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Found 595 hits Enz. Inhib. hit(s) with Target = 'MAP kinase-interacting serine/threonine-protein kinase 1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM98032
PNG
(US8486953, 2)
Show SMILES CCOc1cc(ccc1Nc1ncnc2sc(C(N)=O)c(C)c12)C(N)=O
Show InChI InChI=1S/C17H17N5O3S/c1-3-25-11-6-9(14(18)23)4-5-10(11)22-16-12-8(2)13(15(19)24)26-17(12)21-7-20-16/h4-7H,3H2,1-2H3,(H2,18,23)(H2,19,24)(H,20,21,22)
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n/an/a 120n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro kinase assay using human Mnk1 and Mnk2.


US Patent US8486953 (2013)


BindingDB Entry DOI: 10.7270/Q2TM78R3
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM98033
PNG
(US8486953, 6)
Show SMILES COCCNC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC3CCOCC3)c2c1C
Show InChI InChI=1S/C22H25FN4O4S/c1-13-18-20(25-12-26-22(18)32-19(13)21(28)24-7-10-29-2)27-16-4-3-14(23)11-17(16)31-15-5-8-30-9-6-15/h3-4,11-12,15H,5-10H2,1-2H3,(H,24,28)(H,25,26,27)
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n/an/a 180n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro kinase assay using human Mnk1 and Mnk2.


US Patent US8486953 (2013)


BindingDB Entry DOI: 10.7270/Q2TM78R3
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM98034
PNG
(US8486953, 9)
Show SMILES CN(C)CCCNC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC3CCOCC3)c2c1C
Show InChI InChI=1S/C24H30FN5O3S/c1-15-20-22(27-14-28-24(20)34-21(15)23(31)26-9-4-10-30(2)3)29-18-6-5-16(25)13-19(18)33-17-7-11-32-12-8-17/h5-6,13-14,17H,4,7-12H2,1-3H3,(H,26,31)(H,27,28,29)
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n/an/a 100n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro kinase assay using human Mnk1 and Mnk2.


US Patent US8486953 (2013)


BindingDB Entry DOI: 10.7270/Q2TM78R3
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM98035
PNG
(US8486953, 10)
Show SMILES Cc1c(sc2ncnc(Nc3ccc(F)cc3OC3CCOCC3)c12)C(=O)NCCN1CCOCC1
Show InChI InChI=1S/C25H30FN5O4S/c1-16-21-23(30-19-3-2-17(26)14-20(19)35-18-4-10-33-11-5-18)28-15-29-25(21)36-22(16)24(32)27-6-7-31-8-12-34-13-9-31/h2-3,14-15,18H,4-13H2,1H3,(H,27,32)(H,28,29,30)
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n/an/a 210n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro kinase assay using human Mnk1 and Mnk2.


US Patent US8486953 (2013)


BindingDB Entry DOI: 10.7270/Q2TM78R3
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM98041
PNG
(US8486953, 71)
Show SMILES Cc1c(sc2ncnc(Nc3ccc(F)cc3OC3CCN(CC(=O)N4CCOCC4)CC3)c12)C(N)=O
Show InChI InChI=1S/C25H29FN6O4S/c1-15-21-24(28-14-29-25(21)37-22(15)23(27)34)30-18-3-2-16(26)12-19(18)36-17-4-6-31(7-5-17)13-20(33)32-8-10-35-11-9-32/h2-3,12,14,17H,4-11,13H2,1H3,(H2,27,34)(H,28,29,30)
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n/an/a 400n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro kinase assay using human Mnk1 and Mnk2.


US Patent US8486953 (2013)


BindingDB Entry DOI: 10.7270/Q2TM78R3
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM98037
PNG
(US8486953, 34)
Show SMILES CN(C)CCCNC(=O)c1sc2ncnc(Nc3ccc(nc3OC3CCOCC3)C(F)(F)F)c2c1C
Show InChI InChI=1S/C24H29F3N6O3S/c1-14-18-20(29-13-30-23(18)37-19(14)21(34)28-9-4-10-33(2)3)31-16-5-6-17(24(25,26)27)32-22(16)36-15-7-11-35-12-8-15/h5-6,13,15H,4,7-12H2,1-3H3,(H,28,34)(H,29,30,31)
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n/an/a 680n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro kinase assay using human Mnk1 and Mnk2.


