Compile Data Set for Download or QSAR

Found 977 hits Enz. Inhib. hit(s) with Target = 'Leukotriene A4 hydrolase'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24202 (2-{4-[2-(pyrrolidin-1-yl)ethoxy]phenoxy}-1H-1,3-be...) Show SMILES C(CN1CCCC1)Oc1ccc(Oc2nc3ccccc3[nH]2)cc1 Show InChI InChI=1S/C19H21N3O2/c1-2-6-18-17(5-1)20-19(21-18)24-16-9-7-15(8-10-16)23-14-13-22-11-3-4-12-22/h1-2,5-10H,3-4,11-14H2,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	84	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24203 (2-{4-[2-(piperidin-1-yl)ethoxy]phenoxy}-1,3-benzox...) Show SMILES C(CN1CCCCC1)Oc1ccc(Oc2nc3ccccc3o2)cc1 Show InChI InChI=1S/C20H22N2O3/c1-4-12-22(13-5-1)14-15-23-16-8-10-17(11-9-16)24-20-21-18-6-2-3-7-19(18)25-20/h2-3,6-11H,1,4-5,12-15H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24199 (2-{4-[2-(pyrrolidin-1-yl)ethoxy]phenoxy}-1,3-benzo...) Show SMILES C(CN1CCCC1)Oc1ccc(Oc2nc3ccccc3o2)cc1 Show InChI InChI=1S/C19H20N2O3/c1-2-6-18-17(5-1)20-19(24-18)23-16-9-7-15(8-10-16)22-14-13-21-11-3-4-12-21/h1-2,5-10H,3-4,11-14H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24225 (1-{2-[4-(1,3-benzothiazol-2-yloxy)phenyl]ethyl}pip...) Show SMILES NC(=O)C1CCN(CCc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C21H23N3O2S/c22-20(25)16-10-13-24(14-11-16)12-9-15-5-7-17(8-6-15)26-21-23-18-3-1-2-4-19(18)27-21/h1-8,16H,9-14H2,(H2,22,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24224 (1-{2-[4-(1,3-benzothiazol-2-yloxy)phenyl]ethyl}pip...) Show SMILES OC1CCN(CCc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C20H22N2O2S/c23-16-10-13-22(14-11-16)12-9-15-5-7-17(8-6-15)24-20-21-18-3-1-2-4-19(18)25-20/h1-8,16,23H,9-14H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24223 (2-{4-[2-(piperidin-1-yl)ethyl]phenoxy}-1,3-benzoth...) Show SMILES C(Cc1ccc(Oc2nc3ccccc3s2)cc1)N1CCCCC1 Show InChI InChI=1S/C20H22N2OS/c1-4-13-22(14-5-1)15-12-16-8-10-17(11-9-16)23-20-21-18-6-2-3-7-19(18)24-20/h2-3,6-11H,1,4-5,12-15H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24222 (3-(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl...) Show SMILES O=C1OCCN1C1CCN(CCOc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C23H25N3O4S/c27-23-26(14-16-29-23)17-9-11-25(12-10-17)13-15-28-18-5-7-19(8-6-18)30-22-24-20-3-1-2-4-21(20)31-22/h1-8,17H,9-16H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24221 (1-(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl...) Show SMILES O=C1CCCCN1C1CCN(CCOc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C25H29N3O3S/c29-24-7-3-4-14-28(24)19-12-15-27(16-13-19)17-18-30-20-8-10-21(11-9-20)31-25-26-22-5-1-2-6-23(22)32-25/h1-2,5-6,8-11,19H,3-4,7,12-18H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24220 (1-(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl...) Show SMILES O=C1CCCN1C1CCN(CCOc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C24H27N3O3S/c28-23-6-3-13-27(23)18-11-14-26(15-12-18)16-17-29-19-7-9-20(10-8-19)30-24-25-21-4-1-2-5-22(21)31-24/h1-2,4-5,7-10,18H,3,6,11-17H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24219 (1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl}pi...) Show SMILES NC1CCN(CCOc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C20H23N3O2S/c21-15-9-11-23(12-10-15)13-14-24-16-5-7-17(8-6-16)25-20-22-18-3-1-2-4-19(18)26-20/h1-8,15H,9-14,21H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	