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Compile Data Set for Download or QSAR

Found 139 hits Enz. Inhib. hit(s) with Target = 'JAK1 (aa866-1154)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM50355501
PNG
(INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE ...)
Show SMILES N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1
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n/an/a 1n/an/an/an/a7.5n/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J...


US Patent US10112907 (2018)

More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM50021655
PNG
(DECERNOTINIB | US10112907, Example 00017 | VRT-831...)
Show SMILES CC[C@@](C)(Nc1ccnc(n1)-c1c[nH]c2ncccc12)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C18H19F3N6O/c1-3-17(2,16(28)25-10-18(19,20)21)27-13-6-8-23-15(26-13)12-9-24-14-11(12)5-4-7-22-14/h4-9H,3,10H2,1-2H3,(H,22,24)(H,25,28)(H,23,26,27)/t17-/m1/s1
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n/an/a 20n/an/an/an/a7.5n/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J...


US Patent US10112907 (2018)

More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM50332294
PNG
(CHEMBL1287853 | N-tert-butyl-3-(5-methyl-2-(4-(2-(...)
Show SMILES Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(c1)S(=O)(=O)NC(C)(C)C
Show InChI InChI=1S/C27H36N6O3S/c1-20-19-28-26(30-21-10-12-23(13-11-21)36-17-16-33-14-5-6-15-33)31-25(20)29-22-8-7-9-24(18-22)37(34,35)32-27(2,3)4/h7-13,18-19,32H,5-6,14-17H2,1-4H3,(H2,28,29,30,31)
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NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J...


US Patent US10112907 (2018)

More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM50311017
PNG
(CHEMBL1078178 | Momelotinib | N-(cyanomethyl)-4-(2...)
Show SMILES O=C(NCC#N)c1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Show InChI InChI=1S/C23H22N6O2/c24-10-12-25-22(30)18-3-1-17(2-4-18)21-9-11-26-23(28-21)27-19-5-7-20(8-6-19)29-13-15-31-16-14-29/h1-9,11H,12-16H2,(H,25,30)(H,26,27,28)
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NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J...


US Patent US10112907 (2018)

More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM294911
PNG
(US10112907, Example 00020)
Show SMILES C[C@H](Nc1ncc(Cl)c(Nc2cc(C)[nH]n2)n1)c1ncc(F)cn1
Show InChI InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1
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n/an/a 0.200n/an/an/an/a7.5n/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J...


US Patent US10112907 (2018)

More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM294912
PNG
(US10112907, Example 00021)
Show SMILES NC(=O)c1cn(nc1Nc1ccc(cc1)C(F)(F)F)[C@H]1CC[C@@H](O)C[C@@H]1[N+]#[C-]
Show InChI InChI=1S/C18H18F3N5O2/c1-23-14-8-12(27)6-7-15(14)26-9-13(16(22)28)17(25-26)24-11-4-2-10(3-5-11)18(19,20)21/h2-5,9,12,14-15,27H,6-8H2,(H2,22,28)(H,24,25)/t12-,14+,15+/m1/s1
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NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J...


US Patent US10112907 (2018)

More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM50193995
PNG
(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Show SMILES C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N
Show InChI InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1
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n/an/a 4n/an/an/an/a7.5n/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J...


US Patent US10112907 (2018)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM147692
PNG
(US10112907, Example 00025 | US8962608, 28-1)
Show SMILES NC(=O)c1cn(nc1Nc1ccc(cc1)C(F)(F)F)[C@H]1CC[C@@H](C[C@@H]1[N+]#[C-])N1CCC1
Show InChI InChI=1S/C21H23F3N6O/c1-26-17-11-15(29-9-2-10-29)7-8-18(17)30-12-16(19(25)31)20(28-30)27-14-5-3-13(4-6-14)21(22,23)24/h3-6,12,15,17-18H,2,7-11H2,(H2,25,31)(H,27,28)/t15-,17-,18-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J...


