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Compile Data Set for Download or QSAR

Found 195 hits Enz. Inhib. hit(s) with Target = 'Maltase-glucoamylase'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM223316
PNG
(YPYSCWVRH | piHA-Dm)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CS)N1SCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CO)C1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O
Show InChI InChI=1S/C59H76N16O13S2/c1-31(2)49(56(86)68-40(9-5-19-64-59(61)62)51(81)69-41(50(60)80)24-35-26-63-30-66-35)73-53(83)43(23-34-25-65-39-8-4-3-7-38(34)39)71-55(85)47(28-89)75-58(88)45(27-76)72-52(82)42(21-32-11-15-36(77)16-12-32)70-54(84)46-10-6-20-74(46)57(87)44(67-48(79)29-90-75)22-33-13-17-37(78)18-14-33/h3-4,7-8,11-18,25-26,30-31,40-47,49,65,76-78,89H,5-6,9-10,19-24,27-29H2,1-2H3,(H2,60,80)(H,63,66)(H,67,79)(H,68,86)(H,69,81)(H,70,84)(H,71,85)(H,72,82)(H,73,83)(H4,61,62,64)/t40-,41-,42-,43-,44-,45-,46-,47-,49-/m0/s1
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n/an/a 520n/an/an/an/a7.0n/a



The University of Tokyo



Assay Description
After kinetic analysis with HPA, piHA-Dm was tested as an inhibitor of ten additional enzymes. The conditions are listed as follows: Agrobacterium fa...


Cell Chem Biol 24: 381-390 (2017)


Article DOI: 10.1016/j.chembiol.2017.02.001
BindingDB Entry DOI: 10.7270/Q27D2T0M
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Mus musculus (Mouse))
BDBM223316
PNG
(YPYSCWVRH | piHA-Dm)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CS)N1SCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CO)C1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O
Show InChI InChI=1S/C59H76N16O13S2/c1-31(2)49(56(86)68-40(9-5-19-64-59(61)62)51(81)69-41(50(60)80)24-35-26-63-30-66-35)73-53(83)43(23-34-25-65-39-8-4-3-7-38(34)39)71-55(85)47(28-89)75-58(88)45(27-76)72-52(82)42(21-32-11-15-36(77)16-12-32)70-54(84)46-10-6-20-74(46)57(87)44(67-48(79)29-90-75)22-33-13-17-37(78)18-14-33/h3-4,7-8,11-18,25-26,30-31,40-47,49,65,76-78,89H,5-6,9-10,19-24,27-29H2,1-2H3,(H2,60,80)(H,63,66)(H,67,79)(H,68,86)(H,69,81)(H,70,84)(H,71,85)(H,72,82)(H,73,83)(H4,61,62,64)/t40-,41-,42-,43-,44-,45-,46-,47-,49-/m0/s1
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n/an/a 990n/an/an/an/a7.0n/a



The University of Tokyo



Assay Description
After kinetic analysis with HPA, piHA-Dm was tested as an inhibitor of ten additional enzymes. The conditions are listed as follows: Agrobacterium fa...


Cell Chem Biol 24: 381-390 (2017)


Article DOI: 10.1016/j.chembiol.2017.02.001
BindingDB Entry DOI: 10.7270/Q27D2T0M
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50291029
PNG
((2R,3R,4R,5S)-2-Hydroxymethyl-1-((E)-3-trimethylsi...)
Show SMILES C[Si](C)(C)\C=C\CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H25NO4Si/c1-18(2,3)6-4-5-13-7-10(15)12(17)11(16)9(13)8-14/h4,6,9-12,14-17H,5,7-8H2,1-3H3/b6-4+/t9-,10+,11-,12-/m1/s1
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2.30n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition constant against rat small intestinal glucoamylase


Bioorg Med Chem Lett 7: 355-360 (1997)


Article DOI: 10.1016/S0960-894X(97)00012-7
BindingDB Entry DOI: 10.7270/Q2F18ZQ1
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50291026
PNG
((2R,3R,4R,5S)-1-[(E)-3-(Dimethyl-phenyl-silanyl)-a...)
Show SMILES C[Si](C)(\C=C\CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO)c1ccccc1
Show InChI InChI=1S/C17H27NO4Si/c1-23(2,13-7-4-3-5-8-13)10-6-9-18-11-15(20)17(22)16(21)14(18)12-19/h3-8,10,14-17,19-22H,9,11-12H2,1-2H3/b10-6+/t14-,15+,16-,17-/m1/s1
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4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition constant against rat small intestinal glucoamylase


