BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 832 hits Enz. Inhib. hit(s) with Target = 'Intestinal alkaline phosphatase'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Intestinal alkaline phosphatase


(Bos taurus (Cattle))
BDBM50150071
PNG
(CHEMBL3774946)
Show SMILES OC(Cn1ccsc1=N)c1cc2ccccc2o1
Show InChI InChI=1S/C13H12N2O2S/c14-13-15(5-6-18-13)8-10(16)12-7-9-3-1-2-4-11(9)17-12/h1-7,10,14,16H,8H2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>4.00E+5n/an/an/an/a7.8n/a



Universit£ de Lyon

Curated by ChEMBL


Assay Description
Inhibition of bovine intestinal alkaline phosphatase using para-nitrophenylphosphate as substrate preincubated for 10 mins at pH 10.4 followed by sub...


Bioorg Med Chem Lett 26: 1457-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.061
BindingDB Entry DOI: 10.7270/Q23N2572
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase


(Bos taurus (Cattle))
BDBM50150070
PNG
(CHEMBL3774470)
Show SMILES C1C(N=C2SC=CN12)c1cc2ccccc2o1
Show InChI InChI=1S/C13H10N2OS/c1-2-4-11-9(3-1)7-12(16-11)10-8-15-5-6-17-13(15)14-10/h1-7,10H,8H2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>4.00E+5n/an/an/an/a7.8n/a



Universit£ de Lyon

Curated by ChEMBL


Assay Description
Inhibition of bovine intestinal alkaline phosphatase using para-nitrophenylphosphate as substrate preincubated for 10 mins at pH 7.8 followed by subs...


Bioorg Med Chem Lett 26: 1457-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.061
BindingDB Entry DOI: 10.7270/Q23N2572
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase


(Bos taurus (Cattle))
BDBM50241179
PNG
((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...)
Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1
Show InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>4.00E+5n/an/an/an/a7.8n/a



Universit£ de Lyon

Curated by ChEMBL


Assay Description
Inhibition of bovine intestinal alkaline phosphatase using para-nitrophenylphosphate as substrate preincubated for 10 mins at pH 7.8 followed by subs...


Bioorg Med Chem Lett 26: 1457-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.061
BindingDB Entry DOI: 10.7270/Q23N2572
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase


(Bos taurus (Cattle))
BDBM50150089
PNG
(CHEMBL3774723)
Show SMILES N=c1sccn1CC(=O)c1cc2ccccc2o1
Show InChI InChI=1S/C13H10N2O2S/c14-13-15(5-6-18-13)8-10(16)12-7-9-3-1-2-4-11(9)17-12/h1-7,14H,8H2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>4.00E+5n/an/an/an/a7.8n/a



Universit£ de Lyon

Curated by ChEMBL


Assay Description
Inhibition of bovine intestinal alkaline phosphatase using para-nitrophenylphosphate as substrate preincubated for 10 mins at pH 7.8 followed by subs...


Bioorg Med Chem Lett 26: 1457-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.061
BindingDB Entry DOI: 10.7270/Q23N2572
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM50150071
PNG
(CHEMBL3774946)
Show SMILES OC(Cn1ccsc1=N)c1cc2ccccc2o1
Show InChI InChI=1S/C13H12N2O2S/c14-13-15(5-6-18-13)8-10(16)12-7-9-3-1-2-4-11(9)17-12/h1-7,10,14,16H,8H2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>4.00E+5n/an/an/an/a7.8n/a



Universit£ de Lyon

Curated by ChEMBL


Assay Description
Inhibition of bovine intestinal alkaline phosphatase using para-nitrophenylphosphate as substrate preincubated for 10 mins at pH 7.8 followed by subs...


Bioorg Med Chem Lett 26: 1457-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.061
BindingDB Entry DOI: 10.7270/Q23N2572
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM223075
PNG
((E)-N'-(2'-hydroxybenzylidene)isonicotinoh...)
Show SMILES Oc1ccccc1\C=N\NC(=O)c1ccncc1
Show InChI InChI=1S/C13H11N3O2/c17-12-4-2-1-3-11(12)9-15-16-13(18)10-5-7-14-8-6-10/h1-9,17H,(H,16,18)/b15-9+
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.44E+3n/an/an/an/a9.837



Quaid-I-Azam University



Assay Description
The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...


Chem Biol Drug Des 89: 365-370 (2017)


Article DOI: 10.1111/cbdd.12861
BindingDB Entry DOI: 10.7270/Q2F47N10
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM223076
PNG
((E)-N'-(3'-Nitrobenzylidene)isonicotinohyd...)
Show SMILES [O-][N+](=O)c1cccc(\C=N\NC(=O)c2ccncc2)c1
Show InChI InChI=1S/C13H10N4O3/c18-13(11-4-6-14-7-5-11)16-15-9-10-2-1-3-12(8-10)17(19)20/h1-9H,(H,16,18)/b15-9+
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7.34E+3n/an/an/an/a9.837



Quaid-I-Azam University



Assay Description
The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...


