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Found 2688 hits Enz. Inhib. hit(s) with Target = 'Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282652
PNG
(US9884828, 4-76)
Show SMILES CC(C)Nc1c(nnc2cc(Sc3ccccc3)ccc12)C(N)=O
Show InChI InChI=1S/C18H18N4OS/c1-11(2)20-16-14-9-8-13(24-12-6-4-3-5-7-12)10-15(14)21-22-17(16)18(19)23/h3-11H,1-2H3,(H2,19,23)(H,20,21)
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n/an/a 560n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282653
PNG
(US9884828, 4-78)
Show SMILES CC(C)Nc1c(nnc2cc(Nc3ccccc3)ccc12)C(N)=O
Show InChI InChI=1S/C18H19N5O/c1-11(2)20-16-14-9-8-13(21-12-6-4-3-5-7-12)10-15(14)22-23-17(16)18(19)24/h3-11,21H,1-2H3,(H2,19,24)(H,20,22)
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n/an/a 72n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282654
PNG
(US9884828, 4-80)
Show SMILES CC(C)Nc1c(nnc2cc(ccc12)-n1cccn1)C(N)=O
Show InChI InChI=1S/C15H16N6O/c1-9(2)18-13-11-5-4-10(21-7-3-6-17-21)8-12(11)19-20-14(13)15(16)22/h3-9H,1-2H3,(H2,16,22)(H,18,19)
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n/an/a 31n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282655
PNG
(US9884828, 4-85)
Show SMILES CC(C)Nc1c(nnc2cc(ccc12)N1CCCC1=O)C(N)=O
Show InChI InChI=1S/C16H19N5O2/c1-9(2)18-14-11-6-5-10(21-7-3-4-13(21)22)8-12(11)19-20-15(14)16(17)23/h5-6,8-9H,3-4,7H2,1-2H3,(H2,17,23)(H,18,19)
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n/an/a 170n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50428697
PNG
(CHEMBL2333119 | US9884828, 4-188)
Show SMILES CC(C)Nc1c(nnc2cc(ccc12)N1CCN(C)CC1)C(N)=O
Show InChI InChI=1S/C17H24N6O/c1-11(2)19-15-13-5-4-12(23-8-6-22(3)7-9-23)10-14(13)20-21-16(15)17(18)24/h4-5,10-11H,6-9H2,1-3H3,(H2,18,24)(H,19,20)
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n/an/a 53n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282657
PNG
(US9884828, 4-189)
Show SMILES COc1ccccc1Nc1ccc2c(NC(C)C)c(nnc2c1)C(N)=O
Show InChI InChI=1S/C19H21N5O2/c1-11(2)21-17-13-9-8-12(10-15(13)23-24-18(17)19(20)25)22-14-6-4-5-7-16(14)26-3/h4-11,22H,1-3H3,(H2,20,25)(H,21,23)
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n/an/a 68n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282658
PNG
(US9884828, 4-190)
Show SMILES COc1ncccc1Nc1ccc2c(NC(C)C)c(nnc2c1)C(N)=O
Show InChI InChI=1S/C18H20N6O2/c1-10(2)21-15-12-7-6-11(9-14(12)23-24-16(15)17(19)25)22-13-5-4-8-20-18(13)26-3/h4-10,22H,1-3H3,(H2,19,25)(H,21,23)
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n/an/a 31n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282659
PNG
(US9884828, 4-191)
Show SMILES CC(C)Nc1c(nnc2ccc(cc12)N1CCOCC1)C(N)=O
Show InChI InChI=1S/C16H21N5O2/c1-10(2)18-14-12-9-11(21-5-7-23-8-6-21)3-4-13(12)19-20-15(14)16(17)22/h3-4,9-10H,5-8H2,1-2H3,(H2,17,22)(H,18,19)
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n/an/a 1.30E+3n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282660
PNG
(US9884828, 4-192)
