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Compile Data Set for Download or QSAR

Found 176 hits Enz. Inhib. hit(s) with Target = 'Intermediate conductance calcium-activated potassium channel protein 4'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205004
PNG
(US9556132, 2 | process for preparing 2-{2-[1-(2-fl...)
Show SMILES Fc1ccccc1-n1nnnc1-c1ccccc1I
Show InChI InChI=1S/C13H8FIN4/c14-10-6-2-4-8-12(10)19-13(16-17-18-19)9-5-1-3-7-11(9)15/h1-8H
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n/an/a 5.90E+3n/an/an/an/a7.3n/a



Saniona A/S

US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205081
PNG
(US9556132, 65 | process for preparing 1-phenyl-5-(...)
Show SMILES c1ccc(cc1)\N=C(/c1ccccc1-c1ccccc1)n1nnc2ccccc12
Show InChI InChI=1S/C25H18N4/c1-3-11-19(12-4-1)21-15-7-8-16-22(21)25(26-20-13-5-2-6-14-20)29-24-18-10-9-17-23(24)27-28-29/h1-18H/b26-25+
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n/an/a 890n/an/an/an/a7.3n/a



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US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205019
PNG
(US9556132, 4 | process for preparing 1-(2-fluoroph...)
Show SMILES COCCOc1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1F
Show InChI InChI=1S/C22H19FN4O2/c1-28-14-15-29-21-13-7-4-9-17(21)16-8-2-3-10-18(16)22-24-25-26-27(22)20-12-6-5-11-19(20)23/h2-13H,14-15H2,1H3
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n/an/a 30n/an/an/an/a7.3n/a



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US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205022
PNG
(US9556132, 40 | US9556132, 5)
Show SMILES FC(F)Oc1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1F
Show InChI InChI=1S/C20H13F3N4O/c21-16-10-4-5-11-17(16)27-19(24-25-26-27)15-9-2-1-7-13(15)14-8-3-6-12-18(14)28-20(22)23/h1-12,20H
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n/an/a 290n/an/an/an/a7.3n/a



Saniona A/S

US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205028
PNG
(US9556132, 6 | process for preparing 5-{2-[2-(cycl...)
Show SMILES Fc1ccccc1-n1nnnc1-c1ccccc1-c1ccccc1OCC1CC1
Show InChI InChI=1S/C23H19FN4O/c24-20-10-4-5-11-21(20)28-23(25-26-27-28)19-9-2-1-7-17(19)18-8-3-6-12-22(18)29-15-16-13-14-16/h1-12,16H,13-15H2
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n/an/a 710n/an/an/an/a7.3n/a



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US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205030
PNG
(US9556132, 7 | process for preparing 2-(2-{2-[1-(2...)
Show SMILES Fc1ccccc1-n1nnnc1-c1ccccc1-c1ccccc1OCC#N
Show InChI InChI=1S/C21H14FN5O/c22-18-10-4-5-11-19(18)27-21(24-25-26-27)17-9-2-1-7-15(17)16-8-3-6-12-20(16)28-14-13-23/h1-12H,14H2
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n/an/a 16n/an/an/an/a7.3n/a



Saniona A/S

US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205044
PNG
(US9556132, 8 | process for preparing methyl 2-(2-{...)
Show SMILES COC(=O)COc1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1F
Show InChI InChI=1S/C22H17FN4O3/c1-29-21(28)14-30-20-13-7-4-9-16(20)15-8-2-3-10-17(15)22-24-25-26-27(22)19-12-6-5-11-18(19)23/h2-13H,14H2,1H3
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n/an/a 590n/an/an/an/a7.3n/a



Saniona A/S

US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205045
PNG
(US9556132, 9 | process for preparing 1-(2-fluoroph...)
Show SMILES CC(C)Oc1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1F
Show InChI InChI=1S/C22H19FN4O/c1-15(2)28-21-14-8-5-10-17(21)16-9-3-4-11-18(16)22-24-25-26-27(22)20-13-7-6-12-19(20)23/h3-15H,1-2H3
PDB

