BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 3232 hits Enz. Inhib. hit(s) with Target = 'Lck'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
SRC


(Homo sapiens (human))
BDBM13224
PNG
(2-N-benzene-4-methyl-5-N-(2,4,6-trimethylphenyl)-1...)
Show SMILES Cc1nc(NC(=O)c2ccccc2)sc1C(=O)Nc1c(C)cc(C)cc1C
Show InChI InChI=1S/C21H21N3O2S/c1-12-10-13(2)17(14(3)11-12)23-20(26)18-15(4)22-21(27-18)24-19(25)16-8-6-5-7-9-16/h5-11H,1-4H3,(H,23,26)(H,22,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 800n/an/an/an/a7.022



Bristol-Myers Squibb Company



Assay Description
IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...


J Med Chem 49: 6819-32 (2006)


Article DOI: 10.1021/jm060727j
BindingDB Entry DOI: 10.7270/Q2QN6501
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM13223
PNG
(2-acetamido-4-methyl-N-(2,4,6-trimethylphenyl)-1,3...)
Show SMILES CC(=O)Nc1nc(C)c(s1)C(=O)Nc1c(C)cc(C)cc1C
Show InChI InChI=1S/C16H19N3O2S/c1-8-6-9(2)13(10(3)7-8)19-15(21)14-11(4)17-16(22-14)18-12(5)20/h6-7H,1-5H3,(H,19,21)(H,17,18,20)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 480n/an/an/an/a7.022



Bristol-Myers Squibb Company



Assay Description
IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...


J Med Chem 49: 6819-32 (2006)


Article DOI: 10.1021/jm060727j
BindingDB Entry DOI: 10.7270/Q2QN6501
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM6619
PNG
(3-[(9bR)-5-oxo-1H,2H,3H,5H,9bH-benzo[a]pyrrolizin-...)
Show SMILES O=C(Nc1ccccn1)Nc1cccc2C(=O)N3CCC[C@@H]3c12
Show InChI InChI=1S/C17H16N4O2/c22-16-11-5-3-6-12(15(11)13-7-4-10-21(13)16)19-17(23)20-14-8-1-2-9-18-14/h1-3,5-6,8-9,13H,4,7,10H2,(H2,18,19,20,23)/t13-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/a 2.30E+3n/an/an/an/a7.022



Banyu Tsukuba Research Institute



Assay Description
Src, Lck, Flt-1, ZAP, EGFR, FGFR1, and PFGFR-beta were assayed in the Merck research laboratory (Homogeneous proximity tyrosine kinase assays: scinti...


J Med Chem 44: 4628-40 (2001)


Article DOI: 10.1021/jm010326y
BindingDB Entry DOI: 10.7270/Q2BV7DS8
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM13222
PNG
(2-[[(Methoxy)carbonyl]-amino]-4-methyl-N-(2,4,6-tr...)
Show SMILES COC(=O)Nc1nc(C)c(s1)C(=O)Nc1c(C)cc(C)cc1C
Show InChI InChI=1S/C16H19N3O3S/c1-8-6-9(2)12(10(3)7-8)18-14(20)13-11(4)17-15(23-13)19-16(21)22-5/h6-7H,1-5H3,(H,18,20)(H,17,19,21)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 700n/an/an/an/a7.022



Bristol-Myers Squibb Company



Assay Description
IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...


J Med Chem 49: 6819-32 (2006)


Article DOI: 10.1021/jm060727j
BindingDB Entry DOI: 10.7270/Q2QN6501
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM13221
PNG
(BMS-354825 tert-Butoxycarbamate Analog 5e | CHEMBL...)
Show SMILES Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)Nc1c(Cl)cccc1Cl
Show InChI InChI=1S/C16H17Cl2N3O3S/c1-8-12(13(22)20-11-9(17)6-5-7-10(11)18)25-14(19-8)21-15(23)24-16(2,3)4/h5-7H,1-4H3,(H,20,22)(H,19,21,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.25E+4n/an/an/an/a7.022



Bristol-Myers Squibb Company



Assay Description
IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...


J Med Chem 49: 6819-32 (2006)


Article DOI: 10.1021/jm060727j
BindingDB Entry DOI: 10.7270/Q2QN6501
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM13215
PNG
(2-Aminothiazole 1 | 2-amino-4-methyl-N-(2,4,6-trim...)
Show SMILES Cc1nc(N)sc1C(=O)Nc1c(C)cc(C)cc1C
Show InChI InChI=1S/C14H17N3OS/c1-7-5-8(2)11(9(3)6-7)17-13(18)12-10(4)16-14(15)19-12/h5-6H,1-4H3,(H2,15,16)(H,17,18)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 5.00E+3n/an/an/an/a7.022



Bristol-Myers Squibb Company



Assay Description
IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...


J Med Chem 49: 6819-32 (2006)


Article DOI: 10.1021/jm060727j
BindingDB Entry DOI: 10.7270/Q2QN6501
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM13219
PNG
(2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(2,...)
Show SMILES Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)Nc1c(C)cccc1C
Show InChI InChI=1S/C18H23N3O3S/c1-10-8-7-9-11(2)13(10)20-15(22)14-12(3)19-16(25-14)21-17(23)24-18(4,5)6/h7-9H,1-6H3,(H,20,22)(H,19,21,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 4.40E+3n/an/an/an/a7.022



Bristol-Myers Squibb Company



Assay Description
IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...


