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Found 871 hits Enz. Inhib. hit(s) with Target = 'Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM199180
PNG
(US9217012, 10)
Show SMILES CCc1ccc(cc1)C(=O)NCCCCC(NC(=O)C(Cc1ccc(cc1)C(F)(F)P(O)(O)=O)NC(=O)C(Cc1ccccc1)NC(=O)COC1CC(C)CCC1C(C)C)C(N)=O
Show InChI InChI=1S/C46H62F2N5O9P/c1-5-31-15-19-34(20-16-31)43(56)50-24-10-9-13-37(42(49)55)52-45(58)39(27-33-17-21-35(22-18-33)46(47,48)63(59,60)61)53-44(57)38(26-32-11-7-6-8-12-32)51-41(54)28-62-40-25-30(4)14-23-36(40)29(2)3/h6-8,11-12,15-22,29-30,36-40H,5,9-10,13-14,23-28H2,1-4H3,(H2,49,55)(H,50,56)(H,51,54)(H,52,58)(H,53,57)(H2,59,60,61)
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US Patent
>1.00E+3>-34.2n/an/an/an/an/a7.025



Indiana University Research and Technology Corporation

US Patent


Assay Description
PTP activity was assayed using p-nitrophenyl phosphate (pNPP) as a substrate in DMG buffer (50 mM DMG, pH 7.0, 1 mM EDTA, 150 mM NaCl, 2 mM DTT, 0.1 ...


US Patent US9217012 (2015)


BindingDB Entry DOI: 10.7270/Q2FX788H
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM50087856
PNG
(CHEMBL3426913)
Show SMILES CCCCC(Oc1cc(O)c(cc1C#Cc1ccccc1OC(F)(F)F)C(O)=O)C(=O)NC1CCCCC1
Show InChI InChI=1S/C28H30F3NO6/c1-2-3-12-24(26(34)32-20-10-5-4-6-11-20)37-25-17-22(33)21(27(35)36)16-19(25)15-14-18-9-7-8-13-23(18)38-28(29,30)31/h7-9,13,16-17,20,24,33H,2-6,10-12H2,1H3,(H,32,34)(H,35,36)
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n/an/a>5.00E+4n/an/an/an/a7.0n/a



Indiana University

Curated by ChEMBL


Assay Description
Inhibition of LMWPTP (unknown origin) using pNPP as substrate at pH 7 at 25 degC by spectrophotometric analysis


Bioorg Med Chem 23: 2798-809 (2015)


Article DOI: 10.1016/j.bmc.2015.03.066
BindingDB Entry DOI: 10.7270/Q2VD7168
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM50308158
PNG
(3-(1-(3-(Biphenyl-4-ylamino)-3-oxopropyl)-1H-1,2,3...)
Show SMILES Cn1c(c(-c2cn(CCC(=O)Nc3ccc(cc3)-c3ccccc3)nn2)c2cc(C(O)=O)c(O)cc12)-c1ccccc1
Show InChI InChI=1S/C33H27N5O4/c1-37-28-19-29(39)26(33(41)42)18-25(28)31(32(37)23-10-6-3-7-11-23)27-20-38(36-35-27)17-16-30(40)34-24-14-12-22(13-15-24)21-8-4-2-5-9-21/h2-15,18-20,39H,16-17H2,1H3,(H,34,40)(H,41,42)
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n/an/a 3.11E+4n/an/an/an/a7.0n/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of LMWPTP expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometry


J Med Chem 53: 2482-93 (2010)


Article DOI: 10.1021/jm901645u
BindingDB Entry DOI: 10.7270/Q2639PVD
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM50256796
PNG
(6,7-Dihydroxy-2-(4'-hydroxyphenyl)-3-[(1,1'-biphen...)
Show SMILES Oc1ccc(cc1)-c1oc2cc(O)c(O)cc2c(=O)c1Cc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C28H20O5/c29-21-12-10-20(11-13-21)28-23(27(32)22-15-24(30)25(31)16-26(22)33-28)14-17-6-8-19(9-7-17)18-4-2-1-3-5-18/h1-13,15-16,29-31H,14H2
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270n/an/an/an/an/an/an/an/a



University of Modena and R.E.