US Patent US10112907 (2018)

More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM294915
PNG
(US10112907, Example 00026)
Show SMILES NC(=O)c1cn(nc1Nc1ccc(cc1)C(F)(F)F)[C@@H]1CC[C@H](C[C@H]1[N+]#[C-])N1CCC1
Show InChI InChI=1S/C21H23F3N6O/c1-26-17-11-15(29-9-2-10-29)7-8-18(17)30-12-16(19(25)31)20(28-30)27-14-5-3-13(4-6-14)21(22,23)24/h3-6,12,15,17-18H,2,7-11H2,(H2,25,31)(H,27,28)/t15-,17-,18-/m1/s1
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NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J...


US Patent US10112907 (2018)

More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM294916
PNG
(US10112907, Example 00027)
Show SMILES O=C(Nc1nc2cccc(-c3ccc(OCc4ccc(nc4)C#N)cc3)n2n1)C1CC1
Show InChI InChI=1S/C23H18N6O2/c24-12-18-9-4-15(13-25-18)14-31-19-10-7-16(8-11-19)20-2-1-3-21-26-23(28-29(20)21)27-22(30)17-5-6-17/h1-4,7-11,13,17H,5-6,14H2,(H,27,28,30)
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NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J...


US Patent US10112907 (2018)

More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM103727
PNG
(US10112907, Example 00033 | US8563545, 1)
Show SMILES O=C(Nc1nc2cccc(-c3ccc(CN4CCS(=O)(=O)CC4)cc3)n2n1)C1CC1
Show InChI InChI=1S/C21H23N5O3S/c27-20(17-8-9-17)23-21-22-19-3-1-2-18(26(19)24-21)16-6-4-15(5-7-16)14-25-10-12-30(28,29)13-11-25/h1-7,17H,8-14H2,(H,23,24,27)
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NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J...


US Patent US10112907 (2018)

More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM50021656
PNG
(BARICITINIB | INCB-028050 | LY-3009104 | US1011290...)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C16H17N7O2S/c1-2-26(24,25)22-9-16(10-22,4-5-17)23-8-12(7-21-23)14-13-3-6-18-15(13)20-11-19-14/h3,6-8,11H,2,4,9-10H2,1H3,(H,18,19,20)
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NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J...


US Patent US10112907 (2018)

More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM50402074
PNG
(CHEMBL2206059 | US10112907, Example 00024)
Show SMILES CS(=O)(=O)NCc1nc2cnc3[nH]ccc3c2n1[C@@H]1C[C@H]2CC[C@@H]1C2
Show InChI InChI=1S/C17H21N5O2S/c1-25(23,24)20-9-15-21-13-8-19-17-12(4-5-18-17)16(13)22(15)14-7-10-2-3-11(14)6-10/h4-5,8,10-11,14,20H,2-3,6-7,9H2,1H3,(H,18,19)/t10-,11+,14+/m0/s1
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NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J...


US Patent US10112907 (2018)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM228682
PNG
(US9346810, 128)
Show SMILES C#CCN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)C#N
Show InChI InChI=1S/C19H17N7/c1-2-8-26(17-4-3-14(10-20)11-22-17)15-6-9-25(12-15)19-16-5-7-21-18(16)23-13-24-19/h1,3-5,7,11,13,15H,6,8-9,12H2,(H,21,23,24)/t15-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...


US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM228683
PNG
(US9346810, 144)
Show SMILES CN([C@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)-c1ccncc1
Show InChI InChI=1S/C21H21N7/c1-27(19-3-2-16(12-24-19)15-4-8-22-9-5-15)17-7-11-28(13-17)21-18-6-10-23-20(18)25-14-26-21/h2-6,8-10,12,14,17H,7,11,13H2,1H3,(H,23,25,26)/t17-/m0/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...


US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM228684
PNG
(US9346810, 154)
Show SMILES CN([C@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccncn1
Show InChI InChI=1S/C15H17N7/c1-21(13-3-5-16-9-18-13)11-4-7-22(8-11)15-12-2-6-17-14(12)19-10-20-15/h2-3,5-6,9-11H,4,7-8H2,1H3,(H,17,19,20)/t11-/m0/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...


