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Found 1558 hits Enz. Inhib. hit(s) with Target = 'MAP kinase-interacting serine/threonine-protein kinase 2'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136224
PNG
(US8853193, 33-4)
Show SMILES Cc1c(sc2ncnc(Nc3cccnc3OCC3(CC#N)CC3)c12)C(N)=O
Show InChI InChI=1S/C19H18N6O2S/c1-11-13-16(23-10-24-18(13)28-14(11)15(21)26)25-12-3-2-8-22-17(12)27-9-19(4-5-19)6-7-20/h2-3,8,10H,4-6,9H2,1H3,(H2,21,26)(H,23,24,25)
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US Patent
n/an/a 16n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136225
PNG
(US8853193, 34)
Show SMILES COC(=O)c1sc2ncnc(Nc3cccnc3OCC3CC3(F)F)c2c1C
Show InChI InChI=1S/C18H16F2N4O3S/c1-9-12-14(22-8-23-16(12)28-13(9)17(25)26-2)24-11-4-3-5-21-15(11)27-7-10-6-18(10,19)20/h3-5,8,10H,6-7H2,1-2H3,(H,22,23,24)
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US Patent
n/an/a 54n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136226
PNG
(US8853193, 34-4)
Show SMILES Cc1c(sc2ncnc(Nc3cccnc3OCC3CC3(F)F)c12)C(N)=O
Show InChI InChI=1S/C17H15F2N5O2S/c1-8-11-14(22-7-23-16(11)27-12(8)13(20)25)24-10-3-2-4-21-15(10)26-6-9-5-17(9,18)19/h2-4,7,9H,5-6H2,1H3,(H2,20,25)(H,22,23,24)
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n/an/a 15n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136227
PNG
(US8853193, 35)
Show SMILES COC(=O)c1sc2ncnc(Nc3cccnc3OC(C)C)c2c1C
Show InChI InChI=1S/C17H18N4O3S/c1-9(2)24-15-11(6-5-7-18-15)21-14-12-10(3)13(17(22)23-4)25-16(12)20-8-19-14/h5-9H,1-4H3,(H,19,20,21)
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n/an/a 12n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136228
PNG
(US8853193, 36)
Show SMILES CC(C)Oc1ncccc1Nc1ncnc2sc(C(=O)NCCCN(C)C)c(C)c12
Show InChI InChI=1S/C21H28N6O2S/c1-13(2)29-20-15(8-6-9-23-20)26-18-16-14(3)17(30-21(16)25-12-24-18)19(28)22-10-7-11-27(4)5/h6,8-9,12-13H,7,10-11H2,1-5H3,(H,22,28)(H,24,25,26)
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n/an/a 29n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136229
PNG
(US8853193, 36-1)
Show SMILES CC(C)Oc1ncccc1Nc1ncnc2sc(C(=O)NCCCN3CCCC3)c(C)c12
Show InChI InChI=1S/C23H30N6O2S/c1-15(2)31-22-17(8-6-9-25-22)28-20-18-16(3)19(32-23(18)27-14-26-20)21(30)24-10-7-13-29-11-4-5-12-29/h6,8-9,14-15H,4-5,7,10-13H2,1-3H3,(H,24,30)(H,26,27,28)
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n/an/a 35n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136231
PNG
(US8853193, 36-3)
Show SMILES CCNC(=O)c1sc2ncnc(Nc3cccnc3OC(C)C)c2c1C
Show InChI InChI=1S/C18H21N5O2S/c1-5-19-16(24)14-11(4)13-15(21-9-22-18(13)26-14)23-12-7-6-8-20-17(12)25-10(2)3/h6-10H,5H2,1-4H3,(H,19,24)(H,21,22,23)
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n/an/a 26n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136232
PNG
(US8853193, 36-4)
Show SMILES CC(C)Oc1ncccc1Nc1ncnc2sc(C(=O)NCCCN3CCOCC3)c(C)c12
Show InChI InChI=1S/C23H30N6O3S/c1-15(2)32-22-17(6-4-7-25-22)28-20-18-16(3)19(33-23(18)27-14-26-20)21(30)24-8-5-9-29-10-12-31-13-11-29/h4,6-7,14-15H,5,8-13H2,1-3H3,(H,24,30)(H,26,27,28)
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n/an/a 44n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136233
PNG
(US8853193, 36-5)
Show SMILES CC(C)Oc1ncccc1Nc1ncnc2sc(C(=O)NCC3CNCCO3)c(C)c12