Curated by ChEMBL


Assay Description
Inhibition of human cloned LMW-PTP isoform 1 expressed in Escherichia coli TB1 by competitive inhibition assay


Bioorg Med Chem 17: 2658-72 (2009)


Article DOI: 10.1016/j.bmc.2009.02.060
BindingDB Entry DOI: 10.7270/Q2K0745F
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM50256796
PNG
(6,7-Dihydroxy-2-(4'-hydroxyphenyl)-3-[(1,1'-biphen...)
Show SMILES Oc1ccc(cc1)-c1oc2cc(O)c(O)cc2c(=O)c1Cc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C28H20O5/c29-21-12-10-20(11-13-21)28-23(27(32)22-15-24(30)25(31)16-26(22)33-28)14-17-6-8-19(9-7-17)18-4-2-1-3-5-18/h1-13,15-16,29-31H,14H2
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340n/an/an/an/an/an/an/an/a



University of Modena and R.E.

Curated by ChEMBL


Assay Description
Inhibition of human cloned LMW-PTP isoform 2 expressed in Escherichia coli TB1 by competitive inhibition assay


Bioorg Med Chem 17: 2658-72 (2009)


Article DOI: 10.1016/j.bmc.2009.02.060
BindingDB Entry DOI: 10.7270/Q2K0745F
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM50257418
PNG
(7-Hydroxy-2-(4'-hydroxyphenyl)-3-[(3'',4''-dihydro...)
Show SMILES Oc1ccc(cc1)-c1oc2cc(O)ccc2c(=O)c1Cc1ccc(cc1)-c1ccc(O)c(O)c1
Show InChI InChI=1S/C28H20O6/c29-20-8-5-18(6-9-20)28-23(27(33)22-11-10-21(30)15-26(22)34-28)13-16-1-3-17(4-2-16)19-7-12-24(31)25(32)14-19/h1-12,14-15,29-32H,13H2
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2.23E+3n/an/an/an/an/an/an/an/a



University of Modena and R.E.

Curated by ChEMBL


Assay Description
Inhibition of human cloned LMW-PTP isoform 1 expressed in Escherichia coli TB1 by mixed type inhibition assay


Bioorg Med Chem 17: 2658-72 (2009)


Article DOI: 10.1016/j.bmc.2009.02.060
BindingDB Entry DOI: 10.7270/Q2K0745F
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM50257294
PNG
(7-Hydroxy-2-(4'-hydroxyphenyl)-3-[(1,1'-biphenyl-4...)
Show SMILES Oc1ccc(cc1)-c1oc2cc(O)ccc2c(=O)c1Cc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C28H20O4/c29-22-12-10-21(11-13-22)28-25(27(31)24-15-14-23(30)17-26(24)32-28)16-18-6-8-20(9-7-18)19-4-2-1-3-5-19/h1-15,17,29-30H,16H2
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2.50E+3n/an/an/an/an/an/an/an/a



University of Modena and R.E.

Curated by ChEMBL


Assay Description
Inhibition of human cloned LMW-PTP isoform 1 expressed in Escherichia coli TB1 by mixed type inhibition assay


Bioorg Med Chem 17: 2658-72 (2009)


Article DOI: 10.1016/j.bmc.2009.02.060
BindingDB Entry DOI: 10.7270/Q2K0745F
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM50257418
PNG
(7-Hydroxy-2-(4'-hydroxyphenyl)-3-[(3'',4''-dihydro...)
Show SMILES Oc1ccc(cc1)-c1oc2cc(O)ccc2c(=O)c1Cc1ccc(cc1)-c1ccc(O)c(O)c1
Show InChI InChI=1S/C28H20O6/c29-20-8-5-18(6-9-20)28-23(27(33)22-11-10-21(30)15-26(22)34-28)13-16-1-3-17(4-2-16)19-7-12-24(31)25(32)14-19/h1-12,14-15,29-32H,13H2
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2.68E+3n/an/an/an/an/an/an/an/a



University of Modena and R.E.