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n/an/a 770n/an/an/an/a7.3n/a



Saniona A/S

US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205049
PNG
(US9556132, 12 | process for preparing 5-{2-[2-(flu...)
Show SMILES FCOc1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1F
Show InChI InChI=1S/C20H14F2N4O/c21-13-27-19-12-6-3-8-15(19)14-7-1-2-9-16(14)20-23-24-25-26(20)18-11-5-4-10-17(18)22/h1-12H,13H2
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Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205050
PNG
(US9556132, 13 | process for preparing 1-(2-fluorop...)
Show SMILES COc1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1F
Show InChI InChI=1S/C20H15FN4O/c1-26-19-13-7-4-9-15(19)14-8-2-3-10-16(14)20-22-23-24-25(20)18-12-6-5-11-17(18)21/h2-13H,1H3
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US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205051
PNG
(US9556132, 14 | process for preparing 1-(2-fluorop...)
Show SMILES CSc1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1F
Show InChI InChI=1S/C20H15FN4S/c1-26-19-13-7-4-9-15(19)14-8-2-3-10-16(14)20-22-23-24-25(20)18-12-6-5-11-17(18)21/h2-13H,1H3
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US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205052
PNG
(US9556132, 15 | process for preparing 1-(2-fluorop...)
Show SMILES Fc1ccccc1-n1nnnc1-c1ccccc1-c1ccccc1OC(F)(F)F
Show InChI InChI=1S/C20H12F4N4O/c21-16-10-4-5-11-17(16)28-19(25-26-27-28)15-9-2-1-7-13(15)14-8-3-6-12-18(14)29-20(22,23)24/h1-12H
PDB

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n/an/a 1.70E+3n/an/an/an/a7.3n/a



Saniona A/S

US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205053
PNG
(US9556132, 16 | process for preparing 1-(2-fluorop...)
Show SMILES COCOc1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1F
Show InChI InChI=1S/C21H17FN4O2/c1-27-14-28-20-13-7-4-9-16(20)15-8-2-3-10-17(15)21-23-24-25-26(21)19-12-6-5-11-18(19)22/h2-13H,14H2,1H3
PDB

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US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205054
PNG
(US9556132, 17 | process for preparing 2-(2-{2-[1-(...)
Show SMILES NC(=O)COc1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1F
Show InChI InChI=1S/C21H16FN5O2/c22-17-10-4-5-11-18(17)27-21(24-25-26-27)16-9-2-1-7-14(16)15-8-3-6-12-19(15)29-13-20(23)28/h1-12H,13H2,(H2,23,28)
PDB

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n/an/a 1.00E+3n/an/an/an/a7.3n/a



Saniona A/S

US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205055
PNG
(US9556132, 19 | process for preparing 1-(2-fluorop...)
Show SMILES Cc1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1F
Show InChI InChI=1S/C20H15FN4/c1-14-8-2-3-9-15(14)16-10-4-5-11-17(16)20-22-23-24-25(20)19-13-7-6-12-18(19)21/h2-13H,1H3
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n/an/a 510n/an/an/an/a7.3n/a



