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Found 1532 hits Enz. Inhib. hit(s) with Target = 'Macrophage colony-stimulating factor 1 receptor (c-Fms)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM132043
PNG
(US8841455, 138)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(CCCN5CCN(C)CC5)ccn34)c12
Show InChI InChI=1S/C32H38N8O/c1-4-26-31-27(11-6-12-28(31)40(36-26)22-25-10-5-8-23(2)34-25)35-32(41)29-21-33-30-20-24(13-15-39(29)30)9-7-14-38-18-16-37(3)17-19-38/h5-6,8,10-13,15,20-21H,4,7,9,14,16-19,22H2,1-3H3,(H,35,41)
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n/an/a 275n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM132044
PNG
(US8841455, 139)
Show SMILES COCCOc1ccn2c(cnc2c1)C(=O)Nc1cccc2n(Cc3ccc(C)nc3)nc(OC)c12
Show InChI InChI=1S/C26H26N6O4/c1-17-7-8-18(14-27-17)16-32-21-6-4-5-20(24(21)26(30-32)35-3)29-25(33)22-15-28-23-13-19(9-10-31(22)23)36-12-11-34-2/h4-10,13-15H,11-12,16H2,1-3H3,(H,29,33)
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n/an/a 138n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM132045
PNG
(US8841455, 140)
Show SMILES COCCOc1ccn2c(cnc2c1)C(=O)Nc1cccc2n(Cc3ccc(C)nc3)nc(Br)c12
Show InChI InChI=1S/C25H23BrN6O3/c1-16-6-7-17(13-27-16)15-32-20-5-3-4-19(23(20)24(26)30-32)29-25(33)21-14-28-22-12-18(8-9-31(21)22)35-11-10-34-2/h3-9,12-14H,10-11,15H2,1-2H3,(H,29,33)
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n/an/a 108n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM132046
PNG
(US8841455, 141)
Show SMILES COc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(OCCN5CCN(C)CC5)ccn34)c12
Show InChI InChI=1S/C30H34N8O3/c1-21-6-4-7-22(32-21)20-38-25-9-5-8-24(28(25)30(34-38)40-3)33-29(39)26-19-31-27-18-23(10-11-37(26)27)41-17-16-36-14-12-35(2)13-15-36/h4-11,18-19H,12-17,20H2,1-3H3,(H,33,39)
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n/an/a 32.7n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM132047
PNG
(US8841455, 142)
Show SMILES CCc1nn(Cc2nccs2)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C21H18N6OS/c1-2-14-20-15(24-21(28)17-12-23-18-8-3-4-10-26(17)18)6-5-7-16(20)27(25-14)13-19-22-9-11-29-19/h3-12H,2,13H2,1H3,(H,24,28)
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n/an/a 1.56E+3n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM132048
PNG
(US8841455, 143)
Show SMILES CCc1nn(Cc2ccc(C)nc2)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C24H22N6O/c1-3-18-23-19(27-24(31)21-14-26-22-9-4-5-12-29(21)22)7-6-8-20(23)30(28-18)15-17-11-10-16(2)25-13-17/h4-14H,3,15H2,1-2H3,(H,27,31)
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n/an/a 711n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM132049
PNG
(US8841455, 144)
Show SMILES CCc1nn(Cc2ccc(C)nc2)c2cccc(NC(=O)c3cnc4cc(OCCN5CCN(C)CC5)ccn34)c12
Show InChI InChI=1S/C31H36N8O2/c1-4-25-30-26(6-5-7-27(30)39(35-25)21-23-9-8-22(2)32-19-23)34-31(40)28-20-33-29-18-24(10-11-38(28)29)41-17-16-37-14-12-36(3)13-15-37/h5-11,18-20H,4,12-17,21H2,1-3H3,(H,34,40)
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n/an/a 276n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM132050
PNG
(US8841455, 145)
Show SMILES CCc1nn(Cc2nccs2)c2cccc(NC(=O)c3cnc4cc(OCCN5CCN(C)CC5)ccn34)c12