Curated by ChEMBL


Assay Description
Inhibition of human cloned LMW-PTP isoform 2 expressed in Escherichia coli TB1 by mixed type inhibition assay


Bioorg Med Chem 17: 2658-72 (2009)


Article DOI: 10.1016/j.bmc.2009.02.060
BindingDB Entry DOI: 10.7270/Q2K0745F
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM50257294
PNG
(7-Hydroxy-2-(4'-hydroxyphenyl)-3-[(1,1'-biphenyl-4...)
Show SMILES Oc1ccc(cc1)-c1oc2cc(O)ccc2c(=O)c1Cc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C28H20O4/c29-22-12-10-21(11-13-22)28-25(27(31)24-15-14-23(30)17-26(24)32-28)16-18-6-8-20(9-7-18)19-4-2-1-3-5-19/h1-15,17,29-30H,16H2
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7.80E+3n/an/an/an/an/an/an/an/a



University of Modena and R.E.

Curated by ChEMBL


Assay Description
Inhibition of human cloned LMW-PTP isoform 2 expressed in Escherichia coli TB1 by mixed type inhibition assay


Bioorg Med Chem 17: 2658-72 (2009)


Article DOI: 10.1016/j.bmc.2009.02.060
BindingDB Entry DOI: 10.7270/Q2K0745F
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM50312261
PNG
((4-(4-bromo-3,5-bis(trifluoromethyl)phenylcarbamoy...)
Show SMILES OP(O)(=O)C(F)(F)c1ccc(cc1)C(=O)Nc1cc(c(Br)c(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C16H9BrF8NO4P/c17-12-10(14(18,19)20)5-9(6-11(12)15(21,22)23)26-13(27)7-1-3-8(4-2-7)16(24,25)31(28,29)30/h1-6H,(H,26,27)(H2,28,29,30)
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1.48E+4n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of human HCPTPA


Bioorg Med Chem Lett 19: 6851-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.090
BindingDB Entry DOI: 10.7270/Q21G0MDK
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM41069
PNG
(3-Chloro-benzo[b]thiophene-2-carboxylic acid (3-ox...)
Show SMILES Clc1c(sc2ccccc12)C(=O)Nc1cccc(c1)-c1nc2ncccc2o1
Show InChI InChI=1S/C21H12ClN3O2S/c22-17-14-7-1-2-9-16(14)28-18(17)20(26)24-13-6-3-5-12(11-13)21-25-19-15(27-21)8-4-10-23-19/h1-11H,(H,24,26)
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n/an/a>8.00E+4n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2JD4VDZ
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM41668
PNG
(1-(3-imidazol-1-ylpropyl)-2-imino-10-methyl-5-oxo-...)
Show SMILES Cc1cccn2c1nc1n(CCCn3ccnc3)c(=N)c(cc1c2=O)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C27H27N7O2/c1-19-7-5-14-34-24(19)31-25-22(27(34)36)17-21(26(35)30-11-10-20-8-3-2-4-9-20)23(28)33(25)15-6-13-32-16-12-29-18-32/h2-5,7-9,12,14,16-18,28H,6,10-11,13,15H2,1H3,(H,30,35)
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n/an/a>8.00E+4n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

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PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2JD4VDZ
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM33051
PNG
((4-chlorodithiazol-5-ylidene)-(3,4,5-trimethoxyphe...)
Show SMILES COc1cc(cc(OC)c1OC)\N=c1\ssnc1Cl
Show InChI InChI=1S/C11H11ClN2O3S2/c1-15-7-4-6(5-8(16-2)9(7)17-3)13-11-10(12)14-19-18-11/h4-5H,1-3H3/b13-11+
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Burnham Center for Chemical Genomics

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PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2JD4VDZ
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM52274
PNG
(2-amino-4-[4-(2-chloro-6-fluoro-benzyl)oxyphenyl]-...)
Show SMILES Fc1cccc(Cl)c1COc1ccc(cc1)C1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1ccco1
Show InChI InChI=1S/C27H20ClFN2O4/c28-20-3-1-4-21(29)19(20)14-34-17-8-6-15(7-9-17)25-18(13-30)27(31)35-24-12-16(11-22(32)26(24)25)23-5-2-10-33-23/h1-10,16,18,25,31H,11-12,14H2
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n/an/a>8.00E+4n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