Saniona A/S

US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205056
PNG
(US9556132, 20 | process for preparing 5-[2-(2-ethy...)
Show SMILES CCc1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1F
Show InChI InChI=1S/C21H17FN4/c1-2-15-9-3-4-10-16(15)17-11-5-6-12-18(17)21-23-24-25-26(21)20-14-8-7-13-19(20)22/h3-14H,2H2,1H3
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US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205057
PNG
(US9556132, 21 | process for preparing 2-{2-[1-(2-f...)
Show SMILES Fc1ccccc1-n1nnnc1-c1ccccc1-c1ccccc1C=O
Show InChI InChI=1S/C20H13FN4O/c21-18-11-5-6-12-19(18)25-20(22-23-24-25)17-10-4-3-9-16(17)15-8-2-1-7-14(15)13-26/h1-13H
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US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205058
PNG
(US9556132, 22 | process for preparing 1-(2-fluorop...)
Show SMILES Fc1ccccc1-n1nnnc1-c1ccccc1-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C20H12F4N4/c21-17-11-5-6-12-18(17)28-19(25-26-27-28)15-9-2-1-7-13(15)14-8-3-4-10-16(14)20(22,23)24/h1-12H
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US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205059
PNG
(US9556132, 23 | process for preparing 5-[2-(2-brom...)
Show SMILES Fc1ccccc1-n1nnnc1-c1ccccc1-c1ccccc1Br
Show InChI InChI=1S/C19H12BrFN4/c20-16-10-4-3-8-14(16)13-7-1-2-9-15(13)19-22-23-24-25(19)18-12-6-5-11-17(18)21/h1-12H
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Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205060
PNG
(US9556132, 24 | US9556132, 25 | process for prepar...)
Show SMILES Fc1ccccc1-n1nnnc1-c1ccccc1-c1ccccc1Cl
Show InChI InChI=1S/C19H12ClFN4/c20-16-10-4-3-8-14(16)13-7-1-2-9-15(13)19-22-23-24-25(19)18-12-6-5-11-17(18)21/h1-12H
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US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205060
PNG
(US9556132, 24 | US9556132, 25 | process for prepar...)
Show SMILES Fc1ccccc1-n1nnnc1-c1ccccc1-c1ccccc1Cl
Show InChI InChI=1S/C19H12ClFN4/c20-16-10-4-3-8-14(16)13-7-1-2-9-15(13)19-22-23-24-25(19)18-12-6-5-11-17(18)21/h1-12H
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US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205062
PNG
(US9556132, 26 | process for preparing 2-{2-[1-(2-f...)
Show SMILES CN(C)c1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1F
Show InChI InChI=1S/C21H18FN5/c1-26(2)19-13-7-5-10-16(19)15-9-3-4-11-17(15)21-23-24-25-27(21)20-14-8-6-12-18(20)22/h3-14H,1-2H3
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n/an/a 820n/an/an/an/a7.3n/a



Saniona A/S

US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205063
PNG
(US9556132, 27 | process for preparing 2-{2-[1-(2-f...)
Show SMILES Nc1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1F
Show InChI InChI=1S/C19H14FN5/c20-16-10-4-6-12-18(16)25-19(22-23-24-25)15-9-2-1-7-13(15)14-8-3-5-11-17(14)21/h1-12H,21H2
PDB

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US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205064
PNG
(US9556132, 28 | process for preparing (2-{2-[1-(2-...)
Show SMILES OCc1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1F
Show InChI InChI=1S/C20H15FN4O/c21-18-11-5-6-12-19(18)25-20(22-23-24-25)17-10-4-3-9-16(17)15-8-2-1-7-14(15)13-26/h1-12,26H,13H2
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US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205065
PNG
(US9556132, 29 | process for preparing 1-(2-fluorop...)
Show SMILES COCc1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1F
Show InChI InChI=1S/C21H17FN4O/c1-27-14-15-8-2-3-9-16(15)17-10-4-5-11-18(17)21-23-24-25-26(21)20-13-7-6-12-19(20)22/h2-13H,14H2,1H3
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US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205066
PNG
(US9556132, 30 | process for preparing (e)-n-[(2-{2...)
Show SMILES O\N=C/c1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1F
Show InChI InChI=1S/C20H14FN5O/c21-18-11-5-6-12-19(18)26-20(23-24-25-26)17-10-4-3-9-16(17)15-8-2-1-7-14(15)13-22-27/h1-13,27H/b22-13-
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US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205067
PNG
(US9556132, 31 | process for preparing 2-{2-[1-(2-f...)
Show SMILES O\N=C\c1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1F
Show InChI InChI=1S/C20H14FN5O/c21-18-11-5-6-12-19(18)26-20(23-24-25-26)17-10-4-3-9-16(17)15-8-2-1-7-14(15)13-22-27/h1-13,27H/b22-13+
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Saniona A/S

