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Compile Data Set for Download or QSAR

Found 5377 hits Enz. Inhib. hit(s) with Target = 'Melanocortin receptor 4'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM230656
PNG
(US9340517, 105)
Show SMILES NC(=N)NCCC[C@H]1N[C@@H](CNC(=O)c2ccc3ccccc3c2)CCN(CC(c2ccccc2)c2ccccc2)C1=O
Show InChI InChI=1S/C35H40N6O2/c36-35(37)38-20-9-16-32-34(43)41(24-31(26-11-3-1-4-12-26)27-13-5-2-6-14-27)21-19-30(40-32)23-39-33(42)29-18-17-25-10-7-8-15-28(25)22-29/h1-8,10-15,17-18,22,30-32,40H,9,16,19-21,23-24H2,(H,39,42)(H4,36,37,38)/t30-,32-/m1/s1
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n/an/a 3.28E+3n/an/an/an/a7.44



Mimetica PTY LTD

US Patent


Assay Description
Radioligand binding assays were carried out using commercial or in-house prepared hMC1R, hMC3R and hMC4R membranes and [125I] NDP-MSH, as per the hMC...


US Patent US9340517 (2016)


BindingDB Entry DOI: 10.7270/Q2PV6J8X
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM230659
PNG
(US9340517, 348)
Show SMILES CCC(CC)CN1CC[C@H](CNC(=O)\C=C\c2ccc(Cl)cc2)N[C@H](CCN2CCCCC2)C1=O
Show InChI InChI=1S/C28H43ClN4O2/c1-3-22(4-2)21-33-19-14-25(20-30-27(34)13-10-23-8-11-24(29)12-9-23)31-26(28(33)35)15-18-32-16-6-5-7-17-32/h8-13,22,25-26,31H,3-7,14-21H2,1-2H3,(H,30,34)/b13-10+/t25-,26-/m1/s1
KEGG

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n/an/a 2.00E+4n/an/an/an/a7.44



Mimetica PTY LTD

US Patent


Assay Description
Radioligand binding assays were carried out using commercial or in-house prepared hMC1R, hMC3R and hMC4R membranes and [125I] NDP-MSH, as per the hMC...


US Patent US9340517 (2016)


BindingDB Entry DOI: 10.7270/Q2PV6J8X
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM230658
PNG
(US9340517, 33)
Show SMILES Clc1ccc(\C=C\C(=O)NC[C@H]2CCN(CC(c3ccccc3)c3ccccc3)C(=O)[C@@H](CCN3CCCCC3)N2)cc1
Show InChI InChI=1S/C36H43ClN4O2/c37-31-17-14-28(15-18-31)16-19-35(42)38-26-32-20-25-41(36(43)34(39-32)21-24-40-22-8-3-9-23-40)27-33(29-10-4-1-5-11-29)30-12-6-2-7-13-30/h1-2,4-7,10-19,32-34,39H,3,8-9,20-27H2,(H,38,42)/b19-16+/t32-,34-/m1/s1
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n/an/a 6.06E+3n/an/an/an/a7.44



Mimetica PTY LTD

US Patent


Assay Description
Radioligand binding assays were carried out using commercial or in-house prepared hMC1R, hMC3R and hMC4R membranes and [125I] NDP-MSH, as per the hMC...


US Patent US9340517 (2016)


BindingDB Entry DOI: 10.7270/Q2PV6J8X
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM230657
PNG
(US9340517, 64)
Show SMILES O=C(NC[C@H]1CCN(CC(c2ccccc2)c2ccccc2)C(=O)[C@@H](CCCN2CCCCC2)N1)c1ccc2ccccc2c1
Show InChI InChI=1S/C39H46N4O2/c44-38(34-21-20-30-13-8-9-18-33(30)27-34)40-28-35-22-26-43(39(45)37(41-35)19-12-25-42-23-10-3-11-24-42)29-36(31-14-4-1-5-15-31)32-16-6-2-7-17-32/h1-2,4-9,13-18,20-21,27,35-37,41H,3,10-12,19,22-26,28-29H2,(H,40,44)/t35-,37-/m1/s1
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n/an/a 3.49E+3n/an/an/an/a7.44



Mimetica PTY LTD

US Patent


Assay Description
Radioligand binding assays were carried out using commercial or in-house prepared hMC1R, hMC3R and hMC4R membranes and [125I] NDP-MSH, as per the hMC...


US Patent US9340517 (2016)


BindingDB Entry DOI: 10.7270/Q2PV6J8X
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM160159
PNG
(US9040663, 5)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccc(Cl)c(Cl)c2)NC(=O)[C@H](CCN)NC1=O)C(N)=O
Show InChI InChI=1S/C48H69Cl2N17O9/c1-25(68)61-33(10-5-19-58-47(53)54)41(71)64-35-14-15-39(69)57-18-4-9-32(40(52)70)62-46(76)38(23-27-24-60-31-8-3-2-7-28(27)31)67-42(72)34(11-6-20-59-48(55)56)63-45(75)37(22-26-12-13-29(49)30(50)21-26)66-44(74)36(16-17-51)65-43(35)73/h2-3,7-8,12-13,21,24,32-38,60H,4-6,9-11,14-20,22-23,51H2,1H3,(H2,52,70)(H,57,69)(H,61,68)(H,62,76)(H,63,75)(H,64,71)(H,65,73)(H,66,74)(H,67,72)(H4,53,54,58)(H4,55,56,59)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
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US Patent
0.0550 -60.9n/an/an/an/an/a7.537



AstraZeneca AB

US Patent


Assay Description
A competitive inhibition binding assay was performed for exemplified peptides according to the invention using membrane homogenates prepared from HEK...


US Patent US9040663 (2015)


BindingDB Entry DOI: 10.7270/Q29885SK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM160158
PNG
(US9040663, 4)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccc(Cl)cc2Cl)NC(=O)[C@H](CCN)NC1=O)C(N)=O
Show InChI InChI=1S/C48H69Cl2N17O9/c1-25(68)61-33(10-5-19-58-47(53)54)41(71)64-35-14-15-39(69)57-18-4-9-32(40(52)70)62-45(75)38(22-27-24-60-31-8-3-2-7-29(27)31)67-42(72)34(11-6-20-59-48(55)56)63-46(76)37(21-26-12-13-28(49)23-30(26)50)66-44(74)36(16-17-51)65-43(35)73/h2-3,7-8,12-13,23-24,32-38,60H,4-6,9-11,14-22,51H2,1H3,(H2,52,70)(H,57,69)(H,61,68)(H,62,75)(H,63,76)(H,64,71)(H,65,73)(H,66,74)(H,67,72)(H4,53,54,58)(H4,55,56,59)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
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0.0550 -60.9n/an/an/an/an/a7.537



AstraZeneca AB

US Patent


Assay Description
A competitive inhibition binding assay was performed for exemplified peptides according to the invention using membrane homogenates prepared from HEK...