Bioorg Med Chem Lett 7: 355-360 (1997)


Article DOI: 10.1016/S0960-894X(97)00012-7
BindingDB Entry DOI: 10.7270/Q2F18ZQ1
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50291020
PNG
((2R,3R,4R,5S)-1-[3-(Dimethyl-phenyl-silanyl)-propy...)
Show SMILES C[Si](C)(CCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO)c1ccccc1
Show InChI InChI=1S/C17H29NO4Si/c1-23(2,13-7-4-3-5-8-13)10-6-9-18-11-15(20)17(22)16(21)14(18)12-19/h3-5,7-8,14-17,19-22H,6,9-12H2,1-2H3/t14-,15+,16-,17-/m1/s1
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10n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition constant against rat small intestinal glucoamylase


Bioorg Med Chem Lett 7: 355-360 (1997)


Article DOI: 10.1016/S0960-894X(97)00012-7
BindingDB Entry DOI: 10.7270/Q2F18ZQ1
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50327503
PNG
((1R,2R,3S,4S)-3,4-dihydroxy-2-(hydroxymethyl)-1-((...)
Show SMILES OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)C[S@@+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C11H23O8S/c12-1-5(14)10(18)11(19)7(16)4-20-3-6(15)9(17)8(20)2-13/h5-19H,1-4H2/q+1/t5-,6-,7-,8-,9+,10-,11-,20+/m1/s1
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15n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal domain of maltase-glucoamylase after 60 mins by glucose oxidase assay


Bioorg Med Chem Lett 20: 5686-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.020
BindingDB Entry DOI: 10.7270/Q2WQ0411
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50330961
PNG
((2R,3S,4S)-1-((2S,3S,4R,5R,6S)-2,3,4,5,6,7-hexahyd...)
Show SMILES OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)C[Se+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H25O9Se/c13-1-5(15)10(19)12(21)11(20)7(17)4-22-3-6(16)9(18)8(22)2-14/h5-21H,1-4H2/q+1/t5-,6+,7+,8+,9-,10+,11+,12+,22?/m0/s1
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20n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal subunit of maltase-glucoamylase after 60 mins by glucose oxidase assay


Bioorg Med Chem 18: 7794-8 (2010)


Article DOI: 10.1016/j.bmc.2010.09.059
BindingDB Entry DOI: 10.7270/Q2TT4RZH
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50291027
PNG
((2R,3R,4R,5S)-2-Hydroxymethyl-1-(4-trimethylsilany...)
Show SMILES C[Si](C)(C)c1ccc(CN2C[C@H](O)[C@@H](O)[C@H](O)[C@H]2CO)cc1
Show InChI InChI=1S/C16H27NO4Si/c1-22(2,3)12-6-4-11(5-7-12)8-17-9-14(19)16(21)15(20)13(17)10-18/h4-7,13-16,18-21H,8-10H2,1-3H3/t13-,14+,15-,16-/m1/s1
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28n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition constant against rat small intestinal glucoamylase


Bioorg Med Chem Lett 7: 355-360 (1997)


Article DOI: 10.1016/S0960-894X(97)00012-7
BindingDB Entry DOI: 10.7270/Q2F18ZQ1
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50330954
PNG
(CHEMBL1276973 | de-O-sulfonated kotalanol)
Show SMILES OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)C[S+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H25O9S/c13-1-5(15)10(19)12(21)11(20)7(17)4-22-3-6(16)9(18)8(22)2-14/h5-21H,1-4H2/q+1/t5-,6+,7+,8+,9-,10+,11+,12+,22?/m0/s1
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30n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal subunit of maltase-glucoamylase after 60 mins by glucose oxidase assay


Bioorg Med Chem 18: 7794-8 (2010)


Article DOI: 10.1016/j.bmc.2010.09.059
BindingDB Entry DOI: 10.7270/Q2TT4RZH
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50327502
PNG
((1R,2R,3S,4S)-3,4-dihydroxy-2-(hydroxymethyl)-1-((...)
Show SMILES OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C[S@@+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C11H23O8S/c12-1-5(14)10(18)11(19)7(16)4-20-3-6(15)9(17)8(20)2-13/h5-19H,1-4H2/q+1/t5-,6+,7+,8+,9-,10+,11+,20-/m0/s1
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43n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal maltase-glucoamylase


