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Compile Data Set for Download or QSAR

Found 497 hits Enz. Inhib. hit(s) with Target = 'MDM2 and p53'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215050
PNG
(US9296736, 1)
Show SMILES CC[C@H](N1[C@@H](C(C[C@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C27H31Cl2NO5/c1-5-22(26(34)35-27(2,3)4)30-24(16-9-11-19(28)12-10-16)21(17-7-6-8-20(29)13-17)14-18(25(30)33)15-23(31)32/h6-13,18,21-22,24H,5,14-15H2,1-4H3,(H,31,32)/t18-,21?,22+,24-/m1/s1
PDB
MMDB

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UniChem
US Patent
n/an/a 40n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215051
PNG
(US9296736, 2 | US9593129, Example 2)
Show SMILES CC[C@H](N1[C@@H]([C@H](C[C@@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C27H31Cl2NO5/c1-5-22(26(34)35-27(2,3)4)30-24(16-9-11-19(28)12-10-16)21(17-7-6-8-20(29)13-17)14-18(25(30)33)15-23(31)32/h6-13,18,21-22,24H,5,14-15H2,1-4H3,(H,31,32)/t18-,21+,22-,24+/m0/s1
PDB
MMDB

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PC sid
UniChem
US Patent
n/an/a 200n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215052
PNG
(US9296736, 3)
Show SMILES CCOC(=O)[C@H](CC)N1C([C@H](C[C@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H27Cl2NO5/c1-3-21(25(32)33-4-2)28-23(15-8-10-18(26)11-9-15)20(16-6-5-7-19(27)12-16)13-17(24(28)31)14-22(29)30/h5-12,17,20-21,23H,3-4,13-14H2,1-2H3,(H,29,30)/t17-,20-,21+,23?/m1/s1
PDB
MMDB

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US Patent
n/an/a 60n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215053
PNG
(US9296736, 4)
Show SMILES CCOC(=O)[C@H](CC(C)C)N1C([C@H](C[C@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H31Cl2NO5/c1-4-35-27(34)23(12-16(2)3)30-25(17-8-10-20(28)11-9-17)22(18-6-5-7-21(29)13-18)14-19(26(30)33)15-24(31)32/h5-11,13,16,19,22-23,25H,4,12,14-15H2,1-3H3,(H,31,32)/t19-,22-,23+,25?/m1/s1
PDB
MMDB

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n/an/a 190n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215054
PNG
(US9296736, 5)
Show SMILES CCC[C@H](N1C([C@H](C[C@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1)C(=O)OCC
Show InChI InChI=1S/C26H29Cl2NO5/c1-3-6-22(26(33)34-4-2)29-24(16-9-11-19(27)12-10-16)21(17-7-5-8-20(28)13-17)14-18(25(29)32)15-23(30)31/h5,7-13,18,21-22,24H,3-4,6,14-15H2,1-2H3,(H,30,31)/t18-,21-,22+,24?/m1/s1
PDB
MMDB