US Patent US9040663 (2015)


BindingDB Entry DOI: 10.7270/Q29885SK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM160174
PNG
(US9040663, 20)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccc(cc2)C(F)(F)F)NC(=O)[C@H](CCN)NC1=O)C(N)=O
Show InChI InChI=1S/C49H70F3N17O9/c1-26(70)63-33(10-5-21-60-47(55)56)41(73)66-35-16-17-39(71)59-20-4-9-32(40(54)72)64-46(78)38(24-28-25-62-31-8-3-2-7-30(28)31)69-42(74)34(11-6-22-61-48(57)58)65-45(77)37(68-44(76)36(18-19-53)67-43(35)75)23-27-12-14-29(15-13-27)49(50,51)52/h2-3,7-8,12-15,25,32-38,62H,4-6,9-11,16-24,53H2,1H3,(H2,54,72)(H,59,71)(H,63,70)(H,64,78)(H,65,77)(H,66,73)(H,67,75)(H,68,76)(H,69,74)(H4,55,56,60)(H4,57,58,61)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
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0.0600 -60.7n/an/an/an/an/a7.537



AstraZeneca AB

US Patent


Assay Description
A competitive inhibition binding assay was performed for exemplified peptides according to the invention using membrane homogenates prepared from HEK...


US Patent US9040663 (2015)


BindingDB Entry DOI: 10.7270/Q29885SK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM160157
PNG
(US9040663, 3)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H](CCN)NC1=O)C(N)=O
Show InChI InChI=1S/C48H70ClN17O9/c1-26(67)60-33(10-5-21-57-47(52)53)41(70)63-35-16-17-39(68)56-20-4-9-32(40(51)69)61-46(75)38(24-28-25-59-31-8-3-2-7-30(28)31)66-42(71)34(11-6-22-58-48(54)55)62-45(74)37(23-27-12-14-29(49)15-13-27)65-44(73)36(18-19-50)64-43(35)72/h2-3,7-8,12-15,25,32-38,59H,4-6,9-11,16-24,50H2,1H3,(H2,51,69)(H,56,68)(H,60,67)(H,61,75)(H,62,74)(H,63,70)(H,64,72)(H,65,73)(H,66,71)(H4,52,53,57)(H4,54,55,58)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
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0.0800 -59.9n/an/an/an/an/a7.537



AstraZeneca AB

US Patent


Assay Description
A competitive inhibition binding assay was performed for exemplified peptides according to the invention using membrane homogenates prepared from HEK...


US Patent US9040663 (2015)


BindingDB Entry DOI: 10.7270/Q29885SK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM160175
PNG
(US9040663, 21)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccc(C)cc2C)NC(=O)[C@H](CCN)NC1=O)C(N)=O
Show InChI InChI=1S/C50H75N17O9/c1-27-14-15-30(28(2)23-27)24-39-48(76)63-36(13-8-22-59-50(55)56)44(72)67-40(25-31-26-60-33-10-5-4-9-32(31)33)47(75)62-34(42(52)70)11-6-20-57-41(69)17-16-37(45(73)65-38(18-19-51)46(74)66-39)64-43(71)35(61-29(3)68)12-7-21-58-49(53)54/h4-5,9-10,14-15,23,26,34-40,60H,6-8,11-13,16-22,24-25,51H2,1-3H3,(H2,52,70)(H,57,69)(H,61,68)(H,62,75)(H,63,76)(H,64,71)(H,65,73)(H,66,74)(H,67,72)(H4,53,54,58)(H4,55,56,59)/t34-,35-,36-,37-,38-,39+,40-/m0/s1
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0.0850 -59.8n/an/an/an/an/a7.537



AstraZeneca AB

US Patent


Assay Description
A competitive inhibition binding assay was performed for exemplified peptides according to the invention using membrane homogenates prepared from HEK...


US Patent US9040663 (2015)


BindingDB Entry DOI: 10.7270/Q29885SK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM250643
PNG
(US9447148, 9.11)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCC(=O)NCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O
Show InChI InChI=1S/C51H68N14O9/c1-3-4-15-36(59-30(2)66)45(69)61-38-19-20-43(67)56-23-21-39(48(72)63-40(44(52)68)26-32-17-18-33-13-8-9-14-34(33)24-32)62-46(70)37(16-10-22-57-51(53)54)60-49(73)41(25-31-11-6-5-7-12-31)64-50(74)42(65-47(38)71)27-35-28-55-29-58-35/h5-9,11-14,17-18,24,28-29,36-42H,3-4,10,15-16,19-23,25-27H2,1-2H3,(H2,52,68)(H,55,58)(H,56,67)(H,59,66)(H,60,73)(H,61,69)(H,62,70)(H,63,72)(H,64,74)(H,65,71)(H4,53,54,57)/t36-,37-,38-,39-,40+,41+,42-/m0/s1
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0.0950 -59.5n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMCR-1a or hMCR-...


US Patent US9447148 (2016)


BindingDB Entry DOI: 10.7270/Q2RJ4HD2
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM160169
PNG
(US9040663, 15)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccc(C)cc2)NC(=O)[C@H](CCN)NC1=O)C(N)=O
Show InChI InChI=1S/C49H73N17O9/c1-27-13-15-29(16-14-27)24-38-46(74)62-35(12-7-23-58-49(54)55)43(71)66-39(25-30-26-59-32-9-4-3-8-31(30)32)47(75)61-33(41(51)69)10-5-21-56-40(68)18-17-36(44(72)64-37(19-20-50)45(73)65-38)63-42(70)34(60-28(2)67)11-6-22-57-48(52)53/h3-4,8-9,13-16,26,33-39,59H,5-7,10-12,17-25,50H2,1-2H3,(H2,51,69)(H,56,68)(H,60,67)(H,61,75)(H,62,74)(H,63,70)(H,64,72)(H,65,73)(H,66,71)(H4,52,53,57)(H4,54,55,58)/t33-,34-,35-,36-,37-,38+,39-/m0/s1
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0.145 -58.4n/an/an/an/an/a7.537



AstraZeneca AB

US Patent


Assay Description
A competitive inhibition binding assay was performed for exemplified peptides according to the invention using membrane homogenates prepared from HEK...


US Patent US9040663 (2015)


BindingDB Entry DOI: 10.7270/Q29885SK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM160208
PNG
(US9040663, 54)
Show SMILES CC(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccc(F)c(F)c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H68F2N18O9/c1-26(71)64-35(9-5-17-60-49(54)55)43(74)66-36-10-4-16-59-41(72)15-14-34(42(53)73)65-47(78)39(21-28-23-62-33-8-3-2-7-30(28)33)69-44(75)37(11-6-18-61-50(56)57)67-46(77)38(20-27-12-13-31(51)32(52)19-27)68-48(79)40(70-45(36)76)22-29-24-58-25-63-29/h2-3,7-8,12-13,19,23-25,34-40,62H,4-6,9-11,14-18,20-22H2,1H3,(H2,53,73)(H,58,63)(H,59,72)(H,64,71)(H,65,78)(H,66,74)(H,67,77)(H,68,79)(H,69,75)(H,70,76)(H4,54,55,60)(H4,56,57,61)/t34-,35+,36-,37-,38+,39-,40-/m0/s1
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0.25 -57.0n/an/an/an/an/a7.537



AstraZeneca AB

US Patent


Assay Description
A competitive inhibition binding assay was performed for exemplified peptides according to the invention using membrane homogenates prepared from HEK...