Show SMILES COc1cccc(Nc2ccc3c(NC(C)C)c(nnc3c2)C(N)=O)c1
Show InChI InChI=1S/C19H21N5O2/c1-11(2)21-17-15-8-7-13(10-16(15)23-24-18(17)19(20)25)22-12-5-4-6-14(9-12)26-3/h4-11,22H,1-3H3,(H2,20,25)(H,21,23)
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n/an/a 240n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282661
PNG
(US9884828, 5-55)
Show SMILES CC(C)Nc1c(nnc2cc(ccc12)-c1c[nH]nn1)C(N)=O
Show InChI InChI=1S/C14H15N7O/c1-7(2)17-12-9-4-3-8(11-6-16-21-19-11)5-10(9)18-20-13(12)14(15)22/h3-7H,1-2H3,(H2,15,22)(H,17,18)(H,16,19,21)
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n/an/a 13n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282662
PNG
(US9884828, 6-83)
Show SMILES CC(C)Nc1c(C)nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C19H21N3O2S/c1-12(2)20-19-13(3)21-22-18-11-15(7-10-17(18)19)14-5-8-16(9-6-14)25(4,23)24/h5-12H,1-4H3,(H,20,22)
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n/an/a 2.16E+4n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282663
PNG
(US9884828, 7-198)
Show SMILES CC(C)Nc1c(nnc2cc(CCO)ccc12)C(N)=O
Show InChI InChI=1S/C14H18N4O2/c1-8(2)16-12-10-4-3-9(5-6-19)7-11(10)17-18-13(12)14(15)20/h3-4,7-8,19H,5-6H2,1-2H3,(H2,15,20)(H,16,17)
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n/an/a 940n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282664
PNG
(US9884828, 8-200)
Show SMILES CC(C)Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)-c1nc[nH]n1
Show InChI InChI=1S/C20H20N6O2S/c1-12(2)23-18-16-9-6-14(13-4-7-15(8-5-13)29(3,27)28)10-17(16)24-25-19(18)20-21-11-22-26-20/h4-12H,1-3H3,(H,23,24)(H,21,22,26)
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n/an/a 420n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282665
PNG
(US9884828, 9-206)
Show SMILES COc1ccc(cc1-c1ccc2c(N[C@H](C)C3CC3)c(nnc2c1)C(N)=O)N1CCOC1=O
Show InChI InChI=1S/C24H25N5O4/c1-13(14-3-4-14)26-21-17-7-5-15(11-19(17)27-28-22(21)23(25)30)18-12-16(6-8-20(18)32-2)29-9-10-33-24(29)31/h5-8,11-14H,3-4,9-10H2,1-2H3,(H2,25,30)(H,26,27)/t13-/m1/s1
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n/an/a 54n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282666
PNG
(US9884828, 9-207)
Show SMILES COc1ccc(cc1-c1ccc2c(N[C@H](C)C3CC3)c(nnc2c1)C(N)=O)-n1cccn1
Show InChI InChI=1S/C24H24N6O2/c1-14(15-4-5-15)27-22-18-8-6-16(12-20(18)28-29-23(22)24(25)31)19-13-17(7-9-21(19)32-2)30-11-3-10-26-30/h3,6-15H,4-5H2,1-2H3,(H2,25,31)(H,27,28)/t14-/m1/s1
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n/an/a 280n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282667
PNG
(US9884828, 9-208)
Show SMILES COc1ccc(cc1-c1ccc2c(N[C@H](C)C3CC3)c(nnc2c1)C(N)=O)-c1ccc(cc1OC)N1CCOC1=O
Show InChI InChI=1S/C31H31N5O5/c1-17(18-4-5-18)33-28-23-9-6-20(15-25(23)34-35-29(28)30(32)37)24-14-19(7-11-26(24)39-2)22-10-8-21(16-27(22)40-3)36-12-13-41-31(36)38/h6-11,14-18H,4-5,12-13H2,1-3H3,(H2,32,37)(H,33,34)/t17-/m1/s1
