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Found 1411 hits Enz. Inhib. hit(s) with Target = 'Macrophage colony stimulating factor receptor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM276741
PNG
(US10071991, Compound (I-M2) | US9611259, Compound ...)
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1CC(C)(C)OC(C)(C1)C(O)=O
Show InChI InChI=1S/C27H33N5O4/c1-25(2)10-8-16(9-11-25)21-20(32-23(33)22-29-15-18(14-28)30-22)7-6-19(31-21)17-12-26(3,4)36-27(5,13-17)24(34)35/h6-8,15,17H,9-13H2,1-5H3,(H,29,30)(H,32,33)(H,34,35)
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n/an/a 11n/an/an/an/a7.025



Janssen Pharmaceutica NV

US Patent


Assay Description
c-fms(h) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKSPGEYVNIEFG, 10 mM MgAcetate and [γ-33P-ATP] (specific activity approx...


US Patent US10071991 (2018)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM276742
PNG
(US10071991, Compound (I-M7) | US9611259, Compound ...)
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1CC(C)(C)OC(C)(CO)C1
Show InChI InChI=1S/C27H35N5O3/c1-25(2)10-8-17(9-11-25)22-21(32-24(34)23-29-15-19(14-28)30-23)7-6-20(31-22)18-12-26(3,4)35-27(5,13-18)16-33/h6-8,15,18,33H,9-13,16H2,1-5H3,(H,29,30)(H,32,34)
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n/an/a 10n/an/an/an/a7.025



Janssen Pharmaceutica NV

US Patent


Assay Description
c-fms(h) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKSPGEYVNIEFG, 10 mM MgAcetate and [γ-33P-ATP] (specific activity approx...


US Patent US10071991 (2018)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM276743
PNG
(US10071991, Compound (P) | US9611259, Compound (P))
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1CC(C)(C)OC(C)(C)C1
Show InChI InChI=1S/C27H35N5O2/c1-25(2)11-9-17(10-12-25)22-21(32-24(33)23-29-16-19(15-28)30-23)8-7-20(31-22)18-13-26(3,4)34-27(5,6)14-18/h7-9,16,18H,10-14H2,1-6H3,(H,29,30)(H,32,33)
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n/an/a 18n/an/an/an/a7.025



Janssen Pharmaceutica NV

US Patent


Assay Description
c-fms(h) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKSPGEYVNIEFG, 10 mM MgAcetate and [γ-33P-ATP] (specific activity approx...


US Patent US10071991 (2018)

More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM276743
PNG
(US10071991, Compound (P) | US9611259, Compound (P))
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1CC(C)(C)OC(C)(C)C1
Show InChI InChI=1S/C27H35N5O2/c1-25(2)11-9-17(10-12-25)22-21(32-24(33)23-29-16-19(15-28)30-23)8-7-20(31-22)18-13-26(3,4)34-27(5,6)14-18/h7-9,16,18H,10-14H2,1-6H3,(H,29,30)(H,32,33)
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n/an/a 10n/an/an/an/a7.025



Janssen Pharmaceutica NV

US Patent


Assay Description
In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...


US Patent US10071991 (2018)

More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM276745
PNG
(US10071991, Compound (I-M2-2R,4S))
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)[C@H]1CC(C)(C)O[C@](C)(C1)C(O)=O
Show InChI InChI=1S/C27H33N5O4/c1-25(2)10-8-16(9-11-25)21-20(32-23(33)22-29-15-18(14-28)30-22)7-6-19(31-21)17-12-26(3,4)36-27(5,13-17)24(34)35/h6-8,15,17H,9-13H2,1-5H3,(H,29,30)(H,32,33)(H,34,35)/t17-,27+/m0/s1
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n/an/a 1.80n/an/an/an/a7.025



Janssen Pharmaceutica NV

US Patent


Assay Description
In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...


US Patent US10071991 (2018)

More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM276746
PNG
(US10071991, Compound (I-M7-2S,4R))
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)[C@@H]1CC(C)(C)O[C@](C)(CO)C1
Show InChI InChI=1S/C27H35N5O3/c1-25(2)10-8-17(9-11-25)22-21(32-24(34)23-29-15-19(14-28)30-23)7-6-20(31-22)18-12-26(3,4)35-27(5,13-18)16-33/h6-8,15,18,33H,9-13,16H2,1-5H3,(H,29,30)(H,32,34)/t18-,27+/m1/s1
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n/an/a 7.90n/an/an/an/a7.025



Janssen Pharmaceutica NV

US Patent


Assay Description
In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...


