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Found 174 hits Enz. Inhib. hit(s) with Target = 'Insulin-like growth factor 1 receptor (964-1370)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184511
PNG
(US9150578, I-140)
Show SMILES COCCNC(=O)Cn1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(C)c2)n1
Show InChI InChI=1S/C28H30N10O2/c1-36-16-21(15-31-36)18-4-6-19(7-5-18)27-25-22(34-37(27)2)9-8-20-14-30-28(33-26(20)25)32-23-10-12-38(35-23)17-24(39)29-11-13-40-3/h4-7,10,12,14-16H,8-9,11,13,17H2,1-3H3,(H,29,39)(H,30,32,33,35)
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n/an/a 0.560n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184512
PNG
(US9150578, I-141)
Show SMILES COCCN(C)C(=O)Cn1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(C)c2)n1
Show InChI InChI=1S/C29H32N10O2/c1-36(13-14-41-4)25(40)18-39-12-11-24(35-39)32-29-30-15-21-9-10-23-26(27(21)33-29)28(38(3)34-23)20-7-5-19(6-8-20)22-16-31-37(2)17-22/h5-8,11-12,15-17H,9-10,13-14,18H2,1-4H3,(H,30,32,33,35)
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n/an/a 0.510n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184513
PNG
(US9150578, I-142)
Show SMILES CN(C)CCCNC(=O)Cn1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(C)c2)n1
Show InChI InChI=1S/C30H35N11O/c1-38(2)14-5-13-31-26(42)19-41-15-12-25(37-41)34-30-32-16-22-10-11-24-27(28(22)35-30)29(40(4)36-24)21-8-6-20(7-9-21)23-17-33-39(3)18-23/h6-9,12,15-18H,5,10-11,13-14,19H2,1-4H3,(H,31,42)(H,32,34,35,37)
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n/an/a 0.300n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184514
PNG
(US9150578, I-143)
Show SMILES CN(C)[C@H]1CCN(C1)C(=O)Cn1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(C)c2)n1
Show InChI InChI=1S/C31H35N11O/c1-38(2)24-11-13-41(18-24)27(43)19-42-14-12-26(37-42)34-31-32-15-22-9-10-25-28(29(22)35-31)30(40(4)36-25)21-7-5-20(6-8-21)23-16-33-39(3)17-23/h5-8,12,14-17,24H,9-11,13,18-19H2,1-4H3,(H,32,34,35,37)/t24-/m0/s1
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n/an/a 0.240n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184515
PNG
(US9150578, I-144)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1c-2c(CCc3cnc(Nc4ccn(CC(=O)N5CCOCC5)n4)nc-23)nn1C
Show InChI InChI=1S/C29H30N10O2/c1-36-17-22(16-31-36)19-3-5-20(6-4-19)28-26-23(34-37(28)2)8-7-21-15-30-29(33-27(21)26)32-24-9-10-39(35-24)18-25(40)38-11-13-41-14-12-38/h3-6,9-10,15-17H,7-8,11-14,18H2,1-2H3,(H,30,32,33,35)
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n/an/a 0.390n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184516
PNG
(US9150578, I-145)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(Cc4cccc(c4)-c4cnn(C)c4)c3-c2n1)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C35H39N9O2/c1-42-14-12-27(13-15-42)38-34(45)24-8-10-28(31(18-24)46-4)39-35-36-19-25-9-11-29-32(33(25)40-35)30(44(3)41-29)17-22-6-5-7-23(16-22)26-20-37-43(2)21-26/h5-8,10,16,18-21,27H,9,11-15,17H2,1-4H3,(H,38,45)(H,36,39,40)
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n/an/a 0.200n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184517
PNG
(US9150578, I-146)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(Cc4cccc(c4)-c4cnn(C)c4)c3-c2n1)C(=O)NCCN(C)C