Chem Biol Drug Des 89: 365-370 (2017)


Article DOI: 10.1111/cbdd.12861
BindingDB Entry DOI: 10.7270/Q2F47N10
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM223077
PNG
((E)-N'-(4'-Hydroxy-3-methoxybenzylidene)is...)
Show SMILES COc1cc(\C=N\NC(=O)c2ccncc2)ccc1O
Show InChI InChI=1S/C14H13N3O3/c1-20-13-8-10(2-3-12(13)18)9-16-17-14(19)11-4-6-15-7-5-11/h2-9,18H,1H3,(H,17,19)/b16-9+
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.92E+3n/an/an/an/a9.837



Quaid-I-Azam University



Assay Description
The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...


Chem Biol Drug Des 89: 365-370 (2017)


Article DOI: 10.1111/cbdd.12861
BindingDB Entry DOI: 10.7270/Q2F47N10
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM223078
PNG
((E)-N'-(Pyridin-4'-ylmethylene)isonicotino...)
Show SMILES O=C(N\N=C\c1ccncc1)c1ccncc1
Show InChI InChI=1S/C12H10N4O/c17-12(11-3-7-14-8-4-11)16-15-9-10-1-5-13-6-2-10/h1-9H,(H,16,17)/b15-9+
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.46E+3n/an/an/an/a9.837



Quaid-I-Azam University



Assay Description
The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...


Chem Biol Drug Des 89: 365-370 (2017)


Article DOI: 10.1111/cbdd.12861
BindingDB Entry DOI: 10.7270/Q2F47N10
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM223079
PNG
((E)-N'-(Pyridin-3'-ylmethylene)isonicotino...)
Show SMILES O=C(N\N=C\c1cccnc1)c1ccncc1
Show InChI InChI=1S/C12H10N4O/c17-12(11-3-6-13-7-4-11)16-15-9-10-2-1-5-14-8-10/h1-9H,(H,16,17)/b15-9+
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.46E+3n/an/an/an/a9.837



Quaid-I-Azam University



Assay Description
The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...


Chem Biol Drug Des 89: 365-370 (2017)


Article DOI: 10.1111/cbdd.12861
BindingDB Entry DOI: 10.7270/Q2F47N10
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM223080
PNG
((E)-N'-(1-(3-(4-fluorophenyl)-5-phenyl-4,5-dih...)
Show SMILES C\C(=N/NC(=O)c1ccncc1)N1N=C(CC1c1ccccc1)c1ccc(F)cc1
Show InChI InChI=1S/C23H20FN5O/c1-16(26-27-23(30)19-11-13-25-14-12-19)29-22(18-5-3-2-4-6-18)15-21(28-29)17-7-9-20(24)10-8-17/h2-14,22H,15H2,1H3,(H,27,30)/b26-16+
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.98E+3n/an/an/an/a9.837



Quaid-I-Azam University



Assay Description
The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...


Chem Biol Drug Des 89: 365-370 (2017)


Article DOI: 10.1111/cbdd.12861
BindingDB Entry DOI: 10.7270/Q2F47N10
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM18073
PNG
((2S)-2-amino-3-phenylpropanoic acid | CHEMBL301523...)
Show SMILES N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/a 8.02E+4n/an/an/an/a9.837



Quaid-I-Azam University



Assay Description
The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...


Chem Biol Drug Des 89: 365-370 (2017)


Article DOI: 10.1111/cbdd.12861
BindingDB Entry DOI: 10.7270/Q2F47N10
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM222258
PNG
((Z)-4-(2-((E)-4-(2-chlorophenyl)-1-morpholino-2-ox...)
Show SMILES NS(=O)(=O)c1ccc(N\N=C(/N2CCOCC2)C(=O)\C=C\c2ccccc2Cl)cc1
Show InChI InChI=1S/C20H21ClN4O4S/c21-18-4-2-1-3-15(18)5-10-19(26)20(25-11-13-29-14-12-25)24-23-16-6-8-17(9-7-16)30(22,27)28/h1-10,23H,11-14H2,(H2,22,27,28)/b10-5+,24-20-
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 120n/an/an/an/a9.837



COMSATS Institute of Information Technology



Assay Description
Alkaline phosphatase assay was optimized and performed in the same way as previously reported method with slight modifications [Sergienko et al., Nat...


Bioorg Chem 70: 229-236 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.003
BindingDB Entry DOI: 10.7270/Q2K07334
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM222259
PNG
((Z)-4-(2-((E)-4-(2,4-dichlorophenyl)-1-morpholino-...)
Show SMILES NS(=O)(=O)c1ccc(N\N=C(/N2CCOCC2)C(=O)\C=C\c2ccc(Cl)cc2Cl)cc1
Show InChI InChI=1S/C20H20Cl2N4O4S/c21-15-3-1-14(18(22)13-15)2-8-19(27)20(26-9-11-30-12-10-26)25-24-16-4-6-17(7-5-16)31(23,28)29/h1-8,13,24H,9-12H2,(H2,23,28,29)/b8-2+,25-20-
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 680n/an/an/an/a9.837



COMSATS Institute of Information Technology



Assay Description
Alkaline phosphatase assay was optimized and performed in the same way as previously reported method with slight modifications [Sergienko et al., Nat...