US Patent US10071991 (2018)

More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM276747
PNG
(US10071991, Compound (I-M7-2R,4S))
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)[C@H]1CC(C)(C)O[C@](C)(CO)C1
Show InChI InChI=1S/C27H35N5O3/c1-25(2)10-8-17(9-11-25)22-21(32-24(34)23-29-15-19(14-28)30-23)7-6-20(31-22)18-12-26(3,4)35-27(5,13-18)16-33/h6-8,15,18,33H,9-13,16H2,1-5H3,(H,29,30)(H,32,34)/t18-,27-/m0/s1
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n/an/a 7.10n/an/an/an/a7.025



Janssen Pharmaceutica NV

US Patent


Assay Description
In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...


US Patent US10071991 (2018)

More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM276744
PNG
(US10071991, Compound (I-M2-2S,4R))
Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)[C@@H]1CC(C)(C)O[C@@](C)(C1)C(O)=O
Show InChI InChI=1S/C27H33N5O4/c1-25(2)10-8-16(9-11-25)21-20(32-23(33)22-29-15-18(14-28)30-22)7-6-19(31-21)17-12-26(3,4)36-27(5,13-17)24(34)35/h6-8,15,17H,9-13H2,1-5H3,(H,29,30)(H,32,33)(H,34,35)/t17-,27+/m1/s1
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n/an/a 2.20n/an/an/an/a7.025



Janssen Pharmaceutica NV

US Patent


Assay Description
In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...


US Patent US10071991 (2018)

More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM50381716
PNG
(ABT-348 | ILORASERTIB | US8722890, 1 | US8722890, ...)
Show SMILES Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12
Show InChI InChI=1S/C25H21FN6O2S/c26-17-2-1-3-19(10-17)31-25(34)30-18-6-4-15(5-7-18)21-14-35-23-20(12-28-24(27)22(21)23)16-11-29-32(13-16)8-9-33/h1-7,10-14,33H,8-9H2,(H2,27,28)(H2,30,31,34)
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n/an/a 3.42n/an/an/an/a7.125



AbbVie Inc.

US Patent


Assay Description
To determine the activity of the various kinases, a homogenous time-resolved fluorescence (HTRF) in vitro kinase assay was used. (Mathis, G., HTRF(R)...


US Patent US8722890 (2014)


BindingDB Entry DOI: 10.7270/Q21Z4327
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM50381716
PNG
(ABT-348 | ILORASERTIB | US8722890, 1 | US8722890, ...)
Show SMILES Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12
Show InChI InChI=1S/C25H21FN6O2S/c26-17-2-1-3-19(10-17)31-25(34)30-18-6-4-15(5-7-18)21-14-35-23-20(12-28-24(27)22(21)23)16-11-29-32(13-16)8-9-33/h1-7,10-14,33H,8-9H2,(H2,27,28)(H2,30,31,34)
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n/an/a 2.22n/an/an/an/a7.125



AbbVie Inc.

US Patent


Assay Description
To determine the activity of the various kinases, a homogenous time-resolved fluorescence (HTRF) in vitro kinase assay was used. (Mathis, G., HTRF(R)...


US Patent US8722890 (2014)


BindingDB Entry DOI: 10.7270/Q21Z4327
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM50381698
PNG
(CHEMBL1969102 | US8722890, 6)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3c(cnc(N)c23)-c2cn[nH]c2)c1
Show InChI InChI=1S/C24H20N6OS/c1-14-3-2-4-18(9-14)30-24(31)29-17-7-5-15(6-8-17)20-13-32-22-19(16-10-27-28-11-16)12-26-23(25)21(20)22/h2-13H,1H3,(H2,25,26)(H,27,28)(H2,29,30,31)
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n/an/a 2.74n/an/an/an/a7.125



AbbVie Inc.

US Patent


Assay Description
To determine the activity of the various kinases, a homogenous time-resolved fluorescence (HTRF) in vitro kinase assay was used. (Mathis, G., HTRF(R)...


