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Compile Data Set for Download or QSAR

Found 310 hits Enz. Inhib. hit(s) with Target = 'Leucine-rich repeat serine/threonine-protein kinase 2 G2019S'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM50059307
PNG
(CHEMBL3393439 | US9156845, 1)
Show SMILES Cn1cc(cn1)-c1c[nH]c2ncnc(N3CCOCC3)c12
Show InChI InChI=1S/C14H16N6O/c1-19-8-10(6-18-19)11-7-15-13-12(11)14(17-9-16-13)20-2-4-21-5-3-20/h6-9H,2-5H2,1H3,(H,15,16,17)
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n/an/a 36n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185570
PNG
(US9156845, 2)
Show SMILES Cc1[nH]c2ncnc(N3CCOCC3)c2c1-c1cccc(c1)C#N
Show InChI InChI=1S/C18H17N5O/c1-12-15(14-4-2-3-13(9-14)10-19)16-17(22-12)20-11-21-18(16)23-5-7-24-8-6-23/h2-4,9,11H,5-8H2,1H3,(H,20,21,22)
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM50059314
PNG
(CHEMBL3393359 | US9156845, 3)
Show SMILES N#Cc1cccc(n1)-c1c[nH]c2ncnc(N3CCOCC3)c12
Show InChI InChI=1S/C16H14N6O/c17-8-11-2-1-3-13(21-11)12-9-18-15-14(12)16(20-10-19-15)22-4-6-23-7-5-22/h1-3,9-10H,4-7H2,(H,18,19,20)
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n/an/a 26n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM50059277
PNG
(CHEMBL3393348 | US9156845, 4)
Show SMILES N#Cc1cccc(c1)-c1c[nH]c2ncnc(N3CCOCC3)c12
Show InChI InChI=1S/C17H15N5O/c18-9-12-2-1-3-13(8-12)14-10-19-16-15(14)17(21-11-20-16)22-4-6-23-7-5-22/h1-3,8,10-11H,4-7H2,(H,19,20,21)
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM50059301
PNG
(CHEMBL3393346 | US9156845, 5)
Show SMILES CN(C)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12
Show InChI InChI=1S/C15H13N5/c1-20(2)15-13-12(8-17-14(13)18-9-19-15)11-5-3-4-10(6-11)7-16/h3-6,8-9H,1-2H3,(H,17,18,19)
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n/an/a 15n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM50059281
PNG
(CHEMBL3393444 | US9156845, 6)
Show SMILES C[C@H]1CN(CCO1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12
Show InChI InChI=1S/C18H17N5O/c1-12-10-23(5-6-24-12)18-16-15(9-20-17(16)21-11-22-18)14-4-2-3-13(7-14)8-19/h2-4,7,9,11-12H,5-6,10H2,1H3,(H,20,21,22)/t12-/m0/s1
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185571
PNG
(US9156845, 7)
Show SMILES C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3cccc(CO)c3)c12
Show InChI InChI=1S/C19H22N4O/c1-13-4-3-7-23(10-13)19-17-16(9-20-18(17)21-12-22-19)15-6-2-5-14(8-15)11-24/h2,5-6,8-9,12-13,24H,3-4,7,10-11H2,1H3,(H,20,21,22)/t13-/m0/s1
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185572
PNG
(US9156845, 8)
Show SMILES C1CN(CCO1)c1ncnc2[nH]cc(-c3cn[nH]c3)c12
Show InChI InChI=1S/C13H14N6O/c1-3-20-4-2-19(1)13-11-10(9-5-17-18-6-9)7-14-12(11)15-8-16-13/h5-8H,1-4H2,(H,17,18)(H,14,15,16)
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185573
PNG
(US9156845, 9)
Show SMILES Cc1nc(N2CCOCC2)c2c(c[nH]c2n1)-c1cccc(c1)C#N
Show InChI InChI=1S/C18H17N5O/c1-12-21-17-16(18(22-12)23-5-7-24-8-6-23)15(11-20-17)14-4-2-3-13(9-14)10-19/h2-4,9,11H,5-8H2,1H3,(H,20,21,22)
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185574
PNG
(US9156845, 10)
Show SMILES CN(C)c1ncnc2[nH]cc(-c3cccc(CO)c3)c12
Show InChI InChI=1S/C15H16N4O/c1-19(2)15-13-12(7-16-14(13)17-9-18-15)11-5-3-4-10(6-11)8-20/h3-7,9,20H,8H2,1-2H3,(H,16,17,18)
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185370
PNG
(US9156845, 11)
Show SMILES CC1(C)CCCN(C1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12