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US Patent
n/an/a 270n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215055
PNG
(US9296736, 6 | US9593129, Example 6)
Show SMILES CCOC(=O)[C@H](C1CC1)N1[C@@H]([C@H](C[C@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H27Cl2NO5/c1-2-34-26(33)24(16-6-7-16)29-23(15-8-10-19(27)11-9-15)21(17-4-3-5-20(28)12-17)13-18(25(29)32)14-22(30)31/h3-5,8-12,16,18,21,23-24H,2,6-7,13-14H2,1H3,(H,30,31)/t18-,21-,23-,24+/m1/s1
PDB
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US Patent
n/an/a 40n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215056
PNG
(US9296736, 7)
Show SMILES CC[C@@H](CO)N1C([C@H](C[C@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25Cl2NO4/c1-2-19(13-27)26-22(14-6-8-17(24)9-7-14)20(15-4-3-5-18(25)10-15)11-16(23(26)30)12-21(28)29/h3-10,16,19-20,22,27H,2,11-13H2,1H3,(H,28,29)/t16-,19+,20-,22?/m1/s1
PDB
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US Patent
n/an/a 50n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215057
PNG
(US9296736, 8 | US9593129, Example 8)
Show SMILES OC[C@H](C1CC1)N1[C@@H]([C@H](C[C@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H25Cl2NO4/c25-18-8-6-15(7-9-18)23-20(16-2-1-3-19(26)10-16)11-17(12-22(29)30)24(31)27(23)21(13-28)14-4-5-14/h1-3,6-10,14,17,20-21,23,28H,4-5,11-13H2,(H,29,30)/t17-,20-,21-,23-/m1/s1
PDB
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n/an/a 40n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215058
PNG
(US9296736, 9)
Show SMILES CC[C@@H](COCC1CC1)N1C([C@H](C[C@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H31Cl2NO4/c1-2-23(16-34-15-17-6-7-17)30-26(18-8-10-21(28)11-9-18)24(19-4-3-5-22(29)12-19)13-20(27(30)33)14-25(31)32/h3-5,8-12,17,20,23-24,26H,2,6-7,13-16H2,1H3,(H,31,32)/t20-,23+,24-,26?/m1/s1
PDB
MMDB

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US Patent
n/an/a 30n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215059
PNG
(US9296736, 10)
Show SMILES CC[C@@H](COC)N1C([C@H](C[C@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H27Cl2NO4/c1-3-20(14-31-2)27-23(15-7-9-18(25)10-8-15)21(16-5-4-6-19(26)11-16)12-17(24(27)30)13-22(28)29/h4-11,17,20-21,23H,3,12-14H2,1-2H3,(H,28,29)/t17-,20+,21-,23?/m1/s1
PDB
MMDB

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US Patent
n/an/a 70n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215060
PNG
(US9296736, 11)
Show SMILES CC[C@@H](COCCOC)N1C([C@H](C[C@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H31Cl2NO5/c1-3-22(16-34-12-11-33-2)29-25(17-7-9-20(27)10-8-17)23(18-5-4-6-21(28)13-18)14-19(26(29)32)15-24(30)31/h4-10,13,19,22-23,25H,3,11-12,14-16H2,1-2H3,(H,30,31)/t19-,22+,23-,25?/m1/s1
PDB
MMDB

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US Patent
n/an/a 90n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215061
PNG
(US9296736, 12)
Show SMILES CC[C@@H](COCC1(CC1)C#N)N1C([C@H](C[C@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C28H30Cl2N2O4/c1-2-23(15-36-17-28(16-31)10-11-28)32-26(18-6-8-21(29)9-7-18)24(19-4-3-5-22(30)12-19)13-20(27(32)35)14-25(33)34/h3-9,12,20,23-24,26H,2,10-11,13-15,17H2,1H3,(H,33,34)/t20-,23+,24-,26?/m1/s1
PDB
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US Patent
n/an/a 40n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215062
PNG
(US9296736, 13 | US9593129, Example 13)
Show SMILES CC[C@@H](COCC1CC1)N1[C@@H]([C@H](C[C@@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H31Cl2NO4/c1-2-23(16-34-15-17-6-7-17)30-26(18-8-10-21(28)11-9-18)24(19-4-3-5-22(29)12-19)13-20(27(30)33)14-25(31)32/h3-5,8-12,17,20,23-24,26H,2,6-7,13-16H2,1H3,(H,31,32)/t20-,23-,24+,26+/m0/s1
PDB
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US Patent
n/an/a 110n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215063
PNG
(US9296736, 14 | US9593129, Example 14)
Show SMILES CC[C@@H](COC)N1[C@@H]([C@H](C[C@@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H27Cl2NO4/c1-3-20(14-31-2)27-23(15-7-9-18(25)10-8-15)21(16-5-4-6-19(26)11-16)12-17(24(27)30)13-22(28)29/h4-11,17,20-21,23H,3,12-14H2,1-2H3,(H,28,29)/t17-,20-,21+,23+/m0/s1
PDB
MMDB

