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Compile Data Set for Download or QSAR

Found 151 hits Enz. Inhib. hit(s) with Target = 'Hormone-sensitive lipase (HSL)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM141536
PNG
(US8921404, 1)
Show SMILES CC1CCN(CC1)C(=O)Oc1noc2cc(Cl)ccc12
Show InChI InChI=1S/C14H15ClN2O3/c1-9-4-6-17(7-5-9)14(18)19-13-11-3-2-10(15)8-12(11)20-16-13/h2-3,8-9H,4-7H2,1H3
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US Patent
n/an/a 120n/an/an/an/a7.037



Sanofi

US Patent


Assay Description
To prepare the substrate, 25-50 uCi of [3H]trioleoylglycerol (in toluene), 6.8 umol of unlabeled trioleoylglycerol and 0.6 mg of phospholipids (phosp...


US Patent US8921404 (2014)


BindingDB Entry DOI: 10.7270/Q24748KQ
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM141537
PNG
(US8921404, 2)
Show SMILES CC1CCN(CC1)C(=O)Oc1noc2ncccc12
Show InChI InChI=1S/C13H15N3O3/c1-9-4-7-16(8-5-9)13(17)18-12-10-3-2-6-14-11(10)19-15-12/h2-3,6,9H,4-5,7-8H2,1H3
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n/an/a 120n/an/an/an/a7.037



Sanofi

US Patent


Assay Description
To prepare the substrate, 25-50 uCi of [3H]trioleoylglycerol (in toluene), 6.8 umol of unlabeled trioleoylglycerol and 0.6 mg of phospholipids (phosp...


US Patent US8921404 (2014)


BindingDB Entry DOI: 10.7270/Q24748KQ
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM141538
PNG
(US8921404, 3)
Show SMILES FC(F)(F)C1CCN(CC1)C(=O)Oc1noc2cc(Cl)ccc12
Show InChI InChI=1S/C14H12ClF3N2O3/c15-9-1-2-10-11(7-9)23-19-12(10)22-13(21)20-5-3-8(4-6-20)14(16,17)18/h1-2,7-8H,3-6H2
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n/an/a 100n/an/an/an/a7.037



Sanofi

US Patent


Assay Description
To prepare the substrate, 25-50 uCi of [3H]trioleoylglycerol (in toluene), 6.8 umol of unlabeled trioleoylglycerol and 0.6 mg of phospholipids (phosp...


US Patent US8921404 (2014)


BindingDB Entry DOI: 10.7270/Q24748KQ
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM141539
PNG
(US8921404, 4)
Show SMILES CC1CCN(CC1)C(=O)Oc1nsc2ncccc12
Show InChI InChI=1S/C13H15N3O2S/c1-9-4-7-16(8-5-9)13(17)18-11-10-3-2-6-14-12(10)19-15-11/h2-3,6,9H,4-5,7-8H2,1H3
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n/an/a 100n/an/an/an/a7.037



Sanofi

US Patent


Assay Description
To prepare the substrate, 25-50 uCi of [3H]trioleoylglycerol (in toluene), 6.8 umol of unlabeled trioleoylglycerol and 0.6 mg of phospholipids (phosp...


US Patent US8921404 (2014)


BindingDB Entry DOI: 10.7270/Q24748KQ
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM141540
PNG
(US8921404, 5)
Show SMILES CC1CCN(CC1)C(=O)Oc1nsc2ccccc12
Show InChI InChI=1S/C14H16N2O2S/c1-10-6-8-16(9-7-10)14(17)18-13-11-4-2-3-5-12(11)19-15-13/h2-5,10H,6-9H2,1H3
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n/an/a 100n/an/an/an/a7.037



Sanofi

US Patent


Assay Description
To prepare the substrate, 25-50 uCi of [3H]trioleoylglycerol (in toluene), 6.8 umol of unlabeled trioleoylglycerol and 0.6 mg of phospholipids (phosp...


US Patent US8921404 (2014)


BindingDB Entry DOI: 10.7270/Q24748KQ
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM141543
PNG
(US8921404, 10)
Show SMILES CC1CCN(CC1)C(=O)Oc1noc2nc(Cl)ccc12
Show InChI InChI=1S/C13H14ClN3O3/c1-8-4-6-17(7-5-8)13(18)19-12-9-2-3-10(14)15-11(9)20-16-12/h2-3,8H,4-7H2,1H3
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n/an/a 670n/an/an/an/a7.037



Sanofi

US Patent


Assay Description
To prepare the substrate, 25-50 uCi of [3H]trioleoylglycerol (in toluene), 6.8 umol of unlabeled trioleoylglycerol and 0.6 mg of phospholipids (phosp...