Show InChI InChI=1S/C33H37N9O2/c1-40(2)14-13-34-32(43)23-9-11-26(29(17-23)44-5)37-33-35-18-24-10-12-27-30(31(24)38-33)28(42(4)39-27)16-21-7-6-8-22(15-21)25-19-36-41(3)20-25/h6-9,11,15,17-20H,10,12-14,16H2,1-5H3,(H,34,43)(H,35,37,38)
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n/an/a 0.170n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184518
PNG
(US9150578, I-147)
Show SMILES COCCN1CCC(CC1)NC(=O)c1ccc(Nc2ncc3CCc4nn(C)c(Cc5cccc(c5)-c5cnn(C)c5)c4-c3n2)c(OC)c1
Show InChI InChI=1S/C37H43N9O3/c1-44-23-28(22-39-44)25-7-5-6-24(18-25)19-32-34-31(43-45(32)2)11-9-27-21-38-37(42-35(27)34)41-30-10-8-26(20-33(30)49-4)36(47)40-29-12-14-46(15-13-29)16-17-48-3/h5-8,10,18,20-23,29H,9,11-17,19H2,1-4H3,(H,40,47)(H,38,41,42)
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n/an/a 0.160n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184519
PNG
(US9150578, I-148)
Show SMILES CNC(=O)c1ccc(Nc2ncc3CCc4nn(C)c(Cc5cccc(c5)-c5cnn(C)c5)c4-c3n2)c(OC)c1
Show InChI InChI=1S/C30H30N8O2/c1-31-29(39)20-8-10-23(26(14-20)40-4)34-30-32-15-21-9-11-24-27(28(21)35-30)25(38(3)36-24)13-18-6-5-7-19(12-18)22-16-33-37(2)17-22/h5-8,10,12,14-17H,9,11,13H2,1-4H3,(H,31,39)(H,32,34,35)
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n/an/a 0.150n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184520
PNG
(US9150578, I-149)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(Cc4cccc(c4)-c4cnn(C)c4)c3-c2n1)C(=O)NCCCN(C)C
Show InChI InChI=1S/C34H39N9O2/c1-41(2)15-7-14-35-33(44)24-10-12-27(30(18-24)45-5)38-34-36-19-25-11-13-28-31(32(25)39-34)29(43(4)40-28)17-22-8-6-9-23(16-22)26-20-37-42(3)21-26/h6,8-10,12,16,18-21H,7,11,13-15,17H2,1-5H3,(H,35,44)(H,36,38,39)
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n/an/a 0.0800n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184521
PNG
(US9150578, I-150)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(Cc4cccc(c4)-c4cnn(C)c4)c3-c2n1)C(=O)NCCN1CCCC1
Show InChI InChI=1S/C35H39N9O2/c1-42-22-27(21-38-42)24-8-6-7-23(17-24)18-30-32-29(41-43(30)2)12-10-26-20-37-35(40-33(26)32)39-28-11-9-25(19-31(28)46-3)34(45)36-13-16-44-14-4-5-15-44/h6-9,11,17,19-22H,4-5,10,12-16,18H2,1-3H3,(H,36,45)(H,37,39,40)
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n/an/a 0.140n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184522
PNG
(US9150578, I-151)
Show SMILES COCCNC(=O)c1ccc(Nc2ncc3CCc4nn(C)c(Cc5cccc(c5)-c5cnn(C)c5)c4-c3n2)c(OC)c1
Show InChI InChI=1S/C32H34N8O3/c1-39-19-24(18-35-39)21-7-5-6-20(14-21)15-27-29-26(38-40(27)2)11-9-23-17-34-32(37-30(23)29)36-25-10-8-22(16-28(25)43-4)31(41)33-12-13-42-3/h5-8,10,14,16-19H,9,11-13,15H2,1-4H3,(H,33,41)(H,34,36,37)
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n/an/a 0.370n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184523
PNG
(US9150578, I-152)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)C(=O)NCCN1CCN(C)CC1
Show InChI InChI=1S/C35H40N10O2/c1-42-15-17-45(18-16-42)14-13-36-34(46)25-9-11-28(30(19-25)47-4)39-35-37-20-26-10-12-29-31(32(26)40-35)33(44(3)41-29)24-7-5-23(6-8-24)27-21-38-43(2)22-27/h5-9,11,19-22H,10,12-18H2,1-4H3,(H,36,46)(H,37,39,40)
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n/an/a 0.210n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184524
PNG
(US9150578, I-153)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)C(=O)NCCN1CCOCC1