US Patent US9040663 (2015)


BindingDB Entry DOI: 10.7270/Q29885SK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM160165
PNG
(US9040663, 11)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@H](CCN)NC1=O)C(N)=O
Show InChI InChI=1S/C48H70FN17O9/c1-26(67)60-33(10-5-21-57-47(52)53)41(70)63-35-16-17-39(68)56-20-4-9-32(40(51)69)61-46(75)38(24-28-25-59-31-8-3-2-7-30(28)31)66-42(71)34(11-6-22-58-48(54)55)62-45(74)37(23-27-12-14-29(49)15-13-27)65-44(73)36(18-19-50)64-43(35)72/h2-3,7-8,12-15,25,32-38,59H,4-6,9-11,16-24,50H2,1H3,(H2,51,69)(H,56,68)(H,60,67)(H,61,75)(H,62,74)(H,63,70)(H,64,72)(H,65,73)(H,66,71)(H4,52,53,57)(H4,54,55,58)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
KEGG

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0.25 -57.0n/an/an/an/an/a7.537



AstraZeneca AB

US Patent


Assay Description
A competitive inhibition binding assay was performed for exemplified peptides according to the invention using membrane homogenates prepared from HEK...


US Patent US9040663 (2015)


BindingDB Entry DOI: 10.7270/Q29885SK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM160170
PNG
(US9040663, 16)
Show SMILES COc1ccc(C[C@H]2NC(=O)[C@H](CCN)NC(=O)[C@H](CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)cc1
Show InChI InChI=1S/C49H73N17O10/c1-27(67)60-34(11-6-22-57-48(52)53)42(70)63-36-17-18-40(68)56-21-5-10-33(41(51)69)61-47(75)39(25-29-26-59-32-9-4-3-8-31(29)32)66-43(71)35(12-7-23-58-49(54)55)62-46(74)38(24-28-13-15-30(76-2)16-14-28)65-45(73)37(19-20-50)64-44(36)72/h3-4,8-9,13-16,26,33-39,59H,5-7,10-12,17-25,50H2,1-2H3,(H2,51,69)(H,56,68)(H,60,67)(H,61,75)(H,62,74)(H,63,70)(H,64,72)(H,65,73)(H,66,71)(H4,52,53,57)(H4,54,55,58)/t33-,34-,35-,36-,37-,38+,39-/m0/s1
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0.25 -57.0n/an/an/an/an/a7.537



AstraZeneca AB

US Patent


Assay Description
A competitive inhibition binding assay was performed for exemplified peptides according to the invention using membrane homogenates prepared from HEK...


US Patent US9040663 (2015)


BindingDB Entry DOI: 10.7270/Q29885SK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM160201
PNG
(US9040663, 47)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2Cl)NC(=O)[C@H](COCc2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C54H73ClN16O10/c1-31(72)65-39(19-10-24-62-53(57)58)47(75)68-41-21-22-45(73)61-23-9-18-38(46(56)74)66-50(78)43(27-34-28-64-37-17-8-6-15-35(34)37)69-48(76)40(20-11-25-63-54(59)60)67-51(79)42(26-33-14-5-7-16-36(33)55)70-52(80)44(71-49(41)77)30-81-29-32-12-3-2-4-13-32/h2-8,12-17,28,38-44,64H,9-11,18-27,29-30H2,1H3,(H2,56,74)(H,61,73)(H,65,72)(H,66,78)(H,67,79)(H,68,75)(H,69,76)(H,70,80)(H,71,77)(H4,57,58,62)(H4,59,60,63)/t38-,39-,40-,41-,42+,43-,44-/m0/s1
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0.300 -56.5n/an/an/an/an/a7.537



AstraZeneca AB

US Patent


Assay Description
A competitive inhibition binding assay was performed for exemplified peptides according to the invention using membrane homogenates prepared from HEK...


US Patent US9040663 (2015)


BindingDB Entry DOI: 10.7270/Q29885SK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM160180
PNG
(US9040663, 26)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccc(F)c(F)c2)NC(=O)[C@H](CCN)NC1=O)C(N)=O
Show InChI InChI=1S/C48H69F2N17O9/c1-25(68)61-33(10-5-19-58-47(53)54)41(71)64-35-14-15-39(69)57-18-4-9-32(40(52)70)62-46(76)38(23-27-24-60-31-8-3-2-7-28(27)31)67-42(72)34(11-6-20-59-48(55)56)63-45(75)37(22-26-12-13-29(49)30(50)21-26)66-44(74)36(16-17-51)65-43(35)73/h2-3,7-8,12-13,21,24,32-38,60H,4-6,9-11,14-20,22-23,51H2,1H3,(H2,52,70)(H,57,69)(H,61,68)(H,62,76)(H,63,75)(H,64,71)(H,65,73)(H,66,74)(H,67,72)(H4,53,54,58)(H4,55,56,59)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
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0.300 -56.5n/an/an/an/an/a7.537



AstraZeneca AB

US Patent


Assay Description
A competitive inhibition binding assay was performed for exemplified peptides according to the invention using membrane homogenates prepared from HEK...


US Patent US9040663 (2015)


BindingDB Entry DOI: 10.7270/Q29885SK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM160217
PNG
(US9040663, 63)
Show SMILES C[C@@H](OCc1ccccc1)[C@@H]1NC(=O)[C@H](CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2Cl)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C55H75ClN16O10/c1-31(82-30-33-13-4-3-5-14-33)46-53(81)71-43(27-34-15-6-8-17-37(34)56)52(80)68-41(21-12-26-64-55(60)61)49(77)70-44(28-35-29-65-38-18-9-7-16-36(35)38)51(79)67-39(47(57)75)19-10-24-62-45(74)23-22-42(50(78)72-46)69-48(76)40(66-32(2)73)20-11-25-63-54(58)59/h3-9,13-18,29,31,39-44,46,65H,10-12,19-28,30H2,1-2H3,(H2,57,75)(H,62,74)(H,66,73)(H,67,79)(H,68,80)(H,69,76)(H,70,77)(H,71,81)(H,72,78)(H4,58,59,63)(H4,60,61,64)/t31-,39+,40+,41+,42+,43-,44+,46+/m1/s1
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0.350 -56.1n/an/an/an/an/a7.537



AstraZeneca AB

US Patent


Assay Description
A competitive inhibition binding assay was performed for exemplified peptides according to the invention using membrane homogenates prepared from HEK...


US Patent US9040663 (2015)


BindingDB Entry DOI: 10.7270/Q29885SK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135752
PNG
(US10179804, Example 137 | US8846601, 137 | US94582...)
Show SMILES NCC[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)C1CCCCC1
Show InChI InChI=1S/C53H79N17O9/c54-23-22-39-48(76)68-40(27-31-13-3-1-4-14-31)49(77)66-38(21-12-26-62-53(58)59)47(75)69-41(28-33-30-63-35-18-8-7-17-34(33)35)50(78)64-36(44(55)72)19-9-10-24-60-43(71)29-42(51(79)67-39)70-46(74)37(20-11-25-61-52(56)57)65-45(73)32-15-5-2-6-16-32/h1,3-4,7-8,13-14,17-18,30,32,36-42,63H,2,5-6,9-12,15-16,19-29,54H2,(H2,55,72)(H,60,71)(H,64,78)(H,65,73)(H,66,77)(H,67,79)(H,68,76)(H,69,75)(H,70,74)(H4,56,57,61)(H4,58,59,62)/t36-,37-,38-,39-,40+,41-,42-/m0/s1
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0.400n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM160173
PNG
(US9040663, 19)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2cccc(C)c2)NC(=O)[C@H](CCN)NC1=O)C(N)=O
Show InChI InChI=1S/C49H73N17O9/c1-27-9-5-10-29(23-27)24-38-46(74)62-35(15-8-22-58-49(54)55)43(71)66-39(25-30-26-59-32-12-4-3-11-31(30)32)47(75)61-33(41(51)69)13-6-20-56-40(68)17-16-36(44(72)64-37(18-19-50)45(73)65-38)63-42(70)34(60-28(2)67)14-7-21-57-48(52)53/h3-5,9-12,23,26,33-39,59H,6-8,13-22,24-25,50H2,1-2H3,(H2,51,69)(H,56,68)(H,60,67)(H,61,75)(H,62,74)(H,63,70)(H,64,72)(H,65,73)(H,66,71)(H4,52,53,57)(H4,54,55,58)/t33-,34-,35-,36-,37-,38+,39-/m0/s1
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0.400 -55.8n/an/an/an/an/a7.537



AstraZeneca AB

US Patent


Assay Description
A competitive inhibition binding assay was performed for exemplified peptides according to the invention using membrane homogenates prepared from HEK...