Show InChI InChI=1S/C28H32N8O2S/c1-3-21-27-22(5-4-6-23(27)36(32-21)19-26-29-8-16-39-26)31-28(37)24-18-30-25-17-20(7-9-35(24)25)38-15-14-34-12-10-33(2)11-13-34/h4-9,16-18H,3,10-15,19H2,1-2H3,(H,31,37)
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n/an/a 179n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM132051
PNG
(US8841455, 146)
Show SMILES CCc1nn(Cc2nc(C)cs2)c2cccc(NC(=O)c3cnc4cc(OCCN5CCN(C)CC5)ccn34)c12
Show InChI InChI=1S/C29H34N8O2S/c1-4-22-28-23(6-5-7-24(28)37(33-22)18-27-31-20(2)19-40-27)32-29(38)25-17-30-26-16-21(8-9-36(25)26)39-15-14-35-12-10-34(3)11-13-35/h5-9,16-17,19H,4,10-15,18H2,1-3H3,(H,32,38)
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n/an/a 102n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM132052
PNG
(US8841455, 147)
Show SMILES CN1CCN(CCOc2ccn3c(cnc3c2)C(=O)Nc2cccc3n(Cc4ccc(C)nc4)nc(C4CC4)c23)CC1
Show InChI InChI=1S/C32H36N8O2/c1-22-6-7-23(19-33-22)21-40-27-5-3-4-26(30(27)31(36-40)24-8-9-24)35-32(41)28-20-34-29-18-25(10-11-39(28)29)42-17-16-38-14-12-37(2)13-15-38/h3-7,10-11,18-20,24H,8-9,12-17,21H2,1-2H3,(H,35,41)
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n/an/a 123n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM132053
PNG
(US8841455, 148)
Show SMILES CCc1nn(Cc2csc(C)n2)c2cccc(NC(=O)c3cnc4cc(OCCN5CCN(C)CC5)ccn34)c12
Show InChI InChI=1S/C29H34N8O2S/c1-4-23-28-24(6-5-7-25(28)37(33-23)18-21-19-40-20(2)31-21)32-29(38)26-17-30-27-16-22(8-9-36(26)27)39-15-14-35-12-10-34(3)11-13-35/h5-9,16-17,19H,4,10-15,18H2,1-3H3,(H,32,38)
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n/an/a 260n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM132054
PNG
(US8841455, 149)
Show SMILES CCc1nn(Cc2ccc(F)cn2)c2cccc(NC(=O)c3cnc4cc(OCCN5CCN(C)CC5)ccn34)c12
Show InChI InChI=1S/C30H33FN8O2/c1-3-24-29-25(5-4-6-26(29)39(35-24)20-22-8-7-21(31)18-32-22)34-30(40)27-19-33-28-17-23(9-10-38(27)28)41-16-15-37-13-11-36(2)12-14-37/h4-10,17-19H,3,11-16,20H2,1-2H3,(H,34,40)
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n/an/a 201n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM132055
PNG
(US8841455, 150)
Show SMILES CN1CCN(CCOc2ccn3c(cnc3c2)C(=O)Nc2cccc3n(Cc4ccc(F)cn4)nc(C4CC4)c23)CC1
Show InChI InChI=1S/C31H33FN8O2/c1-37-11-13-38(14-12-37)15-16-42-24-9-10-39-27(19-34-28(39)17-24)31(41)35-25-3-2-4-26-29(25)30(21-5-6-21)36-40(26)20-23-8-7-22(32)18-33-23/h2-4,7-10,17-19,21H,5-6,11-16,20H2,1H3,(H,35,41)
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n/an/a 136n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM132056
PNG
(US8841455, 151)
Show SMILES CN1CCN(CCOc2ccn3c(cnc3c2)C(=O)Nc2cccc3n(Cc4csc(C)n4)nc(C4CC4)c23)CC1
Show InChI InChI=1S/C30H34N8O2S/c1-20-32-22(19-41-20)18-38-25-5-3-4-24(28(25)29(34-38)21-6-7-21)33-30(39)26-17-31-27-16-23(8-9-37(26)27)40-15-14-36-12-10-35(2)11-13-36/h3-5,8-9,16-17,19,21H,6-7,10-15,18H2,1-2H3,(H,33,39)
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n/an/a 149n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM132057
PNG
(US8841455, 152)
Show SMILES CCc1nn(Cc2csc(n2)C(C)C)c2cccc(NC(=O)c3cnc4cc(OCCN5CCN(C)CC5)ccn34)c12
