Compile Data Set for Download or QSAR

Found 1911 hits Enz. Inhib. hit(s) with Target = 'Macrophage colony-stimulating factor 1 receptor (CSF1R)'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM276741 (US10071991, Compound (I-M2) | US9611259, Compound ...) Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1CC(C)(C)OC(C)(C1)C(O)=O Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	7.0	25
Janssen Pharmaceutica NV US Patent					Assay Description c-fms(h) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKSPGEYVNIEFG, 10 mM MgAcetate and [γ-33P-ATP] (specific activity approx...				US Patent US10071991 (2018) BindingDB Entry DOI: 10.7270/Q2W95C6X
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM276742 (US10071991, Compound (I-M7) | US9611259, Compound ...) Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1CC(C)(C)OC(C)(CO)C1 Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	7.0	25
Janssen Pharmaceutica NV US Patent					Assay Description c-fms(h) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKSPGEYVNIEFG, 10 mM MgAcetate and [γ-33P-ATP] (specific activity approx...				US Patent US10071991 (2018) BindingDB Entry DOI: 10.7270/Q2W95C6X
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM276743 (US10071991, Compound (P) | US9611259, Compound (P)) Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1CC(C)(C)OC(C)(C)C1 Show InChI InChI=1S/C27H35N5O2/c1-25(2)11-9-17(10-12-25)22-21(32-24(33)23-29-16-19(15-28)30-23)8-7-20(31-22)18-13-26(3,4)34-27(5,6)14-18/h7-9,16,18H,10-14H2,1-6H3,(H,29,30)(H,32,33)	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	7.0	25
Janssen Pharmaceutica NV US Patent					Assay Description c-fms(h) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKSPGEYVNIEFG, 10 mM MgAcetate and [γ-33P-ATP] (specific activity approx...				US Patent US10071991 (2018) BindingDB Entry DOI: 10.7270/Q2W95C6X
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM276743 (US10071991, Compound (P) | US9611259, Compound (P)) Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1CC(C)(C)OC(C)(C)C1 Show InChI InChI=1S/C27H35N5O2/c1-25(2)11-9-17(10-12-25)22-21(32-24(33)23-29-16-19(15-28)30-23)8-7-20(31-22)18-13-26(3,4)34-27(5,6)14-18/h7-9,16,18H,10-14H2,1-6H3,(H,29,30)(H,32,33)	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	7.0	25
Janssen Pharmaceutica NV US Patent					Assay Description In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...				US Patent US10071991 (2018) BindingDB Entry DOI: 10.7270/Q2W95C6X
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM276745 (US10071991, Compound (I-M2-2R,4S)) Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)[C@H]1CC(C)(C)O[C@](C)(C1)C(O)=O Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	7.0	25
Janssen Pharmaceutica NV US Patent					Assay Description In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...				US Patent US10071991 (2018) BindingDB Entry DOI: 10.7270/Q2W95C6X
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM276746 (US10071991, Compound (I-M7-2S,4R)) Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)[C@@H]1CC(C)(C)O[C@](C)(CO)C1 Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	7.90	n/a	n/a	n/a	n/a	7.0	25
Janssen Pharmaceutica NV US Patent					Assay Description In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...				US Patent US10071991 (2018) BindingDB Entry DOI: 10.7270/Q2W95C6X
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM276747 (US10071991, Compound (I-M7-2R,4S)) Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)[C@H]1CC(C)(C)O[C@](C)(CO)C1 Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	7.10	n/a	n/a	n/a	n/a	7.0	25
Janssen Pharmaceutica NV US Patent					Assay Description In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...				US Patent US10071991 (2018) BindingDB Entry DOI: 10.7270/Q2W95C6X