US Patent US9040663 (2015)


BindingDB Entry DOI: 10.7270/Q29885SK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135752
PNG
(US10179804, Example 137 | US8846601, 137 | US94582...)
Show SMILES NCC[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)C1CCCCC1
Show InChI InChI=1S/C53H79N17O9/c54-23-22-39-48(76)68-40(27-31-13-3-1-4-14-31)49(77)66-38(21-12-26-62-53(58)59)47(75)69-41(28-33-30-63-35-18-8-7-17-34(33)35)50(78)64-36(44(55)72)19-9-10-24-60-43(71)29-42(51(79)67-39)70-46(74)37(20-11-25-61-52(56)57)65-45(73)32-15-5-2-6-16-32/h1,3-4,7-8,13-14,17-18,30,32,36-42,63H,2,5-6,9-12,15-16,19-29,54H2,(H2,55,72)(H,60,71)(H,64,78)(H,65,73)(H,66,77)(H,67,79)(H,68,76)(H,69,75)(H,70,74)(H4,56,57,61)(H4,58,59,62)/t36-,37-,38-,39-,40+,41-,42-/m0/s1
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0.400 -55.8n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135736
PNG
(US10179804, Example 121 | US8846601, 121 | US94582...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCN)NC1=O)C(N)=O
Show InChI InChI=1S/C48H71N17O9/c1-27(66)59-32(16-9-21-56-47(51)52)41(69)60-33-15-7-8-20-55-39(67)25-36(40(50)68)63-46(74)38(24-29-26-58-31-14-6-5-13-30(29)31)65-43(71)34(17-10-22-57-48(53)54)61-45(73)37(23-28-11-3-2-4-12-28)64-44(72)35(18-19-49)62-42(33)70/h2-6,11-14,26,32-38,58H,7-10,15-25,49H2,1H3,(H2,50,68)(H,55,67)(H,59,66)(H,60,69)(H,61,73)(H,62,70)(H,63,74)(H,64,72)(H,65,71)(H4,51,52,56)(H4,53,54,57)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
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0.400 -55.8n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135736
PNG
(US10179804, Example 121 | US8846601, 121 | US94582...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCN)NC1=O)C(N)=O
Show InChI InChI=1S/C48H71N17O9/c1-27(66)59-32(16-9-21-56-47(51)52)41(69)60-33-15-7-8-20-55-39(67)25-36(40(50)68)63-46(74)38(24-29-26-58-31-14-6-5-13-30(29)31)65-43(71)34(17-10-22-57-48(53)54)61-45(73)37(23-28-11-3-2-4-12-28)64-44(72)35(18-19-49)62-42(33)70/h2-6,11-14,26,32-38,58H,7-10,15-25,49H2,1H3,(H2,50,68)(H,55,67)(H,59,66)(H,60,69)(H,61,73)(H,62,70)(H,63,74)(H,64,72)(H,65,71)(H4,51,52,56)(H4,53,54,57)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
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0.400n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM160178
PNG
(US9040663, 24)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccc(cc2)[N+]([O-])=O)NC(=O)[C@H](CCN)NC1=O)C(N)=O
Show InChI InChI=1S/C48H70N18O11/c1-26(67)59-33(10-5-21-56-47(51)52)41(70)62-35-16-17-39(68)55-20-4-9-32(40(50)69)60-46(75)38(24-28-25-58-31-8-3-2-7-30(28)31)65-42(71)34(11-6-22-57-48(53)54)61-45(74)37(23-27-12-14-29(15-13-27)66(76)77)64-44(73)36(18-19-49)63-43(35)72/h2-3,7-8,12-15,25,32-38,58H,4-6,9-11,16-24,49H2,1H3,(H2,50,69)(H,55,68)(H,59,67)(H,60,75)(H,61,74)(H,62,70)(H,63,72)(H,64,73)(H,65,71)(H4,51,52,56)(H4,53,54,57)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
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0.450 -55.5n/an/an/an/an/a7.537



AstraZeneca AB

US Patent


Assay Description
A competitive inhibition binding assay was performed for exemplified peptides according to the invention using membrane homogenates prepared from HEK...


US Patent US9040663 (2015)


BindingDB Entry DOI: 10.7270/Q29885SK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM160172
PNG
(US9040663, 18)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2C)NC(=O)[C@H](CCN)NC1=O)C(N)=O
Show InChI InChI=1S/C49H73N17O9/c1-27-10-3-4-11-29(27)24-38-47(75)62-35(16-9-23-58-49(54)55)43(71)66-39(25-30-26-59-32-13-6-5-12-31(30)32)46(74)61-33(41(51)69)14-7-21-56-40(68)18-17-36(44(72)64-37(19-20-50)45(73)65-38)63-42(70)34(60-28(2)67)15-8-22-57-48(52)53/h3-6,10-13,26,33-39,59H,7-9,14-25,50H2,1-2H3,(H2,51,69)(H,56,68)(H,60,67)(H,61,74)(H,62,75)(H,63,70)(H,64,72)(H,65,73)(H,66,71)(H4,52,53,57)(H4,54,55,58)/t33-,34-,35-,36-,37-,38+,39-/m0/s1
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0.5 -55.2n/an/an/an/an/a7.537



AstraZeneca AB

US Patent


Assay Description
A competitive inhibition binding assay was performed for exemplified peptides according to the invention using membrane homogenates prepared from HEK...


US Patent US9040663 (2015)


BindingDB Entry DOI: 10.7270/Q29885SK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM160253
PNG
(US9040663, 99)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2cccc(Cl)c2)NC(=O)[C@H](CCCNC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C50H73ClN18O10/c1-27(70)63-34(14-6-20-59-48(53)54)42(73)67-37-17-18-40(71)58-19-5-13-33(41(52)72)64-47(78)39(25-29-26-62-32-12-3-2-11-31(29)32)69-44(75)36(15-7-21-60-49(55)56)66-46(77)38(24-28-9-4-10-30(51)23-28)68-43(74)35(65-45(37)76)16-8-22-61-50(57)79/h2-4,9-12,23,26,33-39,62H,5-8,13-22,24-25H2,1H3,(H2,52,72)(H,58,71)(H,63,70)(H,64,78)(H,65,76)(H,66,77)(H,67,73)(H,68,74)(H,69,75)(H4,53,54,59)(H4,55,56,60)(H3,57,61,79)/t33-,34-,35-,36-,37-,38+,39-/m0/s1
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0.5 -55.2n/an/an/an/an/a7.537



AstraZeneca AB

US Patent


Assay Description
A competitive inhibition binding assay was performed for exemplified peptides according to the invention using membrane homogenates prepared from HEK...