Show InChI InChI=1S/C21H26N6O3S/c1-12(2)30-20-15(5-4-6-23-20)27-18-16-13(3)17(31-21(16)26-11-25-18)19(28)24-10-14-9-22-7-8-29-14/h4-6,11-12,14,22H,7-10H2,1-3H3,(H,24,28)(H,25,26,27)
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n/an/a 25n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136234
PNG
(US8853193, 36-6)
Show SMILES CC(C)Oc1ncccc1Nc1ncnc2sc(C(=O)N[C@H]3C[C@@H]3N)c(C)c12
Show InChI InChI=1S/C19H22N6O2S/c1-9(2)27-18-12(5-4-6-21-18)24-16-14-10(3)15(28-19(14)23-8-22-16)17(26)25-13-7-11(13)20/h4-6,8-9,11,13H,7,20H2,1-3H3,(H,25,26)(H,22,23,24)/t11-,13-/m0/s1
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n/an/a 55n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136236
PNG
(US8853193, 36-8)
Show SMILES CC(C)Oc1ncccc1Nc1ncnc2sc(C(=O)NCc3cnco3)c(C)c12
Show InChI InChI=1S/C20H20N6O3S/c1-11(2)29-19-14(5-4-6-22-19)26-17-15-12(3)16(30-20(15)25-9-24-17)18(27)23-8-13-7-21-10-28-13/h4-7,9-11H,8H2,1-3H3,(H,23,27)(H,24,25,26)
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n/an/a 19n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136237
PNG
(US8853193, 36-9)
Show SMILES CC(C)Oc1ncccc1Nc1ncnc2sc(C(=O)NCCN3CCCCC3)c(C)c12
Show InChI InChI=1S/C23H30N6O2S/c1-15(2)31-22-17(8-7-9-25-22)28-20-18-16(3)19(32-23(18)27-14-26-20)21(30)24-10-13-29-11-5-4-6-12-29/h7-9,14-15H,4-6,10-13H2,1-3H3,(H,24,30)(H,26,27,28)
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n/an/a 63n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136238
PNG
(US8853193, 36-10)
Show SMILES CC(C)Oc1ncccc1Nc1ncnc2sc(C(=O)NC3CCN(C)CC3)c(C)c12
Show InChI InChI=1S/C22H28N6O2S/c1-13(2)30-21-16(6-5-9-23-21)27-19-17-14(3)18(31-22(17)25-12-24-19)20(29)26-15-7-10-28(4)11-8-15/h5-6,9,12-13,15H,7-8,10-11H2,1-4H3,(H,26,29)(H,24,25,27)
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n/an/a 32n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136239
PNG
(US8853193, 36-11)
Show SMILES CC(C)Oc1ncccc1Nc1ncnc2sc(C(=O)NCCCO)c(C)c12
Show InChI InChI=1S/C19H23N5O3S/c1-11(2)27-18-13(6-4-7-21-18)24-16-14-12(3)15(17(26)20-8-5-9-25)28-19(14)23-10-22-16/h4,6-7,10-11,25H,5,8-9H2,1-3H3,(H,20,26)(H,22,23,24)
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n/an/a 45n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136241
PNG
(US8853193, 36-13)
Show SMILES CC(C)Oc1ncccc1Nc1ncnc2sc(C(=O)NCC(C)O)c(C)c12
Show InChI InChI=1S/C19H23N5O3S/c1-10(2)27-18-13(6-5-7-20-18)24-16-14-12(4)15(17(26)21-8-11(3)25)28-19(14)23-9-22-16/h5-7,9-11,25H,8H2,1-4H3,(H,21,26)(H,22,23,24)
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n/an/a 54n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136242
PNG
(US8853193, 36-14)
Show SMILES CC(C)Oc1ncccc1Nc1ncnc2sc(C(=O)NCC3COCCN3)c(C)c12
Show InChI InChI=1S/C21H26N6O3S/c1-12(2)30-20-15(5-4-6-23-20)27-18-16-13(3)17(31-21(16)26-11-25-18)19(28)24-9-14-10-29-8-7-22-14/h4-6,11-12,14,22H,7-10H2,1-3H3,(H,24,28)(H,25,26,27)
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n/an/a 64n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136243
PNG
(US8853193, 36-15)
Show SMILES CC(C)Oc1ncccc1Nc1ncnc2sc(C(=O)NCc3cn(C)cn3)c(C)c12
Show InChI InChI=1S/C21H23N7O2S/c1-12(2)30-20-15(6-5-7-22-20)27-18-16-13(3)17(31-21(16)25-10-24-18)19(29)23-8-14-9-28(4)11-26-14/h5-7,9-12H,8H2,1-4H3,(H,23,29)(H,24,25,27)
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n/an/a 24n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136244