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PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2JD4VDZ
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM57100
PNG
(1-Ethyl-6-fluoro-7-[4-(furan-2-carbonyl)-piperazin...)
Show SMILES CCn1cc(C(=O)NCc2ccc3OCOc3c2)c(=O)c2cc(F)c(cc12)N1CCN(CC1)C(=O)c1ccco1
Show InChI InChI=1S/C29H27FN4O6/c1-2-32-16-20(28(36)31-15-18-5-6-24-26(12-18)40-17-39-24)27(35)19-13-21(30)23(14-22(19)32)33-7-9-34(10-8-33)29(37)25-4-3-11-38-25/h3-6,11-14,16H,2,7-10,15,17H2,1H3,(H,31,36)
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Burnham Center for Chemical Genomics

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PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2JD4VDZ
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM29622
PNG
(MLS000078195 | SMR000041517 | cid_660761)
Show SMILES Cc1cc(C)cc(c1)-n1c2ncn(Cc3ccco3)c(=O)c2c2nc3ccccc3nc12
Show InChI InChI=1S/C25H19N5O2/c1-15-10-16(2)12-17(11-15)30-23-21(22-24(30)28-20-8-4-3-7-19(20)27-22)25(31)29(14-26-23)13-18-6-5-9-32-18/h3-12,14H,13H2,1-2H3
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Burnham Center for Chemical Genomics

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BindingDB Entry DOI: 10.7270/Q2JD4VDZ
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM55022
PNG
(1-cyclopropyl-6-fluoranyl-8-methoxy-7-[3-methyl-4-...)
Show SMILES COc1c(N2CCN(C(C)C2)C(=S)NCc2ccccc2)c(F)cc2c1n(cc(C(O)=O)c2=O)C1CC1
Show InChI InChI=1S/C27H29FN4O4S/c1-16-14-30(10-11-31(16)27(37)29-13-17-6-4-3-5-7-17)23-21(28)12-19-22(25(23)36-2)32(18-8-9-18)15-20(24(19)33)26(34)35/h3-7,12,15-16,18H,8-11,13-14H2,1-2H3,(H,29,37)(H,34,35)
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Burnham Center for Chemical Genomics

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PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2JD4VDZ
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM94945
PNG
(4-N,6-N-dimethyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-...)
Show SMILES CNc1nc(NC)c2c[nH]nc2n1
Show InChI InChI=1S/C7H10N6/c1-8-5-4-3-10-13-6(4)12-7(9-2)11-5/h3H,1-2H3,(H3,8,9,10,11,12,13)
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n/an/a 3.30E+4n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

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PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2JD4VDZ
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM95057
PNG
((2H-acenaphthylen-1-ylideneamino)thiourea | (acena...)
Show SMILES NC(=S)NN=C1Cc2cccc3cccc1c23
Show InChI InChI=1S/C13H11N3S/c14-13(17)16-15-11-7-9-5-1-3-8-4-2-6-10(11)12(8)9/h1-6H,7H2,(H3,14,16,17)
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n/an/a 4.94E+3n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

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PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2JD4VDZ
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM48754
PNG
(2-(2-chlorophenyl)-N'-(2-keto-5-nitro-indol-3-yl)c...)
Show SMILES [O-][N+](=O)c1ccc2[N-]C(=O)\C(=[NH+]/NC(=O)c3cc(nc4ccccc34)-c3ccccc3Cl)c2c1
Show InChI InChI=1S/C24H14ClN5O4/c25-18-7-3-1-6-15(18)21-12-16(14-5-2-4-8-19(14)26-21)23(31)29-28-22-17-11-13(30(33)34)9-10-20(17)27-24(22)32/h1-12H,(H2,26,27,28,29,31,32)
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Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2JD4VDZ
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM29680
PNG
(2-[(6,7-dihydroxy-2-keto-chromen-4-yl)methylthio]-...)
Show SMILES COc1cccc(c1)-n1c(SCc2cc(=O)oc3cc(O)c(O)cc23)nc2ccccc2c1=O
Show InChI InChI=1S/C25H18N2O6S/c1-32-16-6-4-5-15(10-16)27-24(31)17-7-2-3-8-19(17)26-25(27)34-13-14-9-23(30)33-22-12-21(29)20(28)11-18(14)22/h2-12,28-29H,13H2,1H3
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Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2JD4VDZ
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM83192
PNG
(MLS002694815 | N'-(4-chlorobenzoyl)naphthalene-2-c...)
Show SMILES Clc1ccc(cc1)C(=O)NNC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C18H13ClN2O2/c19-16-9-7-13(8-10-16)17(22)20-21-18(23)15-6-5-12-3-1-2-4-14(12)11-15/h1-11H,(H,20,22)(H,21,23)
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n/an/a 5.41E+4n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2JD4VDZ
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM94930
PNG
(MLS002693565 | N-(4-keto-1H-1,8-naphthyridin-2-yl)...)
Show SMILES CC(=O)Nc1cc(O)c2cccnc2n1
Show InChI InChI=1S/C10H9N3O2/c1-6(14)12-9-5-8(15)7-3-2-4-11-10(7)13-9/h2-5H,1H3,(H2,11,12,13,14,15)
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Burnham Center for Chemical Genomics

