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Compile Data Set for Download or QSAR

Found 1048 hits Enz. Inhib. hit(s) with Target = 'Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185578
PNG
(US9156845, 201)
Show SMILES C1CN(CCO1)c1ncnc2[nH]cc(-c3cccc(c3)-c3ncon3)c12
Show InChI InChI=1S/C18H16N6O2/c1-2-12(8-13(3-1)16-22-11-26-23-16)14-9-19-17-15(14)18(21-10-20-17)24-4-6-25-7-5-24/h1-3,8-11H,4-7H2,(H,19,20,21)
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n/an/a 475n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185579
PNG
(US9156845, 202)
Show SMILES Cc1cc(on1)C1CN(CCO1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12
Show InChI InChI=1S/C21H18N6O2/c1-13-7-17(29-26-13)18-11-27(5-6-28-18)21-19-16(10-23-20(19)24-12-25-21)15-4-2-3-14(8-15)9-22/h2-4,7-8,10,12,18H,5-6,11H2,1H3,(H,23,24,25)
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185544
PNG
(US9156845, 203)
Show SMILES Cc1c(cccc1-c1c[nH]c2ncnc(N3CCOCC3)c12)C#N
Show InChI InChI=1S/C18H17N5O/c1-12-13(9-19)3-2-4-14(12)15-10-20-17-16(15)18(22-11-21-17)23-5-7-24-8-6-23/h2-4,10-11H,5-8H2,1H3,(H,20,21,22)
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185545
PNG
(US9156845, 204)
Show SMILES O=c1cc(cc[nH]1)-c1c[nH]c2ncnc(N3CCOCC3)c12
Show InChI InChI=1S/C15H15N5O2/c21-12-7-10(1-2-16-12)11-8-17-14-13(11)15(19-9-18-14)20-3-5-22-6-4-20/h1-2,7-9H,3-6H2,(H,16,21)(H,17,18,19)
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185546
PNG
(US9156845, 205)
Show SMILES C1CN(CCO1)c1ncnc2[nH]cc(-c3cnc4sccn34)c12
Show InChI InChI=1S/C15H14N6OS/c1-4-22-5-2-20(1)14-12-10(7-16-13(12)18-9-19-14)11-8-17-15-21(11)3-6-23-15/h3,6-9H,1-2,4-5H2,(H,16,18,19)
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185547
PNG
(US9156845, 206)
Show SMILES N#Cc1cccc(c1)-c1c[nH]c2ncnc(N3C[C@@H]4CCO[C@@H]4C3)c12
Show InChI InChI=1S/C19H17N5O/c20-7-12-2-1-3-13(6-12)15-8-21-18-17(15)19(23-11-22-18)24-9-14-4-5-25-16(14)10-24/h1-3,6,8,11,14,16H,4-5,9-10H2,(H,21,22,23)/t14-,16+/m0/s1
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185548
PNG
(US9156845, 207)
Show SMILES N#Cc1cccc(c1)-c1c[nH]c2ncnc(N3C[C@@H]4COC[C@@H]4C3)c12
Show InChI InChI=1S/C19H17N5O/c20-5-12-2-1-3-13(4-12)16-6-21-18-17(16)19(23-11-22-18)24-7-14-9-25-10-15(14)8-24/h1-4,6,11,14-15H,7-10H2,(H,21,22,23)/t14-,15+
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185549
PNG
(US9156845, 208)
Show SMILES N#Cc1cccc(c1)-c1c[nH]c2ncnc(N3CCO[C@H]4CCC[C@@H]34)c12
Show InChI InChI=1S/C20H19N5O/c21-10-13-3-1-4-14(9-13)15-11-22-19-18(15)20(24-12-23-19)25-7-8-26-17-6-2-5-16(17)25/h1,3-4,9,11-12,16-17H,2,5-8H2,(H,22,23,24)/t16-,17+/m1/s1
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US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185550
PNG
(US9156845, 209)
Show SMILES [C-]#[N+]C1CN(CCO1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12
Show InChI InChI=1S/C18H14N6O/c1-20-15-10-24(5-6-25-15)18-16-14(9-21-17(16)22-11-23-18)13-4-2-3-12(7-13)8-19/h2-4,7,9,11,15H,5-6,10H2,(H,21,22,23)
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US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185551
PNG
(US9156845, 210)
Show SMILES CC1(C)CN(CCO1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12
Show InChI InChI=1S/C19H19N5O/c1-19(2)11-24(6-7-25-19)18-16-15(10-21-17(16)22-12-23-18)14-5-3-4-13(8-14)9-20/h3-5,8,10,12H,6-7,11H2,1-2H3,(H,21,22,23)