US Patent US8486953 (2013)


BindingDB Entry DOI: 10.7270/Q2TM78R3
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM98038
PNG
(US8486953, 41)
Show SMILES Fc1ccc(Nc2ncnc3sc4CNCCc4c23)c(OC2CCOCC2)c1
Show InChI InChI=1S/C20H21FN4O2S/c21-12-1-2-15(16(9-12)27-13-4-7-26-8-5-13)25-19-18-14-3-6-22-10-17(14)28-20(18)24-11-23-19/h1-2,9,11,13,22H,3-8,10H2,(H,23,24,25)
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n/an/a 210n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro kinase assay using human Mnk1 and Mnk2.


US Patent US8486953 (2013)


BindingDB Entry DOI: 10.7270/Q2TM78R3
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM98039
PNG
(US8486953, 48)
Show SMILES Cc1c(sc2ncnc(Nc3ccc(F)cc3OC3CCN(Cc4ncon4)CC3)c12)C(N)=O
Show InChI InChI=1S/C22H22FN7O3S/c1-12-18-21(25-10-26-22(18)34-19(12)20(24)31)28-15-3-2-13(23)8-16(15)33-14-4-6-30(7-5-14)9-17-27-11-32-29-17/h2-3,8,10-11,14H,4-7,9H2,1H3,(H2,24,31)(H,25,26,28)
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n/an/a 460n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro kinase assay using human Mnk1 and Mnk2.


US Patent US8486953 (2013)


BindingDB Entry DOI: 10.7270/Q2TM78R3
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM98040
PNG
(US8486953, 53)
Show SMILES CC(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)NCCCN(C)C)c(C)c12
Show InChI InChI=1S/C22H28FN5O2S/c1-13(2)30-17-11-15(23)7-8-16(17)27-20-18-14(3)19(31-22(18)26-12-25-20)21(29)24-9-6-10-28(4)5/h7-8,11-13H,6,9-10H2,1-5H3,(H,24,29)(H,25,26,27)
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n/an/a 35n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro kinase assay using human Mnk1 and Mnk2.


US Patent US8486953 (2013)


BindingDB Entry DOI: 10.7270/Q2TM78R3
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM98036
PNG
(US8486953, 19)
Show SMILES COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C)c2c1C
Show InChI InChI=1S/C18H18FN3O3S/c1-9(2)25-13-7-11(19)5-6-12(13)22-16-14-10(3)15(18(23)24-4)26-17(14)21-8-20-16/h5-9H,1-4H3,(H,20,21,22)
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n/an/a 590n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
In vitro kinase assay using human Mnk1 and Mnk2.


US Patent US8486953 (2013)