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US Patent
n/an/a 290n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215064
PNG
(US9296736, 15 | US9593129, Example 15)
Show SMILES CC[C@@H](COCCOC)N1[C@@H]([C@H](C[C@@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H31Cl2NO5/c1-3-22(16-34-12-11-33-2)29-25(17-7-9-20(27)10-8-17)23(18-5-4-6-21(28)13-18)14-19(26(29)32)15-24(30)31/h4-10,13,19,22-23,25H,3,11-12,14-16H2,1-2H3,(H,30,31)/t19-,22-,23+,25+/m0/s1
PDB
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n/an/a 240n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215065
PNG
(US9296736, 16)
Show SMILES CC[C@@H](COCC1(CC1)C(N)=O)N1C([C@H](C[C@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C28H32Cl2N2O5/c1-2-22(15-37-16-28(10-11-28)27(31)36)32-25(17-6-8-20(29)9-7-17)23(18-4-3-5-21(30)12-18)13-19(26(32)35)14-24(33)34/h3-9,12,19,22-23,25H,2,10-11,13-16H2,1H3,(H2,31,36)(H,33,34)/t19-,22+,23-,25?/m1/s1
PDB
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n/an/a 70n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215066
PNG
(US9296736, 17)
Show SMILES CC[C@@H](COCC1(CC1)C(N)=O)N1C([C@H](C[C@@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C28H32Cl2N2O5/c1-2-22(15-37-16-28(10-11-28)27(31)36)32-25(17-6-8-20(29)9-7-17)23(18-4-3-5-21(30)12-18)13-19(26(32)35)14-24(33)34/h3-9,12,19,22-23,25H,2,10-11,13-16H2,1H3,(H2,31,36)(H,33,34)/t19-,22-,23+,25?/m0/s1
PDB
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n/an/a 240n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215067
PNG
(US9296736, 18)
Show SMILES CC[C@@H](COCC(C)(C)O)N1C([C@H](C[C@@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H33Cl2NO5/c1-4-22(15-35-16-27(2,3)34)30-25(17-8-10-20(28)11-9-17)23(18-6-5-7-21(29)12-18)13-19(26(30)33)14-24(31)32/h5-12,19,22-23,25,34H,4,13-16H2,1-3H3,(H,31,32)/t19-,22-,23+,25?/m0/s1
PDB
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n/an/a 110n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215068
PNG
(US9296736, 19 | US9296736, 20 | US9593129, Example...)
Show SMILES CC[C@@H](C(O)C(F)(F)F)N1[C@@H]([C@H](C[C@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H24Cl2F3NO4/c1-2-19(22(33)24(27,28)29)30-21(13-6-8-16(25)9-7-13)18(14-4-3-5-17(26)10-14)11-15(23(30)34)12-20(31)32/h3-10,15,18-19,21-22,33H,2,11-12H2,1H3,(H,31,32)/t15-,18-,19+,21-,22?/m1/s1
PDB
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n/an/a 10n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215068
PNG
(US9296736, 19 | US9296736, 20 | US9593129, Example...)
Show SMILES CC[C@@H](C(O)C(F)(F)F)N1[C@@H]([C@H](C[C@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H24Cl2F3NO4/c1-2-19(22(33)24(27,28)29)30-21(13-6-8-16(25)9-7-13)18(14-4-3-5-17(26)10-14)11-15(23(30)34)12-20(31)32/h3-10,15,18-19,21-22,33H,2,11-12H2,1H3,(H,31,32)/t15-,18-,19+,21-,22?/m1/s1
PDB
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n/an/a 70n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215070
PNG
(US9296736, 21 | US9593129, Example 21)
Show SMILES CC[C@@H](CN1CCOCC1)N1[C@@H]([C@H](C[C@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H32Cl2N2O4/c1-2-23(17-30-10-12-35-13-11-30)31-26(18-6-8-21(28)9-7-18)24(19-4-3-5-22(29)14-19)15-20(27(31)34)16-25(32)33/h3-9,14,20,23-24,26H,2,10-13,15-17H2,1H3,(H,32,33)/t20-,23+,24-,26-/m1/s1
PDB