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n/an/a 1.10E+3n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282668
PNG
(US9884828, 9-209)
Show SMILES COc1ccc(cc1-c1ccc2c(N[C@H](C)C3CC3)c(nnc2c1)C(N)=O)N1CCOCC1=O
Show InChI InChI=1S/C25H27N5O4/c1-14(15-3-4-15)27-23-18-7-5-16(11-20(18)28-29-24(23)25(26)32)19-12-17(6-8-21(19)33-2)30-9-10-34-13-22(30)31/h5-8,11-12,14-15H,3-4,9-10,13H2,1-2H3,(H2,26,32)(H,27,28)/t14-/m1/s1
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n/an/a 63n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282669
PNG
(US9884828, 9-210)
Show SMILES COc1ccc(cc1-c1ccc2c(N[C@H](C)C3CC3)c(nnc2c1)C(N)=O)-c1ccc(cc1OC)N1CCOCC1=O
Show InChI InChI=1S/C32H33N5O5/c1-18(19-4-5-19)34-30-24-9-6-21(15-26(24)35-36-31(30)32(33)39)25-14-20(7-11-27(25)40-2)23-10-8-22(16-28(23)41-3)37-12-13-42-17-29(37)38/h6-11,14-16,18-19H,4-5,12-13,17H2,1-3H3,(H2,33,39)(H,34,35)/t18-/m1/s1
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n/an/a 490n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282670
PNG
(US9884828, 9-213)
Show SMILES C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccc(cc1)N1CCOC1=O)C(N)=O)C1CC1
Show InChI InChI=1S/C23H23N5O3/c1-13(14-2-3-14)25-20-18-9-6-16(12-19(18)26-27-21(20)22(24)29)15-4-7-17(8-5-15)28-10-11-31-23(28)30/h4-9,12-14H,2-3,10-11H2,1H3,(H2,24,29)(H,25,26)/t13-/m1/s1
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n/an/a 1n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282671
PNG
(US9884828, 10-87)
Show SMILES CC(C)Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)C#C
Show InChI InChI=1S/C20H19N3O2S/c1-5-18-20(21-13(2)3)17-11-8-15(12-19(17)23-22-18)14-6-9-16(10-7-14)26(4,24)25/h1,6-13H,2-4H3,(H,21,23)
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n/an/a 990n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282672
PNG
(US9884828, 11-218)
Show SMILES COc1cc(ccc1-c1ccc2c(N[C@H](C)C3CC3)c(nnc2c1)C(N)=O)-c1ncccc1F
Show InChI InChI=1S/C26H24FN5O2/c1-14(15-5-6-15)30-24-19-10-7-16(12-21(19)31-32-25(24)26(28)33)18-9-8-17(13-22(18)34-2)23-20(27)4-3-11-29-23/h3-4,7-15H,5-6H2,1-2H3,(H2,28,33)(H,30,31)/t14-/m1/s1
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n/an/a 43n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282673
PNG
(US9884828, 11-220)
Show SMILES COc1cc(ccc1-c1ccc2c(N[C@H](C)C3CC3)c(nnc2c1)C(N)=O)-c1nccnc1OC
Show InChI InChI=1S/C26H26N6O3/c1-14(15-4-5-15)30-23-19-9-6-16(12-20(19)31-32-24(23)25(27)33)18-8-7-17(13-21(18)34-2)22-26(35-3)29-11-10-28-22/h6-15H,4-5H2,1-3H3,(H2,27,33)(H,30,31)/t14-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282674
PNG
(US9884828, 11-221)
Show SMILES COc1cc(ccc1-c1ccc2c(N[C@H](C)C3CC3)c(nnc2c1)C(N)=O)-c1nccn1C
Show InChI InChI=1S/C25H26N6O2/c1-14(15-4-5-15)28-22-19-9-6-16(12-20(19)29-30-23(22)24(26)32)18-8-7-17(13-21(18)33-3)25-27-10-11-31(25)2/h6-15H,4-5H2,1-3H3,(H2,26,32)(H,28,29)/t14-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50428694
PNG
(CHEMBL2333122 | US9884828, 12-227)