US Patent US8722890 (2014)


BindingDB Entry DOI: 10.7270/Q21Z4327
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM121389
PNG
(US8722890, 4)
Show SMILES COc1ccc(NC(=O)Nc2ccc(cc2)-c2csc3c(cnc(N)c23)-c2cnn(CC(C)(C)O)c2)cc1
Show InChI InChI=1S/C28H28N6O3S/c1-28(2,36)16-34-14-18(12-31-34)22-13-30-26(29)24-23(15-38-25(22)24)17-4-6-19(7-5-17)32-27(35)33-20-8-10-21(37-3)11-9-20/h4-15,36H,16H2,1-3H3,(H2,29,30)(H2,32,33,35)
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n/an/a 7.87n/an/an/an/a7.125



AbbVie Inc.

US Patent


Assay Description
To determine the activity of the various kinases, a homogenous time-resolved fluorescence (HTRF) in vitro kinase assay was used. (Mathis, G., HTRF(R)...


US Patent US8722890 (2014)


BindingDB Entry DOI: 10.7270/Q21Z4327
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM121390
PNG
(US8722890, 5)
Show SMILES COc1ccc(NC(=O)Nc2ccc(cc2)-c2csc3c(cnc(N)c23)-c2cnn(C[C@H](O)CO)c2)cc1
Show InChI InChI=1S/C27H26N6O4S/c1-37-21-8-6-19(7-9-21)32-27(36)31-18-4-2-16(3-5-18)23-15-38-25-22(11-29-26(28)24(23)25)17-10-30-33(12-17)13-20(35)14-34/h2-12,15,20,34-35H,13-14H2,1H3,(H2,28,29)(H2,31,32,36)/t20-/m0/s1
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n/an/a 1.34n/an/an/an/a7.125



AbbVie Inc.

US Patent


Assay Description
To determine the activity of the various kinases, a homogenous time-resolved fluorescence (HTRF) in vitro kinase assay was used. (Mathis, G., HTRF(R)...


US Patent US8722890 (2014)


BindingDB Entry DOI: 10.7270/Q21Z4327
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM121388
PNG
(US8722890, 3)
Show SMILES C[C@H](O)Cn1cc(cn1)-c1cnc(N)c2c(csc12)-c1ccc(NC(=O)Nc2cccc(C)c2)cc1
Show InChI InChI=1S/C27H26N6O2S/c1-16-4-3-5-21(10-16)32-27(35)31-20-8-6-18(7-9-20)23-15-36-25-22(12-29-26(28)24(23)25)19-11-30-33(14-19)13-17(2)34/h3-12,14-15,17,34H,13H2,1-2H3,(H2,28,29)(H2,31,32,35)/t17-/m0/s1
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n/an/a 5.62n/an/an/an/a7.125



AbbVie Inc.

US Patent


Assay Description
To determine the activity of the various kinases, a homogenous time-resolved fluorescence (HTRF) in vitro kinase assay was used. (Mathis, G., HTRF(R)...


US Patent US8722890 (2014)