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n/an/a 70n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215071
PNG
(US9296736, 22)
Show SMILES CCNC[C@@H](CC)N1[C@@H]([C@H](C[C@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H30Cl2N2O3/c1-3-21(15-28-4-2)29-24(16-8-10-19(26)11-9-16)22(17-6-5-7-20(27)12-17)13-18(25(29)32)14-23(30)31/h5-12,18,21-22,24,28H,3-4,13-15H2,1-2H3,(H,30,31)/t18-,21-,22-,24-/m1/s1
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n/an/a 490n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215072
PNG
(US9296736, 23 | US9593129, Example 23)
Show SMILES CC[C@@H](CNCC(F)(F)F)N1[C@@H]([C@H](C[C@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H27Cl2F3N2O3/c1-2-20(13-31-14-25(28,29)30)32-23(15-6-8-18(26)9-7-15)21(16-4-3-5-19(27)10-16)11-17(24(32)35)12-22(33)34/h3-10,17,20-21,23,31H,2,11-14H2,1H3,(H,33,34)/t17-,20+,21-,23-/m1/s1
PDB
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n/an/a 170n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215073
PNG
(US9296736, 24 | US9593129, Example 24)
Show SMILES CC[C@@H](CN1CCCC1)N1[C@@H]([C@H](C[C@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H32Cl2N2O3/c1-2-23(17-30-12-3-4-13-30)31-26(18-8-10-21(28)11-9-18)24(19-6-5-7-22(29)14-19)15-20(27(31)34)16-25(32)33/h5-11,14,20,23-24,26H,2-4,12-13,15-17H2,1H3,(H,32,33)/t20-,23+,24-,26-/m1/s1
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n/an/a 570n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215074
PNG
(US9296736, 25)
Show SMILES CC[C@H](CN1CCCC1=O)N1[C@@H]([C@H](C[C@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H30Cl2N2O4/c1-2-22(16-30-12-4-7-24(30)32)31-26(17-8-10-20(28)11-9-17)23(18-5-3-6-21(29)13-18)14-19(27(31)35)15-25(33)34/h3,5-6,8-11,13,19,22-23,26H,2,4,7,12,14-16H2,1H3,(H,33,34)/t19-,22-,23-,26-/m1/s1
PDB
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n/an/a 140n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215075
PNG
(US9296736, 26 | US9593129, Example 26)
Show SMILES CC[C@@H](CN1CCS(=O)(=O)CC1)N1[C@@H]([C@H](C[C@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H32Cl2N2O5S/c1-2-23(17-30-10-12-37(35,36)13-11-30)31-26(18-6-8-21(28)9-7-18)24(19-4-3-5-22(29)14-19)15-20(27(31)34)16-25(32)33/h3-9,14,20,23-24,26H,2,10-13,15-17H2,1H3,(H,32,33)/t20-,23+,24-,26-/m1/s1
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n/an/a 130n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215076
PNG
(US9296736, 27 | US9296736, 36 | US9593129, Example...)
Show SMILES CC[C@@H](CNc1nccs1)N1[C@@H]([C@H](C[C@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H27Cl2N3O3S/c1-2-21(15-30-26-29-10-11-35-26)31-24(16-6-8-19(27)9-7-16)22(17-4-3-5-20(28)12-17)13-18(25(31)34)14-23(32)33/h3-12,18,21-22,24H,2,13-15H2,1H3,(H,29,30)(H,32,33)/t18-,21+,22-,24-/m1/s1
PDB
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n/an/a 100n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215077
PNG
(US9296736, 28 | US9593129, Example 28)
Show SMILES CC[C@@H](CNC(C)=O)N1[C@@H]([C@H](C[C@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H28Cl2N2O4/c1-3-21(14-28-15(2)30)29-24(16-7-9-19(26)10-8-16)22(17-5-4-6-20(27)11-17)12-18(25(29)33)13-23(31)32/h4-11,18,21-22,24H,3,12-14H2,1-2H3,(H,28,30)(H,31,32)/t18-,21+,22-,24-/m1/s1
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n/an/a 180n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215078