US Patent US9040663 (2015)


BindingDB Entry DOI: 10.7270/Q29885SK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM160183
PNG
(US9040663, 29)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccc(cc2)-c2ccccc2)NC(=O)[C@H](CCN)NC1=O)C(N)=O
Show InChI InChI=1S/C54H75N17O9/c1-31(72)65-39(15-8-26-62-53(57)58)47(75)68-41-21-22-45(73)61-25-7-14-38(46(56)74)66-52(80)44(29-35-30-64-37-13-6-5-12-36(35)37)71-48(76)40(16-9-27-63-54(59)60)67-51(79)43(70-50(78)42(23-24-55)69-49(41)77)28-32-17-19-34(20-18-32)33-10-3-2-4-11-33/h2-6,10-13,17-20,30,38-44,64H,7-9,14-16,21-29,55H2,1H3,(H2,56,74)(H,61,73)(H,65,72)(H,66,80)(H,67,79)(H,68,75)(H,69,77)(H,70,78)(H,71,76)(H4,57,58,62)(H4,59,60,63)/t38-,39-,40-,41-,42-,43+,44-/m0/s1
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0.5 -55.2n/an/an/an/an/a7.537



AstraZeneca AB

US Patent


Assay Description
A competitive inhibition binding assay was performed for exemplified peptides according to the invention using membrane homogenates prepared from HEK...


US Patent US9040663 (2015)


BindingDB Entry DOI: 10.7270/Q29885SK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM160206
PNG
(US9040663, 52)
Show SMILES CC(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccc(cc2)C#N)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C51H69N19O9/c1-28(71)64-36(9-5-19-60-50(54)55)44(74)66-37-10-4-18-59-42(72)17-16-35(43(53)73)65-48(78)40(22-31-25-62-34-8-3-2-7-33(31)34)69-45(75)38(11-6-20-61-51(56)57)67-47(77)39(21-29-12-14-30(24-52)15-13-29)68-49(79)41(70-46(37)76)23-32-26-58-27-63-32/h2-3,7-8,12-15,25-27,35-41,62H,4-6,9-11,16-23H2,1H3,(H2,53,73)(H,58,63)(H,59,72)(H,64,71)(H,65,78)(H,66,74)(H,67,77)(H,68,79)(H,69,75)(H,70,76)(H4,54,55,60)(H4,56,57,61)/t35-,36+,37-,38-,39+,40-,41-/m0/s1
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0.600 -54.8n/an/an/an/an/a7.537



AstraZeneca AB

US Patent


Assay Description
A competitive inhibition binding assay was performed for exemplified peptides according to the invention using membrane homogenates prepared from HEK...


US Patent US9040663 (2015)


BindingDB Entry DOI: 10.7270/Q29885SK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM160205
PNG
(US9040663, 51)
Show SMILES CC(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2cccc(Cl)c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H69ClN18O9/c1-27(70)63-35(12-6-18-59-49(53)54)43(73)65-36-13-5-17-58-41(71)16-15-34(42(52)72)64-47(77)39(22-29-24-61-33-11-3-2-10-32(29)33)68-44(74)37(14-7-19-60-50(55)56)66-46(76)38(21-28-8-4-9-30(51)20-28)67-48(78)40(69-45(36)75)23-31-25-57-26-62-31/h2-4,8-11,20,24-26,34-40,61H,5-7,12-19,21-23H2,1H3,(H2,52,72)(H,57,62)(H,58,71)(H,63,70)(H,64,77)(H,65,73)(H,66,76)(H,67,78)(H,68,74)(H,69,75)(H4,53,54,59)(H4,55,56,60)/t34-,35+,36-,37-,38+,39-,40-/m0/s1
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0.600 -54.8n/an/an/an/an/a7.537



AstraZeneca AB

US Patent


Assay Description
A competitive inhibition binding assay was performed for exemplified peptides according to the invention using membrane homogenates prepared from HEK...


US Patent US9040663 (2015)


BindingDB Entry DOI: 10.7270/Q29885SK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM160167
PNG
(US9040663, 13)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2C(F)(F)F)NC(=O)[C@H](CCN)NC1=O)C(N)=O
Show InChI InChI=1S/C49H70F3N17O9/c1-26(70)63-33(14-7-21-60-47(55)56)41(73)66-35-16-17-39(71)59-20-6-13-32(40(54)72)64-45(77)38(24-28-25-62-31-12-5-3-10-29(28)31)69-42(74)34(15-8-22-61-48(57)58)65-46(78)37(68-44(76)36(18-19-53)67-43(35)75)23-27-9-2-4-11-30(27)49(50,51)52/h2-5,9-12,25,32-38,62H,6-8,13-24,53H2,1H3,(H2,54,72)(H,59,71)(H,63,70)(H,64,77)(H,65,78)(H,66,73)(H,67,75)(H,68,76)(H,69,74)(H4,55,56,60)(H4,57,58,61)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
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0.600 -54.8n/an/an/an/an/a7.537



AstraZeneca AB

US Patent


Assay Description
A competitive inhibition binding assay was performed for exemplified peptides according to the invention using membrane homogenates prepared from HEK...


US Patent US9040663 (2015)


BindingDB Entry DOI: 10.7270/Q29885SK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135690
PNG
(US10179804, Example 75 | US8846601, 75 | US9458201...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H70N18O9/c1-28(69)62-35(14-8-20-58-49(52)53)43(72)64-36-15-7-19-57-41(70)18-17-34(42(51)71)63-47(76)39(23-30-25-60-33-13-6-5-12-32(30)33)67-44(73)37(16-9-21-59-50(54)55)65-46(75)38(22-29-10-3-2-4-11-29)66-48(77)40(68-45(36)74)24-31-26-56-27-61-31/h2-6,10-13,25-27,34-40,60H,7-9,14-24H2,1H3,(H2,51,71)(H,56,61)(H,57,70)(H,62,69)(H,63,76)(H,64,72)(H,65,75)(H,66,77)(H,67,73)(H,68,74)(H4,52,53,58)(H4,54,55,59)/t34-,35-,36-,37-,38+,39-,40-/m0/s1
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0.600n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135690
PNG
(US10179804, Example 75 | US8846601, 75 | US9458201...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H70N18O9/c1-28(69)62-35(14-8-20-58-49(52)53)43(72)64-36-15-7-19-57-41(70)18-17-34(42(51)71)63-47(76)39(23-30-25-60-33-13-6-5-12-32(30)33)67-44(73)37(16-9-21-59-50(54)55)65-46(75)38(22-29-10-3-2-4-11-29)66-48(77)40(68-45(36)74)24-31-26-56-27-61-31/h2-6,10-13,25-27,34-40,60H,7-9,14-24H2,1H3,(H2,51,71)(H,56,61)(H,57,70)(H,62,69)(H,63,76)(H,64,72)(H,65,75)(H,66,77)(H,67,73)(H,68,74)(H4,52,53,58)(H4,54,55,59)/t34-,35-,36-,37-,38+,39-,40-/m0/s1
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0.600 -54.8n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM160211
PNG
(US9040663, 57)
Show SMILES CC(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H69FN18O9/c1-27(70)63-35(9-5-19-59-49(53)54)43(73)65-36-10-4-18-58-41(71)17-16-34(42(52)72)64-47(77)39(22-29-24-61-33-8-3-2-7-32(29)33)68-44(74)37(11-6-20-60-50(55)56)66-46(76)38(21-28-12-14-30(51)15-13-28)67-48(78)40(69-45(36)75)23-31-25-57-26-62-31/h2-3,7-8,12-15,24-26,34-40,61H,4-6,9-11,16-23H2,1H3,(H2,52,72)(H,57,62)(H,58,71)(H,63,70)(H,64,77)(H,65,73)(H,66,76)(H,67,78)(H,68,74)(H,69,75)(H4,53,54,59)(H4,55,56,60)/t34-,35+,36-,37-,38+,39-,40-/m0/s1
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0.650 -54.5n/an/an/an/an/a7.537