Show InChI InChI=1S/C31H38N8O2S/c1-5-24-29-25(7-6-8-26(29)39(35-24)19-22-20-42-31(33-22)21(2)3)34-30(40)27-18-32-28-17-23(9-10-38(27)28)41-16-15-37-13-11-36(4)12-14-37/h6-10,17-18,20-21H,5,11-16,19H2,1-4H3,(H,34,40)
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n/an/a 79.5n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM132058
PNG
(US8841455, 153)
Show SMILES CC(C)c1nc(Cn2nc(C3CC3)c3c(NC(=O)c4cnc5cc(OCCN6CCN(C)CC6)ccn45)cccc23)cs1
Show InChI InChI=1S/C32H38N8O2S/c1-21(2)32-34-23(20-43-32)19-40-26-6-4-5-25(29(26)30(36-40)22-7-8-22)35-31(41)27-18-33-28-17-24(9-10-39(27)28)42-16-15-38-13-11-37(3)12-14-38/h4-6,9-10,17-18,20-22H,7-8,11-16,19H2,1-3H3,(H,35,41)
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n/an/a 118n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM132059
PNG
(US8841455, 154)
Show SMILES CC(C)N1CCN(CCOc2ccn3c(cnc3c2)C(=O)Nc2cccc3n(Cc4ccc(F)cn4)nc(C4CC4)c23)CC1
Show InChI InChI=1S/C33H37FN8O2/c1-22(2)40-14-12-39(13-15-40)16-17-44-26-10-11-41-29(20-36-30(41)18-26)33(43)37-27-4-3-5-28-31(27)32(23-6-7-23)38-42(28)21-25-9-8-24(34)19-35-25/h3-5,8-11,18-20,22-23H,6-7,12-17,21H2,1-2H3,(H,37,43)
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n/an/a 132n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM132060
PNG
(US8841455, 155)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(SCCNC(C)=O)ccn34)c12
Show InChI InChI=1S/C28H29N7O2S/c1-4-22-27-23(9-6-10-24(27)35(33-22)17-20-8-5-7-18(2)31-20)32-28(37)25-16-30-26-15-21(11-13-34(25)26)38-14-12-29-19(3)36/h5-11,13,15-16H,4,12,14,17H2,1-3H3,(H,29,36)(H,32,37)
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n/an/a 218n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM132061
PNG
(US8841455, 156)
Show SMILES CN1CCN(CCOc2ccn3c(cnc3c2)C(=O)Nc2cccc3n(Cc4ccc(O)c(C)n4)nc(C4CC4)c23)CC1
Show InChI InChI=1S/C32H36N8O3/c1-21-28(41)9-8-23(34-21)20-40-26-5-3-4-25(30(26)31(36-40)22-6-7-22)35-32(42)27-19-33-29-18-24(10-11-39(27)29)43-17-16-38-14-12-37(2)13-15-38/h3-5,8-11,18-19,22,41H,6-7,12-17,20H2,1-2H3,(H,35,42)
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n/an/a 86.8n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM132062
PNG
(US8841455, 157)
Show SMILES Cc1cccc(Cn2nc(C3CC3)c3c(NC(=O)c4cnc5cc(OCc6ccccc6)ccn45)cccc23)n1
Show InChI InChI=1S/C32H28N6O2/c1-21-7-5-10-24(34-21)19-38-27-12-6-11-26(30(27)31(36-38)23-13-14-23)35-32(39)28-18-33-29-17-25(15-16-37(28)29)40-20-22-8-3-2-4-9-22/h2-12,15-18,23H,13-14,19-20H2,1H3,(H,35,39)
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n/an/a 494n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM132063
PNG
(US8841455, 158)
Show SMILES Cc1cccc(Cn2nc(C3CC3)c3c(NC(=O)c4cnc5cc(O)ccn45)cccc23)n1
Show InChI InChI=1S/C25H22N6O2/c1-15-4-2-5-17(27-15)14-31-20-7-3-6-19(23(20)24(29-31)16-8-9-16)28-25(33)21-13-26-22-12-18(32)10-11-30(21)22/h2-7,10-13,16,32H,8-9,14H2,1H3,(H,28,33)
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n/an/a 227n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM132064
PNG
(US8841455, 159)
Show SMILES CSc1ccn2c(cnc2c1)C(=O)Nc1cccc2n(Cc3cccc(C)n3)nc(C3CC3)c12
Show InChI InChI=1S/C26H24N6OS/c1-16-5-3-6-18(28-16)15-32-21-8-4-7-20(24(21)25(30-32)17-9-10-17)29-26(33)22-14-27-23-13-19(34-2)11-12-31(22)23/h3-8,11-14,17H,9-10,15H2,1-2H3,(H,29,33)