66	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24218 (1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl}pi...) Show SMILES NC(=O)C1CCN(CCOc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C21H23N3O3S/c22-20(25)15-9-11-24(12-10-15)13-14-26-16-5-7-17(8-6-16)27-21-23-18-3-1-2-4-19(18)28-21/h1-8,15H,9-14H2,(H2,22,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24217 (1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl}-4...) Show SMILES OC1(CCN(CCOc2ccc(Oc3nc4ccccc4s3)cc2)CC1)c1ccccc1 Show InChI InChI=1S/C26H26N2O3S/c29-26(20-6-2-1-3-7-20)14-16-28(17-15-26)18-19-30-21-10-12-22(13-11-21)31-25-27-23-8-4-5-9-24(23)32-25/h1-13,29H,14-19H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	66	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24216 (1-{2-[4-(1,3-benzoxazol-2-yloxy)phenoxy]ethyl}-4-p...) Show SMILES OC1(CCN(CCOc2ccc(Oc3nc4ccccc4o3)cc2)CC1)c1ccccc1 Show InChI InChI=1S/C26H26N2O4/c29-26(20-6-2-1-3-7-20)14-16-28(17-15-26)18-19-30-21-10-12-22(13-11-21)31-25-27-23-8-4-5-9-24(23)32-25/h1-13,29H,14-19H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24215 ((1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl}p...) Show SMILES OCC1CCN(CCOc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C21H24N2O3S/c24-15-16-9-11-23(12-10-16)13-14-25-17-5-7-18(8-6-17)26-21-22-19-3-1-2-4-20(19)27-21/h1-8,16,24H,9-15H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24214 ((1-{2-[4-(1,3-benzoxazol-2-yloxy)phenoxy]ethyl}pip...) Show SMILES OCC1CCN(CCOc2ccc(Oc3nc4ccccc4o3)cc2)CC1 Show InChI InChI=1S/C21H24N2O4/c24-15-16-9-11-23(12-10-16)13-14-25-17-5-7-18(8-6-17)26-21-22-19-3-1-2-4-20(19)27-21/h1-8,16,24H,9-15H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24213 (1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl}pi...) Show SMILES OC1CCN(CCOc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C20H22N2O3S/c23-15-9-11-22(12-10-15)13-14-24-16-5-7-17(8-6-16)25-20-21-18-3-1-2-4-19(18)26-20/h1-8,15,23H,9-14H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24212 (1-{2-[4-(1,3-benzoxazol-2-yloxy)phenoxy]ethyl}pipe...) Show SMILES OC1CCN(CCOc2ccc(Oc3nc4ccccc4o3)cc2)CC1 Show InChI InChI=1S/C20H22N2O4/c23-15-9-11-22(12-10-15)13-14-24-16-5-7-17(8-6-16)25-20-21-18-3-1-2-4-19(18)26-20/h1-8,15,23H,9-14H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24211 (4-{2-[4-(1H-1,3-benzodiazol-2-yloxy)phenoxy]ethyl}...) Show SMILES C(CN1CCOCC1)Oc1ccc(Oc2nc3ccccc3[nH]2)cc1 Show InChI InChI=1S/C19H21N3O3/c1-2-4-18-17(3-1)20-19(21-18)25-16-7-5-15(6-8-16)24-14-11-22-9-12-23-13-10-22/h1-8H,9-14H2,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24210 (4-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl}mo...) Show SMILES C(CN1CCOCC1)Oc1ccc(Oc2nc3ccccc3s2)cc1 Show InChI InChI=1S/C19H20N2O3S/c1-2-4-18-17(3-1)20-19(25-18)24-16-7-5-15(6-8-16)23-14-11-21-9-12-22-13-10-21/h1-8H,9-14H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24209 (2-{4-[2-(morpholin-4-yl)ethoxy]phenoxy}-1,3-benzox...) Show SMILES C(CN1CCOCC1)Oc1ccc(Oc2nc3ccccc3o2)cc1 Show InChI InChI=1S/C19H20N2O4/c1-2-4-18-17(3-1)20-19(25-18)24-16-7-5-15(6-8-16)23-14-11-21-9-12-22-13-10-21/h1-8H,9-14H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	58	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24208 (2-{4-[2-(azepan-1-yl)ethoxy]phenoxy}-1H-1,3-benzod...) Show SMILES C(CN1CCCCCC1)Oc1ccc(Oc2nc3ccccc3[nH]2)cc1 Show InChI InChI=1S/C21H25N3O2/c1-2-6-14-24(13-5-1)15-16-25-17-9-11-18(12-10-17)26-21-22-19-7-3-4-8-20(19)23-21/h3-4,7-12H,1-2,5-6,13-16H2,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24207 (2-{4-[2-(azepan-1-yl)ethoxy]phenoxy}-1,3-benzothia...) Show SMILES C(CN1CCCCCC1)Oc1ccc(Oc2nc3ccccc3s2)cc1 Show InChI InChI=1S/C21H24N2O2S/c1-2-6-14-23(13-5-1)15-16-24-17-9-11-18(12-10-17)25-21-22-19-7-3-4-8-20(19)26-21/h3-4,7-12H,1-2,5-6,13-16H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	66	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24206 (2-{4-[2-(azepan-1-yl)ethoxy]phenoxy}-1,3-benzoxazo...) Show SMILES C(CN1CCCCCC1)Oc1ccc(Oc2nc3ccccc3o2)cc1 Show InChI InChI=1S/C21H24N2O3/c1-2-6-14-23(13-5-1)15-16-24-17-9-11-18(12-10-17)25-21-22-19-7-3-4-8-20(19)26-21/h3-4,7-12H,1-2,5-6,13-16H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24205 (2-{4-[2-(piperidin-1-yl)ethoxy]phenoxy}-1H-1,3-ben...) Show SMILES C(CN1CCCCC1)Oc1ccc(Oc2nc3ccccc3[nH]2)cc1 Show InChI InChI=1S/C20H23N3O2/c1-4-12-23(13-5-1)14-15-24-16-8-10-17(11-9-16)25-20-21-18-6-2-3-7-19(18)22-20/h2-3,6-11H,1,4-5,12-15H2,(H,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24204 (2-{4-[2-(piperidin-1-yl)ethoxy]phenoxy}-1,3-benzot...) Show SMILES C(CN1CCCCC1)Oc1ccc(Oc2nc3ccccc3s2)cc1 Show InChI InChI=1S/C20H22N2O2S/c1-4-12-22(13-5-1)14-15-23-16-8-10-17(11-9-16)24-20-21-18-6-2-3-7-19(18)25-20/h2-3,6-11H,1,4-5,12-15H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	54	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24201 (2-{4-[2-(pyrrolidin-1-yl)ethoxy]phenoxy}-1,3-benzo...) Show SMILES C(CN1CCCC1)Oc1ccc(Oc2nc3ccccc3s2)cc1 Show InChI InChI=1S/C19H20N2O2S/c1-2-6-18-17(5-1)20-19(24-18)23-16-9-7-15(8-10-16)22-14-13-21-11-3-4-12-21/h1-2,5-10H,3-4,11-14H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	7.4	22
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24269 ((2S)-2-amino-N-(6-phenoxypyridin-3-yl)pentanediami...) Show SMILES N[C@@H](CCC(=O)Nc1ccc(Oc2ccccc2)nc1)C(N)=O Show InChI InChI=1S/C16H18N4O3/c17-13(16(18)22)7-8-14(21)20-11-6-9-15(19-10-11)23-12-4-2-1-3-5-12/h1-6,9-10,13H,7-8,17H2,(H2,18,22)(H,20,21)/t13-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	7.5	22
Berlex Biosciences					Assay Description Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...				Bioorg Med Chem 16: 4963-83 (2008) Article DOI: 10.1016/j.bmc.2008.03.042 BindingDB Entry DOI: 10.7270/Q2BP013C
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24270 ((2S)-2-amino-4-[(4-phenoxyphenyl)carbamoyl]butanoi...) Show SMILES N[C@@H](CCC(=O)Nc1ccc(Oc2ccccc2)cc1)C(O)=O Show InChI InChI=1S/C17H18N2O4/c18-15(17(21)22)10-11-16(20)19-12-6-8-14(9-7-12)23-13-4-2-1-3-5-13/h1-9,15H,10-11,18H2,(H,19,20)(H,21,22)/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	7.5	22
Berlex Biosciences					Assay Description Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...				Bioorg Med Chem 16: 4963-83 (2008) Article DOI: 10.1016/j.bmc.2008.03.042 BindingDB Entry DOI: 10.7270/Q2BP013C
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24271 ((2S)-2-amino-N-(4-benzylphenyl)pentanediamide | Mo...) Show SMILES N[C@@H](CCC(=O)Nc1ccc(Cc2ccccc2)cc1)C(N)=O Show InChI InChI=1S/C18H21N3O2/c19-16(18(20)23)10-11-17(22)21-15-8-6-14(7-9-15)12-13-4-2-1-3-5-13/h1-9,16H,10-12,19H2,(H2,20,23)(H,21,22)/t16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	7.5	22