BindingDB Entry DOI: 10.7270/Q21Z4327
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131993
PNG
(US8841455, 88)
Show SMILES Cc1cccc(Cn2nc(C3CC3)c3c(NC(=O)c4cnc5cc(OCCN6CCCC6)ccn45)cccc23)n1
Show InChI InChI=1S/C31H33N7O2/c1-21-6-4-7-23(33-21)20-38-26-9-5-8-25(29(26)30(35-38)22-10-11-22)34-31(39)27-19-32-28-18-24(12-15-37(27)28)40-17-16-36-13-2-3-14-36/h4-9,12,15,18-19,22H,2-3,10-11,13-14,16-17,20H2,1H3,(H,34,39)
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n/an/a 141n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131994
PNG
(US8841455, 89)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(OCCN5CC[C@H](C5)OC)ccn34)c12
Show InChI InChI=1S/C31H35N7O3/c1-4-25-30-26(9-6-10-27(30)38(35-25)19-22-8-5-7-21(2)33-22)34-31(39)28-18-32-29-17-23(12-14-37(28)29)41-16-15-36-13-11-24(20-36)40-3/h5-10,12,14,17-18,24H,4,11,13,15-16,19-20H2,1-3H3,(H,34,39)/t24-/m1/s1
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n/an/a 156n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131995
PNG
(US8841455, 90)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(OCCN5CC6CCC(C5)N6C)ccn34)c12
Show InChI InChI=1S/C33H38N8O2/c1-4-27-32-28(9-6-10-29(32)41(37-27)19-23-8-5-7-22(2)35-23)36-33(42)30-18-34-31-17-26(13-14-40(30)31)43-16-15-39-20-24-11-12-25(21-39)38(24)3/h5-10,13-14,17-18,24-25H,4,11-12,15-16,19-21H2,1-3H3,(H,36,42)
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n/an/a 164n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131996
PNG
(US8841455, 91)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(OCCN5CC[C@@H](C5)OC)ccn34)c12
Show InChI InChI=1S/C31H35N7O3/c1-4-25-30-26(9-6-10-27(30)38(35-25)19-22-8-5-7-21(2)33-22)34-31(39)28-18-32-29-17-23(12-14-37(28)29)41-16-15-36-13-11-24(20-36)40-3/h5-10,12,14,17-18,24H,4,11,13,15-16,19-20H2,1-3H3,(H,34,39)/t24-/m0/s1
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n/an/a 183n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131997
PNG
(US8841455, 92)
Show SMILES CCc1nn(Cc2ccn(CC)n2)c2cccc(NC(=O)c3cnc4cc(OCCN5CCCC5)ccn34)c12
Show InChI InChI=1S/C29H34N8O2/c1-3-23-28-24(8-7-9-25(28)37(33-23)20-21-10-14-35(4-2)32-21)31-29(38)26-19-30-27-18-22(11-15-36(26)27)39-17-16-34-12-5-6-13-34/h7-11,14-15,18-19H,3-6,12-13,16-17,20H2,1-2H3,(H,31,38)
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n/an/a 194n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131998
PNG
(US8841455, 93)
Show SMILES CN1CCC(CC1)Oc1ccn2c(cnc2c1)C(=O)Nc1cccc2n(Cc3cccc(C)n3)nc(C3CC3)c12
Show InChI InChI=1S/C31H33N7O2/c1-20-5-3-6-22(33-20)19-38-26-8-4-7-25(29(26)30(35-38)21-9-10-21)34-31(39)27-18-32-28-17-24(13-16-37(27)28)40-23-11-14-36(2)15-12-23/h3-8,13,16-18,21,23H,9-12,14-15,19H2,1-2H3,(H,34,39)
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n/an/a 198n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131999
PNG
(US8841455, 94)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(OCCN5CC[C@H](F)C5)ccn34)c12
Show InChI InChI=1S/C30H32FN7O2/c1-3-24-29-25(8-5-9-26(29)38(35-24)19-22-7-4-6-20(2)33-22)34-30(39)27-17-32-28-16-23(11-13-37(27)28)40-15-14-36-12-10-21(31)18-36/h4-9,11,13,16-17,21H,3,10,12,14-15,18-19H2,1-2H3,(H,34,39)/t21-/m0/s1
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n/an/a 219n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131906
PNG
(US8841455, 1)
Show SMILES COCCOc1ccn2c(cnc2c1)C(=O)Nc1cccc2n(Cc3ccccc3)nc(I)c12
Show InChI InChI=1S/C25H22IN5O3/c1-33-12-13-34-18-10-11-30-21(15-27-22(30)14-18)25(32)28-19-8-5-9-20-23(19)24(26)29-31(20)16-17-6-3-2-4-7-17/h2-11,14-15H,12-13,16H2,1H3,(H,28,32)
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n/an/a 112n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131907
PNG
(US8841455, 2)
Show SMILES CCc1nn(Cc2ccccc2)c2cccc(NC(=O)c3cnc4cc(OCCOC)ccn34)c12