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n/an/a 18.5n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM132065
PNG
(US8841455, 160)
Show SMILES Cc1cccc(Cn2nc(C3CC3)c3c(NC(=O)c4cnc5cc(OCCOCCOC=C)ccn45)cccc23)n1
Show InChI InChI=1S/C31H32N6O4/c1-3-39-14-15-40-16-17-41-24-12-13-36-27(19-32-28(36)18-24)31(38)34-25-8-5-9-26-29(25)30(22-10-11-22)35-37(26)20-23-7-4-6-21(2)33-23/h3-9,12-13,18-19,22H,1,10-11,14-17,20H2,2H3,(H,34,38)
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n/an/a 90.4n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM132066
PNG
(US8841455, 161)
Show SMILES Cc1cccc(Cn2nc(C3CC3)c3c(NC(=O)c4cnc5cc(OCCOCCO)ccn45)cccc23)n1
Show InChI InChI=1S/C29H30N6O4/c1-19-4-2-5-21(31-19)18-35-24-7-3-6-23(27(24)28(33-35)20-8-9-20)32-29(37)25-17-30-26-16-22(10-11-34(25)26)39-15-14-38-13-12-36/h2-7,10-11,16-17,20,36H,8-9,12-15,18H2,1H3,(H,32,37)
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n/an/a 753n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM132067
PNG
(US8841455, 162)
Show SMILES Cc1cccc(Cn2nc(C3CC3)c3c(NC(=O)c4cnc5cc(Br)ccn45)cccc23)n1
Show InChI InChI=1S/C25H21BrN6O/c1-15-4-2-5-18(28-15)14-32-20-7-3-6-19(23(20)24(30-32)16-8-9-16)29-25(33)21-13-27-22-12-17(26)10-11-31(21)22/h2-7,10-13,16H,8-9,14H2,1H3,(H,29,33)
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n/an/a 74.4n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM132068
PNG
(US8841455, 65 Step D)
Show SMILES CN1CCN(CCOc2ccn3c(cnc3c2)C(=O)Nc2cccc3n(Cc4cccc(C)n4)nc(C4CC4)c23)CC1
Show InChI InChI=1S/C32H36N8O2/c1-22-5-3-6-24(34-22)21-40-27-8-4-7-26(30(27)31(36-40)23-9-10-23)35-32(41)28-20-33-29-19-25(11-12-39(28)29)42-18-17-38-15-13-37(2)14-16-38/h3-8,11-12,19-20,23H,9-10,13-18,21H2,1-2H3,(H,35,41)
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n/an/a 93.6n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM132069
PNG
(US8841455, 77 Step C)
Show SMILES Cc1cccc(Cn2nc(C3CC3)c3c(NC(=O)c4cnc5cc(OCCN6CCC6)ccn45)cccc23)n1
Show InChI InChI=1S/C30H31N7O2/c1-20-5-2-6-22(32-20)19-37-25-8-3-7-24(28(25)29(34-37)21-9-10-21)33-30(38)26-18-31-27-17-23(11-14-36(26)27)39-16-15-35-12-4-13-35/h2-3,5-8,11,14,17-18,21H,4,9-10,12-13,15-16,19H2,1H3,(H,33,38)
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n/an/a 150n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM132070
PNG
(US8841455, 117 Step B)
Show SMILES CCc1nn(Cc2ccn(CC)n2)c2cccc(NC(=O)c3cnc4cc(ccn34)-n3cncn3)c12
Show InChI InChI=1S/C25H24N10O/c1-3-19-24-20(6-5-7-21(24)34(31-19)14-17-8-10-32(4-2)30-17)29-25(36)22-13-27-23-12-18(9-11-33(22)23)35-16-26-15-28-35/h5-13,15-16H,3-4,14H2,1-2H3,(H,29,36)
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n/an/a 463n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131979
PNG
(US8841455, 74)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(OCCN5CCN(CC5)C(C)C)ccn34)c12
Show InChI InChI=1S/C33H40N8O2/c1-5-27-32-28(10-7-11-29(32)41(37-27)22-25-9-6-8-24(4)35-25)36-33(42)30-21-34-31-20-26(12-13-40(30)31)43-19-18-38-14-16-39(17-15-38)23(2)3/h6-13,20-21,23H,5,14-19,22H2,1-4H3,(H,36,42)
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n/an/a 158n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131980