Bioorg Med Chem Lett 21: 6491-4 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.069
BindingDB Entry DOI: 10.7270/Q2Q81DHZ
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50327502
PNG
((1R,2R,3S,4S)-3,4-dihydroxy-2-(hydroxymethyl)-1-((...)
Show SMILES OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C[S@@+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C11H23O8S/c12-1-5(14)10(18)11(19)7(16)4-20-3-6(15)9(17)8(20)2-13/h5-19H,1-4H2/q+1/t5-,6+,7+,8+,9-,10+,11+,20-/m0/s1
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43n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal domain of maltase-glucoamylase after 60 mins by glucose oxidase assay


Bioorg Med Chem Lett 20: 5686-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.020
BindingDB Entry DOI: 10.7270/Q2WQ0411
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50291031
PNG
((2R,3R,4R,5S)-2-Hydroxymethyl-1-(3-trimethylsilany...)
Show SMILES C[Si](C)(C)CCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H27NO4Si/c1-18(2,3)6-4-5-13-7-10(15)12(17)11(16)9(13)8-14/h9-12,14-17H,4-8H2,1-3H3/t9-,10+,11-,12-/m1/s1
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50n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition constant against rat small intestinal glucoamylase


Bioorg Med Chem Lett 7: 355-360 (1997)


Article DOI: 10.1016/S0960-894X(97)00012-7
BindingDB Entry DOI: 10.7270/Q2F18ZQ1
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50330960
PNG
((2R,3R,4R)-1-((2R,3R,4S,5R,6S)-2,3,4,5,6,7-hexahyd...)
Show SMILES OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CN1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H25NO9/c14-3-5-9(19)6(16)1-13(5)2-7(17)10(20)12(22)11(21)8(18)4-15/h5-12,14-22H,1-4H2/t5-,6-,7-,8+,9-,10-,11-,12+/m1/s1
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60n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal subunit of maltase-glucoamylase after 60 mins by glucose oxidase assay


Bioorg Med Chem 18: 7794-8 (2010)


Article DOI: 10.1016/j.bmc.2010.09.059
BindingDB Entry DOI: 10.7270/Q2TT4RZH
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50291034
PNG
((2R,3R,4R,5S)-2-Hydroxymethyl-1-(5-trimethylsilany...)
Show SMILES C[Si](C)(C)CCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C14H31NO4Si/c1-20(2,3)8-6-4-5-7-15-9-12(17)14(19)13(18)11(15)10-16/h11-14,16-19H,4-10H2,1-3H3/t11-,12+,13-,14-/m1/s1
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70n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition constant against rat small intestinal glucoamylase


Bioorg Med Chem Lett 7: 355-360 (1997)


Article DOI: 10.1016/S0960-894X(97)00012-7
BindingDB Entry DOI: 10.7270/Q2F18ZQ1
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50330959
PNG
(CHEMBL1277153)
Show SMILES OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](OS([O-])(=O)=O)[C@H](O)C[Se+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H24O12SSe/c13-1-5(15)10(19)11(20)12(24-25(21,22)23)7(17)4-26-3-6(16)9(18)8(26)2-14/h5-20H,1-4H2/t5-,6+,7+,8+,9-,10+,11+,12+,26?/m0/s1
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80n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal subunit of maltase-glucoamylase after 60 mins by glucose oxidase assay


Bioorg Med Chem 18: 7794-8 (2010)


Article DOI: 10.1016/j.bmc.2010.09.059
BindingDB Entry DOI: 10.7270/Q2TT4RZH
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50291023
PNG
((2R,3R,4R,5S)-1-[(E)-3-(tert-Butyl-dimethyl-silany...)
Show SMILES CC(C)(C)[Si](C)(C)\C=C\CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C15H31NO4Si/c1-15(2,3)21(4,5)8-6-7-16-9-12(18)14(20)13(19)11(16)10-17/h6,8,11-14,17-20H,7,9-10H2,1-5H3/b8-6+/t11-,12+,13-,14-/m1/s1
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87n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition constant against rat small intestinal glucoamylase


Bioorg Med Chem Lett 7: 355-360 (1997)


Article DOI: 10.1016/S0960-894X(97)00012-7
BindingDB Entry DOI: 10.7270/Q2F18ZQ1
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50316180
PNG
((1S,2R,3S,4S)-1-{(1S)-2-[(2R,3S,4S)-3,4-dihydroxy-...)
Show SMILES OC[C@H](O)[C@H](O)[C@@H](O)[C@H](OS([O-])(=O)=O)[C@H](O)C[S+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H24O12S2/c13-1-5(15)10(19)11(20)12(24-26(21,22)23)7(17)4-25-3-6(16)9(18)8(25)2-14/h5-20H,1-4H2/t5-,6+,7+,8+,9-,10-,11+,12+,25?/m0/s1
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100n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human maltase glucoamylase N-terminal catalytic domain


