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Found 1265 hits Enz. Inhib. hit(s) with Target = 'Lysine-specific demethylase 5A (KDM5A)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281103
PNG
(US10022354, Example 43)
Show SMILES CCc1cccn([C@@H]2CCN(C2)C(=O)c2cc(n[nH]2)C(C)C)c1=O
Show InChI InChI=1S/C18H24N4O2/c1-4-13-6-5-8-22(17(13)23)14-7-9-21(11-14)18(24)16-10-15(12(2)3)19-20-16/h5-6,8,10,12,14H,4,7,9,11H2,1-3H3,(H,19,20)/t14-/m1/s1
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US Patent
n/an/a 0.0390n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281104
PNG
(US10022354, Example 44)
Show SMILES Cc1cc(n[nH]1)C(=O)N1CCC(C1)c1cc(cc(C)n1)-c1ccn(C)c1
Show InChI InChI=1S/C20H23N5O/c1-13-8-17(15-4-6-24(3)11-15)10-18(21-13)16-5-7-25(12-16)20(26)19-9-14(2)22-23-19/h4,6,8-11,16H,5,7,12H2,1-3H3,(H,22,23)
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n/an/a 2.70n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281105
PNG
(US10022354, Example 45)
Show SMILES CCc1cc([nH]n1)C(=O)N1CCC(C1)c1cc(cc(C)n1)-c1cnn(C)c1
Show InChI InChI=1S/C20H24N6O/c1-4-17-9-19(24-23-17)20(27)26-6-5-14(12-26)18-8-15(7-13(2)22-18)16-10-21-25(3)11-16/h7-11,14H,4-6,12H2,1-3H3,(H,23,24)
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n/an/a 0.910n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281106
PNG
(US10022354, Example 46)
Show SMILES CCCc1cc([nH]n1)C(=O)N1CCC(C1)c1cc(cc(C)n1)-c1cnn(C)c1
Show InChI InChI=1S/C21H26N6O/c1-4-5-18-10-20(25-24-18)21(28)27-7-6-15(13-27)19-9-16(8-14(2)23-19)17-11-22-26(3)12-17/h8-12,15H,4-7,13H2,1-3H3,(H,24,25)
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n/an/a 0.540n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281107
PNG
(US10022354, Example 47)
Show SMILES Cc1cc(cc(n1)C1CCN(C1)C(=O)c1cc(n[nH]1)C1CC1)-c1cnn(C)c1
Show InChI InChI=1S/C21H24N6O/c1-13-7-16(17-10-22-26(2)11-17)8-18(23-13)15-5-6-27(12-15)21(28)20-9-19(24-25-20)14-3-4-14/h7-11,14-15H,3-6,12H2,1-2H3,(H,24,25)
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n/an/a 0.400n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281108
PNG
(US10022354, Example 48)
Show SMILES Cc1cc(cc(n1)C1CCN(C1)C(=O)c1cc(n[nH]1)C(C)(C)C)-c1cnn(C)c1
Show InChI InChI=1S/C22H28N6O/c1-14-8-16(17-11-23-27(5)12-17)9-18(24-14)15-6-7-28(13-15)21(29)19-10-20(26-25-19)22(2,3)4/h8-12,15H,6-7,13H2,1-5H3,(H,25,26)
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n/an/a 0.900n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281109
PNG
(US10022354, Example 49)
Show SMILES Cc1cc(cc(n1)C1CCN(C1)C(=O)c1cc(n[nH]1)-c1ccccc1)-c1cnn(C)c1
Show InChI InChI=1S/C24H24N6O/c1-16-10-19(20-13-25-29(2)14-20)11-21(26-16)18-8-9-30(15-18)24(31)23-12-22(27-28-23)17-6-4-3-5-7-17/h3-7,10-14,18H,8-9,15H2,1-2H3,(H,27,28)
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n/an/a 3.60n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281110
PNG
(US10022354, Example 50)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CCC(C1)c1ccccn1
Show InChI InChI=1S/C16H20N4O/c1-11(2)14-9-15(19-18-14)16(21)20-8-6-12(10-20)13-5-3-4-7-17-13/h3-5,7,9,11-12H,6,8,10H2,1-2H3,(H,18,19)
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n/an/a 6.10n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281111
PNG
(US10022354, Example 51)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CCC(C1)c1cccc(C)n1
