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Found 3135 hits Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 2'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160763
PNG
(US9682980, 8-Chloro-7-(4-(2-chlorophenyl)piperidin...)
Show SMILES Clc1ccccc1C1CCN(CC1)c1cnn2c(CC3CC3)nnc2c1Cl
Show InChI InChI=1S/C20H21Cl2N5/c21-16-4-2-1-3-15(16)14-7-9-26(10-8-14)17-12-23-27-18(11-13-5-6-13)24-25-20(27)19(17)22/h1-4,12-14H,5-11H2
PDB

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n/an/an/an/a 45n/an/a7.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160764
PNG
(US9682980, 8-Chloro-7-(4-(2-chlorophenyl)piperidin...)
Show SMILES FC(F)(F)Cc1nnc2c(Cl)c(cnn12)N1CCC(CC1)c1ccccc1Cl
Show InChI InChI=1S/C18H16Cl2F3N5/c19-13-4-2-1-3-12(13)11-5-7-27(8-6-11)14-10-24-28-15(9-18(21,22)23)25-26-17(28)16(14)20/h1-4,10-11H,5-9H2
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n/an/an/an/a 48n/an/a7.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160765
PNG
(US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-(2,...)
Show SMILES Clc1cccc(C2CCN(CC2)c2cnn3c(CC4CC4)nnc3c2Cl)c1Cl
Show InChI InChI=1S/C20H20Cl3N5/c21-15-3-1-2-14(18(15)22)13-6-8-27(9-7-13)16-11-24-28-17(10-12-4-5-12)25-26-20(28)19(16)23/h1-3,11-13H,4-10H2
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n/an/an/an/a 154n/an/a7.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160767
PNG
(US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-(3,...)
Show SMILES Clc1cc(Cl)cc(c1)C1CCN(CC1)c1cnn2c(CC3CC3)nnc2c1Cl
Show InChI InChI=1S/C20H20Cl3N5/c21-15-8-14(9-16(22)10-15)13-3-5-27(6-4-13)17-11-24-28-18(7-12-1-2-12)25-26-20(28)19(17)23/h8-13H,1-7H2
PDB