Berlex Biosciences					Assay Description Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...				Bioorg Med Chem 16: 4963-83 (2008) Article DOI: 10.1016/j.bmc.2008.03.042 BindingDB Entry DOI: 10.7270/Q2BP013C
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24268 (Modified amino acid analog, 8c | methyl (2S)-2-ami...) Show SMILES COC(=O)[C@@H](N)CCC(=O)Nc1cccc(OCc2ccccc2)c1 Show InChI InChI=1S/C19H22N2O4/c1-24-19(23)17(20)10-11-18(22)21-15-8-5-9-16(12-15)25-13-14-6-3-2-4-7-14/h2-9,12,17H,10-11,13,20H2,1H3,(H,21,22)/t17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	730	n/a	n/a	n/a	n/a	7.5	22
Berlex Biosciences					Assay Description Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...				Bioorg Med Chem 16: 4963-83 (2008) Article DOI: 10.1016/j.bmc.2008.03.042 BindingDB Entry DOI: 10.7270/Q2BP013C
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24267 ((2S)-2-amino-N-[4-(1H-pyrrol-1-yl)phenyl]pentanedi...) Show SMILES N[C@@H](CCC(=O)Nc1ccc(cc1)-n1cccc1)C(N)=O Show InChI InChI=1S/C15H18N4O2/c16-13(15(17)21)7-8-14(20)18-11-3-5-12(6-4-11)19-9-1-2-10-19/h1-6,9-10,13H,7-8,16H2,(H2,17,21)(H,18,20)/t13-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.70E+3	n/a	n/a	n/a	n/a	7.5	22
Berlex Biosciences					Assay Description Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...				Bioorg Med Chem 16: 4963-83 (2008) Article DOI: 10.1016/j.bmc.2008.03.042 BindingDB Entry DOI: 10.7270/Q2BP013C
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24266 ((2S)-2-amino-N-phenylpentanediamide | Modified ami...) Show SMILES N[C@@H](CCC(=O)Nc1ccccc1)C(N)=O Show InChI InChI=1S/C11H15N3O2/c12-9(11(13)16)6-7-10(15)14-8-4-2-1-3-5-8/h1-5,9H,6-7,12H2,(H2,13,16)(H,14,15)/t9-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.80E+4	n/a	n/a	n/a	n/a	7.5	22
Berlex Biosciences					Assay Description Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...				Bioorg Med Chem 16: 4963-83 (2008) Article DOI: 10.1016/j.bmc.2008.03.042 BindingDB Entry DOI: 10.7270/Q2BP013C
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24265 (Modified amino acid analog, 7c | N-[4-(benzyloxy)p...) Show SMILES CN(C)CCCC(=O)Nc1ccc(OCc2ccccc2)cc1 Show InChI InChI=1S/C19H24N2O2/c1-21(2)14-6-9-19(22)20-17-10-12-18(13-11-17)23-15-16-7-4-3-5-8-16/h3-5,7-8,10-13H,6,9,14-15H2,1-2H3,(H,20,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.40E+3	n/a	n/a	n/a	n/a	7.5	22
Berlex Biosciences					Assay Description Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...				Bioorg Med Chem 16: 4963-83 (2008) Article DOI: 10.1016/j.bmc.2008.03.042 BindingDB Entry DOI: 10.7270/Q2BP013C
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24264 (Modified amino acid analog, 7b | N-[4-(benzyloxy)p...) Show SMILES CNCCCC(=O)Nc1ccc(OCc2ccccc2)cc1 Show InChI InChI=1S/C18H22N2O2/c1-19-13-5-8-18(21)20-16-9-11-17(12-10-16)22-14-15-6-3-2-4-7-15/h2-4,6-7,9-12,19H,5,8,13-14H2,1H3,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	7.5	22
Berlex Biosciences					Assay Description Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...				Bioorg Med Chem 16: 4963-83 (2008) Article DOI: 10.1016/j.bmc.2008.03.042 BindingDB Entry DOI: 10.7270/Q2BP013C