Show InChI InChI=1S/C17H22N4O/c1-11(2)15-9-16(20-19-15)17(22)21-8-7-13(10-21)14-6-4-5-12(3)18-14/h4-6,9,11,13H,7-8,10H2,1-3H3,(H,19,20)
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n/an/a 2.40n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281112
PNG
(US10022354, Example 52)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CCC(C1)Oc1ccccn1
Show InChI InChI=1S/C16H20N4O2/c1-11(2)13-9-14(19-18-13)16(21)20-8-6-12(10-20)22-15-5-3-4-7-17-15/h3-5,7,9,11-12H,6,8,10H2,1-2H3,(H,18,19)
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n/an/a 14n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281113
PNG
(US10022354, Example 53)
Show SMILES CNC(=O)c1cc(C)nc(c1)C1CCN(C1)C(=O)c1cc(n[nH]1)C(C)C
Show InChI InChI=1S/C19H25N5O2/c1-11(2)15-9-17(23-22-15)19(26)24-6-5-13(10-24)16-8-14(18(25)20-4)7-12(3)21-16/h7-9,11,13H,5-6,10H2,1-4H3,(H,20,25)(H,22,23)
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n/an/a 4.20n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281114
PNG
(US10022354, Example 54)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CCC(C1)c1cc(NC(C)=O)cc(C)n1
Show InChI InChI=1S/C19H25N5O2/c1-11(2)16-9-18(23-22-16)19(26)24-6-5-14(10-24)17-8-15(21-13(4)25)7-12(3)20-17/h7-9,11,14H,5-6,10H2,1-4H3,(H,22,23)(H,20,21,25)
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n/an/a 1.70n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281115
PNG
(US10022354, Example 55)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CCC(C1)c1cc(NC(=O)c2ccccc2)cc(C)n1
Show InChI InChI=1S/C24H27N5O2/c1-15(2)20-13-22(28-27-20)24(31)29-10-9-18(14-29)21-12-19(11-16(3)25-21)26-23(30)17-7-5-4-6-8-17/h4-8,11-13,15,18H,9-10,14H2,1-3H3,(H,27,28)(H,25,26,30)
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n/an/a 1.20n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281116
PNG
(US10022354, Example 56)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CCC(C1)c1cc(NS(C)(=O)=O)cc(C)n1
Show InChI InChI=1S/C18H25N5O3S/c1-11(2)15-9-17(21-20-15)18(24)23-6-5-13(10-23)16-8-14(7-12(3)19-16)22-27(4,25)26/h7-9,11,13H,5-6,10H2,1-4H3,(H,19,22)(H,20,21)
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n/an/a 16n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281117
PNG
(US10022354, Example 57)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CCC(C1)c1cc(NS(=O)(=O)c2ccccc2)cc(C)n1
Show InChI InChI=1S/C23H27N5O3S/c1-15(2)20-13-22(26-25-20)23(29)28-10-9-17(14-28)21-12-18(11-16(3)24-21)27-32(30,31)19-7-5-4-6-8-19/h4-8,11-13,15,17H,9-10,14H2,1-3H3,(H,24,27)(H,25,26)
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n/an/a 17n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281118
PNG
(US10022354, Example 58)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CCC(C1)C(=O)NCc1cnn(C)c1
Show InChI InChI=1S/C17H24N6O2/c1-11(2)14-6-15(21-20-14)17(25)23-5-4-13(10-23)16(24)18-7-12-8-19-22(3)9-12/h6,8-9,11,13H,4-5,7,10H2,1-3H3,(H,18,24)(H,20,21)
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n/an/a 15n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281119
PNG
(US10022354, Example 59)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CCC(C1)n1cc(Br)cn1
Show InChI InChI=1S/C14H18BrN5O/c1-9(2)12-5-13(18-17-12)14(21)19-4-3-11(8-19)20-7-10(15)6-16-20/h5-7,9,11H,3-4,8H2,1-2H3,(H,17,18)