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM276744 (US10071991, Compound (I-M2-2S,4R)) Show SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)[C@@H]1CC(C)(C)O[C@@](C)(C1)C(O)=O Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	2.20	n/a	n/a	n/a	n/a	7.0	25
Janssen Pharmaceutica NV US Patent					Assay Description In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...				US Patent US10071991 (2018) BindingDB Entry DOI: 10.7270/Q2W95C6X
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM50381716 (ABT-348 | ILORASERTIB | US8722890, 1 | US8722890, ...) Show SMILES Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 Show InChI InChI=1S/C25H21FN6O2S/c26-17-2-1-3-19(10-17)31-25(34)30-18-6-4-15(5-7-18)21-14-35-23-20(12-28-24(27)22(21)23)16-11-29-32(13-16)8-9-33/h1-7,10-14,33H,8-9H2,(H2,27,28)(H2,30,31,34)	UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.42	n/a	n/a	n/a	n/a	7.1	25
AbbVie Inc US Patent					Assay Description To determine the activity of the various kinases, a homogenous time-resolved fluorescence (HTRF) in vitro kinase assay was used. (Mathis, G., HTRF(R)...				US Patent US8722890 (2014) BindingDB Entry DOI: 10.7270/Q21Z4327
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM50381716 (ABT-348 | ILORASERTIB | US8722890, 1 | US8722890, ...) Show SMILES Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 Show InChI InChI=1S/C25H21FN6O2S/c26-17-2-1-3-19(10-17)31-25(34)30-18-6-4-15(5-7-18)21-14-35-23-20(12-28-24(27)22(21)23)16-11-29-32(13-16)8-9-33/h1-7,10-14,33H,8-9H2,(H2,27,28)(H2,30,31,34)	UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.22	n/a	n/a	n/a	n/a	7.1	25
AbbVie Inc US Patent					Assay Description To determine the activity of the various kinases, a homogenous time-resolved fluorescence (HTRF) in vitro kinase assay was used. (Mathis, G., HTRF(R)...				US Patent US8722890 (2014) BindingDB Entry DOI: 10.7270/Q21Z4327
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM50381698 (CHEMBL1969102 | US8722890, 6) Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3c(cnc(N)c23)-c2cn[nH]c2)c1 Show InChI InChI=1S/C24H20N6OS/c1-14-3-2-4-18(9-14)30-24(31)29-17-7-5-15(6-8-17)20-13-32-22-19(16-10-27-28-11-16)12-26-23(25)21(20)22/h2-13H,1H3,(H2,25,26)(H,27,28)(H2,29,30,31)	UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.74	n/a	n/a	n/a	n/a	7.1	25
AbbVie Inc US Patent					Assay Description To determine the activity of the various kinases, a homogenous time-resolved fluorescence (HTRF) in vitro kinase assay was used. (Mathis, G., HTRF(R)...				US Patent US8722890 (2014) BindingDB Entry DOI: 10.7270/Q21Z4327
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM121389 (US8722890, 4) Show SMILES COc1ccc(NC(=O)Nc2ccc(cc2)-c2csc3c(cnc(N)c23)-c2cnn(CC(C)(C)O)c2)cc1 Show InChI InChI=1S/C28H28N6O3S/c1-28(2,36)16-34-14-18(12-31-34)22-13-30-26(29)24-23(15-38-25(22)24)17-4-6-19(7-5-17)32-27(35)33-20-8-10-21(37-3)11-9-20/h4-15,36H,16H2,1-3H3,(H2,29,30)(H2,32,33,35)	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.87	n/a	n/a	n/a	n/a	7.1	25
AbbVie Inc US Patent					Assay Description To determine the activity of the various kinases, a homogenous time-resolved fluorescence (HTRF) in vitro kinase assay was used. (Mathis, G., HTRF(R)...				US Patent US8722890 (2014) BindingDB Entry DOI: 10.7270/Q21Z4327
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM121390 (US8722890, 5) Show SMILES COc1ccc(NC(=O)Nc2ccc(cc2)-c2csc3c(cnc(N)c23)-c2cnn(C[C@H](O)CO)c2)cc1 Show InChI InChI=1S/C27H26N6O4S/c1-37-21-8-6-19(7-9-21)32-27(36)31-18-4-2-16(3-5-18)23-15-38-25-22(11-29-26(28)24(23)25)17-10-30-33(12-17)13-20(35)14-34/h2-12,15,20,34-35H,13-14H2,1H3,(H2,28,29)(H2,31,32,36)/t20-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.34	n/a	n/a	n/a	n/a	7.1	25
AbbVie Inc US Patent					Assay Description To determine the activity of the various kinases, a homogenous time-resolved fluorescence (HTRF) in vitro kinase assay was used. (Mathis, G., HTRF(R)...				US Patent US8722890 (2014) BindingDB Entry DOI: 10.7270/Q21Z4327