US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM228685
PNG
(US9346810, 155)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(C#N)c(C)n1
Show InChI InChI=1S/C18H19N7/c1-12-13(9-19)3-4-16(23-12)24(2)14-6-8-25(10-14)18-15-5-7-20-17(15)21-11-22-18/h3-5,7,11,14H,6,8,10H2,1-2H3,(H,20,21,22)/t14-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...


US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM228686
PNG
(US9346810, 161)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cc1F)-c1nnn[nH]1
Show InChI InChI=1S/C18H18FN9/c1-27(15-3-2-11(8-14(15)19)16-23-25-26-24-16)12-5-7-28(9-12)18-13-4-6-20-17(13)21-10-22-18/h2-4,6,8,10,12H,5,7,9H2,1H3,(H,20,21,22)(H,23,24,25,26)/t12-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...


US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM228687
PNG
(US9346810, 202)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cc1F)C(=O)NC[C@H](O)c1ccccc1
Show InChI InChI=1S/C26H27FN6O2/c1-32(19-10-12-33(15-19)25-20-9-11-28-24(20)30-16-31-25)22-8-7-18(13-21(22)27)26(35)29-14-23(34)17-5-3-2-4-6-17/h2-9,11,13,16,19,23,34H,10,12,14-15H2,1H3,(H,29,35)(H,28,30,31)/t19-,23+/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...


US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM228688
PNG
(US9346810, 214)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(NS(=O)(=O)C2=CCCS2)cn1
Show InChI InChI=1S/C20H23N7O2S2/c1-26(15-7-9-27(12-15)20-16-6-8-21-19(16)23-13-24-20)17-5-4-14(11-22-17)25-31(28,29)18-3-2-10-30-18/h3-6,8,11,13,15,25H,2,7,9-10,12H2,1H3,(H,21,23,24)/t15-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...


US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM228689
PNG
(US9346810, 215)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(NS(=O)(=O)c2cccnc2)cn1
Show InChI InChI=1S/C21H22N8O2S/c1-28(16-7-10-29(13-16)21-18-6-9-23-20(18)25-14-26-21)19-5-4-15(11-24-19)27-32(30,31)17-3-2-8-22-12-17/h2-6,8-9,11-12,14,16,27H,7,10,13H2,1H3,(H,23,25,26)/t16-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...


US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM228690
PNG
(US9346810, 217)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(NS(C)(=O)=O)cn1
Show InChI InChI=1S/C17H21N7O2S/c1-23(15-4-3-12(9-19-15)22-27(2,25)26)13-6-8-24(10-13)17-14-5-7-18-16(14)20-11-21-17/h3-5,7,9,11,13,22H,6,8,10H2,1-2H3,(H,18,20,21)/t13-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...


US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM228691
PNG
(US9346810, 218)
Show SMILES CC(C)S(=O)(=O)Nc1ccc(nc1)N(C)[C@@H]1CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C19H25N7O2S/c1-13(2)29(27,28)24-14-4-5-17(21-10-14)25(3)15-7-9-26(11-15)19-16-6-8-20-18(16)22-12-23-19/h4-6,8,10,12-13,15,24H,7,9,11H2,1-3H3,(H,20,22,23)/t15-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...


US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM228692
PNG
(US9346810, 219)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(NS(=O)(=O)Cc2ccccc2F)cn1
Show InChI InChI=1S/C23H24FN7O2S/c1-30(18-9-11-31(13-18)23-19-8-10-25-22(19)27-15-28-23)21-7-6-17(12-26-21)29-34(32,33)14-16-4-2-3-5-20(16)24/h2-8,10,12,15,18,29H,9,11,13-14H2,1H3,(H,25,27,28)/t18-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...


US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM228693
PNG
(US9346810, 233)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)S(=O)(=O)N[C@H]1[C@H](O)Cc2ccccc12
Show InChI InChI=1S/C25H27N7O3S/c1-31(17-9-11-32(14-17)25-20-8-10-26-24(20)28-15-29-25)22-7-6-18(13-27-22)36(34,35)30-23-19-5-3-2-4-16(19)12-21(23)33/h2-8,10,13,15,17,21,23,30,33H,9,11-12,14H2,1H3,(H,26,28,29)/t17-,21-,23-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...