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n/an/an/an/a 144n/an/a7.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160768
PNG
(US9682980, 8-Chloro-7-(4-(3,5-dichlorophenyl)piper...)
Show SMILES FC(F)(F)Cc1nnc2c(Cl)c(cnn12)N1CCC(CC1)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C18H15Cl3F3N5/c19-12-5-11(6-13(20)7-12)10-1-3-28(4-2-10)14-9-25-29-15(8-18(22,23)24)26-27-17(29)16(14)21/h5-7,9-10H,1-4,8H2
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Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160771
PNG
(US9682980, 8-Chloro-3-(cyclopropylmethyl)-N-ethyl-...)
Show SMILES CCN(CC1CC1c1ccc(F)cc1)c1cnn2c(CC3CC3)nnc2c1Cl
Show InChI InChI=1S/C21H23ClFN5/c1-2-27(12-15-10-17(15)14-5-7-16(23)8-6-14)18-11-24-28-19(9-13-3-4-13)25-26-21(28)20(18)22/h5-8,11,13,15,17H,2-4,9-10,12H2,1H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160772
PNG
(US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-(2-...)
Show SMILES FC(F)Oc1c(F)ccc(F)c1C1CCN(CC1)c1cnn2c(CC3CC3)nnc2c1Cl
Show InChI InChI=1S/C21H20ClF4N5O/c22-18-15(10-27-31-16(9-11-1-2-11)28-29-20(18)31)30-7-5-12(6-8-30)17-13(23)3-4-14(24)19(17)32-21(25)26/h3-4,10-12,21H,1-2,5-9H2
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Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160773
PNG
(US9682980, 8-Chloro-7-(4-(2-(difluoromethoxy)-3,6-...)
Show SMILES FC(F)Oc1c(F)ccc(F)c1C1CCN(CC1)c1cnn2c(CC(F)(F)F)nnc2c1Cl
Show InChI InChI=1S/C19H15ClF7N5O/c20-15-12(8-28-32-13(7-19(25,26)27)29-30-17(15)32)31-5-3-9(4-6-31)14-10(21)1-2-11(22)16(14)33-18(23)24/h1-2,8-9,18H,3-7H2
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Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160774
PNG
(US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-(2-...)
Show SMILES FC(F)Oc1cc(F)c(F)cc1C1CCN(CC1)c1cnn2c(CC3CC3)nnc2c1Cl
Show InChI InChI=1S/C21H20ClF4N5O/c22-19-16(10-27-31-18(7-11-1-2-11)28-29-20(19)31)30-5-3-12(4-6-30)13-8-14(23)15(24)9-17(13)32-21(25)26/h8-12,21H,1-7H2
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Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160775
PNG
(US9682980, 8-Chloro-7-(4-(2-(difluoromethoxy)-4,5-...)
Show SMILES FC(F)Oc1cc(F)c(F)cc1C1CCN(CC1)c1cnn2c(CC(F)(F)F)nnc2c1Cl
Show InChI InChI=1S/C19H15ClF7N5O/c20-16-13(8-28-32-15(7-19(25,26)27)29-30-17(16)32)31-3-1-9(2-4-31)10-5-11(21)12(22)6-14(10)33-18(23)24/h5-6,8-9,18H,1-4,7H2
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Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160776
PNG
(US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-(2-...)
Show SMILES FC(F)Oc1c(F)cc(F)cc1C1CCN(CC1)c1cnn2c(CC3CC3)nnc2c1Cl
Show InChI InChI=1S/C21H20ClF4N5O/c22-18-16(10-27-31-17(7-11-1-2-11)28-29-20(18)31)30-5-3-12(4-6-30)14-8-13(23)9-15(24)19(14)32-21(25)26/h8-12,21H,1-7H2
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Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160777
PNG
(US9682980, 8-Chloro-7-(4-(2-(difluoromethoxy)-3,5-...)
Show SMILES FC(F)Oc1c(F)cc(F)cc1C1CCN(CC1)c1cnn2c(CC(F)(F)F)nnc2c1Cl
Show InChI InChI=1S/C19H15ClF7N5O/c20-15-13(8-28-32-14(7-19(25,26)27)29-30-17(15)32)31-3-1-9(2-4-31)11-5-10(21)6-12(22)16(11)33-18(23)24/h5-6,8-9,18H,1-4,7H2
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Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160778
PNG
(US9682980, 8-Chloro-7-(4-phenylpiperidin-1-yl)-3-(...)
Show SMILES FC(F)(F)Cc1nnc2c(Cl)c(cnn12)N1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C18H17ClF3N5/c19-16-14(11-23-27-15(10-18(20,21)22)24-25-17(16)27)26-8-6-13(7-9-26)12-4-2-1-3-5-12/h1-5,11,13H,6-10H2