Bioorg Med Chem 18: 2829-35 (2010)


Article DOI: 10.1016/j.bmc.2010.03.027
BindingDB Entry DOI: 10.7270/Q22B8Z5J
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50291021
PNG
((2R,3R,4R,5S)-2-Hydroxymethyl-1-(4-trimethylsilany...)
Show SMILES C[Si](C)(C)CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C13H29NO4Si/c1-19(2,3)7-5-4-6-14-8-11(16)13(18)12(17)10(14)9-15/h10-13,15-18H,4-9H2,1-3H3/t10-,11+,12-,13-/m1/s1
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120n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition constant against rat small intestinal glucoamylase


Bioorg Med Chem Lett 7: 355-360 (1997)


Article DOI: 10.1016/S0960-894X(97)00012-7
BindingDB Entry DOI: 10.7270/Q2F18ZQ1
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50316181
PNG
((1S,2R,3S,4R)-1-{(1S)-2-[(2R,3S,4S)-3,4-dihydroxy-...)
Show SMILES OC[C@@H](O)[C@H](O)[C@@H](O)[C@H](OS([O-])(=O)=O)[C@H](O)C[S+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H24O12S2/c13-1-5(15)10(19)11(20)12(24-26(21,22)23)7(17)4-25-3-6(16)9(18)8(25)2-14/h5-20H,1-4H2/t5-,6-,7-,8-,9+,10+,11-,12-,25?/m1/s1
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130n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human maltase glucoamylase N-terminal catalytic domain


Bioorg Med Chem 18: 2829-35 (2010)


Article DOI: 10.1016/j.bmc.2010.03.027
BindingDB Entry DOI: 10.7270/Q22B8Z5J
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50327501
PNG
(CHEMBL1258528 | ponkoranol)
Show SMILES OC[C@H](O)[C@@H](O)[C@H](OS([O-])(=O)=O)[C@H](O)C[S@@+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C11H22O11S2/c12-1-5(14)10(18)11(22-24(19,20)21)7(16)4-23-3-6(15)9(17)8(23)2-13/h5-18H,1-4H2/t5-,6+,7+,8+,9-,10+,11+,23-/m0/s1
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170n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal domain of maltase-glucoamylase after 60 mins by glucose oxidase assay


Bioorg Med Chem Lett 20: 5686-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.020
BindingDB Entry DOI: 10.7270/Q2WQ0411
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50316179
PNG
((1S,2R,3R,4S)-1-{(1S)-2-[(2R,3S,4S)-3,4-dihydroxy-...)
Show SMILES OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](OS([O-])(=O)=O)[C@H](O)C[S+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H24O12S2/c13-1-5(15)10(19)11(20)12(24-26(21,22)23)7(17)4-25-3-6(16)9(18)8(25)2-14/h5-20H,1-4H2/t5-,6+,7+,8+,9-,10+,11+,12+,25?/m0/s1
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190n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal subunit of maltase-glucoamylase after 60 mins by glucose oxidase assay


Bioorg Med Chem 18: 7794-8 (2010)


Article DOI: 10.1016/j.bmc.2010.09.059
BindingDB Entry DOI: 10.7270/Q2TT4RZH
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50316179
PNG
((1S,2R,3R,4S)-1-{(1S)-2-[(2R,3S,4S)-3,4-dihydroxy-...)
Show SMILES OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](OS([O-])(=O)=O)[C@H](O)C[S+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H24O12S2/c13-1-5(15)10(19)11(20)12(24-26(21,22)23)7(17)4-25-3-6(16)9(18)8(25)2-14/h5-20H,1-4H2/t5-,6+,7+,8+,9-,10+,11+,12+,25?/m0/s1
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190n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human maltase glucoamylase N-terminal catalytic domain


Bioorg Med Chem 18: 2829-35 (2010)


Article DOI: 10.1016/j.bmc.2010.03.027
BindingDB Entry DOI: 10.7270/Q22B8Z5J
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50316178
PNG
(1,4-Dideoxy-1,4-[[2S,3S,4R,5R,6R-2,4,5,6,7-pentahy...)
Show SMILES OC[C@@H](O)[C@@H](O)[C@@H](O)[C@H](OS([O-])(=O)=O)[C@H](O)C[S+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H24O12S2/c13-1-5(15)10(19)11(20)12(24-26(21,22)23)7(17)4-25-3-6(16)9(18)8(25)2-14/h5-20H,1-4H2/t5-,6-,7-,8-,9+,10-,11-,12-,25?/m1/s1
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200n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human maltase glucoamylase N-terminal catalytic domain