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n/an/a 0.740n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281120
PNG
(US10022354, Example 60)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CCC(C1)N1CCCC1=O
Show InChI InChI=1S/C15H22N4O2/c1-10(2)12-8-13(17-16-12)15(21)18-7-5-11(9-18)19-6-3-4-14(19)20/h8,10-11H,3-7,9H2,1-2H3,(H,16,17)
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n/an/a 7.10n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281121
PNG
(US10022354, Example 61)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CCC(C1)c1cc(cc(C)n1)-c1cccc(C)c1
Show InChI InChI=1S/C24H28N4O/c1-15(2)21-13-23(27-26-21)24(29)28-9-8-19(14-28)22-12-20(11-17(4)25-22)18-7-5-6-16(3)10-18/h5-7,10-13,15,19H,8-9,14H2,1-4H3,(H,26,27)
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n/an/a 0.120n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281122
PNG
(US10022354, Example 62)
Show SMILES COc1cccc(c1)-c1cc(C)nc(c1)C1CCN(C1)C(=O)c1cc(n[nH]1)C(C)C
Show InChI InChI=1S/C24H28N4O2/c1-15(2)21-13-23(27-26-21)24(29)28-9-8-18(14-28)22-12-19(10-16(3)25-22)17-6-5-7-20(11-17)30-4/h5-7,10-13,15,18H,8-9,14H2,1-4H3,(H,26,27)
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n/an/a 0.220n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281123
PNG
(US10022354, Example 63)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CCC(C1)c1cc(cc(C)n1)-c1ccn[nH]1
Show InChI InChI=1S/C20H24N6O/c1-12(2)17-10-19(25-24-17)20(27)26-7-5-14(11-26)18-9-15(8-13(3)22-18)16-4-6-21-23-16/h4,6,8-10,12,14H,5,7,11H2,1-3H3,(H,21,23)(H,24,25)
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n/an/a 0.350n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281124
PNG
(US10022354, Example 64)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CCC(C1)c1cc(cc(C)n1)-c1ccccc1
Show InChI InChI=1S/C23H26N4O/c1-15(2)20-13-22(26-25-20)23(28)27-10-9-18(14-27)21-12-19(11-16(3)24-21)17-7-5-4-6-8-17/h4-8,11-13,15,18H,9-10,14H2,1-3H3,(H,25,26)
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n/an/a 0.230n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281125
PNG
(US10022354, Example 65)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CCC(C1)c1cc(cc(C)n1)-c1ccncc1
Show InChI InChI=1S/C22H25N5O/c1-14(2)19-12-21(26-25-19)22(28)27-9-6-17(13-27)20-11-18(10-15(3)24-20)16-4-7-23-8-5-16/h4-5,7-8,10-12,14,17H,6,9,13H2,1-3H3,(H,25,26)
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n/an/a 0.370n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281126
PNG
(US10022354, Example 66)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CCC(C1)c1cc(cc(C)n1)-c1ccccc1C
Show InChI InChI=1S/C24H28N4O/c1-15(2)21-13-23(27-26-21)24(29)28-10-9-18(14-28)22-12-19(11-17(4)25-22)20-8-6-5-7-16(20)3/h5-8,11-13,15,18H,9-10,14H2,1-4H3,(H,26,27)
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n/an/a 0.25n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281127
PNG
(US10022354, Example 67)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CCC(C1)c1cc(cc(C)n1)-c1cccc(c1)C#N
Show InChI InChI=1S/C24H25N5O/c1-15(2)21-12-23(28-27-21)24(30)29-8-7-19(14-29)22-11-20(9-16(3)26-22)18-6-4-5-17(10-18)13-25/h4-6,9-12,15,19H,7-8,14H2,1-3H3,(H,27,28)
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n/an/a 0.350n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281128
PNG