AstraZeneca AB

US Patent


Assay Description
A competitive inhibition binding assay was performed for exemplified peptides according to the invention using membrane homogenates prepared from HEK...


US Patent US9040663 (2015)


BindingDB Entry DOI: 10.7270/Q29885SK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM160181
PNG
(US9040663, 27)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2cc(F)c(F)c(F)c2)NC(=O)[C@H](CCN)NC1=O)C(N)=O
Show InChI InChI=1S/C48H68F3N17O9/c1-24(69)62-32(10-5-17-59-47(54)55)41(72)65-34-12-13-38(70)58-16-4-9-31(40(53)71)63-46(77)37(22-26-23-61-30-8-3-2-7-27(26)30)68-42(73)33(11-6-18-60-48(56)57)64-45(76)36(21-25-19-28(49)39(51)29(50)20-25)67-44(75)35(14-15-52)66-43(34)74/h2-3,7-8,19-20,23,31-37,61H,4-6,9-18,21-22,52H2,1H3,(H2,53,71)(H,58,70)(H,62,69)(H,63,77)(H,64,76)(H,65,72)(H,66,74)(H,67,75)(H,68,73)(H4,54,55,59)(H4,56,57,60)/t31-,32-,33-,34-,35-,36+,37-/m0/s1
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0.667 -54.5n/an/an/an/an/a7.537



AstraZeneca AB

US Patent


Assay Description
A competitive inhibition binding assay was performed for exemplified peptides according to the invention using membrane homogenates prepared from HEK...


US Patent US9040663 (2015)


BindingDB Entry DOI: 10.7270/Q29885SK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135717
PNG
(US10179804, Example 102 | US8846601, 102 | US94582...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC1=O)C(N)=O
Show InChI InChI=1S/C50H75N19O9/c1-28(70)63-34(16-8-22-59-48(52)53)42(73)67-37-19-20-40(71)58-21-7-15-33(41(51)72)64-47(78)39(26-30-27-62-32-14-6-5-13-31(30)32)69-44(75)36(18-10-24-61-50(56)57)66-46(77)38(25-29-11-3-2-4-12-29)68-43(74)35(65-45(37)76)17-9-23-60-49(54)55/h2-6,11-14,27,33-39,62H,7-10,15-26H2,1H3,(H2,51,72)(H,58,71)(H,63,70)(H,64,78)(H,65,76)(H,66,77)(H,67,73)(H,68,74)(H,69,75)(H4,52,53,59)(H4,54,55,60)(H4,56,57,61)/t33-,34-,35-,36-,37-,38+,39-/m0/s1
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0.700 -54.4n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135717
PNG
(US10179804, Example 102 | US8846601, 102 | US94582...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC1=O)C(N)=O
Show InChI InChI=1S/C50H75N19O9/c1-28(70)63-34(16-8-22-59-48(52)53)42(73)67-37-19-20-40(71)58-21-7-15-33(41(51)72)64-47(78)39(26-30-27-62-32-14-6-5-13-31(30)32)69-44(75)36(18-10-24-61-50(56)57)66-46(77)38(25-29-11-3-2-4-12-29)68-43(74)35(65-45(37)76)17-9-23-60-49(54)55/h2-6,11-14,27,33-39,62H,7-10,15-26H2,1H3,(H2,51,72)(H,58,71)(H,63,70)(H,64,78)(H,65,76)(H,66,77)(H,67,73)(H,68,74)(H,69,75)(H4,52,53,59)(H4,54,55,60)(H4,56,57,61)/t33-,34-,35-,36-,37-,38+,39-/m0/s1
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0.700n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135630
PNG
(US10179804, Example 15 | US8846601, 15 | US9458201...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@H](CN2C1=O)OCc1ccccc1)C(N)=O
Show InChI InChI=1S/C56H76N16O10/c1-33(73)66-41(21-12-24-63-55(58)59)49(76)71-45-29-47(74)62-23-11-10-20-40(48(57)75)67-52(79)44(27-36-30-65-39-19-9-8-18-38(36)39)69-50(77)42(22-13-25-64-56(60)61)68-51(78)43(26-34-14-4-2-5-15-34)70-53(80)46-28-37(31-72(46)54(45)81)82-32-35-16-6-3-7-17-35/h2-9,14-19,30,37,40-46,65H,10-13,20-29,31-32H2,1H3,(H2,57,75)(H,62,74)(H,66,73)(H,67,79)(H,68,78)(H,69,77)(H,70,80)(H,71,76)(H4,58,59,63)(H4,60,61,64)/t37-,40+,41+,42+,43-,44+,45+,46+/m1/s1
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0.700n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM160177
PNG
(US9040663, 23)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2cccc(c2)[N+]([O-])=O)NC(=O)[C@H](CCN)NC1=O)C(N)=O
Show InChI InChI=1S/C48H70N18O11/c1-26(67)59-33(13-6-20-56-47(51)52)41(70)62-35-15-16-39(68)55-19-5-12-32(40(50)69)60-46(75)38(24-28-25-58-31-11-3-2-10-30(28)31)65-42(71)34(14-7-21-57-48(53)54)61-45(74)37(23-27-8-4-9-29(22-27)66(76)77)64-44(73)36(17-18-49)63-43(35)72/h2-4,8-11,22,25,32-38,58H,5-7,12-21,23-24,49H2,1H3,(H2,50,69)(H,55,68)(H,59,67)(H,60,75)(H,61,74)(H,62,70)(H,63,72)(H,64,73)(H,65,71)(H4,51,52,56)(H4,53,54,57)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
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0.700 -54.4n/an/an/an/an/a7.537



AstraZeneca AB

US Patent


Assay Description
A competitive inhibition binding assay was performed for exemplified peptides according to the invention using membrane homogenates prepared from HEK...


US Patent US9040663 (2015)


BindingDB Entry DOI: 10.7270/Q29885SK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM160163
PNG
(US9040663, 9)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2F)NC(=O)[C@H](CCN)NC1=O)C(N)=O
Show InChI InChI=1S/C48H70FN17O9/c1-26(67)60-33(14-7-21-57-47(52)53)41(70)63-35-16-17-39(68)56-20-6-13-32(40(51)69)61-45(74)38(24-28-25-59-31-12-5-3-10-29(28)31)66-42(71)34(15-8-22-58-48(54)55)62-46(75)37(23-27-9-2-4-11-30(27)49)65-44(73)36(18-19-50)64-43(35)72/h2-5,9-12,25,32-38,59H,6-8,13-24,50H2,1H3,(H2,51,69)(H,56,68)(H,60,67)(H,61,74)(H,62,75)(H,63,70)(H,64,72)(H,65,73)(H,66,71)(H4,52,53,57)(H4,54,55,58)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
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0.700 -54.4n/an/an/an/an/a7.537



AstraZeneca AB

US Patent


Assay Description
A competitive inhibition binding assay was performed for exemplified peptides according to the invention using membrane homogenates prepared from HEK...