Show InChI InChI=1S/C20H21N5/c1-20(2)7-4-8-25(12-20)19-17-16(11-22-18(17)23-13-24-19)15-6-3-5-14(9-15)10-21/h3,5-6,9,11,13H,4,7-8,12H2,1-2H3,(H,22,23,24)
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM50059353
PNG
(CHEMBL3393343 | US9156845, 12)
Show SMILES N#Cc1cccc(c1)-c1c[nH]c2ncnc(N3CCCCC3)c12
Show InChI InChI=1S/C18H17N5/c19-10-13-5-4-6-14(9-13)15-11-20-17-16(15)18(22-12-21-17)23-7-2-1-3-8-23/h4-6,9,11-12H,1-3,7-8H2,(H,20,21,22)
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185371
PNG
(US9156845, 13)
Show SMILES NC(=O)C1CCCN(C1)c1ncnc2[nH]cc(-c3ccccc3)c12
Show InChI InChI=1S/C18H19N5O/c19-16(24)13-7-4-8-23(10-13)18-15-14(12-5-2-1-3-6-12)9-20-17(15)21-11-22-18/h1-3,5-6,9,11,13H,4,7-8,10H2,(H2,19,24)(H,20,21,22)
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185372
PNG
(US9156845, 14)
Show SMILES O[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12
Show InChI InChI=1S/C18H17N5O/c19-8-12-3-1-4-13(7-12)15-9-20-17-16(15)18(22-11-21-17)23-6-2-5-14(24)10-23/h1,3-4,7,9,11,14,24H,2,5-6,10H2,(H,20,21,22)/t14-/m0/s1
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185373
PNG
(US9156845, 15)
Show SMILES C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3ccccc3)c12
Show InChI InChI=1S/C18H20N4/c1-13-6-5-9-22(11-13)18-16-15(14-7-3-2-4-8-14)10-19-17(16)20-12-21-18/h2-4,7-8,10,12-13H,5-6,9,11H2,1H3,(H,19,20,21)/t13-/m0/s1
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM50059259
PNG
(CHEMBL3393341 | US9156845, 16)
Show SMILES C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12
Show InChI InChI=1S/C19H19N5/c1-13-4-3-7-24(11-13)19-17-16(10-21-18(17)22-12-23-19)15-6-2-5-14(8-15)9-20/h2,5-6,8,10,12-13H,3-4,7,11H2,1H3,(H,21,22,23)/t13-/m0/s1
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US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185374
PNG
(US9156845, 17)
Show SMILES C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3cnn(C)c3)c12
Show InChI InChI=1S/C16H20N6/c1-11-4-3-5-22(8-11)16-14-13(12-6-20-21(2)9-12)7-17-15(14)18-10-19-16/h6-7,9-11H,3-5,8H2,1-2H3,(H,17,18,19)/t11-/m0/s1
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US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185375
PNG
(US9156845, 18)
Show SMILES C1CCN(C1)c1ncnc2[nH]cc(-c3ccccc3)c12
Show InChI InChI=1S/C16H16N4/c1-2-6-12(7-3-1)13-10-17-15-14(13)16(19-11-18-15)20-8-4-5-9-20/h1-3,6-7,10-11H,4-5,8-9H2,(H,17,18,19)
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185376
PNG
(US9156845, 19)
Show SMILES OCC1CCN(CC1)c1ncnc2[nH]cc(-c3ccccc3)c12
Show InChI InChI=1S/C18H20N4O/c23-11-13-6-8-22(9-7-13)18-16-15(14-4-2-1-3-5-14)10-19-17(16)20-12-21-18/h1-5,10,12-13,23H,6-9,11H2,(H,19,20,21)
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US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185377
PNG
(US9156845, 20)
Show SMILES OCc1cccc(c1)-c1c[nH]c2ncnc(N3CCCC(C3)[N+]#[C-])c12
Show InChI InChI=1S/C19H19N5O/c1-20-15-6-3-7-24(10-15)19-17-16(9-21-18(17)22-12-23-19)14-5-2-4-13(8-14)11-25/h2,4-5,8-9,12,15,25H,3,6-7,10-11H2,(H,21,22,23)
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185378
PNG
(US9156845, 21)
Show SMILES [C-]#[N+]C1CCCN(C1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12
Show InChI InChI=1S/C19H16N6/c1-21-15-6-3-7-25(11-15)19-17-16(10-22-18(17)23-12-24-19)14-5-2-4-13(8-14)9-20/h2,4-5,8,10,12,15H,3,6-7,11H2,(H,22,23,24)
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185379
PNG
(US9156845, 22)
Show SMILES C[C@H]1C[C@@H](C)CN(C1)c1ncnc2[nH]cc(-c3cnn(C)c3)c12