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24263 (4-amino-N-[4-(benzyloxy)phenyl]butanamide | Modifi...) Show SMILES NCCCC(=O)Nc1ccc(OCc2ccccc2)cc1 Show InChI InChI=1S/C17H20N2O2/c18-12-4-7-17(20)19-15-8-10-16(11-9-15)21-13-14-5-2-1-3-6-14/h1-3,5-6,8-11H,4,7,12-13,18H2,(H,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	61	n/a	n/a	n/a	n/a	7.5	22
Berlex Biosciences					Assay Description Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...				Bioorg Med Chem 16: 4963-83 (2008) Article DOI: 10.1016/j.bmc.2008.03.042 BindingDB Entry DOI: 10.7270/Q2BP013C
					More data for this Ligand-Target Pair				3D Structure (crystal)
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24262 ((2S)-2-amino-N-[4-(benzyloxy)phenyl]-N'-hydroxypen...) Show SMILES N[C@@H](CCC(=O)Nc1ccc(OCc2ccccc2)cc1)C(=O)NO Show InChI InChI=1S/C18H21N3O4/c19-16(18(23)21-24)10-11-17(22)20-14-6-8-15(9-7-14)25-12-13-4-2-1-3-5-13/h1-9,16,24H,10-12,19H2,(H,20,22)(H,21,23)/t16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	7.5	22
Berlex Biosciences					Assay Description Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...				Bioorg Med Chem 16: 4963-83 (2008) Article DOI: 10.1016/j.bmc.2008.03.042 BindingDB Entry DOI: 10.7270/Q2BP013C
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24261 ((2S)-2-amino-N-[4-(benzyloxy)phenyl]pentanediamide...) Show SMILES N[C@@H](CCC(=O)Nc1ccc(OCc2ccccc2)cc1)C(N)=O Show InChI InChI=1S/C18H21N3O3/c19-16(18(20)23)10-11-17(22)21-14-6-8-15(9-7-14)24-12-13-4-2-1-3-5-13/h1-9,16H,10-12,19H2,(H2,20,23)(H,21,22)/t16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	7.5	22
Berlex Biosciences					Assay Description Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...				Bioorg Med Chem 16: 4963-83 (2008) Article DOI: 10.1016/j.bmc.2008.03.042 BindingDB Entry DOI: 10.7270/Q2BP013C
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24260 (Modified amino acid analog, 6b | tert-butyl (2S)-2...) Show SMILES CC(C)(C)OC(=O)[C@@H](N)CCC(=O)Nc1ccc(OCc2ccccc2)cc1 Show InChI InChI=1S/C22H28N2O4/c1-22(2,3)28-21(26)19(23)13-14-20(25)24-17-9-11-18(12-10-17)27-15-16-7-5-4-6-8-16/h4-12,19H,13-15,23H2,1-3H3,(H,24,25)/t19-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	7.5	22
Berlex Biosciences					Assay Description Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...				Bioorg Med Chem 16: 4963-83 (2008) Article DOI: 10.1016/j.bmc.2008.03.042 BindingDB Entry DOI: 10.7270/Q2BP013C
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24259 (Modified amino acid analog, 6a | methyl (2S)-2-ami...) Show SMILES COC(=O)[C@@H](N)CCC(=O)Nc1ccc(OCc2ccccc2)cc1 Show InChI InChI=1S/C19H22N2O4/c1-24-19(23)17(20)11-12-18(22)21-15-7-9-16(10-8-15)25-13-14-5-3-2-4-6-14/h2-10,17H,11-13,20H2,1H3,(H,21,22)/t17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	39	n/a	n/a	n/a	n/a	7.5	22
Berlex Biosciences					Assay Description Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...				Bioorg Med Chem 16: 4963-83 (2008) Article DOI: 10.1016/j.bmc.2008.03.042 BindingDB Entry DOI: 10.7270/Q2BP013C
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24258 (4-{[4-(benzyloxy)phenyl]carbamoyl}butanoic acid | ...) Show SMILES OC(=O)CCCC(=O)Nc1ccc(OCc2ccccc2)cc1 Show InChI InChI=1S/C18H19NO4/c20-17(7-4-8-18(21)22)19-15-9-11-16(12-10-15)23-13-14-5-2-1-3-6-14/h1-3,5-6,9-12H,4,7-8,13H2,(H,19,20)(H,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.80E+4	n/a	n/a	n/a	n/a	7.5	22