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Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160779
PNG
(US9682980, 3-Benzyl-8-chloro-7-(4-phenylpiperidin-...)
Show SMILES Clc1c(cnn2c(Cc3ccccc3)nnc12)N1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C23H22ClN5/c24-22-20(28-13-11-19(12-14-28)18-9-5-2-6-10-18)16-25-29-21(26-27-23(22)29)15-17-7-3-1-4-8-17/h1-10,16,19H,11-15H2
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Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160780
PNG
(US9682980, 8-Chloro-3-isobutyl-7-(4-phenylpiperidi...)
Show SMILES CC(C)Cc1nnc2c(Cl)c(cnn12)N1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C20H24ClN5/c1-14(2)12-18-23-24-20-19(21)17(13-22-26(18)20)25-10-8-16(9-11-25)15-6-4-3-5-7-15/h3-7,13-14,16H,8-12H2,1-2H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160782
PNG
(US9682980, 8-Chloro-3-(2-cyclopropylethyl)-7-(4-ph...)
Show SMILES Clc1c(cnn2c(CCC3CC3)nnc12)N1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C21H24ClN5/c22-20-18(26-12-10-17(11-13-26)16-4-2-1-3-5-16)14-23-27-19(24-25-21(20)27)9-8-15-6-7-15/h1-5,14-15,17H,6-13H2
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Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160785
PNG
(US9682980, 8-Chloro-7-(4-(2,3-dichlorophenyl)piper...)
Show SMILES FC(F)(F)Cc1nnc2c(Cl)c(cnn12)N1CCC(CC1)c1cccc(Cl)c1Cl
Show InChI InChI=1S/C18H15Cl3F3N5/c19-12-3-1-2-11(15(12)20)10-4-6-28(7-5-10)13-9-25-29-14(8-18(22,23)24)26-27-17(29)16(13)21/h1-3,9-10H,4-8H2
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Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160787
PNG
(US9682980, 8-Chloro-3-(cyclopropylmethyl)-N-(4-phe...)
Show SMILES Clc1c(NC2CCC(CC2)c2ccccc2)cnn2c(CC3CC3)nnc12
Show InChI InChI=1S/C21H24ClN5/c22-20-18(13-23-27-19(12-14-6-7-14)25-26-21(20)27)24-17-10-8-16(9-11-17)15-4-2-1-3-5-15/h1-5,13-14,16-17,24H,6-12H2
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Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160789
PNG
(US9682980, 1′-(8-Chloro-3-(cyclopropylmethyl...)
Show SMILES Clc1c(cnn2c(CC3CC3)nnc12)N1CCC2(CC1)C1C=CC=CC1OC2=O
Show InChI InChI=1S/C21H22ClN5O2/c22-18-15(12-23-27-17(11-13-5-6-13)24-25-19(18)27)26-9-7-21(8-10-26)14-3-1-2-4-16(14)29-20(21)28/h1-4,12-14,16H,5-11H2
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Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160791
PNG
(US9682980, 1′-(8-Chloro-3-(2,2,2-trifluoroet...)
Show SMILES FC(F)(F)Cc1nnc2c(Cl)c(cnn12)N1CCC2(CC1)C1C=CC=CC1OC2=O
Show InChI InChI=1S/C19H17ClF3N5O2/c20-15-12(10-24-28-14(9-19(21,22)23)25-26-16(15)28)27-7-5-18(6-8-27)11-3-1-2-4-13(11)30-17(18)29/h1-4,10-11,13H,5-9H2
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Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160793
PNG
(US9682980, 8-Chloro-N-(4-phenylcyclohexyl)-3-(2,2,...)
Show SMILES FC(F)(F)Cc1nnc2c(Cl)c(NC3CCC(CC3)c3ccccc3)cnn12
Show InChI InChI=1S/C19H19ClF3N5/c20-17-15(11-24-28-16(10-19(21,22)23)26-27-18(17)28)25-14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-5,11,13-14,25H,6-10H2
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Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160795
PNG
(US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-(2-...)
Show SMILES FC(F)(F)c1ccccc1C1CCN(CC1)c1cnn2c(CC3CC3)nnc2c1Cl
Show InChI InChI=1S/C21H21ClF3N5/c22-19-17(12-26-30-18(11-13-5-6-13)27-28-20(19)30)29-9-7-14(8-10-29)15-3-1-2-4-16(15)21(23,24)25/h1-4,12-14H,5-11H2
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Bristol-Myers Squibb Company