Show InChI InChI=1S/C34H37N9O3/c1-41-21-26(20-37-41)22-4-6-23(7-5-22)32-30-28(40-42(32)2)11-9-25-19-36-34(39-31(25)30)38-27-10-8-24(18-29(27)45-3)33(44)35-12-13-43-14-16-46-17-15-43/h4-8,10,18-21H,9,11-17H2,1-3H3,(H,35,44)(H,36,38,39)
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n/an/a 0.380n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184525
PNG
(US9150578, I-154)
Show SMILES COCCCNC(=O)c1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(C)c2)c(OC)c1
Show InChI InChI=1S/C32H34N8O3/c1-39-19-24(18-35-39)20-6-8-21(9-7-20)30-28-26(38-40(30)2)13-11-23-17-34-32(37-29(23)28)36-25-12-10-22(16-27(25)43-4)31(41)33-14-5-15-42-3/h6-10,12,16-19H,5,11,13-15H2,1-4H3,(H,33,41)(H,34,36,37)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184526
PNG
(US9150578, I-155)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)C(=O)N(C)CCN(C)C
Show InChI InChI=1S/C33H37N9O2/c1-39(2)15-16-40(3)32(43)23-11-13-26(28(17-23)44-6)36-33-34-18-24-12-14-27-29(30(24)37-33)31(42(5)38-27)22-9-7-21(8-10-22)25-19-35-41(4)20-25/h7-11,13,17-20H,12,14-16H2,1-6H3,(H,34,36,37)
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n/an/a 0.150n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184527
PNG
(US9150578, I-156)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)C(=O)N1CCOCC1
Show InChI InChI=1S/C32H32N8O3/c1-38-19-24(18-34-38)20-4-6-21(7-5-20)30-28-26(37-39(30)2)11-9-23-17-33-32(36-29(23)28)35-25-10-8-22(16-27(25)42-3)31(41)40-12-14-43-15-13-40/h4-8,10,16-19H,9,11-15H2,1-3H3,(H,33,35,36)
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n/an/a 0.220n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184528
PNG
(US9150578, I-157)
Show SMILES CCNC(=O)c1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(C)c2)c(OC)c1
Show InChI InChI=1S/C30H30N8O2/c1-5-31-29(39)20-10-12-23(25(14-20)40-4)34-30-32-15-21-11-13-24-26(27(21)35-30)28(38(3)36-24)19-8-6-18(7-9-19)22-16-33-37(2)17-22/h6-10,12,14-17H,5,11,13H2,1-4H3,(H,31,39)(H,32,34,35)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184529
PNG
(US9150578, I-158)
Show SMILES CCCNC(=O)c1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(C)c2)c(OC)c1
Show InChI InChI=1S/C31H32N8O2/c1-5-14-32-30(40)21-10-12-24(26(15-21)41-4)35-31-33-16-22-11-13-25-27(28(22)36-31)29(39(3)37-25)20-8-6-19(7-9-20)23-17-34-38(2)18-23/h6-10,12,15-18H,5,11,13-14H2,1-4H3,(H,32,40)(H,33,35,36)
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n/an/a 0.660n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184530
PNG
(US9150578, I-159)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)C(=O)NCC1CCN(C)CC1
Show InChI InChI=1S/C35H39N9O2/c1-42-15-13-22(14-16-42)18-36-34(45)25-9-11-28(30(17-25)46-4)39-35-37-19-26-10-12-29-31(32(26)40-35)33(44(3)41-29)24-7-5-23(6-8-24)27-20-38-43(2)21-27/h5-9,11,17,19-22H,10,12-16,18H2,1-4H3,(H,36,45)(H,37,39,40)
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n/an/a 0.160n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184531
PNG
(US9150578, I-160)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)C(=O)NC1CCOCC1
Show InChI InChI=1S/C33H34N8O3/c1-40-19-24(18-35-40)20-4-6-21(7-5-20)31-29-27(39-41(31)2)11-9-23-17-34-33(38-30(23)29)37-26-10-8-22(16-28(26)43-3)32(42)36-25-12-14-44-15-13-25/h4-8,10,16-19,25H,9,11-15H2,1-3H3,(H,36,42)(H,34,37,38)
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n/an/a 0.610n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184532