BindingDB Entry DOI: 10.7270/Q2TM78R3
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176773
PNG
(US9675612, 16 N-(1H-Indazol-5-yl)[1,3]thiazolo[5,4...)
Show SMILES N(c1ccc2[nH]ncc2c1)c1ncnc2scnc12
Show InChI InChI=1S/C12H8N6S/c1-2-9-7(4-16-18-9)3-8(1)17-11-10-12(14-5-13-11)19-6-15-10/h1-6H,(H,16,18)(H,13,14,17)
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n/an/a 186n/an/an/an/a7.5n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176774
PNG
(US9675612, 17 2-(2-Phenylethyl)-N-[6-(propan-2-ylo...)
Show SMILES CC(C)Oc1cc2[nH]ncc2cc1Nc1ncnc2sc(CCc3ccccc3)nc12
Show InChI InChI=1S/C23H22N6OS/c1-14(2)30-19-11-17-16(12-26-29-17)10-18(19)27-22-21-23(25-13-24-22)31-20(28-21)9-8-15-6-4-3-5-7-15/h3-7,10-14H,8-9H2,1-2H3,(H,26,29)(H,24,25,27)
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n/an/a 229n/an/an/an/a7.5n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176775
PNG
(US9675612, 18 5-Methoxy-6-([1,3]thiazolo[5,4-d]pyr...)
Show SMILES COc1cc2[nH]c(=O)sc2cc1Nc1ncnc2scnc12
Show InChI InChI=1S/C13H9N5O2S2/c1-20-8-2-7-9(22-13(19)18-7)3-6(8)17-11-10-12(15-4-14-11)21-5-16-10/h2-5H,1H3,(H,18,19)(H,14,15,17)
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n/an/a 104n/an/an/an/a7.5n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176776
PNG
(US9675612, 19 6-([1,3]Thiazolo[5,4-d]pyrimidin-7-y...)
Show SMILES O=c1[nH]c2ccc(Nc3ncnc4scnc34)cc2s1
Show InChI InChI=1S/C12H7N5OS2/c18-12-17-7-2-1-6(3-8(7)20-12)16-10-9-11(14-4-13-10)19-5-15-9/h1-5H,(H,17,18)(H,13,14,16)
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n/an/a 159n/an/an/an/a7.5n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176777
PNG
(US9675612, 20 2-[(Benzyloxy)methyl]-N-(6-methoxy-1...)
Show SMILES COc1cc2[nH]ncc2cc1Nc1ncnc2sc(COCc3ccccc3)nc12
Show InChI InChI=1S/C21H18N6O2S/c1-28-17-8-15-14(9-24-27-15)7-16(17)25-20-19-21(23-12-22-20)30-18(26-19)11-29-10-13-5-3-2-4-6-13/h2-9,12H,10-11H2,1H3,(H,24,27)(H,22,23,25)
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n/an/a 36n/an/an/an/a7.5n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176778
PNG
(US9675612, 21 3-[7-(1H-Indazol-5-ylamino)[1,3]thia...)
Show SMILES CN(C)C(=O)CCc1nc2c(Nc3ccc4[nH]ncc4c3)ncnc2s1
Show InChI InChI=1S/C17H17N7OS/c1-24(2)14(25)6-5-13-22-15-16(18-9-19-17(15)26-13)21-11-3-4-12-10(7-11)8-20-23-12/h3-4,7-9H,5-6H2,1-2H3,(H,20,23)(H,18,19,21)
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n/an/a 100n/an/an/an/a7.5n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176779
PNG
(US9675612, 22 N-(6-Methoxy-1H-indazol-5-yl)-2-(2-p...)
Show SMILES COc1cc2[nH]ncc2cc1Nc1ncnc2sc(CCc3ccccc3)nc12
Show InChI InChI=1S/C21H18N6OS/c1-28-17-10-15-14(11-24-27-15)9-16(17)25-20-19-21(23-12-22-20)29-18(26-19)8-7-13-5-3-2-4-6-13/h2-6,9-12H,7-8H2,1H3,(H,24,27)(H,22,23,25)
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n/an/a 38n/an/an/an/a7.5n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176780
PNG
(US9675612, 23 N-(1H-indazol-5-yl)-2-(2-phenylethyl...)
Show SMILES C(Cc1ccccc1)c1nc2c(Nc3ccc4[nH]ncc4c3)ncnc2s1
Show InChI InChI=1S/C20H16N6S/c1-2-4-13(5-3-1)6-9-17-25-18-19(21-12-22-20(18)27-17)24-15-7-8-16-14(10-15)11-23-26-16/h1-5,7-8,10-12H,6,9H2,(H,23,26)(H,21,22,24)
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n/an/a 51n/an/an/an/a7.5n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176782
PNG
(US9675612, 25 5-Methoxy-6-{[2-(2-phenylethyl)[1,3]...)
Show SMILES COc1cc2[nH]c(=O)sc2cc1Nc1ncnc2sc(CCc3ccccc3)nc12
Show InChI InChI=1S/C21H17N5O2S2/c1-28-15-9-14-16(29-21(27)25-14)10-13(15)24-19-18-20(23-11-22-19)30-17(26-18)8-7-12-5-3-2-4-6-12/h2-6,9-11H,7-8H2,1H3,(H,25,27)(H,22,23,24)
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n/an/a 1.00E+4n/an/an/an/a7.5n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176783
PNG
(US9675612, 26 4-{7-[(6-Methoxy-1H-indazol-5-yl)ami...)
Show SMILES COc1cc2[nH]ncc2cc1Nc1ncnc2sc(CCCC(=O)N(C)C)nc12
Show InChI InChI=1S/C19H21N7O2S/c1-26(2)16(27)6-4-5-15-24-17-18(20-10-21-19(17)29-15)23-13-7-11-9-22-25-12(11)8-14(13)28-3/h7-10H,4-6H2,1-3H3,(H,22,25)(H,20,21,23)
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n/an/a 85n/an/an/an/a7.5n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176784