J Med Chem 49: 6819-32 (2006)


Article DOI: 10.1021/jm060727j
BindingDB Entry DOI: 10.7270/Q2QN6501
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM13218
PNG
(2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(2-...)
Show SMILES Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)Nc1c(C)cccc1Cl
Show InChI InChI=1S/C17H20ClN3O3S/c1-9-7-6-8-11(18)12(9)20-14(22)13-10(2)19-15(25-13)21-16(23)24-17(3,4)5/h6-8H,1-5H3,(H,20,22)(H,19,21,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.80E+4n/an/an/an/a7.022



Bristol-Myers Squibb Company



Assay Description
IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...


J Med Chem 49: 6819-32 (2006)


Article DOI: 10.1021/jm060727j
BindingDB Entry DOI: 10.7270/Q2QN6501
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM13217
PNG
(2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(2,...)
Show SMILES Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)Nc1c(C)cc(C)cc1C
Show InChI InChI=1S/C19H25N3O3S/c1-10-8-11(2)14(12(3)9-10)21-16(23)15-13(4)20-17(26-15)22-18(24)25-19(5,6)7/h8-9H,1-7H3,(H,21,23)(H,20,22,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.50E+3n/an/an/an/a7.022



Bristol-Myers Squibb Company



Assay Description
IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...


J Med Chem 49: 6819-32 (2006)


Article DOI: 10.1021/jm060727j
BindingDB Entry DOI: 10.7270/Q2QN6501
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM13216
PNG
(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Show SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1
Show InChI InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

DrugBank
Article
PubMed
n/an/a 0.400n/an/an/an/a7.022



Bristol-Myers Squibb Company



Assay Description
IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...


J Med Chem 49: 6819-32 (2006)


Article DOI: 10.1021/jm060727j
BindingDB Entry DOI: 10.7270/Q2QN6501
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM13220
PNG
(2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(4-...)
Show SMILES Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)Nc1c(C)cc(Br)cc1C
Show InChI InChI=1S/C18H22BrN3O3S/c1-9-7-12(19)8-10(2)13(9)21-15(23)14-11(3)20-16(26-14)22-17(24)25-18(4,5)6/h7-8H,1-6H3,(H,21,23)(H,20,22,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.40E+3n/an/an/an/a7.022



Bristol-Myers Squibb Company



Assay Description
IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...


J Med Chem 49: 6819-32 (2006)


Article DOI: 10.1021/jm060727j
BindingDB Entry DOI: 10.7270/Q2QN6501
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM1773
PNG
(US8476284, 4 | US8497277, 13 | US8497277, 4 | US91...)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H24N6O2/c1-2-21(32)30-14-6-7-18(15-30)31-25-22(24(26)27-16-28-25)23(29-31)17-10-12-20(13-11-17)33-19-8-4-3-5-9-19/h2-5,8-13,16,18H,1,6-7,14-15H2,(H2,26,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
PDB
UniChem

Similars

14n/an/an/an/an/an/a7.4n/a



Pharmacyclics, Inc.

US Patent


Assay Description
Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.


US Patent US8476284 (2013)


BindingDB Entry DOI: 10.7270/Q2CJ8C3G
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM1773
PNG
(US8476284, 4 | US8497277, 13 | US8497277, 4 | US91...)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H24N6O2/c1-2-21(32)30-14-6-7-18(15-30)31-25-22(24(26)27-16-28-25)23(29-31)17-10-12-20(13-11-17)33-19-8-4-3-5-9-19/h2-5,8-13,16,18H,1,6-7,14-15H2,(H2,26,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
PDB
UniChem

Similars

97n/an/an/an/an/an/a7.4n/a



Pharmacyclics, Inc.

US Patent


Assay Description
Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.


US Patent US8476284 (2013)


BindingDB Entry DOI: 10.7270/Q2CJ8C3G
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM8801
PNG
(Pyrazolo[3,4-d]pyrimidine 9 | [(4-{4-amino-1-[4-(4...)
Show SMILES COc1cc(ccc1NS(=O)(=O)Nc1ccccc1)-c1nn([C@H]2CC[C@@H](CC2)N2CCN(C)CC2)c2ncnc(N)c12
Show InChI InChI=1S/C29H37N9O3S/c1-36-14-16-37(17-15-36)22-9-11-23(12-10-22)38-29-26(28(30)31-19-32-29)27(33-38)20-8-13-24(25(18-20)41-2)35-42(39,40)34-21-6-4-3-5-7-21/h3-8,13,18-19,22-23,34-35H,9-12,14-17H2,1-2H3,(H2,30,31,32)/t22-,23-
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 167n/an/an/an/a7.422



Abbott Bioresearch Center



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 12: 1687-90 (2002)