PNG
(US8841455, 75)
Show SMILES CC(C)N1CCN(CCOc2ccn3c(cnc3c2)C(=O)Nc2cccc3n(Cc4cccc(C)n4)nc(C4CC4)c23)CC1
Show InChI InChI=1S/C34H40N8O2/c1-23(2)40-16-14-39(15-17-40)18-19-44-27-12-13-41-30(21-35-31(41)20-27)34(43)37-28-8-5-9-29-32(28)33(25-10-11-25)38-42(29)22-26-7-4-6-24(3)36-26/h4-9,12-13,20-21,23,25H,10-11,14-19,22H2,1-3H3,(H,37,43)
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n/an/a 107n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131981
PNG
(US8841455, 76)
Show SMILES CN1CCN(CCOc2ccn3c(cnc3c2)C(=O)Nc2cccc3n(Cc4cccn(C)c4=O)nc(C4CC4)c23)CC1
Show InChI InChI=1S/C32H36N8O3/c1-36-13-15-38(16-14-36)17-18-43-24-10-12-39-27(20-33-28(39)19-24)31(41)34-25-6-3-7-26-29(25)30(22-8-9-22)35-40(26)21-23-5-4-11-37(2)32(23)42/h3-7,10-12,19-20,22H,8-9,13-18,21H2,1-2H3,(H,34,41)
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n/an/a 267n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131982
PNG
(US8841455, 77 Step B)
Show SMILES Cc1cccc(Cn2nc(C3CC3)c3c(NC(=O)c4cnc5cc(F)ccn45)cccc23)n1
Show InChI InChI=1S/C25H21FN6O/c1-15-4-2-5-18(28-15)14-32-20-7-3-6-19(23(20)24(30-32)16-8-9-16)29-25(33)21-13-27-22-12-17(26)10-11-31(21)22/h2-7,10-13,16H,8-9,14H2,1H3,(H,29,33)
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n/an/a 497n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131983
PNG
(US8841455, 78)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(OCC5CCN(C)CC5)ccn34)c12
Show InChI InChI=1S/C31H35N7O2/c1-4-25-30-26(9-6-10-27(30)38(35-25)19-23-8-5-7-21(2)33-23)34-31(39)28-18-32-29-17-24(13-16-37(28)29)40-20-22-11-14-36(3)15-12-22/h5-10,13,16-18,22H,4,11-12,14-15,19-20H2,1-3H3,(H,34,39)
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n/an/a 82.5n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131984
PNG
(US8841455, 79)
Show SMILES CCN1CCN(CCOc2ccn3c(cnc3c2)C(=O)Nc2cccc3n(Cc4cccc(C)n4)nc(CC)c23)CC1
Show InChI InChI=1S/C32H38N8O2/c1-4-26-31-27(10-7-11-28(31)40(36-26)22-24-9-6-8-23(3)34-24)35-32(41)29-21-33-30-20-25(12-13-39(29)30)42-19-18-38-16-14-37(5-2)15-17-38/h6-13,20-21H,4-5,14-19,22H2,1-3H3,(H,35,41)
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n/an/a 120n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131985
PNG
(US8841455, 80)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(O[C@@H]5CCN(C)C5)ccn34)c12
Show InChI InChI=1S/C29H31N7O2/c1-4-23-28-24(9-6-10-25(28)36(33-23)17-20-8-5-7-19(2)31-20)32-29(37)26-16-30-27-15-21(12-14-35(26)27)38-22-11-13-34(3)18-22/h5-10,12,14-16,22H,4,11,13,17-18H2,1-3H3,(H,32,37)/t22-/m1/s1
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n/an/a 185n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131986
PNG
(US8841455, 81)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(OC5CCN(C)CC5)ccn34)c12
Show InChI InChI=1S/C30H33N7O2/c1-4-24-29-25(9-6-10-26(29)37(34-24)19-21-8-5-7-20(2)32-21)33-30(38)27-18-31-28-17-23(13-16-36(27)28)39-22-11-14-35(3)15-12-22/h5-10,13,16-18,22H,4,11-12,14-15,19H2,1-3H3,(H,33,38)
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n/an/a 164n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131987
PNG
