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Found 375 hits Enz. Inhib. hit(s) with Target = 'Methionine Aminopeptidase (MAP)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM17853
PNG
(3,5-Pyrazolediamine Inhibitor, 3 | 3-imino-4-[(E)-...)
Show SMILES FC(F)(F)c1cccc(NN=c2c(=N)nnc2=N)c1
Show InChI InChI=1S/C10H7F3N6/c11-10(12,13)5-2-1-3-6(4-5)16-17-7-8(14)18-19-9(7)15/h1-4,14-16H
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n/an/a 250n/an/an/an/a7.530



The Procter & Gamble Pharmaceuticals



Assay Description
The inhibitory activity of a compound toward EcMAP was measured by incubating the compound at various concentrations in the presence of the enzyme an...


Proteins 66: 538-46 (2007)


Article DOI: 10.1002/prot.21207
BindingDB Entry DOI: 10.7270/Q2MK6B5Q
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine Aminopeptidase (MAP)


(Staphylococcus aureus)
BDBM17872
PNG
(1,2,4-triazole derivative. | 3-(benzylsulfanyl)-4-...)
Show SMILES Cn1cnnc1SCc1ccccc1
Show InChI InChI=1S/C10H11N3S/c1-13-8-11-12-10(13)14-7-9-5-3-2-4-6-9/h2-6,8H,7H2,1H3
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n/an/a>1.00E+5n/an/an/an/a7.522



Morphochem AG



Assay Description
The MetAP reaction with Co2+ as a cofactor is coupled to a prolyl aminopeptidase (ProAP) using Met-Pro-p-nitroanilide as substrate. MetAP-catalyzed c...


J Mol Biol 332: 13-21 (2003)


BindingDB Entry DOI: 10.7270/Q2C53J49
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM17855
PNG
(3,5-Pyrazolediamine Inhibitor, 5 | 4-[(E)-2-(3-flu...)
Show SMILES Fc1cccc(NN=c2c(=N)nnc2=N)c1
Show InChI InChI=1S/C9H7FN6/c10-5-2-1-3-6(4-5)13-14-7-8(11)15-16-9(7)12/h1-4,11-13H
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n/an/a 550n/an/an/an/a7.530



The Procter & Gamble Pharmaceuticals



Assay Description
The inhibitory activity of a compound toward EcMAP was measured by incubating the compound at various concentrations in the presence of the enzyme an...


Proteins 66: 538-46 (2007)


Article DOI: 10.1002/prot.21207
BindingDB Entry DOI: 10.7270/Q2MK6B5Q
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM17856
PNG
(3,5-Pyrazolediamine Inhibitor, 6 | 4-[(E)-2-(3-chl...)
Show SMILES Cc1c(Cl)cccc1NN=c1c(=N)nnc1=N
Show InChI InChI=1S/C10H9ClN6/c1-5-6(11)3-2-4-7(5)14-15-8-9(12)16-17-10(8)13/h2-4,12-14H,1H3
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n/an/a 550n/an/an/an/a7.530



The Procter & Gamble Pharmaceuticals



Assay Description
The inhibitory activity of a compound toward EcMAP was measured by incubating the compound at various concentrations in the presence of the enzyme an...


Proteins 66: 538-46 (2007)


Article DOI: 10.1002/prot.21207
BindingDB Entry DOI: 10.7270/Q2MK6B5Q
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM17857
PNG
(3,5-Pyrazolediamine Inhibitor, 7 | 4-[(E)-2-(4-flu...)
Show SMILES Fc1ccc(NN=c2c(=N)nnc2=N)cc1
Show InChI InChI=1S/C9H7FN6/c10-5-1-3-6(4-2-5)13-14-7-8(11)15-16-9(7)12/h1-4,11-13H
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n/an/a 580n/an/an/an/a7.530



The Procter & Gamble Pharmaceuticals



Assay Description
The inhibitory activity of a compound toward EcMAP was measured by incubating the compound at various concentrations in the presence of the enzyme an...


Proteins 66: 538-46 (2007)


Article DOI: 10.1002/prot.21207
BindingDB Entry DOI: 10.7270/Q2MK6B5Q
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM17858
PNG
(3,5-Pyrazolediamine Inhibitor, 8 | 4-[(E)-2-(4-chl...)
Show SMILES Clc1ccc(NN=c2c(=N)nnc2=N)cc1
Show InChI InChI=1S/C9H7ClN6/c10-5-1-3-6(4-2-5)13-14-7-8(11)15-16-9(7)12/h1-4,11-13H
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n/an/a 1.25E+3n/an/an/an/a7.530



The Procter & Gamble Pharmaceuticals



Assay Description
The inhibitory activity of a compound toward EcMAP was measured by incubating the compound at various concentrations in the presence of the enzyme an...