Article DOI: 10.1016/s0960-894x(02)00196-8
BindingDB Entry DOI: 10.7270/Q2154F84
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM8804
PNG
(N-(4-{4-amino-1-[4-(4-methylpiperazin-1-yl)cyclohe...)
Show SMILES COc1cc(ccc1NC(=O)C(C)(C)Cc1ccccc1)-c1nn([C@H]2CC[C@@H](CC2)N2CCN(C)CC2)c2ncnc(N)c12
Show InChI InChI=1S/C34H44N8O2/c1-34(2,21-23-8-6-5-7-9-23)33(43)38-27-15-10-24(20-28(27)44-4)30-29-31(35)36-22-37-32(29)42(39-30)26-13-11-25(12-14-26)41-18-16-40(3)17-19-41/h5-10,15,20,22,25-26H,11-14,16-19,21H2,1-4H3,(H,38,43)(H2,35,36,37)/t25-,26-
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 92n/an/an/an/a7.422



Abbott Bioresearch Center



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 12: 1687-90 (2002)


Article DOI: 10.1016/s0960-894x(02)00196-8
BindingDB Entry DOI: 10.7270/Q2154F84
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM8805
PNG
(N-(4-{4-amino-1-[4-(4-methylpiperazin-1-yl)cyclohe...)
Show SMILES COc1cc(ccc1NC(=O)CC(C)(C)c1ccccc1)-c1nn([C@H]2CC[C@@H](CC2)N2CCN(C)CC2)c2ncnc(N)c12
Show InChI InChI=1S/C34H44N8O2/c1-34(2,24-8-6-5-7-9-24)21-29(43)38-27-15-10-23(20-28(27)44-4)31-30-32(35)36-22-37-33(30)42(39-31)26-13-11-25(12-14-26)41-18-16-40(3)17-19-41/h5-10,15,20,22,25-26H,11-14,16-19,21H2,1-4H3,(H,38,43)(H2,35,36,37)/t25-,26-
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 31n/an/an/an/a7.422



Abbott Bioresearch Center



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 12: 1687-90 (2002)


Article DOI: 10.1016/s0960-894x(02)00196-8
BindingDB Entry DOI: 10.7270/Q2154F84
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM8806
PNG
((1R,2R)-N-(4-{4-amino-1-[4-(4-methylpiperazin-1-yl...)
Show SMILES COc1cc(ccc1NC(=O)[C@@H]1C[C@H]1c1ccccc1)-c1nn([C@H]2CC[C@@H](CC2)N2CCN(C)CC2)c2ncnc(N)c12
Show InChI InChI=1S/C33H40N8O2/c1-39-14-16-40(17-15-39)23-9-11-24(12-10-23)41-32-29(31(34)35-20-36-32)30(38-41)22-8-13-27(28(18-22)43-2)37-33(42)26-19-25(26)21-6-4-3-5-7-21/h3-8,13,18,20,23-26H,9-12,14-17,19H2,1-2H3,(H,37,42)(H2,34,35,36)/t23-,24-,25-,26+/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 19n/an/an/an/a7.422



Abbott Bioresearch Center



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 12: 1687-90 (2002)


Article DOI: 10.1016/s0960-894x(02)00196-8
BindingDB Entry DOI: 10.7270/Q2154F84
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM8807
PNG
(CHEMBL43773 | N-(4-{4-amino-1-[4-(4-methylpiperazi...)
Show SMILES COc1cc(ccc1NC(=O)c1cc2ccccc2o1)-c1nn([C@H]2CC[C@@H](CC2)N2CCN(C)CC2)c2ncnc(N)c12
Show InChI InChI=1S/C32H36N8O3/c1-38-13-15-39(16-14-38)22-8-10-23(11-9-22)40-31-28(30(33)34-19-35-31)29(37-40)21-7-12-24(26(18-21)42-2)36-32(41)27-17-20-5-3-4-6-25(20)43-27/h3-7,12,17-19,22-23H,8-11,13-16H2,1-2H3,(H,36,41)(H2,33,34,35)/t22-,23-
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 10n/an/an/an/a7.422



Abbott Bioresearch Center



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 12: 1687-90 (2002)


Article DOI: 10.1016/s0960-894x(02)00196-8
BindingDB Entry DOI: 10.7270/Q2154F84
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM8808
PNG
(3-{4-[(1H-indol-2-ylmethyl)amino]phenyl}-1-[4-(4-m...)
Show SMILES CN1CCN(CC1)[C@H]1CC[C@@H](CC1)n1nc(-c2ccc(NCc3cc4ccccc4[nH]3)cc2)c2c(N)ncnc12
Show InChI InChI=1S/C31H37N9/c1-38-14-16-39(17-15-38)25-10-12-26(13-11-25)40-31-28(30(32)34-20-35-31)29(37-40)21-6-8-23(9-7-21)33-19-24-18-22-4-2-3-5-27(22)36-24/h2-9,18,20,25-26,33,36H,10-17,19H2,1H3,(H2,32,34,35)/t25-,26-
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 50n/an/an/an/a7.422



Abbott Bioresearch Center



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 12: 1687-90 (2002)