Bioorg Chem 70: 229-236 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.003
BindingDB Entry DOI: 10.7270/Q2K07334
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM222260
PNG
((Z)-4-(2-((E)-4-(3-methoxyphenyl)-1-morpholino-2-o...)
Show SMILES COc1cccc(\C=C\C(=O)C(=N\Nc2ccc(cc2)S(N)(=O)=O)\N2CCOCC2)c1
Show InChI InChI=1S/C21H24N4O5S/c1-29-18-4-2-3-16(15-18)5-10-20(26)21(25-11-13-30-14-12-25)24-23-17-6-8-19(9-7-17)31(22,27)28/h2-10,15,23H,11-14H2,1H3,(H2,22,27,28)/b10-5+,24-21-
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 990n/an/an/an/a9.837



COMSATS Institute of Information Technology



Assay Description
Alkaline phosphatase assay was optimized and performed in the same way as previously reported method with slight modifications [Sergienko et al., Nat...


Bioorg Chem 70: 229-236 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.003
BindingDB Entry DOI: 10.7270/Q2K07334
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM222261
PNG
((Z)-4-(2-((E)-4-(4-methoxyphenyl)-1-morpholino-2-o...)
Show SMILES COc1ccc(\C=C\C(=O)C(=N\Nc2ccc(cc2)S(N)(=O)=O)\N2CCOCC2)cc1
Show InChI InChI=1S/C21H24N4O5S/c1-29-18-7-2-16(3-8-18)4-11-20(26)21(25-12-14-30-15-13-25)24-23-17-5-9-19(10-6-17)31(22,27)28/h2-11,23H,12-15H2,1H3,(H2,22,27,28)/b11-4+,24-21-
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.71E+3n/an/an/an/a9.837



COMSATS Institute of Information Technology



Assay Description
Alkaline phosphatase assay was optimized and performed in the same way as previously reported method with slight modifications [Sergienko et al., Nat...


Bioorg Chem 70: 229-236 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.003
BindingDB Entry DOI: 10.7270/Q2K07334
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM222262
PNG
((Z)-4-(2-((E)-4-(3,4-dimethoxyphenyl)-1-morpholino...)
Show SMILES COc1ccc(\C=C\C(=O)C(=N\Nc2ccc(cc2)S(N)(=O)=O)\N2CCOCC2)cc1OC
Show InChI InChI=1S/C22H26N4O6S/c1-30-20-10-4-16(15-21(20)31-2)3-9-19(27)22(26-11-13-32-14-12-26)25-24-17-5-7-18(8-6-17)33(23,28)29/h3-10,15,24H,11-14H2,1-2H3,(H2,23,28,29)/b9-3+,25-22-
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 350n/an/an/an/a9.837



COMSATS Institute of Information Technology



Assay Description
Alkaline phosphatase assay was optimized and performed in the same way as previously reported method with slight modifications [Sergienko et al., Nat...


Bioorg Chem 70: 229-236 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.003
BindingDB Entry DOI: 10.7270/Q2K07334
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM222263
PNG
((Z)-4-(2-((E)-1-morpholino-2-oxo-4-(3,4,5-Trimetho...)
Show SMILES COc1cc(\C=C\C(=O)C(=N\Nc2ccc(cc2)S(N)(=O)=O)\N2CCOCC2)cc(OC)c1OC
Show InChI InChI=1S/C23H28N4O7S/c1-31-20-14-16(15-21(32-2)22(20)33-3)4-9-19(28)23(27-10-12-34-13-11-27)26-25-17-5-7-18(8-6-17)35(24,29)30/h4-9,14-15,25H,10-13H2,1-3H3,(H2,24,29,30)/b9-4+,26-23-
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.57E+3n/an/an/an/a9.837



COMSATS Institute of Information Technology



Assay Description
Alkaline phosphatase assay was optimized and performed in the same way as previously reported method with slight modifications [Sergienko et al., Nat...


Bioorg Chem 70: 229-236 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.003
BindingDB Entry DOI: 10.7270/Q2K07334
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM222264
PNG
((Z)-4-(2-((E)-4-(2-fluorophenyl)-1-morpholino-2-ox...)
Show SMILES NS(=O)(=O)c1ccc(N\N=C(/N2CCOCC2)C(=O)\C=C\c2ccccc2F)cc1
Show InChI InChI=1S/C20H21FN4O4S/c21-18-4-2-1-3-15(18)5-10-19(26)20(25-11-13-29-14-12-25)24-23-16-6-8-17(9-7-16)30(22,27)28/h1-10,23H,11-14H2,(H2,22,27,28)/b10-5+,24-20-
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 440n/an/an/an/a9.837



COMSATS Institute of Information Technology



Assay Description
Alkaline phosphatase assay was optimized and performed in the same way as previously reported method with slight modifications [Sergienko et al., Nat...