US Patent US8921404 (2014)


BindingDB Entry DOI: 10.7270/Q24748KQ
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM141544
PNG
(US8921404, 11)
Show SMILES CC1CCN(CC1)C(=O)Oc1noc2nc(C)ccc12
Show InChI InChI=1S/C14H17N3O3/c1-9-5-7-17(8-6-9)14(18)19-13-11-4-3-10(2)15-12(11)20-16-13/h3-4,9H,5-8H2,1-2H3
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n/an/a 260n/an/an/an/a7.037



Sanofi

US Patent


Assay Description
To prepare the substrate, 25-50 uCi of [3H]trioleoylglycerol (in toluene), 6.8 umol of unlabeled trioleoylglycerol and 0.6 mg of phospholipids (phosp...


US Patent US8921404 (2014)


BindingDB Entry DOI: 10.7270/Q24748KQ
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50064422
PNG
(CHEMBL3401162)
Show SMILES CCCCCCCCCCCCCCCCO[P@]1(=O)OC[C@@H]2COC(=O)C2=C(C)O1
Show InChI InChI=1S/C23H41O6P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27-30(25)28-19-21-18-26-23(24)22(21)20(2)29-30/h21H,3-19H2,1-2H3/t21-,30+/m0/s1
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40n/an/an/an/an/an/an/an/a



University of Missouri St. Louis

Curated by ChEMBL


Assay Description
Irreversible inhibition of rat hormone sensitive lipase assessed as relative residual activity by kinetic analysis


Bioorg Med Chem 23: 944-52 (2015)


Article DOI: 10.1016/j.bmc.2015.01.028
BindingDB Entry DOI: 10.7270/Q23X88BP
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50064408
PNG
(CHEMBL3401171)
Show SMILES CCCCCCCCCCCCCCCC[C@H]1CC[P@@](=O)(OC)OC(C)=C1C(=O)OC
Show InChI InChI=1S/C25H47O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23-20-21-31(27,29-4)30-22(2)24(23)25(26)28-3/h23H,5-21H2,1-4H3/t23-,31+/m0/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



University of Missouri St. Louis

Curated by ChEMBL


Assay Description
Inhibition of rat hormone sensitive lipase assessed as oleic acid release from [3H]triolein by scintillation counting


Bioorg Med Chem 23: 944-52 (2015)


Article DOI: 10.1016/j.bmc.2015.01.028
BindingDB Entry DOI: 10.7270/Q23X88BP
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50064409
PNG
(CHEMBL2179367)
Show SMILES CCCCCCCCCCCCCCCC[C@@H]1CC[P@@](=O)(OC)OC(C)=C1C(=O)OC
Show InChI InChI=1S/C25H47O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23-20-21-31(27,29-4)30-22(2)24(23)25(26)28-3/h23H,5-21H2,1-4H3/t23-,31-/m1/s1
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n/an/a 6.00E+4n/an/an/an/an/an/a



University of Missouri St. Louis

Curated by ChEMBL


Assay Description
Inhibition of rat hormone sensitive lipase assessed as oleic acid release from [3H]triolein by scintillation counting


Bioorg Med Chem 23: 944-52 (2015)


Article DOI: 10.1016/j.bmc.2015.01.028
BindingDB Entry DOI: 10.7270/Q23X88BP
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50064410
PNG
(CHEMBL3401170)
Show SMILES CCCCCCCCCCCC[C@H]1CC[P@@](=O)(OC)OC(C)=C1C(=O)OC
Show InChI InChI=1S/C21H39O5P/c1-5-6-7-8-9-10-11-12-13-14-15-19-16-17-27(23,25-4)26-18(2)20(19)21(22)24-3/h19H,5-17H2,1-4H3/t19-,27+/m0/s1
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n/an/a 1.35E+4n/an/an/an/an/an/a



University of Missouri St. Louis

Curated by ChEMBL


Assay Description
Inhibition of rat hormone sensitive lipase assessed as oleic acid release from [3H]triolein by scintillation counting


Bioorg Med Chem 23: 944-52 (2015)