(US8841455, 82)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(OCCN5CCCC5)ccn34)c12
Show InChI InChI=1S/C30H33N7O2/c1-3-24-29-25(10-7-11-26(29)37(34-24)20-22-9-6-8-21(2)32-22)33-30(38)27-19-31-28-18-23(12-15-36(27)28)39-17-16-35-13-4-5-14-35/h6-12,15,18-19H,3-5,13-14,16-17,20H2,1-2H3,(H,33,38)
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n/an/a 173n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131988
PNG
(US8841455, 83)
Show SMILES Cc1cccc(Cn2nc(C3CC3)c3c(NC(=O)c4cnc5cc(OCCN6CCOCC6)ccn45)cccc23)n1
Show InChI InChI=1S/C31H33N7O3/c1-21-4-2-5-23(33-21)20-38-26-7-3-6-25(29(26)30(35-38)22-8-9-22)34-31(39)27-19-32-28-18-24(10-11-37(27)28)41-17-14-36-12-15-40-16-13-36/h2-7,10-11,18-19,22H,8-9,12-17,20H2,1H3,(H,34,39)
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n/an/a 305n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131989
PNG
(US8841455, 84)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(O[C@H]5CCN(C)C5)ccn34)c12
Show InChI InChI=1S/C29H31N7O2/c1-4-23-28-24(9-6-10-25(28)36(33-23)17-20-8-5-7-19(2)31-20)32-29(37)26-16-30-27-15-21(12-14-35(26)27)38-22-11-13-34(3)18-22/h5-10,12,14-16,22H,4,11,13,17-18H2,1-3H3,(H,32,37)/t22-/m0/s1
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n/an/a 188n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131990
PNG
(US8841455, 85)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(OCC5CN(CCO5)C(=O)OC(C)(C)C)ccn34)c12
Show InChI InChI=1S/C34H39N7O5/c1-6-26-31-27(11-8-12-28(31)41(38-26)19-23-10-7-9-22(2)36-23)37-32(42)29-18-35-30-17-24(13-14-40(29)30)45-21-25-20-39(15-16-44-25)33(43)46-34(3,4)5/h7-14,17-18,25H,6,15-16,19-21H2,1-5H3,(H,37,42)
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n/an/a 380n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131991
PNG
(US8841455, 86)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(OCC(F)(F)CNC(=O)OC(C)(C)C)ccn34)c12
Show InChI InChI=1S/C32H35F2N7O4/c1-6-23-28-24(11-8-12-25(28)41(39-23)17-21-10-7-9-20(2)37-21)38-29(42)26-16-35-27-15-22(13-14-40(26)27)44-19-32(33,34)18-36-30(43)45-31(3,4)5/h7-16H,6,17-19H2,1-5H3,(H,36,43)(H,38,42)
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n/an/a 877n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131992
PNG
(US8841455, 87)
Show SMILES CCc1nn(Cc2ccn(CC)n2)c2cccc(NC(=O)c3cnc4cc(OCCN5CCN(CC5)C(C)C)ccn34)c12
Show InChI InChI=1S/C32H41N9O2/c1-5-26-31-27(8-7-9-28(31)41(36-26)22-24-10-12-39(6-2)35-24)34-32(42)29-21-33-30-20-25(11-13-40(29)30)43-19-18-37-14-16-38(17-15-37)23(3)4/h7-13,20-21,23H,5-6,14-19,22H2,1-4H3,(H,34,42)
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n/an/a 168n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131993
PNG
(US8841455, 88)
Show SMILES Cc1cccc(Cn2nc(C3CC3)c3c(NC(=O)c4cnc5cc(OCCN6CCCC6)ccn45)cccc23)n1
Show InChI InChI=1S/C31H33N7O2/c1-21-6-4-7-23(33-21)20-38-26-9-5-8-25(29(26)30(35-38)22-10-11-22)34-31(39)27-19-32-28-18-24(12-15-37(27)28)40-17-16-36-13-2-3-14-36/h4-9,12,15,18-19,22H,2-3,10-11,13-14,16-17,20H2,1H3,(H,34,39)
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n/an/a 141n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131994
PNG
(US8841455, 89)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(OCCN5CC[C@H](C5)OC)ccn34)c12