US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205068
PNG
(US9556132, 32 | process for preparing 5-{2-[2-(dif...)
Show SMILES FC(F)c1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1F
Show InChI InChI=1S/C20H13F3N4/c21-17-11-5-6-12-18(17)27-20(24-25-26-27)16-10-4-2-8-14(16)13-7-1-3-9-15(13)19(22)23/h1-12,19H
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Saniona A/S

US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205069
PNG
(US9556132, 33 | process for preparing 5-{2-[2-(flu...)
Show SMILES FCc1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1F
Show InChI InChI=1S/C20H14F2N4/c21-13-14-7-1-2-8-15(14)16-9-3-4-10-17(16)20-23-24-25-26(20)19-12-6-5-11-18(19)22/h1-12H,13H2
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Saniona A/S

US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205022
PNG
(US9556132, 40 | US9556132, 5)
Show SMILES FC(F)Oc1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1F
Show InChI InChI=1S/C20H13F3N4O/c21-16-10-4-5-11-17(16)27-19(24-25-26-27)15-9-2-1-7-13(15)14-8-3-6-12-18(14)28-20(22)23/h1-12,20H
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n/an/a 800n/an/an/an/a7.3n/a



Saniona A/S

US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205071
PNG
(US9556132, 42 | process for preparing 2-{2-[1-(2-f...)
Show SMILES COCCNc1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1F
Show InChI InChI=1S/C22H20FN5O/c1-29-15-14-24-20-12-6-4-9-17(20)16-8-2-3-10-18(16)22-25-26-27-28(22)21-13-7-5-11-19(21)23/h2-13,24H,14-15H2,1H3
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n/an/a 680n/an/an/an/a7.3n/a



Saniona A/S

US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205072
PNG
(US9556132, 48 | process for preparing 1-(2-chlorop...)
Show SMILES Fc1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1Cl
Show InChI InChI=1S/C19H12ClFN4/c20-16-10-4-6-12-18(16)25-19(22-23-24-25)15-9-2-1-7-13(15)14-8-3-5-11-17(14)21/h1-12H
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n/an/a 1.00E+3n/an/an/an/a7.3n/a



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US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205073
PNG
(US9556132, 49 | process for preparing 1-(2-chlorop...)
Show SMILES COc1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1Cl
Show InChI InChI=1S/C20H15ClN4O/c1-26-19-13-7-4-9-15(19)14-8-2-3-10-16(14)20-22-23-24-25(20)18-12-6-5-11-17(18)21/h2-13H,1H3
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Saniona A/S

US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205074
PNG
(US9556132, 51 | process for preparing 1-(2-methoxy...)
Show SMILES COc1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1OC
Show InChI InChI=1S/C21H18N4O2/c1-26-19-13-7-5-10-16(19)15-9-3-4-11-17(15)21-22-23-24-25(21)18-12-6-8-14-20(18)27-2/h3-14H,1-2H3
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n/an/a 1.20E+3n/an/an/an/a7.3n/a



Saniona A/S

US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205075
PNG
(US9556132, 53 | process for preparing 2-{5-[2-(2-m...)
Show SMILES COc1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1O
Show InChI InChI=1S/C20H16N4O2/c1-26-19-13-7-4-9-15(19)14-8-2-3-10-16(14)20-21-22-23-24(20)17-11-5-6-12-18(17)25/h2-13,25H,1H3
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Saniona A/S

US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205076
PNG
(US9556132, 54 | process for preparing 5-[2-(2-fluo...)
Show SMILES COc1ccccc1-n1nnnc1-c1ccccc1-c1ccccc1F
Show InChI InChI=1S/C20H15FN4O/c1-26-19-13-7-6-12-18(19)25-20(22-23-24-25)16-10-3-2-8-14(16)15-9-4-5-11-17(15)21/h2-13H,1H3
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Saniona A/S