Bioorg Med Chem 18: 2829-35 (2010)


Article DOI: 10.1016/j.bmc.2010.03.027
BindingDB Entry DOI: 10.7270/Q22B8Z5J
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50408432
PNG
(CHEMBL2115215)
Show SMILES OC[C@H]1N[C@@H](CO)[C@@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C7H15NO5/c9-1-3-5(11)7(13)6(12)4(2-10)8-3/h3-13H,1-2H2/t3-,4+,5-,6-,7+/m1/s1
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450n/an/an/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against alpha-glucosidase


J Med Chem 41: 2565-71 (1998)


Article DOI: 10.1021/jm970836l
BindingDB Entry DOI: 10.7270/Q25D8SHK
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50327504
PNG
(1,4-Dideoxy-1,4-[[2S,3S,4R,5S]-2,4,5,6-tetrahydrox...)
Show SMILES CO[C@H]([C@H](O)C[S@@+]1C[C@@H](O)[C@H](O)[C@H]1CO)[C@H](O)[C@@H](O)CO
Show InChI InChI=1S/C12H25O8S/c1-20-12(11(19)6(15)2-13)8(17)5-21-4-7(16)10(18)9(21)3-14/h6-19H,2-5H2,1H3/q+1/t6-,7+,8+,9+,10-,11+,12+,21-/m0/s1
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500n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal maltase-glucoamylase


Bioorg Med Chem Lett 21: 6491-4 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.069
BindingDB Entry DOI: 10.7270/Q2Q81DHZ
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50327504
PNG
(1,4-Dideoxy-1,4-[[2S,3S,4R,5S]-2,4,5,6-tetrahydrox...)
Show SMILES CO[C@H]([C@H](O)C[S@@+]1C[C@@H](O)[C@H](O)[C@H]1CO)[C@H](O)[C@@H](O)CO
Show InChI InChI=1S/C12H25O8S/c1-20-12(11(19)6(15)2-13)8(17)5-21-4-7(16)10(18)9(21)3-14/h6-19H,2-5H2,1H3/q+1/t6-,7+,8+,9+,10-,11+,12+,21-/m0/s1
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500n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal maltase-glucoamylase by Lineweaver-Burk plot analysis


Bioorg Med Chem Lett 21: 6491-4 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.069
BindingDB Entry DOI: 10.7270/Q2Q81DHZ
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50327504
PNG
(1,4-Dideoxy-1,4-[[2S,3S,4R,5S]-2,4,5,6-tetrahydrox...)
Show SMILES CO[C@H]([C@H](O)C[S@@+]1C[C@@H](O)[C@H](O)[C@H]1CO)[C@H](O)[C@@H](O)CO
Show InChI InChI=1S/C12H25O8S/c1-20-12(11(19)6(15)2-13)8(17)5-21-4-7(16)10(18)9(21)3-14/h6-19H,2-5H2,1H3/q+1/t6-,7+,8+,9+,10-,11+,12+,21-/m0/s1
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500n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal domain of maltase-glucoamylase after 60 mins by glucose oxidase assay


Bioorg Med Chem Lett 20: 5686-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.020
BindingDB Entry DOI: 10.7270/Q2WQ0411
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50291028
PNG
((2R,3R,4R,5S)-1-(Dimethyl-propyl-silanylmethyl)-2-...)
Show SMILES CCC[Si](C)(C)CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H27NO4Si/c1-4-5-18(2,3)8-13-6-10(15)12(17)11(16)9(13)7-14/h9-12,14-17H,4-8H2,1-3H3/t9-,10+,11-,12-/m1/s1
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900n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition constant against rat small intestinal glucoamylase


Bioorg Med Chem Lett 7: 355-360 (1997)


Article DOI: 10.1016/S0960-894X(97)00012-7
BindingDB Entry DOI: 10.7270/Q2F18ZQ1
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50330955
PNG
((1S,2S)-3-[(2R,3S,4S)-3,4-dihydroxy-2-(hydroxymeth...)
Show SMILES OC[C@H](OS([O-])(=O)=O)[C@H](O)C[S@@+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C9H18O9S2/c10-1-7(18-20(15,16)17)5(12)3-19-4-6(13)9(14)8(19)2-11/h5-14H,1-4H2/t5-,6-,7+,8-,9+,19-/m1/s1
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1.00E+3n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal subunit of maltase-glucoamylase after 60 mins by glucose oxidase assay