PNG
(US9675612, 27 N,N-Dimethyl-7-[(2-oxo-2,3-dihydro-1...)
Show SMILES CN(C)C(=O)c1nc2c(Nc3ccc4[nH]c(=O)sc4c3)ncnc2s1
Show InChI InChI=1S/C15H12N6O2S2/c1-21(2)14(22)13-20-10-11(16-6-17-12(10)25-13)18-7-3-4-8-9(5-7)24-15(23)19-8/h3-6H,1-2H3,(H,19,23)(H,16,17,18)
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n/an/a 408n/an/an/an/a7.5n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176785
PNG
(US9675612, 28 7-[(5-Methoxy-2-oxo-2,3-dihydro-1,3-...)
Show SMILES COc1cc2[nH]c(=O)sc2cc1Nc1ncnc2sc(nc12)C(=O)N(C)C
Show InChI InChI=1S/C16H14N6O3S2/c1-22(2)15(23)14-21-11-12(17-6-18-13(11)27-14)19-7-5-10-8(4-9(7)25-3)20-16(24)26-10/h4-6H,1-3H3,(H,20,24)(H,17,18,19)
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n/an/a 1.08E+3n/an/an/an/a7.5n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176790
PNG
(US9675612, 29 7-[(6-Methoxy-1H-indazol-5-yl)amino]...)
Show SMILES COc1cc2[nH]ncc2cc1Nc1ncnc2sc(nc12)C(=O)N(C)C
Show InChI InChI=1S/C16H15N7O2S/c1-23(2)16(24)15-21-12-13(17-7-18-14(12)26-15)20-10-4-8-6-19-22-9(8)5-11(10)25-3/h4-7H,1-3H3,(H,19,22)(H,17,18,20)
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n/an/a 199n/an/an/an/a7.5n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176791
PNG
(US9675612, 30 7-[(6-Ethoxy-1H-indazol-5-yl)amino]-...)
Show SMILES CCOc1cc2[nH]ncc2cc1Nc1ncnc2sc(nc12)C(=O)N(C)C
Show InChI InChI=1S/C17H17N7O2S/c1-4-26-12-6-10-9(7-20-23-10)5-11(12)21-14-13-15(19-8-18-14)27-16(22-13)17(25)24(2)3/h5-8H,4H2,1-3H3,(H,20,23)(H,18,19,21)
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n/an/a 42n/an/an/an/a7.5n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176793
PNG
(US9675612, 31 [7-(1H-Indazol-5-ylamino)[1,3]thiazo...)
Show SMILES O=C(N1CCCCC1)c1nc2c(Nc3ccc4[nH]ncc4c3)ncnc2s1
Show InChI InChI=1S/C18H17N7OS/c26-18(25-6-2-1-3-7-25)17-23-14-15(19-10-20-16(14)27-17)22-12-4-5-13-11(8-12)9-21-24-13/h4-5,8-10H,1-3,6-7H2,(H,21,24)(H,19,20,22)
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n/an/a 188n/an/an/an/a7.5n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176794
PNG
(US9675612, 32 6-{[2-(Piperidin-1-ylcarbonyl)[1,3]t...)
Show SMILES O=C(N1CCCCC1)c1nc2c(Nc3ccc4[nH]c(=O)sc4c3)ncnc2s1
Show InChI InChI=1S/C18H16N6O2S2/c25-17(24-6-2-1-3-7-24)16-23-13-14(19-9-20-15(13)28-16)21-10-4-5-11-12(8-10)27-18(26)22-11/h4-5,8-9H,1-3,6-7H2,(H,22,26)(H,19,20,21)
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n/an/a 137n/an/an/an/a7.5n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176795
PNG
(US9675612, 33 {7-[(6-Methoxy-1H-indazol-5-yl)amino...)
Show SMILES COc1cc2[nH]ncc2cc1Nc1ncnc2sc(nc12)C(=O)N1CCCCC1
Show InChI InChI=1S/C19H19N7O2S/c1-28-14-8-12-11(9-22-25-12)7-13(14)23-16-15-17(21-10-20-16)29-18(24-15)19(27)26-5-3-2-4-6-26/h7-10H,2-6H2,1H3,(H,22,25)(H,20,21,23)
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n/an/a 17n/an/an/an/a7.5n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176796
PNG
(US9675612, 34 {7-[(6-Ethoxy-1H-indazol-5-yl)amino]...)
Show SMILES CCOc1cc2[nH]ncc2cc1Nc1ncnc2sc(nc12)C(=O)N1CCCCC1
Show InChI InChI=1S/C20H21N7O2S/c1-2-29-15-9-13-12(10-23-26-13)8-14(15)24-17-16-18(22-11-21-17)30-19(25-16)20(28)27-6-4-3-5-7-27/h8-11H,2-7H2,1H3,(H,23,26)(H,21,22,24)
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n/an/a 34n/an/an/an/a7.5n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176798
PNG
(US9675612, 35 Piperidin-1-yl(7-{[6-(propan-2-yloxy...)
Show SMILES CC(C)Oc1cc2[nH]ncc2cc1Nc1ncnc2sc(nc12)C(=O)N1CCCCC1
Show InChI InChI=1S/C21H23N7O2S/c1-12(2)30-16-9-14-13(10-24-27-14)8-15(16)25-18-17-19(23-11-22-18)31-20(26-17)21(29)28-6-4-3-5-7-28/h8-12H,3-7H2,1-2H3,(H,24,27)(H,22,23,25)
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n/an/a 102n/an/an/an/a7.5n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176799
PNG
(US9675612, 36 N-[2-(Dimethylamino)-2-oxoethyl]-7-(...)
Show SMILES CN(C)C(=O)CN(C)C(=O)c1nc2c(Nc3ccc4[nH]ncc4c3)ncnc2s1
Show InChI InChI=1S/C18H18N8O2S/c1-25(2)13(27)8-26(3)18(28)17-23-14-15(19-9-20-16(14)29-17)22-11-4-5-12-10(6-11)7-21-24-12/h4-7,9H,8H2,1-3H3,(H,21,24)(H,19,20,22)
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n/an/a 81n/an/an/an/a7.5n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176800