US Patent US9040663 (2015)


BindingDB Entry DOI: 10.7270/Q29885SK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM160156
PNG
(US9040663, 2)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2cccc(Cl)c2)NC(=O)[C@H](CCN)NC1=O)C(N)=O
Show InChI InChI=1S/C48H70ClN17O9/c1-26(67)60-33(13-6-20-57-47(52)53)41(70)63-35-15-16-39(68)56-19-5-12-32(40(51)69)61-46(75)38(24-28-25-59-31-11-3-2-10-30(28)31)66-42(71)34(14-7-21-58-48(54)55)62-45(74)37(23-27-8-4-9-29(49)22-27)65-44(73)36(17-18-50)64-43(35)72/h2-4,8-11,22,25,32-38,59H,5-7,12-21,23-24,50H2,1H3,(H2,51,69)(H,56,68)(H,60,67)(H,61,75)(H,62,74)(H,63,70)(H,64,72)(H,65,73)(H,66,71)(H4,52,53,57)(H4,54,55,58)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
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0.75 -54.2n/an/an/an/an/a7.537



AstraZeneca AB

US Patent


Assay Description
A competitive inhibition binding assay was performed for exemplified peptides according to the invention using membrane homogenates prepared from HEK...


US Patent US9040663 (2015)


BindingDB Entry DOI: 10.7270/Q29885SK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM160252
PNG
(US9040663, 98)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2cc(F)c(F)c(F)c2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C49H68F3N17O10/c1-24(70)63-32(9-5-17-60-48(55)56)42(74)65-33-10-4-16-59-39(72)15-13-31(41(54)73)64-47(79)37(22-26-23-62-30-8-3-2-7-27(26)30)69-44(76)34(11-6-18-61-49(57)58)66-46(78)36(21-25-19-28(50)40(52)29(51)20-25)68-45(77)35(67-43(33)75)12-14-38(53)71/h2-3,7-8,19-20,23,31-37,62H,4-6,9-18,21-22H2,1H3,(H2,53,71)(H2,54,73)(H,59,72)(H,63,70)(H,64,79)(H,65,74)(H,66,78)(H,67,75)(H,68,77)(H,69,76)(H4,55,56,60)(H4,57,58,61)/t31-,32-,33-,34-,35-,36+,37-/m0/s1
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0.75 -54.2n/an/an/an/an/a7.537



AstraZeneca AB

US Patent


Assay Description
A competitive inhibition binding assay was performed for exemplified peptides according to the invention using membrane homogenates prepared from HEK...


US Patent US9040663 (2015)


BindingDB Entry DOI: 10.7270/Q29885SK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM160251
PNG
(US9040663, 97)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2cc(F)c(F)c(F)c2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(O)=O
Show InChI InChI=1S/C49H67F3N16O11/c1-24(69)62-31(9-4-17-59-48(54)55)41(72)65-34-13-15-39(71)58-16-6-11-35(47(78)79)66-46(77)37(22-26-23-61-30-8-3-2-7-27(26)30)68-42(73)32(10-5-18-60-49(56)57)63-45(76)36(21-25-19-28(50)40(52)29(51)20-25)67-44(75)33(64-43(34)74)12-14-38(53)70/h2-3,7-8,19-20,23,31-37,61H,4-6,9-18,21-22H2,1H3,(H2,53,70)(H,58,71)(H,62,69)(H,63,76)(H,64,74)(H,65,72)(H,66,77)(H,67,75)(H,68,73)(H,78,79)(H4,54,55,59)(H4,56,57,60)/t31-,32-,33-,34-,35-,36+,37-/m0/s1
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0.75 -54.2n/an/an/an/an/a7.537



AstraZeneca AB

US Patent


Assay Description
A competitive inhibition binding assay was performed for exemplified peptides according to the invention using membrane homogenates prepared from HEK...


US Patent US9040663 (2015)


BindingDB Entry DOI: 10.7270/Q29885SK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM250661
PNG
(US9447148, 9.30)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCC(=O)NCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O
Show InChI InChI=1S/C51H68N14O9/c1-3-4-18-36(59-30(2)66)45(69)61-38-20-21-43(67)56-24-22-39(48(72)63-40(44(52)68)26-33-16-10-15-32-14-8-9-17-35(32)33)62-46(70)37(19-11-23-57-51(53)54)60-49(73)41(25-31-12-6-5-7-13-31)64-50(74)42(65-47(38)71)27-34-28-55-29-58-34/h5-10,12-17,28-29,36-42H,3-4,11,18-27H2,1-2H3,(H2,52,68)(H,55,58)(H,56,67)(H,59,66)(H,60,73)(H,61,69)(H,62,70)(H,63,72)(H,64,74)(H,65,71)(H4,53,54,57)/t36-,37-,38-,39-,40-,41+,42-/m0/s1
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0.75 -54.2n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMCR-1a or hMCR-...


US Patent US9447148 (2016)


BindingDB Entry DOI: 10.7270/Q2RJ4HD2
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135753
PNG
(US10179804, Example 138 | US8846601, 138 | US94582...)
Show SMILES NCC[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CC1CCCC1
Show InChI InChI=1S/C53H79N17O9/c54-22-21-39-48(76)68-40(26-31-12-2-1-3-13-31)49(77)66-38(20-11-25-62-53(58)59)47(75)69-41(28-33-30-63-35-17-7-6-16-34(33)35)50(78)65-36(45(55)73)18-8-9-23-60-43(71)29-42(51(79)67-39)70-46(74)37(19-10-24-61-52(56)57)64-44(72)27-32-14-4-5-15-32/h1-3,6-7,12-13,16-17,30,32,36-42,63H,4-5,8-11,14-15,18-29,54H2,(H2,55,73)(H,60,71)(H,64,72)(H,65,78)(H,66,77)(H,67,79)(H,68,76)(H,69,75)(H,70,74)(H4,56,57,61)(H4,58,59,62)/t36-,37-,38-,39-,40+,41-,42-/m0/s1
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0.800n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135753
PNG
(US10179804, Example 138 | US8846601, 138 | US94582...)
Show SMILES NCC[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CC1CCCC1
Show InChI InChI=1S/C53H79N17O9/c54-22-21-39-48(76)68-40(26-31-12-2-1-3-13-31)49(77)66-38(20-11-25-62-53(58)59)47(75)69-41(28-33-30-63-35-17-7-6-16-34(33)35)50(78)65-36(45(55)73)18-8-9-23-60-43(71)29-42(51(79)67-39)70-46(74)37(19-10-24-61-52(56)57)64-44(72)27-32-14-4-5-15-32/h1-3,6-7,12-13,16-17,30,32,36-42,63H,4-5,8-11,14-15,18-29,54H2,(H2,55,73)(H,60,71)(H,64,72)(H,65,78)(H,66,77)(H,67,79)(H,68,76)(H,69,75)(H,70,74)(H4,56,57,61)(H4,58,59,62)/t36-,37-,38-,39-,40+,41-,42-/m0/s1
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0.800 -54.0n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM160161
PNG
(US9040663, 7)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccc(cc2)C#N)NC(=O)[C@H](CCN)NC1=O)C(N)=O
Show InChI InChI=1S/C49H70N18O9/c1-27(68)61-34(10-5-21-58-48(53)54)42(71)64-36-16-17-40(69)57-20-4-9-33(41(52)70)62-47(76)39(24-30-26-60-32-8-3-2-7-31(30)32)67-43(72)35(11-6-22-59-49(55)56)63-46(75)38(23-28-12-14-29(25-51)15-13-28)66-45(74)37(18-19-50)65-44(36)73/h2-3,7-8,12-15,26,33-39,60H,4-6,9-11,16-24,50H2,1H3,(H2,52,70)(H,57,69)(H,61,68)(H,62,76)(H,63,75)(H,64,71)(H,65,73)(H,66,74)(H,67,72)(H4,53,54,58)(H4,55,56,59)/t33-,34-,35-,36-,37-,38+,39-/m0/s1
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0.833 -53.9n/an/an/an/an/a7.537