PNG
(US9150578, I-161)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)C(=O)N(C)C1CCN(C)CC1
Show InChI InChI=1S/C35H39N9O2/c1-41-16-14-27(15-17-41)43(3)34(45)24-10-12-28(30(18-24)46-5)38-35-36-19-25-11-13-29-31(32(25)39-35)33(44(4)40-29)23-8-6-22(7-9-23)26-20-37-42(2)21-26/h6-10,12,18-21,27H,11,13-17H2,1-5H3,(H,36,38,39)
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n/an/a 0.140n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184533
PNG
(US9150578, I-162)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)C(=O)NC[C@@H]1CCCO1
Show InChI InChI=1S/C33H34N8O3/c1-40-19-24(17-36-40)20-6-8-21(9-7-20)31-29-27(39-41(31)2)13-11-23-16-35-33(38-30(23)29)37-26-12-10-22(15-28(26)43-3)32(42)34-18-25-5-4-14-44-25/h6-10,12,15-17,19,25H,4-5,11,13-14,18H2,1-3H3,(H,34,42)(H,35,37,38)/t25-/m0/s1
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n/an/a 0.390n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184534
PNG
(US9150578, I-163)
Show SMILES CO[C@@H]1CN(C)CC[C@H]1NC(=O)c1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(C)c2)c(OC)c1
Show InChI InChI=1S/C35H39N9O3/c1-42-15-14-27(30(20-42)47-5)38-34(45)23-10-12-26(29(16-23)46-4)39-35-36-17-24-11-13-28-31(32(24)40-35)33(44(3)41-28)22-8-6-21(7-9-22)25-18-37-43(2)19-25/h6-10,12,16-19,27,30H,11,13-15,20H2,1-5H3,(H,38,45)(H,36,39,40)/t27-,30-/m1/s1
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n/an/a 0.230n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184535
PNG
(US9150578, I-164)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)C(=O)NC1CN(C)C1
Show InChI InChI=1S/C32H33N9O2/c1-39-17-24(18-39)35-31(42)21-9-11-25(27(13-21)43-4)36-32-33-14-22-10-12-26-28(29(22)37-32)30(41(3)38-26)20-7-5-19(6-8-20)23-15-34-40(2)16-23/h5-9,11,13-16,24H,10,12,17-18H2,1-4H3,(H,35,42)(H,33,36,37)
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n/an/a 0.190n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184536
PNG
(US9150578, I-165)
Show SMILES COCCN(C)C(=O)c1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(C)c2)c(OC)c1
Show InChI InChI=1S/C32H34N8O3/c1-38(14-15-42-4)31(41)22-10-12-25(27(16-22)43-5)35-32-33-17-23-11-13-26-28(29(23)36-32)30(40(3)37-26)21-8-6-20(7-9-21)24-18-34-39(2)19-24/h6-10,12,16-19H,11,13-15H2,1-5H3,(H,33,35,36)
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n/an/a 0.220n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184542
PNG
(US9150578, I-169 | US9150578, I-173)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)N1CCN(C)CC1
Show InChI InChI=1S/C32H35N9O/c1-38-13-15-41(16-14-38)25-10-12-26(28(17-25)42-4)35-32-33-18-23-9-11-27-29(30(23)36-32)31(40(3)37-27)22-7-5-21(6-8-22)24-19-34-39(2)20-24/h5-8,10,12,17-20H,9,11,13-16H2,1-4H3,(H,33,35,36)
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n/an/a 0.200n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184543
PNG
(US9150578, I-170)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(C)c2)c(OC)c1
Show InChI InChI=1S/C33H37N9O/c1-5-41-14-16-42(17-15-41)26-11-13-27(29(18-26)43-4)36-33-34-19-24-10-12-28-30(31(24)37-33)32(40(3)38-28)23-8-6-22(7-9-23)25-20-35-39(2)21-25/h6-9,11,13,18-21H,5,10,12,14-17H2,1-4H3,(H,34,36,37)
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n/an/a 0.0900n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184544