PNG
(US9675612, 37 N-[2-(Dimethylamino)-2-oxoethyl]-N-m...)
Show SMILES CN(C)C(=O)CN(C)C(=O)c1nc2c(Nc3ccc4[nH]c(=O)sc4c3)ncnc2s1
Show InChI InChI=1S/C18H17N7O3S2/c1-24(2)12(26)7-25(3)17(27)16-23-13-14(19-8-20-15(13)30-16)21-9-4-5-10-11(6-9)29-18(28)22-10/h4-6,8H,7H2,1-3H3,(H,22,28)(H,19,20,21)
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n/an/a 445n/an/an/an/a7.5n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176801
PNG
(US9675612, 38 N-[2-(Dimethylamino)-2-oxoethyl]-7-[...)
Show SMILES COc1cc2[nH]ncc2cc1Nc1ncnc2sc(nc12)C(=O)N(C)CC(=O)N(C)C
Show InChI InChI=1S/C19H20N8O3S/c1-26(2)14(28)8-27(3)19(29)18-24-15-16(20-9-21-17(15)31-18)23-12-5-10-7-22-25-11(10)6-13(12)30-4/h5-7,9H,8H2,1-4H3,(H,22,25)(H,20,21,23)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176802
PNG
(US9675612, 39 N-[2-(Dimethylamino)-2-oxoethyl]-N-m...)
Show SMILES CC(C)Oc1cc2[nH]ncc2cc1Nc1ncnc2sc(nc12)C(=O)N(C)CC(=O)N(C)C
Show InChI InChI=1S/C21H24N8O3S/c1-11(2)32-15-7-13-12(8-24-27-13)6-14(15)25-18-17-19(23-10-22-18)33-20(26-17)21(31)29(5)9-16(30)28(3)4/h6-8,10-11H,9H2,1-5H3,(H,24,27)(H,22,23,25)
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n/an/a 98n/an/an/an/a7.5n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176803
PNG
(US9675612, 40 N-[3-(Dimethylamino)-3-oxopropyl]-7-...)
Show SMILES CN(C)C(=O)CCN(C)C(=O)c1nc2c(Nc3ccc4[nH]ncc4c3)ncnc2s1
Show InChI InChI=1S/C19H20N8O2S/c1-26(2)14(28)6-7-27(3)19(29)18-24-15-16(20-10-21-17(15)30-18)23-12-4-5-13-11(8-12)9-22-25-13/h4-5,8-10H,6-7H2,1-3H3,(H,22,25)(H,20,21,23)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176804
PNG
(US9675612, 41 N-[3-(Dimethylamino)-3-oxopropyl]-N-...)
Show SMILES CN(C)C(=O)CCN(C)C(=O)c1nc2c(Nc3ccc4[nH]c(=O)sc4c3)ncnc2s1
Show InChI InChI=1S/C19H19N7O3S2/c1-25(2)13(27)6-7-26(3)18(28)17-24-14-15(20-9-21-16(14)31-17)22-10-4-5-11-12(8-10)30-19(29)23-11/h4-5,8-9H,6-7H2,1-3H3,(H,23,29)(H,20,21,22)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176805
PNG
(US9675612, 42 N-[3-(Dimethylamino)-3-oxopropyl]-7-...)
Show SMILES CCOc1cc2[nH]ncc2cc1Nc1ncnc2sc(nc12)C(=O)N(C)CCC(=O)N(C)C
Show InChI InChI=1S/C21H24N8O3S/c1-5-32-15-9-13-12(10-24-27-13)8-14(15)25-18-17-19(23-11-22-18)33-20(26-17)21(31)29(4)7-6-16(30)28(2)3/h8-11H,5-7H2,1-4H3,(H,24,27)(H,22,23,25)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176806
PNG
(US9675612, 43 7-(1H-Indazol-5-ylamino)-N,N-dimethy...)
Show SMILES CN(C)C(=O)c1nc2c(Nc3ccc4[nH]ncc4c3)ncnc2s1
Show InChI InChI=1S/C15H13N7OS/c1-22(2)15(23)14-20-11-12(16-7-17-13(11)24-14)19-9-3-4-10-8(5-9)6-18-21-10/h3-7H,1-2H3,(H,18,21)(H,16,17,19)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176807
PNG
(US9675612, 44 N,N-Dimethyl-7-{[6-(propan-2-yloxy)-...)
Show SMILES CC(C)Oc1cc2[nH]ncc2cc1Nc1ncnc2sc(nc12)C(=O)N(C)C
Show InChI InChI=1S/C18H19N7O2S/c1-9(2)27-13-6-11-10(7-21-24-11)5-12(13)22-15-14-16(20-8-19-15)28-17(23-14)18(26)25(3)4/h5-9H,1-4H3,(H,21,24)(H,19,20,22)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176808
PNG
(US9675612, 45 N-[2-(Dimethylamino)-2-oxoethyl]-7-[...)
Show SMILES CCOc1cc2[nH]ncc2cc1Nc1ncnc2sc(nc12)C(=O)N(C)CC(=O)N(C)C
Show InChI InChI=1S/C20H22N8O3S/c1-5-31-14-7-12-11(8-23-26-12)6-13(14)24-17-16-18(22-10-21-17)32-19(25-16)20(30)28(4)9-15(29)27(2)3/h6-8,10H,5,9H2,1-4H3,(H,23,26)(H,21,22,24)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176810
PNG
(US9675612, 46 N-[3-(Dimethylamino)-3-oxopropyl]-7-...)
Show SMILES COc1cc2[nH]ncc2cc1Nc1ncnc2sc(nc12)C(=O)N(C)CCC(=O)N(C)C
Show InChI InChI=1S/C20H22N8O3S/c1-27(2)15(29)5-6-28(3)20(30)19-25-16-17(21-10-22-18(16)32-19)24-13-7-11-9-23-26-12(11)8-14(13)31-4/h7-10H,5-6H2,1-4H3,(H,23,26)(H,21,22,24)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM176814
PNG
(US9675612, 47 N-[3-(Dimethylamino)-3-oxopropyl]-7-...)
Show SMILES CC(C)Oc1cc2[nH]ncc2cc1Nc1ncnc2sc(nc12)C(=O)N(C)CCC(=O)N(C)C
Show InChI InChI=1S/C22H26N8O3S/c1-12(2)33-16-9-14-13(10-25-28-14)8-15(16)26-19-18-20(24-11-23-19)34-21(27-18)22(32)30(5)7-6-17(31)29(3)4/h8-12H,6-7H2,1-5H3,(H,25,28)(H,23,24,26)
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US Patent
n/an/a 32n/an/an/an/a7.5n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9675612 (2017)