Article DOI: 10.1016/s0960-894x(02)00196-8
BindingDB Entry DOI: 10.7270/Q2154F84
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM8800
PNG
(N-(4-{4-amino-1-[4-(4-methylpiperazin-1-yl)cyclohe...)
Show SMILES COc1cc(ccc1NS(=O)(=O)c1ccccc1)-c1nn([C@H]2CC[C@@H](CC2)N2CCN(C)CC2)c2ncnc(N)c12
Show InChI InChI=1S/C29H36N8O3S/c1-35-14-16-36(17-15-35)21-9-11-22(12-10-21)37-29-26(28(30)31-19-32-29)27(33-37)20-8-13-24(25(18-20)40-2)34-41(38,39)23-6-4-3-5-7-23/h3-8,13,18-19,21-22,34H,9-12,14-17H2,1-2H3,(H2,30,31,32)/t21-,22-
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.12E+3n/an/an/an/a7.422



Abbott Bioresearch Center



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 12: 1687-90 (2002)


Article DOI: 10.1016/s0960-894x(02)00196-8
BindingDB Entry DOI: 10.7270/Q2154F84
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM8799
PNG
(3-(4-{4-amino-1-[4-(4-methylpiperazin-1-yl)cyclohe...)
Show SMILES COc1cc(ccc1NC(=O)Nc1ccccc1)-c1nn([C@H]2CC[C@@H](CC2)N2CCN(C)CC2)c2ncnc(N)c12
Show InChI InChI=1S/C30H37N9O2/c1-37-14-16-38(17-15-37)22-9-11-23(12-10-22)39-29-26(28(31)32-19-33-29)27(36-39)20-8-13-24(25(18-20)41-2)35-30(40)34-21-6-4-3-5-7-21/h3-8,13,18-19,22-23H,9-12,14-17H2,1-2H3,(H2,31,32,33)(H2,34,35,40)/t22-,23-
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 209n/an/an/an/a7.422



Abbott Bioresearch Center



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 12: 1687-90 (2002)


Article DOI: 10.1016/s0960-894x(02)00196-8
BindingDB Entry DOI: 10.7270/Q2154F84
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM8798
PNG
(CHEMBL47787 | Pyrazolo[3,4-d]pyrimidine 6 | benzyl...)
Show SMILES COc1cc(ccc1NC(=O)OCc1ccccc1)-c1nn([C@H]2CC[C@@H](CC2)N2CCN(C)CC2)c2ncnc(N)c12
Show InChI InChI=1S/C31H38N8O3/c1-37-14-16-38(17-15-37)23-9-11-24(12-10-23)39-30-27(29(32)33-20-34-30)28(36-39)22-8-13-25(26(18-22)41-2)35-31(40)42-19-21-6-4-3-5-7-21/h3-8,13,18,20,23-24H,9-12,14-17,19H2,1-2H3,(H,35,40)(H2,32,33,34)/t23-,24-
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4n/an/an/an/a7.422



Abbott Bioresearch Center



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 12: 1687-90 (2002)


Article DOI: 10.1016/s0960-894x(02)00196-8
BindingDB Entry DOI: 10.7270/Q2154F84
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM8797
PNG
(CHEMBL297363 | N-(4-{4-amino-1-[4-(4-methylpiperaz...)
Show SMILES COc1cc(ccc1NC(=O)c1ccccc1)-c1nn([C@H]2CC[C@@H](CC2)N2CCN(C)CC2)c2ncnc(N)c12
Show InChI InChI=1S/C30H36N8O2/c1-36-14-16-37(17-15-36)22-9-11-23(12-10-22)38-29-26(28(31)32-19-33-29)27(35-38)21-8-13-24(25(18-21)40-2)34-30(39)20-6-4-3-5-7-20/h3-8,13,18-19,22-23H,9-12,14-17H2,1-2H3,(H,34,39)(H2,31,32,33)/t22-,23-
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 93n/an/an/an/a7.422



Abbott Bioresearch Center



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 12: 1687-90 (2002)


Article DOI: 10.1016/s0960-894x(02)00196-8
BindingDB Entry DOI: 10.7270/Q2154F84
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM8796
PNG
(3-(4-benzoylphenyl)-1-[4-(4-methylpiperazin-1-yl)c...)
Show SMILES CN1CCN(CC1)[C@H]1CC[C@@H](CC1)n1nc(-c2ccc(cc2)C(=O)c2ccccc2)c2c(N)ncnc12
Show InChI InChI=1S/C29H33N7O/c1-34-15-17-35(18-16-34)23-11-13-24(14-12-23)36-29-25(28(30)31-19-32-29)26(33-36)20-7-9-22(10-8-20)27(37)21-5-3-2-4-6-21/h2-10,19,23-24H,11-18H2,1H3,(H2,30,31,32)/t23-,24-
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 110n/an/an/an/a7.422



Abbott Bioresearch Center



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 12: 1687-90 (2002)