Show InChI InChI=1S/C27H27N5O3/c1-3-21-26-22(10-7-11-23(26)32(30-21)18-19-8-5-4-6-9-19)29-27(33)24-17-28-25-16-20(12-13-31(24)25)35-15-14-34-2/h4-13,16-17H,3,14-15,18H2,1-2H3,(H,29,33)
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n/an/a 118n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131908
PNG
(US8841455, 3)
Show SMILES COCCOc1ccn2c(cnc2c1)C(=O)Nc1cccc2n(Cc3ccccc3)nc(C3CC3)c12
Show InChI InChI=1S/C28H27N5O3/c1-35-14-15-36-21-12-13-32-24(17-29-25(32)16-21)28(34)30-22-8-5-9-23-26(22)27(20-10-11-20)31-33(23)18-19-6-3-2-4-7-19/h2-9,12-13,16-17,20H,10-11,14-15,18H2,1H3,(H,30,34)
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n/an/a 57.9n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131909
PNG
(US8841455, 4)
Show SMILES CCc1nn(Cc2ccccc2)c2ccc(Cl)c(NC(=O)c3cnc4cc(OCCOC)ccn34)c12
Show InChI InChI=1S/C27H26ClN5O3/c1-3-21-25-22(33(31-21)17-18-7-5-4-6-8-18)10-9-20(28)26(25)30-27(34)23-16-29-24-15-19(11-12-32(23)24)36-14-13-35-2/h4-12,15-16H,3,13-14,17H2,1-2H3,(H,30,34)
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n/an/a 42n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131910
PNG
(US8841455, 5)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C24H22N6O/c1-3-18-23-19(27-24(31)21-14-25-22-12-4-5-13-29(21)22)10-7-11-20(23)30(28-18)15-17-9-6-8-16(2)26-17/h4-14H,3,15H2,1-2H3,(H,27,31)
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n/an/a 137n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131911
PNG
(US8841455, 6)
Show SMILES CCc1nn(Cc2ccc(C)nc2OC)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C25H24N6O2/c1-4-18-23-19(28-24(32)21-14-26-22-10-5-6-13-30(21)22)8-7-9-20(23)31(29-18)15-17-12-11-16(2)27-25(17)33-3/h5-14H,4,15H2,1-3H3,(H,28,32)
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n/an/a 516n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131912
PNG
(US8841455, 7)
Show SMILES CCc1nn(Cc2ccn(CCN3CCNCC3)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C27H31N9O/c1-2-21-26-22(30-27(37)24-18-29-25-8-3-4-12-35(24)25)6-5-7-23(26)36(32-21)19-20-9-13-34(31-20)17-16-33-14-10-28-11-15-33/h3-9,12-13,18,28H,2,10-11,14-17,19H2,1H3,(H,30,37)
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n/an/a 3.07E+3n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131913
PNG
(US8841455, 8)
Show SMILES CCc1nn(Cc2ccnn2CC(O)CO)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C24H25N7O3/c1-2-18-23-19(27-24(34)21-12-25-22-8-3-4-11-29(21)22)6-5-7-20(23)31(28-18)13-16-9-10-26-30(16)14-17(33)15-32/h3-12,17,32-33H,2,13-15H2,1H3,(H,27,34)
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n/an/a 3.00E+3n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131914
PNG
(US8841455, 9)
Show SMILES CCc1nn(Cc2cccc(OCCN)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C25H25N7O2/c1-2-18-24-19(29-25(33)21-15-27-22-10-3-4-13-31(21)22)8-6-9-20(24)32(30-18)16-17-7-5-11-23(28-17)34-14-12-26/h3-11,13,15H,2,12,14,16,26H2,1H3,(H,29,33)
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n/an/a 455n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131915
PNG
(US8841455, 10)
Show SMILES CCc1nn(Cc2cccc(OCCCN)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C26H27N7O2/c1-2-19-25-20(30-26(34)22-16-28-23-11-3-4-14-32(22)23)9-6-10-21(25)33(31-19)17-18-8-5-12-24(29-18)35-15-7-13-27/h3-6,8-12,14,16H,2,7,13,15,17,27H2,1H3,(H,30,34)
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n/an/a 395n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131916
PNG
(US8841455, 11)
Show SMILES CCc1nn(Cc2cccc(OCCCN(C)C)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C28H31N7O2/c1-4-21-27-22(31-28(36)24-18-29-25-13-5-6-16-34(24)25)11-8-12-23(27)35(32-21)19-20-10-7-14-26(30-20)37-17-9-15-33(2)3/h5-8,10-14,16,18H,4,9,15,17,19H2,1-3H3,(H,31,36)