PNG
(US9296736, 29 | US9593129, Example 29)
Show SMILES CC[C@@H](CNS(C)(=O)=O)N1[C@@H]([C@H](C[C@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H28Cl2N2O5S/c1-3-20(14-27-34(2,32)33)28-23(15-7-9-18(25)10-8-15)21(16-5-4-6-19(26)11-16)12-17(24(28)31)13-22(29)30/h4-11,17,20-21,23,27H,3,12-14H2,1-2H3,(H,29,30)/t17-,20+,21-,23-/m1/s1
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n/an/a 30n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215079
PNG
(US9296736, 30 | US9593129, Example 30)
Show SMILES CC[C@@H](CCC#N)N1[C@@H]([C@H](C[C@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H26Cl2N2O3/c1-2-21(7-4-12-28)29-24(16-8-10-19(26)11-9-16)22(17-5-3-6-20(27)13-17)14-18(25(29)32)15-23(30)31/h3,5-6,8-11,13,18,21-22,24H,2,4,7,14-15H2,1H3,(H,30,31)/t18-,21+,22-,24-/m1/s1
PDB
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n/an/a 30n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215080
PNG
(US9296736, 31 | US9593129, Example 31)
Show SMILES CC[C@@H](CCS(C)(=O)=O)N1[C@@H]([C@H](C[C@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H29Cl2NO5S/c1-3-21(11-12-34(2,32)33)28-24(16-7-9-19(26)10-8-16)22(17-5-4-6-20(27)13-17)14-18(25(28)31)15-23(29)30/h4-10,13,18,21-22,24H,3,11-12,14-15H2,1-2H3,(H,29,30)/t18-,21+,22-,24-/m1/s1
PDB
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n/an/a 50n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215081
PNG
(US9296736, 32 | US9593129, Example 32)
Show SMILES CC[C@@H](CCc1ccccn1)N1[C@@H]([C@H](C[C@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C29H30Cl2N2O3/c1-2-25(14-13-24-8-3-4-15-32-24)33-28(19-9-11-22(30)12-10-19)26(20-6-5-7-23(31)16-20)17-21(29(33)36)18-27(34)35/h3-12,15-16,21,25-26,28H,2,13-14,17-18H2,1H3,(H,34,35)/t21-,25+,26-,28-/m1/s1
PDB
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n/an/a 90n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215082
PNG
(US9296736, 33 | US9593129, Example 33)
Show SMILES CCNC(=O)[C@H](CC)N1[C@@H]([C@H](C[C@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H28Cl2N2O4/c1-3-21(24(32)28-4-2)29-23(15-8-10-18(26)11-9-15)20(16-6-5-7-19(27)12-16)13-17(25(29)33)14-22(30)31/h5-12,17,20-21,23H,3-4,13-14H2,1-2H3,(H,28,32)(H,30,31)/t17-,20-,21+,23-/m1/s1
PDB
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n/an/a 410n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215083
PNG
(US9296736, 34)
Show SMILES CC[C@H](N1[C@@H](C(C[C@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1)c1nnc(C)o1
Show InChI InChI=1S/C25H25Cl2N3O4/c1-3-21(24-29-28-14(2)34-24)30-23(15-7-9-18(26)10-8-15)20(16-5-4-6-19(27)11-16)12-17(25(30)33)13-22(31)32/h4-11,17,20-21,23H,3,12-13H2,1-2H3,(H,31,32)/t17-,20?,21+,23-/m1/s1
PDB
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n/an/a 710n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215084
PNG
(US9296736, 35)
Show SMILES OC(=O)C[C@H]1CC([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H23Cl2NO3/c24-18-8-6-15(7-9-18)22-20(16-2-1-3-19(25)10-16)11-17(12-21(27)28)23(29)26(22)13-14-4-5-14/h1-3,6-10,14,17,20,22H,4-5,11-13H2,(H,27,28)/t17-,20?,22-/m1/s1
PDB
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n/an/a 150n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215076
PNG
(US9296736, 27 | US9296736, 36 | US9593129, Example...)