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PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2JD4VDZ
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM94961
PNG
(6-methoxy-5-[(6-methoxy-5-quinolinyl)methyl]quinol...)
Show SMILES COc1ccc2ncccc2c1Cc1c(OC)ccc2ncccc12
Show InChI InChI=1S/C21H18N2O2/c1-24-20-9-7-18-14(5-3-11-22-18)16(20)13-17-15-6-4-12-23-19(15)8-10-21(17)25-2/h3-12H,13H2,1-2H3
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Burnham Center for Chemical Genomics

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PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2JD4VDZ
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM94955
PNG
(Indolizine, 1-methyl-3-[4-[2-(dimethylamino)ethoxy...)
Show SMILES CN(C)CCOc1ccc(cc1)-c1c(c(C)c2ccccn12)-c1ccccc1
Show InChI InChI=1S/C25H26N2O/c1-19-23-11-7-8-16-27(23)25(24(19)20-9-5-4-6-10-20)21-12-14-22(15-13-21)28-18-17-26(2)3/h4-16H,17-18H2,1-3H3
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Burnham Center for Chemical Genomics

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PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2JD4VDZ
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM94892
PNG
(5-(3-azido-4-chloranyl-phenyl)-6-ethyl-pyrimidine-...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc(Cl)c(c1)N=[N+]=[N-]
Show InChI InChI=1S/C12H12ClN7/c1-2-8-10(11(14)18-12(15)17-8)6-3-4-7(13)9(5-6)19-20-16/h3-5H,2H2,1H3,(H4,14,15,17,18)
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n/an/a 2.42E+4n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

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PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2JD4VDZ
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM50154449
PNG
(5-[4-(2-Amino-ethylamino)-3-nitro-phenyl]-6-ethyl-...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc(NCCN)c(c1)[N+]([O-])=O
Show InChI InChI=1S/C14H19N7O2/c1-2-9-12(13(16)20-14(17)19-9)8-3-4-10(18-6-5-15)11(7-8)21(22)23/h3-4,7,18H,2,5-6,15H2,1H3,(H4,16,17,19,20)
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Burnham Center for Chemical Genomics

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PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2JD4VDZ
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM89217
PNG
(2-[3-[[4-[(3-nitro-9-acridinyl)amino]phenyl]sulfam...)
Show SMILES NC(=[NH2+])[N-]CCCS(=O)(=O)Nc1ccc(Nc2c3ccccc3nc3cc(ccc23)[N+]([O-])=O)cc1
Show InChI InChI=1S/C23H22N7O4S/c24-23(25)26-12-3-13-35(33,34)29-16-8-6-15(7-9-16)27-22-18-4-1-2-5-20(18)28-21-14-17(30(31)32)10-11-19(21)22/h1-2,4-11,14,29H,3,12-13H2,(H4-,24,25,26,27,28)/q-1/p+1
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Burnham Center for Chemical Genomics

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PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2JD4VDZ
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM94892
PNG
(5-(3-azido-4-chloranyl-phenyl)-6-ethyl-pyrimidine-...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc(Cl)c(c1)N=[N+]=[N-]
Show InChI InChI=1S/C12H12ClN7/c1-2-8-10(11(14)18-12(15)17-8)6-3-4-7(13)9(5-6)19-20-16/h3-5H,2H2,1H3,(H4,14,15,17,18)
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n/an/a 2.41E+4n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