(US10022354, Example 68)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CCC(C1)c1cc(cc(C)n1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C24H25N5O/c1-15(2)21-12-23(28-27-21)24(30)29-9-8-19(14-29)22-11-20(10-16(3)26-22)18-6-4-17(13-25)5-7-18/h4-7,10-12,15,19H,8-9,14H2,1-3H3,(H,27,28)
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n/an/a 0.290n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281285
PNG
(US10022354, Example 225)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CC[C@@H](C1)NC(=O)C1(C)CC1
Show InChI InChI=1S/C16H24N4O2/c1-10(2)12-8-13(19-18-12)14(21)20-7-4-11(9-20)17-15(22)16(3)5-6-16/h8,10-11H,4-7,9H2,1-3H3,(H,17,22)(H,18,19)/t11-/m0/s1
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n/an/a 0.110n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281286
PNG
(US10022354, Example 226)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CC[C@H](C1)NC(=O)C1(CC1)C#N
Show InChI InChI=1S/C16H21N5O2/c1-10(2)12-7-13(20-19-12)14(22)21-6-3-11(8-21)18-15(23)16(9-17)4-5-16/h7,10-11H,3-6,8H2,1-2H3,(H,18,23)(H,19,20)/t11-/m1/s1
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n/an/a 0.230n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281287
PNG
(US10022354, Example 227)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CC[C@H](C1)NC(=O)CC#N
Show InChI InChI=1S/C14H19N5O2/c1-9(2)11-7-12(18-17-11)14(21)19-6-4-10(8-19)16-13(20)3-5-15/h7,9-10H,3-4,6,8H2,1-2H3,(H,16,20)(H,17,18)/t10-/m1/s1
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n/an/a 0.240n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281288
PNG
(US10022354, Example 228)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CC[C@H](C1)NC(=O)C1CC11CC1
Show InChI InChI=1S/C17H24N4O2/c1-10(2)13-7-14(20-19-13)16(23)21-6-3-11(9-21)18-15(22)12-8-17(12)4-5-17/h7,10-12H,3-6,8-9H2,1-2H3,(H,18,22)(H,19,20)/t11-,12?/m1/s1
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n/an/a 0.0780n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281289
PNG
(US10022354, Example 229)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CC[C@@H](C1)NC(=O)[C@@H]1C[C@@H]1F
Show InChI InChI=1S/C15H21FN4O2/c1-8(2)12-6-13(19-18-12)15(22)20-4-3-9(7-20)17-14(21)10-5-11(10)16/h6,8-11H,3-5,7H2,1-2H3,(H,17,21)(H,18,19)/t9-,10+,11-/m0/s1
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281290
PNG
(US10022354, Example 230)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CC[C@@H](C1)NC(=O)[C@H]1C[C@H]1F
Show InChI InChI=1S/C15H21FN4O2/c1-8(2)12-6-13(19-18-12)15(22)20-4-3-9(7-20)17-14(21)10-5-11(10)16/h6,8-11H,3-5,7H2,1-2H3,(H,17,21)(H,18,19)/t9-,10-,11+/m0/s1
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n/an/a 0.140n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281291
PNG
(US10022354, Example 231)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CC[C@H](C1)NC(=O)[C@H]1C[C@@H]1F
Show InChI InChI=1S/C15H21FN4O2/c1-8(2)12-6-13(19-18-12)15(22)20-4-3-9(7-20)17-14(21)10-5-11(10)16/h6,8-11H,3-5,7H2,1-2H3,(H,17,21)(H,18,19)/t9-,10+,11+/m1/s1
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n/an/a 0.330n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281292
PNG
(US10022354, Example 232)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CC[C@H](C1)NC(=O)[C@@H]1C[C@H]1F