Show SMILES CNC(=O)c1nnc2cc(ccc2c1NC(C)C)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C20H22N4O3S/c1-12(2)22-18-16-10-7-14(11-17(16)23-24-19(18)20(25)21-3)13-5-8-15(9-6-13)28(4,26)27/h5-12H,1-4H3,(H,21,25)(H,22,23)
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n/an/a 410n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282676
PNG
(US9884828, 12-229)
Show SMILES CNC(=O)c1nnc2cc(ccc2c1NC)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C18H18N4O3S/c1-19-16-14-9-6-12(10-15(14)21-22-17(16)18(23)20-2)11-4-7-13(8-5-11)26(3,24)25/h4-10H,1-3H3,(H,19,21)(H,20,23)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50428693
PNG
(CHEMBL2333123 | US9884828, 12-231)
Show SMILES CNC(=O)c1nnc2cc(ccc2c1N[C@H](C)C1CC1)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C22H24N4O3S/c1-13(14-4-5-14)24-20-18-11-8-16(12-19(18)25-26-21(20)22(27)23-2)15-6-9-17(10-7-15)30(3,28)29/h6-14H,4-5H2,1-3H3,(H,23,27)(H,24,25)/t13-/m1/s1
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n/an/a 170n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282678
PNG
(US9884828, 13-233)
Show SMILES CC(C)Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)-c1ncc[nH]1
Show InChI InChI=1S/C21H21N5O2S/c1-13(2)24-19-17-9-6-15(14-4-7-16(8-5-14)29(3,27)28)12-18(17)25-26-20(19)21-22-10-11-23-21/h4-13H,1-3H3,(H,22,23)(H,24,25)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282679
PNG
(US9884828, 14-235)
Show SMILES CNC(=O)c1nnc2cc(ccc2c1N[C@H](C)C1CC1)C(C)=C
Show InChI InChI=1S/C18H22N4O/c1-10(2)13-7-8-14-15(9-13)21-22-17(18(23)19-4)16(14)20-11(3)12-5-6-12/h7-9,11-12H,1,5-6H2,2-4H3,(H,19,23)(H,20,21)/t11-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282680
PNG
(US9884828, 14-236)
Show SMILES CNC(=O)c1nnc2cc(ccc2c1N[C@H](C)C1CC1)C1CC1
Show InChI InChI=1S/C18H22N4O/c1-10(11-3-4-11)20-16-14-8-7-13(12-5-6-12)9-15(14)21-22-17(16)18(23)19-2/h7-12H,3-6H2,1-2H3,(H,19,23)(H,20,21)/t10-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282588
PNG
(US9884828, 2-47)
Show SMILES CC(C)Nc1c(nnc2cc(ccc12)-c1ccccc1F)C(N)=O
Show InChI InChI=1S/C18H17FN4O/c1-10(2)21-16-13-8-7-11(12-5-3-4-6-14(12)19)9-15(13)22-23-17(16)18(20)24/h3-10H,1-2H3,(H2,20,24)(H,21,22)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282589
PNG
(US9884828, 2-49)
Show SMILES CC(C)Nc1c(nnc2cc(ccc12)-c1ccc(cc1)N1CCOCC1)C(N)=O
Show InChI InChI=1S/C22H25N5O2/c1-14(2)24-20-18-8-5-16(13-19(18)25-26-21(20)22(23)28)15-3-6-17(7-4-15)27-9-11-29-12-10-27/h3-8,13-14H,9-12H2,1-2H3,(H2,23,28)(H,24,25)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282590
PNG
(US9884828, 2-51)
Show SMILES CC(C)Nc1c(nnc2cc(ccc12)-c1cccc(c1)N1CCOCC1)C(N)=O
Show InChI InChI=1S/C22H25N5O2/c1-14(2)24-20-18-7-6-16(13-19(18)25-26-21(20)22(23)28)15-4-3-5-17(12-15)27-8-10-29-11-9-27/h3-7,12-14H,8-11H2,1-2H3,(H2,23,28)(H,24,25)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50428700
PNG
(CHEMBL2333116 | US9884828, 2-53)
Show SMILES CC(C)Nc1c(nnc2cc(ccc12)-c1cn[nH]c1)C(N)=O