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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160797
PNG
(US9682980, 8-Chloro-3-(2,2,2-trifluoroethyl)-7-(4-...)
Show SMILES FC(F)(F)Cc1nnc2c(Cl)c(cnn12)N1CCC(CC1)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C19H16ClF6N5/c20-16-14(10-27-31-15(9-18(21,22)23)28-29-17(16)31)30-7-5-11(6-8-30)12-3-1-2-4-13(12)19(24,25)26/h1-4,10-11H,5-9H2
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Bristol-Myers Squibb Company

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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160800
PNG
(US9682980, 8-Chloro-7-(4-(2-fluorophenyl)piperidin...)
Show SMILES Fc1ccccc1C1CCN(CC1)c1ncn2c(CC(F)(F)F)nnc2c1Cl
Show InChI InChI=1S/C18H16ClF4N5/c19-15-16(24-10-28-14(9-18(21,22)23)25-26-17(15)28)27-7-5-11(6-8-27)12-3-1-2-4-13(12)20/h1-4,10-11H,5-9H2
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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160805
PNG
(US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-(2-...)
Show SMILES Fc1ccccc1C1CCN(CC1)c1ncn2c(CC3CC3)nnc2c1Cl
Show InChI InChI=1S/C20H21ClFN5/c21-18-19(23-12-27-17(11-13-5-6-13)24-25-20(18)27)26-9-7-14(8-10-26)15-3-1-2-4-16(15)22/h1-4,12-14H,5-11H2
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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160806
PNG
(US9682980, 8-Chloro-7-(4-(4-fluorophenyl)piperidin...)
Show SMILES Fc1ccc(cc1)C1CCN(CC1)c1ncn2c(CC(F)(F)F)nnc2c1Cl
Show InChI InChI=1S/C18H16ClF4N5/c19-15-16(24-10-28-14(9-18(21,22)23)25-26-17(15)28)27-7-5-12(6-8-27)11-1-3-13(20)4-2-11/h1-4,10,12H,5-9H2
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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160807
PNG
(US9682980, 3-(Cyclopropylmethyl)-7-(4-(2-fluoro-6-...)
Show SMILES COc1cccc(F)c1C1CCN(CC1)c1cnn2c(CC3CC3)nnc2c1C(F)(F)F
Show InChI InChI=1S/C22H23F4N5O/c1-32-17-4-2-3-15(23)19(17)14-7-9-30(10-8-14)16-12-27-31-18(11-13-5-6-13)28-29-21(31)20(16)22(24,25)26/h2-4,12-14H,5-11H2,1H3
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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160807
PNG
(US9682980, 3-(Cyclopropylmethyl)-7-(4-(2-fluoro-6-...)
Show SMILES COc1cccc(F)c1C1CCN(CC1)c1cnn2c(CC3CC3)nnc2c1C(F)(F)F
Show InChI InChI=1S/C22H23F4N5O/c1-32-17-4-2-3-15(23)19(17)14-7-9-30(10-8-14)16-12-27-31-18(11-13-5-6-13)28-29-21(31)20(16)22(24,25)26/h2-4,12-14H,5-11H2,1H3
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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160810
PNG
(US9682980, 2-(1-(8-Chloro-3-(cyclopropylmethyl)-[1...)
Show SMILES Clc1c(cnn2c(CC3CC3)nnc12)N1CCC(CC1)c1ccccc1C#N
Show InChI InChI=1S/C21H21ClN6/c22-20-18(13-24-28-19(11-14-5-6-14)25-26-21(20)28)27-9-7-15(8-10-27)17-4-2-1-3-16(17)12-23/h1-4,13-15H,5-11H2
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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160811
PNG
(US9682980, 2-(1-(8-chloro-3-(2,2,2-trifluoroethyl)...)
Show SMILES FC(F)(F)Cc1nnc2c(Cl)c(cnn12)N1CCC(CC1)c1ccccc1C#N
Show InChI InChI=1S/C19H16ClF3N6/c20-17-15(11-25-29-16(9-19(21,22)23)26-27-18(17)29)28-7-5-12(6-8-28)14-4-2-1-3-13(14)10-24/h1-4,11-12H,5-9H2
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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160812
PNG
(US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-(2,...)
Show SMILES Fc1ccc(C2CCN(CC2)c2cnn3c(CC4CC4)nnc3c2Cl)c(F)c1
Show InChI InChI=1S/C20H20ClF2N5/c21-19-17(11-24-28-18(9-12-1-2-12)25-26-20(19)28)27-7-5-13(6-8-27)15-4-3-14(22)10-16(15)23/h3-4,10-13H,1-2,5-9H2
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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160814
PNG
(US9682980, 8-Chloro-7-(4-(2,4-difluorophenyl)piper...)
Show SMILES Fc1ccc(C2CCN(CC2)c2cnn3c(CC(F)(F)F)nnc3c2Cl)c(F)c1
Show InChI InChI=1S/C18H15ClF5N5/c19-16-14(9-25-29-15(8-18(22,23)24)26-27-17(16)29)28-5-3-10(4-6-28)12-2-1-11(20)7-13(12)21/h1-2,7,9-10H,3-6,8H2
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Bristol-Myers Squibb Company

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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160815
PNG
(US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-(3-...)
Show SMILES FC(F)(F)c1cccc(n1)C1CCN(CC1)c1cnn2c(CC3CC3)nnc2c1Cl
Show InChI InChI=1S/C20H20ClF3N6/c21-18-15(11-25-30-17(10-12-4-5-12)27-28-19(18)30)29-8-6-13(7-9-29)14-2-1-3-16(26-14)20(22,23)24/h1-3,11-13H,4-10H2
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Bristol-Myers Squibb Company

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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160817
PNG
(US9682980, 2-(1-(3-(Cyclopropylmethyl)-8-(trifluor...)
Show SMILES FC(F)(F)c1c(cnn2c(CC3CC3)nnc12)N1CCC(CC1)c1ccccc1C#N
Show InChI InChI=1S/C22H21F3N6/c23-22(24,25)20-18(13-27-31-19(11-14-5-6-14)28-29-21(20)31)30-9-7-15(8-10-30)17-4-2-1-3-16(17)12-26/h1-4,13-15H,5-11H2
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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160818
PNG
(US9682980, 2-(1-(3-(2,2,2-Trifluoroethyl)-8-(trifl...)
Show SMILES FC(F)(F)Cc1nnc2c(c(cnn12)N1CCC(CC1)c1ccccc1C#N)C(F)(F)F
Show InChI InChI=1S/C20H16F6N6/c21-19(22,23)9-16-29-30-18-17(20(24,25)26)15(11-28-32(16)18)31-7-5-12(6-8-31)14-4-2-1-3-13(14)10-27/h1-4,11-12H,5-9H2
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Bristol-Myers Squibb Company

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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160820
PNG
(US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-(py...)
Show SMILES Clc1c(cnn2c(CC3CC3)nnc12)N1CCC(CC1)c1ccccn1
Show InChI InChI=1S/C19H21ClN6/c20-18-16(12-22-26-17(11-13-4-5-13)23-24-19(18)26)25-9-6-14(7-10-25)15-3-1-2-8-21-15/h1-3,8,12-14H,4-7,9-11H2
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Bristol-Myers Squibb Company

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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160821
PNG
(US9682980, 3-(Cyclopropylmethyl)-7-(4-(3,6-difluor...)
Show SMILES COc1c(F)ccc(F)c1C1CCN(CC1)c1cnn2c(CC3CC3)nnc2c1C(F)(F)F
Show InChI InChI=1S/C22H22F5N5O/c1-33-20-15(24)5-4-14(23)18(20)13-6-8-31(9-7-13)16-11-28-32-17(10-12-2-3-12)29-30-21(32)19(16)22(25,26)27/h4-5,11-13H,2-3,6-10H2,1H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160822
PNG
(US9682980, 7-(4-(3,6-Difluoro-2-methoxyphenyl)pipe...)
Show SMILES COc1c(F)ccc(F)c1C1CCN(CC1)c1cnn2c(CC(F)(F)F)nnc2c1C(F)(F)F
Show InChI InChI=1S/C20H17F8N5O/c1-34-17-12(22)3-2-11(21)15(17)10-4-6-32(7-5-10)13-9-29-33-14(8-19(23,24)25)30-31-18(33)16(13)20(26,27)28/h2-3,9-10H,4-8H2,1H3
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Bristol-Myers Squibb Company

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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160823
PNG
(US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-(py...)
Show SMILES Clc1c(cnn2c(CC3CC3)nnc12)N1CCC(CC1)c1cccnc1
Show InChI InChI=1S/C19H21ClN6/c20-18-16(12-22-26-17(10-13-3-4-13)23-24-19(18)26)25-8-5-14(6-9-25)15-2-1-7-21-11-15/h1-2,7,11-14H,3-6,8-10H2
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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160825
PNG
(US9682980, 8-Chloro-7-(4-(3-methoxypyridin-2-yl)pi...)
Show SMILES FC(F)(F)Cc1nnc2c(Cl)c(cnn12)N1CCC(CC1)c1ccccn1
Show InChI InChI=1S/C17H16ClF3N6/c18-15-13(10-23-27-14(9-17(19,20)21)24-25-16(15)27)26-7-4-11(5-8-26)12-3-1-2-6-22-12/h1-3,6,10-11H,4-5,7-9H2
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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160826
PNG
(US9682980, 3-(Cyclopropylmethyl)-7-(4-(2-fluorophe...)
Show SMILES Fc1ccccc1C1CCN(CC1)c1cnn2c(CC3CC3)nnc2c1C(F)(F)F
Show InChI InChI=1S/C21H21F4N5/c22-16-4-2-1-3-15(16)14-7-9-29(10-8-14)17-12-26-30-18(11-13-5-6-13)27-28-20(30)19(17)21(23,24)25/h1-4,12-14H,5-11H2
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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160828
PNG
(US9682980, Trans-N-((2-(2-methoxyphenyl)cyclopropy...)
Show SMILES COc1ccccc1C1CC1CNc1cnn2c(CC(F)(F)F)nnc2c1C(F)(F)F
Show InChI InChI=1S/C19H17F6N5O/c1-31-14-5-3-2-4-11(14)12-6-10(12)8-26-13-9-27-30-15(7-18(20,21)22)28-29-17(30)16(13)19(23,24)25/h2-5,9-10,12,26H,6-8H2,1H3
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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160547
PNG
(US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-phe...)
Show SMILES Clc1c(ncn2c(CC3CC3)nnc12)N1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C20H22ClN5/c21-18-19(22-13-26-17(12-14-6-7-14)23-24-20(18)26)25-10-8-16(9-11-25)15-4-2-1-3-5-15/h1-5,13-14,16H,6-12H2
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n/an/an/an/a 8n/an/a7.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160555
PNG
(US9682980, 3-(Cyclopropylmethyl)-8-methyl-7-(4-phe...)
Show SMILES Cc1c(ncn2c(CC3CC3)nnc12)N1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C21H25N5/c1-15-20(22-14-26-19(13-16-7-8-16)23-24-21(15)26)25-11-9-18(10-12-25)17-5-3-2-4-6-17/h2-6,14,16,18H,7-13H2,1H3
PDB