Show SMILES CC[C@@H](CNc1nccs1)N1[C@@H]([C@H](C[C@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H27Cl2N3O3S/c1-2-21(15-30-26-29-10-11-35-26)31-24(16-6-8-19(27)9-7-16)22(17-4-3-5-20(28)12-17)13-18(25(31)34)14-23(32)33/h3-12,18,21-22,24H,2,13-15H2,1H3,(H,29,30)(H,32,33)/t18-,21+,22-,24-/m1/s1
PDB
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n/an/a 4.30E+3n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215086
PNG
(US9296736, 37 | US9593129, Example 37)
Show SMILES CCC(CC)CN1[C@@H]([C@H](C[C@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H29Cl2NO3/c1-3-16(4-2)15-28-24(17-8-10-20(26)11-9-17)22(18-6-5-7-21(27)12-18)13-19(25(28)31)14-23(29)30/h5-12,16,19,22,24H,3-4,13-15H2,1-2H3,(H,29,30)/t19-,22-,24-/m1/s1
PDB
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n/an/a 60n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215087
PNG
(US9296736, 38 | US9593129, Example 38)
Show SMILES OC(=O)C[C@H]1C[C@@H]([C@H](N(CC2CCCC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C25H27Cl2NO3/c26-20-10-8-17(9-11-20)24-22(18-6-3-7-21(27)12-18)13-19(14-23(29)30)25(31)28(24)15-16-4-1-2-5-16/h3,6-12,16,19,22,24H,1-2,4-5,13-15H2,(H,29,30)/t19-,22-,24-/m1/s1
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n/an/a 190n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215088
PNG
(US9296736, 39 | US9593129, Example 39)
Show SMILES CC1(C)CCCC1CN1[C@@H]([C@H](C[C@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H31Cl2NO3/c1-27(2)12-4-6-20(27)16-30-25(17-8-10-21(28)11-9-17)23(18-5-3-7-22(29)13-18)14-19(26(30)33)15-24(31)32/h3,5,7-11,13,19-20,23,25H,4,6,12,14-16H2,1-2H3,(H,31,32)/t19-,20?,23-,25-/m1/s1
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n/an/a 300n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215089
PNG
(US9296736, 40 | US9593129, Example 40)
Show SMILES OC(=O)C[C@H]1C[C@@H]([C@H](N(CC2CCCCC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C26H29Cl2NO3/c27-21-11-9-18(10-12-21)25-23(19-7-4-8-22(28)13-19)14-20(15-24(30)31)26(32)29(25)16-17-5-2-1-3-6-17/h4,7-13,17,20,23,25H,1-3,5-6,14-16H2,(H,30,31)/t20-,23-,25-/m1/s1
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n/an/a 170n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215090
PNG
(US9296736, 41)
Show SMILES OC(=O)C[C@@H]1CC([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H23Cl2NO3/c24-18-8-6-15(7-9-18)22-20(16-2-1-3-19(25)10-16)11-17(12-21(27)28)23(29)26(22)13-14-4-5-14/h1-3,6-10,14,17,20,22H,4-5,11-13H2,(H,27,28)/t17-,20?,22+/m0/s1
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n/an/a 320n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215091
PNG
(US9296736, 42)
Show SMILES CCCN1[C@@H](C(C[C@@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H23Cl2NO3/c1-2-10-25-21(14-6-8-17(23)9-7-14)19(15-4-3-5-18(24)11-15)12-16(22(25)28)13-20(26)27/h3-9,11,16,19,21H,2,10,12-13H2,1H3,(H,26,27)/t16-,19?,21+/m0/s1
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n/an/a 410n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215092
PNG
(US9296736, 43 | US9593129, Example 43)
Show SMILES OC(=O)C[C@@H]1CC([C@H](N(CC2CCC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C24H25Cl2NO3/c25-19-9-7-16(8-10-19)23-21(17-5-2-6-20(26)11-17)12-18(13-22(28)29)24(30)27(23)14-15-3-1-4-15/h2,5-11,15,18,21,23H,1,3-4,12-14H2,(H,28,29)/t18-,21?,23+/m0/s1