Show InChI InChI=1S/C31H35N7O3/c1-4-25-30-26(9-6-10-27(30)38(35-25)19-22-8-5-7-21(2)33-22)34-31(39)28-18-32-29-17-23(12-14-37(28)29)41-16-15-36-13-11-24(20-36)40-3/h5-10,12,14,17-18,24H,4,11,13,15-16,19-20H2,1-3H3,(H,34,39)/t24-/m1/s1
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n/an/a 156n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131995
PNG
(US8841455, 90)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(OCCN5CC6CCC(C5)N6C)ccn34)c12
Show InChI InChI=1S/C33H38N8O2/c1-4-27-32-28(9-6-10-29(32)41(37-27)19-23-8-5-7-22(2)35-23)36-33(42)30-18-34-31-17-26(13-14-40(30)31)43-16-15-39-20-24-11-12-25(21-39)38(24)3/h5-10,13-14,17-18,24-25H,4,11-12,15-16,19-21H2,1-3H3,(H,36,42)
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n/an/a 164n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131996
PNG
(US8841455, 91)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(OCCN5CC[C@@H](C5)OC)ccn34)c12
Show InChI InChI=1S/C31H35N7O3/c1-4-25-30-26(9-6-10-27(30)38(35-25)19-22-8-5-7-21(2)33-22)34-31(39)28-18-32-29-17-23(12-14-37(28)29)41-16-15-36-13-11-24(20-36)40-3/h5-10,12,14,17-18,24H,4,11,13,15-16,19-20H2,1-3H3,(H,34,39)/t24-/m0/s1
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n/an/a 183n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131997
PNG
(US8841455, 92)
Show SMILES CCc1nn(Cc2ccn(CC)n2)c2cccc(NC(=O)c3cnc4cc(OCCN5CCCC5)ccn34)c12
Show InChI InChI=1S/C29H34N8O2/c1-3-23-28-24(8-7-9-25(28)37(33-23)20-21-10-14-35(4-2)32-21)31-29(38)26-19-30-27-18-22(11-15-36(26)27)39-17-16-34-12-5-6-13-34/h7-11,14-15,18-19H,3-6,12-13,16-17,20H2,1-2H3,(H,31,38)
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n/an/a 194n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131998
PNG
(US8841455, 93)
Show SMILES CN1CCC(CC1)Oc1ccn2c(cnc2c1)C(=O)Nc1cccc2n(Cc3cccc(C)n3)nc(C3CC3)c12
Show InChI InChI=1S/C31H33N7O2/c1-20-5-3-6-22(33-20)19-38-26-8-4-7-25(29(26)30(35-38)21-9-10-21)34-31(39)27-18-32-28-17-24(13-16-37(27)28)40-23-11-14-36(2)15-12-23/h3-8,13,16-18,21,23H,9-12,14-15,19H2,1-2H3,(H,34,39)
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n/an/a 198n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131999
PNG
(US8841455, 94)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(OCCN5CC[C@H](F)C5)ccn34)c12
Show InChI InChI=1S/C30H32FN7O2/c1-3-24-29-25(8-5-9-26(29)38(35-24)19-22-7-4-6-20(2)33-22)34-30(39)27-17-32-28-16-23(11-13-37(27)28)40-15-14-36-12-10-21(31)18-36/h4-9,11,13,16-17,21H,3,10,12,14-15,18-19H2,1-2H3,(H,34,39)/t21-/m0/s1
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n/an/a 219n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM132000
PNG
(US8841455, 95)
Show SMILES Cc1cccc(Cn2nc(C3CC3)c3c(NC(=O)c4cnc5cc(OCCN6CCS(=O)(=O)CC6)ccn45)cccc23)n1
Show InChI InChI=1S/C31H33N7O4S/c1-21-4-2-5-23(33-21)20-38-26-7-3-6-25(29(26)30(35-38)22-8-9-22)34-31(39)27-19-32-28-18-24(10-11-37(27)28)42-15-12-36-13-16-43(40,41)17-14-36/h2-7,10-11,18-19,22H,8-9,12-17,20H2,1H3,(H,34,39)
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n/an/a 239n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
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