Article DOI: 10.1016/j.bmc.2015.01.028
BindingDB Entry DOI: 10.7270/Q23X88BP
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50064411
PNG
(CHEMBL2179369)
Show SMILES CCCCCCCCCCCC[C@@H]1CC[P@@](=O)(OC)OC(C)=C1C(=O)OC
Show InChI InChI=1S/C21H39O5P/c1-5-6-7-8-9-10-11-12-13-14-15-19-16-17-27(23,25-4)26-18(2)20(19)21(22)24-3/h19H,5-17H2,1-4H3/t19-,27-/m1/s1
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n/an/a 3.50E+4n/an/an/an/an/an/a



University of Missouri St. Louis

Curated by ChEMBL


Assay Description
Inhibition of rat hormone sensitive lipase assessed as oleic acid release from [3H]triolein by scintillation counting


Bioorg Med Chem 23: 944-52 (2015)


Article DOI: 10.1016/j.bmc.2015.01.028
BindingDB Entry DOI: 10.7270/Q23X88BP
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50064412
PNG
(CHEMBL3401169)
Show SMILES CCCCCCCCCCCCCCCCOP1(=O)OC(C)=C(CCC1(F)F)C(=O)OC
Show InChI InChI=1S/C24H43F2O5P/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20-30-32(28)24(25,26)19-18-22(21(2)31-32)23(27)29-3/h4-20H2,1-3H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Missouri St. Louis

Curated by ChEMBL


Assay Description
Inhibition of rat hormone sensitive lipase assessed as oleic acid release from [3H]triolein by scintillation counting


Bioorg Med Chem 23: 944-52 (2015)


Article DOI: 10.1016/j.bmc.2015.01.028
BindingDB Entry DOI: 10.7270/Q23X88BP
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50064413
PNG
(CHEMBL3401168)
Show SMILES CCCCCCCCCCCCCCCCOP1(=O)OCCC(C(=O)OC)=C(C)O1
Show InChI InChI=1S/C23H43O6P/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-19-27-30(25)28-20-18-22(21(2)29-30)23(24)26-3/h4-20H2,1-3H3
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n/an/a 60n/an/an/an/an/an/a



University of Missouri St. Louis

Curated by ChEMBL


Assay Description
Inhibition of rat hormone sensitive lipase assessed as oleic acid release from [3H]triolein by scintillation counting


Bioorg Med Chem 23: 944-52 (2015)


Article DOI: 10.1016/j.bmc.2015.01.028
BindingDB Entry DOI: 10.7270/Q23X88BP
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50064414
PNG
(CHEMBL3401167)
Show SMILES CCCCCCCCCCCCCCCCO[P@]1(=O)CC[C@H]2COC(=O)C2=C(C)O1
Show InChI InChI=1S/C24H43O5P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18-28-30(26)19-17-22-20-27-24(25)23(22)21(2)29-30/h22H,3-20H2,1-2H3/t22-,30+/m0/s1
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n/an/a 360n/an/an/an/an/an/a



University of Missouri St. Louis

Curated by ChEMBL


Assay Description
Inhibition of rat hormone sensitive lipase assessed as oleic acid release from [3H]triolein by scintillation counting


Bioorg Med Chem 23: 944-52 (2015)


Article DOI: 10.1016/j.bmc.2015.01.028
BindingDB Entry DOI: 10.7270/Q23X88BP
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50064415
PNG
(CHEMBL3401166)
Show SMILES CCCCCCCCCCCCCCCCO[P@]1(=O)CC[C@@H]2COC(=O)C2=C(C)O1
Show InChI InChI=1S/C24H43O5P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18-28-30(26)19-17-22-20-27-24(25)23(22)21(2)29-30/h22H,3-20H2,1-2H3/t22-,30-/m1/s1
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n/an/a 6.90E+3n/an/an/an/an/an/a



University of Missouri St. Louis

Curated by ChEMBL


Assay Description
Inhibition of rat hormone sensitive lipase assessed as oleic acid release from [3H]triolein by scintillation counting


Bioorg Med Chem 23: 944-52 (2015)


Article DOI: 10.1016/j.bmc.2015.01.028
BindingDB Entry DOI: 10.7270/Q23X88BP
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50064416
PNG
(CHEMBL3401165)
Show SMILES CCCCCCCCCCCCCCCO[P@]1(=O)CC[C@H]2COC(=O)C2=C(C)O1
Show InChI InChI=1S/C23H41O5P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-17-27-29(25)18-16-21-19-26-23(24)22(21)20(2)28-29/h21H,3-19H2,1-2H3/t21-,29+/m0/s1
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n/an/a 470n/an/an/an/an/an/a



University of Missouri St. Louis

Curated by ChEMBL


Assay Description
Inhibition of rat hormone sensitive lipase assessed as oleic acid release from [3H]triolein by scintillation counting