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n/an/a 1.97E+3n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215093
PNG
(US9296736, 44 | US9593129, Example 44)
Show SMILES CC(C)CN1[C@@H](C(C[C@@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25Cl2NO3/c1-14(2)13-26-22(15-6-8-18(24)9-7-15)20(16-4-3-5-19(25)10-16)11-17(23(26)29)12-21(27)28/h3-10,14,17,20,22H,11-13H2,1-2H3,(H,27,28)/t17-,20?,22+/m0/s1
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n/an/a 450n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215094
PNG
(US9296736, 45 | US9593129, Example 45)
Show SMILES OC(=O)C[C@@H]1CC([C@H](N(CC2CCCC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C25H27Cl2NO3/c26-20-10-8-17(9-11-20)24-22(18-6-3-7-21(27)12-18)13-19(14-23(29)30)25(31)28(24)15-16-4-1-2-5-16/h3,6-12,16,19,22,24H,1-2,4-5,13-15H2,(H,29,30)/t19-,22?,24+/m0/s1
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n/an/a 550n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215095
PNG
(US9296736, 46 | US9593129, Example 46)
Show SMILES CCC(CC)N1[C@@H]([C@H](C[C@@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H27Cl2NO3/c1-3-20(4-2)27-23(15-8-10-18(25)11-9-15)21(16-6-5-7-19(26)12-16)13-17(24(27)30)14-22(28)29/h5-12,17,20-21,23H,3-4,13-14H2,1-2H3,(H,28,29)/t17-,21+,23+/m0/s1
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n/an/a 270n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215096
PNG
(US9296736, 47)
Show SMILES COC(=O)C[C@H]1C[C@@H]([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C24H25Cl2NO3/c1-30-22(28)13-18-12-21(17-3-2-4-20(26)11-17)23(16-7-9-19(25)10-8-16)27(24(18)29)14-15-5-6-15/h2-4,7-11,15,18,21,23H,5-6,12-14H2,1H3/t18-,21-,23-/m1/s1
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n/an/a 3.63E+3n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215097
PNG
(US9296736, 48)
Show SMILES NC(=O)C[C@H]1C[C@@H]([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H24Cl2N2O2/c24-18-8-6-15(7-9-18)22-20(16-2-1-3-19(25)10-16)11-17(12-21(26)28)23(29)27(22)13-14-4-5-14/h1-3,6-10,14,17,20,22H,4-5,11-13H2,(H2,26,28)/t17-,20-,22-/m1/s1
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n/an/a 1.37E+3n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215098
PNG
(US9296736, 49 | US9593129, Example 49)
Show SMILES CCOC(=O)CNC(=O)C[C@H]1C[C@@H]([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C27H30Cl2N2O4/c1-2-35-25(33)15-30-24(32)14-20-13-23(19-4-3-5-22(29)12-19)26(18-8-10-21(28)11-9-18)31(27(20)34)16-17-6-7-17/h3-5,8-12,17,20,23,26H,2,6-7,13-16H2,1H3,(H,30,32)/t20-,23-,26-/m1/s1
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n/an/a 2.38E+3n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
MDM2 and p53


(Homo sapiens (human)-Homo sapiens (Human))
BDBM215099
PNG
(US9296736, 50)
Show SMILES OC(=O)CNC(=O)C[C@H]1C[C@@H]([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C25H26Cl2N2O4/c26-19-8-6-16(7-9-19)24-21(17-2-1-3-20(27)10-17)11-18(12-22(30)28-13-23(31)32)25(33)29(24)14-15-4-5-15/h1-3,6-10,15,18,21,24H,4-5,11-14H2,(H,28,30)(H,31,32)/t18-,21-,24-/m1/s1
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n/an/a 830n/an/an/an/a7.425



Amgen INC.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...


US Patent US9296736 (2016)


BindingDB Entry DOI: 10.7270/Q29022M2
More data for this
Ligand-Target Pair
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