US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM228640
PNG
(US10111875, Compound 234 | US9346810, 234)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)S(N)(=O)=O
Show InChI InChI=1S/C16H19N7O2S/c1-22(14-3-2-12(8-19-14)26(17,24)25)11-5-7-23(9-11)16-13-4-6-18-15(13)20-10-21-16/h2-4,6,8,10-11H,5,7,9H2,1H3,(H2,17,24,25)(H,18,20,21)/t11-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...


US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM228694
PNG
(US9346810, 236)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)S(=O)(=O)NC1CC1
Show InChI InChI=1S/C19H23N7O2S/c1-25(17-5-4-15(10-21-17)29(27,28)24-13-2-3-13)14-7-9-26(11-14)19-16-6-8-20-18(16)22-12-23-19/h4-6,8,10,12-14,24H,2-3,7,9,11H2,1H3,(H,20,22,23)/t14-/m1/s1
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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...


US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM228695
PNG
(US9346810, 237)
Show SMILES COCCNS(=O)(=O)c1ccc(nc1)N(C)[C@@H]1CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C19H25N7O3S/c1-25(17-4-3-15(11-21-17)30(27,28)24-8-10-29-2)14-6-9-26(12-14)19-16-5-7-20-18(16)22-13-23-19/h3-5,7,11,13-14,24H,6,8-10,12H2,1-2H3,(H,20,22,23)/t14-/m1/s1
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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...


US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM228696
PNG
(US9346810, 238)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)S(=O)(=O)NC(C)(C)C
Show InChI InChI=1S/C20H27N7O2S/c1-20(2,3)25-30(28,29)15-5-6-17(22-11-15)26(4)14-8-10-27(12-14)19-16-7-9-21-18(16)23-13-24-19/h5-7,9,11,13-14,25H,8,10,12H2,1-4H3,(H,21,23,24)/t14-/m1/s1
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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...


US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM228697
PNG
(US9346810, 239)
Show SMILES CNS(=O)(=O)c1ccc(nc1)N(C)[C@@H]1CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C17H21N7O2S/c1-18-27(25,26)13-3-4-15(20-9-13)23(2)12-6-8-24(10-12)17-14-5-7-19-16(14)21-11-22-17/h3-5,7,9,11-12,18H,6,8,10H2,1-2H3,(H,19,21,22)/t12-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...


US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM228698
PNG
(US9346810, 241)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)S(=O)(=O)NC[C@@H]1CCCO1
Show InChI InChI=1S/C21H27N7O3S/c1-27(15-7-9-28(13-15)21-18-6-8-22-20(18)24-14-25-21)19-5-4-17(12-23-19)32(29,30)26-11-16-3-2-10-31-16/h4-6,8,12,14-16,26H,2-3,7,9-11,13H2,1H3,(H,22,24,25)/t15-,16+/m1/s1
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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...


US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM228699
PNG
(US9346810, 242)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)S(=O)(=O)NC1COC1
Show InChI InChI=1S/C19H23N7O3S/c1-25(17-3-2-15(8-21-17)30(27,28)24-13-10-29-11-13)14-5-7-26(9-14)19-16-4-6-20-18(16)22-12-23-19/h2-4,6,8,12-14,24H,5,7,9-11H2,1H3,(H,20,22,23)/t14-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...


US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM228700
PNG
(US9346810, 243)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)S(=O)(=O)NCCO
Show InChI InChI=1S/C18H23N7O3S/c1-24(16-3-2-14(10-20-16)29(27,28)23-7-9-26)13-5-8-25(11-13)18-15-4-6-19-17(15)21-12-22-18/h2-4,6,10,12-13,23,26H,5,7-9,11H2,1H3,(H,19,21,22)/t13-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...