Article DOI: 10.1016/s0960-894x(02)00196-8
BindingDB Entry DOI: 10.7270/Q2154F84
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM8795
PNG
(1-[4-(4-methylpiperazin-1-yl)cyclohexyl]-3-[4-(phe...)
Show SMILES CN1CCN(CC1)[C@H]1CC[C@@H](CC1)n1nc(-c2ccc(Nc3ccccc3)cc2)c2c(N)ncnc12
Show InChI InChI=1S/C28H34N8/c1-34-15-17-35(18-16-34)23-11-13-24(14-12-23)36-28-25(27(29)30-19-31-28)26(33-36)20-7-9-22(10-8-20)32-21-5-3-2-4-6-21/h2-10,19,23-24,32H,11-18H2,1H3,(H2,29,30,31)/t23-,24-
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 40n/an/an/an/a7.422



Abbott Bioresearch Center



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 12: 1687-90 (2002)


Article DOI: 10.1016/s0960-894x(02)00196-8
BindingDB Entry DOI: 10.7270/Q2154F84
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM8794
PNG
(1-[4-(4-methylpiperazin-1-yl)cyclohexyl]-3-(4-phen...)
Show SMILES CN1CCN(CC1)[C@H]1CC[C@@H](CC1)n1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc12
Show InChI InChI=1S/C28H33N7O/c1-33-15-17-34(18-16-33)21-9-11-22(12-10-21)35-28-25(27(29)30-19-31-28)26(32-35)20-7-13-24(14-8-20)36-23-5-3-2-4-6-23/h2-8,13-14,19,21-22H,9-12,15-18H2,1H3,(H2,29,30,31)/t21-,22-
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 40n/an/an/an/a7.422



Abbott Bioresearch Center



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 12: 1687-90 (2002)


Article DOI: 10.1016/s0960-894x(02)00196-8
BindingDB Entry DOI: 10.7270/Q2154F84
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM8793
PNG
(7-[4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phen...)
Show SMILES CN1CCN(CC1)[C@H]1CC[C@@H](CC1)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc12
Show InChI InChI=1S/C29H34N6O/c1-33-15-17-34(18-16-33)22-9-11-23(12-10-22)35-19-26(27-28(30)31-20-32-29(27)35)21-7-13-25(14-8-21)36-24-5-3-2-4-6-24/h2-8,13-14,19-20,22-23H,9-12,15-18H2,1H3,(H2,30,31,32)/t22-,23-
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 15n/an/an/an/a7.422



Abbott Bioresearch Center



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 12: 1687-90 (2002)


Article DOI: 10.1016/s0960-894x(02)00196-8
BindingDB Entry DOI: 10.7270/Q2154F84
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM8802
PNG
(3-[4-(benzylamino)-3-methoxyphenyl]-1-[4-(4-methyl...)
Show SMILES COc1cc(ccc1NCc1ccccc1)-c1nn([C@H]2CC[C@@H](CC2)N2CCN(C)CC2)c2ncnc(N)c12
Show InChI InChI=1S/C30H38N8O/c1-36-14-16-37(17-15-36)23-9-11-24(12-10-23)38-30-27(29(31)33-20-34-30)28(35-38)22-8-13-25(26(18-22)39-2)32-19-21-6-4-3-5-7-21/h3-8,13,18,20,23-24,32H,9-12,14-17,19H2,1-2H3,(H2,31,33,34)/t23-,24-
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 55n/an/an/an/a7.422



Abbott Bioresearch Center



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 12: 1687-90 (2002)


Article DOI: 10.1016/s0960-894x(02)00196-8
BindingDB Entry DOI: 10.7270/Q2154F84
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM8803
PNG
(CHEMBL295601 | N-(4-{4-amino-1-[4-(4-methylpiperaz...)
Show SMILES COc1cc(ccc1NC(=O)CCc1ccccc1)-c1nn([C@H]2CC[C@@H](CC2)N2CCN(C)CC2)c2ncnc(N)c12
Show InChI InChI=1S/C32H40N8O2/c1-38-16-18-39(19-17-38)24-10-12-25(13-11-24)40-32-29(31(33)34-21-35-32)30(37-40)23-9-14-26(27(20-23)42-2)36-28(41)15-8-22-6-4-3-5-7-22/h3-7,9,14,20-21,24-25H,8,10-13,15-19H2,1-2H3,(H,36,41)(H2,33,34,35)/t24-,25-
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 28n/an/an/an/a7.422



Abbott Bioresearch Center



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 12: 1687-90 (2002)


Article DOI: 10.1016/s0960-894x(02)00196-8
BindingDB Entry DOI: 10.7270/Q2154F84
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM13534
PNG
(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Show SMILES CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1
Show InChI InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
80 -40.1n/an/an/an/an/a7.522



Vertex Pharmaceuticals (Europe) Limited



Assay Description
The kinase activity was determined by incubation of enzyme and its substrate, and test compound, in the presence ATP/[gamma-32P] ATP. After incubatio...


Nat Med 10: 262-7 (2004)


Article DOI: 10.1038/nm1003
BindingDB Entry DOI: 10.7270/Q25M63ZF
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM26367
PNG
(Aminoquinazoline amide, 35 | N-[3-(2-aminoquinazol...)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1ccc2nc(N)ncc2c1
Show InChI InChI=1S/C23H17F3N4O/c1-13-5-7-18(29-21(31)15-3-2-4-17(10-15)23(24,25)26)11-19(13)14-6-8-20-16(9-14)12-28-22(27)30-20/h2-12H,1H3,(H,29,31)(H2,27,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 0.400n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...