Show InChI InChI=1S/C15H16N6O/c1-8(2)19-13-11-4-3-9(10-6-17-18-7-10)5-12(11)20-21-14(13)15(16)22/h3-8H,1-2H3,(H2,16,22)(H,17,18)(H,19,20)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282592
PNG
(US9884828, 2-57)
Show SMILES CC(C)Nc1c(nnc2cc(ccc12)-c1cccnc1)C(N)=O
Show InChI InChI=1S/C17H17N5O/c1-10(2)20-15-13-6-5-11(12-4-3-7-19-9-12)8-14(13)21-22-16(15)17(18)23/h3-10H,1-2H3,(H2,18,23)(H,20,21)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282593
PNG
(US9884828, 2-88)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1ccc2c(NC34CC5CC(CC(C5)C3)C4)c(nnc2c1)C(N)=O
Show InChI InChI=1S/C26H28N4O3S/c1-34(32,33)20-5-2-18(3-6-20)19-4-7-21-22(11-19)29-30-24(25(27)31)23(21)28-26-12-15-8-16(13-26)10-17(9-15)14-26/h2-7,11,15-17H,8-10,12-14H2,1H3,(H2,27,31)(H,28,29)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282594
PNG
(US9884828, 2-89)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1ccc2c(NCC3CCOCC3)c(nnc2c1)C(N)=O
Show InChI InChI=1S/C22H24N4O4S/c1-31(28,29)17-5-2-15(3-6-17)16-4-7-18-19(12-16)25-26-21(22(23)27)20(18)24-13-14-8-10-30-11-9-14/h2-7,12,14H,8-11,13H2,1H3,(H2,23,27)(H,24,25)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282595
PNG
(US9884828, 2-90)
Show SMILES C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)C(N)=O)C1CCOCC1
Show InChI InChI=1S/C23H26N4O4S/c1-14(15-9-11-31-12-10-15)25-21-19-8-5-17(13-20(19)26-27-22(21)23(24)28)16-3-6-18(7-4-16)32(2,29)30/h3-8,13-15H,9-12H2,1-2H3,(H2,24,28)(H,25,26)/t14-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282596
PNG
(US9884828, 2-91)
Show SMILES CC(C)(C)Nc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)C(N)=O
Show InChI InChI=1S/C20H22N4O3S/c1-20(2,3)22-17-15-10-7-13(11-16(15)23-24-18(17)19(21)25)12-5-8-14(9-6-12)28(4,26)27/h5-11H,1-4H3,(H2,21,25)(H,22,23)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50428714
PNG
(CHEMBL2333130 | US9884828, 2-92)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1ccc2c(NCC3CC3)c(nnc2c1)C(N)=O
Show InChI InChI=1S/C20H20N4O3S/c1-28(26,27)15-7-4-13(5-8-15)14-6-9-16-17(10-14)23-24-19(20(21)25)18(16)22-11-12-2-3-12/h4-10,12H,2-3,11H2,1H3,(H2,21,25)(H,22,23)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50428713
PNG
(CHEMBL2333131 | US9884828, 2-93)
Show SMILES CCNc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)C(N)=O
Show InChI InChI=1S/C18H18N4O3S/c1-3-20-16-14-9-6-12(10-15(14)21-22-17(16)18(19)23)11-4-7-13(8-5-11)26(2,24)25/h4-10H,3H2,1-2H3,(H2,19,23)(H,20,21)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50428709
PNG
(CHEMBL2333135 | US9884828, 2-94)
Show SMILES CNc1c(nnc2cc(ccc12)-c1ccc(cc1)S(C)(=O)=O)C(N)=O
Show InChI InChI=1S/C17H16N4O3S/c1-19-15-13-8-5-11(9-14(13)20-21-16(15)17(18)22)10-3-6-12(7-4-10)25(2,23)24/h3-9H,1-2H3,(H2,18,22)(H,19,20)
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n/an/a 120n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282600
PNG
(US9884828, 2-95)