Proteins 66: 538-46 (2007)


Article DOI: 10.1002/prot.21207
BindingDB Entry DOI: 10.7270/Q2MK6B5Q
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM17859
PNG
(3,5-Pyrazolediamine Inhibitor, 9 | 3-imino-4-[(E)-...)
Show SMILES COc1ccc(NN=c2c(=N)nnc2=N)cc1
Show InChI InChI=1S/C10H10N6O/c1-17-7-4-2-6(3-5-7)13-14-8-9(11)15-16-10(8)12/h2-5,11-13H,1H3
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n/an/a 1.50E+3n/an/an/an/a7.530



The Procter & Gamble Pharmaceuticals



Assay Description
The inhibitory activity of a compound toward EcMAP was measured by incubating the compound at various concentrations in the presence of the enzyme an...


Proteins 66: 538-46 (2007)


Article DOI: 10.1002/prot.21207
BindingDB Entry DOI: 10.7270/Q2MK6B5Q
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM17860
PNG
(3,5-Pyrazolediamine Inhibitor, 2 | 3-[(E)-2-(5-ami...)
Show SMILES OC(=O)c1cccc(NN=c2c(=N)nnc2=N)c1
Show InChI InChI=1S/C10H8N6O2/c11-8-7(9(12)16-15-8)14-13-6-3-1-2-5(4-6)10(17)18/h1-4,11-13H,(H,17,18)
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n/an/a 1.75E+3n/an/an/an/a7.530



The Procter & Gamble Pharmaceuticals



Assay Description
The inhibitory activity of a compound toward EcMAP was measured by incubating the compound at various concentrations in the presence of the enzyme an...


Proteins 66: 538-46 (2007)


Article DOI: 10.1002/prot.21207
BindingDB Entry DOI: 10.7270/Q2MK6B5Q
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM17861
PNG
(3,5-Pyrazolediamine Inhibitor, 10 | 3-[(E)-2-(5-am...)
Show SMILES OC(=O)c1cccc(NN=c2c(=N)nnc2=N)c1O
Show InChI InChI=1S/C10H8N6O3/c11-8-6(9(12)16-15-8)14-13-5-3-1-2-4(7(5)17)10(18)19/h1-3,11-13,17H,(H,18,19)
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n/an/a 2.00E+3n/an/an/an/a7.530



The Procter & Gamble Pharmaceuticals



Assay Description
The inhibitory activity of a compound toward EcMAP was measured by incubating the compound at various concentrations in the presence of the enzyme an...


Proteins 66: 538-46 (2007)


Article DOI: 10.1002/prot.21207
BindingDB Entry DOI: 10.7270/Q2MK6B5Q
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM17862
PNG
(({4-[(E)-2-(5-amino-3-imino-3H-pyrazol-4-yl)diazen...)
Show SMILES NC(N)=NNS(=O)(=O)c1ccc(NN=c2c(=N)nnc2=N)cc1
Show InChI InChI=1S/C10H12N10O2S/c11-8-7(9(12)18-17-8)16-15-5-1-3-6(4-2-5)23(21,22)20-19-10(13)14/h1-4,11-12,15,20H,(H4,13,14,19)
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n/an/a 2.00E+4n/an/an/an/a7.530



The Procter & Gamble Pharmaceuticals



Assay Description
The inhibitory activity of a compound toward EcMAP was measured by incubating the compound at various concentrations in the presence of the enzyme an...


Proteins 66: 538-46 (2007)


Article DOI: 10.1002/prot.21207
BindingDB Entry DOI: 10.7270/Q2MK6B5Q
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM17863
PNG
(Amino-Alcohol Inhibitor, 12 | methyl 2-[(2S)-2-[(2...)
Show SMILES COC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](O)[C@H](N)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C16H20F3N3O5/c1-8(14(25)21-7-11(23)27-2)22-15(26)13(24)12(20)9-3-5-10(6-4-9)16(17,18)19/h3-6,8,12-13,24H,7,20H2,1-2H3,(H,21,25)(H,22,26)/t8-,12+,13-/m0/s1
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n/an/a 1.70E+3n/an/an/an/a7.530



The Procter & Gamble Pharmaceuticals



Assay Description
The inhibitory activity of a compound toward EcMAP was measured by incubating the compound at various concentrations in the presence of the enzyme an...