Bioorg Chem 70: 229-236 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.003
BindingDB Entry DOI: 10.7270/Q2K07334
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM222265
PNG
((Z)-4-(2-((E)-4-(3-fluorophenyl)-1-morpholino-2-ox...)
Show SMILES NS(=O)(=O)c1ccc(N\N=C(/N2CCOCC2)C(=O)\C=C\c2cccc(F)c2)cc1
Show InChI InChI=1S/C20H21FN4O4S/c21-16-3-1-2-15(14-16)4-9-19(26)20(25-10-12-29-13-11-25)24-23-17-5-7-18(8-6-17)30(22,27)28/h1-9,14,23H,10-13H2,(H2,22,27,28)/b9-4+,24-20-
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 730n/an/an/an/a9.837



COMSATS Institute of Information Technology



Assay Description
Alkaline phosphatase assay was optimized and performed in the same way as previously reported method with slight modifications [Sergienko et al., Nat...


Bioorg Chem 70: 229-236 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.003
BindingDB Entry DOI: 10.7270/Q2K07334
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM222266
PNG
((Z)-4-(2-((E)-4-(2-bromophenyl)-1-morpholino-2-oxo...)
Show SMILES NS(=O)(=O)c1ccc(N\N=C(/N2CCOCC2)C(=O)\C=C\c2ccccc2Br)cc1
Show InChI InChI=1S/C20H21BrN4O4S/c21-18-4-2-1-3-15(18)5-10-19(26)20(25-11-13-29-14-12-25)24-23-16-6-8-17(9-7-16)30(22,27)28/h1-10,23H,11-14H2,(H2,22,27,28)/b10-5+,24-20-
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.21E+3n/an/an/an/a9.837



COMSATS Institute of Information Technology



Assay Description
Alkaline phosphatase assay was optimized and performed in the same way as previously reported method with slight modifications [Sergienko et al., Nat...


Bioorg Chem 70: 229-236 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.003
BindingDB Entry DOI: 10.7270/Q2K07334
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM222267
PNG
((Z)-4-(2-((E)-1-morpholino-4-(3-Nitrophenyl)-2-oxo...)
Show SMILES NS(=O)(=O)c1ccc(N\N=C(/N2CCOCC2)C(=O)\C=C\c2cccc(c2)[N+]([O-])=O)cc1
Show InChI InChI=1S/C20H21N5O6S/c21-32(29,30)18-7-5-16(6-8-18)22-23-20(24-10-12-31-13-11-24)19(26)9-4-15-2-1-3-17(14-15)25(27)28/h1-9,14,22H,10-13H2,(H2,21,29,30)/b9-4+,23-20-
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 740n/an/an/an/a9.837



COMSATS Institute of Information Technology



Assay Description
Alkaline phosphatase assay was optimized and performed in the same way as previously reported method with slight modifications [Sergienko et al., Nat...


Bioorg Chem 70: 229-236 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.003
BindingDB Entry DOI: 10.7270/Q2K07334
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM18073
PNG
((2S)-2-amino-3-phenylpropanoic acid | CHEMBL301523...)
Show SMILES N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/a 8.02E+4n/an/an/an/a9.837



COMSATS Institute of Information Technology



Assay Description
Alkaline phosphatase assay was optimized and performed in the same way as previously reported method with slight modifications [Sergienko et al., Nat...


Bioorg Chem 70: 229-236 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.003
BindingDB Entry DOI: 10.7270/Q2K07334
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM223074
PNG
((E)-N'-(4'-Methoxybenzylidene)isonicotinoh...)
Show SMILES COc1ccc(\C=N\NC(=O)c2ccncc2)cc1
Show InChI InChI=1S/C14H13N3O2/c1-19-13-4-2-11(3-5-13)10-16-17-14(18)12-6-8-15-9-7-12/h2-10H,1H3,(H,17,18)/b16-10+
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.74E+3n/an/an/an/a9.837



Quaid-I-Azam University



Assay Description
The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...


Chem Biol Drug Des 89: 365-370 (2017)


Article DOI: 10.1111/cbdd.12861
BindingDB Entry DOI: 10.7270/Q2F47N10
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM223073
PNG
((E)-N'-(4'-Fluorobenzylidene)isonicotinohy...)
Show SMILES Fc1ccc(\C=N\NC(=O)c2ccncc2)cc1
Show InChI InChI=1S/C13H10FN3O/c14-12-3-1-10(2-4-12)9-16-17-13(18)11-5-7-15-8-6-11/h1-9H,(H,17,18)/b16-9+
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.75E+4n/an/an/an/a9.837



Quaid-I-Azam University



Assay Description
The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...


Chem Biol Drug Des 89: 365-370 (2017)


Article DOI: 10.1111/cbdd.12861
BindingDB Entry DOI: 10.7270/Q2F47N10
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM223072
PNG
((E)-N'-(4'-Bromobenzylidene)isonicotinohyd...)
Show SMILES Brc1ccc(\C=N\NC(=O)c2ccncc2)cc1
Show InChI InChI=1S/C13H10BrN3O/c14-12-3-1-10(2-4-12)9-16-17-13(18)11-5-7-15-8-6-11/h1-9H,(H,17,18)/b16-9+
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 9.72E+3n/an/an/an/a9.837



Quaid-I-Azam University



Assay Description
The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...