Show InChI InChI=1S/C15H21FN4O2/c1-8(2)12-6-13(19-18-12)15(22)20-4-3-9(7-20)17-14(21)10-5-11(10)16/h6,8-11H,3-5,7H2,1-2H3,(H,17,21)(H,18,19)/t9-,10-,11-/m1/s1
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281293
PNG
(US10022354, Example 233)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CCC(C1)n1nc(C)cc1C
Show InChI InChI=1S/C16H23N5O/c1-10(2)14-8-15(18-17-14)16(22)20-6-5-13(9-20)21-12(4)7-11(3)19-21/h7-8,10,13H,5-6,9H2,1-4H3,(H,17,18)
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n/an/a 12n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281294
PNG
(US10022354, Example 234 | US10022354, Example 237)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CCC(C1)n1cc(Br)c(C)n1
Show InChI InChI=1S/C15H20BrN5O/c1-9(2)13-6-14(18-17-13)15(22)20-5-4-11(7-20)21-8-12(16)10(3)19-21/h6,8-9,11H,4-5,7H2,1-3H3,(H,17,18)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281295
PNG
(US10022354, Example 235)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CCC(C1)n1cc2CCCc2n1
Show InChI InChI=1S/C17H23N5O/c1-11(2)15-8-16(19-18-15)17(23)21-7-6-13(10-21)22-9-12-4-3-5-14(12)20-22/h8-9,11,13H,3-7,10H2,1-2H3,(H,18,19)
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n/an/a 0.340n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281296
PNG
(US10022354, Example 236)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CCC(C1)n1cc(c(C)n1)-c1ccccc1
Show InChI InChI=1S/C21H25N5O/c1-14(2)19-11-20(23-22-19)21(27)25-10-9-17(12-25)26-13-18(15(3)24-26)16-7-5-4-6-8-16/h4-8,11,13-14,17H,9-10,12H2,1-3H3,(H,22,23)
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n/an/a 0.320n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281294
PNG
(US10022354, Example 234 | US10022354, Example 237)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CCC(C1)n1cc(Br)c(C)n1
Show InChI InChI=1S/C15H20BrN5O/c1-9(2)13-6-14(18-17-13)15(22)20-5-4-11(7-20)21-8-12(16)10(3)19-21/h6,8-9,11H,4-5,7H2,1-3H3,(H,17,18)
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n/an/a 0.360n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281298
PNG
(US10022354, Example 238)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CCC(C1)n1cc(Br)c(n1)C(C)C
Show InChI InChI=1S/C17H24BrN5O/c1-10(2)14-7-15(20-19-14)17(24)22-6-5-12(8-22)23-9-13(18)16(21-23)11(3)4/h7,9-12H,5-6,8H2,1-4H3,(H,19,20)
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n/an/a 0.150n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281299
PNG
(US10022354, Example 239)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CCC(C1)n1cc(Br)c(n1)C(F)F
Show InChI InChI=1S/C15H18BrF2N5O/c1-8(2)11-5-12(20-19-11)15(24)22-4-3-9(6-22)23-7-10(16)13(21-23)14(17)18/h5,7-9,14H,3-4,6H2,1-2H3,(H,19,20)
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n/an/a 0.350n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281300
PNG
(US10022354, Example 240)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CCC(C1)n1cc(Br)c(n1)C#N
Show InChI InChI=1S/C15H17BrN6O/c1-9(2)12-5-13(19-18-12)15(23)21-4-3-10(7-21)22-8-11(16)14(6-17)20-22/h5,8-10H,3-4,7H2,1-2H3,(H,18,19)
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n/an/a 2.10n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281301
PNG
(US10022354, Example 242)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CC[C@H](C1)n1cc2ccccc2n1
Show InChI InChI=1S/C18H21N5O/c1-12(2)16-9-17(20-19-16)18(24)22-8-7-14(11-22)23-10-13-5-3-4-6-15(13)21-23/h3-6,9-10,12,14H,7-8,11H2,1-2H3,(H,19,20)/t14-/m1/s1