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Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160556
PNG
(US9682980, 3-(Cyclopropylmethyl)-7-(4-(4-fluorophe...)
Show SMILES COc1c(ncn2c(CC3CC3)nnc12)N1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C21H25N5O/c1-27-19-20(22-14-26-18(13-15-7-8-15)23-24-21(19)26)25-11-9-17(10-12-25)16-5-3-2-4-6-16/h2-6,14-15,17H,7-13H2,1H3
PDB

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Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160557
PNG
(US9682980, 3-(Cyclopropylmethyl)-7-(4-phenylpiperi...)
Show SMILES FC(F)(F)c1c(ncn2c(CC3CC3)nnc12)N1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C21H22F3N5/c22-21(23,24)18-19(25-13-29-17(12-14-6-7-14)26-27-20(18)29)28-10-8-16(9-11-28)15-4-2-1-3-5-15/h1-5,13-14,16H,6-12H2
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n/an/an/an/a 69n/an/a7.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160562
PNG
(US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-phe...)
Show SMILES Clc1c(cnn2c(CC3CC3)nnc12)N1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C20H22ClN5/c21-19-17(13-22-26-18(12-14-6-7-14)23-24-20(19)26)25-10-8-16(9-11-25)15-4-2-1-3-5-15/h1-5,13-14,16H,6-12H2
PDB

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n/an/an/an/a 19n/an/a7.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160566
PNG
(US9682980, 3-(Cyclopropylmethyl)-8-methyl-7-(4-phe...)
Show SMILES Cc1c(cnn2c(CC3CC3)nnc12)N1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C21H25N5/c1-15-19(14-22-26-20(13-16-7-8-16)23-24-21(15)26)25-11-9-18(10-12-25)17-5-3-2-4-6-17/h2-6,14,16,18H,7-13H2,1H3
PDB

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n/an/an/an/a 182n/an/a7.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160573
PNG
(US9682980, 3-(Cyclopropylmethyl)-7-(4-phenylpiperi...)
Show SMILES FC(F)(F)c1c(cnn2c(CC3CC3)nnc12)N1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C21H22F3N5/c22-21(23,24)19-17(13-25-29-18(12-14-6-7-14)26-27-20(19)29)28-10-8-16(9-11-28)15-4-2-1-3-5-15/h1-5,13-14,16H,6-12H2
PDB

UniProtKB/SwissProt

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n/an/an/an/a 3n/an/a7.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160574
PNG
(US9682980, 7-(4-Benzylpiperidin-1-yl)-8-chloro-3-(...)
Show SMILES Clc1c(ncn2c(CC3CC3)nnc12)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H24ClN5/c22-19-20(23-14-27-18(13-16-6-7-16)24-25-21(19)27)26-10-8-17(9-11-26)12-15-4-2-1-3-5-15/h1-5,14,16-17H,6-13H2
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
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UniChem
US Patent
n/an/an/an/a 61n/an/a7.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
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