Chem Biol Drug Des 89: 365-370 (2017)


Article DOI: 10.1111/cbdd.12861
BindingDB Entry DOI: 10.7270/Q2F47N10
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM223071
PNG
((E)-N'-(4'-Chlorobenzylidene)isonicotinohy...)
Show SMILES Clc1ccc(\C=N\NC(=O)c2ccncc2)cc1
Show InChI InChI=1S/C13H10ClN3O/c14-12-3-1-10(2-4-12)9-16-17-13(18)11-5-7-15-8-6-11/h1-9H,(H,17,18)/b16-9+
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 670n/an/an/an/a9.837



Quaid-I-Azam University



Assay Description
The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...


Chem Biol Drug Des 89: 365-370 (2017)


Article DOI: 10.1111/cbdd.12861
BindingDB Entry DOI: 10.7270/Q2F47N10
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM222179
PNG
(6-(Dimethylamino)-3-phenyl-2,3-dihydronaphtho[1,8-...)
Show SMILES CN(C)c1ccc2C(NS(=O)(=O)c3cccc1c23)c1ccccc1
Show InChI InChI=1S/C19H18N2O2S/c1-21(2)16-12-11-15-18-14(16)9-6-10-17(18)24(22,23)20-19(15)13-7-4-3-5-8-13/h3-12,19-20H,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.12E+3n/an/an/an/a9.837



University of Karachi



Assay Description
Alkaline phosphatase (b-TNAP, c-IAP purchased from Calzyme Laboratories, Inc. USA) inhibition assay of different cyclic sulfonamides was performed us...


Bioorg Chem 71: 10-18 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.008
BindingDB Entry DOI: 10.7270/Q26Q1W36
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM222185
PNG
(6-(Dimethylamino)-3-(3',5'-dichloro-2-hydr...)
Show SMILES CN(C)c1ccc2C(NS(=O)(=O)c3cccc1c23)c1cc(Cl)cc(Cl)c1O
Show InChI InChI=1S/C19H16Cl2N2O3S/c1-23(2)15-7-6-12-17-11(15)4-3-5-16(17)27(25,26)22-18(12)13-8-10(20)9-14(21)19(13)24/h3-9,18,22,24H,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 380n/an/an/an/a9.837



University of Karachi



Assay Description
Alkaline phosphatase (b-TNAP, c-IAP purchased from Calzyme Laboratories, Inc. USA) inhibition assay of different cyclic sulfonamides was performed us...


Bioorg Chem 71: 10-18 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.008
BindingDB Entry DOI: 10.7270/Q26Q1W36
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM50241179
PNG
((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...)
Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1
Show InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>4.00E+5n/an/an/an/a10.4n/a



Universit£ de Lyon

Curated by ChEMBL


Assay Description
Inhibition of bovine intestinal alkaline phosphatase using para-nitrophenylphosphate as substrate preincubated for 10 mins at pH 10.4 followed by sub...


Bioorg Med Chem Lett 26: 1457-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.061
BindingDB Entry DOI: 10.7270/Q23N2572
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM50150089
PNG
(CHEMBL3774723)
Show SMILES N=c1sccn1CC(=O)c1cc2ccccc2o1
Show InChI InChI=1S/C13H10N2O2S/c14-13-15(5-6-18-13)8-10(16)12-7-9-3-1-2-4-11(9)17-12/h1-7,14H,8H2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>4.00E+5n/an/an/an/a10.4n/a



Universit£ de Lyon

Curated by ChEMBL


Assay Description
Inhibition of bovine intestinal alkaline phosphatase using para-nitrophenylphosphate as substrate preincubated for 10 mins at pH 10.4 followed by sub...


Bioorg Med Chem Lett 26: 1457-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.061
BindingDB Entry DOI: 10.7270/Q23N2572
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM50150070
PNG
(CHEMBL3774470)
Show SMILES C1C(N=C2SC=CN12)c1cc2ccccc2o1
Show InChI InChI=1S/C13H10N2OS/c1-2-4-11-9(3-1)7-12(16-11)10-8-15-5-6-17-13(15)14-10/h1-7,10H,8H2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>4.00E+5n/an/an/an/a10.4n/a



Universit£ de Lyon

Curated by ChEMBL


Assay Description
Inhibition of bovine intestinal alkaline phosphatase using para-nitrophenylphosphate as substrate preincubated for 10 mins at pH 10.4 followed by sub...


Bioorg Med Chem Lett 26: 1457-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.061
BindingDB Entry DOI: 10.7270/Q23N2572
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM50437932
PNG
(CHEMBL2408704)
Show SMILES CCOC1Oc2ccc(F)cc2C(=O)C1=CNc1ccc(cc1)S(=O)(=O)Nc1nnc(C)s1
Show InChI InChI=1S/C21H19FN4O5S2/c1-3-30-20-17(19(27)16-10-13(22)4-9-18(16)31-20)11-23-14-5-7-15(8-6-14)33(28,29)26-21-25-24-12(2)32-21/h4-11,20,23H,3H2,1-2H3,(H,25,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
10n/an/an/an/an/an/an/an/a



Forman Christian College (A Chartered University)

Curated by ChEMBL


Assay Description
Inhibition of bovine intestinal alkaline phosphatase using p-NPP as substrate treated 10 mins before substrate addition measured after 30 mins by spe...