Berlex Biosciences					Assay Description Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...				Bioorg Med Chem 16: 4963-83 (2008) Article DOI: 10.1016/j.bmc.2008.03.042 BindingDB Entry DOI: 10.7270/Q2BP013C
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24257 ((2R)-2-amino-4-{[4-(benzyloxy)phenyl]carbamoyl}but...) Show SMILES N[C@H](CCC(=O)Nc1ccc(OCc2ccccc2)cc1)C(O)=O Show InChI InChI=1S/C18H20N2O4/c19-16(18(22)23)10-11-17(21)20-14-6-8-15(9-7-14)24-12-13-4-2-1-3-5-13/h1-9,16H,10-12,19H2,(H,20,21)(H,22,23)/t16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	7.5	22
Berlex Biosciences					Assay Description Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...				Bioorg Med Chem 16: 4963-83 (2008) Article DOI: 10.1016/j.bmc.2008.03.042 BindingDB Entry DOI: 10.7270/Q2BP013C
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24256 ((2S)-2-amino-4-{[4-(benzyloxy)phenyl]carbamoyl}but...) Show SMILES N[C@@H](CCC(=O)Nc1ccc(OCc2ccccc2)cc1)C(O)=O Show InChI InChI=1S/C18H20N2O4/c19-16(18(22)23)10-11-17(21)20-14-6-8-15(9-7-14)24-12-13-4-2-1-3-5-13/h1-9,16H,10-12,19H2,(H,20,21)(H,22,23)/t16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	7.5	22
Berlex Biosciences					Assay Description Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...				Bioorg Med Chem 16: 4963-83 (2008) Article DOI: 10.1016/j.bmc.2008.03.042 BindingDB Entry DOI: 10.7270/Q2BP013C
					More data for this Ligand-Target Pair				3D Structure (crystal)
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24255 ((2S)-2-amino-3-{[4-(benzyloxy)phenyl]carbamoyl}pro...) Show SMILES N[C@@H](CC(=O)Nc1ccc(OCc2ccccc2)cc1)C(O)=O Show InChI InChI=1S/C17H18N2O4/c18-15(17(21)22)10-16(20)19-13-6-8-14(9-7-13)23-11-12-4-2-1-3-5-12/h1-9,15H,10-11,18H2,(H,19,20)(H,21,22)/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	7.5	22
Berlex Biosciences					Assay Description Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...				Bioorg Med Chem 16: 4963-83 (2008) Article DOI: 10.1016/j.bmc.2008.03.042 BindingDB Entry DOI: 10.7270/Q2BP013C
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24254 ((3R)-3-amino-3-{[4-(benzyloxy)phenyl]carbamoyl}pro...) Show SMILES N[C@H](CC(O)=O)C(=O)Nc1ccc(OCc2ccccc2)cc1 Show InChI InChI=1S/C17H18N2O4/c18-15(10-16(20)21)17(22)19-13-6-8-14(9-7-13)23-11-12-4-2-1-3-5-12/h1-9,15H,10-11,18H2,(H,19,22)(H,20,21)/t15-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.30E+3	n/a	n/a	n/a	n/a	7.5	22
Berlex Biosciences					Assay Description Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...				Bioorg Med Chem 16: 4963-83 (2008) Article DOI: 10.1016/j.bmc.2008.03.042 BindingDB Entry DOI: 10.7270/Q2BP013C
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24253 ((4R)-4-amino-4-{[4-(benzyloxy)phenyl]carbamoyl}but...) Show SMILES N[C@H](CCC(O)=O)C(=O)Nc1ccc(OCc2ccccc2)cc1 Show InChI InChI=1S/C18H20N2O4/c19-16(10-11-17(21)22)18(23)20-14-6-8-15(9-7-14)24-12-13-4-2-1-3-5-13/h1-9,16H,10-12,19H2,(H,20,23)(H,21,22)/t16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.20E+3	n/a	n/a	n/a	n/a	7.5	22
Berlex Biosciences					Assay Description Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...				Bioorg Med Chem 16: 4963-83 (2008) Article DOI: 10.1016/j.bmc.2008.03.042 BindingDB Entry DOI: 10.7270/Q2BP013C