BindingDB Entry DOI: 10.7270/Q2RN3612
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM181380
PNG
(US9139577, 1.011 | US9708274, 1.011)
Show SMILES Cc1cc(cc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c12)N=S1(=O)CCCC1
Show InChI InChI=1S/C22H23F3N4O2S/c1-14-8-16(29-32(30)6-2-3-7-32)10-19-21(14)22(27-13-26-19)28-18-5-4-15(25)9-20(18)31-17(11-23)12-24/h4-5,8-10,13,17H,2-3,6-7,11-12H2,1H3,(H,26,27,28)
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n/an/a 34n/an/an/an/a7.5n/a



EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK1a was assessed using pre-activated GST-MNK1a. The 2xMKNK1 (MNK1) mixture is prepared in 50 mM HEPES pH 7.5, ...


US Patent US9708274 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM181385
PNG
(US9139577, 1.016 | US9708274, 1.016)
Show SMILES C[C@@H](Oc1ncccc1Nc1ncnc2cc(cc(Cl)c12)N=S(C)(C)=O)c1cc(C)no1
Show InChI InChI=1S/C21H21ClN6O3S/c1-12-8-18(31-27-12)13(2)30-21-16(6-5-7-23-21)26-20-19-15(22)9-14(28-32(3,4)29)10-17(19)24-11-25-20/h5-11,13H,1-4H3,(H,24,25,26)/t13-/m1/s1
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n/an/a 53n/an/an/an/a7.5n/a



EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK1a was assessed using pre-activated GST-MNK1a. The 2xMKNK1 (MNK1) mixture is prepared in 50 mM HEPES pH 7.5, ...


US Patent US9708274 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM181388
PNG
(US9139577, 1.019 | US9708274, 1.019)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(Cl)c12)N=S(C)(C)=O)c1cc(C)no1
Show InChI InChI=1S/C22H21ClFN5O3S/c1-12-7-19(32-28-12)13(2)31-20-8-14(24)5-6-17(20)27-22-21-16(23)9-15(29-33(3,4)30)10-18(21)25-11-26-22/h5-11,13H,1-4H3,(H,25,26,27)/t13-/m1/s1
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n/an/a 54n/an/an/an/a7.5n/a



EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK1a was assessed using pre-activated GST-MNK1a. The 2xMKNK1 (MNK1) mixture is prepared in 50 mM HEPES pH 7.5, ...


US Patent US9708274 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM181393
PNG
(US9139577, 2.001 | US9708274, 2.001)
Show SMILES CC(Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCCC1)C(C)(C)O
Show InChI InChI=1S/C24H29FN4O3S/c1-15-11-18(29-33(31)9-5-6-10-33)13-20-22(15)23(27-14-26-20)28-19-8-7-17(25)12-21(19)32-16(2)24(3,4)30/h7-8,11-14,16,30H,5-6,9-10H2,1-4H3,(H,26,27,28)
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n/an/a 228n/an/an/an/a7.5n/a



EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK1a was assessed using pre-activated GST-MNK1a. The 2xMKNK1 (MNK1) mixture is prepared in 50 mM HEPES pH 7.5, ...