Eur J Med Chem 66: 438-49 (2013)


Article DOI: 10.1016/j.ejmech.2013.06.015
BindingDB Entry DOI: 10.7270/Q20K29ZH
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM50437935
PNG
(CHEMBL2408701)
Show SMILES Brc1ccc2occ(C3Nc4ccccc4S(=O)(=O)N3)c(=O)c2c1
Show InChI InChI=1S/C16H11BrN2O4S/c17-9-5-6-13-10(7-9)15(20)11(8-23-13)16-18-12-3-1-2-4-14(12)24(21,22)19-16/h1-8,16,18-19H
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
21n/an/an/an/an/an/an/an/a



Forman Christian College (A Chartered University)

Curated by ChEMBL


Assay Description
Inhibition of bovine intestinal alkaline phosphatase using p-NPP as substrate treated 10 mins before substrate addition measured after 30 mins by spe...


Eur J Med Chem 66: 438-49 (2013)


Article DOI: 10.1016/j.ejmech.2013.06.015
BindingDB Entry DOI: 10.7270/Q20K29ZH
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM50437937
PNG
(CHEMBL2408699)
Show SMILES O=c1c(coc2ccccc12)C1Nc2ccccc2S(=O)(=O)N1
Show InChI InChI=1S/C16H12N2O4S/c19-15-10-5-1-3-7-13(10)22-9-11(15)16-17-12-6-2-4-8-14(12)23(20,21)18-16/h1-9,16-18H
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
49n/an/an/an/an/an/an/an/a



Forman Christian College (A Chartered University)

Curated by ChEMBL


Assay Description
Inhibition of bovine intestinal alkaline phosphatase using p-NPP as substrate treated 10 mins before substrate addition measured after 30 mins by spe...


Eur J Med Chem 66: 438-49 (2013)


Article DOI: 10.1016/j.ejmech.2013.06.015
BindingDB Entry DOI: 10.7270/Q20K29ZH
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM50437931
PNG
(CHEMBL2408705)
Show SMILES CCOC1Oc2ccccc2C(=O)C1=CNc1ccc(cc1)S(=O)(=O)Nc1nnc(C)s1
Show InChI InChI=1S/C21H20N4O5S2/c1-3-29-20-17(19(26)16-6-4-5-7-18(16)30-20)12-22-14-8-10-15(11-9-14)32(27,28)25-21-24-23-13(2)31-21/h4-12,20,22H,3H2,1-2H3,(H,24,25)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
85n/an/an/an/an/an/an/an/a



Forman Christian College (A Chartered University)

Curated by ChEMBL


Assay Description
Inhibition of bovine intestinal alkaline phosphatase using p-NPP as substrate treated 10 mins before substrate addition measured after 30 mins by spe...


Eur J Med Chem 66: 438-49 (2013)


Article DOI: 10.1016/j.ejmech.2013.06.015
BindingDB Entry DOI: 10.7270/Q20K29ZH
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM50437934
PNG
(CHEMBL2408702)
Show SMILES CCOC1Oc2c(Br)cc(Br)cc2C(=O)C1=CNc1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C18H16Br2N2O5S/c1-2-26-18-12(9-22-14-5-3-4-6-15(14)28(21,24)25)16(23)11-7-10(19)8-13(20)17(11)27-18/h3-9,18,22H,2H2,1H3,(H2,21,24,25)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
200n/an/an/an/an/an/an/an/a



Forman Christian College (A Chartered University)

Curated by ChEMBL


Assay Description
Inhibition of bovine intestinal alkaline phosphatase using p-NPP as substrate treated 10 mins before substrate addition measured after 30 mins by spe...


Eur J Med Chem 66: 438-49 (2013)


Article DOI: 10.1016/j.ejmech.2013.06.015
BindingDB Entry DOI: 10.7270/Q20K29ZH
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM50322604
PNG
(2-mercaptophenylphosphonic acid | CHEMBL1173336)
Show SMILES OP(O)(=O)c1ccccc1S
Show InChI InChI=1S/C6H7O3PS/c7-10(8,9)5-3-1-2-4-6(5)11/h1-4,11H,(H2,7,8,9)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
210n/an/an/an/an/an/an/an/a



University of Li£ge

Curated by ChEMBL


Assay Description
Inhibition of bovine intestinal alkaline phosphatase


J Med Chem 53: 4862-76 (2010)


Article DOI: 10.1021/jm100213c
BindingDB Entry DOI: 10.7270/Q2057G34
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase


(Bos taurus (Cattle))
BDBM50165143
PNG
(CHEMBL3798555)
Show SMILES CC(C)OC1Oc2ccccc2C(=O)\C1=C/Nc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C19H20N2O5S/c1-12(2)25-19-16(18(22)15-5-3-4-6-17(15)26-19)11-21-13-7-9-14(10-8-13)27(20,23)24/h3-12,19,21H,1-2H3,(H2,20,23,24)/b16-11+
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
220n/an/an/an/an/an/an/an/a



Forman Christian College (A Chartered University)

Curated by ChEMBL


Assay Description
Inhibition of calf intestinal alkaline phosphatase preincubated for 3 to 5 mins followed by CDP-star substrate addition measured after 15 mins by lum...