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185552
PNG
(US9156845, 211)
Show SMILES N#Cc1ccc(s1)-c1c[nH]c2ncnc(N3CCOCC3)c12
Show InChI InChI=1S/C15H13N5OS/c16-7-10-1-2-12(22-10)11-8-17-14-13(11)15(19-9-18-14)20-3-5-21-6-4-20/h1-2,8-9H,3-6H2,(H,17,18,19)
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185553
PNG
(US9156845, 212)
Show SMILES C1CN(CCO1)c1ncnc2[nH]cc(-c3cnc4cccnn34)c12
Show InChI InChI=1S/C16H15N7O/c1-2-13-17-9-12(23(13)21-3-1)11-8-18-15-14(11)16(20-10-19-15)22-4-6-24-7-5-22/h1-3,8-10H,4-7H2,(H,18,19,20)
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185512
PNG
(US9156845, 166 | US9156845, 213)
Show SMILES Cc1noc(n1)C1CN(CCO1)c1ncnc2[nH]cc(-c3cccc(C#N)c3F)c12
Show InChI InChI=1S/C20H16FN7O2/c1-11-26-20(30-27-11)15-9-28(5-6-29-15)19-16-14(8-23-18(16)24-10-25-19)13-4-2-3-12(7-22)17(13)21/h2-4,8,10,15H,5-6,9H2,1H3,(H,23,24,25)
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185556
PNG
(US9156845, 215)
Show SMILES NC(=O)c1cccc(c1)-c1c[nH]c2ncnc(N3CCOCC3)c12
Show InChI InChI=1S/C17H17N5O2/c18-15(23)12-3-1-2-11(8-12)13-9-19-16-14(13)17(21-10-20-16)22-4-6-24-7-5-22/h1-3,8-10H,4-7H2,(H2,18,23)(H,19,20,21)
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185557
PNG
(US9156845, 216)
Show SMILES C1CN(CCO1)c1ncnc2[nH]cc(-c3cnn4cccnc34)c12
Show InChI InChI=1S/C16H15N7O/c1-2-17-15-12(9-21-23(15)3-1)11-8-18-14-13(11)16(20-10-19-14)22-4-6-24-7-5-22/h1-3,8-10H,4-7H2,(H,18,19,20)
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185558
PNG
(US9156845, 217)
Show SMILES Cn1cc(cc1C#N)-c1c[nH]c2ncnc(N3CCOCC3)c12
Show InChI InChI=1S/C16H16N6O/c1-21-9-11(6-12(21)7-17)13-8-18-15-14(13)16(20-10-19-15)22-2-4-23-5-3-22/h6,8-10H,2-5H2,1H3,(H,18,19,20)
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185559
PNG
(US9156845, 218)
Show SMILES Cc1nc2sccn2c1-c1c[nH]c2ncnc(N3CCOCC3)c12
Show InChI InChI=1S/C16H16N6OS/c1-10-13(22-4-7-24-16(22)20-10)11-8-17-14-12(11)15(19-9-18-14)21-2-5-23-6-3-21/h4,7-9H,2-3,5-6H2,1H3,(H,17,18,19)
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US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM50059310
PNG
(CHEMBL3393447 | US9156845, 219)
Show SMILES N#Cc1cccc(c1)-c1c[nH]c2ncnc(N3CCOC(C3)c3ccno3)c12
Show InChI InChI=1S/C20H16N6O2/c21-9-13-2-1-3-14(8-13)15-10-22-19-18(15)20(24-12-23-19)26-6-7-27-17(11-26)16-4-5-25-28-16/h1-5,8,10,12,17H,6-7,11H2,(H,22,23,24)
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US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185560
PNG
(US9156845, 220)
Show SMILES Cn1cc(nc1C#N)-c1c[nH]c2ncnc(N3CCOCC3)c12
Show InChI InChI=1S/C15H15N7O/c1-21-8-11(20-12(21)6-16)10-7-17-14-13(10)15(19-9-18-14)22-2-4-23-5-3-22/h7-9H,2-5H2,1H3,(H,17,18,19)
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185475
PNG
(US9156845, 128)
Show SMILES FC1(F)CCCN(C1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12
Show InChI InChI=1S/C18H15F2N5/c19-18(20)5-2-6-25(10-18)17-15-14(9-22-16(15)23-11-24-17)13-4-1-3-12(7-13)8-21/h1,3-4,7,9,11H,2,5-6,10H2,(H,22,23,24)
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185476
PNG
(US9156845, 129)
Show SMILES NC1CCCN(C1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12
Show InChI InChI=1S/C18H18N6/c19-8-12-3-1-4-13(7-12)15-9-21-17-16(15)18(23-11-22-17)24-6-2-5-14(20)10-24/h1,3-4,7,9,11,14H,2,5-6,10,20H2,(H,21,22,23)
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185477
PNG