J Med Chem 51: 1681-94 (2008)


Article DOI: 10.1021/jm7010996
BindingDB Entry DOI: 10.7270/Q2Q81BCB
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM26368
PNG
(3-N-(2-aminopyrimidin-5-yl)-4-methyl-1-N-[3-(trifl...)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1C(=O)Nc1cnc(N)nc1
Show InChI InChI=1S/C20H16F3N5O2/c1-11-5-6-14(8-16(11)18(30)28-15-9-25-19(24)26-10-15)27-17(29)12-3-2-4-13(7-12)20(21,22)23/h2-10H,1H3,(H,27,29)(H,28,30)(H2,24,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 14n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...


J Med Chem 51: 1681-94 (2008)


Article DOI: 10.1021/jm7010996
BindingDB Entry DOI: 10.7270/Q2Q81BCB
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM26369
PNG
(4-methyl-3-N-(2-{[4-(4-methylpiperazin-1-yl)phenyl...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4cccc(c4)C(F)(F)F)ccc3C)cn2)cc1
Show InChI InChI=1S/C31H30F3N7O2/c1-20-6-7-24(37-28(42)21-4-3-5-22(16-21)31(32,33)34)17-27(20)29(43)38-25-18-35-30(36-19-25)39-23-8-10-26(11-9-23)41-14-12-40(2)13-15-41/h3-11,16-19H,12-15H2,1-2H3,(H,37,42)(H,38,43)(H,35,36,39)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 0.600n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...


J Med Chem 51: 1681-94 (2008)


Article DOI: 10.1021/jm7010996
BindingDB Entry DOI: 10.7270/Q2Q81BCB
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM26370
PNG
(3-[3-(2-aminoquinazolin-6-yl)-4-methylphenyl]-1-[3...)
Show SMILES Cc1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1-c1ccc2nc(N)ncc2c1
Show InChI InChI=1S/C23H18F3N5O/c1-13-5-7-18(30-22(32)29-17-4-2-3-16(10-17)23(24,25)26)11-19(13)14-6-8-20-15(9-14)12-28-21(27)31-20/h2-12H,1H3,(H2,27,28,31)(H2,29,30,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 7n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...


J Med Chem 51: 1681-94 (2008)


Article DOI: 10.1021/jm7010996
BindingDB Entry DOI: 10.7270/Q2Q81BCB
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM26371
PNG
(Aminopyrimidine amide urea, 23a | N-(2-aminopyrimi...)
Show SMILES Cc1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1C(=O)Nc1cnc(N)nc1
Show InChI InChI=1S/C20H17F3N6O2/c1-11-5-6-14(8-16(11)17(30)27-15-9-25-18(24)26-10-15)29-19(31)28-13-4-2-3-12(7-13)20(21,22)23/h2-10H,1H3,(H,27,30)(H2,24,25,26)(H2,28,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 63n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...


J Med Chem 51: 1681-94 (2008)


Article DOI: 10.1021/jm7010996
BindingDB Entry DOI: 10.7270/Q2Q81BCB
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM26372
PNG
(2-methyl-N-(2-{[4-(4-methylpiperazin-1-yl)phenyl]a...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(NC(=O)c3cc(NC(=O)Nc4cccc(c4)C(F)(F)F)ccc3C)cn2)cc1
Show InChI InChI=1S/C31H31F3N8O2/c1-20-6-7-24(40-30(44)39-23-5-3-4-21(16-23)31(32,33)34)17-27(20)28(43)37-25-18-35-29(36-19-25)38-22-8-10-26(11-9-22)42-14-12-41(2)13-15-42/h3-11,16-19H,12-15H2,1-2H3,(H,37,43)(H,35,36,38)(H2,39,40,44)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 0.600n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...


J Med Chem 51: 1681-94 (2008)


Article DOI: 10.1021/jm7010996
BindingDB Entry DOI: 10.7270/Q2Q81BCB
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM26373
PNG
(4-methyl-3-N-(pyrimidin-5-yl)-1-N-[3-(trifluoromet...)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1C(=O)Nc1cncnc1
Show InChI InChI=1S/C20H15F3N4O2/c1-12-5-6-15(8-17(12)19(29)27-16-9-24-11-25-10-16)26-18(28)13-3-2-4-14(7-13)20(21,22)23/h2-11H,1H3,(H,26,28)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 239n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...


J Med Chem 51: 1681-94 (2008)


Article DOI: 10.1021/jm7010996
BindingDB Entry DOI: 10.7270/Q2Q81BCB
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM26374
PNG
(4-methyl-3-N-(2-{[3-(morpholin-4-yl)propyl]amino}p...)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1C(=O)Nc1cnc(NCCCN2CCOCC2)nc1
Show InChI InChI=1S/C27H29F3N6O3/c1-18-6-7-21(34-24(37)19-4-2-5-20(14-19)27(28,29)30)15-23(18)25(38)35-22-16-32-26(33-17-22)31-8-3-9-36-10-12-39-13-11-36/h2,4-7,14-17H,3,8-13H2,1H3,(H,34,37)(H,35,38)(H,31,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 24n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...