US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205077
PNG
(US9556132, 56 | process for preparing 2-{5-[2-(2-m...)
Show SMILES COc1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1C#N
Show InChI InChI=1S/C21H15N5O/c1-27-20-13-7-5-10-17(20)16-9-3-4-11-18(16)21-23-24-25-26(21)19-12-6-2-8-15(19)14-22/h2-13H,1H3
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Saniona A/S

US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205078
PNG
(US9556132, 58 | process for preparing 1-[2-(difluo...)
Show SMILES FC(F)Oc1ccccc1-n1nnnc1-c1ccccc1-c1ccccc1F
Show InChI InChI=1S/C20H13F3N4O/c21-16-10-4-3-8-14(16)13-7-1-2-9-15(13)19-24-25-26-27(19)17-11-5-6-12-18(17)28-20(22)23/h1-12,20H
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n/an/a 1.10E+3n/an/an/an/a7.3n/a



Saniona A/S

US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205079
PNG
(US9556132, 59 | process for preparing 1-[2-(difluo...)
Show SMILES COc1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1OC(F)F
Show InChI InChI=1S/C21H16F2N4O2/c1-28-18-12-6-4-9-15(18)14-8-2-3-10-16(14)20-24-25-26-27(20)17-11-5-7-13-19(17)29-21(22)23/h2-13,21H,1H3
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n/an/a 69n/an/an/an/a7.3n/a



Saniona A/S

US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205080
PNG
(US9556132, 62 | process for preparing 2-(5-{2-[2-(...)
Show SMILES FC(F)Oc1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1C#N
Show InChI InChI=1S/C21H13F2N5O/c22-21(23)29-19-12-6-4-9-16(19)15-8-2-3-10-17(15)20-25-26-27-28(20)18-11-5-1-7-14(18)13-24/h1-12,21H
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n/an/a 210n/an/an/an/a7.3n/a



Saniona A/S

US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM205016
PNG
(US9556132, 3 | process for preparing 5-[2-(2-ethox...)
Show SMILES CCOc1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1F
Show InChI InChI=1S/C21H17FN4O/c1-2-27-20-14-8-5-10-16(20)15-9-3-4-11-17(15)21-23-24-25-26(21)19-13-7-6-12-18(19)22/h3-14H,2H2,1H3
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Saniona A/S

US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50371391
PNG
(SENICAPOC)
Show SMILES NC(=O)C(c1ccccc1)(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C20H15F2NO/c21-17-10-6-15(7-11-17)20(19(23)24,14-4-2-1-3-5-14)16-8-12-18(22)13-9-16/h1-13H,(H2,23,24)
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n/an/a 6n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of Kca 3.1 (unknown origin)


J Med Chem 56: 593-624 (2013)


Article DOI: 10.1021/jm3011433
BindingDB Entry DOI: 10.7270/Q23B61GZ
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50019900
PNG
(CHEMBL3287205 | US9533999, i-5)
Show SMILES Fc1ccc(CN2C(=O)CS(=O)(=O)c3cccnc23)cc1OC(F)(F)F
Show InChI InChI=1S/C15H10F4N2O4S/c16-10-4-3-9(6-11(10)25-15(17,18)19)7-21-13(22)8-26(23,24)12-2-1-5-20-14(12)21/h1-6H,7-8H2
PDB

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n/an/a 49n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition...


ACS Med Chem Lett 5: 460-1 (2014)


Article DOI: 10.1021/ml500090s
BindingDB Entry DOI: 10.7270/Q2RJ4M2T
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50019901
PNG
(CHEMBL3287206 | US9533999, i-34)
Show SMILES CC(C)c1nc2N(Cc3ccc(F)c(OC(F)(F)F)c3)C(=O)CS(=O)(=O)c2s1
Show InChI InChI=1S/C16H14F4N2O4S2/c1-8(2)14-21-13-15(27-14)28(24,25)7-12(23)22(13)6-9-3-4-10(17)11(5-9)26-16(18,19)20/h3-5,8H,6-7H2,1-2H3
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n/an/a 96n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition...