PNG
(US9150578, I-171)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)N1CCN(CC1)C1CCOCC1
Show InChI InChI=1S/C36H41N9O2/c1-42-23-27(22-38-42)24-4-6-25(7-5-24)35-33-31(41-43(35)2)10-8-26-21-37-36(40-34(26)33)39-30-11-9-29(20-32(30)46-3)45-16-14-44(15-17-45)28-12-18-47-19-13-28/h4-7,9,11,20-23,28H,8,10,12-19H2,1-3H3,(H,37,39,40)
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n/an/a 0.0800n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184545
PNG
(US9150578, I-172)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)N1CCN(CC1)C(C)C
Show InChI InChI=1S/C34H39N9O/c1-22(2)42-14-16-43(17-15-42)27-11-13-28(30(18-27)44-5)37-34-35-19-25-10-12-29-31(32(25)38-34)33(41(4)39-29)24-8-6-23(7-9-24)26-20-36-40(3)21-26/h6-9,11,13,18-22H,10,12,14-17H2,1-5H3,(H,35,37,38)
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n/an/a 0.0500n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184542
PNG
(US9150578, I-169 | US9150578, I-173)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)N1CCN(C)CC1
Show InChI InChI=1S/C32H35N9O/c1-38-13-15-41(16-14-38)25-10-12-26(28(17-25)42-4)35-32-33-18-23-9-11-27-29(30(23)36-32)31(40(3)37-27)22-7-5-21(6-8-22)24-19-34-39(2)20-24/h5-8,10,12,17-20H,9,11,13-16H2,1-4H3,(H,33,35,36)
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n/an/a 0.100n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184548
PNG
(US9150578, I-174)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)N1CCN(CCO)CC1
Show InChI InChI=1S/C33H37N9O2/c1-39-21-25(20-35-39)22-4-6-23(7-5-22)32-30-28(38-40(32)2)10-8-24-19-34-33(37-31(24)30)36-27-11-9-26(18-29(27)44-3)42-14-12-41(13-15-42)16-17-43/h4-7,9,11,18-21,43H,8,10,12-17H2,1-3H3,(H,34,36,37)
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n/an/a 0.0800n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184549
PNG
(US9150578, I-175)
Show SMILES COCCN1CCC(CC1)n1cc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(C)c2)cn1
Show InChI InChI=1S/C31H36N10O/c1-38-19-24(17-33-38)21-4-6-22(7-5-21)30-28-27(37-39(30)2)9-8-23-16-32-31(36-29(23)28)35-25-18-34-41(20-25)26-10-12-40(13-11-26)14-15-42-3/h4-7,16-20,26H,8-15H2,1-3H3,(H,32,35,36)
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n/an/a 0.160n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184551
PNG
(US9150578, I-176)
Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)N1CCN(CC1)S(=O)(=O)N(C)C
Show InChI InChI=1S/C33H38N10O3S/c1-39(2)47(44,45)43-16-14-42(15-17-43)26-11-13-27(29(18-26)46-5)36-33-34-19-24-10-12-28-30(31(24)37-33)32(41(4)38-28)23-8-6-22(7-9-23)25-20-35-40(3)21-25/h6-9,11,13,18-21H,10,12,14-17H2,1-5H3,(H,34,36,37)
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n/an/a 2n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184552
PNG
(US9150578, I-177)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1c-2c(CCc3cnc(Nc4cnn(c4)C4CCN(CC4)S(C)(=O)=O)nc-23)nn1C
Show InChI InChI=1S/C29H32N10O2S/c1-36-17-22(15-31-36)19-4-6-20(7-5-19)28-26-25(35-37(28)2)9-8-21-14-30-29(34-27(21)26)33-23-16-32-39(18-23)24-10-12-38(13-11-24)42(3,40)41/h4-7,14-18,24H,8-13H2,1-3H3,(H,30,33,34)
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n/an/a 0.230n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184553
PNG
(US9150578, I-178)