J Med Chem 51: 1681-94 (2008)


Article DOI: 10.1021/jm7010996
BindingDB Entry DOI: 10.7270/Q2Q81BCB
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM26375
PNG
(4-methyl-3-N-(2-{[2-(morpholin-4-yl)ethyl]amino}py...)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1C(=O)Nc1cnc(NCCN2CCOCC2)nc1
Show InChI InChI=1S/C26H27F3N6O3/c1-17-5-6-20(33-23(36)18-3-2-4-19(13-18)26(27,28)29)14-22(17)24(37)34-21-15-31-25(32-16-21)30-7-8-35-9-11-38-12-10-35/h2-6,13-16H,7-12H2,1H3,(H,33,36)(H,34,37)(H,30,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 72n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...


J Med Chem 51: 1681-94 (2008)


Article DOI: 10.1021/jm7010996
BindingDB Entry DOI: 10.7270/Q2Q81BCB
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM26376
PNG
(4-methyl-3-N-{2-[(1-methylpiperidin-4-yl)amino]pyr...)
Show SMILES CN1CCC(CC1)Nc1ncc(NC(=O)c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)cn1
Show InChI InChI=1S/C26H27F3N6O2/c1-16-6-7-20(32-23(36)17-4-3-5-18(12-17)26(27,28)29)13-22(16)24(37)33-21-14-30-25(31-15-21)34-19-8-10-35(2)11-9-19/h3-7,12-15,19H,8-11H2,1-2H3,(H,32,36)(H,33,37)(H,30,31,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.31E+3n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...


J Med Chem 51: 1681-94 (2008)


Article DOI: 10.1021/jm7010996
BindingDB Entry DOI: 10.7270/Q2Q81BCB
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM26377
PNG
(5-acetamido-2-methyl-N-(2-{[4-(4-methylpiperazin-1...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(NC(=O)c3cc(NC(C)=O)ccc3C)cn2)cc1
Show InChI InChI=1S/C25H29N7O2/c1-17-4-5-20(28-18(2)33)14-23(17)24(34)29-21-15-26-25(27-16-21)30-19-6-8-22(9-7-19)32-12-10-31(3)11-13-32/h4-9,14-16H,10-13H2,1-3H3,(H,28,33)(H,29,34)(H,26,27,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 48n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...


J Med Chem 51: 1681-94 (2008)


Article DOI: 10.1021/jm7010996
BindingDB Entry DOI: 10.7270/Q2Q81BCB
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM26378
PNG
(5-methyl-N-{4-methyl-3-[(2-{[4-(4-methylpiperazin-...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4cnoc4C)ccc3C)cn2)cc1
Show InChI InChI=1S/C28H30N8O3/c1-18-4-5-21(32-27(38)25-17-31-39-19(25)2)14-24(18)26(37)33-22-15-29-28(30-16-22)34-20-6-8-23(9-7-20)36-12-10-35(3)11-13-36/h4-9,14-17H,10-13H2,1-3H3,(H,32,38)(H,33,37)(H,29,30,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 14n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...


J Med Chem 51: 1681-94 (2008)


Article DOI: 10.1021/jm7010996
BindingDB Entry DOI: 10.7270/Q2Q81BCB
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM26379
PNG
(1-N-benzene-4-methyl-3-N-(2-{[4-(4-methylpiperazin...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4ccccc4)ccc3C)cn2)cc1
Show InChI InChI=1S/C30H31N7O2/c1-21-8-9-24(33-28(38)22-6-4-3-5-7-22)18-27(21)29(39)34-25-19-31-30(32-20-25)35-23-10-12-26(13-11-23)37-16-14-36(2)15-17-37/h3-13,18-20H,14-17H2,1-2H3,(H,33,38)(H,34,39)(H,31,32,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 5n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...


J Med Chem 51: 1681-94 (2008)


Article DOI: 10.1021/jm7010996
BindingDB Entry DOI: 10.7270/Q2Q81BCB
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM26380
PNG
(1-N-(2-methoxybenzene)-4-methyl-3-N-(2-{[4-(4-meth...)
Show SMILES COc1ccccc1C(=O)Nc1ccc(C)c(c1)C(=O)Nc1cnc(Nc2ccc(cc2)N2CCN(C)CC2)nc1
Show InChI InChI=1S/C31H33N7O3/c1-21-8-9-23(34-29(39)26-6-4-5-7-28(26)41-3)18-27(21)30(40)35-24-19-32-31(33-20-24)36-22-10-12-25(13-11-22)38-16-14-37(2)15-17-38/h4-13,18-20H,14-17H2,1-3H3,(H,34,39)(H,35,40)(H,32,33,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 5n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...