Bioorg Med Chem 23: 944-52 (2015)


Article DOI: 10.1016/j.bmc.2015.01.028
BindingDB Entry DOI: 10.7270/Q23X88BP
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50064418
PNG
(CHEMBL3401164)
Show SMILES CCCCCCCCCCCCCCCO[P@]1(=O)CC[C@@H]2COC(=O)C2=C(C)O1
Show InChI InChI=1S/C23H41O5P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-17-27-29(25)18-16-21-19-26-23(24)22(21)20(2)28-29/h21H,3-19H2,1-2H3/t21-,29-/m1/s1
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n/an/a 450n/an/an/an/an/an/a



University of Missouri St. Louis

Curated by ChEMBL


Assay Description
Inhibition of rat hormone sensitive lipase assessed as oleic acid release from [3H]triolein by scintillation counting


Bioorg Med Chem 23: 944-52 (2015)


Article DOI: 10.1016/j.bmc.2015.01.028
BindingDB Entry DOI: 10.7270/Q23X88BP
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50064421
PNG
(CHEMBL3401163)
Show SMILES CCCCCCCCCCCCCCCCO[P@]1(=O)OC[C@H]2COC(=O)C2=C(C)O1
Show InChI InChI=1S/C23H41O6P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27-30(25)28-19-21-18-26-23(24)22(21)20(2)29-30/h21H,3-19H2,1-2H3/t21-,30-/m1/s1
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n/an/a 420n/an/an/an/an/an/a



University of Missouri St. Louis

Curated by ChEMBL


Assay Description
Inhibition of rat hormone sensitive lipase assessed as oleic acid release from [3H]triolein by scintillation counting


Bioorg Med Chem 23: 944-52 (2015)


Article DOI: 10.1016/j.bmc.2015.01.028
BindingDB Entry DOI: 10.7270/Q23X88BP
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50064422
PNG
(CHEMBL3401162)
Show SMILES CCCCCCCCCCCCCCCCO[P@]1(=O)OC[C@@H]2COC(=O)C2=C(C)O1
Show InChI InChI=1S/C23H41O6P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27-30(25)28-19-21-18-26-23(24)22(21)20(2)29-30/h21H,3-19H2,1-2H3/t21-,30+/m0/s1
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n/an/a 25n/an/an/an/an/an/a



University of Missouri St. Louis

Curated by ChEMBL


Assay Description
Inhibition of rat hormone sensitive lipase assessed as oleic acid release from [3H]triolein by scintillation counting


Bioorg Med Chem 23: 944-52 (2015)


Article DOI: 10.1016/j.bmc.2015.01.028
BindingDB Entry DOI: 10.7270/Q23X88BP
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50064423
PNG
(CHEMBL3401161)
Show SMILES CCCCCCCCCCCCCCCO[P@]1(=O)OC[C@H]2COC(=O)C2=C(C)O1
Show InChI InChI=1S/C22H39O6P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-26-29(24)27-18-20-17-25-22(23)21(20)19(2)28-29/h20H,3-18H2,1-2H3/t20-,29-/m1/s1
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n/an/a 75n/an/an/an/an/an/a



University of Missouri St. Louis

Curated by ChEMBL


Assay Description
Inhibition of rat hormone sensitive lipase assessed as oleic acid release from [3H]triolein by scintillation counting


Bioorg Med Chem 23: 944-52 (2015)


Article DOI: 10.1016/j.bmc.2015.01.028
BindingDB Entry DOI: 10.7270/Q23X88BP
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50064425
PNG
(CHEMBL3401160)
Show SMILES CCCCCCCCCCCCCCCO[P@]1(=O)OC[C@@H]2COC(=O)C2=C(C)O1
Show InChI InChI=1S/C22H39O6P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-26-29(24)27-18-20-17-25-22(23)21(20)19(2)28-29/h20H,3-18H2,1-2H3/t20-,29+/m0/s1
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n/an/a 900n/an/an/an/an/an/a



University of Missouri St. Louis

Curated by ChEMBL


Assay Description
Inhibition of rat hormone sensitive lipase assessed as oleic acid release from [3H]triolein by scintillation counting


Bioorg Med Chem 23: 944-52 (2015)