Proteins 66: 538-46 (2007)


Article DOI: 10.1002/prot.21207
BindingDB Entry DOI: 10.7270/Q2MK6B5Q
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM17864
PNG
(Amino-Alcohol Inhibitor, 13 | methyl (2S)-2-[(2S)-...)
Show SMILES COC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](O)[C@H](N)c1ccc(cc1)C(C)C
Show InChI InChI=1S/C22H35N3O5/c1-12(2)11-17(22(29)30-6)25-20(27)14(5)24-21(28)19(26)18(23)16-9-7-15(8-10-16)13(3)4/h7-10,12-14,17-19,26H,11,23H2,1-6H3,(H,24,28)(H,25,27)/t14-,17-,18+,19-/m0/s1
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n/an/a 3.50E+3n/an/an/an/a7.530



The Procter & Gamble Pharmaceuticals



Assay Description
The inhibitory activity of a compound toward EcMAP was measured by incubating the compound at various concentrations in the presence of the enzyme an...


Proteins 66: 538-46 (2007)


Article DOI: 10.1002/prot.21207
BindingDB Entry DOI: 10.7270/Q2MK6B5Q
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM17865
PNG
(Amino-Alcohol Inhibitor, 14 | methyl (2S)-2-[(2S)-...)
Show SMILES CCCC[C@@H](N)[C@H](O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)OC
Show InChI InChI=1S/C17H33N3O6/c1-5-6-7-11(18)14(22)16(24)20-13(9-21)15(23)19-12(8-10(2)3)17(25)26-4/h10-14,21-22H,5-9,18H2,1-4H3,(H,19,23)(H,20,24)/t11-,12+,13+,14+/m1/s1
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n/an/a 1.20E+4n/an/an/an/a7.530



The Procter & Gamble Pharmaceuticals



Assay Description
The inhibitory activity of a compound toward EcMAP was measured by incubating the compound at various concentrations in the presence of the enzyme an...


Proteins 66: 538-46 (2007)


Article DOI: 10.1002/prot.21207
BindingDB Entry DOI: 10.7270/Q2MK6B5Q
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM17866
PNG
(Amino-Alcohol Inhibitor, 15 | methyl (2S)-2-[(2S)-...)
Show SMILES COC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](O)[C@H](N)c1ccc(C)cc1
Show InChI InChI=1S/C20H31N3O5/c1-11(2)10-15(20(27)28-5)23-18(25)13(4)22-19(26)17(24)16(21)14-8-6-12(3)7-9-14/h6-9,11,13,15-17,24H,10,21H2,1-5H3,(H,22,26)(H,23,25)/t13-,15-,16+,17-/m0/s1
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n/an/a 2.50E+4n/an/an/an/a7.530



The Procter & Gamble Pharmaceuticals



Assay Description
The inhibitory activity of a compound toward EcMAP was measured by incubating the compound at various concentrations in the presence of the enzyme an...


Proteins 66: 538-46 (2007)


Article DOI: 10.1002/prot.21207
BindingDB Entry DOI: 10.7270/Q2MK6B5Q
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Staphylococcus aureus)
BDBM17867
PNG
((2S)-2-amino-4-(methylsulfanyl)-1-(1,3-thiazol-2-y...)
Show SMILES CSCC[C@H](N)C(=O)c1nccs1
Show InChI InChI=1S/C8H12N2OS2/c1-12-4-2-6(9)7(11)8-10-3-5-13-8/h3,5-6H,2,4,9H2,1H3/t6-/m0/s1
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n/an/a 1.90E+4n/an/an/an/a7.522



Morphochem AG



Assay Description
The MetAP reaction with Co2+ as a cofactor is coupled to a prolyl aminopeptidase (ProAP) using Met-Pro-p-nitroanilide as substrate. MetAP-catalyzed c...


J Med Chem 47: 1325-8 (2004)


Article DOI: 10.1021/jm034188j
BindingDB Entry DOI: 10.7270/Q2GX48TV
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Methionine Aminopeptidase (MAP)


(Staphylococcus aureus)
BDBM17868
PNG
((2S)-2-amino-4-(methylsulfanyl)-1-(pyridin-2-yl)bu...)
Show SMILES CSCC[C@H](N)C(=O)c1ccccn1
Show InChI InChI=1S/C10H14N2OS/c1-14-7-5-8(11)10(13)9-4-2-3-6-12-9/h2-4,6,8H,5,7,11H2,1H3/t8-/m0/s1
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n/an/a 1.60E+4n/an/an/an/a7.522



Morphochem AG



Assay Description
The MetAP reaction with Co2+ as a cofactor is coupled to a prolyl aminopeptidase (ProAP) using Met-Pro-p-nitroanilide as substrate. MetAP-catalyzed c...