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PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2JD4VDZ
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM94897
PNG
(6-methyl-5-(4-nitrophenyl)pyrimidine-2,4-diamine |...)
Show SMILES Cc1nc(N)nc(N)c1-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C11H11N5O2/c1-6-9(10(12)15-11(13)14-6)7-2-4-8(5-3-7)16(17)18/h2-5H,1H3,(H4,12,13,14,15)
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Burnham Center for Chemical Genomics

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PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2JD4VDZ
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM88811
PNG
((2,3,4,5-tetrachlorocyclopenta-2,4-dien-1-ylidene)...)
Show SMILES NN=C1C(Cl)=C(Cl)C(Cl)=C1Cl
Show InChI InChI=1S/C5H2Cl4N2/c6-1-2(7)4(9)5(11-10)3(1)8/h10H2
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Burnham Center for Chemical Genomics

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PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2JD4VDZ
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM94981
PNG
(1-methyl-6H-pyrido[4,3-b]carbazole | MLS002920539 ...)
Show SMILES Cc1nccc2cc3[nH]c4ccccc4c3cc12
Show InChI InChI=1S/C16H12N2/c1-10-13-9-14-12-4-2-3-5-15(12)18-16(14)8-11(13)6-7-17-10/h2-9,18H,1H3
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Burnham Center for Chemical Genomics

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PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2JD4VDZ
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM94913
PNG
(1-[4-(dimethylamino)phenyl]-3-(4-nitrophenyl)-2-pr...)
Show SMILES CN(C)c1ccc(cc1)C(=O)\C=C\c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C17H16N2O3/c1-18(2)15-10-6-14(7-11-15)17(20)12-5-13-3-8-16(9-4-13)19(21)22/h3-12H,1-2H3/b12-5+
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Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2JD4VDZ
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM94947
PNG
(8-bromanyl-4-oxidanylidene-N-[(1R)-1-phenylethyl]-...)
Show SMILES C[C@@H](NC(=O)c1ncn2c1c(=O)[nH]c1ccc(Br)cc21)c1ccccc1
Show InChI InChI=1S/C19H15BrN4O2/c1-11(12-5-3-2-4-6-12)22-18(25)16-17-19(26)23-14-8-7-13(20)9-15(14)24(17)10-21-16/h2-11H,1H3,(H,22,25)(H,23,26)/t11-/m1/s1
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Burnham Center for Chemical Genomics

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PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2JD4VDZ
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM94958
PNG
((2S)-2-[(8-bromo-4-keto-5H-imidazo[1,5-a]quinoxali...)
Show SMILES CC(C)(C)OC(=O)[C@H](Cc1ccccc1)NC(=O)c1ncn2c1c(=O)[nH]c1ccc(Br)cc21
Show InChI InChI=1S/C24H23BrN4O4/c1-24(2,3)33-23(32)17(11-14-7-5-4-6-8-14)28-21(30)19-20-22(31)27-16-10-9-15(25)12-18(16)29(20)13-26-19/h4-10,12-13,17H,11H2,1-3H3,(H,27,31)(H,28,30)/t17-/m0/s1
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Burnham Center for Chemical Genomics

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PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2JD4VDZ
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM89029
PNG
(5-[1-(4-keto-2-thioxo-thiazolidin-5-yl)ethyl]-2-th...)
Show SMILES CC(c1sc(S)nc1O)c1sc(S)nc1O
Show InChI InChI=1S/C8H8N2O2S4/c1-2(3-5(11)9-7(13)15-3)4-6(12)10-8(14)16-4/h2,11-12H,1H3,(H,9,13)(H,10,14)
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Burnham Center for Chemical Genomics

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PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2JD4VDZ
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM94882
PNG
((4-isopropylbenzyl)-[2-(2-methoxyethylamino)thieno...)
Show SMILES COCCNc1nc(NCc2ccc(cc2)C(C)C)c2sccc2n1
Show InChI InChI=1S/C19H24N4OS/c1-13(2)15-6-4-14(5-7-15)12-21-18-17-16(8-11-25-17)22-19(23-18)20-9-10-24-3/h4-8,11,13H,9-10,12H2,1-3H3,(H2,20,21,22,23)
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Burnham Center for Chemical Genomics