ACS Med Chem Lett 5: 460-1 (2014)


Article DOI: 10.1021/ml500090s
BindingDB Entry DOI: 10.7270/Q2RJ4M2T
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50019902
PNG
(CHEMBL3287207)
Show SMILES CC(N1c2sccc2S(=O)(=O)CC1=O)c1ccc(F)c(OC(F)(F)F)c1
Show InChI InChI=1S/C15H11F4NO4S2/c1-8(9-2-3-10(16)11(6-9)24-15(17,18)19)20-13(21)7-26(22,23)12-4-5-25-14(12)20/h2-6,8H,7H2,1H3
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n/an/a 39n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition...


ACS Med Chem Lett 5: 460-1 (2014)


Article DOI: 10.1021/ml500090s
BindingDB Entry DOI: 10.7270/Q2RJ4M2T
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50019903
PNG
(CHEMBL3287208 | US9533999, i-40)
Show SMILES Fc1ccc(CN2c3ccsc3S(=O)(=O)CC2=O)cc1OC(F)(F)F
Show InChI InChI=1S/C14H9F4NO4S2/c15-9-2-1-8(5-11(9)23-14(16,17)18)6-19-10-3-4-24-13(10)25(21,22)7-12(19)20/h1-5H,6-7H2
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n/an/a 48n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition...


ACS Med Chem Lett 5: 460-1 (2014)


Article DOI: 10.1021/ml500090s
BindingDB Entry DOI: 10.7270/Q2RJ4M2T
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50019904
PNG
(CHEMBL3287209 | US9533999, ii-1)
Show SMILES FC(F)(F)Oc1cccc(CN2C(=O)CSc3cccnc23)c1
Show InChI InChI=1S/C15H11F3N2O2S/c16-15(17,18)22-11-4-1-3-10(7-11)8-20-13(21)9-23-12-5-2-6-19-14(12)20/h1-7H,8-9H2
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n/an/a 52n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition...


ACS Med Chem Lett 5: 460-1 (2014)


Article DOI: 10.1021/ml500090s
BindingDB Entry DOI: 10.7270/Q2RJ4M2T
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50019905
PNG
(CHEMBL3287210 | US9533999, ii-4)
Show SMILES CC(N1C(=O)CSc2cccnc12)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C16H13F3N2OS/c1-10(11-4-2-5-12(8-11)16(17,18)19)21-14(22)9-23-13-6-3-7-20-15(13)21/h2-8,10H,9H2,1H3
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n/an/a 41n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition...


ACS Med Chem Lett 5: 460-1 (2014)


Article DOI: 10.1021/ml500090s
BindingDB Entry DOI: 10.7270/Q2RJ4M2T
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50019906
PNG
(CHEMBL3287211 | US9533999, ii-11)
Show SMILES OCc1ccc2SCC(=O)N(Cc3ccc(Cl)c(c3)C(F)(F)F)c2n1
Show InChI InChI=1S/C16H12ClF3N2O2S/c17-12-3-1-9(5-11(12)16(18,19)20)6-22-14(24)8-25-13-4-2-10(7-23)21-15(13)22/h1-5,23H,6-8H2
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n/an/a 66n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition...


ACS Med Chem Lett 5: 460-1 (2014)


Article DOI: 10.1021/ml500090s
BindingDB Entry DOI: 10.7270/Q2RJ4M2T
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens)
BDBM50019907
PNG
(CHEMBL3287212)
Show SMILES CC(N1c2scnc2SCC1=O)c1ccc(F)c(OC(F)(F)F)c1
Show InChI InChI=1S/C14H10F4N2O2S2/c1-7(20-11(21)5-23-12-13(20)24-6-19-12)8-2-3-9(15)10(4-8)22-14(16,17)18/h2-4,6-7H,5H2,1H3
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n/an/a 60n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition...


ACS Med Chem Lett 5: 460-1 (2014)


Article DOI: 10.1021/ml500090s
BindingDB Entry DOI: 10.7270/Q2RJ4M2T
More data for this
Ligand-Target Pair
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