Article DOI: 10.1016/j.bmc.2015.01.028
BindingDB Entry DOI: 10.7270/Q23X88BP
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50308513
PNG
((3R,8aR)-3-Methoxy-5-methyl-3-oxo-8,8a-dihydro-1H-...)
Show SMILES CO[P@@]1(=O)CC[C@H]2COC(=O)C2=C(C)O1
Show InChI InChI=1S/C9H13O5P/c1-6-8-7(5-13-9(8)10)3-4-15(11,12-2)14-6/h7H,3-5H2,1-2H3/t7-,15-/m0/s1
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n/an/a 1.00E+5n/an/an/an/an/an/a



University of Missouri St. Louis

Curated by ChEMBL


Assay Description
Inhibition of rat hormone sensitive lipase assessed as oleic acid release from [3H]triolein by scintillation counting


Bioorg Med Chem 23: 944-52 (2015)


Article DOI: 10.1016/j.bmc.2015.01.028
BindingDB Entry DOI: 10.7270/Q23X88BP
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50308520
PNG
(CHEMBL603622 | cyclophostin)
Show SMILES CO[P@]1(=O)OC[C@H]2COC(=O)C2=C(C)O1
Show InChI InChI=1S/C8H11O6P/c1-5-7-6(3-12-8(7)9)4-13-15(10,11-2)14-5/h6H,3-4H2,1-2H3/t6-,15-/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Missouri St. Louis

Curated by ChEMBL


Assay Description
Inhibition of rat hormone sensitive lipase assessed as oleic acid release from [3H]triolein by scintillation counting


Bioorg Med Chem 23: 944-52 (2015)


Article DOI: 10.1016/j.bmc.2015.01.028
BindingDB Entry DOI: 10.7270/Q23X88BP
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50064426
PNG
(CHEMBL3401159)
Show SMILES CO[P@]1(=O)OC[C@@H]2COC(=O)C2=C(C)O1
Show InChI InChI=1S/C8H11O6P/c1-5-7-6(3-12-8(7)9)4-13-15(10,11-2)14-5/h6H,3-4H2,1-2H3/t6-,15+/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Missouri St. Louis

Curated by ChEMBL


Assay Description
Inhibition of rat hormone sensitive lipase assessed as oleic acid release from [3H]triolein by scintillation counting


Bioorg Med Chem 23: 944-52 (2015)


Article DOI: 10.1016/j.bmc.2015.01.028
BindingDB Entry DOI: 10.7270/Q23X88BP
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50064427
PNG
(CHEMBL3401172)
Show SMILES CCCCCCCCCCCCCCCCCC[C@H]1CC[P@@](=O)(OC)OC(C)=C1C(=O)OC
Show InChI InChI=1S/C27H51O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-22-23-33(29,31-4)32-24(2)26(25)27(28)30-3/h25H,5-23H2,1-4H3/t25-,33+/m0/s1
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n/an/a 2.70E+4n/an/an/an/an/an/a



University of Missouri St. Louis

Curated by ChEMBL


Assay Description
Inhibition of rat hormone sensitive lipase assessed as oleic acid release from [3H]triolein by scintillation counting


Bioorg Med Chem 23: 944-52 (2015)


Article DOI: 10.1016/j.bmc.2015.01.028
BindingDB Entry DOI: 10.7270/Q23X88BP
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50064428
PNG
(CHEMBL2179365)
Show SMILES CCCCCCCCCCCCCCCCCC[C@@H]1CC[P@@](=O)(OC)OC(C)=C1C(=O)OC
Show InChI InChI=1S/C27H51O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-22-23-33(29,31-4)32-24(2)26(25)27(28)30-3/h25H,5-23H2,1-4H3/t25-,33-/m1/s1
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University of Missouri St. Louis

Curated by ChEMBL


Assay Description
Inhibition of rat hormone sensitive lipase assessed as oleic acid release from [3H]triolein by scintillation counting


Bioorg Med Chem 23: 944-52 (2015)


Article DOI: 10.1016/j.bmc.2015.01.028
BindingDB Entry DOI: 10.7270/Q23X88BP
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50147250
PNG
(4-(4-Chloro-benzenesulfonyl)-3-methyl-2-(piperidin...)
Show SMILES Cc1c(c(=O)on1C(=O)N1CCCCC1)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C16H17ClN2O5S/c1-11-14(25(22,23)13-7-5-12(17)6-8-13)15(20)24-19(11)16(21)18-9-3-2-4-10-18/h5-8H,2-4,9-10H2,1H3
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n/an/a 35n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay


J Med Chem 51: 6478-94 (2008)