US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM228701
PNG
(US9346810, 245)
Show SMILES C[C@H](O)CNS(=O)(=O)c1ccc(nc1)N(C)[C@@H]1CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C19H25N7O3S/c1-13(27)9-24-30(28,29)15-3-4-17(21-10-15)25(2)14-6-8-26(11-14)19-16-5-7-20-18(16)22-12-23-19/h3-5,7,10,12-14,24,27H,6,8-9,11H2,1-2H3,(H,20,22,23)/t13-,14+/m0/s1
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HUTCHISON MEDIPHARMA LIMITED

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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...


US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM228702
PNG
(US9346810, 246)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)S(=O)(=O)NC1CCC[C@@H]1O
Show InChI InChI=1S/C21H27N7O3S/c1-27(14-8-10-28(12-14)21-16-7-9-22-20(16)24-13-25-21)19-6-5-15(11-23-19)32(30,31)26-17-3-2-4-18(17)29/h5-7,9,11,13-14,17-18,26,29H,2-4,8,10,12H2,1H3,(H,22,24,25)/t14-,17?,18+/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...


US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM228703
PNG
(US9346810, 247)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)S(=O)(=O)N1CCCC1
Show InChI InChI=1S/C20H25N7O2S/c1-25(18-5-4-16(12-22-18)30(28,29)27-9-2-3-10-27)15-7-11-26(13-15)20-17-6-8-21-19(17)23-14-24-20/h4-6,8,12,14-15H,2-3,7,9-11,13H2,1H3,(H,21,23,24)/t15-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...


US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM228704
PNG
(US9346810, 251)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)S(=O)(=O)N1CCNCC1
Show InChI InChI=1S/C20H26N8O2S/c1-26(15-5-9-27(13-15)20-17-4-6-22-19(17)24-14-25-20)18-3-2-16(12-23-18)31(29,30)28-10-7-21-8-11-28/h2-4,6,12,14-15,21H,5,7-11,13H2,1H3,(H,22,24,25)/t15-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...


US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM228705
PNG
(US9346810, 252)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)S(=O)(=O)N1CCOCC1
Show InChI InChI=1S/C20H25N7O3S/c1-25(15-5-7-26(13-15)20-17-4-6-21-19(17)23-14-24-20)18-3-2-16(12-22-18)31(28,29)27-8-10-30-11-9-27/h2-4,6,12,14-15H,5,7-11,13H2,1H3,(H,21,23,24)/t15-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...


US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM228706
PNG
(US9346810, 253)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)S(=O)(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C22H22FN7O2S/c1-29(17-9-11-30(13-17)22-19-8-10-24-21(19)26-14-27-22)20-7-6-18(12-25-20)33(31,32)28-16-4-2-15(23)3-5-16/h2-8,10,12,14,17,28H,9,11,13H2,1H3,(H,24,26,27)/t17-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...


US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM228707
PNG
(US9346810, 254)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)S(=O)(=O)NCc1ccc(F)cc1
Show InChI InChI=1S/C23H24FN7O2S/c1-30(18-9-11-31(14-18)23-20-8-10-25-22(20)27-15-28-23)21-7-6-19(13-26-21)34(32,33)29-12-16-2-4-17(24)5-3-16/h2-8,10,13,15,18,29H,9,11-12,14H2,1H3,(H,25,27,28)/t18-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...


US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM228708
PNG
(US9346810, 259)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)S(=O)(=O)NC1CCOCC1
Show InChI InChI=1S/C21H27N7O3S/c1-27(16-5-9-28(13-16)21-18-4-8-22-20(18)24-14-25-21)19-3-2-17(12-23-19)32(29,30)26-15-6-10-31-11-7-15/h2-4,8,12,14-16,26H,5-7,9-11,13H2,1H3,(H,22,24,25)/t16-/m1/s1
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n/an/a 0.0550n/an/an/an/an/a25



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...


US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM228645
PNG
(US10111875, Compound 47 | US9346810, 47)
Show SMILES CNS(=O)(=O)N(C)[C@@H]1CCN(C1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C12H18N6O2S/c1-13-21(19,20)17(2)9-4-6-18(7-9)12-10-3-5-14-11(10)15-8-16-12/h3,5,8-9,13H,4,6-7H2,1-2H3,(H,14,15,16)/t9-/m1/s1
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n/an/a 119n/an/an/an/an/a25



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...