Bioorg Med Chem 18: 7794-8 (2010)


Article DOI: 10.1016/j.bmc.2010.09.059
BindingDB Entry DOI: 10.7270/Q2TT4RZH
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50291032
PNG
((2R,3R,4R,5S)-2-Hydroxymethyl-1-(3-trimethylsilany...)
Show SMILES C[Si](C)(C)c1cccc(CN2C[C@H](O)[C@@H](O)[C@H](O)[C@H]2CO)c1
Show InChI InChI=1S/C16H27NO4Si/c1-22(2,3)12-6-4-5-11(7-12)8-17-9-14(19)16(21)15(20)13(17)10-18/h4-7,13-16,18-21H,8-10H2,1-3H3/t13-,14+,15-,16-/m1/s1
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1.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition constant against rat small intestinal glucoamylase


Bioorg Med Chem Lett 7: 355-360 (1997)


Article DOI: 10.1016/S0960-894X(97)00012-7
BindingDB Entry DOI: 10.7270/Q2F18ZQ1
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50242271
PNG
((2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)...)
Show SMILES OCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C8H17NO5/c10-2-1-9-3-6(12)8(14)7(13)5(9)4-11/h5-8,10-14H,1-4H2/t5-,6+,7-,8-/m1/s1
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1.00E+3n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal subunit of maltase-glucoamylase after 60 mins by glucose oxidase assay


Bioorg Med Chem 18: 7794-8 (2010)


Article DOI: 10.1016/j.bmc.2010.09.059
BindingDB Entry DOI: 10.7270/Q2TT4RZH
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50330957
PNG
(7'-[(1,5-Dideoxy-1,5-imino-D-glucitol)-5-N-ammoniu...)
Show SMILES OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C13H27NO10/c15-3-5-9(20)10(21)6(17)1-14(5)2-7(18)11(22)13(24)12(23)8(19)4-16/h5-13,15-24H,1-4H2/t5-,6+,7-,8+,9-,10-,11-,12-,13+/m1/s1
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1.40E+3n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal subunit of maltase-glucoamylase after 60 mins by glucose oxidase assay


Bioorg Med Chem 18: 7794-8 (2010)


Article DOI: 10.1016/j.bmc.2010.09.059
BindingDB Entry DOI: 10.7270/Q2TT4RZH
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50330956
PNG
(7'-[(1,5-Dideoxy-1,5-imino-D-glucitol)-5-N-ammoniu...)
Show SMILES OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](OS([O-])(=O)=O)[C@H](O)C[NH+]1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C13H27NO13S/c15-3-5-9(20)10(21)6(17)1-14(5)2-7(18)13(27-28(24,25)26)12(23)11(22)8(19)4-16/h5-13,15-23H,1-4H2,(H,24,25,26)/t5-,6+,7-,8+,9-,10-,11-,12-,13-/m1/s1
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2.30E+3n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal subunit of maltase-glucoamylase after 60 mins by glucose oxidase assay


Bioorg Med Chem 18: 7794-8 (2010)


Article DOI: 10.1016/j.bmc.2010.09.059
BindingDB Entry DOI: 10.7270/Q2TT4RZH
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50291022
PNG
((2R,3R,4R,5S)-2-Hydroxymethyl-1-trimethylsilanylme...)
Show SMILES C[Si](C)(C)CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C10H23NO4Si/c1-16(2,3)6-11-4-8(13)10(15)9(14)7(11)5-12/h7-10,12-15H,4-6H2,1-3H3/t7-,8+,9-,10-/m1/s1
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2.50E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition constant against rat small intestinal glucoamylase


Bioorg Med Chem Lett 7: 355-360 (1997)


Article DOI: 10.1016/S0960-894X(97)00012-7
BindingDB Entry DOI: 10.7270/Q2F18ZQ1
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50291033
PNG
((2R,3R,4R,5S)-1-[(Dimethyl-phenyl-silanyl)-methyl]...)
Show SMILES C[Si](C)(CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO)c1ccccc1
Show InChI InChI=1S/C15H25NO4Si/c1-21(2,11-6-4-3-5-7-11)10-16-8-13(18)15(20)14(19)12(16)9-17/h3-7,12-15,17-20H,8-10H2,1-2H3/t12-,13+,14-,15-/m1/s1
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2.60E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition constant against rat small intestinal glucoamylase


Bioorg Med Chem Lett 7: 355-360 (1997)


