc4ccc(F)cc4)n(C)c3=O)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C35H34F2N4O5/c1-40-34(18-23-4-7-25(36)8-5-23)39-22-27(35(40)42)24-6-9-31(28(37)19-24)46-30-10-11-38-29-21-33(32(43-2)20-26(29)30)45-15-3-12-41-13-16-44-17-14-41/h4-11,19-22H,3,12-18H2,1-2H3
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17 -43.9n/an/an/an/an/a7.522



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...


J Med Chem 51: 5766-79 (2008)


Article DOI: 10.1021/jm8006189
BindingDB Entry DOI: 10.7270/Q23X84XN
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24755
PNG
(2-benzyl-5-[4-({7-[3-(4-ethylpiperazin-1-yl)propox...)
Show SMILES CCN1CCN(CCCOc2cc3nccc(Oc4ccc(cc4F)-c4cnc(Cc5ccccc5)n(C)c4=O)c3cc2OC)CC1
Show InChI InChI=1S/C37H40FN5O4/c1-4-42-16-18-43(19-17-42)15-8-20-46-35-24-31-28(23-34(35)45-3)32(13-14-39-31)47-33-12-11-27(22-30(33)38)29-25-40-36(41(2)37(29)44)21-26-9-6-5-7-10-26/h5-7,9-14,22-25H,4,8,15-21H2,1-3H3
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21 -43.4n/an/an/an/an/a7.522



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...


J Med Chem 51: 5766-79 (2008)


Article DOI: 10.1021/jm8006189
BindingDB Entry DOI: 10.7270/Q23X84XN
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24753
PNG
(2-benzyl-5-[3-fluoro-4-({6-methoxy-7-[3-(1H-1,2,4-...)
Show SMILES COc1cc2c(Oc3ccc(cc3F)-c3cnc(Cc4ccccc4)n(C)c3=O)ccnc2cc1OCCCn1cncn1
Show InChI InChI=1S/C33H29FN6O4/c1-39-32(15-22-7-4-3-5-8-22)37-19-25(33(39)41)23-9-10-29(26(34)16-23)44-28-11-12-36-27-18-31(30(42-2)17-24(27)28)43-14-6-13-40-21-35-20-38-40/h3-5,7-12,16-21H,6,13-15H2,1-2H3
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29 -42.6n/an/an/an/an/a7.522



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...


J Med Chem 51: 5766-79 (2008)


Article DOI: 10.1021/jm8006189
BindingDB Entry DOI: 10.7270/Q23X84XN
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24760
PNG
(N-[(5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluor...)
Show SMILES COc1cc2nccc(Oc3ccc(cc3F)-c3cnc(C(NC(=O)CN(C)C)c4ccccc4)n(C)c3=O)c2cc1OC
Show InChI InChI=1S/C33H32FN5O5/c1-38(2)19-30(40)37-31(20-9-7-6-8-10-20)32-36-18-23(33(41)39(32)3)21-11-12-27(24(34)15-21)44-26-13-14-35-25-17-29(43-5)28(42-4)16-22(25)26/h6-18,31H,19H2,1-5H3,(H,37,40)
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30 -42.5n/an/an/an/an/a7.522



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...


J Med Chem 51: 5766-79 (2008)


Article DOI: 10.1021/jm8006189
BindingDB Entry DOI: 10.7270/Q23X84XN
More data for this
Ligand-Target Pair
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