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n/an/a 4.88E+3n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131917
PNG
(US8841455, 12)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(ccn34)C(=O)N3CCNCC3)c12
Show InChI InChI=1S/C29H30N8O2/c1-3-22-27-23(8-5-9-24(27)37(34-22)18-21-7-4-6-19(2)32-21)33-28(38)25-17-31-26-16-20(10-13-36(25)26)29(39)35-14-11-30-12-15-35/h4-10,13,16-17,30H,3,11-12,14-15,18H2,1-2H3,(H,33,38)
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n/an/a 903n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131918
PNG
(US8841455, 13)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(ccn34)C(=O)N3CCN(C)CC3)c12
Show InChI InChI=1S/C30H32N8O2/c1-4-23-28-24(9-6-10-25(28)38(34-23)19-22-8-5-7-20(2)32-22)33-29(39)26-18-31-27-17-21(11-12-37(26)27)30(40)36-15-13-35(3)14-16-36/h5-12,17-18H,4,13-16,19H2,1-3H3,(H,33,39)
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n/an/a 2.56E+3n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131919
PNG
(US8841455, 14)
Show SMILES CCc1nn(Cc2cccc(CN3CCNCC3)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C28H30N8O/c1-2-22-27-23(32-28(37)25-17-30-26-11-3-4-14-35(25)26)9-6-10-24(27)36(33-22)19-21-8-5-7-20(31-21)18-34-15-12-29-13-16-34/h3-11,14,17,29H,2,12-13,15-16,18-19H2,1H3,(H,32,37)
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n/an/a 3.84E+3n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131920
PNG
(US8841455, 15)
Show SMILES CCc1nn(Cc2cccc(OC)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C24H22N6O2/c1-3-17-23-18(27-24(31)20-14-25-21-11-4-5-13-29(20)21)9-7-10-19(23)30(28-17)15-16-8-6-12-22(26-16)32-2/h4-14H,3,15H2,1-2H3,(H,27,31)
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n/an/a 138n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131921
PNG
(US8841455, 16)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(OCCN5CCOCC5)ccn34)c12
Show InChI InChI=1S/C30H33N7O3/c1-3-24-29-25(8-5-9-26(29)37(34-24)20-22-7-4-6-21(2)32-22)33-30(38)27-19-31-28-18-23(10-11-36(27)28)40-17-14-35-12-15-39-16-13-35/h4-11,18-19H,3,12-17,20H2,1-2H3,(H,33,38)
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n/an/a 145n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131922
PNG
(US8841455, 17)
Show SMILES CCc1nn(Cc2cccc(OC3CCNC3)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C27H27N7O2/c1-2-20-26-21(31-27(35)23-16-29-24-10-3-4-14-33(23)24)8-6-9-22(26)34(32-20)17-18-7-5-11-25(30-18)36-19-12-13-28-15-19/h3-11,14,16,19,28H,2,12-13,15,17H2,1H3,(H,31,35)
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n/an/a 1.40E+3n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131923
PNG
(US8841455, 18)
Show SMILES CCc1nn(Cc2cccc(OC3CCNC[C@H]3F)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C28H28FN7O2/c1-2-20-27-21(33-28(37)23-16-31-25-10-3-4-14-35(23)25)8-6-9-22(27)36(34-20)17-18-7-5-11-26(32-18)38-24-12-13-30-15-19(24)29/h3-11,14,16,19,24,30H,2,12-13,15,17H2,1H3,(H,33,37)/t19-,24?/m1/s1
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n/an/a 1.14E+3n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131924
PNG
(US8841455, 19)
Show SMILES CCc1nn(Cc2cccc(OC3CCNCC3)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C28H29N7O2/c1-2-21-27-22(32-28(36)24-17-30-25-10-3-4-16-34(24)25)8-6-9-23(27)35(33-21)18-19-7-5-11-26(31-19)37-20-12-14-29-15-13-20/h3-11,16-17,20,29H,2,12-15,18H2,1H3,(H,32,36)
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n/an/a 860n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131925
PNG
(US8841455, 20)
Show SMILES CCc1nn(Cc2cnn(Cc3ccc(OC)cc3)c2)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C29H27N7O2/c1-3-23-28-24(32-29(37)26-16-30-27-9-4-5-14-35(26)27)7-6-8-25(28)36(33-23)19-21-15-31-34(18-21)17-20-10-12-22(38-2)13-11-20/h4-16,18H,3,17,19H2,1-2H3,(H,32,37)