US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM228644
PNG
(US10111875, Compound 105 | US9346810, 105)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C18H17FN6/c1-24(13-3-2-12(9-20)16(19)8-13)14-5-7-25(10-14)18-15-4-6-21-17(15)22-11-23-18/h2-4,6,8,11,14H,5,7,10H2,1H3,(H,21,22,23)/t14-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...


US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM228643
PNG
(US9346810, 142)
Show SMILES CN([C@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ncc(cn1)C#N
Show InChI InChI=1S/C16H16N8/c1-23(16-19-7-11(6-17)8-20-16)12-3-5-24(9-12)15-13-2-4-18-14(13)21-10-22-15/h2,4,7-8,10,12H,3,5,9H2,1H3,(H,18,21,22)/t12-/m0/s1
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n/an/a 9.40n/an/an/an/an/a25



HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...


US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM228641
PNG
(US9346810, 199)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)C(=O)Nc1nccs1
Show InChI InChI=1S/C20H20N8OS/c1-27(16-3-2-13(10-23-16)19(29)26-20-22-7-9-30-20)14-5-8-28(11-14)18-15-4-6-21-17(15)24-12-25-18/h2-4,6-7,9-10,12,14H,5,8,11H2,1H3,(H,21,24,25)(H,22,26,29)/t14-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...


US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM228642
PNG
(US9346810, 206)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cc1F)C(=O)NC1[C@H](O)Cc2ccccc12
Show InChI InChI=1S/C27H27FN6O2/c1-33(18-9-11-34(14-18)26-20-8-10-29-25(20)30-15-31-26)22-7-6-17(12-21(22)28)27(36)32-24-19-5-3-2-4-16(19)13-23(24)35/h2-8,10,12,15,18,23-24,35H,9,11,13-14H2,1H3,(H,32,36)(H,29,30,31)/t18-,23-,24?/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...


US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM228640
PNG
(US10111875, Compound 234 | US9346810, 234)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)c1ccc(cn1)S(N)(=O)=O
Show InChI InChI=1S/C16H19N7O2S/c1-22(14-3-2-12(8-19-14)26(17,24)25)11-5-7-23(9-11)16-13-4-6-18-15(13)20-10-21-16/h2-4,6,8,10-11H,5,7,9H2,1H3,(H2,17,24,25)(H,18,20,21)/t11-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...


US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM228661
PNG
(US9346810, 1)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)C(=O)CC#N
Show InChI InChI=1S/C14H16N6O/c1-19(12(21)2-5-15)10-4-7-20(8-10)14-11-3-6-16-13(11)17-9-18-14/h3,6,9-10H,2,4,7-8H2,1H3,(H,16,17,18)/t10-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...


US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM228662
PNG
(US9346810, 16)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)C(=O)Nc1cccc(c1)C#N
Show InChI InChI=1S/C19H19N7O/c1-25(19(27)24-14-4-2-3-13(9-14)10-20)15-6-8-26(11-15)18-16-5-7-21-17(16)22-12-23-18/h2-5,7,9,12,15H,6,8,11H2,1H3,(H,24,27)(H,21,22,23)/t15-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

US Patent


Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...


US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
JAK1 (aa866-1154)


(Homo sapiens (Human))
BDBM228663
PNG
(US9346810, 21)
Show SMILES CN([C@@H]1CCN(C1)c1ncnc2[nH]ccc12)C(=O)CCc1c(Cl)cccc1Cl
Show InChI InChI=1S/C20H21Cl2N5O/c1-26(18(28)6-5-14-16(21)3-2-4-17(14)22)13-8-10-27(11-13)20-15-7-9-23-19(15)24-12-25-20/h2-4,7,9,12-13H,5-6,8,10-11H2,1H3,(H,23,24,25)/t13-/m1/s1
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HUTCHISON MEDIPHARMA LIMITED

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Assay Description
JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...


US Patent US9346810 (2016)


BindingDB Entry DOI: 10.7270/Q2XG9Q0X
More data for this
Ligand-Target Pair
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