Article DOI: 10.1021/jm800718k
BindingDB Entry DOI: 10.7270/Q23778KJ
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50147275
PNG
(4-Isopropyl-3-methyl-5-oxo-5H-isoxazole-2-carboxyl...)
Show SMILES CC(C)c1c(C)n(oc1=O)C(=O)NC(C)(C)C
Show InChI InChI=1S/C12H20N2O3/c1-7(2)9-8(3)14(17-10(9)15)11(16)13-12(4,5)6/h7H,1-6H3,(H,13,16)
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n/an/a>1.00E+3n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay


J Med Chem 51: 6478-94 (2008)


Article DOI: 10.1021/jm800718k
BindingDB Entry DOI: 10.7270/Q23778KJ
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50147290
PNG
(1-(4-Isopropyl-3-methyl-5-oxo-5H-isoxazole-2-carbo...)
Show SMILES CCN(CC)C(=O)C1CCCN(C1)C(=O)n1oc(=O)c(C(C)C)c1C
Show InChI InChI=1S/C18H29N3O4/c1-6-19(7-2)16(22)14-9-8-10-20(11-14)18(24)21-13(5)15(12(3)4)17(23)25-21/h12,14H,6-11H2,1-5H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay


J Med Chem 51: 6478-94 (2008)


Article DOI: 10.1021/jm800718k
BindingDB Entry DOI: 10.7270/Q23778KJ
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50147316
PNG
(4-Isopropyl-3-methyl-2-(piperazine-1-carbonyl)-2H-...)
Show SMILES CC(C)c1c(C)n(oc1=O)C(=O)N1CCNCC1
Show InChI InChI=1S/C12H19N3O3/c1-8(2)10-9(3)15(18-11(10)16)12(17)14-6-4-13-5-7-14/h8,13H,4-7H2,1-3H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay


J Med Chem 51: 6478-94 (2008)


Article DOI: 10.1021/jm800718k
BindingDB Entry DOI: 10.7270/Q23778KJ
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50253012
PNG
(2-(indoline-1-carbonyl)-4-isopropyl-3-methylisoxaz...)
Show SMILES CC(C)c1c(C)n(oc1=O)C(=O)N1CCc2ccccc12
Show InChI InChI=1S/C16H18N2O3/c1-10(2)14-11(3)18(21-15(14)19)16(20)17-9-8-12-6-4-5-7-13(12)17/h4-7,10H,8-9H2,1-3H3
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University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay


J Med Chem 51: 6478-94 (2008)


Article DOI: 10.1021/jm800718k
BindingDB Entry DOI: 10.7270/Q23778KJ
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50147292
PNG
(4-Isopropyl-3-methyl-5-oxo-5H-isoxazole-2-carboxyl...)
Show SMILES CC(C)c1c(C)n(oc1=O)C(=O)N(C)CC(N)=O
Show InChI InChI=1S/C11H17N3O4/c1-6(2)9-7(3)14(18-10(9)16)11(17)13(4)5-8(12)15/h6H,5H2,1-4H3,(H2,12,15)
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n/an/a>1.00E+3n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay


J Med Chem 51: 6478-94 (2008)


Article DOI: 10.1021/jm800718k
BindingDB Entry DOI: 10.7270/Q23778KJ
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50147252
PNG
(4-Isopropyl-3-methyl-5-oxo-5H-isoxazole-2-carboxyl...)
Show SMILES CC(C)c1c(C)n(oc1=O)C(=O)N(C)CCC#N
Show InChI InChI=1S/C12H17N3O3/c1-8(2)10-9(3)15(18-11(10)16)12(17)14(4)7-5-6-13/h8H,5,7H2,1-4H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay


J Med Chem 51: 6478-94 (2008)


Article DOI: 10.1021/jm800718k
BindingDB Entry DOI: 10.7270/Q23778KJ
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50147308
PNG
(4-Isopropyl-3-methyl-5-oxo-5H-isoxazole-2-carboxyl...)
Show SMILES CC(C)c1c(C)n(oc1=O)C(=O)Nc1ccccc1
Show InChI InChI=1S/C14H16N2O3/c1-9(2)12-10(3)16(19-13(12)17)14(18)15-11-7-5-4-6-8-11/h4-9H,1-3H3,(H,15,18)
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n/an/a>1.00E+3n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay


J Med Chem 51: 6478-94 (2008)


Article DOI: 10.1021/jm800718k
BindingDB Entry DOI: 10.7270/Q23778KJ
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50147233
PNG
(2-(4-Hydroxy-4-phenyl-piperidine-1-carbonyl)-4-iso...)
Show SMILES CC(C)c1c(C)n(oc1=O)C(=O)N1CCC(O)(CC1)c1ccccc1
Show InChI InChI=1S/C19H24N2O4/c1-13(2)16-14(3)21(25-17(16)22)18(23)20-11-9-19(24,10-12-20)15-7-5-4-6-8-15/h4-8,13,24H,9-12H2,1-3H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay


J Med Chem 51: 6478-94 (2008)


Article DOI: 10.1021/jm800718k
BindingDB Entry DOI: 10.7270/Q23778KJ
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50147311
PNG
(1-(4-Isopropyl-3-methyl-5-oxo-5H-isoxazole-2-carbo...)
Show SMILES CC(C)c1c(C)n(oc1=O)C(=O)N1CCC(CC1)C(=O)N(C)C
Show InChI InChI=1S/C16H25N3O4/c1-10(2)13-11(3)19(23-15(13)21)16(22)18-8-6-12(7-9-18)14(20)17(4)5/h10,12H,6-9H2,1-5H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay


J Med Chem 51: 6478-94 (2008)


Article DOI: 10.1021/jm800718k
BindingDB Entry DOI: 10.7270/Q23778KJ
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50253286
PNG
(1-(4-butoxyphenoxy)-2-nitro-4-(trifluoromethyl)ben...)
Show SMILES CCCCOc1ccc(Oc2ccc(cc2[N+]([O-])=O)C(F)(F)F)cc1
Show InChI InChI=1S/C17H16F3NO4/c1-2-3-10-24-13-5-7-14(8-6-13)25-16-9-4-12(17(18,19)20)11-15(16)21(22)23/h4-9,11H,2-3,10H2,1H3
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n/an/a 210n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay


J Med Chem 51: 6478-94 (2008)


Article DOI: 10.1021/jm800718k
BindingDB Entry DOI: 10.7270/Q23778KJ
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50134035
PNG
(BENZYL BENZOATE | CHEMBL1239)
Show SMILES O=C(OCc1ccccc1)c1ccccc1
Show InChI InChI=1S/C14H12O2/c15-14(13-9-5-2-6-10-13)16-11-12-7-3-1-4-8-12/h1-10H,11H2
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n/an/a 1.10E+3n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay


J Med Chem 51: 6478-94 (2008)


Article DOI: 10.1021/jm800718k
BindingDB Entry DOI: 10.7270/Q23778KJ
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50009860
PNG
(2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(...)
Show SMILES COc1ccc2cc(ccc2c1)C(C)C(O)=O
Show InChI InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)
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n/an/a 1.20E+3n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay


J Med Chem 51: 6478-94 (2008)


Article DOI: 10.1021/jm800718k
BindingDB Entry DOI: 10.7270/Q23778KJ
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50253134
PNG
((2-hydroxy-4-methoxyphenyl)(phenyl)methanone | 2-B...)
Show SMILES COc1ccc(C(=O)c2ccccc2)c(O)c1
Show InChI InChI=1S/C14H12O3/c1-17-11-7-8-12(13(15)9-11)14(16)10-5-3-2-4-6-10/h2-9,15H,1H3
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n/an/a 3.25E+3n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay


J Med Chem 51: 6478-94 (2008)


Article DOI: 10.1021/jm800718k
BindingDB Entry DOI: 10.7270/Q23778KJ
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50253090
PNG
(2-((Ethylthio)methyl)phenol methylcarbamate | 2-((...)
Show SMILES CCSCc1ccccc1OC(=O)NC
Show InChI InChI=1S/C11H15NO2S/c1-3-15-8-9-6-4-5-7-10(9)14-11(13)12-2/h4-7H,3,8H2,1-2H3,(H,12,13)
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n/an/a 370n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay


J Med Chem 51: 6478-94 (2008)


Article DOI: 10.1021/jm800718k
BindingDB Entry DOI: 10.7270/Q23778KJ
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50253063
PNG
(Bifenox | CHEMBL449928)
Show SMILES COC(=O)c1cc(Oc2ccc(Cl)cc2Cl)ccc1[N+]([O-])=O
Show InChI InChI=1S/C14H9Cl2NO5/c1-21-14(18)10-7-9(3-4-12(10)17(19)20)22-13-5-2-8(15)6-11(13)16/h2-7H,1H3
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n/an/a 430n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay


J Med Chem 51: 6478-94 (2008)