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n/an/a 1.04E+3n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131926
PNG
(US8841455, 21)
Show SMILES CCc1nn(Cc2cnn(CCO)c2)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C23H23N7O2/c1-2-17-22-18(26-23(32)20-13-24-21-8-3-4-9-29(20)21)6-5-7-19(22)30(27-17)15-16-12-25-28(14-16)10-11-31/h3-9,12-14,31H,2,10-11,15H2,1H3,(H,26,32)
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n/an/a 2.91E+3n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131927
PNG
(US8841455, 22)
Show SMILES CCc1nn(Cc2cnn(c2)C2CCNC[C@H]2F)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C26H27FN8O/c1-2-19-25-20(31-26(36)23-14-29-24-8-3-4-11-33(23)24)6-5-7-22(25)35(32-19)16-17-12-30-34(15-17)21-9-10-28-13-18(21)27/h3-8,11-12,14-15,18,21,28H,2,9-10,13,16H2,1H3,(H,31,36)/t18-,21?/m1/s1
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n/an/a 2.26E+3n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131928
PNG
(US8841455, 23)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(CC)ccn34)c12
Show InChI InChI=1S/C26H26N6O/c1-4-18-12-13-31-23(15-27-24(31)14-18)26(33)29-21-10-7-11-22-25(21)20(5-2)30-32(22)16-19-9-6-8-17(3)28-19/h6-15H,4-5,16H2,1-3H3,(H,29,33)
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n/an/a 141n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131929
PNG
(US8841455, 24)
Show SMILES CCc1nn(Cc2cccc(CC)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C25H24N6O/c1-3-17-9-7-10-18(27-17)16-31-21-12-8-11-20(24(21)19(4-2)29-31)28-25(32)22-15-26-23-13-5-6-14-30(22)23/h5-15H,3-4,16H2,1-2H3,(H,28,32)
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n/an/a 410n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131930
PNG
(US8841455, 25)
Show SMILES CCc1nn(Cc2cccc(=O)n2C)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C24H22N6O2/c1-3-17-23-18(26-24(32)20-14-25-21-11-4-5-13-29(20)21)9-7-10-19(23)30(27-17)15-16-8-6-12-22(31)28(16)2/h4-14H,3,15H2,1-2H3,(H,26,32)
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n/an/a 1.97E+3n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131931
PNG
(US8841455, 26)
Show SMILES CCc1nn(Cc2cccc(=O)n2CC)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C25H24N6O2/c1-3-18-24-19(27-25(33)21-15-26-22-12-5-6-14-30(21)22)10-8-11-20(24)31(28-18)16-17-9-7-13-23(32)29(17)4-2/h5-15H,3-4,16H2,1-2H3,(H,27,33)
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n/an/a 4.91E+3n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131932
PNG
(US8841455, 27)
Show SMILES CCOc1cccc(Cn2nc(CC)c3c(NC(=O)c4cnc5ccccn45)cccc23)n1
Show InChI InChI=1S/C25H24N6O2/c1-3-18-24-19(28-25(32)21-15-26-22-12-5-6-14-30(21)22)10-8-11-20(24)31(29-18)16-17-9-7-13-23(27-17)33-4-2/h5-15H,3-4,16H2,1-2H3,(H,28,32)
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n/an/a 101n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131933
PNG
(US8841455, 28)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(ccn34)-c3nnco3)c12
Show InChI InChI=1S/C26H22N8O2/c1-3-19-24-20(8-5-9-21(24)34(32-19)14-18-7-4-6-16(2)29-18)30-25(35)22-13-27-23-12-17(10-11-33(22)23)26-31-28-15-36-26/h4-13,15H,3,14H2,1-2H3,(H,30,35)
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n/an/a 176n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131934
PNG
(US8841455, 29)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(ccn34)-c3nnc(C)o3)c12
Show InChI InChI=1S/C27H24N8O2/c1-4-20-25-21(9-6-10-22(25)35(33-20)15-19-8-5-7-16(2)29-19)30-26(36)23-14-28-24-13-18(11-12-34(23)24)27-32-31-17(3)37-27/h5-14H,4,15H2,1-3H3,(H,30,36)
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n/an/a 556n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
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