(US9156845, 130)
Show SMILES FC(F)c1nc(CC2CN(CCO2)c2ncnc3[nH]cc(-c4cccc(c4)C#N)c23)no1
Show InChI InChI=1S/C21H17F2N7O2/c22-18(23)21-28-16(29-32-21)7-14-10-30(4-5-31-14)20-17-15(9-25-19(17)26-11-27-20)13-3-1-2-12(6-13)8-24/h1-3,6,9,11,14,18H,4-5,7,10H2,(H,25,26,27)
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185478
PNG
(US9156845, 131)
Show SMILES N#Cc1cccc(c1)-c1c[nH]c2ncnc(N3CCOC(C3)c3nccs3)c12
Show InChI InChI=1S/C20H16N6OS/c21-9-13-2-1-3-14(8-13)15-10-23-18-17(15)19(25-12-24-18)26-5-6-27-16(11-26)20-22-4-7-28-20/h1-4,7-8,10,12,16H,5-6,11H2,(H,23,24,25)
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US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185479
PNG
(US9156845, 132)
Show SMILES O=C1CCN(CC1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12
Show InChI InChI=1S/C18H15N5O/c19-9-12-2-1-3-13(8-12)15-10-20-17-16(15)18(22-11-21-17)23-6-4-14(24)5-7-23/h1-3,8,10-11H,4-7H2,(H,20,21,22)
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US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185480
PNG
(US9156845, 133)
Show SMILES OCC1(F)CCN(CC1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12
Show InChI InChI=1S/C19H18FN5O/c20-19(11-26)4-6-25(7-5-19)18-16-15(10-22-17(16)23-12-24-18)14-3-1-2-13(8-14)9-21/h1-3,8,10,12,26H,4-7,11H2,(H,22,23,24)
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US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185481
PNG
(US9156845, 134)
Show SMILES Oc1cccc(c1)C1CN(CCO1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12
Show InChI InChI=1S/C23H19N5O2/c24-11-15-3-1-4-16(9-15)19-12-25-22-21(19)23(27-14-26-22)28-7-8-30-20(13-28)17-5-2-6-18(29)10-17/h1-6,9-10,12,14,20,29H,7-8,13H2,(H,25,26,27)
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Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185482
PNG
(US9156845, 135)
Show SMILES N#Cc1cccc(c1)-c1c[nH]c2ncnc(N3CCOC(C3)c3noc(n3)C3CC3)c12
Show InChI InChI=1S/C22H19N7O2/c23-9-13-2-1-3-15(8-13)16-10-24-20-18(16)21(26-12-25-20)29-6-7-30-17(11-29)19-27-22(31-28-19)14-4-5-14/h1-3,8,10,12,14,17H,4-7,11H2,(H,24,25,26)
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US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185483
PNG
(US9156845, 136)
Show SMILES FC1(F)CCN(C1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12
Show InChI InChI=1S/C17H13F2N5/c18-17(19)4-5-24(9-17)16-14-13(8-21-15(14)22-10-23-16)12-3-1-2-11(6-12)7-20/h1-3,6,8,10H,4-5,9H2,(H,21,22,23)
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Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185484
PNG
(US9156845, 137)
Show SMILES N#Cc1cccc(OCC2CN(CCO2)c2ncnc3[nH]cc(-c4cccc(c4)C#N)c23)c1
Show InChI InChI=1S/C25H20N6O2/c26-11-17-3-1-5-19(9-17)22-13-28-24-23(22)25(30-16-29-24)31-7-8-32-21(14-31)15-33-20-6-2-4-18(10-20)12-27/h1-6,9-10,13,16,21H,7-8,14-15H2,(H,28,29,30)
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Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185485
PNG
(US9156845, 138)
Show SMILES OC1CCCN(C1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12
Show InChI InChI=1S/C18H17N5O/c19-8-12-3-1-4-13(7-12)15-9-20-17-16(15)18(22-11-21-17)23-6-2-5-14(24)10-23/h1,3-4,7,9,11,14,24H,2,5-6,10H2,(H,20,21,22)
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Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185486
PNG
(US9156845, 139)