Show SMILES CC(C)Nc1c(nnc2cc(C=C)ccc12)C(N)=O
Show InChI InChI=1S/C14H16N4O/c1-4-9-5-6-10-11(7-9)17-18-13(14(15)19)12(10)16-8(2)3/h4-8H,1H2,2-3H3,(H2,15,19)(H,16,17)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282601
PNG
(US9884828, 2-96)
Show SMILES COc1ccccc1-c1ccc2c(NC(C)C)c(nnc2c1)C(N)=O
Show InChI InChI=1S/C19H20N4O2/c1-11(2)21-17-14-9-8-12(13-6-4-5-7-16(13)25-3)10-15(14)22-23-18(17)19(20)24/h4-11H,1-3H3,(H2,20,24)(H,21,22)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282602
PNG
(US9884828, 2-97)
Show SMILES COc1cccc(c1)-c1ccc2c(NC(C)C)c(nnc2c1)C(N)=O
Show InChI InChI=1S/C19H20N4O2/c1-11(2)21-17-15-8-7-13(12-5-4-6-14(9-12)25-3)10-16(15)22-23-18(17)19(20)24/h4-11H,1-3H3,(H2,20,24)(H,21,22)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282603
PNG
(US9884828, 2-98)
Show SMILES COc1ccc(F)cc1-c1ccc2c(NC(C)C)c(nnc2c1)C(N)=O
Show InChI InChI=1S/C19H19FN4O2/c1-10(2)22-17-13-6-4-11(8-15(13)23-24-18(17)19(21)25)14-9-12(20)5-7-16(14)26-3/h4-10H,1-3H3,(H2,21,25)(H,22,23)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282604
PNG
(US9884828, 2-99)
Show SMILES CC(C)Nc1c(nnc2cc(ccc12)C(C)=C)C(N)=O
Show InChI InChI=1S/C15H18N4O/c1-8(2)10-5-6-11-12(7-10)18-19-14(15(16)20)13(11)17-9(3)4/h5-7,9H,1H2,2-4H3,(H2,16,20)(H,17,18)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50428703
PNG
(CHEMBL2333113 | US9884828, 2-100)
Show SMILES C[C@@H](Nc1c(nnc2cc(ccc12)-c1ccncc1)C(N)=O)C1CC1
Show InChI InChI=1S/C19H19N5O/c1-11(12-2-3-12)22-17-15-5-4-14(13-6-8-21-9-7-13)10-16(15)23-24-18(17)19(20)25/h4-12H,2-3H2,1H3,(H2,20,25)(H,22,23)/t11-/m1/s1
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US Patent
n/an/a<6n/an/an/an/a7.525



Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282606
PNG
(US9884828, 2-101)
Show SMILES C[C@@H](Nc1c(nnc2cc(ccc12)-c1cnn(C)c1)C(N)=O)C1CC1
Show InChI InChI=1S/C18H20N6O/c1-10(11-3-4-11)21-16-14-6-5-12(13-8-20-24(2)9-13)7-15(14)22-23-17(16)18(19)25/h5-11H,3-4H2,1-2H3,(H2,19,25)(H,21,22)/t10-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282607
PNG
(US9884828, 2-102)
Show SMILES CN(C)C(=O)c1cccc(c1)-c1ccc2cc(nnc2c1)C(N)=O
Show InChI InChI=1S/C18H16N4O2/c1-22(2)18(24)14-5-3-4-11(8-14)12-6-7-13-10-16(17(19)23)21-20-15(13)9-12/h3-10H,1-2H3,(H2,19,23)
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM282608
PNG
(US9884828, 2-103)
Show SMILES COc1ccccc1-c1ccc2c(N[C@H](C)C3CC3)c(nnc2c1)C(N)=O
Show InChI InChI=1S/C21H22N4O2/c1-12(13-7-8-13)23-19-16-10-9-14(15-5-3-4-6-18(15)27-2)11-17(16)24-25-20(19)21(22)26/h3-6,9-13H,7-8H2,1-2H3,(H2,22,26)(H,23,24)/t12-/m1/s1
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Imago Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds as described herein (compounds of Formula I, e.g., compounds of the above Examples) are tested for their in vitro kinase activities using v...


US Patent US9884828 (2018)

More data for this
Ligand-Target Pair
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