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM121388 (US8722890, 3) Show SMILES C[C@H](O)Cn1cc(cn1)-c1cnc(N)c2c(csc12)-c1ccc(NC(=O)Nc2cccc(C)c2)cc1 Show InChI InChI=1S/C27H26N6O2S/c1-16-4-3-5-21(10-16)32-27(35)31-20-8-6-18(7-9-20)23-15-36-25-22(12-29-26(28)24(23)25)19-11-30-33(14-19)13-17(2)34/h3-12,14-15,17,34H,13H2,1-2H3,(H2,28,29)(H2,31,32,35)/t17-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.62	n/a	n/a	n/a	n/a	7.1	25
AbbVie Inc US Patent					Assay Description To determine the activity of the various kinases, a homogenous time-resolved fluorescence (HTRF) in vitro kinase assay was used. (Mathis, G., HTRF(R)...				US Patent US8722890 (2014) BindingDB Entry DOI: 10.7270/Q21Z4327
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM131913 (US8841455, 8) Show SMILES CCc1nn(Cc2ccnn2CC(O)CO)c2cccc(NC(=O)c3cnc4ccccn34)c12 Show InChI InChI=1S/C24H25N7O3/c1-2-18-23-19(27-24(34)21-12-25-22-8-3-4-11-29(21)22)6-5-7-20(23)31(28-18)13-16-9-10-26-30(16)14-17(33)15-32/h3-12,17,32-33H,2,13-15H2,1H3,(H,27,34)	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	7.3	22
Array BioPharma Inc US Patent					Assay Description The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...				US Patent US8841455 (2014) BindingDB Entry DOI: 10.7270/Q2125RB3
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM131914 (US8841455, 9) Show SMILES CCc1nn(Cc2cccc(OCCN)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12 Show InChI InChI=1S/C25H25N7O2/c1-2-18-24-19(29-25(33)21-15-27-22-10-3-4-13-31(21)22)8-6-9-20(24)32(30-18)16-17-7-5-11-23(28-17)34-14-12-26/h3-11,13,15H,2,12,14,16,26H2,1H3,(H,29,33)	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	455	n/a	n/a	n/a	n/a	7.3	22
Array BioPharma Inc US Patent					Assay Description The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...				US Patent US8841455 (2014) BindingDB Entry DOI: 10.7270/Q2125RB3
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM131915 (US8841455, 10) Show SMILES CCc1nn(Cc2cccc(OCCCN)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12 Show InChI InChI=1S/C26H27N7O2/c1-2-19-25-20(30-26(34)22-16-28-23-11-3-4-14-32(22)23)9-6-10-21(25)33(31-19)17-18-8-5-12-24(29-18)35-15-7-13-27/h3-6,8-12,14,16H,2,7,13,15,17,27H2,1H3,(H,30,34)	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	395	n/a	n/a	n/a	n/a	7.3	22
Array BioPharma Inc US Patent					Assay Description The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...				US Patent US8841455 (2014) BindingDB Entry DOI: 10.7270/Q2125RB3
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM131916 (US8841455, 11) Show SMILES CCc1nn(Cc2cccc(OCCCN(C)C)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12 Show InChI InChI=1S/C28H31N7O2/c1-4-21-27-22(31-28(36)24-18-29-25-13-5-6-16-34(24)25)11-8-12-23(27)35(32-21)19-20-10-7-14-26(30-20)37-17-9-15-33(2)3/h5-8,10-14,16,18H,4,9,15,17,19H2,1-3H3,(H,31,36)	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.88E+3	n/a	n/a	n/a	n/a	7.3	22
Array BioPharma Inc US Patent					Assay Description The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...				US Patent US8841455 (2014) BindingDB Entry DOI: 10.7270/Q2125RB3
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM131917 (US8841455, 12) Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(ccn34)C(=O)N3CCNCC3)c12 Show InChI InChI=1S/C29H30N8O2/c1-3-22-27-23(8-5-9-24(27)37(34-22)18-21-7-4-6-19(2)32-21)33-28(38)25-17-31-26-16-20(10-13-36(25)26)29(39)35-14-11-30-12-15-35/h4-10,13,16-17,30H,3,11-12,14-15,18H2,1-2H3,(H,33,38)	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	903	n/a	n/a	n/a	n/a	7.3	22
Array BioPharma Inc US Patent					Assay Description The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...				US Patent US8841455 (2014) BindingDB Entry DOI: 10.7270/Q2125RB3
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM131918 (US8841455, 13) Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(ccn34)C(=O)N3CCN(C)CC3)c12 Show InChI InChI=1S/C30H32N8O2/c1-4-23-28-24(9-6-10-25(28)38(34-23)19-22-8-5-7-20(2)32-22)33-29(39)26-18-31-27-17-21(11-12-37(26)27)30(40)36-15-13-35(3)14-16-36/h5-12,17-18H,4,13-16,19H2,1-3H3,(H,33,39)	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.56E+3	n/a	n/a	n/a	n/a	7.3	22
Array BioPharma Inc US Patent					Assay Description The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...				US Patent US8841455 (2014) BindingDB Entry DOI: 10.7270/Q2125RB3
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM131919 (US8841455, 14) Show SMILES CCc1nn(Cc2cccc(CN3CCNCC3)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12 Show InChI InChI=1S/C28H30N8O/c1-2-22-27-23(32-28(37)25-17-30-26-11-3-4-14-35(25)26)9-6-10-24(27)36(33-22)19-21-8-5-7-20(31-21)18-34-15-12-29-13-16-34/h3-11,14,17,29H,2,12-13,15-16,18-19H2,1H3,(H,32,37)	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.84E+3	n/a	n/a	n/a	n/a	7.3	22
Array BioPharma Inc US Patent					Assay Description The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...				US Patent US8841455 (2014) BindingDB Entry DOI: 10.7270/Q2125RB3
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM131920 (US8841455, 15) Show SMILES CCc1nn(Cc2cccc(OC)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12 Show InChI InChI=1S/C24H22N6O2/c1-3-17-23-18(27-24(31)20-14-25-21-11-4-5-13-29(20)21)9-7-10-19(23)30(28-17)15-16-8-6-12-22(26-16)32-2/h4-14H,3,15H2,1-2H3,(H,27,31)	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	138	n/a	n/a	n/a	n/a	7.3	22
Array BioPharma Inc US Patent					Assay Description The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...				US Patent US8841455 (2014) BindingDB Entry DOI: 10.7270/Q2125RB3
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM131921 (US8841455, 16) Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(OCCN5CCOCC5)ccn34)c12 Show InChI InChI=1S/C30H33N7O3/c1-3-24-29-25(8-5-9-26(29)37(34-24)20-22-7-4-6-21(2)32-22)33-30(38)27-19-31-28-18-23(10-11-36(27)28)40-17-14-35-12-15-39-16-13-35/h4-11,18-19H,3,12-17,20H2,1-2H3,(H,33,38)	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	145	n/a	n/a	n/a	n/a	7.3	22
Array BioPharma Inc US Patent					Assay Description The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...				US Patent US8841455 (2014) BindingDB Entry DOI: 10.7270/Q2125RB3
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM131922 (US8841455, 17) Show SMILES CCc1nn(Cc2cccc(OC3CCNC3)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12 Show InChI InChI=1S/C27H27N7O2/c1-2-20-26-21(31-27(35)23-16-29-24-10-3-4-14-33(23)24)8-6-9-22(26)34(32-20)17-18-7-5-11-25(30-18)36-19-12-13-28-15-19/h3-11,14,16,19,28H,2,12-13,15,17H2,1H3,(H,31,35)	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	7.3	22
Array BioPharma Inc US Patent					Assay Description The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...				US Patent US8841455 (2014) BindingDB Entry DOI: 10.7270/Q2125RB3
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM131923 (US8841455, 18) Show SMILES CCc1nn(Cc2cccc(OC3CCNC[C@H]3F)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12 Show InChI InChI=1S/C28H28FN7O2/c1-2-20-27-21(33-28(37)23-16-31-25-10-3-4-14-35(23)25)8-6-9-22(27)36(34-20)17-18-7-5-11-26(32-18)38-24-12-13-30-15-19(24)29/h3-11,14,16,19,24,30H,2,12-13,15,17H2,1H3,(H,33,37)/t19-,24?/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.14E+3	n/a	n/a	n/a	n/a	7.3	22
Array BioPharma Inc US Patent					Assay Description The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...				US Patent US8841455 (2014) BindingDB Entry DOI: 10.7270/Q2125RB3