AstraZeneca AB

US Patent


Assay Description
A competitive inhibition binding assay was performed for exemplified peptides according to the invention using membrane homogenates prepared from HEK...


US Patent US9040663 (2015)


BindingDB Entry DOI: 10.7270/Q29885SK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM160248
PNG
(US9040663, 94)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccc(cc2)C#N)NC(=O)[C@H](CCC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C50H70N18O10/c1-27(69)62-34(9-5-21-59-49(54)55)43(73)64-35-10-4-20-58-41(71)19-17-33(42(53)72)63-48(78)39(24-30-26-61-32-8-3-2-7-31(30)32)68-45(75)36(11-6-22-60-50(56)57)65-47(77)38(23-28-12-14-29(25-51)15-13-28)67-46(76)37(66-44(35)74)16-18-40(52)70/h2-3,7-8,12-15,26,33-39,61H,4-6,9-11,16-24H2,1H3,(H2,52,70)(H2,53,72)(H,58,71)(H,62,69)(H,63,78)(H,64,73)(H,65,77)(H,66,74)(H,67,76)(H,68,75)(H4,54,55,59)(H4,56,57,60)/t33-,34-,35-,36-,37-,38+,39-/m0/s1
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0.900 -53.7n/an/an/an/an/a7.537



AstraZeneca AB

US Patent


Assay Description
A competitive inhibition binding assay was performed for exemplified peptides according to the invention using membrane homogenates prepared from HEK...


US Patent US9040663 (2015)


BindingDB Entry DOI: 10.7270/Q29885SK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM160207
PNG
(US9040663, 53)
Show SMILES CC(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2F)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H69FN18O9/c1-27(70)63-35(13-7-19-59-49(53)54)43(73)65-36-14-6-18-58-41(71)17-16-34(42(52)72)64-46(76)39(22-29-24-61-33-12-5-3-10-31(29)33)67-44(74)37(15-8-20-60-50(55)56)66-47(77)38(21-28-9-2-4-11-32(28)51)68-48(78)40(69-45(36)75)23-30-25-57-26-62-30/h2-5,9-12,24-26,34-40,61H,6-8,13-23H2,1H3,(H2,52,72)(H,57,62)(H,58,71)(H,63,70)(H,64,76)(H,65,73)(H,66,77)(H,67,74)(H,68,78)(H,69,75)(H4,53,54,59)(H4,55,56,60)/t34-,35+,36-,37-,38+,39-,40-/m0/s1
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0.950 -53.6n/an/an/an/an/a7.537



AstraZeneca AB

US Patent


Assay Description
A competitive inhibition binding assay was performed for exemplified peptides according to the invention using membrane homogenates prepared from HEK...


US Patent US9040663 (2015)


BindingDB Entry DOI: 10.7270/Q29885SK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM160168
PNG
(US9040663, 14)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2cccc(c2)C(F)(F)F)NC(=O)[C@H](CCN)NC1=O)C(N)=O
Show InChI InChI=1S/C49H70F3N17O9/c1-26(70)63-33(13-6-20-60-47(55)56)41(73)66-35-15-16-39(71)59-19-5-12-32(40(54)72)64-46(78)38(24-28-25-62-31-11-3-2-10-30(28)31)69-42(74)34(14-7-21-61-48(57)58)65-45(77)37(68-44(76)36(17-18-53)67-43(35)75)23-27-8-4-9-29(22-27)49(50,51)52/h2-4,8-11,22,25,32-38,62H,5-7,12-21,23-24,53H2,1H3,(H2,54,72)(H,59,71)(H,63,70)(H,64,78)(H,65,77)(H,66,73)(H,67,75)(H,68,76)(H,69,74)(H4,55,56,60)(H4,57,58,61)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
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0.950 -53.6n/an/an/an/an/a7.537



AstraZeneca AB

US Patent


Assay Description
A competitive inhibition binding assay was performed for exemplified peptides according to the invention using membrane homogenates prepared from HEK...


US Patent US9040663 (2015)


BindingDB Entry DOI: 10.7270/Q29885SK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135629
PNG
(US10179804, Example 14 | US8846601, 14 | US9458201...)
Show SMILES C[C@@H](OCc1ccccc1)[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C55H76N16O10/c1-32(81-31-35-17-7-4-8-18-35)46-53(80)70-42(27-34-15-5-3-6-16-34)50(77)67-41(23-14-26-63-55(59)60)49(76)68-43(28-36-30-64-38-20-10-9-19-37(36)38)51(78)66-39(47(56)74)21-11-12-24-61-45(73)29-44(52(79)71-46)69-48(75)40(65-33(2)72)22-13-25-62-54(57)58/h3-10,15-20,30,32,39-44,46,64H,11-14,21-29,31H2,1-2H3,(H2,56,74)(H,61,73)(H,65,72)(H,66,78)(H,67,77)(H,68,76)(H,69,75)(H,70,80)(H,71,79)(H4,57,58,62)(H4,59,60,63)/t32-,39+,40+,41+,42-,43+,44+,46+/m1/s1
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1 -53.4n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135754
PNG
(US10179804, Example 139 | US8846601, 139 | US94582...)
Show SMILES NCC[C@@H]1NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CC1CCCCC1
Show InChI InChI=1S/C54H81N17O9/c55-23-22-40-49(77)69-41(27-32-13-3-1-4-14-32)50(78)67-39(21-12-26-63-54(59)60)48(76)70-42(29-34-31-64-36-18-8-7-17-35(34)36)51(79)66-37(46(56)74)19-9-10-24-61-44(72)30-43(52(80)68-40)71-47(75)38(20-11-25-62-53(57)58)65-45(73)28-33-15-5-2-6-16-33/h1,3-4,7-8,13-14,17-18,31,33,37-43,64H,2,5-6,9-12,15-16,19-30,55H2,(H2,56,74)(H,61,72)(H,65,73)(H,66,79)(H,67,78)(H,68,80)(H,69,77)(H,70,76)(H,71,75)(H4,57,58,62)(H4,59,60,63)/t37-,38-,39-,40-,41+,42-,43-/m0/s1
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Similars

US Patent
1 -53.4n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
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