Show SMILES CN(C)S(=O)(=O)N1CCC(CC1)n1cc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(C)c2)cn1
Show InChI InChI=1S/C30H35N11O2S/c1-37(2)44(42,43)40-13-11-25(12-14-40)41-19-24(17-33-41)34-30-31-15-22-9-10-26-27(28(22)35-30)29(39(4)36-26)21-7-5-20(6-8-21)23-16-32-38(3)18-23/h5-8,15-19,25H,9-14H2,1-4H3,(H,31,34,35)
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n/an/a 0.340n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184394
PNG
(US9150578, I-179)
Show SMILES Cn1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(nc2)-c2cnn(C)c2)n1
Show InChI InChI=1S/C23H22N10/c1-31-9-8-19(30-31)27-23-25-10-14-4-7-18-20(21(14)28-23)22(33(3)29-18)15-5-6-17(24-11-15)16-12-26-32(2)13-16/h5-6,8-13H,4,7H2,1-3H3,(H,25,27,28,30)
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n/an/a 4n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184395
PNG
(US9150578, I-180)
Show SMILES CC(=O)N1CCC(CC1)n1cc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(nc2)-c2cnn(C)c2)cn1
Show InChI InChI=1S/C29H31N11O/c1-18(41)39-10-8-23(9-11-39)40-17-22(15-33-40)34-29-31-12-19-4-7-25-26(27(19)35-29)28(38(3)36-25)20-5-6-24(30-13-20)21-14-32-37(2)16-21/h5-6,12-17,23H,4,7-11H2,1-3H3,(H,31,34,35)
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n/an/a 2n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184396
PNG
(US9150578, I-181)
Show SMILES CN(C)CCn1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(nc2)-c2cnn(C)c2)n1
Show InChI InChI=1S/C26H29N11/c1-34(2)11-12-37-10-9-22(33-37)30-26-28-13-17-5-8-21-23(24(17)31-26)25(36(4)32-21)18-6-7-20(27-14-18)19-15-29-35(3)16-19/h6-7,9-10,13-16H,5,8,11-12H2,1-4H3,(H,28,30,31,33)
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n/an/a 2n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184397
PNG
(US9150578, I-182 | US9150578, I-183)
Show SMILES COCCn1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(nc2)-c2cnn(C)c2)n1
Show InChI InChI=1S/C25H26N10O/c1-33-15-18(14-28-33)19-6-5-17(13-26-19)24-22-20(31-34(24)2)7-4-16-12-27-25(30-23(16)22)29-21-8-9-35(32-21)10-11-36-3/h5-6,8-9,12-15H,4,7,10-11H2,1-3H3,(H,27,29,30,32)
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n/an/a 2n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184397
PNG
(US9150578, I-182 | US9150578, I-183)
Show SMILES COCCn1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(nc2)-c2cnn(C)c2)n1
Show InChI InChI=1S/C25H26N10O/c1-33-15-18(14-28-33)19-6-5-17(13-26-19)24-22-20(31-34(24)2)7-4-16-12-27-25(30-23(16)22)29-21-8-9-35(32-21)10-11-36-3/h5-6,8-9,12-15H,4,7,10-11H2,1-3H3,(H,27,29,30,32)
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n/an/a 2n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184399
PNG
(US9150578, I-184)
Show SMILES CN(C)CCn1cc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(nc2)-c2cnn(C)c2)cn1
Show InChI InChI=1S/C26H29N11/c1-34(2)9-10-37-16-20(14-30-37)31-26-28-11-17-5-8-22-23(24(17)32-26)25(36(4)33-22)18-6-7-21(27-12-18)19-13-29-35(3)15-19/h6-7,11-16H,5,8-10H2,1-4H3,(H,28,31,32)
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n/an/a 5n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184400
PNG
(US9150578, I-185)
Show SMILES Cn1cc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(nc2)-c2cnn(C)c2)cn1
Show InChI InChI=1S/C23H22N10/c1-31-12-16(10-26-31)18-6-5-15(9-24-18)22-20-19(30-33(22)3)7-4-14-8-25-23(29-21(14)20)28-17-11-27-32(2)13-17/h5-6,8-13H,4,7H2,1-3H3,(H,25,28,29)