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24252 ((3S)-3-amino-3-{[4-(benzyloxy)phenyl]carbamoyl}pro...) Show SMILES N[C@@H](CC(O)=O)C(=O)Nc1ccc(OCc2ccccc2)cc1 Show InChI InChI=1S/C17H18N2O4/c18-15(10-16(20)21)17(22)19-13-6-8-14(9-7-13)23-11-12-4-2-1-3-5-12/h1-9,15H,10-11,18H2,(H,19,22)(H,20,21)/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	5.40E+3	n/a	n/a	n/a	n/a	7.5	22
Berlex Biosciences					Assay Description Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...				Bioorg Med Chem 16: 4963-83 (2008) Article DOI: 10.1016/j.bmc.2008.03.042 BindingDB Entry DOI: 10.7270/Q2BP013C
					More data for this Ligand-Target Pair				3D Structure (crystal)
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24251 ((4S)-4-amino-4-{[4-(benzyloxy)phenyl]carbamoyl}but...) Show SMILES N[C@@H](CCC(O)=O)C(=O)Nc1ccc(OCc2ccccc2)cc1 Show InChI InChI=1S/C18H20N2O4/c19-16(10-11-17(21)22)18(23)20-14-6-8-15(9-7-14)24-12-13-4-2-1-3-5-13/h1-9,16H,10-12,19H2,(H,20,23)(H,21,22)/t16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	680	n/a	n/a	n/a	n/a	7.5	22
Berlex Biosciences					Assay Description Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...				Bioorg Med Chem 16: 4963-83 (2008) Article DOI: 10.1016/j.bmc.2008.03.042 BindingDB Entry DOI: 10.7270/Q2BP013C
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24250 ((2S)-2,6-diamino-N-[4-(benzyloxy)phenyl]hexanamide...) Show SMILES NCCCC[C@H](N)C(=O)Nc1ccc(OCc2ccccc2)cc1 Show InChI InChI=1S/C19H25N3O2/c20-13-5-4-8-18(21)19(23)22-16-9-11-17(12-10-16)24-14-15-6-2-1-3-7-15/h1-3,6-7,9-12,18H,4-5,8,13-14,20-21H2,(H,22,23)/t18-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.80E+3	n/a	n/a	n/a	n/a	7.5	22
Berlex Biosciences					Assay Description Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...				Bioorg Med Chem 16: 4963-83 (2008) Article DOI: 10.1016/j.bmc.2008.03.042 BindingDB Entry DOI: 10.7270/Q2BP013C
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24249 ((2S)-2-amino-N-[4-(benzyloxy)phenyl]-3-(1H-imidazo...) Show SMILES N[C@@H](Cc1cnc[nH]1)C(=O)Nc1ccc(OCc2ccccc2)cc1 Show InChI InChI=1S/C19H20N4O2/c20-18(10-16-11-21-13-22-16)19(24)23-15-6-8-17(9-7-15)25-12-14-4-2-1-3-5-14/h1-9,11,13,18H,10,12,20H2,(H,21,22)(H,23,24)/t18-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	7.5	22
Berlex Biosciences					Assay Description Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...				Bioorg Med Chem 16: 4963-83 (2008) Article DOI: 10.1016/j.bmc.2008.03.042 BindingDB Entry DOI: 10.7270/Q2BP013C
					More data for this Ligand-Target Pair
Leukotriene A4 hydrolase (Homo sapiens (human))	BDBM24248 ((2S)-2-amino-N-[4-(benzyloxy)phenyl]pentanediamide...) Show SMILES N[C@@H](CCC(N)=O)C(=O)Nc1ccc(OCc2ccccc2)cc1 Show InChI InChI=1S/C18H21N3O3/c19-16(10-11-17(20)22)18(23)21-14-6-8-15(9-7-14)24-12-13-4-2-1-3-5-13/h1-9,16H,10-12,19H2,(H2,20,22)(H,21,23)/t16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a	7.5	22
Berlex Biosciences					Assay Description Compound potency against the peptidase activity of LTA4 hydrolase was measured by inhibition of the hydrolysis of L-alanine-p-nitroanilide to L-alani...				Bioorg Med Chem 16: 4963-83 (2008) Article DOI: 10.1016/j.bmc.2008.03.042 BindingDB Entry DOI: 10.7270/Q2BP013C
					More data for this Ligand-Target Pair

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