J Med Chem 47: 1325-8 (2004)


Article DOI: 10.1021/jm034188j
BindingDB Entry DOI: 10.7270/Q2GX48TV
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Methionine Aminopeptidase (MAP)


(Staphylococcus aureus)
BDBM17869
PNG
((3S)-3-amino-1-(cyclopropylamino)heptane-2,2-diol ...)
Show SMILES CCCC[C@H](N)C(=O)CNC1CC1
Show InChI InChI=1S/C10H20N2O/c1-2-3-4-9(11)10(13)7-12-8-5-6-8/h8-9,12H,2-7,11H2,1H3/t9-/m0/s1
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n/an/a 7.00E+3n/an/an/an/a7.522



Morphochem AG



Assay Description
The MetAP reaction with Co2+ as a cofactor is coupled to a prolyl aminopeptidase (ProAP) using Met-Pro-p-nitroanilide as substrate. MetAP-catalyzed c...


J Med Chem 47: 1325-8 (2004)


Article DOI: 10.1021/jm034188j
BindingDB Entry DOI: 10.7270/Q2GX48TV
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Methionine Aminopeptidase (MAP)


(Staphylococcus aureus)
BDBM17870
PNG
(1,2,4-triazole derivative. | 5-(benzylsulfanyl)-4H...)
Show SMILES Nc1nnc(SCc2ccccc2)[nH]1
Show InChI InChI=1S/C9H10N4S/c10-8-11-9(13-12-8)14-6-7-4-2-1-3-5-7/h1-5H,6H2,(H3,10,11,12,13)
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n/an/a 599n/an/an/an/a7.522



Morphochem AG



Assay Description
The MetAP reaction with Co2+ as a cofactor is coupled to a prolyl aminopeptidase (ProAP) using Met-Pro-p-nitroanilide as substrate. MetAP-catalyzed c...


J Mol Biol 332: 13-21 (2003)


BindingDB Entry DOI: 10.7270/Q2C53J49
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Staphylococcus aureus)
BDBM17871
PNG
((1S)-1-[5-(benzylsulfanyl)-4H-1,2,4-triazol-3-yl]-...)
Show SMILES CSCC[C@H](N)c1nnc(SCc2ccccc2)[nH]1
Show InChI InChI=1S/C13H18N4S2/c1-18-8-7-11(14)12-15-13(17-16-12)19-9-10-5-3-2-4-6-10/h2-6,11H,7-9,14H2,1H3,(H,15,16,17)/t11-/m0/s1
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n/an/a 43.7n/an/an/an/a7.522



Morphochem AG



Assay Description
The MetAP reaction with Co2+ as a cofactor is coupled to a prolyl aminopeptidase (ProAP) using Met-Pro-p-nitroanilide as substrate. MetAP-catalyzed c...


J Mol Biol 332: 13-21 (2003)


BindingDB Entry DOI: 10.7270/Q2C53J49
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM17854
PNG
(3,5-Pyrazolediamine Inhibitor, 4 | 3-imino-4-[(E)-...)
Show SMILES FC(F)(F)c1ccccc1NN=c1c(=N)nnc1=N
Show InChI InChI=1S/C10H7F3N6/c11-10(12,13)5-3-1-2-4-6(5)16-17-7-8(14)18-19-9(7)15/h1-4,14-16H
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n/an/a 250n/an/an/an/a7.530



The Procter & Gamble Pharmaceuticals



Assay Description
The inhibitory activity of a compound toward EcMAP was measured by incubating the compound at various concentrations in the presence of the enzyme an...


Proteins 66: 538-46 (2007)


Article DOI: 10.1002/prot.21207
BindingDB Entry DOI: 10.7270/Q2MK6B5Q
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50160044
PNG
(4-Benzyloxy-pyridine-2-carboxylic acid thiazol-2-y...)
Show SMILES O=C(Nc1nccs1)c1cc(OCc2ccccc2)ccn1
Show InChI InChI=1S/C16H13N3O2S/c20-15(19-16-18-8-9-22-16)14-10-13(6-7-17-14)21-11-12-4-2-1-3-5-12/h1-10H,11H2,(H,18,19,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against Escherichia coli methionine aminopeptidase 1