US Patent US9708274 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM181398
PNG
(US9139577, 2.006 | US9708274, 2.006)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCC1)C(F)(F)F
Show InChI InChI=1S/C21H20F4N4O2S/c1-12-8-15(29-32(30)6-3-7-32)10-17-19(12)20(27-11-26-17)28-16-5-4-14(22)9-18(16)31-13(2)21(23,24)25/h4-5,8-11,13H,3,6-7H2,1-2H3,(H,26,27,28)/t13-/m1/s1
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n/an/a 71n/an/an/an/a7.5n/a



EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK1a was assessed using pre-activated GST-MNK1a. The 2xMKNK1 (MNK1) mixture is prepared in 50 mM HEPES pH 7.5, ...


US Patent US9708274 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM181400
PNG
(US9139577, 2.008 | US9708274, 2.008)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S(C)(C)=O)c1cc(C)no1
Show InChI InChI=1S/C23H24FN5O3S/c1-13-8-17(29-33(4,5)30)11-19-22(13)23(26-12-25-19)27-18-7-6-16(24)10-21(18)31-15(3)20-9-14(2)28-32-20/h6-12,15H,1-5H3,(H,25,26,27)/t15-/m1/s1
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n/an/a 25n/an/an/an/a7.5n/a



EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK1a was assessed using pre-activated GST-MNK1a. The 2xMKNK1 (MNK1) mixture is prepared in 50 mM HEPES pH 7.5, ...


US Patent US9708274 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM181401
PNG
(US9139577, 2.009 | US9708274, 2.009)
Show SMILES C[C@@H](Oc1ncccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCCC1)c1cc(C)no1
Show InChI InChI=1S/C24H26N6O3S/c1-15-11-18(30-34(31)9-4-5-10-34)13-20-22(15)23(27-14-26-20)28-19-7-6-8-25-24(19)32-17(3)21-12-16(2)29-33-21/h6-8,11-14,17H,4-5,9-10H2,1-3H3,(H,26,27,28)/t17-/m1/s1
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n/an/a 49n/an/an/an/a7.5n/a



EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK1a was assessed using pre-activated GST-MNK1a. The 2xMKNK1 (MNK1) mixture is prepared in 50 mM HEPES pH 7.5, ...


US Patent US9708274 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM181410
PNG
(US9139577, 2.018 | US9708274, 2.018)
Show SMILES C[C@@H](Oc1ncccc1Nc1ncnc2cc(cc(C)c12)N=S(C)(C)=O)c1cc(C)no1
Show InChI InChI=1S/C22H24N6O3S/c1-13-9-16(28-32(4,5)29)11-18-20(13)21(25-12-24-18)26-17-7-6-8-23-22(17)30-15(3)19-10-14(2)27-31-19/h6-12,15H,1-5H3,(H,24,25,26)/t15-/m1/s1
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n/an/a 34n/an/an/an/a7.5n/a



EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK1a was assessed using pre-activated GST-MNK1a. The 2xMKNK1 (MNK1) mixture is prepared in 50 mM HEPES pH 7.5, ...


US Patent US9708274 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM181439
PNG
(US9139577, 2.048 | US9708274, 2.048)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCCC1)C(F)(F)F
Show InChI InChI=1S/C22H22F4N4O2S/c1-13-9-16(30-33(31)7-3-4-8-33)11-18-20(13)21(28-12-27-18)29-17-6-5-15(23)10-19(17)32-14(2)22(24,25)26/h5-6,9-12,14H,3-4,7-8H2,1-2H3,(H,27,28,29)/t14-/m1/s1
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n/an/a 40n/an/an/an/a7.5n/a



EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK1a was assessed using pre-activated GST-MNK1a. The 2xMKNK1 (MNK1) mixture is prepared in 50 mM HEPES pH 7.5, ...


US Patent US9708274 (2017)

More data for this
Ligand-Target Pair
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