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n/an/a 2n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184401
PNG
(US9150578, I-186)
Show SMILES COCCn1cc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(nc2)-c2cnn(C)c2)cn1
Show InChI InChI=1S/C25H26N10O/c1-33-14-18(12-28-33)20-6-5-17(11-26-20)24-22-21(32-34(24)2)7-4-16-10-27-25(31-23(16)22)30-19-13-29-35(15-19)8-9-36-3/h5-6,10-15H,4,7-9H2,1-3H3,(H,27,30,31)
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n/an/a 2n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184402
PNG
(US9150578, I-187)
Show SMILES CCn1cc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(nc2)-c2cnn(C)c2)cn1
Show InChI InChI=1S/C24H24N10/c1-4-34-14-18(12-28-34)29-24-26-9-15-5-8-20-21(22(15)30-24)23(33(3)31-20)16-6-7-19(25-10-16)17-11-27-32(2)13-17/h6-7,9-14H,4-5,8H2,1-3H3,(H,26,29,30)
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n/an/a 3n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184403
PNG
(US9150578, I-188)
Show SMILES Cn1cc(cn1)-c1ccc(cn1)-c1c-2c(CCc3cnc(Nc4cnn(CCN5CCOCC5)c4)nc-23)nn1C
Show InChI InChI=1S/C28H31N11O/c1-36-17-21(15-31-36)23-5-4-20(14-29-23)27-25-24(35-37(27)2)6-3-19-13-30-28(34-26(19)25)33-22-16-32-39(18-22)8-7-38-9-11-40-12-10-38/h4-5,13-18H,3,6-12H2,1-2H3,(H,30,33,34)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184404
PNG
(US9150578, I-189)
Show SMILES CC(C)n1cc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(nc2)-c2cnn(C)c2)cn1
Show InChI InChI=1S/C25H26N10/c1-15(2)35-14-19(12-29-35)30-25-27-9-16-5-8-21-22(23(16)31-25)24(34(4)32-21)17-6-7-20(26-10-17)18-11-28-33(3)13-18/h6-7,9-15H,5,8H2,1-4H3,(H,27,30,31)
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n/an/a 0.310n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184488
PNG
(US9150578, I-190)
Show SMILES COCCn1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(CCN3CCO[C@@H](C)C3)c2)n1
Show InChI InChI=1S/C32H38N10O2/c1-22-20-40(14-17-44-22)12-13-42-21-26(19-34-42)23-4-6-24(7-5-23)31-29-27(37-39(31)2)9-8-25-18-33-32(36-30(25)29)35-28-10-11-41(38-28)15-16-43-3/h4-7,10-11,18-19,21-22H,8-9,12-17,20H2,1-3H3,(H,33,35,36,38)/t22-/m0/s1
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n/an/a 0.350n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184489
PNG
(US9150578, I-191)
Show SMILES COCCn1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(CCN3CCC(CC3)C#N)c2)n1
Show InChI InChI=1S/C33H37N11O/c1-41-32(25-5-3-24(4-6-25)27-21-36-44(22-27)16-15-42-12-9-23(19-34)10-13-42)30-28(39-41)8-7-26-20-35-33(38-31(26)30)37-29-11-14-43(40-29)17-18-45-2/h3-6,11,14,20-23H,7-10,12-13,15-18H2,1-2H3,(H,35,37,38,40)
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n/an/a 0.260n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184355
PNG
(US9150578, I-003)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1c-2c(CCc3cnc(Nc4ccn(CCO)n4)nc-23)nn1C
Show InChI InChI=1S/C25H25N9O/c1-32-15-19(14-27-32)16-3-5-17(6-4-16)24-22-20(30-33(24)2)8-7-18-13-26-25(29-23(18)22)28-21-9-10-34(31-21)11-12-35/h3-6,9-10,13-15,35H,7-8,11-12H2,1-2H3,(H,26,28,29,31)
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n/an/a 0.230n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
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