Bioorg Med Chem Lett 15: 635-8 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.034
BindingDB Entry DOI: 10.7270/Q2222T7R
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50160045
PNG
(CHEMBL179906 | [6-(Thiazol-2-ylcarbamoyl)-pyridin-...)
Show SMILES CC(C)(C)OC(=O)Nc1ccc(nc1)C(=O)Nc1nccs1
Show InChI InChI=1S/C14H16N4O3S/c1-14(2,3)21-13(20)17-9-4-5-10(16-8-9)11(19)18-12-15-6-7-22-12/h4-8H,1-3H3,(H,17,20)(H,15,18,19)
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n/an/a 1.28E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against Escherichia coli methionine aminopeptidase 1


Bioorg Med Chem Lett 15: 635-8 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.034
BindingDB Entry DOI: 10.7270/Q2222T7R
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50129672
PNG
(3-Propionylamino-pyridine-2-carboxylic acid thiazo...)
Show SMILES CCC(=O)Nc1cccnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C12H12N4O2S/c1-2-9(17)15-8-4-3-5-13-10(8)11(18)16-12-14-6-7-19-12/h3-7H,2H2,1H3,(H,15,17)(H,14,16,18)
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n/an/a 260n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against Escherichia coli methionine aminopeptidase 1


Bioorg Med Chem Lett 15: 635-8 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.034
BindingDB Entry DOI: 10.7270/Q2222T7R
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50160047
PNG
(6-(Thiazol-2-ylcarbamoyl)-pyridine-2-carboxylic ac...)
Show SMILES OC(=O)c1cccc(n1)C(=O)Nc1nccs1
Show InChI InChI=1S/C10H7N3O3S/c14-8(13-10-11-4-5-17-10)6-2-1-3-7(12-6)9(15)16/h1-5H,(H,15,16)(H,11,13,14)
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n/an/a 5.82E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against Escherichia coli methionine aminopeptidase 1


Bioorg Med Chem Lett 15: 635-8 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.034
BindingDB Entry DOI: 10.7270/Q2222T7R
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50160048
PNG
(Acetic acid 6-(thiazol-2-ylcarbamoyl)-pyridin-2-yl...)
Show SMILES CC(=O)OCc1cccc(n1)C(=O)Nc1nccs1
Show InChI InChI=1S/C12H11N3O3S/c1-8(16)18-7-9-3-2-4-10(14-9)11(17)15-12-13-5-6-19-12/h2-6H,7H2,1H3,(H,13,15,17)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against Escherichia coli methionine aminopeptidase 1


Bioorg Med Chem Lett 15: 635-8 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.034
BindingDB Entry DOI: 10.7270/Q2222T7R
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50160049
PNG
(3-Methoxy-pyridine-2-carboxylic acid thiazol-2-yla...)
Show SMILES COc1cccnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C10H9N3O2S/c1-15-7-3-2-4-11-8(7)9(14)13-10-12-5-6-16-10/h2-6H,1H3,(H,12,13,14)
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n/an/a 4.49E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against Escherichia coli methionine aminopeptidase 1


Bioorg Med Chem Lett 15: 635-8 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.034
BindingDB Entry DOI: 10.7270/Q2222T7R
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50160050
PNG
(4-Methoxy-pyridine-2-carboxylic acid thiazol-2-yla...)
Show SMILES COc1ccnc(c1)C(=O)Nc1nccs1
Show InChI InChI=1S/C10H9N3O2S/c1-15-7-2-3-11-8(6-7)9(14)13-10-12-4-5-16-10/h2-6H,1H3,(H,12,13,14)
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n/an/a 9.22E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against Escherichia coli methionine aminopeptidase 1


Bioorg Med Chem Lett 15: 635-8 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.034
BindingDB Entry DOI: 10.7270/Q2222T7R
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50160052
PNG
(5-Butyl-pyridine-2-carboxylic acid thiazol-2-ylami...)
Show SMILES CCCCc1ccc(nc1)C(=O)Nc1nccs1
Show InChI InChI=1S/C13H15N3OS/c1-2-3-4-10-5-6-11(15-9-10)12(17)16-13-14-7-8-18-13/h5-9H,2-4H2,1H3,(H,14,16,17)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against Escherichia coli methionine aminopeptidase 1


Bioorg Med Chem Lett 15: 635-8 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.034
BindingDB Entry DOI: 10.7270/Q2222T7R
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50160046
PNG
(4-Chloro-pyridine-2-carboxylic acid thiazol-2-ylam...)
Show SMILES Clc1ccnc(c1)C(=O)Nc1nccs1
Show InChI InChI=1S/C9H6ClN3OS/c10-6-1-2-11-7(5-6)8(14)13-9-12-3-4-15-9/h1-5H,(H,12,13,14)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against Escherichia coli methionine aminopeptidase 1