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PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2JD4VDZ
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM94926
PNG
(2-N-(2-methoxyethyl)-4-N-[(5-methylpyrazin-2-yl)me...)
Show SMILES COCCNc1nc(NCc2cnc(C)cn2)c2sccc2n1
Show InChI InChI=1S/C15H18N6OS/c1-10-7-18-11(8-17-10)9-19-14-13-12(3-6-23-13)20-15(21-14)16-4-5-22-2/h3,6-8H,4-5,9H2,1-2H3,(H2,16,19,20,21)
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Burnham Center for Chemical Genomics

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PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2JD4VDZ
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM89032
PNG
(MLS001029357 | N-(3-chloranyl-4-methoxy-phenyl)-3-...)
Show SMILES COc1ccc(NC(=O)CCn2c(=S)[nH]c3ccccc3c2=O)cc1Cl
Show InChI InChI=1S/C18H16ClN3O3S/c1-25-15-7-6-11(10-13(15)19)20-16(23)8-9-22-17(24)12-4-2-3-5-14(12)21-18(22)26/h2-7,10H,8-9H2,1H3,(H,20,23)(H,21,26)
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Burnham Center for Chemical Genomics

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PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2JD4VDZ
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM88812
PNG
(6-keto-N-(2-methyl-5-piperidinosulfonyl-phenyl)-1H...)
Show SMILES Cc1ccc(cc1NC(=O)c1ccc(=O)[nH]c1)S(=O)(=O)N1CCCCC1
Show InChI InChI=1S/C18H21N3O4S/c1-13-5-7-15(26(24,25)21-9-3-2-4-10-21)11-16(13)20-18(23)14-6-8-17(22)19-12-14/h5-8,11-12H,2-4,9-10H2,1H3,(H,19,22)(H,20,23)
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Burnham Center for Chemical Genomics

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PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2JD4VDZ
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM89223
PNG
(2-(2-Thiophen-2-yl-acetylamino)-terephthalic acid ...)
Show SMILES COC(=O)c1ccc(C(=O)OC)c(NC(=O)Cc2cccs2)c1
Show InChI InChI=1S/C16H15NO5S/c1-21-15(19)10-5-6-12(16(20)22-2)13(8-10)17-14(18)9-11-4-3-7-23-11/h3-8H,9H2,1-2H3,(H,17,18)
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Burnham Center for Chemical Genomics

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PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2JD4VDZ
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM94890
PNG
(1,3-Dimethyl-5,6-dinitro-2-[3-(1,3,3-trimethyl-1,3...)
Show SMILES CN1\C(=C\C=C\c2n(C)c3cc(c(cc3[n+]2C)[N+]([O-])=O)[N+]([O-])=O)C(C)(C)c2ccccc12
Show InChI InChI=1S/C23H24N5O4/c1-23(2)15-9-6-7-10-16(15)24(3)21(23)11-8-12-22-25(4)17-13-19(27(29)30)20(28(31)32)14-18(17)26(22)5/h6-14H,1-5H3/q+1
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Burnham Center for Chemical Genomics

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PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2JD4VDZ
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM94914
PNG
(MLS003123031 | N-[4-[[[2-(2-thenylamino)thieno[3,2...)
Show SMILES CC(=O)Nc1ccc(CNc2nc(NCc3cccs3)nc3ccsc23)cc1
Show InChI InChI=1S/C20H19N5OS2/c1-13(26)23-15-6-4-14(5-7-15)11-21-19-18-17(8-10-28-18)24-20(25-19)22-12-16-3-2-9-27-16/h2-10H,11-12H2,1H3,(H,23,26)(H2,21,22,24,25)
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n/an/a 1.55E+4n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