Show InChI InChI=1S/C17H22N6/c1-11-4-12(2)8-23(7-11)17-15-14(13-5-21-22(3)9-13)6-18-16(15)19-10-20-17/h5-6,9-12H,4,7-8H2,1-3H3,(H,18,19,20)/t11-,12+
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US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185380
PNG
(US9156845, 23)
Show SMILES COc1ccc(cc1-c1c[nH]c2ncnc(N3CCCC(C)C3)c12)[N+]#[C-]
Show InChI InChI=1S/C20H21N5O/c1-13-5-4-8-25(11-13)20-18-16(10-22-19(18)23-12-24-20)15-9-14(21-2)6-7-17(15)26-3/h6-7,9-10,12-13H,4-5,8,11H2,1,3H3,(H,22,23,24)
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Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185381
PNG
(US9156845, 24)
Show SMILES COc1ccc(cc1-c1c[nH]c2ncnc(N(C)C)c12)[N+]#[C-]
Show InChI InChI=1S/C16H15N5O/c1-17-10-5-6-13(22-4)11(7-10)12-8-18-15-14(12)16(21(2)3)20-9-19-15/h5-9H,2-4H3,(H,18,19,20)
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Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185382
PNG
(US9156845, 25)
Show SMILES COc1ccc(Cl)cc1-c1c[nH]c2ncnc(N(C)C)c12
Show InChI InChI=1S/C15H15ClN4O/c1-20(2)15-13-11(7-17-14(13)18-8-19-15)10-6-9(16)4-5-12(10)21-3/h4-8H,1-3H3,(H,17,18,19)
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US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185383
PNG
(US9156845, 26)
Show SMILES N#Cc1cccc(c1)-c1c[nH]c2ncnc(N3CCC(CC3)c3ncc[nH]3)c12
Show InChI InChI=1S/C21H19N7/c22-11-14-2-1-3-16(10-14)17-12-25-20-18(17)21(27-13-26-20)28-8-4-15(5-9-28)19-23-6-7-24-19/h1-3,6-7,10,12-13,15H,4-5,8-9H2,(H,23,24)(H,25,26,27)
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US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM50059420
PNG
(CHEMBL3393352 | US9156845, 27)
Show SMILES COCC1CCCN(C1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12
Show InChI InChI=1S/C20H21N5O/c1-26-12-15-5-3-7-25(11-15)20-18-17(10-22-19(18)23-13-24-20)16-6-2-4-14(8-16)9-21/h2,4,6,8,10,13,15H,3,5,7,11-12H2,1H3,(H,22,23,24)
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Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185384
PNG
(US9156845, 28)
Show SMILES CN1CCC2(CC1)CN(CCO2)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12
Show InChI InChI=1S/C22H24N6O/c1-27-7-5-22(6-8-27)14-28(9-10-29-22)21-19-18(13-24-20(19)25-15-26-21)17-4-2-3-16(11-17)12-23/h2-4,11,13,15H,5-10,14H2,1H3,(H,24,25,26)
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Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM50059422
PNG
(CHEMBL3393350 | US9156845, 29)
Show SMILES COC1CCCN(C1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12
Show InChI InChI=1S/C19H19N5O/c1-25-15-6-3-7-24(11-15)19-17-16(10-21-18(17)22-12-23-19)14-5-2-4-13(8-14)9-20/h2,4-5,8,10,12,15H,3,6-7,11H2,1H3,(H,21,22,23)
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Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185385
PNG
(US9156845, 197 | US9156845, 30 | US9156845, 74)
Show SMILES COCC1CN(CCO1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12
Show InChI InChI=1S/C19H19N5O2/c1-25-11-15-10-24(5-6-26-15)19-17-16(9-21-18(17)22-12-23-19)14-4-2-3-13(7-14)8-20/h2-4,7,9,12,15H,5-6,10-11H2,1H3,(H,21,22,23)
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Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185386
PNG
(US9156845, 31)
Show SMILES CN(C)C(=O)CCNc1ncnc2[nH]cc(-c3cccc(c3)C#N)c12
Show InChI InChI=1S/C18H18N6O/c1-24(2)15(25)6-7-20-17-16-14(10-21-18(16)23-11-22-17)13-5-3-4-12(8-13)9-19/h3-5,8,10-11H,6-7H2,1-2H3,(H2,20,21,22,23)
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Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185387