Show SMILES NC(=O)C1CCCN(C1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12
Show InChI InChI=1S/C19H18N6O/c20-8-12-3-1-4-13(7-12)15-9-22-18-16(15)19(24-11-23-18)25-6-2-5-14(10-25)17(21)26/h1,3-4,7,9,11,14H,2,5-6,10H2,(H2,21,26)(H,22,23,24)
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Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185487
PNG
(US9156845, 140)
Show SMILES CCC1CN(CCO1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12
Show InChI InChI=1S/C19H19N5O/c1-2-15-11-24(6-7-25-15)19-17-16(10-21-18(17)22-12-23-19)14-5-3-4-13(8-14)9-20/h3-5,8,10,12,15H,2,6-7,11H2,1H3,(H,21,22,23)
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185488
PNG
(US9156845, 141)
Show SMILES N#Cc1cccc(c1)-c1c[nH]c2ncnc(N3CCOC(C3)c3ccncn3)c12
Show InChI InChI=1S/C21H17N7O/c22-9-14-2-1-3-15(8-14)16-10-24-20-19(16)21(27-13-26-20)28-6-7-29-18(11-28)17-4-5-23-12-25-17/h1-5,8,10,12-13,18H,6-7,11H2,(H,24,26,27)
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185489
PNG
(US9156845, 142)
Show SMILES N#Cc1cccc(c1)-c1c[nH]c2ncnc(N3CCOC(C3)c3nc(no3)C3CC3)c12
Show InChI InChI=1S/C22H19N7O2/c23-9-13-2-1-3-15(8-13)16-10-24-20-18(16)21(26-12-25-20)29-6-7-30-17(11-29)22-27-19(28-31-22)14-4-5-14/h1-3,8,10,12,14,17H,4-7,11H2,(H,24,25,26)
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185490
PNG
(US9156845, 143)
Show SMILES CN(C)CC1CN(CCO1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12
Show InChI InChI=1S/C20H22N6O/c1-25(2)11-16-12-26(6-7-27-16)20-18-17(10-22-19(18)23-13-24-20)15-5-3-4-14(8-15)9-21/h3-5,8,10,13,16H,6-7,11-12H2,1-2H3,(H,22,23,24)
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US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185491
PNG
(US9156845, 144)
Show SMILES N#Cc1cccc(c1)-c1c[nH]c2ncnc(Nc3cn[nH]c3)c12
Show InChI InChI=1S/C16H11N7/c17-5-10-2-1-3-11(4-10)13-8-18-15-14(13)16(20-9-19-15)23-12-6-21-22-7-12/h1-4,6-9H,(H,21,22)(H2,18,19,20,23)
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185492
PNG
(US9156845, 145)
Show SMILES Cc1nc(CC2CN(CCO2)c2ncnc3[nH]cc(-c4cccc(c4)C#N)c23)no1
Show InChI InChI=1S/C21H19N7O2/c1-13-26-18(27-30-13)8-16-11-28(5-6-29-16)21-19-17(10-23-20(19)24-12-25-21)15-4-2-3-14(7-15)9-22/h2-4,7,10,12,16H,5-6,8,11H2,1H3,(H,23,24,25)
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185493
PNG
(US9156845, 146)
Show SMILES Cc1nnc(o1)C1CCCN(C1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12
Show InChI InChI=1S/C21H19N7O/c1-13-26-27-21(29-13)16-6-3-7-28(11-16)20-18-17(10-23-19(18)24-12-25-20)15-5-2-4-14(8-15)9-22/h2,4-5,8,10,12,16H,3,6-7,11H2,1H3,(H,23,24,25)
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185494
PNG
(US9156845, 147)
Show SMILES COc1cc(cc(c1)-c1c[nH]c2ncnc(N(C)C)c12)C#N
Show InChI InChI=1S/C16H15N5O/c1-21(2)16-14-13(8-18-15(14)19-9-20-16)11-4-10(7-17)5-12(6-11)22-3/h4-6,8-9H,1-3H3,(H,18,19,20)
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185495
PNG
(US9156845, 148)
Show SMILES CCn1cc(cn1)-c1c[nH]c2ncnc(N3CCOCC3)c12
Show InChI InChI=1S/C15H18N6O/c1-2-21-9-11(7-19-21)12-8-16-14-13(12)15(18-10-17-14)20-3-5-22-6-4-20/h7-10H,2-6H2,1H3,(H,16,17,18)
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US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM50059312
PNG
(CHEMBL3393441 | US9156845, 149)
Show SMILES Cc1cncc(c1)-c1c[nH]c2ncnc(N3CCOCC3)c12
Show InChI InChI=1S/C16H17N5O/c1-11-6-12(8-17-7-11)13-9-18-15-14(13)16(20-10-19-15)21-2-4-22-5-3-21/h6-10H,2-5H2,1H3,(H,18,19,20)