J Med Chem 51: 1681-94 (2008)


Article DOI: 10.1021/jm7010996
BindingDB Entry DOI: 10.7270/Q2Q81BCB
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM26381
PNG
(1-N-[3-fluoro-5-(trifluoromethyl)benzene]-4-methyl...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4cc(F)cc(c4)C(F)(F)F)ccc3C)cn2)cc1
Show InChI InChI=1S/C31H29F4N7O2/c1-19-3-4-24(38-28(43)20-13-21(31(33,34)35)15-22(32)14-20)16-27(19)29(44)39-25-17-36-30(37-18-25)40-23-5-7-26(8-6-23)42-11-9-41(2)10-12-42/h3-8,13-18H,9-12H2,1-2H3,(H,38,43)(H,39,44)(H,36,37,40)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 0.300n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...


J Med Chem 51: 1681-94 (2008)


Article DOI: 10.1021/jm7010996
BindingDB Entry DOI: 10.7270/Q2Q81BCB
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM26382
PNG
(4-methyl-1-N-[2-methyl-3-(trifluoromethyl)benzene]...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4cccc(c4C)C(F)(F)F)ccc3C)cn2)cc1
Show InChI InChI=1S/C32H32F3N7O2/c1-20-7-8-23(38-29(43)26-5-4-6-28(21(26)2)32(33,34)35)17-27(20)30(44)39-24-18-36-31(37-19-24)40-22-9-11-25(12-10-22)42-15-13-41(3)14-16-42/h4-12,17-19H,13-16H2,1-3H3,(H,38,43)(H,39,44)(H,36,37,40)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

PDB
Article
PubMed
n/an/a 0.800n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...


J Med Chem 51: 1681-94 (2008)


Article DOI: 10.1021/jm7010996
BindingDB Entry DOI: 10.7270/Q2Q81BCB
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SRC


(Homo sapiens (human))
BDBM26383
PNG
(2,2-difluoro-N-{4-methyl-3-[(2-{[4-(4-methylpipera...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4ccc5OC(F)(F)Oc5c4)ccc3C)cn2)cc1
Show InChI InChI=1S/C31H29F2N7O4/c1-19-3-5-22(36-28(41)20-4-10-26-27(15-20)44-31(32,33)43-26)16-25(19)29(42)37-23-17-34-30(35-18-23)38-21-6-8-24(9-7-21)40-13-11-39(2)12-14-40/h3-10,15-18H,11-14H2,1-2H3,(H,36,41)(H,37,42)(H,34,35,38)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.30n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...


J Med Chem 51: 1681-94 (2008)


Article DOI: 10.1021/jm7010996
BindingDB Entry DOI: 10.7270/Q2Q81BCB
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM26384
PNG
(1-N-(4-tert-butylbenzene)-4-methyl-3-N-(2-{[4-(4-m...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4ccc(cc4)C(C)(C)C)ccc3C)cn2)cc1
Show InChI InChI=1S/C34H39N7O2/c1-23-6-11-27(37-31(42)24-7-9-25(10-8-24)34(2,3)4)20-30(23)32(43)38-28-21-35-33(36-22-28)39-26-12-14-29(15-13-26)41-18-16-40(5)17-19-41/h6-15,20-22H,16-19H2,1-5H3,(H,37,42)(H,38,43)(H,35,36,39)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.5n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...


J Med Chem 51: 1681-94 (2008)


Article DOI: 10.1021/jm7010996
BindingDB Entry DOI: 10.7270/Q2Q81BCB
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM26385
PNG
(1-N-(3,5-dimethoxybenzene)-4-methyl-3-N-(2-{[4-(4-...)
Show SMILES COc1cc(OC)cc(c1)C(=O)Nc1ccc(C)c(c1)C(=O)Nc1cnc(Nc2ccc(cc2)N2CCN(C)CC2)nc1
Show InChI InChI=1S/C32H35N7O4/c1-21-5-6-24(35-30(40)22-15-27(42-3)18-28(16-22)43-4)17-29(21)31(41)36-25-19-33-32(34-20-25)37-23-7-9-26(10-8-23)39-13-11-38(2)12-14-39/h5-10,15-20H,11-14H2,1-4H3,(H,35,40)(H,36,41)(H,33,34,37)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.40n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...


J Med Chem 51: 1681-94 (2008)


Article DOI: 10.1021/jm7010996
BindingDB Entry DOI: 10.7270/Q2Q81BCB
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM26386
PNG
(Aminopyrimidine amide, 32 | N-{4-chloro-3-[(2-{[4-...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4ccc5OC(F)(F)Oc5c4)ccc3Cl)cn2)cc1
Show InChI InChI=1S/C30H26ClF2N7O4/c1-39-10-12-40(13-11-39)22-6-3-19(4-7-22)38-29-34-16-21(17-35-29)37-28(42)23-15-20(5-8-24(23)31)36-27(41)18-2-9-25-26(14-18)44-30(32,33)43-25/h2-9,14-17H,10-13H2,1H3,(H,36,41)(H,37,42)(H,34,35,38)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.80n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...


J Med Chem 51: 1681-94 (2008)


Article DOI: 10.1021/jm7010996
BindingDB Entry DOI: 10.7270/Q2Q81BCB
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 3232 total )  |  Next  |  Last  >>
Jump to: