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Compile Data Set for Download or QSAR

Found 93 hits Enz. Inhib. hit(s) with Target = 'Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198838
PNG
(US9221797, 1)
Show SMILES CC(C)(NS(C)(=O)=O)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C21H25N5O3S/c1-21(2,26-30(3,28)29)15-9-10-18(17(11-15)14-7-5-4-6-8-14)25-20(27)19-23-13-16(12-22)24-19/h7,9-11,13,26H,4-6,8H2,1-3H3,(H,23,24)(H,25,27)
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US Patent
n/an/a 4.70n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198839
PNG
(US9221797, 2)
Show SMILES CC(=C)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C20H20N4O/c1-13(2)15-8-9-18(17(10-15)14-6-4-3-5-7-14)24-20(25)19-22-12-16(11-21)23-19/h6,8-10,12H,1,3-5,7H2,2H3,(H,22,23)(H,24,25)
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n/an/a 32.9n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198840
PNG
(US9221797, 3)
Show SMILES CC(=O)NC(C)(C)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C22H25N5O2/c1-14(28)27-22(2,3)16-9-10-19(18(11-16)15-7-5-4-6-8-15)26-21(29)20-24-13-17(12-23)25-20/h7,9-11,13H,4-6,8H2,1-3H3,(H,24,25)(H,26,29)(H,27,28)
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n/an/a 6.10n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198841
PNG
(US9221797, 4)
Show SMILES CC(C)(NC(N)=O)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C21H24N6O2/c1-21(2,27-20(23)29)14-8-9-17(16(10-14)13-6-4-3-5-7-13)26-19(28)18-24-12-15(11-22)25-18/h6,8-10,12H,3-5,7H2,1-2H3,(H,24,25)(H,26,28)(H3,23,27,29)
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n/an/a 12.4n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198842
PNG
(US9221797, 5)
Show SMILES CC(C)(NC(=O)NCCO)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C23H28N6O3/c1-23(2,29-22(32)25-10-11-30)16-8-9-19(18(12-16)15-6-4-3-5-7-15)28-21(31)20-26-14-17(13-24)27-20/h6,8-9,12,14,30H,3-5,7,10-11H2,1-2H3,(H,26,27)(H,28,31)(H2,25,29,32)
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n/an/a 31.7n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198843
PNG
(US9221797, 6)
Show SMILES CC(C)(NC(=O)C(N)=O)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C22H24N6O3/c1-22(2,28-20(30)18(24)29)14-8-9-17(16(10-14)13-6-4-3-5-7-13)27-21(31)19-25-12-15(11-23)26-19/h6,8-10,12H,3-5,7H2,1-2H3,(H2,24,29)(H,25,26)(H,27,31)(H,28,30)
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n/an/a 8.60n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198844
PNG
(US9221797, 7)
Show SMILES NC(=O)CCc1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C20H21N5O2/c21-11-15-12-23-19(24-15)20(27)25-17-8-6-13(7-9-18(22)26)10-16(17)14-4-2-1-3-5-14/h4,6,8,10,12H,1-3,5,7,9H2,(H2,22,26)(H,23,24)(H,25,27)
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n/an/a 2.70n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198845
PNG
(US9221797, 8)
Show SMILES OC(=O)CCc1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C20H20N4O3/c21-11-15-12-22-19(23-15)20(27)24-17-8-6-13(7-9-18(25)26)10-16(17)14-4-2-1-3-5-14/h4,6,8,10,12H,1-3,5,7,9H2,(H,22,23)(H,24,27)(H,25,26)
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n/an/a 5.90n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198846
PNG
(US9221797, 9)
Show SMILES NC(=O)c1c[nH]c(n1)C(=O)Nc1ccc(CCC(O)=O)cc1C1=CCCCC1
Show InChI InChI=1S/C20H22N4O4/c21-18(27)16-11-22-19(23-16)20(28)24-15-8-6-12(7-9-17(25)26)10-14(15)13-4-2-1-3-5-13/h4,6,8,10-11H,1-3,5,7,9H2,(H2,21,27)(H,22,23)(H,24,28)(H,25,26)
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n/an/a 79n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198847
PNG
(US9221797, 10)
Show SMILES CC1(C)CCC(=CC1)c1cc(CCC(N)=O)ccc1NC(=O)c1nc(c[nH]1)C#N
Show InChI InChI=1S/C22H25N5O2/c1-22(2)9-7-15(8-10-22)17-11-14(4-6-19(24)28)3-5-18(17)27-21(29)20-25-13-16(12-23)26-20/h3,5,7,11,13H,4,6,8-10H2,1-2H3,(H2,24,28)(H,25,26)(H,27,29)
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n/an/a 1.70n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198848
PNG
(US9221797, 11)
Show SMILES OCC(CO)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C20H22N4O3/c21-9-16-10-22-19(23-16)20(27)24-18-7-6-14(15(11-25)12-26)8-17(18)13-4-2-1-3-5-13/h4,6-8,10,15,25-26H,1-3,5,11-12H2,(H,22,23)(H,24,27)
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n/an/a>60n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198849
PNG
(US9221797, 12)
Show SMILES CC(=O)OCC(COC(C)=O)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C24H26N4O5/c1-15(29)32-13-19(14-33-16(2)30)18-8-9-22(21(10-18)17-6-4-3-5-7-17)28-24(31)23-26-12-20(11-25)27-23/h6,8-10,12,19H,3-5,7,13-14H2,1-2H3,(H,26,27)(H,28,31)
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n/an/a 4.40n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198850
PNG
(US9221797, 13)
Show SMILES CC(C)(C(O)=O)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C21H22N4O3/c1-21(2,20(27)28)14-8-9-17(16(10-14)13-6-4-3-5-7-13)25-19(26)18-23-12-15(11-22)24-18/h6,8-10,12H,3-5,7H2,1-2H3,(H,23,24)(H,25,26)(H,27,28)
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n/an/a 8n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198851
PNG
(US9221797, 14)
Show SMILES CC(C)(N1CCSCC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C26H33N5OS/c1-25(2)9-7-18(8-10-25)21-15-19(26(3,4)31-11-13-33-14-12-31)5-6-22(21)30-24(32)23-28-17-20(16-27)29-23/h5-7,15,17H,8-14H2,1-4H3,(H,28,29)(H,30,32)
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n/an/a 9.30n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198852
PNG
(US9221797, 15)
Show SMILES CC(C)(N1CCS(=O)CC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C26H33N5O2S/c1-25(2)9-7-18(8-10-25)21-15-19(26(3,4)31-11-13-34(33)14-12-31)5-6-22(21)30-24(32)23-28-17-20(16-27)29-23/h5-7,15,17H,8-14H2,1-4H3,(H,28,29)(H,30,32)
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n/an/a 1.10n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198853
PNG
(US9221797, 16)
Show SMILES CC(C)(N1CCS(=O)(=O)CC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C26H33N5O3S/c1-25(2)9-7-18(8-10-25)21-15-19(26(3,4)31-11-13-35(33,34)14-12-31)5-6-22(21)30-24(32)23-28-17-20(16-27)29-23/h5-7,15,17H,8-14H2,1-4H3,(H,28,29)(H,30,32)
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n/an/a 3.30n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198854
PNG
(US9221797, 17)
Show SMILES CSCCNC(C)(C)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C25H33N5OS/c1-24(2)10-8-17(9-11-24)20-14-18(25(3,4)28-12-13-32-5)6-7-21(20)30-23(31)22-27-16-19(15-26)29-22/h6-8,14,16,28H,9-13H2,1-5H3,(H,27,29)(H,30,31)
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n/an/a 1.40n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198855
PNG
(US9221797, 18)
Show SMILES CC(C)(NCCS(C)(=O)=O)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C25H33N5O3S/c1-24(2)10-8-17(9-11-24)20-14-18(25(3,4)28-12-13-34(5,32)33)6-7-21(20)30-23(31)22-27-16-19(15-26)29-22/h6-8,14,16,28H,9-13H2,1-5H3,(H,27,29)(H,30,31)
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n/an/a 1.80n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198856
PNG
(US9221797, 19)
Show SMILES CN(CCS(C)(=O)=O)C(C)(C)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C26H35N5O3S/c1-25(2)11-9-18(10-12-25)21-15-19(26(3,4)31(5)13-14-35(6,33)34)7-8-22(21)30-24(32)23-28-17-20(16-27)29-23/h7-9,15,17H,10-14H2,1-6H3,(H,28,29)(H,30,32)
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n/an/a 7.20n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198857
PNG
(BDBM198884 | US9221797, 20)
Show SMILES COCCNC(C)(C)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C25H33N5O2/c1-24(2)10-8-17(9-11-24)20-14-18(25(3,4)28-12-13-32-5)6-7-21(20)30-23(31)22-27-16-19(15-26)29-22/h6-8,14,16,28H,9-13H2,1-5H3,(H,27,29)(H,30,31)
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n/an/a 0.440n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198858
PNG
(US9221797, 21)
Show SMILES COCCN(C)C(C)(C)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C26H35N5O2/c1-25(2)11-9-18(10-12-25)21-15-19(26(3,4)31(5)13-14-33-6)7-8-22(21)30-24(32)23-28-17-20(16-27)29-23/h7-9,15,17H,10-14H2,1-6H3,(H,28,29)(H,30,32)
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US Patent
n/an/a 2.60n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198858
PNG
(US9221797, 21)
Show SMILES COCCN(C)C(C)(C)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C26H35N5O2/c1-25(2)11-9-18(10-12-25)21-15-19(26(3,4)31(5)13-14-33-6)7-8-22(21)30-24(32)23-28-17-20(16-27)29-23/h7-9,15,17H,10-14H2,1-6H3,(H,28,29)(H,30,32)
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n/an/a 1.70n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198859
PNG
(US9221797, 22)
Show SMILES CC(C)(N1CCOCC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C26H33N5O2/c1-25(2)9-7-18(8-10-25)21-15-19(26(3,4)31-11-13-33-14-12-31)5-6-22(21)30-24(32)23-28-17-20(16-27)29-23/h5-7,15,17H,8-14H2,1-4H3,(H,28,29)(H,30,32)
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n/an/a 0.940n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198860
PNG
(US9221797, 23)
Show SMILES CN1CCN(CC1)C(C)(C)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C27H36N6O/c1-26(2)10-8-19(9-11-26)22-16-20(27(3,4)33-14-12-32(5)13-15-33)6-7-23(22)31-25(34)24-29-18-21(17-28)30-24/h6-8,16,18H,9-15H2,1-5H3,(H,29,30)(H,31,34)
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n/an/a 2.90n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198860
PNG
(US9221797, 23)
Show SMILES CN1CCN(CC1)C(C)(C)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C27H36N6O/c1-26(2)10-8-19(9-11-26)22-16-20(27(3,4)33-14-12-32(5)13-15-33)6-7-23(22)31-25(34)24-29-18-21(17-28)30-24/h6-8,16,18H,9-15H2,1-5H3,(H,29,30)(H,31,34)
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n/an/a 5.10n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198861
PNG
(US9221797, 24)
Show SMILES CC(C)(NCCN1CCOCC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C28H38N6O2/c1-27(2)9-7-20(8-10-27)23-17-21(28(3,4)31-11-12-34-13-15-36-16-14-34)5-6-24(23)33-26(35)25-30-19-22(18-29)32-25/h5-7,17,19,31H,8-16H2,1-4H3,(H,30,32)(H,33,35)
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n/an/a 1.20n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198862
PNG
(US9221797, 25)
Show SMILES C[C@H]1CN(C[C@@H](C)N1)S(=O)(=O)Cc1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C24H30N6O3S/c1-16-13-30(14-17(2)27-16)34(32,33)15-18-8-9-22(21(10-18)19-6-4-3-5-7-19)29-24(31)23-26-12-20(11-25)28-23/h6,8-10,12,16-17,27H,3-5,7,13-15H2,1-2H3,(H,26,28)(H,29,31)/t16-,17+
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n/an/a 7.74n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198863
PNG
(US9221797, 26)
Show SMILES O=C(Nc1ccc(CCS(=O)(=O)N2CCOCC2)cc1C1=CCCCC1)c1nc(c[nH]1)C#N
Show InChI InChI=1S/C23H27N5O4S/c24-15-19-16-25-22(26-19)23(29)27-21-7-6-17(14-20(21)18-4-2-1-3-5-18)8-13-33(30,31)28-9-11-32-12-10-28/h4,6-7,14,16H,1-3,5,8-13H2,(H,25,26)(H,27,29)
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n/an/a 3.20n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198863
PNG
(US9221797, 26)
Show SMILES O=C(Nc1ccc(CCS(=O)(=O)N2CCOCC2)cc1C1=CCCCC1)c1nc(c[nH]1)C#N
Show InChI InChI=1S/C23H27N5O4S/c24-15-19-16-25-22(26-19)23(29)27-21-7-6-17(14-20(21)18-4-2-1-3-5-18)8-13-33(30,31)28-9-11-32-12-10-28/h4,6-7,14,16H,1-3,5,8-13H2,(H,25,26)(H,27,29)
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n/an/a 3.70n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198863
PNG
(US9221797, 26)
Show SMILES O=C(Nc1ccc(CCS(=O)(=O)N2CCOCC2)cc1C1=CCCCC1)c1nc(c[nH]1)C#N
Show InChI InChI=1S/C23H27N5O4S/c24-15-19-16-25-22(26-19)23(29)27-21-7-6-17(14-20(21)18-4-2-1-3-5-18)8-13-33(30,31)28-9-11-32-12-10-28/h4,6-7,14,16H,1-3,5,8-13H2,(H,25,26)(H,27,29)
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n/an/a 3.60n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198864
PNG
(US9221797, 27)
Show SMILES CC1(C)CCC(=CC1)c1cc(CCS(=O)(=O)N2CCOCC2)ccc1NC(=O)c1nc(c[nH]1)C#N
Show InChI InChI=1S/C25H31N5O4S/c1-25(2)8-5-19(6-9-25)21-15-18(7-14-35(32,33)30-10-12-34-13-11-30)3-4-22(21)29-24(31)23-27-17-20(16-26)28-23/h3-5,15,17H,6-14H2,1-2H3,(H,27,28)(H,29,31)
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n/an/a 4.5n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198865
PNG
(US9221797, 28)
Show SMILES CN(C)S(=O)(=O)CCc1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C21H25N5O3S/c1-26(2)30(28,29)11-10-15-8-9-19(18(12-15)16-6-4-3-5-7-16)25-21(27)20-23-14-17(13-22)24-20/h6,8-9,12,14H,3-5,7,10-11H2,1-2H3,(H,23,24)(H,25,27)
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n/an/a 9.40n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198866
PNG
(US9221797, 29)
Show SMILES CN(C)S(=O)(=O)CCc1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C23H29N5O3S/c1-23(2)10-7-17(8-11-23)19-13-16(9-12-32(30,31)28(3)4)5-6-20(19)27-22(29)21-25-15-18(14-24)26-21/h5-7,13,15H,8-12H2,1-4H3,(H,25,26)(H,27,29)
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n/an/a 2.90n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198867
PNG
(US9221797, 30)
Show SMILES CNS(=O)(=O)CCc1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C20H23N5O3S/c1-22-29(27,28)10-9-14-7-8-18(17(11-14)15-5-3-2-4-6-15)25-20(26)19-23-13-16(12-21)24-19/h5,7-8,11,13,22H,2-4,6,9-10H2,1H3,(H,23,24)(H,25,26)
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n/an/a 5.60n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198868
PNG
(US9221797, 31)
Show SMILES CNS(=O)(=O)CCc1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C22H27N5O3S/c1-22(2)9-6-16(7-10-22)18-12-15(8-11-31(29,30)24-3)4-5-19(18)27-21(28)20-25-14-17(13-23)26-20/h4-6,12,14,24H,7-11H2,1-3H3,(H,25,26)(H,27,28)
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n/an/a 2.60n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198869
PNG
(US9221797, 32)
Show SMILES O=C(Nc1ccc(CS(=O)(=O)N2CCOCC2)cc1C1=CCCCC1)c1nc(c[nH]1)C#N
Show InChI InChI=1S/C22H25N5O4S/c23-13-18-14-24-21(25-18)22(28)26-20-7-6-16(12-19(20)17-4-2-1-3-5-17)15-32(29,30)27-8-10-31-11-9-27/h4,6-7,12,14H,1-3,5,8-11,15H2,(H,24,25)(H,26,28)
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n/an/a 12.8n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198870
PNG
(US9221797, 33)
Show SMILES Cc1nc([nH]c1C#N)C(=O)Nc1ccc(CCN2CCOCC2)cc1C1=CCCCC1
Show InChI InChI=1S/C24H29N5O2/c1-17-22(16-25)27-23(26-17)24(30)28-21-8-7-18(9-10-29-11-13-31-14-12-29)15-20(21)19-5-3-2-4-6-19/h5,7-8,15H,2-4,6,9-14H2,1H3,(H,26,27)(H,28,30)
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n/an/a>60n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM119022
PNG
(US8674100, 34 | US9221797, 34)
Show SMILES CSc1ncc([nH]1)C(=O)Nc1ccc(CCN2CCOCC2)cc1C1=CCCCC1
Show InChI InChI=1S/C23H30N4O2S/c1-30-23-24-16-21(26-23)22(28)25-20-8-7-17(9-10-27-11-13-29-14-12-27)15-19(20)18-5-3-2-4-6-18/h5,7-8,15-16H,2-4,6,9-14H2,1H3,(H,24,26)(H,25,28)
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n/an/a 373n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM119023
PNG
(US8674100, 35 | US9221797, 35)
Show SMILES CS(=O)c1ncc([nH]1)C(=O)Nc1ccc(CCN2CCOCC2)cc1C1=CCCCC1
Show InChI InChI=1S/C23H30N4O3S/c1-31(29)23-24-16-21(26-23)22(28)25-20-8-7-17(9-10-27-11-13-30-14-12-27)15-19(20)18-5-3-2-4-6-18/h5,7-8,15-16H,2-4,6,9-14H2,1H3,(H,24,26)(H,25,28)
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n/an/a>500n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM119024
PNG
(US8674100, 36 | US9221797, 36)
Show SMILES CS(=O)(=O)c1ncc([nH]1)C(=O)Nc1ccc(CCN2CCOCC2)cc1C1=CCCCC1
Show InChI InChI=1S/C23H30N4O4S/c1-32(29,30)23-24-16-21(26-23)22(28)25-20-8-7-17(9-10-27-11-13-31-14-12-27)15-19(20)18-5-3-2-4-6-18/h5,7-8,15-16H,2-4,6,9-14H2,1H3,(H,24,26)(H,25,28)
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Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198871
PNG
(US9221797, 37)
Show SMILES Cc1c[nH]c(n1)C(=O)Nc1ccc(CCN2CCOCC2)cc1C1=CCCCC1
Show InChI InChI=1S/C23H30N4O2/c1-17-16-24-22(25-17)23(28)26-21-8-7-18(9-10-27-11-13-29-14-12-27)15-20(21)19-5-3-2-4-6-19/h5,7-8,15-16H,2-4,6,9-14H2,1H3,(H,24,25)(H,26,28)
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n/an/a 300n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM119026
PNG
(US8674100, 38 | US9221797, 38)
Show SMILES Clc1nc([nH]c1Cl)C(=O)Nc1ccc(CCN2CCOCC2)cc1C1=CCCCC1
Show InChI InChI=1S/C22H26Cl2N4O2/c23-19-20(24)27-21(26-19)22(29)25-18-7-6-15(8-9-28-10-12-30-13-11-28)14-17(18)16-4-2-1-3-5-16/h4,6-7,14H,1-3,5,8-13H2,(H,25,29)(H,26,27)
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n/an/a>60n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM119027
PNG
(US8674100, 39 | US9221797, 39)
Show SMILES O=C(Nc1ccc(CCN2CCOCC2)cc1C1=CCCCC1)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C26H30N4O2/c31-26(25-27-23-8-4-5-9-24(23)28-25)29-22-11-10-19(12-13-30-14-16-32-17-15-30)18-21(22)20-6-2-1-3-7-20/h4-6,8-11,18H,1-3,7,12-17H2,(H,27,28)(H,29,31)
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US Patent
n/an/a>60n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM119028
PNG
(US8674100, 40 | US9221797, 40)
Show SMILES Brc1cnc([nH]1)C(=O)Nc1ccc(CCN2CCOCC2)cc1C1=CCCCC1
Show InChI InChI=1S/C22H27BrN4O2/c23-20-15-24-21(26-20)22(28)25-19-7-6-16(8-9-27-10-12-29-13-11-27)14-18(19)17-4-2-1-3-5-17/h4,6-7,14-15H,1-3,5,8-13H2,(H,24,26)(H,25,28)
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n/an/a 27.9n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198872
PNG
(US9221797, 41)
Show SMILES Clc1cnc([nH]1)C(=O)Nc1ccc(CCN2CCOCC2)cc1C1=CCCCC1
Show InChI InChI=1S/C22H27ClN4O2/c23-20-15-24-21(26-20)22(28)25-19-7-6-16(8-9-27-10-12-29-13-11-27)14-18(19)17-4-2-1-3-5-17/h4,6-7,14-15H,1-3,5,8-13H2,(H,24,26)(H,25,28)
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US Patent
n/an/a 8.20n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM50443132
PNG
(CHEMBL3086175 | US9221797, 42)
Show SMILES O=C(Nc1ccc(CCN2CCOCC2)cc1C1=CCCCC1)c1ncc([nH]1)C#N
Show InChI InChI=1S/C23H27N5O2/c24-15-19-16-25-22(26-19)23(29)27-21-7-6-17(8-9-28-10-12-30-13-11-28)14-20(21)18-4-2-1-3-5-18/h4,6-7,14,16H,1-3,5,8-13H2,(H,25,26)(H,27,29)
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n/an/a 1.43n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM50443141
PNG
(CHEMBL3085983 | US9221797, 44)
Show SMILES O=C(Nc1ccc(CN2CCOCC2)cc1C1=CCCCC1)c1ncc([nH]1)C#N
Show InChI InChI=1S/C22H25N5O2/c23-13-18-14-24-21(25-18)22(28)26-20-7-6-16(15-27-8-10-29-11-9-27)12-19(20)17-4-2-1-3-5-17/h4,6-7,12,14H,1-3,5,8-11,15H2,(H,24,25)(H,26,28)
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n/an/a 4.60n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198873
PNG
(US9221797, 45)
Show SMILES CC1CCCC(=C1C)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)C(C)(C)N1CCCC1
Show InChI InChI=1S/C26H33N5O/c1-17-8-7-9-21(18(17)2)22-14-19(26(3,4)31-12-5-6-13-31)10-11-23(22)30-25(32)24-28-16-20(15-27)29-24/h10-11,14,16-17H,5-9,12-13H2,1-4H3,(H,28,29)(H,30,32)
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n/an/a 0.600n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM119033
PNG
(US8674100, 46 | US9221797, 46)
Show SMILES CC1(C)CCC(=CC1)c1cc(ccc1NC(=O)c1ncc([nH]1)C#N)C(O)C(O)=O
Show InChI InChI=1S/C21H22N4O4/c1-21(2)7-5-12(6-8-21)15-9-13(17(26)20(28)29)3-4-16(15)25-19(27)18-23-11-14(10-22)24-18/h3-5,9,11,17,26H,6-8H2,1-2H3,(H,23,24)(H,25,27)(H,28,29)
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n/an/a 2.5n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (CSF1R) or (c-fms)


(Homo sapiens (Human))
BDBM198874
PNG
(US9221797, 47)
Show SMILES COC[C@H](O)Cc1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
Show InChI InChI=1S/C23H28N4O3/c1-23(2)8-6-16(7-9-23)19-11-15(10-18(28)14-30-3)4-5-20(19)27-22(29)21-25-13-17(12-24)26-21/h4-6,11,13,18,28H,7-10,14H2,1-3H3,(H,25,26)(H,27,29)/t18-/m1/s1
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US Patent
n/an/a 1.5n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...


US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair
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