Eur J Med Chem 115: 484-94 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.073
BindingDB Entry DOI: 10.7270/Q2K939D7
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase


(Bos taurus (Cattle))
BDBM50165128
PNG
(CHEMBL3799629)
Show SMILES COC1Oc2ccccc2C(=O)\C1=C/Nc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C17H16N2O5S/c1-23-17-14(16(20)13-4-2-3-5-15(13)24-17)10-19-11-6-8-12(9-7-11)25(18,21)22/h2-10,17,19H,1H3,(H2,18,21,22)/b14-10+
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
240n/an/an/an/an/an/an/an/a



Forman Christian College (A Chartered University)

Curated by ChEMBL


Assay Description
Inhibition of calf intestinal alkaline phosphatase preincubated for 3 to 5 mins followed by CDP-star substrate addition measured after 15 mins by lum...


Eur J Med Chem 115: 484-94 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.073
BindingDB Entry DOI: 10.7270/Q2K939D7
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM50437933
PNG
(CHEMBL2408703)
Show SMILES CCOC1Oc2ccc(CC)cc2C(=O)C1=CNc1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C20H22N2O5S/c1-3-13-9-10-17-14(11-13)19(23)15(20(27-17)26-4-2)12-22-16-7-5-6-8-18(16)28(21,24)25/h5-12,20,22H,3-4H2,1-2H3,(H2,21,24,25)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
400n/an/an/an/an/an/an/an/a



Forman Christian College (A Chartered University)

Curated by ChEMBL


Assay Description
Inhibition of bovine intestinal alkaline phosphatase using p-NPP as substrate treated 10 mins before substrate addition measured after 30 mins by spe...


Eur J Med Chem 66: 438-49 (2013)


Article DOI: 10.1016/j.ejmech.2013.06.015
BindingDB Entry DOI: 10.7270/Q20K29ZH
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM50437929
PNG
(CHEMBL2408560)
Show SMILES CCOC1Oc2ccccc2C(=O)C1=CNc1ccc(cc1)S(=O)(=O)Nc1ccccn1
Show InChI InChI=1S/C23H21N3O5S/c1-2-30-23-19(22(27)18-7-3-4-8-20(18)31-23)15-25-16-10-12-17(13-11-16)32(28,29)26-21-9-5-6-14-24-21/h3-15,23,25H,2H2,1H3,(H,24,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
410n/an/an/an/an/an/an/an/a



Forman Christian College (A Chartered University)

Curated by ChEMBL


Assay Description
Inhibition of bovine intestinal alkaline phosphatase using p-NPP as substrate treated 10 mins before substrate addition measured after 30 mins by spe...


Eur J Med Chem 66: 438-49 (2013)


Article DOI: 10.1016/j.ejmech.2013.06.015
BindingDB Entry DOI: 10.7270/Q20K29ZH
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM50437945
PNG
(CHEMBL1814393)
Show SMILES CCOC1Oc2ccc(Br)cc2C(=O)C1=CNc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C18H17BrN2O5S/c1-2-25-18-15(17(22)14-9-11(19)3-8-16(14)26-18)10-21-12-4-6-13(7-5-12)27(20,23)24/h3-10,18,21H,2H2,1H3,(H2,20,23,24)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
410n/an/an/an/an/an/an/an/a



Forman Christian College (A Chartered University)

Curated by ChEMBL


Assay Description
Inhibition of bovine intestinal alkaline phosphatase using p-NPP as substrate treated 10 mins before substrate addition measured after 30 mins by spe...


Eur J Med Chem 66: 438-49 (2013)


Article DOI: 10.1016/j.ejmech.2013.06.015
BindingDB Entry DOI: 10.7270/Q20K29ZH
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM50437936
PNG
(CHEMBL2408700)
Show SMILES Fc1ccc2occ(C3Nc4ccccc4S(=O)(=O)N3)c(=O)c2c1
Show InChI InChI=1S/C16H11FN2O4S/c17-9-5-6-13-10(7-9)15(20)11(8-23-13)16-18-12-3-1-2-4-14(12)24(21,22)19-16/h1-8,16,18-19H
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
780n/an/an/an/an/an/an/an/a



Forman Christian College (A Chartered University)

Curated by ChEMBL


Assay Description
Inhibition of bovine intestinal alkaline phosphatase using p-NPP as substrate treated 10 mins before substrate addition measured after 30 mins by spe...


Eur J Med Chem 66: 438-49 (2013)


Article DOI: 10.1016/j.ejmech.2013.06.015
BindingDB Entry DOI: 10.7270/Q20K29ZH
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM50437939
PNG
(CHEMBL1814399)
Show SMILES CCOC1Oc2c(Br)cc(Br)cc2C(=O)C1=CNc1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C18H16Br2N2O5S/c1-2-26-18-14(9-22-11-4-3-5-12(8-11)28(21,24)25)16(23)13-6-10(19)7-15(20)17(13)27-18/h3-9,18,22H,2H2,1H3,(H2,21,24,25)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
800n/an/an/an/an/an/an/an/a



Forman Christian College (A Chartered University)

Curated by ChEMBL


Assay Description
Inhibition of bovine intestinal alkaline phosphatase using p-NPP as substrate treated 10 mins before substrate addition measured after 30 mins by spe...