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n/an/a 0.350n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281302
PNG
(US10022354, Example 243)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CC[C@H](C1)n1ncc2ccccc12
Show InChI InChI=1S/C18H21N5O/c1-12(2)15-9-16(21-20-15)18(24)22-8-7-14(11-22)23-17-6-4-3-5-13(17)10-19-23/h3-6,9-10,12,14H,7-8,11H2,1-2H3,(H,20,21)/t14-/m1/s1
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n/an/a 0.920n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281303
PNG
(US10022354, Example 244)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CC[C@H](C1)n1ncc2ccc(Cl)nc12
Show InChI InChI=1S/C17H19ClN6O/c1-10(2)13-7-14(22-21-13)17(25)23-6-5-12(9-23)24-16-11(8-19-24)3-4-15(18)20-16/h3-4,7-8,10,12H,5-6,9H2,1-2H3,(H,21,22)/t12-/m1/s1
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n/an/a 0.840n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281304
PNG
(US10022354, Example 245)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CCC(C1)n1ncc2c(F)cc(Br)cc12
Show InChI InChI=1S/C18H19BrFN5O/c1-10(2)15-7-16(23-22-15)18(26)24-4-3-12(9-24)25-17-6-11(19)5-14(20)13(17)8-21-25/h5-8,10,12H,3-4,9H2,1-2H3,(H,22,23)
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n/an/a 0.910n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281305
PNG
(US10022354, Example 246)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CC[C@H](C1)n1ncc2c(F)cccc12
Show InChI InChI=1S/C18H20FN5O/c1-11(2)15-8-16(22-21-15)18(25)23-7-6-12(10-23)24-17-5-3-4-14(19)13(17)9-20-24/h3-5,8-9,11-12H,6-7,10H2,1-2H3,(H,21,22)/t12-/m1/s1
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n/an/a 0.300n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281306
PNG
(US10022354, Example 247)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CC[C@H](C1)n1cc2c(F)cccc2n1
Show InChI InChI=1S/C18H20FN5O/c1-11(2)16-8-17(21-20-16)18(25)23-7-6-12(9-23)24-10-13-14(19)4-3-5-15(13)22-24/h3-5,8,10-12H,6-7,9H2,1-2H3,(H,20,21)/t12-/m1/s1
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n/an/a 0.430n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281061
PNG
((S)-(3-Isopropyl-1H-pyrazol-5-yl)(3-(6-methyl-4-(1...)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CC[C@@H](C1)c1cc(cc(C)n1)-c1cnn(C)c1
Show InChI InChI=1S/C21H26N6O/c1-13(2)18-9-20(25-24-18)21(28)27-6-5-15(12-27)19-8-16(7-14(3)23-19)17-10-22-26(4)11-17/h7-11,13,15H,5-6,12H2,1-4H3,(H,24,25)/t15-/m0/s1
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n/an/a 0.170n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
Lysine-specific demethylase 5A


(Homo sapiens (Human))
BDBM281062
PNG
(US10022354, Example 2)
Show SMILES CC(C)c1cc([nH]n1)C(=O)N1CC[C@H](C1)c1cc(cc(C)n1)-c1cnn(C)c1
Show InChI InChI=1S/C21H26N6O/c1-13(2)18-9-20(25-24-18)21(28)27-6-5-15(12-27)19-8-16(7-14(3)23-19)17-10-22-26(4)11-17/h7-11,13,15H,5-6,12H2,1-4H3,(H,24,25)/t15-/m1/s1
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n/an/a 0.840n/an/an/an/a7.025



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS INC.

US Patent


Assay Description
Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...


US Patent US10022354 (2018)

More data for this
Ligand-Target Pair
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