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US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185496
PNG
(US9156845, 150)
Show SMILES Clc1cncc(c1)-c1c[nH]c2ncnc(N3CCOCC3)c12
Show InChI InChI=1S/C15H14ClN5O/c16-11-5-10(6-17-7-11)12-8-18-14-13(12)15(20-9-19-14)21-1-3-22-4-2-21/h5-9H,1-4H2,(H,18,19,20)
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US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185497
PNG
(US9156845, 151)
Show SMILES COc1cncc(n1)-c1c[nH]c2ncnc(N3CCOCC3)c12
Show InChI InChI=1S/C15H16N6O2/c1-22-12-8-16-7-11(20-12)10-6-17-14-13(10)15(19-9-18-14)21-2-4-23-5-3-21/h6-9H,2-5H2,1H3,(H,17,18,19)
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Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185498
PNG
(US9156845, 152)
Show SMILES Cc1nn(C)cc1-c1c[nH]c2ncnc(N3CCOCC3)c12
Show InChI InChI=1S/C15H18N6O/c1-10-12(8-20(2)19-10)11-7-16-14-13(11)15(18-9-17-14)21-3-5-22-6-4-21/h7-9H,3-6H2,1-2H3,(H,16,17,18)
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US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185499
PNG
(US9156845, 153)
Show SMILES C[C@H]1COCCN1c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12
Show InChI InChI=1S/C18H17N5O/c1-12-10-24-6-5-23(12)18-16-15(9-20-17(16)21-11-22-18)14-4-2-3-13(7-14)8-19/h2-4,7,9,11-12H,5-6,10H2,1H3,(H,20,21,22)/t12-/m0/s1
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n/an/a 165n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185500
PNG
(US9156845, 154)
Show SMILES Cc1nc(N2CCOCC2)c2c(c[nH]c2n1)-c1cccc(C#N)c1F
Show InChI InChI=1S/C18H16FN5O/c1-11-22-17-15(18(23-11)24-5-7-25-8-6-24)14(10-21-17)13-4-2-3-12(9-20)16(13)19/h2-4,10H,5-8H2,1H3,(H,21,22,23)
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n/an/a 365n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185501
PNG
(US9156845, 155)
Show SMILES O[C@@H]1CCCN(C1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12
Show InChI InChI=1S/C18H17N5O/c19-8-12-3-1-4-13(7-12)15-9-20-17-16(15)18(22-11-21-17)23-6-2-5-14(24)10-23/h1,3-4,7,9,11,14,24H,2,5-6,10H2,(H,20,21,22)/t14-/m1/s1
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n/an/a 37n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185502
PNG
(US9156845, 156)
Show SMILES OC1CCCN(C1)c1ncnc2[nH]cc(-c3cccc(F)c3)c12
Show InChI InChI=1S/C17H17FN4O/c18-12-4-1-3-11(7-12)14-8-19-16-15(14)17(21-10-20-16)22-6-2-5-13(23)9-22/h1,3-4,7-8,10,13,23H,2,5-6,9H2,(H,19,20,21)
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n/an/a 86n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185503
PNG
(US9156845, 157)
Show SMILES COc1ccc(F)cc1-c1c[nH]c2ncnc(N3CCOC(C3)c3noc(C)n3)c12
Show InChI InChI=1S/C20H19FN6O3/c1-11-25-18(26-30-11)16-9-27(5-6-29-16)20-17-14(8-22-19(17)23-10-24-20)13-7-12(21)3-4-15(13)28-2/h3-4,7-8,10,16H,5-6,9H2,1-2H3,(H,22,23,24)
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n/an/a 46n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185504
PNG
(US9156845, 158)
Show SMILES FC1CCN(CC1)c1ncnc2[nH]cc(-c3cccc(C#N)c3F)c12
Show InChI InChI=1S/C18H15F2N5/c19-12-4-6-25(7-5-12)18-15-14(9-22-17(15)23-10-24-18)13-3-1-2-11(8-21)16(13)20/h1-3,9-10,12H,4-7H2,(H,22,23,24)
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n/an/a 86n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
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