Article DOI: 10.1016/S0960-894X(97)00012-7
BindingDB Entry DOI: 10.7270/Q2F18ZQ1
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50408431
PNG
(CHEMBL2114210)
Show SMILES OC[C@H]1N[C@H](CO)[C@@H](O)C(O)[C@@H]1O
Show InChI InChI=1S/C7H15NO5/c9-1-3-5(11)7(13)6(12)4(2-10)8-3/h3-13H,1-2H2/t3-,4-,5-,6-/m1/s1
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6.20E+3n/an/an/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against alpha-glucosidase


J Med Chem 41: 2565-71 (1998)


Article DOI: 10.1021/jm970836l
BindingDB Entry DOI: 10.7270/Q25D8SHK
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50065255
PNG
((R)-2,6-Bis-hydroxymethyl-piperidine-3,4,5-triol |...)
Show SMILES OCC1NC(CO)[C@@H](O)C(O)C1O
Show InChI InChI=1S/C7H15NO5/c9-1-3-5(11)7(13)6(12)4(2-10)8-3/h3-13H,1-2H2/t3?,4?,5-,6?,7?/m1/s1
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6.90E+3n/an/an/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against alpha-glucosidase


J Med Chem 41: 2565-71 (1998)


Article DOI: 10.1021/jm970836l
BindingDB Entry DOI: 10.7270/Q25D8SHK
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50291024
PNG
((2R,3R,4R,5S)-2-Hydroxymethyl-1-(2-trimethylsilany...)
Show SMILES C[Si](C)(C)c1ccccc1CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C16H27NO4Si/c1-22(2,3)14-7-5-4-6-11(14)8-17-9-13(19)16(21)15(20)12(17)10-18/h4-7,12-13,15-16,18-21H,8-10H2,1-3H3/t12-,13+,15-,16-/m1/s1
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1.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition constant against rat small intestinal glucoamylase


Bioorg Med Chem Lett 7: 355-360 (1997)


Article DOI: 10.1016/S0960-894X(97)00012-7
BindingDB Entry DOI: 10.7270/Q2F18ZQ1
More data for this
Ligand-Target Pair
Alpha glucosidase


(Homo sapiens (Human))
BDBM19459
PNG
(5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one...)
Show SMILES Oc1ccc(cc1)-c1coc2cc(O)cc(O)c2c1=O
Show InChI InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15(11)19/h1-7,16-18H
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1.04E+4n/an/an/an/an/an/an/an/a



SUN Yat-sen (Zhongshan) University

Curated by ChEMBL


Assay Description
Inhibition of yeast alpha-glucosidase by genistein


Bioorg Med Chem Lett 14: 2947-50 (2004)


Article DOI: 10.1016/j.bmcl.2004.03.035
BindingDB Entry DOI: 10.7270/Q2QR4WKM
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50330958
PNG
((2R,3R,4R,5R,6S)-1-((2R,3R,4R)-3,4-dihydroxy-2-(hy...)
Show SMILES OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](OS([O-])(=O)=O)[C@H](O)C[NH+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H25NO12S/c14-3-5-9(19)6(16)1-13(5)2-7(17)12(25-26(22,23)24)11(21)10(20)8(18)4-15/h5-12,14-21H,1-4H2,(H,22,23,24)/t5-,6-,7-,8+,9-,10-,11-,12-/m1/s1
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9.00E+4n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal subunit of maltase-glucoamylase after 60 mins by glucose oxidase assay


Bioorg Med Chem 18: 7794-8 (2010)


Article DOI: 10.1016/j.bmc.2010.09.059
BindingDB Entry DOI: 10.7270/Q2TT4RZH
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM19459
PNG
(5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one...)
Show SMILES Oc1ccc(cc1)-c1coc2cc(O)cc(O)c2c1=O
Show InChI InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15(11)19/h1-7,16-18H
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n/an/a 2.61E+3n/an/an/an/an/an/a



SUN Yat-sen (Zhongshan) University

Curated by ChEMBL


Assay Description
Inhibition of yeast alpha-glucosidase after addition of D-glucose


Bioorg Med Chem Lett 14: 2947-50 (2004)


Article DOI: 10.1016/j.bmcl.2004.03.035
BindingDB Entry DOI: 10.7270/Q2QR4WKM
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50031482
PNG
((2R,3R,4R,5R)-1-Butyl-2,5-bis-hydroxymethyl-pyrrol...)
Show SMILES CCCCN1[C@H](CO)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-7(5-12)9(14)10(15)8(11)6-13/h7-10,12-15H,2-6H2,1H3/t7-,8-,9-,10-/m1/s1
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n/an/a<5.00E+4n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of Glycosidases (maltase) in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method maltase