PNG
(US8853193, 36-16)
Show SMILES CC(C)Oc1ncccc1Nc1ncnc2sc(C(=O)NCC#CCN(C)C)c(C)c12
Show InChI InChI=1S/C22H26N6O2S/c1-14(2)30-21-16(9-8-11-24-21)27-19-17-15(3)18(31-22(17)26-13-25-19)20(29)23-10-6-7-12-28(4)5/h8-9,11,13-14H,10,12H2,1-5H3,(H,23,29)(H,25,26,27)
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n/an/a 22n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136245
PNG
(US8853193, 36-17)
Show SMILES CC(C)Oc1ncccc1Nc1ncnc2sc(C(=O)N[C@H]3CC[C@H](O)CC3)c(C)c12
Show InChI InChI=1S/C22H27N5O3S/c1-12(2)30-21-16(5-4-10-23-21)27-19-17-13(3)18(31-22(17)25-11-24-19)20(29)26-14-6-8-15(28)9-7-14/h4-5,10-12,14-15,28H,6-9H2,1-3H3,(H,26,29)(H,24,25,27)/t14-,15-
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n/an/a 46n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136247
PNG
(US8853193, 36-19)
Show SMILES CC(C)Oc1ncccc1Nc1ncnc2sc(C(=O)NCC#CCN)c(C)c12
Show InChI InChI=1S/C20H22N6O2S/c1-12(2)28-19-14(7-6-10-23-19)26-17-15-13(3)16(29-20(15)25-11-24-17)18(27)22-9-5-4-8-21/h6-7,10-12H,8-9,21H2,1-3H3,(H,22,27)(H,24,25,26)
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n/an/a 14n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM98036
PNG
(US8486953, 19)
Show SMILES COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C)c2c1C
Show InChI InChI=1S/C18H18FN3O3S/c1-9(2)25-13-7-11(19)5-6-12(13)22-16-14-10(3)15(18(23)24-4)26-17(14)21-8-20-16/h5-9H,1-4H3,(H,20,21,22)
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n/an/a 4n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM98040
PNG
(US8486953, 53)
Show SMILES CC(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)NCCCN(C)C)c(C)c12
Show InChI InChI=1S/C22H28FN5O2S/c1-13(2)30-17-11-15(23)7-8-16(17)27-20-18-14(3)19(31-22(18)26-12-25-20)21(29)24-9-6-10-28(4)5/h7-8,11-13H,6,9-10H2,1-5H3,(H,24,29)(H,25,26,27)
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n/an/a 6n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136218
PNG
(US8853193, 31-4 | US8853193, 39)
Show SMILES CCNC(=O)C(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(O)=O)c(C)c12
Show InChI InChI=1S/C19H19FN4O4S/c1-4-21-17(25)10(3)28-13-7-11(20)5-6-12(13)24-16-14-9(2)15(19(26)27)29-18(14)23-8-22-16/h5-8,10H,4H2,1-3H3,(H,21,25)(H,26,27)(H,22,23,24)
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n/an/a 19n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136250
PNG
(US8853193, 41)
Show SMILES CCNC(=O)C(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)NCCO)c(C)c12
Show InChI InChI=1S/C21H24FN5O4S/c1-4-23-19(29)12(3)31-15-9-13(22)5-6-14(15)27-18-16-11(2)17(20(30)24-7-8-28)32-21(16)26-10-25-18/h5-6,9-10,12,28H,4,7-8H2,1-3H3,(H,23,29)(H,24,30)(H,25,26,27)
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n/an/a 31n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136251
PNG
(US8853193, 42)
Show SMILES CC(CCN)Oc1ncccc1Nc1ncnc2sc(C(=O)NCCO)c(C)c12
Show InChI InChI=1S/C19H24N6O3S/c1-11(5-6-20)28-18-13(4-3-7-22-18)25-16-14-12(2)15(17(27)21-8-9-26)29-19(14)24-10-23-16/h3-4,7,10-11,26H,5-6,8-9,20H2,1-2H3,(H,21,27)(H,23,24,25)
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n/an/a 70n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136252
PNG
(US8853193, 43)
Show SMILES CC(CCNS(C)(=O)=O)Oc1ncccc1Nc1ncnc2sc(C(=O)NCCO)c(C)c12