PNG
(US9156845, 32)
Show SMILES FC1(F)CCN(CC1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12
Show InChI InChI=1S/C18H15F2N5/c19-18(20)4-6-25(7-5-18)17-15-14(10-22-16(15)23-11-24-17)13-3-1-2-12(8-13)9-21/h1-3,8,10-11H,4-7H2,(H,22,23,24)
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Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185388
PNG
(US9156845, 33 | US9156845, 33A)
Show SMILES FC1CCN(CC1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12
Show InChI InChI=1S/C18H16FN5/c19-14-4-6-24(7-5-14)18-16-15(10-21-17(16)22-11-23-18)13-3-1-2-12(8-13)9-20/h1-3,8,10-11,14H,4-7H2,(H,21,22,23)
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Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185388
PNG
(US9156845, 33 | US9156845, 33A)
Show SMILES FC1CCN(CC1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12
Show InChI InChI=1S/C18H16FN5/c19-14-4-6-24(7-5-14)18-16-15(10-21-17(16)22-11-23-18)13-3-1-2-12(8-13)9-20/h1-3,8,10-11,14H,4-7H2,(H,21,22,23)
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US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185390
PNG
(US9156845, 34)
Show SMILES N#Cc1cccc(c1)-c1c[nH]c2ncnc(N3CCC(CC3)c3cc[nH]n3)c12
Show InChI InChI=1S/C21H19N7/c22-11-14-2-1-3-16(10-14)17-12-23-20-19(17)21(25-13-24-20)28-8-5-15(6-9-28)18-4-7-26-27-18/h1-4,7,10,12-13,15H,5-6,8-9H2,(H,26,27)(H,23,24,25)
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185391
PNG
(US9156845, 35)
Show SMILES F[C@H]1CCN(C1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12
Show InChI InChI=1S/C17H14FN5/c18-13-4-5-23(9-13)17-15-14(8-20-16(15)21-10-22-17)12-3-1-2-11(6-12)7-19/h1-3,6,8,10,13H,4-5,9H2,(H,20,21,22)/t13-/m0/s1
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US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185392
PNG
(US9156845, 36 | US9156845, 76)
Show SMILES N#Cc1cccc(c1)-c1c[nH]c2ncnc(N3CCOC(C3)c3cc[nH]n3)c12
Show InChI InChI=1S/C20H17N7O/c21-9-13-2-1-3-14(8-13)15-10-22-19-18(15)20(24-12-23-19)27-6-7-28-17(11-27)16-4-5-25-26-16/h1-5,8,10,12,17H,6-7,11H2,(H,25,26)(H,22,23,24)
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185393
PNG
(US9156845, 37)
Show SMILES N#Cc1cccc(c1)-c1c[nH]c2ncnc(N3CCCC(C3)c3cc[nH]n3)c12
Show InChI InChI=1S/C21H19N7/c22-10-14-3-1-4-15(9-14)17-11-23-20-19(17)21(25-13-24-20)28-8-2-5-16(12-28)18-6-7-26-27-18/h1,3-4,6-7,9,11,13,16H,2,5,8,12H2,(H,26,27)(H,23,24,25)
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185394
PNG
(US9156845, 38)
Show SMILES N#Cc1cccc(c1)-c1c[nH]c2ncnc(N3CCCC(C3)c3ncc[nH]3)c12
Show InChI InChI=1S/C21H19N7/c22-10-14-3-1-4-15(9-14)17-11-25-20-18(17)21(27-13-26-20)28-8-2-5-16(12-28)19-23-6-7-24-19/h1,3-4,6-7,9,11,13,16H,2,5,8,12H2,(H,23,24)(H,25,26,27)
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185395
PNG
(US9156845, 39)
Show SMILES CN1CCCC(C1)Nc1ncnc2[nH]cc(-c3cccc(c3)C#N)c12
Show InChI InChI=1S/C19H20N6/c1-25-7-3-6-15(11-25)24-19-17-16(10-21-18(17)22-12-23-19)14-5-2-4-13(8-14)9-20/h2,4-5,8,10,12,15H,3,6-7,11H2,1H3,(H2,21,22,23,24)
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Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185396
PNG
(US9156845, 40)
Show SMILES O=C1CC2(CN1)CCCN(C2)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12
Show InChI InChI=1S/C21H20N6O/c22-9-14-3-1-4-15(7-14)16-10-23-19-18(16)20(26-13-25-19)27-6-2-5-21(12-27)8-17(28)24-11-21/h1,3-4,7,10,13H,2,5-6,8,11-12H2,(H,24,28)(H,23,25,26)
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US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185397