Bioorg Med Chem Lett 15: 635-8 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.034
BindingDB Entry DOI: 10.7270/Q2222T7R
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50129671
PNG
(Benzoic acid 2-(thiazol-2-ylcarbamoyl)-pyridin-3-y...)
Show SMILES O=C(Nc1nccs1)c1ncccc1OC(=O)c1ccccc1
Show InChI InChI=1S/C16H11N3O3S/c20-14(19-16-18-9-10-23-16)13-12(7-4-8-17-13)22-15(21)11-5-2-1-3-6-11/h1-10H,(H,18,19,20)
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n/an/a 1.22E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against Escherichia coli methionine aminopeptidase 1


Bioorg Med Chem Lett 15: 635-8 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.034
BindingDB Entry DOI: 10.7270/Q2222T7R
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50160054
PNG
(5-But-3-enoylamino-pyridine-2-carboxylic acid thia...)
Show SMILES C=CCC(=O)Nc1ccc(nc1)C(=O)Nc1nccs1
Show InChI InChI=1S/C13H12N4O2S/c1-2-3-11(18)16-9-4-5-10(15-8-9)12(19)17-13-14-6-7-20-13/h2,4-8H,1,3H2,(H,16,18)(H,14,17,19)
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n/an/a 1.01E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against Escherichia coli methionine aminopeptidase 1


Bioorg Med Chem Lett 15: 635-8 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.034
BindingDB Entry DOI: 10.7270/Q2222T7R
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50160055
PNG
(CHEMBL183821 | Pyridine-2,6-dicarboxylic acid bis-...)
Show SMILES O=C(Nc1nccs1)c1cccc(n1)C(=O)Nc1nccs1
Show InChI InChI=1S/C13H9N5O2S2/c19-10(17-12-14-4-6-21-12)8-2-1-3-9(16-8)11(20)18-13-15-5-7-22-13/h1-7H,(H,14,17,19)(H,15,18,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against Escherichia coli methionine aminopeptidase 1


Bioorg Med Chem Lett 15: 635-8 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.034
BindingDB Entry DOI: 10.7270/Q2222T7R
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50160057
PNG
(5-(3-Methyl-but-2-enyl)-pyridine-2-carboxylic acid...)
Show SMILES CC(C)=CCc1ccc(nc1)C(=O)Nc1nccs1
Show InChI InChI=1S/C14H15N3OS/c1-10(2)3-4-11-5-6-12(16-9-11)13(18)17-14-15-7-8-19-14/h3,5-9H,4H2,1-2H3,(H,15,17,18)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against Escherichia coli methionine aminopeptidase 1


Bioorg Med Chem Lett 15: 635-8 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.034
BindingDB Entry DOI: 10.7270/Q2222T7R
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50160056
PNG
(4-Amino-pyridine-2-carboxylic acid thiazol-2-ylami...)
Show SMILES Nc1ccnc(c1)C(=O)Nc1nccs1
Show InChI InChI=1S/C9H8N4OS/c10-6-1-2-11-7(5-6)8(14)13-9-12-3-4-15-9/h1-5H,(H2,10,11)(H,12,13,14)
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n/an/a 6.71E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against Escherichia coli methionine aminopeptidase 1


Bioorg Med Chem Lett 15: 635-8 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.034
BindingDB Entry DOI: 10.7270/Q2222T7R
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50129656
PNG
(3-Hexanoylamino-pyridine-2-carboxylic acid thiazol...)
Show SMILES CCCCCC(=O)Nc1cccnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C15H18N4O2S/c1-2-3-4-7-12(20)18-11-6-5-8-16-13(11)14(21)19-15-17-9-10-22-15/h5-6,8-10H,2-4,7H2,1H3,(H,18,20)(H,17,19,21)
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n/an/a 380n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against Escherichia coli methionine aminopeptidase 1


Bioorg Med Chem Lett 15: 635-8 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.034
BindingDB Entry DOI: 10.7270/Q2222T7R
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50160060
PNG
(6-Hydroxymethyl-pyridine-2-carboxylic acid thiazol...)
Show SMILES OCc1cccc(n1)C(=O)Nc1nccs1
Show InChI InChI=1S/C10H9N3O2S/c14-6-7-2-1-3-8(12-7)9(15)13-10-11-4-5-16-10/h1-5,14H,6H2,(H,11,13,15)
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n/an/a 5.82E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against Escherichia coli methionine aminopeptidase 1


Bioorg Med Chem Lett 15: 635-8 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.034
BindingDB Entry DOI: 10.7270/Q2222T7R
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50160059
PNG
(4-Nitrooxy-pyridine-2-carboxylic acid thiazol-2-yl...)
Show SMILES [O-][N+](=O)c1ccnc(c1)C(=O)Nc1nccs1
Show InChI InChI=1S/C9H6N4O3S/c14-8(12-9-11-3-4-17-9)7-5-6(13(15)16)1-2-10-7/h1-5H,(H,11,12,14)
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n/an/a 4.51E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against Escherichia coli methionine aminopeptidase 1


Bioorg Med Chem Lett 15: 635-8 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.034
BindingDB Entry DOI: 10.7270/Q2222T7R
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50160051
PNG
(4-Acetylaminooxy-pyridine-2-carboxylic acid thiazo...)
Show SMILES CC(=O)NOc1ccnc(c1)C(=O)Nc1nccs1
Show InChI InChI=1S/C11H10N4O3S/c1-7(16)15-18-8-2-3-12-9(6-8)10(17)14-11-13-4-5-19-11/h2-6H,1H3,(H,15,16)(H,13,14,17)
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n/an/a 1.98E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against Escherichia coli methionine aminopeptidase 1


Bioorg Med Chem Lett 15: 635-8 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.034
BindingDB Entry DOI: 10.7270/Q2222T7R
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50129661
PNG
(CHEMBL89671 | N-(thiazol-2-yl)picolinamide | Pyrid...)
Show SMILES O=C(Nc1nccs1)c1ccccn1
Show InChI InChI=1S/C9H7N3OS/c13-8(7-3-1-2-4-10-7)12-9-11-5-6-14-9/h1-6H,(H,11,12,13)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against Escherichia coli methionine aminopeptidase 1


Bioorg Med Chem Lett 15: 635-8 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.034
BindingDB Entry DOI: 10.7270/Q2222T7R
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50160053
PNG
(5-Amino-pyridine-2-carboxylic acid thiazol-2-ylami...)
Show SMILES Nc1ccc(nc1)C(=O)Nc1nccs1
Show InChI InChI=1S/C9H8N4OS/c10-6-1-2-7(12-5-6)8(14)13-9-11-3-4-15-9/h1-5H,10H2,(H,11,13,14)
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n/an/a 2.09E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against Escherichia coli methionine aminopeptidase 1


Bioorg Med Chem Lett 15: 635-8 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.034
BindingDB Entry DOI: 10.7270/Q2222T7R
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50160058
PNG
(4-Benzylamino-pyridine-2-carboxylic acid thiazol-2...)
Show SMILES O=C(Nc1nccs1)c1cc(NCc2ccccc2)ccn1
Show InChI InChI=1S/C16H14N4OS/c21-15(20-16-18-8-9-22-16)14-10-13(6-7-17-14)19-11-12-4-2-1-3-5-12/h1-10H,11H2,(H,17,19)(H,18,20,21)
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n/an/a 2.32E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against Escherichia coli methionine aminopeptidase 1


Bioorg Med Chem Lett 15: 635-8 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.034
BindingDB Entry DOI: 10.7270/Q2222T7R
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50160043
PNG
(3-Benzyloxy-pyridine-2-carboxylic acid thiazol-2-y...)
Show SMILES O=C(Nc1nccs1)c1ncccc1OCc1ccccc1
Show InChI InChI=1S/C16H13N3O2S/c20-15(19-16-18-9-10-22-16)14-13(7-4-8-17-14)21-11-12-5-2-1-3-6-12/h1-10H,11H2,(H,18,19,20)
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n/an/a 1.41E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory concentration against Escherichia coli methionine aminopeptidase 1


Bioorg Med Chem Lett 15: 635-8 (2005)


Article DOI: 10.1016/j.bmcl.2004.11.034
BindingDB Entry DOI: 10.7270/Q2222T7R
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50175421
PNG
(5-(2-aminophenyl)furan-2-carboxylic acid | CHEMBL3...)
Show SMILES Nc1ccccc1-c1ccc(o1)C(O)=O
Show InChI InChI=1S/C11H9NO3/c12-8-4-2-1-3-7(8)9-5-6-10(15-9)11(13)14/h1-6H,12H2,(H,13,14)
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n/an/a 5.66E+4n/an/an/an/an/an/a



Graduate School of Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against Co(II) form of Escherichia coli MetAP


Bioorg Med Chem Lett 15: 5386-91 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.019
BindingDB Entry DOI: 10.7270/Q2HH6JNV
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50175423
PNG
(5-(2-(hydroxymethyl)phenyl)furan-2-carboxylic acid...)
Show SMILES OCc1ccccc1-c1ccc(o1)C(O)=O
Show InChI InChI=1S/C12H10O4/c13-7-8-3-1-2-4-9(8)10-5-6-11(16-10)12(14)15/h1-6,13H,7H2,(H,14,15)
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n/an/a>2.00E+5n/an/an/an/an/an/a