Show InChI InChI=1S/C20H26N6O5S2/c1-12(6-8-25-33(3,29)30)31-19-14(5-4-7-22-19)26-17-15-13(2)16(18(28)21-9-10-27)32-20(15)24-11-23-17/h4-5,7,11-12,25,27H,6,8-10H2,1-3H3,(H,21,28)(H,23,24,26)
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n/an/a 62n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136253
PNG
(US8853193, 44)
Show SMILES CC(CCNS(C)(=O)=O)Oc1ncccc1Nc1ncnc2sc(C(O)=O)c(C)c12
Show InChI InChI=1S/C18H21N5O5S2/c1-10(6-8-22-30(3,26)27)28-16-12(5-4-7-19-16)23-15-13-11(2)14(18(24)25)29-17(13)21-9-20-15/h4-5,7,9-10,22H,6,8H2,1-3H3,(H,24,25)(H,20,21,23)
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n/an/a 24n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136255
PNG
(US8853193, 46)
Show SMILES CC(CCNS(C)(=O)=O)Oc1ncccc1Nc1ncnc2sc(C(=O)NCCCN(C)C)c(C)c12
Show InChI InChI=1S/C23H33N7O4S2/c1-15(9-12-28-36(5,32)33)34-22-17(8-6-10-25-22)29-20-18-16(2)19(35-23(18)27-14-26-20)21(31)24-11-7-13-30(3)4/h6,8,10,14-15,28H,7,9,11-13H2,1-5H3,(H,24,31)(H,26,27,29)
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n/an/a 84n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136256
PNG
(US8853193, 47)
Show SMILES COC(=O)c1sc2ncnc(Nc3ccc(cc3OC(CF)CF)C#N)c2c1C
Show InChI InChI=1S/C19H16F2N4O3S/c1-10-15-17(23-9-24-18(15)29-16(10)19(26)27-2)25-13-4-3-11(8-22)5-14(13)28-12(6-20)7-21/h3-5,9,12H,6-7H2,1-2H3,(H,23,24,25)
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n/an/a 125n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136257
PNG
(US8853193, 48)
Show SMILES Cc1c(sc2ncnc(Nc3ccc(cc3OC(CF)CF)C#N)c12)C(=O)NCCCN1CCCC1
Show InChI InChI=1S/C25H28F2N6O2S/c1-16-21-23(32-19-6-5-17(14-28)11-20(19)35-18(12-26)13-27)30-15-31-25(21)36-22(16)24(34)29-7-4-10-33-8-2-3-9-33/h5-6,11,15,18H,2-4,7-10,12-13H2,1H3,(H,29,34)(H,30,31,32)
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n/an/a 12n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136258
PNG
(US8853193, 49)
Show SMILES CN(C)CCCNC(=O)c1sc2ncnc(Nc3ccc(cc3OC(CF)CF)C#N)c2c1C
Show InChI InChI=1S/C23H26F2N6O2S/c1-14-19-21(30-17-6-5-15(12-26)9-18(17)33-16(10-24)11-25)28-13-29-23(19)34-20(14)22(32)27-7-4-8-31(2)3/h5-6,9,13,16H,4,7-8,10-11H2,1-3H3,(H,27,32)(H,28,29,30)
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n/an/a 8n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136259
PNG
(US8853193, 50)
Show SMILES CN1CCC(CC1)NC(=O)c1sc2ncnc(Nc3ccc(cc3OC(CF)CF)C#N)c2c1C
Show InChI InChI=1S/C24H26F2N6O2S/c1-14-20-22(31-18-4-3-15(12-27)9-19(18)34-17(10-25)11-26)28-13-29-24(20)35-21(14)23(33)30-16-5-7-32(2)8-6-16/h3-4,9,13,16-17H,5-8,10-11H2,1-2H3,(H,30,33)(H,28,29,31)
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n/an/a 13n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136261
PNG
(US8853193, 52)
Show SMILES CN(C)CC#CCNC(=O)c1sc2ncnc(Nc3ccc(cc3OC(CF)CF)C#N)c2c1C
Show InChI InChI=1S/C24H24F2N6O2S/c1-15-20-22(31-18-7-6-16(13-27)10-19(18)34-17(11-25)12-26)29-14-30-24(20)35-21(15)23(33)28-8-4-5-9-32(2)3/h6-7,10,14,17H,8-9,11-12H2,1-3H3,(H,28,33)(H,29,30,31)
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n/an/a 25n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136262
PNG
(US8853193, 53)
Show SMILES Cc1c(sc2ncnc(Nc3ccc(cc3OC(CF)CF)C#N)c12)C(=O)NCC#N
Show InChI InChI=1S/C20H16F2N6O2S/c1-11-16-18(26-10-27-20(16)31-17(11)19(29)25-5-4-23)28-14-3-2-12(9-24)6-15(14)30-13(7-21)8-22/h2-3,6,10,13H,5,7-8H2,1H3,(H,25,29)(H,26,27,28)