PNG
(US9156845, 41)
Show SMILES CC1CCCN(C1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12
Show InChI InChI=1S/C19H19N5/c1-13-4-3-7-24(11-13)19-17-16(10-21-18(17)22-12-23-19)15-6-2-5-14(8-15)9-20/h2,5-6,8,10,12-13H,3-4,7,11H2,1H3,(H,21,22,23)
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Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185398
PNG
(US9156845, 42)
Show SMILES N#Cc1cccc(c1)-c1c[nH]c2ncnc(NCCN3CCOCC3)c12
Show InChI InChI=1S/C19H20N6O/c20-11-14-2-1-3-15(10-14)16-12-22-19-17(16)18(23-13-24-19)21-4-5-25-6-8-26-9-7-25/h1-3,10,12-13H,4-9H2,(H2,21,22,23,24)
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Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185399
PNG
(US9156845, 43)
Show SMILES N#Cc1cccc(c1)-c1c[nH]c2ncnc(N3CCCC4(CCOC4)C3)c12
Show InChI InChI=1S/C21H21N5O/c22-10-15-3-1-4-16(9-15)17-11-23-19-18(17)20(25-14-24-19)26-7-2-5-21(12-26)6-8-27-13-21/h1,3-4,9,11,14H,2,5-8,12-13H2,(H,23,24,25)
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Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185400
PNG
(US9156845, 44)
Show SMILES CC(=O)NC1CCN(CC1)c1ncnc2[nH]cc(-c3cccc(c3)C#N)c12
Show InChI InChI=1S/C20H20N6O/c1-13(27)25-16-5-7-26(8-6-16)20-18-17(11-22-19(18)23-12-24-20)15-4-2-3-14(9-15)10-21/h2-4,9,11-12,16H,5-8H2,1H3,(H,25,27)(H,22,23,24)
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n/an/a 190n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185401
PNG
(US9156845, 45)
Show SMILES C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3ccc4[nH]ncc4c3)c12
Show InChI InChI=1S/C19H18N6/c1-12-3-2-6-25(10-12)19-17-15(9-20-18(17)21-11-22-19)13-4-5-16-14(7-13)8-23-24-16/h4-5,7-9,11-12H,2-3,6,10H2,1H3/b15-13+/t12-/m0/s1
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n/an/a 66n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185402
PNG
(US9156845, 46)
Show SMILES C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3cccc(c3)S(N)(=O)=O)c12
Show InChI InChI=1S/C18H21N5O2S/c1-12-4-3-7-23(10-12)18-16-15(9-20-17(16)21-11-22-18)13-5-2-6-14(8-13)26(19,24)25/h2,5-6,8-9,11-12H,3-4,7,10H2,1H3,(H2,19,24,25)(H,20,21,22)/t12-/m0/s1
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n/an/a 33n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185403
PNG
(US9156845, 47)
Show SMILES C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3ccccc3F)c12
Show InChI InChI=1S/C18H19FN4/c1-12-5-4-8-23(10-12)18-16-14(9-20-17(16)21-11-22-18)13-6-2-3-7-15(13)19/h2-3,6-7,9,11-12H,4-5,8,10H2,1H3,(H,20,21,22)/t12-/m0/s1
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n/an/a 122n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185404
PNG
(US9156845, 48)
Show SMILES C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3cccc4[nH]ncc34)c12
Show InChI InChI=1S/C19H18N6/c1-12-4-3-7-25(10-12)19-17-15(8-20-18(17)21-11-22-19)13-5-2-6-16-14(13)9-23-24-16/h2,5-6,8-9,11-12H,3-4,7,10H2,1H3/b15-13+/t12-/m0/s1
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n/an/a 14n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185405
PNG
(US9156845, 49)
Show SMILES C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3cnc(F)c(C)c3)c12
Show InChI InChI=1S/C18H20FN5/c1-11-4-3-5-24(9-11)18-15-14(8-21-17(15)22-10-23-18)13-6-12(2)16(19)20-7-13/h6-8,10-11H,3-5,9H2,1-2H3,(H,21,22,23)/t11-/m0/s1
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n/an/a 65n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
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