Graduate School of Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against Fe(II) form of Escherichia coli MetAP


Bioorg Med Chem Lett 15: 5386-91 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.019
BindingDB Entry DOI: 10.7270/Q2HH6JNV
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50175422
PNG
(5-phenylfuran-2-carboxylic acid | CHEMBL200666)
Show SMILES OC(=O)c1ccc(o1)-c1ccccc1
Show InChI InChI=1S/C11H8O3/c12-11(13)10-7-6-9(14-10)8-4-2-1-3-5-8/h1-7H,(H,12,13)
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n/an/a 1.95E+5n/an/an/an/an/an/a



Graduate School of Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against Ni(II) form of Escherichia coli MetAP


Bioorg Med Chem Lett 15: 5386-91 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.019
BindingDB Entry DOI: 10.7270/Q2HH6JNV
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50175424
PNG
(5-(2-(2-methoxyethoxy)phenyl)furan-2-carboxylic ac...)
Show SMILES COCCOc1ccccc1-c1ccc(o1)C(O)=O
Show InChI InChI=1S/C14H14O5/c1-17-8-9-18-11-5-3-2-4-10(11)12-6-7-13(19-12)14(15)16/h2-7H,8-9H2,1H3,(H,15,16)
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n/an/a 9.45E+3n/an/an/an/an/an/a



Graduate School of Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against Mn(II) form of Escherichia coli MetAP


Bioorg Med Chem Lett 15: 5386-91 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.019
BindingDB Entry DOI: 10.7270/Q2HH6JNV
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50175425
PNG
(5-(2-chlorophenyl)furan-2-carbohydrazide | CHEMBL2...)
Show SMILES NNC(=O)c1ccc(o1)-c1ccccc1Cl
Show InChI InChI=1S/C11H9ClN2O2/c12-8-4-2-1-3-7(8)9-5-6-10(16-9)11(15)14-13/h1-6H,13H2,(H,14,15)
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n/an/a 6.56E+3n/an/an/an/an/an/a



Graduate School of Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against Mn(II) form of Escherichia coli MetAP


Bioorg Med Chem Lett 15: 5386-91 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.019
BindingDB Entry DOI: 10.7270/Q2HH6JNV
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50175423
PNG
(5-(2-(hydroxymethyl)phenyl)furan-2-carboxylic acid...)
Show SMILES OCc1ccccc1-c1ccc(o1)C(O)=O
Show InChI InChI=1S/C12H10O4/c13-7-8-3-1-2-4-9(8)10-5-6-11(16-10)12(14)15/h1-6,13H,7H2,(H,14,15)
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n/an/a 1.89E+5n/an/an/an/an/an/a



Graduate School of Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against Co(II) form of Escherichia coli MetAP


Bioorg Med Chem Lett 15: 5386-91 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.019
BindingDB Entry DOI: 10.7270/Q2HH6JNV
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50175426
PNG
(2-(5-(2-chlorophenyl)furan-2-yl)acetonitrile | CHE...)
Show SMILES Clc1ccccc1-c1ccc(CC#N)o1
Show InChI InChI=1S/C12H8ClNO/c13-11-4-2-1-3-10(11)12-6-5-9(15-12)7-8-14/h1-6H,7H2
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n/an/a 5.73E+4n/an/an/an/an/an/a



Graduate School of Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against Co(II) form of Escherichia coli MetAP


Bioorg Med Chem Lett 15: 5386-91 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.019
BindingDB Entry DOI: 10.7270/Q2HH6JNV
More data for this
Ligand-Target Pair
Methionine Aminopeptidase (MAP)


(Escherichia coli (strain K12))
BDBM50175428
PNG
(2-(5-(2-chlorobenzyl)furan-2-yl)acetic acid | CHEM...)
Show SMILES OC(=O)Cc1ccc(Cc2ccccc2Cl)o1
Show InChI InChI=1S/C13H11ClO3/c14-12-4-2-1-3-9(12)7-10-5-6-11(17-10)8-13(15)16/h1-6H,7-8H2,(H,15,16)
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n/an/a 7.73E+4n/an/an/an/an/an/a



Graduate School of Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against Co(II) form of Escherichia coli MetAP


Bioorg Med Chem Lett 15: 5386-91 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.019
BindingDB Entry DOI: 10.7270/Q2HH6JNV
More data for this
Ligand-Target Pair
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