J Med Chem 38: 2349-56 (1995)


Article DOI: 10.1021/jm00013a012
BindingDB Entry DOI: 10.7270/Q2N878T0
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50031483
PNG
((2R,3R,4R,5R)-2,5-Bis-hydroxymethyl-1-methyl-pyrro...)
Show SMILES CN1[C@H](CO)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C7H15NO4/c1-8-4(2-9)6(11)7(12)5(8)3-10/h4-7,9-12H,2-3H2,1H3/t4-,5-,6-,7-/m1/s1
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n/an/a<5.00E+4n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of Glycosidases (maltase) in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method maltase


J Med Chem 38: 2349-56 (1995)


Article DOI: 10.1021/jm00013a012
BindingDB Entry DOI: 10.7270/Q2N878T0
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM18351
PNG
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
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n/an/a 360n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of Glycosidases (maltase) in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method


J Med Chem 38: 2349-56 (1995)


Article DOI: 10.1021/jm00013a012
BindingDB Entry DOI: 10.7270/Q2N878T0
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50031481
PNG
((2R,3R,4R,5R)-2,5-Bis-hydroxymethyl-pyrrolidine-3,...)
Show SMILES OC[C@H]1N[C@H](CO)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-1-3-5(10)6(11)4(2-9)7-3/h3-11H,1-2H2/t3-,4-,5-,6-/m1/s1
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n/an/a<5.00E+4n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of Glycosidases (maltase) in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method maltase


J Med Chem 38: 2349-56 (1995)


Article DOI: 10.1021/jm00013a012
BindingDB Entry DOI: 10.7270/Q2N878T0
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50016703
PNG
(2-Hydroxymethyl-pyrrolidine-3,4-diol | BDBM5003148...)
Show SMILES OC[C@H]1NC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C5H11NO3/c7-2-3-5(9)4(8)1-6-3/h3-9H,1-2H2/t3-,4-,5?/m1/s1
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n/an/a 5.50E+4n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of Glycosidases (maltase) in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method


J Med Chem 38: 2349-56 (1995)


Article DOI: 10.1021/jm00013a012
BindingDB Entry DOI: 10.7270/Q2N878T0
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50031480
PNG
((2R,3R,4R)-2-Hydroxymethyl-1-methyl-pyrrolidine-3,...)
Show SMILES CN1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C6H13NO3/c1-7-2-5(9)6(10)4(7)3-8/h4-6,8-10H,2-3H2,1H3/t4-,5-,6-/m1/s1
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n/an/a 5.00E+5n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of Glycosidases (maltase) in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method maltase


J Med Chem 38: 2349-56 (1995)


Article DOI: 10.1021/jm00013a012
BindingDB Entry DOI: 10.7270/Q2N878T0
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM18355
PNG
((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)
Show SMILES CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1
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n/an/a 2.10E+3n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of Glycosidases (maltase) in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method maltase


J Med Chem 38: 2349-56 (1995)


Article DOI: 10.1021/jm00013a012
BindingDB Entry DOI: 10.7270/Q2N878T0
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM18353
PNG
((2R,3R,4R,5S)-2-(hydroxymethyl)-1-methylpiperidine...)
Show SMILES CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C7H15NO4/c1-8-2-5(10)7(12)6(11)4(8)3-9/h4-7,9-12H,2-3H2,1H3/t4-,5+,6-,7-/m1/s1
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n/an/a 120n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibition of Glycosidases (maltase) in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method maltase


J Med Chem 38: 2349-56 (1995)


Article DOI: 10.1021/jm00013a012
BindingDB Entry DOI: 10.7270/Q2N878T0
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50065255
PNG
((R)-2,6-Bis-hydroxymethyl-piperidine-3,4,5-triol |...)
Show SMILES OCC1NC(CO)[C@@H](O)C(O)C1O
Show InChI InChI=1S/C7H15NO5/c9-1-3-5(11)7(13)6(12)4(2-10)8-3/h3-13H,1-2H2/t3?,4?,5-,6?,7?/m1/s1
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n/an/a 700n/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibitory activity measured against alpha-glucosidase of rice by colorimetric assay using the D-glucose oxidase-peroxidase method


J Med Chem 41: 2565-71 (1998)


Article DOI: 10.1021/jm970836l
BindingDB Entry DOI: 10.7270/Q25D8SHK
More data for this
Ligand-Target Pair
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