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n/an/a 7n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136263
PNG
(US8853193, 54)
Show SMILES CC(Oc1cc(F)ccc1Nc1ncnc2sc(C(N)=O)c(C)c12)C#N
Show InChI InChI=1S/C17H14FN5O2S/c1-8(6-19)25-12-5-10(18)3-4-11(12)23-16-13-9(2)14(15(20)24)26-17(13)22-7-21-16/h3-5,7-8H,1-2H3,(H2,20,24)(H,21,22,23)
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n/an/a 11n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136264
PNG
(US8853193, 55)
Show SMILES COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C(O)=O)c2c1C
Show InChI InChI=1S/C18H16FN3O5S/c1-8-13-15(20-7-21-16(13)28-14(8)18(25)26-3)22-11-5-4-10(19)6-12(11)27-9(2)17(23)24/h4-7,9H,1-3H3,(H,23,24)(H,20,21,22)
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n/an/a 5.40E+3n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136265
PNG
(US8853193, 56)
Show SMILES COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C(=O)NCCCN)c2c1C
Show InChI InChI=1S/C21H24FN5O4S/c1-11-16-18(25-10-26-20(16)32-17(11)21(29)30-3)27-14-6-5-13(22)9-15(14)31-12(2)19(28)24-8-4-7-23/h5-6,9-10,12H,4,7-8,23H2,1-3H3,(H,24,28)(H,25,26,27)
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n/an/a 314n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136266
PNG
(US8853193, 57)
Show SMILES CC(Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)NCCO)c(C)c12)C(=O)NCCCN
Show InChI InChI=1S/C22H27FN6O4S/c1-12-17-19(27-11-28-22(17)34-18(12)21(32)26-8-9-30)29-15-5-4-14(23)10-16(15)33-13(2)20(31)25-7-3-6-24/h4-5,10-11,13,30H,3,6-9,24H2,1-2H3,(H,25,31)(H,26,32)(H,27,28,29)
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n/an/a 110n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136267
PNG
(US8853193, 58)
Show SMILES COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C(=O)NCCN)c2c1C
Show InChI InChI=1S/C20H22FN5O4S/c1-10-15-17(24-9-25-19(15)31-16(10)20(28)29-3)26-13-5-4-12(21)8-14(13)30-11(2)18(27)23-7-6-22/h4-5,8-9,11H,6-7,22H2,1-3H3,(H,23,27)(H,24,25,26)
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n/an/a 119n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136268
PNG
(US8853193, 59)
Show SMILES CC(Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)NCCO)c(C)c12)C(=O)NCCN
Show InChI InChI=1S/C21H25FN6O4S/c1-11-16-18(26-10-27-21(16)33-17(11)20(31)25-7-8-29)28-14-4-3-13(22)9-15(14)32-12(2)19(30)24-6-5-23/h3-4,9-10,12,29H,5-8,23H2,1-2H3,(H,24,30)(H,25,31)(H,26,27,28)
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n/an/a 29n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136269
PNG
(US8853193, 60)
Show SMILES CC(Oc1cc(F)ccc1Nc1ncnc2sc(C(N)=O)c(C)c12)C(C)(C)O
Show InChI InChI=1S/C19H21FN4O3S/c1-9-14-17(22-8-23-18(14)28-15(9)16(21)25)24-12-6-5-11(20)7-13(12)27-10(2)19(3,4)26/h5-8,10,26H,1-4H3,(H2,21,25)(H,22,23,24)
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US Patent
n/an/a 37n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136217
PNG
(US8853193, 31-3 | US8853193, 61)
Show SMILES CCNC(=O)C(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)OC)c(C)c12
Show InChI InChI=1S/C20H21FN4O4S/c1-5-22-18(26)11(3)29-14-8-12(21)6-7-13(14)25-17-15-10(2)16(20(27)28-4)30-19(15)24-9-23-17/h6-9,11H,5H2,1-4H3,(H,22,26)(H,23,24,25)
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US Patent