Article DOI: 10.1021/jm800718k
BindingDB Entry DOI: 10.7270/Q23778KJ
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50253013
PNG
(2-(3-methoxybenzylthio)-2-phenylacetic acid | CHEM...)
Show SMILES COc1cccc(CSC(C(O)=O)c2ccccc2)c1
Show InChI InChI=1S/C16H16O3S/c1-19-14-9-5-6-12(10-14)11-20-15(16(17)18)13-7-3-2-4-8-13/h2-10,15H,11H2,1H3,(H,17,18)
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n/an/a 510n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay


J Med Chem 51: 6478-94 (2008)


Article DOI: 10.1021/jm800718k
BindingDB Entry DOI: 10.7270/Q23778KJ
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50252969
PNG
(2-(benzylthio)-5-(2-hydroxyethyl)-6-p-tolylpyrimid...)
Show SMILES Cc1ccc(cc1)-c1nc(SCc2ccccc2)[nH]c(=O)c1CCO
Show InChI InChI=1S/C20H20N2O2S/c1-14-7-9-16(10-8-14)18-17(11-12-23)19(24)22-20(21-18)25-13-15-5-3-2-4-6-15/h2-10,23H,11-13H2,1H3,(H,21,22,24)
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n/an/a 2.98E+3n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay


J Med Chem 51: 6478-94 (2008)


Article DOI: 10.1021/jm800718k
BindingDB Entry DOI: 10.7270/Q23778KJ
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50253287
PNG
(CHEMBL492678 | dimethyl 1-(2-(1H-indol-3-yl)ethyl)...)
Show SMILES COC(=O)c1nnn(CCc2c[nH]c3ccccc23)c1C(=O)OC
Show InChI InChI=1S/C16H16N4O4/c1-23-15(21)13-14(16(22)24-2)20(19-18-13)8-7-10-9-17-12-6-4-3-5-11(10)12/h3-6,9,17H,7-8H2,1-2H3
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n/an/a 5.00E+3n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay


J Med Chem 51: 6478-94 (2008)


Article DOI: 10.1021/jm800718k
BindingDB Entry DOI: 10.7270/Q23778KJ
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50147271
PNG
(4-Isopropyl-3-methyl-5-oxo-5H-isoxazole-2-carboxyl...)
Show SMILES CC(C)c1c(C)n(oc1=O)C(=O)N(C)c1ccccc1
Show InChI InChI=1S/C15H18N2O3/c1-10(2)13-11(3)17(20-14(13)18)15(19)16(4)12-8-6-5-7-9-12/h5-10H,1-4H3
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n/an/a 7n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay


J Med Chem 51: 6478-94 (2008)


Article DOI: 10.1021/jm800718k
BindingDB Entry DOI: 10.7270/Q23778KJ
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50147294
PNG
(4-Isopropyl-3-methyl-5-oxo-5H-isoxazole-2-carboxyl...)
Show SMILES CC(C)c1c(C)n(oc1=O)C(=O)N(C)CCc1ccccc1
Show InChI InChI=1S/C17H22N2O3/c1-12(2)15-13(3)19(22-16(15)20)17(21)18(4)11-10-14-8-6-5-7-9-14/h5-9,12H,10-11H2,1-4H3
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n/an/a 180n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay


J Med Chem 51: 6478-94 (2008)


Article DOI: 10.1021/jm800718k
BindingDB Entry DOI: 10.7270/Q23778KJ
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50147251
PNG
(4-Isopropyl-3-methyl-5-oxo-5H-isoxazole-2-carboxyl...)
Show SMILES CC(C)c1c(C)n(oc1=O)C(=O)N(C)Cc1cccs1
Show InChI InChI=1S/C14H18N2O3S/c1-9(2)12-10(3)16(19-13(12)17)14(18)15(4)8-11-6-5-7-20-11/h5-7,9H,8H2,1-4H3
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n/an/a 2n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay


J Med Chem 51: 6478-94 (2008)


Article DOI: 10.1021/jm800718k
BindingDB Entry DOI: 10.7270/Q23778KJ
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50147241
PNG
(4-Isopropyl-3-methyl-5-oxo-5H-isoxazole-2-carboxyl...)
Show SMILES CC(C)c1c(C)n(oc1=O)C(=O)N(C)Cc1ccco1
Show InChI InChI=1S/C14H18N2O4/c1-9(2)12-10(3)16(20-13(12)17)14(18)15(4)8-11-6-5-7-19-11/h5-7,9H,8H2,1-4H3
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n/an/a 4n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay


J Med Chem 51: 6478-94 (2008)


Article DOI: 10.1021/jm800718k
BindingDB Entry DOI: 10.7270/Q23778KJ
More data for this
Ligand-Target Pair
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