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Found 1305 Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase kinase kinase kinase 4'
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM50541592(CHEMBL3187788)
Affinity DataKi:  0.400nMAssay Description:Inhibition of NIK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM225885(MAP02)
Affinity DataKi:  2.20nM IC50:  5.84nMAssay Description:Z'Lyte AssayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM225901(MAP19 | US9855269, Compound 342)
Affinity DataKi:  3.66nM IC50:  3.11nMAssay Description:Z'Lyte AssayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM225893(MAP12)
Affinity DataKi:  4.61nM IC50:  3.88nMAssay Description:Z'Lyte AssayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM225889(MAP07)
Affinity DataKi:  7.79nM IC50:  5.94nMAssay Description:Z'Lyte AssayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM225896(MAP15 | US9592235, Example 272 | US9855269, Compou...)
Affinity DataKi:  10.7nM IC50:  12.1nMAssay Description:Z'Lyte AssayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM225896(MAP15 | US9592235, Example 272 | US9855269, Compou...)
Affinity DataKi:  10.7nM IC50:  12.1nMAssay Description:Z'Lyte AssayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM225887(DT2012-0355237, MAP05)
Affinity DataKi:  13.6nM IC50:  10.2nMAssay Description:Z'Lyte AssayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM225891(MAP09)
Affinity DataKi:  32.5nM IC50:  21.5nMAssay Description:Z'Lyte AssayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM225895(MAP14 | US9592235, Example 192 | US9855269, Compou...)
Affinity DataKi:  75.5nM IC50:  88.4nMAssay Description:Z'Lyte AssayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM225898(MAP16 | US9592235, Example 248 | US9855269, Compou...)
Affinity DataKi:  78.3nM IC50:  65.7nMAssay Description:Z'Lyte AssayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM225890(MAP08)
Affinity DataKi:  95.4nM IC50:  101nMAssay Description:Z'Lyte AssayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM50011564(CHEMBL3262583 | MAP10 | US9592235, Example 158 | U...)
Affinity DataKi:  108nM IC50:  92.7nMAssay Description:Z'Lyte AssayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM225888(MAP06)
Affinity DataKi:  109nM IC50:  76.8nMAssay Description:Z'Lyte AssayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM225900(MAP18)
Affinity DataKi:  148nM IC50:  139nMAssay Description:Z'Lyte AssayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM50463479(CHEMBL4249925)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of MAP4K4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM50463483(CHEMBL4245242)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of MAP4K4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM225894(MAP13)
Affinity DataKi:  2.55E+3nM IC50:  1.74E+3nMAssay Description:Z'Lyte AssayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM225899(MAP17)
Affinity DataKi:  6.50E+3nM IC50:  1.00E+4nMAssay Description:Z'Lyte AssayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM25617(N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carb...)
Affinity DataIC50:  2.80E+3nMAssay Description:Enzyme activity was assayed using Z-LYTE Enzymatic Kinase Assay format (Invitrogen Corp., Carlsbad, CA) according to the manufacturer instructions.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM31085(1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluorom...)
Affinity DataKd:  15nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataKd:  90nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM25118((3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,...)
Affinity DataKd:  160nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM31088(1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-y...)
Affinity DataKd:  1.30E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Affinity DataKd:  3.10E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM31090((E)-N-[4-(3-chloro-4-fluoro-anilino)-3-cyano-7-eth...)
Affinity DataKd:  330nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM31094(PKC-412 | cid_24202429)
Affinity DataKd:  650nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM13336(4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-...)
Affinity DataKd:  3.70E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd:  260nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataKd:  4.80E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM31096(CHEMBL290084 | Staurosporine | cid_451705)
Affinity DataKd:  24nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Affinity DataKd:  140nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKd:  2.40E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM21(CHEMBL24828 | N-(4-bromo-2-fluorophenyl)-6-methoxy...)
Affinity DataKd:  1.40E+3nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM103302(SCH772984 | US8546404, 6)
Affinity DataIC50:  503nMAssay Description:The IC50 values of selected kinases were determined using either Z'LYTE, Adapta or LanthaScreen assays.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM225230(EED226 | US11013745, Compound EED226)
Affinity DataIC50: >1.00E+4nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM225884(MAP01)
Affinity DataIC50:  3.79nMAssay Description:Z'Lyte AssayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM50354357(CHEMBL1836471 | DT2000-0142665, MAP03)
Affinity DataIC50:  2.25E+3nMAssay Description:Z'Lyte AssayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM225886(MAP04)
Affinity DataIC50:  1.00E+3nMAssay Description:Z'Lyte AssayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM225892(MAP11)
Affinity DataIC50:  22.5nMAssay Description:Z'Lyte AssayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM50011534(CHEMBL3262585)
Affinity DataIC50:  5.84E+3nMAssay Description:Inhibition of human MAP4K4 using 5-FAM-LGRDKYKTLRQIRQ-COOH as substrate by Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM50011535(CHEMBL3262586)
Affinity DataIC50:  2.12E+3nMAssay Description:Inhibition of human MAP4K4 using 5-FAM-LGRDKYKTLRQIRQ-COOH as substrate by Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM50011536(CHEMBL3262587 | US9592235, Example 184 | US9855269...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human MAP4K4 using 5-FAM-LGRDKYKTLRQIRQ-COOH as substrate by Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM50011537(CHEMBL3262562)
Affinity DataKd:  2.20E+5nMAssay Description:Binding affinity to N-terminal His-tagged C-terminal Avi-tagged MAP4K4 (unknown origin) expressed in baculovirus expression system by surface plasmon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM50011539(CHEMBL3262563)
Affinity DataKd:  3.51E+5nMAssay Description:Binding affinity to N-terminal His-tagged C-terminal Avi-tagged MAP4K4 (unknown origin) expressed in baculovirus expression system by surface plasmon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM50011540(CHEMBL3262564)
Affinity DataKd:  6.50E+4nMAssay Description:Binding affinity to N-terminal His-tagged C-terminal Avi-tagged MAP4K4 (unknown origin) expressed in baculovirus expression system by surface plasmon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM50011546(CHEMBL3262565)
Affinity DataKd:  2.80E+4nMAssay Description:Binding affinity to N-terminal His-tagged C-terminal Avi-tagged MAP4K4 (unknown origin) expressed in baculovirus expression system by surface plasmon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM50011547(CHEMBL3262566)
Affinity DataKd:  1.75E+5nMAssay Description:Binding affinity to N-terminal His-tagged C-terminal Avi-tagged MAP4K4 (unknown origin) expressed in baculovirus expression system by surface plasmon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM50011548(CHEMBL3262567)
Affinity DataKd:  6.80E+4nMAssay Description:Binding affinity to N-terminal His-tagged C-terminal Avi-tagged MAP4K4 (unknown origin) expressed in baculovirus expression system by surface plasmon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM50011549(CHEMBL3262568)
Affinity DataKd:  5.10E+5nMAssay Description:Binding affinity to N-terminal His-tagged C-terminal Avi-tagged MAP4K4 (unknown origin) expressed in baculovirus expression system by surface plasmon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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