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM131924 (US8841455, 19) Show SMILES CCc1nn(Cc2cccc(OC3CCNCC3)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12 Show InChI InChI=1S/C28H29N7O2/c1-2-21-27-22(32-28(36)24-17-30-25-10-3-4-16-34(24)25)8-6-9-23(27)35(33-21)18-19-7-5-11-26(31-19)37-20-12-14-29-15-13-20/h3-11,16-17,20,29H,2,12-15,18H2,1H3,(H,32,36)	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	860	n/a	n/a	n/a	n/a	7.3	22
Array BioPharma Inc US Patent					Assay Description The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...				US Patent US8841455 (2014) BindingDB Entry DOI: 10.7270/Q2125RB3
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM131925 (US8841455, 20) Show SMILES CCc1nn(Cc2cnn(Cc3ccc(OC)cc3)c2)c2cccc(NC(=O)c3cnc4ccccn34)c12 Show InChI InChI=1S/C29H27N7O2/c1-3-23-28-24(32-29(37)26-16-30-27-9-4-5-14-35(26)27)7-6-8-25(28)36(33-23)19-21-15-31-34(18-21)17-20-10-12-22(38-2)13-11-20/h4-16,18H,3,17,19H2,1-2H3,(H,32,37)	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.04E+3	n/a	n/a	n/a	n/a	7.3	22
Array BioPharma Inc US Patent					Assay Description The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...				US Patent US8841455 (2014) BindingDB Entry DOI: 10.7270/Q2125RB3
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM131926 (US8841455, 21) Show SMILES CCc1nn(Cc2cnn(CCO)c2)c2cccc(NC(=O)c3cnc4ccccn34)c12 Show InChI InChI=1S/C23H23N7O2/c1-2-17-22-18(26-23(32)20-13-24-21-8-3-4-9-29(20)21)6-5-7-19(22)30(27-17)15-16-12-25-28(14-16)10-11-31/h3-9,12-14,31H,2,10-11,15H2,1H3,(H,26,32)	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.91E+3	n/a	n/a	n/a	n/a	7.3	22
Array BioPharma Inc US Patent					Assay Description The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...				US Patent US8841455 (2014) BindingDB Entry DOI: 10.7270/Q2125RB3
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM131927 (US8841455, 22) Show SMILES CCc1nn(Cc2cnn(c2)C2CCNC[C@H]2F)c2cccc(NC(=O)c3cnc4ccccn34)c12 Show InChI InChI=1S/C26H27FN8O/c1-2-19-25-20(31-26(36)23-14-29-24-8-3-4-11-33(23)24)6-5-7-22(25)35(32-19)16-17-12-30-34(15-17)21-9-10-28-13-18(21)27/h3-8,11-12,14-15,18,21,28H,2,9-10,13,16H2,1H3,(H,31,36)/t18-,21?/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.26E+3	n/a	n/a	n/a	n/a	7.3	22
Array BioPharma Inc US Patent					Assay Description The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...				US Patent US8841455 (2014) BindingDB Entry DOI: 10.7270/Q2125RB3
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM131928 (US8841455, 23) Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(CC)ccn34)c12 Show InChI InChI=1S/C26H26N6O/c1-4-18-12-13-31-23(15-27-24(31)14-18)26(33)29-21-10-7-11-22-25(21)20(5-2)30-32(22)16-19-9-6-8-17(3)28-19/h6-15H,4-5,16H2,1-3H3,(H,29,33)	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	141	n/a	n/a	n/a	n/a	7.3	22
Array BioPharma Inc US Patent					Assay Description The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...				US Patent US8841455 (2014) BindingDB Entry DOI: 10.7270/Q2125RB3
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM131929 (US8841455, 24) Show SMILES CCc1nn(Cc2cccc(CC)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12 Show InChI InChI=1S/C25H24N6O/c1-3-17-9-7-10-18(27-17)16-31-21-12-8-11-20(24(21)19(4-2)29-31)28-25(32)22-15-26-23-13-5-6-14-30(22)23/h5-15H,3-4,16H2,1-2H3,(H,28,32)	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	410	n/a	n/a	n/a	n/a	7.3	22
Array BioPharma Inc US Patent					Assay Description The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...				US Patent US8841455 (2014) BindingDB Entry DOI: 10.7270/Q2125RB3
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM131930 (US8841455, 25) Show SMILES CCc1nn(Cc2cccc(=O)n2C)c2cccc(NC(=O)c3cnc4ccccn34)c12 Show InChI InChI=1S/C24H22N6O2/c1-3-17-23-18(26-24(32)20-14-25-21-11-4-5-13-29(20)21)9-7-10-19(23)30(27-17)15-16-8-6-12-22(31)28(16)2/h4-14H,3,15H2,1-2H3,(H,26,32)	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.97E+3	n/a	n/a	n/a	n/a	7.3	22