Eur J Med Chem 66: 438-49 (2013)


Article DOI: 10.1016/j.ejmech.2013.06.015
BindingDB Entry DOI: 10.7270/Q20K29ZH
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase


(Bos taurus (Cattle))
BDBM50165146
PNG
(CHEMBL3798795)
Show SMILES CCCCOC1Oc2ccccc2C(=O)\C1=C/Nc1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C20H22N2O5S/c1-2-3-11-26-20-17(19(23)16-9-4-5-10-18(16)27-20)13-22-14-7-6-8-15(12-14)28(21,24)25/h4-10,12-13,20,22H,2-3,11H2,1H3,(H2,21,24,25)/b17-13+
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
978n/an/an/an/an/an/an/an/a



Forman Christian College (A Chartered University)

Curated by ChEMBL


Assay Description
Inhibition of calf intestinal alkaline phosphatase preincubated for 3 to 5 mins followed by CDP-star substrate addition measured after 15 mins by lum...


Eur J Med Chem 115: 484-94 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.073
BindingDB Entry DOI: 10.7270/Q2K939D7
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase


(Bos taurus (Cattle))
BDBM50165150
PNG
(CHEMBL3799027)
Show SMILES COC1Oc2ccc(Cl)cc2C(=O)\C1=C/Nc1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C18H25NO2/c1-11-5-6-13(9-12(11)2)15-10-14-7-8-16(19(14)3)17(15)18(20)21-4/h5-6,9,14-17H,7-8,10H2,1-4H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
992n/an/an/an/an/an/an/an/a



Forman Christian College (A Chartered University)

Curated by ChEMBL


Assay Description
Inhibition of calf intestinal alkaline phosphatase preincubated for 3 to 5 mins followed by CDP-star substrate addition measured after 15 mins by lum...


Eur J Med Chem 115: 484-94 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.073
BindingDB Entry DOI: 10.7270/Q2K939D7
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase


(Bos taurus (Cattle))
BDBM50165138
PNG
(CHEMBL3798050)
Show SMILES COC1Oc2ccc(C)cc2C(=O)\C1=C/Nc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C18H18N2O5S/c1-11-3-8-16-14(9-11)17(21)15(18(24-2)25-16)10-20-12-4-6-13(7-5-12)26(19,22)23/h3-10,18,20H,1-2H3,(H2,19,22,23)/b15-10+
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.34E+3n/an/an/an/an/an/an/an/a



Forman Christian College (A Chartered University)

Curated by ChEMBL


Assay Description
Inhibition of calf intestinal alkaline phosphatase preincubated for 3 to 5 mins followed by CDP-star substrate addition measured after 15 mins by lum...


Eur J Med Chem 115: 484-94 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.073
BindingDB Entry DOI: 10.7270/Q2K939D7
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase


(Bos taurus (Cattle))
BDBM50165133
PNG
(CHEMBL3798620)
Show SMILES COC1Oc2c(Cl)cc(Cl)cc2C(=O)\C1=C/Nc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C17H14Cl2N2O5S/c1-25-17-13(8-21-10-2-4-11(5-3-10)27(20,23)24)15(22)12-6-9(18)7-14(19)16(12)26-17/h2-8,17,21H,1H3,(H2,20,23,24)/b13-8+
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.38E+3n/an/an/an/an/an/an/an/a



Forman Christian College (A Chartered University)

Curated by ChEMBL


Assay Description
Inhibition of calf intestinal alkaline phosphatase preincubated for 3 to 5 mins followed by CDP-star substrate addition measured after 15 mins by lum...


Eur J Med Chem 115: 484-94 (2016)


Article DOI: 10.1016/j.ejmech.2016.02.073
BindingDB Entry DOI: 10.7270/Q2K939D7
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM50437946
PNG
(CHEMBL1814392)
Show SMILES CCOC1Oc2ccc(F)cc2C(=O)C1=CNc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C18H17FN2O5S/c1-2-25-18-15(17(22)14-9-11(19)3-8-16(14)26-18)10-21-12-4-6-13(7-5-12)27(20,23)24/h3-10,18,21H,2H2,1H3,(H2,20,23,24)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.43E+3n/an/an/an/an/an/an/an/a



Forman Christian College (A Chartered University)

Curated by ChEMBL


Assay Description
Inhibition of bovine intestinal alkaline phosphatase using p-NPP as substrate treated 10 mins before substrate addition measured after 30 mins by spe...


Eur J Med Chem 66: 438-49 (2013)


Article DOI: 10.1016/j.ejmech.2013.06.015
BindingDB Entry DOI: 10.7270/Q20K29ZH
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 832 total )  |  Next  |  Last  >>
Jump to: