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Found 1278 hits Enz. Inhib. hit(s) with Target = 'Monoamine Oxidase Type A (MAO-A)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM19163
PNG
(3-methyl-5H-indeno[1,2-c]pyridazin-5-one | Aza-het...)
Show SMILES Cc1cc2C(=O)c3ccccc3-c2nn1
Show InChI InChI=1S/C12H8N2O/c1-7-6-10-11(14-13-7)8-4-2-3-5-9(8)12(10)15/h2-6H,1H3
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n/an/a>1.00E+5n/an/an/an/a7.437



University of Bari



Assay Description
A continuous spectrophotometric assay that monitors the rate of oxidation of the nonselective MAO substrate kynuramine into 4-hydroxyquinoline was us...


J Med Chem 50: 5364-71 (2007)


Article DOI: 10.1021/jm070728r
BindingDB Entry DOI: 10.7270/Q2JD4V2G
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM36553
PNG
(Prochelators, 3)
Show SMILES CCN(C)C(=O)Oc1ccc(CN(C)CC#C)c2cccnc12
Show InChI InChI=1S/C18H21N3O2/c1-5-12-20(3)13-14-9-10-16(23-18(22)21(4)6-2)17-15(14)8-7-11-19-17/h1,7-11H,6,12-13H2,2-4H3
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PubMed
n/an/a 9.60n/an/an/an/a7.437



The Weizmann Institute of Science



Assay Description
Inhibition of MAO activity in rat brain homogenates.


ACS Chem Biol 5: 603-10 (2010)


Article DOI: 10.1021/cb900264w
BindingDB Entry DOI: 10.7270/Q2959FX1
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM19165
PNG
(3-phenyl-5H-indeno[1,2-c]pyridazine | Aza-heterocy...)
Show SMILES C1c2ccccc2-c2nnc(cc12)-c1ccccc1
Show InChI InChI=1S/C17H12N2/c1-2-6-12(7-3-1)16-11-14-10-13-8-4-5-9-15(13)17(14)19-18-16/h1-9,11H,10H2
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n/an/a>1.00E+5n/an/an/an/a7.437



University of Bari



Assay Description
A continuous spectrophotometric assay that monitors the rate of oxidation of the nonselective MAO substrate kynuramine into 4-hydroxyquinoline was us...


J Med Chem 50: 5364-71 (2007)


Article DOI: 10.1021/jm070728r
BindingDB Entry DOI: 10.7270/Q2JD4V2G
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM19166
PNG
(3-phenyl-5H-pyridazino[4,3-b]indole | Aza-heterocy...)
Show SMILES c1ccc(cc1)-c1cc2[nH]c3ccccc3c2nn1
Show InChI InChI=1S/C16H11N3/c1-2-6-11(7-3-1)14-10-15-16(19-18-14)12-8-4-5-9-13(12)17-15/h1-10,17H
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n/an/an/an/an/an/an/a7.437



University of Bari



Assay Description
A continuous spectrophotometric assay that monitors the rate of oxidation of the nonselective MAO substrate kynuramine into 4-hydroxyquinoline was us...


J Med Chem 50: 5364-71 (2007)


Article DOI: 10.1021/jm070728r
BindingDB Entry DOI: 10.7270/Q2JD4V2G
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM19167
PNG
(3-(phenoxymethyl)-5H-indeno[1,2-c]pyridazin-5-one ...)
Show SMILES O=C1c2ccccc2-c2nnc(COc3ccccc3)cc12
Show InChI InChI=1S/C18H12N2O2/c21-18-15-9-5-4-8-14(15)17-16(18)10-12(19-20-17)11-22-13-6-2-1-3-7-13/h1-10H,11H2
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n/an/an/an/an/an/an/a7.437



University of Bari



Assay Description
A continuous spectrophotometric assay that monitors the rate of oxidation of the nonselective MAO substrate kynuramine into 4-hydroxyquinoline was us...


J Med Chem 50: 5364-71 (2007)


Article DOI: 10.1021/jm070728r
BindingDB Entry DOI: 10.7270/Q2JD4V2G
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM19168
PNG
(3-(4-fluorophenoxymethyl)-5H-indeno[1,2-c]pyridazi...)
Show SMILES Fc1ccc(OCc2cc3C(=O)c4ccccc4-c3nn2)cc1
Show InChI InChI=1S/C18H11FN2O2/c19-11-5-7-13(8-6-11)23-10-12-9-16-17(21-20-12)14-3-1-2-4-15(14)18(16)22/h1-9H,10H2
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n/an/an/an/an/an/an/a7.437



University of Bari



Assay Description
A continuous spectrophotometric assay that monitors the rate of oxidation of the nonselective MAO substrate kynuramine into 4-hydroxyquinoline was us...


J Med Chem 50: 5364-71 (2007)


Article DOI: 10.1021/jm070728r
BindingDB Entry DOI: 10.7270/Q2JD4V2G
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM19169
PNG
(3-[4-(trifluoromethyl)phenoxymethyl]-5H-indeno[1,2...)
Show SMILES FC(F)(F)c1ccc(OCc2cc3C(=O)c4ccccc4-c3nn2)cc1
Show InChI InChI=1S/C19H11F3N2O2/c20-19(21,22)11-5-7-13(8-6-11)26-10-12-9-16-17(24-23-12)14-3-1-2-4-15(14)18(16)25/h1-9H,10H2
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n/an/an/an/an/an/an/a7.437



University of Bari



Assay Description
A continuous spectrophotometric assay that monitors the rate of oxidation of the nonselective MAO substrate kynuramine into 4-hydroxyquinoline was us...


J Med Chem 50: 5364-71 (2007)


Article DOI: 10.1021/jm070728r
BindingDB Entry DOI: 10.7270/Q2JD4V2G
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM19170
PNG
(3-(benzyloxy)-5H-indeno[1,2-c]pyridazin-5-one | Az...)
Show SMILES O=C1c2ccccc2-c2nnc(OCc3ccccc3)cc12
Show InChI InChI=1S/C18H12N2O2/c21-18-14-9-5-4-8-13(14)17-15(18)10-16(19-20-17)22-11-12-6-2-1-3-7-12/h1-10H,11H2
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n/an/a>1.00E+5n/an/an/an/a7.437



University of Bari



Assay Description
A continuous spectrophotometric assay that monitors the rate of oxidation of the nonselective MAO substrate kynuramine into 4-hydroxyquinoline was us...


J Med Chem 50: 5364-71 (2007)


Article DOI: 10.1021/jm070728r
BindingDB Entry DOI: 10.7270/Q2JD4V2G
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM19171
PNG
(4-phenyl-5H-indeno[1,2-c]pyridazin-5-one | Aza-het...)
Show SMILES O=C1c2ccccc2-c2nncc(c12)-c1ccccc1
Show InChI InChI=1S/C17H10N2O/c20-17-13-9-5-4-8-12(13)16-15(17)14(10-18-19-16)11-6-2-1-3-7-11/h1-10H
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n/an/a 3.43E+4n/an/an/an/a7.437



University of Bari



Assay Description
A continuous spectrophotometric assay that monitors the rate of oxidation of the nonselective MAO substrate kynuramine into 4-hydroxyquinoline was us...


J Med Chem 50: 5364-71 (2007)


Article DOI: 10.1021/jm070728r
BindingDB Entry DOI: 10.7270/Q2JD4V2G
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM19172
PNG
(4-(4-chlorophenyl)-5H-indeno[1,2-c]pyridazin-5-one...)
Show SMILES Clc1ccc(cc1)-c1cnnc2-c3ccccc3C(=O)c12
Show InChI InChI=1S/C17H9ClN2O/c18-11-7-5-10(6-8-11)14-9-19-20-16-12-3-1-2-4-13(12)17(21)15(14)16/h1-9H
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n/an/a 3.08E+4n/an/an/an/a7.437



University of Bari



Assay Description
A continuous spectrophotometric assay that monitors the rate of oxidation of the nonselective MAO substrate kynuramine into 4-hydroxyquinoline was us...


J Med Chem 50: 5364-71 (2007)


Article DOI: 10.1021/jm070728r
BindingDB Entry DOI: 10.7270/Q2JD4V2G
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM19173
PNG
(2-phenyl-2H,3H,5H-indeno[1,2-c]pyridazine-3,5-dion...)
Show SMILES O=C1c2ccccc2-c2nn(-c3ccccc3)c(=O)cc12
Show InChI InChI=1S/C17H10N2O2/c20-15-10-14-16(12-8-4-5-9-13(12)17(14)21)18-19(15)11-6-2-1-3-7-11/h1-10H
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n/an/an/an/an/an/an/a7.437



University of Bari



Assay Description
A continuous spectrophotometric assay that monitors the rate of oxidation of the nonselective MAO substrate kynuramine into 4-hydroxyquinoline was us...


J Med Chem 50: 5364-71 (2007)


Article DOI: 10.1021/jm070728r
BindingDB Entry DOI: 10.7270/Q2JD4V2G
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM19174
PNG
(2-methyl-9H-indeno[2,1-d]pyrimidin-9-one | Aza-het...)
Show SMILES Cc1ncc2-c3ccccc3C(=O)c2n1
Show InChI InChI=1S/C12H8N2O/c1-7-13-6-10-8-4-2-3-5-9(8)12(15)11(10)14-7/h2-6H,1H3
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n/an/a 4.71E+4n/an/an/an/a7.437



University of Bari



Assay Description
A continuous spectrophotometric assay that monitors the rate of oxidation of the nonselective MAO substrate kynuramine into 4-hydroxyquinoline was us...


J Med Chem 50: 5364-71 (2007)


Article DOI: 10.1021/jm070728r
BindingDB Entry DOI: 10.7270/Q2JD4V2G
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM19175
PNG
(2-phenyl-9H-indeno[2,1-d]pyrimidin-9-one | Aza-het...)
Show SMILES O=C1c2ccccc2-c2cnc(nc12)-c1ccccc1
Show InChI InChI=1S/C17H10N2O/c20-16-13-9-5-4-8-12(13)14-10-18-17(19-15(14)16)11-6-2-1-3-7-11/h1-10H
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n/an/a 2.37E+3n/an/an/an/a7.437



University of Bari



Assay Description
A continuous spectrophotometric assay that monitors the rate of oxidation of the nonselective MAO substrate kynuramine into 4-hydroxyquinoline was us...


J Med Chem 50: 5364-71 (2007)


Article DOI: 10.1021/jm070728r
BindingDB Entry DOI: 10.7270/Q2JD4V2G
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM19176
PNG
(2-phenyl-9H-indeno[2,1-d]pyrimidine | Aza-heterocy...)
Show SMILES c1c2ccccc2c2c[nH]c(nc12)-c1ccccc1
Show InChI InChI=1S/C17H12N2/c1-2-6-12(7-3-1)17-18-11-15-14-9-5-4-8-13(14)10-16(15)19-17/h1-11H,(H,18,19)
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n/an/a 1.67E+4n/an/an/an/a7.437



University of Bari



Assay Description
A continuous spectrophotometric assay that monitors the rate of oxidation of the nonselective MAO substrate kynuramine into 4-hydroxyquinoline was us...


J Med Chem 50: 5364-71 (2007)


Article DOI: 10.1021/jm070728r
BindingDB Entry DOI: 10.7270/Q2JD4V2G
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM19177
PNG
(2-(3-nitrophenyl)-9H-indeno[2,1-d]pyrimidin-9-one ...)
Show SMILES [O-][N+](=O)c1cccc(c1)-c1ncc2-c3ccccc3C(=O)c2n1
Show InChI InChI=1S/C17H9N3O3/c21-16-13-7-2-1-6-12(13)14-9-18-17(19-15(14)16)10-4-3-5-11(8-10)20(22)23/h1-9H
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n/an/an/an/an/an/an/a7.437



University of Bari



Assay Description
A continuous spectrophotometric assay that monitors the rate of oxidation of the nonselective MAO substrate kynuramine into 4-hydroxyquinoline was us...


J Med Chem 50: 5364-71 (2007)


Article DOI: 10.1021/jm070728r
BindingDB Entry DOI: 10.7270/Q2JD4V2G
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM19178
PNG
(2-phenyl-5H-indeno[1,2-d]pyrimidin-5-one | Aza-het...)
Show SMILES O=C1c2ccccc2-c2nc(ncc12)-c1ccccc1
Show InChI InChI=1S/C17H10N2O/c20-16-13-9-5-4-8-12(13)15-14(16)10-18-17(19-15)11-6-2-1-3-7-11/h1-10H
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n/an/a 8.39E+3n/an/an/an/a7.437



University of Bari



Assay Description
A continuous spectrophotometric assay that monitors the rate of oxidation of the nonselective MAO substrate kynuramine into 4-hydroxyquinoline was us...


J Med Chem 50: 5364-71 (2007)


Article DOI: 10.1021/jm070728r
BindingDB Entry DOI: 10.7270/Q2JD4V2G
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM19179
PNG
(2-phenyl-5H-indeno[1,2-d]pyrimidine | Aza-heterocy...)
Show SMILES C1c2ccccc2-c2nc(ncc12)-c1ccccc1
Show InChI InChI=1S/C17H12N2/c1-2-6-12(7-3-1)17-18-11-14-10-13-8-4-5-9-15(13)16(14)19-17/h1-9,11H,10H2
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n/an/a 1.80E+4n/an/an/an/a7.437



University of Bari



Assay Description
A continuous spectrophotometric assay that monitors the rate of oxidation of the nonselective MAO substrate kynuramine into 4-hydroxyquinoline was us...


J Med Chem 50: 5364-71 (2007)


Article DOI: 10.1021/jm070728r
BindingDB Entry DOI: 10.7270/Q2JD4V2G
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM19180
PNG
(4-phenyl-5H-indeno[1,2-d]pyrimidin-5-one | Aza-het...)
Show SMILES O=C1c2ccccc2-c2ncnc(c12)-c1ccccc1
Show InChI InChI=1S/C17H10N2O/c20-17-13-9-5-4-8-12(13)16-14(17)15(18-10-19-16)11-6-2-1-3-7-11/h1-10H
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n/an/a 2.16E+4n/an/an/an/a7.437



University of Bari



Assay Description
A continuous spectrophotometric assay that monitors the rate of oxidation of the nonselective MAO substrate kynuramine into 4-hydroxyquinoline was us...


J Med Chem 50: 5364-71 (2007)


Article DOI: 10.1021/jm070728r
BindingDB Entry DOI: 10.7270/Q2JD4V2G
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM19181
PNG
(3-phenyl-4aH,9H,9aH-indeno[1,2-e][1,2,4]triazin-9-...)
Show SMILES O=C1c2ccccc2-c2nc(nnc12)-c1ccccc1
Show InChI InChI=1S/C16H9N3O/c20-15-12-9-5-4-8-11(12)13-14(15)18-19-16(17-13)10-6-2-1-3-7-10/h1-9H
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n/an/an/an/an/an/an/a7.437



University of Bari



Assay Description
A continuous spectrophotometric assay that monitors the rate of oxidation of the nonselective MAO substrate kynuramine into 4-hydroxyquinoline was us...


J Med Chem 50: 5364-71 (2007)


Article DOI: 10.1021/jm070728r
BindingDB Entry DOI: 10.7270/Q2JD4V2G
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM19182
PNG
(3-(3-aminophenyl)-4aH,9H,9aH-indeno[1,2-e][1,2,4]t...)
Show SMILES Nc1cccc(c1)-c1nnc2C(=O)c3ccccc3-c2n1
Show InChI InChI=1S/C16H10N4O/c17-10-5-3-4-9(8-10)16-18-13-11-6-1-2-7-12(11)15(21)14(13)19-20-16/h1-8H,17H2
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n/an/an/an/an/an/an/a7.437



University of Bari



Assay Description
A continuous spectrophotometric assay that monitors the rate of oxidation of the nonselective MAO substrate kynuramine into 4-hydroxyquinoline was us...


J Med Chem 50: 5364-71 (2007)


Article DOI: 10.1021/jm070728r
BindingDB Entry DOI: 10.7270/Q2JD4V2G
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM19183
PNG
(3-(3-nitrophenyl)-4aH,9H,9aH-indeno[1,2-e][1,2,4]t...)
Show SMILES [O-][N+](=O)c1cccc(c1)-c1nnc2C(=O)c3ccccc3-c2n1
Show InChI InChI=1S/C16H8N4O3/c21-15-12-7-2-1-6-11(12)13-14(15)18-19-16(17-13)9-4-3-5-10(8-9)20(22)23/h1-8H
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n/an/an/an/an/an/an/a7.437



University of Bari



Assay Description
A continuous spectrophotometric assay that monitors the rate of oxidation of the nonselective MAO substrate kynuramine into 4-hydroxyquinoline was us...


J Med Chem 50: 5364-71 (2007)


Article DOI: 10.1021/jm070728r
BindingDB Entry DOI: 10.7270/Q2JD4V2G
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM19184
PNG
(3-(3-nitrophenyl)-4aH,5H,9bH-indeno[2,1-e][1,2,4]t...)
Show SMILES [O-][N+](=O)c1cccc(c1)-c1nnc2-c3ccccc3C(=O)c2n1
Show InChI InChI=1S/C16H8N4O3/c21-15-12-7-2-1-6-11(12)13-14(15)17-16(19-18-13)9-4-3-5-10(8-9)20(22)23/h1-8H
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n/an/an/an/an/an/an/a7.437



University of Bari



Assay Description
A continuous spectrophotometric assay that monitors the rate of oxidation of the nonselective MAO substrate kynuramine into 4-hydroxyquinoline was us...


J Med Chem 50: 5364-71 (2007)


Article DOI: 10.1021/jm070728r
BindingDB Entry DOI: 10.7270/Q2JD4V2G
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM19185
PNG
(8,9,17-triazatetracyclo[8.7.0.0^{2,7}.0^{11,16}]he...)
Show SMILES c1ccc2c(c1)[nH]c1c2nnc2ccccc12
Show InChI InChI=1S/C14H9N3/c1-3-7-11-9(5-1)14-13(15-11)10-6-2-4-8-12(10)16-17-14/h1-8,15H
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n/an/a 2.97E+4n/an/an/an/a7.437



University of Bari



Assay Description
A continuous spectrophotometric assay that monitors the rate of oxidation of the nonselective MAO substrate kynuramine into 4-hydroxyquinoline was us...


J Med Chem 50: 5364-71 (2007)


Article DOI: 10.1021/jm070728r
BindingDB Entry DOI: 10.7270/Q2JD4V2G
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM19186
PNG
(17-azatetracyclo[8.7.0.0^{2,7}.0^{11,16}]heptadeca...)
Show SMILES C1Cc2ccccc2-c2[nH]c3ccccc3c12
Show InChI InChI=1S/C16H13N/c1-2-6-12-11(5-1)9-10-14-13-7-3-4-8-15(13)17-16(12)14/h1-8,17H,9-10H2
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n/an/a 1.20E+4n/an/an/an/a7.437



University of Bari



Assay Description
A continuous spectrophotometric assay that monitors the rate of oxidation of the nonselective MAO substrate kynuramine into 4-hydroxyquinoline was us...


J Med Chem 50: 5364-71 (2007)


Article DOI: 10.1021/jm070728r
BindingDB Entry DOI: 10.7270/Q2JD4V2G
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM36552
PNG
(Prochelators, 2)
Show SMILES CN(CC#C)Cc1ccc(OC(=O)N(C)C)c2ncccc12
Show InChI InChI=1S/C17H19N3O2/c1-5-11-20(4)12-13-8-9-15(22-17(21)19(2)3)16-14(13)7-6-10-18-16/h1,6-10H,11-12H2,2-4H3
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n/an/a 7.70n/an/an/an/a7.437



The Weizmann Institute of Science



Assay Description
Inhibition of MAO activity in rat brain homogenates.


ACS Chem Biol 5: 603-10 (2010)


Article DOI: 10.1021/cb900264w
BindingDB Entry DOI: 10.7270/Q2959FX1
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM19164
PNG
(3-phenyl-5H-indeno[1,2-c]pyridazin-5-one | Aza-het...)
Show SMILES O=C1c2ccccc2-c2nnc(cc12)-c1ccccc1
Show InChI InChI=1S/C17H10N2O/c20-17-13-9-5-4-8-12(13)16-14(17)10-15(18-19-16)11-6-2-1-3-7-11/h1-10H
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n/an/an/an/an/an/an/a7.437



University of Bari



Assay Description
A continuous spectrophotometric assay that monitors the rate of oxidation of the nonselective MAO substrate kynuramine into 4-hydroxyquinoline was us...


J Med Chem 50: 5364-71 (2007)


Article DOI: 10.1021/jm070728r
BindingDB Entry DOI: 10.7270/Q2JD4V2G
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM50087809
PNG
(CHEMBL298006 | Methyl-(1-methyl-1H-indol-2-ylmethy...)
Show SMILES CN(CC#C)Cc1cc2ccccc2n1C
Show InChI InChI=1S/C14H16N2/c1-4-9-15(2)11-13-10-12-7-5-6-8-14(12)16(13)3/h1,5-8,10H,9,11H2,2-3H3
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0.300n/an/an/an/an/an/an/an/a



Universitat Autònoma de Barcelona

Curated by ChEMBL


Assay Description
Inhibitory activity against Monoamine oxidase A


J Med Chem 43: 1684-91 (2000)


Article DOI: 10.1021/jm991164x
BindingDB Entry DOI: 10.7270/Q2C53K38
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM50087796
PNG
((5-Methoxy-1-methyl-1H-indol-2-ylmethyl)-prop-2-yn...)
Show SMILES COc1ccc2n(C)c(CNCC#C)cc2c1
Show InChI InChI=1S/C14H16N2O/c1-4-7-15-10-12-8-11-9-13(17-3)5-6-14(11)16(12)2/h1,5-6,8-9,15H,7,10H2,2-3H3
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0.800n/an/an/an/an/an/an/an/a



Universitat Autònoma de Barcelona

Curated by ChEMBL


Assay Description
Inhibitory activity against Monoamine oxidase A


J Med Chem 43: 1684-91 (2000)


Article DOI: 10.1021/jm991164x
BindingDB Entry DOI: 10.7270/Q2C53K38
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM50087791
PNG
(But-2-ynyl-(5-methoxy-1-methyl-1H-indol-2-ylmethyl...)
Show SMILES COc1ccc2n(C)c(CN(C)CC#CC)cc2c1
Show InChI InChI=1S/C16H20N2O/c1-5-6-9-17(2)12-14-10-13-11-15(19-4)7-8-16(13)18(14)3/h7-8,10-11H,9,12H2,1-4H3
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1.40n/an/an/an/an/an/an/an/a



Universitat Autònoma de Barcelona

Curated by ChEMBL


Assay Description
Inhibitory activity against Monoamine oxidase A


J Med Chem 43: 1684-91 (2000)


Article DOI: 10.1021/jm991164x
BindingDB Entry DOI: 10.7270/Q2C53K38
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM50087801
PNG
((5-Methoxy-1-methyl-1H-indol-2-ylmethyl)-methyl-pr...)
Show SMILES COc1ccc2n(C)c(CN(C)CC#C)cc2c1
Show InChI InChI=1S/C15H18N2O/c1-5-8-16(2)11-13-9-12-10-14(18-4)6-7-15(12)17(13)3/h1,6-7,9-10H,8,11H2,2-4H3
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1.5n/an/an/an/an/an/an/an/a



Universitat Autònoma de Barcelona

Curated by ChEMBL


Assay Description
Inhibitory activity against Monoamine oxidase A


J Med Chem 43: 1684-91 (2000)


Article DOI: 10.1021/jm991164x
BindingDB Entry DOI: 10.7270/Q2C53K38
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM50168981
PNG
(1-(1-Methyl-1H-pyrrol-2-yl)-2-phenyl-2-pyrrolidin-...)
Show SMILES Cn1cccc1C(=O)[C@H](N1CCCC1)c1ccccc1
Show InChI InChI=1S/C17H20N2O/c1-18-11-7-10-15(18)17(20)16(19-12-5-6-13-19)14-8-3-2-4-9-14/h2-4,7-11,16H,5-6,12-13H2,1H3/t16-/m1/s1
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3.5n/an/an/an/an/an/an/an/a



Università di Roma La Sapienza

Curated by ChEMBL


Assay Description
Inhibtory concentration for rat Monoamine oxidase A


J Med Chem 48: 4220-3 (2005)


Article DOI: 10.1021/jm050172c
BindingDB Entry DOI: 10.7270/Q2862FZV
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM50087803
PNG
(1-Methyl-2-[(methyl-prop-2-ynyl-amino)-methyl]-1H-...)
Show SMILES CN(CC#C)Cc1cc2cc(O)ccc2n1C
Show InChI InChI=1S/C14H16N2O/c1-4-7-15(2)10-12-8-11-9-13(17)5-6-14(11)16(12)3/h1,5-6,8-9,17H,7,10H2,2-3H3
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4n/an/an/an/an/an/an/an/a



Universitat Autònoma de Barcelona

Curated by ChEMBL


Assay Description
Inhibitory activity against Monoamine oxidase A


J Med Chem 43: 1684-91 (2000)


Article DOI: 10.1021/jm991164x
BindingDB Entry DOI: 10.7270/Q2C53K38
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM50049679
PNG
(6-(4,5-Dihydro-1H-imidazol-2-yl)-2-ethyl-10,10-dio...)
Show SMILES CCc1ccc2c(c1)C(=O)c1ccc(cc1S2(=O)=O)C1=NCCN1
Show InChI InChI=1S/C18H16N2O3S/c1-2-11-3-6-15-14(9-11)17(21)13-5-4-12(18-19-7-8-20-18)10-16(13)24(15,22)23/h3-6,9-10H,2,7-8H2,1H3,(H,19,20)
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4n/an/an/an/an/an/an/an/a



Wellcome Research Laboratories

Curated by ChEMBL


Assay Description
Ex vivo value for inhibition of MAO A of rats sacrificed 2 hr after po administration


J Med Chem 39: 1857-63 (1996)


Article DOI: 10.1021/jm950595m
BindingDB Entry DOI: 10.7270/Q2TM796B
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM50304156
PNG
(3-(2-Furyl)-2-(N-phenyllthiocarbamoyl)-3,3a,4,5,6,...)
Show SMILES S=C(Nc1ccccc1)N1N=C2CCCCC2C1c1ccco1
Show InChI InChI=1S/C18H19N3OS/c23-18(19-13-7-2-1-3-8-13)21-17(16-11-6-12-22-16)14-9-4-5-10-15(14)20-21/h1-3,6-8,11-12,14,17H,4-5,9-10H2,(H,19,23)
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4.22n/an/an/an/an/an/an/an/a



Hacettepe University

Curated by ChEMBL


Assay Description
Competitive inhibition of MAOA in rat liver homogenate by spectrophotometrically


Bioorg Med Chem 17: 6761-72 (2009)


Article DOI: 10.1016/j.bmc.2009.07.033
BindingDB Entry DOI: 10.7270/Q2TQ61M2
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM50087794
PNG
(But-2-ynyl-methyl-(1-methyl-1H-indol-2-ylmethyl)-a...)
Show SMILES CC#CCN(C)Cc1cc2ccccc2n1C
Show InChI InChI=1S/C15H18N2/c1-4-5-10-16(2)12-14-11-13-8-6-7-9-15(13)17(14)3/h6-9,11H,10,12H2,1-3H3
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4.30n/an/an/an/an/an/an/an/a



Universitat Autònoma de Barcelona

Curated by ChEMBL


Assay Description
Inhibitory activity against Monoamine oxidase A


J Med Chem 43: 1684-91 (2000)


Article DOI: 10.1021/jm991164x
BindingDB Entry DOI: 10.7270/Q2C53K38
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM15613
PNG
(4-chloro-N-(2-morpholin-4-ylethyl)benzamide | 4-ch...)
Show SMILES Clc1ccc(cc1)C(=O)NCCN1CCOCC1
Show InChI InChI=1S/C13H17ClN2O2/c14-12-3-1-11(2-4-12)13(17)15-5-6-16-7-9-18-10-8-16/h1-4H,5-10H2,(H,15,17)
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5n/an/an/an/an/an/an/an/a



Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of MAO-A in rat liver homogenate by spectrophotometry-based Holt method


Bioorg Med Chem Lett 20: 132-6 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.015
BindingDB Entry DOI: 10.7270/Q2F76CPV
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM15613
PNG
(4-chloro-N-(2-morpholin-4-ylethyl)benzamide | 4-ch...)
Show SMILES Clc1ccc(cc1)C(=O)NCCN1CCOCC1
Show InChI InChI=1S/C13H17ClN2O2/c14-12-3-1-11(2-4-12)13(17)15-5-6-16-7-9-18-10-8-16/h1-4H,5-10H2,(H,15,17)
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5.53n/an/an/an/an/an/an/an/a



Hacettepe University

Curated by ChEMBL


Assay Description
Competitive inhibition of MAOA in rat liver homogenate by spectrophotometrically


Bioorg Med Chem 17: 6761-72 (2009)


Article DOI: 10.1016/j.bmc.2009.07.033
BindingDB Entry DOI: 10.7270/Q2TQ61M2
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM50087790
PNG
(2-[(But-2-ynyl-methyl-amino)-methyl]-1-methyl-1H-i...)
Show SMILES CC#CCN(C)Cc1cc2cc(O)ccc2n1C
Show InChI InChI=1S/C15H18N2O/c1-4-5-8-16(2)11-13-9-12-10-14(18)6-7-15(12)17(13)3/h6-7,9-10,18H,8,11H2,1-3H3
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5.70n/an/an/an/an/an/an/an/a



Universitat Autònoma de Barcelona

Curated by ChEMBL


Assay Description
Inhibitory activity against Monoamine oxidase A


J Med Chem 43: 1684-91 (2000)


Article DOI: 10.1021/jm991164x
BindingDB Entry DOI: 10.7270/Q2C53K38
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM50168986
PNG
(1-(1-Methyl-1H-pyrrol-2-yl)-2-piperidin-1-yl-ethan...)
Show SMILES Cn1cccc1C(=O)CN1CCCCC1
Show InChI InChI=1S/C12H18N2O/c1-13-7-5-6-11(13)12(15)10-14-8-3-2-4-9-14/h5-7H,2-4,8-10H2,1H3
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7n/an/an/an/an/an/an/an/a



Università di Roma La Sapienza

Curated by ChEMBL


Assay Description
Inhibtory concentration for rat Monoamine oxidase A


J Med Chem 48: 4220-3 (2005)


Article DOI: 10.1021/jm050172c
BindingDB Entry DOI: 10.7270/Q2862FZV
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM50168987
PNG
(1-(1-Methyl-1H-pyrrol-2-yl)-2-phenyl-2-pyrrolidin-...)
Show SMILES Cn1cccc1C(=O)C(N1CCCC1)c1ccccc1
Show InChI InChI=1S/C17H20N2O/c1-18-11-7-10-15(18)17(20)16(19-12-5-6-13-19)14-8-3-2-4-9-14/h2-4,7-11,16H,5-6,12-13H2,1H3
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7.5n/an/an/an/an/an/an/an/a



Università di Roma La Sapienza

Curated by ChEMBL


Assay Description
Inhibtory concentration for rat Monoamine oxidase A


J Med Chem 48: 4220-3 (2005)


Article DOI: 10.1021/jm050172c
BindingDB Entry DOI: 10.7270/Q2862FZV
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM50168984
PNG
(1-(1-Methyl-1H-pyrrol-2-yl)-2-phenyl-2-pyrrolidin-...)
Show SMILES Cn1cccc1C(=O)[C@@H](N1CCCC1)c1ccccc1
Show InChI InChI=1S/C17H20N2O/c1-18-11-7-10-15(18)17(20)16(19-12-5-6-13-19)14-8-3-2-4-9-14/h2-4,7-11,16H,5-6,12-13H2,1H3/t16-/m0/s1
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9.5n/an/an/an/an/an/an/an/a



Università di Roma La Sapienza

Curated by ChEMBL


Assay Description
Inhibtory concentration for rat Monoamine oxidase A


J Med Chem 48: 4220-3 (2005)


Article DOI: 10.1021/jm050172c
BindingDB Entry DOI: 10.7270/Q2862FZV
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM50168982
PNG
(1-(1-Methyl-1H-pyrrol-2-yl)-2-phenyl-2-piperidin-1...)
Show SMILES Cn1cccc1C(=O)[C@H](N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C18H22N2O/c1-19-12-8-11-16(19)18(21)17(15-9-4-2-5-10-15)20-13-6-3-7-14-20/h2,4-5,8-12,17H,3,6-7,13-14H2,1H3/t17-/m1/s1
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10n/an/an/an/an/an/an/an/a



Università di Roma La Sapienza

Curated by ChEMBL


Assay Description
Inhibtory concentration for rat Monoamine oxidase A


J Med Chem 48: 4220-3 (2005)


Article DOI: 10.1021/jm050172c
BindingDB Entry DOI: 10.7270/Q2862FZV
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM50009741
PNG
(1-Ethyl-phenoxathiine 10,10-dioxide | CHEMBL66225)
Show SMILES CCc1cccc2Oc3ccccc3S(=O)(=O)c12
Show InChI InChI=1S/C14H12O3S/c1-2-10-6-5-8-12-14(10)18(15,16)13-9-4-3-7-11(13)17-12/h3-9H,2H2,1H3
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10n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
In vitro binding affinity of the compound towards Monoamine Oxidase A in rat


J Med Chem 34: 2931-3 (1991)


Article DOI: 10.1021/jm00113a039
BindingDB Entry DOI: 10.7270/Q28S4NW2
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM50401404
PNG
(CHEMBL2207498)
Show SMILES CCCN1CCC(CC1)c1cc2ccccc2s1
Show InChI InChI=1S/C16H21NS/c1-2-9-17-10-7-13(8-11-17)16-12-14-5-3-4-6-15(14)18-16/h3-6,12-13H,2,7-11H2,1H3
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18n/an/an/an/an/an/an/an/a



NeuroSearch Sweden AB

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 41-1049 from MAO-A in rat cerebral cortex by competition binding assay


J Med Chem 55: 9735-50 (2012)


Article DOI: 10.1021/jm300975f
BindingDB Entry DOI: 10.7270/Q26974RR
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM50341152
PNG
(3-(anthracen-9-yl)-5-(4-nitrophenyl)-4,5-dihydro-1...)
Show SMILES [O-][N+](=O)c1ccc(cc1)C1CC(N=N1)c1c2ccccc2cc2ccccc12
Show InChI InChI=1S/C23H17N3O2/c27-26(28)18-11-9-15(10-12-18)21-14-22(25-24-21)23-19-7-3-1-5-16(19)13-17-6-2-4-8-20(17)23/h1-13,21-22H,14H2
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20.1n/an/an/an/an/an/an/an/a



Birla Institute of Technology

Curated by ChEMBL


Assay Description
Competitive inhibition of rat liver MAO-A after 60 mins using p-tyramine as substrate by spectrophotometry


Bioorg Med Chem Lett 21: 1969-73 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.030
BindingDB Entry DOI: 10.7270/Q2JM29XC
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM50168983
PNG
(1-(1-Methyl-1H-pyrrol-2-yl)-2-piperidin-1-yl-propa...)
Show SMILES CC(N1CCCCC1)C(=O)c1cccn1C
Show InChI InChI=1S/C13H20N2O/c1-11(15-9-4-3-5-10-15)13(16)12-7-6-8-14(12)2/h6-8,11H,3-5,9-10H2,1-2H3
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38n/an/an/an/an/an/an/an/a



Università di Roma La Sapienza

Curated by ChEMBL


Assay Description
Inhibtory concentration for rat Monoamine oxidase A


J Med Chem 48: 4220-3 (2005)


Article DOI: 10.1021/jm050172c
BindingDB Entry DOI: 10.7270/Q2862FZV
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM50304161
PNG
(3-(2-Thienyl)-2-(N-phenylthiocarbamoyl)-3,3a,4,5,6...)
Show SMILES S=C(Nc1ccccc1)N1N=C2CCCCC2C1c1cccs1
Show InChI InChI=1S/C18H19N3S2/c22-18(19-13-7-2-1-3-8-13)21-17(16-11-6-12-23-16)14-9-4-5-10-15(14)20-21/h1-3,6-8,11-12,14,17H,4-5,9-10H2,(H,19,22)
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39.1n/an/an/an/an/an/an/an/a



Hacettepe University

Curated by ChEMBL


Assay Description
Competitive inhibition of MAOA in rat liver homogenate by spectrophotometrically


Bioorg Med Chem 17: 6761-72 (2009)


Article DOI: 10.1016/j.bmc.2009.07.033
BindingDB Entry DOI: 10.7270/Q2TQ61M2
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM50341160
PNG
(3-(anthracen-9-yl)-5-(3-nitrophenyl)-4,5-dihydro-1...)
Show SMILES [O-][N+](=O)c1cccc(c1)C1CC(N=N1)c1c2ccccc2cc2ccccc12
Show InChI InChI=1S/C23H17N3O2/c27-26(28)18-9-5-8-17(13-18)21-14-22(25-24-21)23-19-10-3-1-6-15(19)12-16-7-2-4-11-20(16)23/h1-13,21-22H,14H2
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43.9n/an/an/an/an/an/an/an/a



Birla Institute of Technology

Curated by ChEMBL


Assay Description
Competitive inhibition of rat liver MAO-A after 60 mins using p-tyramine as substrate by spectrophotometry


Bioorg Med Chem Lett 21: 1969-73 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.030
BindingDB Entry DOI: 10.7270/Q2JM29XC
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM50213676
PNG
((S)-2-amino-1-(4-ethylthiophenyl)-propane | CHEMBL...)
Show SMILES CCSc1ccc(C[C@H](C)N)cc1
Show InChI InChI=1S/C11H17NS/c1-3-13-11-6-4-10(5-7-11)8-9(2)12/h4-7,9H,3,8,12H2,1-2H3/t9-/m0/s1
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54n/an/an/an/an/an/an/an/a



University of Santiago de Chile

Curated by ChEMBL


Assay Description
Inhibition of rat brain MAOA


Bioorg Med Chem 15: 5198-206 (2007)


Article DOI: 10.1016/j.bmc.2007.05.021
BindingDB Entry DOI: 10.7270/Q2DN44RX
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM50401405
PNG
(CHEMBL2207497)
Show SMILES CCCN1CCC(CC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C18H23N/c1-2-11-19-12-9-16(10-13-19)18-8-7-15-5-3-4-6-17(15)14-18/h3-8,14,16H,2,9-13H2,1H3
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63n/an/an/an/an/an/an/an/a



NeuroSearch Sweden AB

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro 41-1049 from MAO-A in rat cerebral cortex by competition binding assay


J Med Chem 55: 9735-50 (2012)


Article DOI: 10.1021/jm300975f
BindingDB Entry DOI: 10.7270/Q26974RR
More data for this
Ligand-Target Pair
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