Array BioPharma Inc US Patent					Assay Description The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...				US Patent US8841455 (2014) BindingDB Entry DOI: 10.7270/Q2125RB3
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM131931 (US8841455, 26) Show SMILES CCc1nn(Cc2cccc(=O)n2CC)c2cccc(NC(=O)c3cnc4ccccn34)c12 Show InChI InChI=1S/C25H24N6O2/c1-3-18-24-19(27-25(33)21-15-26-22-12-5-6-14-30(21)22)10-8-11-20(24)31(28-18)16-17-9-7-13-23(32)29(17)4-2/h5-15H,3-4,16H2,1-2H3,(H,27,33)	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.91E+3	n/a	n/a	n/a	n/a	7.3	22
Array BioPharma Inc US Patent					Assay Description The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...				US Patent US8841455 (2014) BindingDB Entry DOI: 10.7270/Q2125RB3
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM131932 (US8841455, 27) Show SMILES CCOc1cccc(Cn2nc(CC)c3c(NC(=O)c4cnc5ccccn45)cccc23)n1 Show InChI InChI=1S/C25H24N6O2/c1-3-18-24-19(28-25(32)21-15-26-22-12-5-6-14-30(21)22)10-8-11-20(24)31(29-18)16-17-9-7-13-23(27-17)33-4-2/h5-15H,3-4,16H2,1-2H3,(H,28,32)	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	101	n/a	n/a	n/a	n/a	7.3	22
Array BioPharma Inc US Patent					Assay Description The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...				US Patent US8841455 (2014) BindingDB Entry DOI: 10.7270/Q2125RB3
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM131933 (US8841455, 28) Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(ccn34)-c3nnco3)c12 Show InChI InChI=1S/C26H22N8O2/c1-3-19-24-20(8-5-9-21(24)34(32-19)14-18-7-4-6-16(2)29-18)30-25(35)22-13-27-23-12-17(10-11-33(22)23)26-31-28-15-36-26/h4-13,15H,3,14H2,1-2H3,(H,30,35)	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	176	n/a	n/a	n/a	n/a	7.3	22
Array BioPharma Inc US Patent					Assay Description The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...				US Patent US8841455 (2014) BindingDB Entry DOI: 10.7270/Q2125RB3
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM131934 (US8841455, 29) Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(ccn34)-c3nnc(C)o3)c12 Show InChI InChI=1S/C27H24N8O2/c1-4-20-25-21(9-6-10-22(25)35(33-20)15-19-8-5-7-16(2)29-19)30-26(36)23-14-28-24-13-18(11-12-34(23)24)27-32-31-17(3)37-27/h5-14H,4,15H2,1-3H3,(H,30,36)	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	556	n/a	n/a	n/a	n/a	7.3	22
Array BioPharma Inc US Patent					Assay Description The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...				US Patent US8841455 (2014) BindingDB Entry DOI: 10.7270/Q2125RB3
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM131935 (US8841455, 30) Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(CN5CCNCC5)ccn34)c12 Show InChI InChI=1S/C29H32N8O/c1-3-23-28-24(8-5-9-25(28)37(34-23)19-22-7-4-6-20(2)32-22)33-29(38)26-17-31-27-16-21(10-13-36(26)27)18-35-14-11-30-12-15-35/h4-10,13,16-17,30H,3,11-12,14-15,18-19H2,1-2H3,(H,33,38)	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	191	n/a	n/a	n/a	n/a	7.3	22
Array BioPharma Inc US Patent					Assay Description The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...				US Patent US8841455 (2014) BindingDB Entry DOI: 10.7270/Q2125RB3
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM131936 (US8841455, 31) Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(CN5CCN(C)CC5)ccn34)c12 Show InChI InChI=1S/C30H34N8O/c1-4-24-29-25(9-6-10-26(29)38(34-24)20-23-8-5-7-21(2)32-23)33-30(39)27-18-31-28-17-22(11-12-37(27)28)19-36-15-13-35(3)14-16-36/h5-12,17-18H,4,13-16,19-20H2,1-3H3,(H,33,39)	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	333	n/a	n/a	n/a	n/a	7.3	22
Array BioPharma Inc US Patent					Assay Description The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...				US Patent US8841455 (2014) BindingDB Entry DOI: 10.7270/Q2125RB3