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PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2JD4VDZ
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM94970
PNG
(1-(3,4-dihydroxyphenyl)-2-(methylamino)ethanone | ...)
Show SMILES CNCC(=O)c1ccc(O)c(O)c1
Show InChI InChI=1S/C9H11NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,10-12H,5H2,1H3
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n/an/a>8.00E+4n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2JD4VDZ
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM95060
PNG
(MLS003122837 | N-[4-[[[2-(cyclopropylmethylamino)-...)
Show SMILES CC(=O)Nc1ccc(CNc2nc(NCC3CC3)nc3ccsc23)cc1
Show InChI InChI=1S/C19H21N5OS/c1-12(25)22-15-6-4-14(5-7-15)10-20-18-17-16(8-9-26-17)23-19(24-18)21-11-13-2-3-13/h4-9,13H,2-3,10-11H2,1H3,(H,22,25)(H2,20,21,23,24)
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n/an/a 1.70E+4n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2JD4VDZ
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM94948
PNG
(MLS003123024 | N-[4-[[[2-(o-anisylamino)thieno[3,2...)
Show SMILES COc1ccccc1CNc1nc(NCc2ccc(NC(C)=O)cc2)c2sccc2n1
Show InChI InChI=1S/C23H23N5O2S/c1-15(29)26-18-9-7-16(8-10-18)13-24-22-21-19(11-12-31-21)27-23(28-22)25-14-17-5-3-4-6-20(17)30-2/h3-12H,13-14H2,1-2H3,(H,26,29)(H2,24,25,27,28)
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n/an/a 5.86E+3n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2JD4VDZ
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM31737
PNG
(2-[5-[(Z)-(1-keto-5,7-dimethyl-thiazolo[3,2-a]benz...)
Show SMILES Cc1cc(C)c2nc3s\c(=C/c4ccc(o4)-c4ccccc4C(O)=O)c(=O)n3c2c1
Show InChI InChI=1S/C23H16N2O4S/c1-12-9-13(2)20-17(10-12)25-21(26)19(30-23(25)24-20)11-14-7-8-18(29-14)15-5-3-4-6-16(15)22(27)28/h3-11H,1-2H3,(H,27,28)/b19-11-
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n/an/a 2.65E+4n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2JD4VDZ
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM46213
PNG
(2-[4-[[6-carbethoxy-3-keto-7-methyl-5-[4-(methylth...)
Show SMILES CCOC(=O)C1=C(C)N=c2sc(=Cc3ccc(OCC(O)=O)cc3)c(=O)n2C1c1ccc(SC)cc1
Show InChI InChI=1S/C26H24N2O6S2/c1-4-33-25(32)22-15(2)27-26-28(23(22)17-7-11-19(35-3)12-8-17)24(31)20(36-26)13-16-5-9-18(10-6-16)34-14-21(29)30/h5-13,23H,4,14H2,1-3H3,(H,29,30)
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n/an/a 5.28E+4n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2JD4VDZ
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM46214
PNG
(2-[4-[[5-(4-chlorophenyl)-6-ethoxycarbonyl-7-methy...)
Show SMILES CCOC(=O)C1=C(C)N=c2sc(=Cc3ccc(OCC(O)=O)cc3)c(=O)n2C1c1ccc(Cl)cc1
Show InChI InChI=1S/C25H21ClN2O6S/c1-3-33-24(32)21-14(2)27-25-28(22(21)16-6-8-17(26)9-7-16)23(31)19(35-25)12-15-4-10-18(11-5-15)34-13-20(29)30/h4-12,22H,3,13H2,1-2H3,(H,29,30)
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n/an/a>8.00E+4n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2JD4VDZ
More data for this
Ligand-Target Pair
Low molecular weight phosphotyrosine protein phosphatase (LMWPTP)


(Homo sapiens (Human))
BDBM46215
PNG
(2-[4-[[5-(4-chlorophenyl)-6-isopropoxycarbonyl-3-k...)
Show SMILES CC(C)OC(=O)C1=C(C)N=c2sc(=Cc3ccc(OCC(O)=O)cc3)c(=O)n2C1c1ccc(Cl)cc1
Show InChI InChI=1S/C26H23ClN2O6S/c1-14(2)35-25(33)22-15(3)28-26-29(23(22)17-6-8-18(27)9-7-17)24(32)20(36-26)12-16-4-10-19(11-5-16)34-13-21(30)31/h4-12,14,23H,13H2,1-3H3,(H,30,31)
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n/an/a>8.00E+4n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2013)


BindingDB Entry DOI: 10.7270/Q2JD4VDZ
More data for this
Ligand-Target Pair
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