n/an/a 77n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136222
PNG
(US8853193, 32-1 | US8853193, 62)
Show SMILES COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C(=O)NCCN(C)C)c2c1C
Show InChI InChI=1S/C22H26FN5O4S/c1-12-17-19(25-11-26-21(17)33-18(12)22(30)31-5)27-15-7-6-14(23)10-16(15)32-13(2)20(29)24-8-9-28(3)4/h6-7,10-11,13H,8-9H2,1-5H3,(H,24,29)(H,25,26,27)
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n/an/a 267n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136272
PNG
(US8853193, 63)
Show SMILES CC(Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)NCCCN(C)C)c(C)c12)C#N
Show InChI InChI=1S/C22H25FN6O2S/c1-13(11-24)31-17-10-15(23)6-7-16(17)28-20-18-14(2)19(32-22(18)27-12-26-20)21(30)25-8-5-9-29(3)4/h6-7,10,12-13H,5,8-9H2,1-4H3,(H,25,30)(H,26,27,28)
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n/an/a 17n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136240
PNG
(US8853193, 36-12)
Show SMILES CC(C)Oc1ncccc1Nc1ncnc2sc(C(=O)NCCO)c(C)c12
Show InChI InChI=1S/C18H21N5O3S/c1-10(2)26-17-12(5-4-6-20-17)23-15-13-11(3)14(16(25)19-7-8-24)27-18(13)22-9-21-15/h4-6,9-10,24H,7-8H2,1-3H3,(H,19,25)(H,21,22,23)
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n/an/a 31n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136246
PNG
(US8853193, 36-18)
Show SMILES CC(C)Oc1ncccc1Nc1ncnc2sc(C(=O)NCC#N)c(C)c12
Show InChI InChI=1S/C18H18N6O2S/c1-10(2)26-17-12(5-4-7-21-17)24-15-13-11(3)14(16(25)20-8-6-19)27-18(13)23-9-22-15/h4-5,7,9-10H,8H2,1-3H3,(H,20,25)(H,22,23,24)
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n/an/a 26n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136221
PNG
(US8853193, 31-7 | US8853193, 40)
Show SMILES CCNC(=O)C(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)NCCCN(C)C)c(C)c12
Show InChI InChI=1S/C24H31FN6O3S/c1-6-26-22(32)15(3)34-18-12-16(25)8-9-17(18)30-21-19-14(2)20(35-24(19)29-13-28-21)23(33)27-10-7-11-31(4)5/h8-9,12-13,15H,6-7,10-11H2,1-5H3,(H,26,32)(H,27,33)(H,28,29,30)
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n/an/a 20n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136254
PNG
(US8853193, 45)
Show SMILES CC(CCNS(C)(=O)=O)Oc1ncccc1Nc1ncnc2sc(C(N)=O)c(C)c12
Show InChI InChI=1S/C18H22N6O4S2/c1-10(6-8-23-30(3,26)27)28-17-12(5-4-7-20-17)24-16-13-11(2)14(15(19)25)29-18(13)22-9-21-16/h4-5,7,9-10,23H,6,8H2,1-3H3,(H2,19,25)(H,21,22,24)
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n/an/a 20n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136192
PNG
(US8853193, 23-1)
Show SMILES COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c2c1C
Show InChI InChI=1S/C18H16F3N3O3S/c1-9-14-16(22-8-23-17(14)28-15(9)18(25)26-2)24-12-4-3-10(21)5-13(12)27-11(6-19)7-20/h3-5,8,11H,6-7H2,1-2H3,(H,22,23,24)
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n/an/a 78n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136230
PNG
(US8853193, 36-2)
Show SMILES CC(C)Oc1ncccc1Nc1ncnc2sc(C(=O)NCCCCO)c(C)c12
Show InChI InChI=1S/C20H25N5O3S/c1-12(2)28-19-14(7-6-9-22-19)25-17-15-13(3)16(29-20(15)24-11-23-17)18(27)21-8-4-5-10-26/h6-7,9,11-12,26H,4-5,8,10H2,1-3H3,(H,21,27)(H,23,24,25)
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n/an/a 42n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
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