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM131937 (US8841455, 32) Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(O[C@H]5CNC[C@@H]5O)ccn34)c12 Show InChI InChI=1S/C28H29N7O3/c1-3-20-27-21(8-5-9-22(27)35(33-20)16-18-7-4-6-17(2)31-18)32-28(37)23-13-30-26-12-19(10-11-34(23)26)38-25-15-29-14-24(25)36/h4-13,24-25,29,36H,3,14-16H2,1-2H3,(H,32,37)/t24-,25-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	342	n/a	n/a	n/a	n/a	7.3	22
Array BioPharma Inc US Patent					Assay Description The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...				US Patent US8841455 (2014) BindingDB Entry DOI: 10.7270/Q2125RB3
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM131938 (US8841455, 33) Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(O[C@@H]5CNC[C@H]5O)ccn34)c12 Show InChI InChI=1S/C28H29N7O3/c1-3-20-27-21(8-5-9-22(27)35(33-20)16-18-7-4-6-17(2)31-18)32-28(37)23-13-30-26-12-19(10-11-34(23)26)38-25-15-29-14-24(25)36/h4-13,24-25,29,36H,3,14-16H2,1-2H3,(H,32,37)/t24-,25-/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	287	n/a	n/a	n/a	n/a	7.3	22
Array BioPharma Inc US Patent					Assay Description The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...				US Patent US8841455 (2014) BindingDB Entry DOI: 10.7270/Q2125RB3
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM131939 (US8841455, 34) Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(O[C@H]5CN(C)C[C@@H]5O)ccn34)c12 Show InChI InChI=1S/C29H31N7O3/c1-4-21-28-22(9-6-10-23(28)36(33-21)15-19-8-5-7-18(2)31-19)32-29(38)24-14-30-27-13-20(11-12-35(24)27)39-26-17-34(3)16-25(26)37/h5-14,25-26,37H,4,15-17H2,1-3H3,(H,32,38)/t25-,26-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	689	n/a	n/a	n/a	n/a	7.3	22
Array BioPharma Inc US Patent					Assay Description The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...				US Patent US8841455 (2014) BindingDB Entry DOI: 10.7270/Q2125RB3
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM131940 (US8841455, 35) Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(O[C@@H]5CN(C)C[C@H]5O)ccn34)c12 Show InChI InChI=1S/C29H31N7O3/c1-4-21-28-22(9-6-10-23(28)36(33-21)15-19-8-5-7-18(2)31-19)32-29(38)24-14-30-27-13-20(11-12-35(24)27)39-26-17-34(3)16-25(26)37/h5-14,25-26,37H,4,15-17H2,1-3H3,(H,32,38)/t25-,26-/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	488	n/a	n/a	n/a	n/a	7.3	22
Array BioPharma Inc US Patent					Assay Description The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...				US Patent US8841455 (2014) BindingDB Entry DOI: 10.7270/Q2125RB3
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM131941 (US8841455, 36) Show SMILES CCc1nn(Cc2cccc(OC[C@H]3NCC[C@@H]3O)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12 Show InChI InChI=1S/C28H29N7O3/c1-2-19-27-20(32-28(37)23-15-30-25-10-3-4-14-34(23)25)8-6-9-22(27)35(33-19)16-18-7-5-11-26(31-18)38-17-21-24(36)12-13-29-21/h3-11,14-15,21,24,29,36H,2,12-13,16-17H2,1H3,(H,32,37)/t21-,24+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	555	n/a	n/a	n/a	n/a	7.3	22
Array BioPharma Inc US Patent					Assay Description The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...				US Patent US8841455 (2014) BindingDB Entry DOI: 10.7270/Q2125RB3
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM131942 (US8841455, 37) Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(OCCN5CC[N+](C)([O-])CC5)ccn34)c12 Show InChI InChI=1S/C31H36N8O3/c1-4-25-30-26(9-6-10-27(30)38(35-25)21-23-8-5-7-22(2)33-23)34-31(40)28-20-32-29-19-24(11-12-37(28)29)42-18-15-36-13-16-39(3,41)17-14-36/h5-12,19-20H,4,13-18,21H2,1-3H3,(H,34,40)	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	725	n/a	n/a	n/a	n/a	7.3	22
Array BioPharma Inc US Patent					Assay Description The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...				US Patent US8841455 (2014) BindingDB Entry DOI: 10.7270/Q2125RB3
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM131943 (US8841455, 38) Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(OC[C@H]5NCC[C@@H]5O)ccn34)c12 Show InChI InChI=1S/C29H31N7O3/c1-3-21-28-22(8-5-9-24(28)36(34-21)16-19-7-4-6-18(2)32-19)33-29(38)25-15-31-27-14-20(11-13-35(25)27)39-17-23-26(37)10-12-30-23/h4-9,11,13-15,23,26,30,37H,3,10,12,16-17H2,1-2H3,(H,33,38)/t23-,26+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	98.3	n/a	n/a	n/a	n/a	7.3	22
Array BioPharma Inc US Patent					Assay Description The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...				US Patent US8841455 (2014) BindingDB Entry DOI: 10.7270/Q2125RB3
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM131944 (US8841455, 39) Show SMILES CCc1nn(Cc2ccnn2CC)c2cccc(NC(=O)c3cnc4ccccn34)c12 Show InChI InChI=1S/C23H23N7O/c1-3-17-22-18(26-23(31)20-14-24-21-10-5-6-13-28(20)21)8-7-9-19(22)30(27-17)15-16-11-12-25-29(16)4-2/h5-14H,3-4,15H2,1-2H3,(H,26,31)	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	332	n/a	n/a	n/a	n/a	7.3	22
Array BioPharma Inc US Patent					Assay Description The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...				US Patent US8841455 (2014) BindingDB Entry DOI: 10.7270/Q2125RB3
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM131945 (US8841455, 40) Show SMILES CCc1nn(Cc2ccn(CC)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12 Show InChI InChI=1S/C23H23N7O/c1-3-17-22-18(25-23(31)20-14-24-21-10-5-6-12-29(20)21)8-7-9-19(22)30(27-17)15-16-11-13-28(4-2)26-16/h5-14H,3-4,15H2,1-2H3,(H,25,31)	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	359	n/a	n/a	n/a	n/a	7.3	22
Array BioPharma Inc US Patent					Assay Description The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...				US Patent US8841455 (2014) BindingDB Entry DOI: 10.7270/Q2125RB3
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM131946 (US8841455, 41) Show SMILES CCc1nn(Cc2cccc(OC[C@@H]3[C@@H](O)CCN3C)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12 Show InChI InChI=1S/C29H31N7O3/c1-3-20-28-21(32-29(38)23-16-30-26-11-4-5-14-35(23)26)9-7-10-22(28)36(33-20)17-19-8-6-12-27(31-19)39-18-24-25(37)13-15-34(24)2/h4-12,14,16,24-25,37H,3,13,15,17-18H2,1-2H3,(H,32,38)/t24-,25+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	932	n/a	n/a	n/a	n/a	7.3	22
Array BioPharma Inc US Patent					Assay Description The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...				US Patent US8841455 (2014) BindingDB Entry DOI: 10.7270/Q2125RB3
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM131947 (US8841455, 42) Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(OC[C@@H]5[C@@H](O)CCN5C)ccn34)c12 Show InChI InChI=1S/C30H33N7O3/c1-4-22-29-23(9-6-10-24(29)37(34-22)17-20-8-5-7-19(2)32-20)33-30(39)25-16-31-28-15-21(11-14-36(25)28)40-18-26-27(38)12-13-35(26)3/h5-11,14-16,26-27,38H,4,12-13,17-18H2,1-3H3,(H,33,39)/t26-,27+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	275	n/a	n/a	n/a	n/a	7.3	22
Array BioPharma Inc US Patent					Assay Description The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...				US Patent US8841455 (2014) BindingDB Entry DOI: 10.7270/Q2125RB3
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) (Homo sapiens (Human))	BDBM131948 (US8841455, 43) Show SMILES CCc1nn(Cc2cccc(OCCN3CCNCC3)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12 Show InChI InChI=1S/C29H32N8O2/c1-2-22-28-23(33-29(38)25-19-31-26-10-3-4-14-36(25)26)8-6-9-24(28)37(34-22)20-21-7-5-11-27(32-21)39-18-17-35-15-12-30-13-16-35/h3-11,14,19,30H,2,12-13,15-18,20H2,1H3,(H,33,38)	UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	396	n/a	n/a	n/a	n/a	7.3	22
Array BioPharma Inc US Patent					Assay Description The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...				US Patent US8841455 (2014) BindingDB Entry DOI: 10.7270/Q2125RB3
					More data for this Ligand-Target Pair

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