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Compile Data Set for Download or QSAR

Found 392 hits Enz. Inhib. hit(s) with Target = 'NMDA receptor subtype 2A protein (NR2A)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM287586
PNG
(US10420768, Compound C-2 | US9567341, Compound C-2)
Show SMILES Fc1ccc(nc1)C(F)(F)CN1CCC(CC1)Nc1ncnc2[nH]ccc12
Show InChI InChI=1S/C18H19F3N6/c19-12-1-2-15(23-9-12)18(20,21)10-27-7-4-13(5-8-27)26-17-14-3-6-22-16(14)24-11-25-17/h1-3,6,9,11,13H,4-5,7-8,10H2,(H2,22,24,25,26)
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n/an/a>1.00E+7n/an/an/an/a7.4n/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
Inhibitory activities of test compounds on 5 major isoforms of CYP P450 were evaluated by using pooled human liver microsome (HLM, purchased from BD ...


US Patent US9567341 (2017)


BindingDB Entry DOI: 10.7270/Q2DN473N
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM287587
PNG
(US10420768, Compound C-3 | US9567341, Compound C-3...)
Show SMILES FC(F)(CN1CCC(CC1)Nc1ncnc2[nH]ccc12)c1ccc(Cl)cn1
Show InChI InChI=1S/C18H19ClF2N6/c19-12-1-2-15(23-9-12)18(20,21)10-27-7-4-13(5-8-27)26-17-14-3-6-22-16(14)24-11-25-17/h1-3,6,9,11,13H,4-5,7-8,10H2,(H2,22,24,25,26)
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n/an/a>1.00E+7n/an/an/an/a7.4n/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
Inhibitory activities of test compounds on 5 major isoforms of CYP P450 were evaluated by using pooled human liver microsome (HLM, purchased from BD ...


US Patent US9567341 (2017)


BindingDB Entry DOI: 10.7270/Q2DN473N
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM287588
PNG
(US10420768, Compound C-4 | US9567341, Compound C-4...)
Show SMILES Cc1ccc(nc1)C(F)(F)CN1CCC(CC1)Nc1ncnc2[nH]ccc12
Show InChI InChI=1S/C19H22F2N6/c1-13-2-3-16(23-10-13)19(20,21)11-27-8-5-14(6-9-27)26-18-15-4-7-22-17(15)24-12-25-18/h2-4,7,10,12,14H,5-6,8-9,11H2,1H3,(H2,22,24,25,26)
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n/an/a>1.00E+7n/an/an/an/a7.4n/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
Inhibitory activities of test compounds on 5 major isoforms of CYP P450 were evaluated by using pooled human liver microsome (HLM, purchased from BD ...


US Patent US9567341 (2017)


BindingDB Entry DOI: 10.7270/Q2DN473N
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM287589
PNG
(US10420768, Compound C-5 | US9567341, Compound C-5...)
Show SMILES FC(F)(F)c1ccc(nc1)C(F)(F)CN1CCC(CC1)Nc1ncnc2[nH]ccc12
Show InChI InChI=1S/C19H19F5N6/c20-18(21,15-2-1-12(9-26-15)19(22,23)24)10-30-7-4-13(5-8-30)29-17-14-3-6-25-16(14)27-11-28-17/h1-3,6,9,11,13H,4-5,7-8,10H2,(H2,25,27,28,29)
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n/an/a>1.00E+7n/an/an/an/a7.4n/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
Inhibitory activities of test compounds on 5 major isoforms of CYP P450 were evaluated by using pooled human liver microsome (HLM, purchased from BD ...


US Patent US9567341 (2017)


BindingDB Entry DOI: 10.7270/Q2DN473N
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM287590
PNG
(US10420768, Compound C-16 | US9567341, Compound C-...)
Show SMILES Fc1cc(Cl)cnc1C(F)(F)CN1CCC(CC1)Nc1ncnc2[nH]ccc12
Show InChI InChI=1S/C18H18ClF3N6/c19-11-7-14(20)15(24-8-11)18(21,22)9-28-5-2-12(3-6-28)27-17-13-1-4-23-16(13)25-10-26-17/h1,4,7-8,10,12H,2-3,5-6,9H2,(H2,23,25,26,27)
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n/an/a>1.00E+7n/an/an/an/a7.4n/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
Inhibitory activities of test compounds on 5 major isoforms of CYP P450 were evaluated by using pooled human liver microsome (HLM, purchased from BD ...


US Patent US9567341 (2017)


BindingDB Entry DOI: 10.7270/Q2DN473N
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM287591
PNG
(US10420768, Compound C-18 | US9567341, Compound C-...)
Show SMILES Fc1cc(cnc1C(F)(F)CN1CCC(CC1)Nc1ncnc2[nH]ccc12)C(F)(F)F
Show InChI InChI=1S/C19H18F6N6/c20-14-7-11(19(23,24)25)8-27-15(14)18(21,22)9-31-5-2-12(3-6-31)30-17-13-1-4-26-16(13)28-10-29-17/h1,4,7-8,10,12H,2-3,5-6,9H2,(H2,26,28,29,30)
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n/an/a>1.00E+7n/an/an/an/a7.4n/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
Inhibitory activities of test compounds on 5 major isoforms of CYP P450 were evaluated by using pooled human liver microsome (HLM, purchased from BD ...


US Patent US9567341 (2017)


BindingDB Entry DOI: 10.7270/Q2DN473N
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM287592
PNG
(US10420768, Compound C-17 | US9567341, Compound C-...)
Show SMILES Cc1cnc(c(F)c1)C(F)(F)CN1CCC(CC1)Nc1ncnc2[nH]ccc12
Show InChI InChI=1S/C19H21F3N6/c1-12-8-15(20)16(24-9-12)19(21,22)10-28-6-3-13(4-7-28)27-18-14-2-5-23-17(14)25-11-26-18/h2,5,8-9,11,13H,3-4,6-7,10H2,1H3,(H2,23,25,26,27)
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n/an/a>1.00E+7n/an/an/an/a7.4n/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
Inhibitory activities of test compounds on 5 major isoforms of CYP P450 were evaluated by using pooled human liver microsome (HLM, purchased from BD ...


US Patent US9567341 (2017)


BindingDB Entry DOI: 10.7270/Q2DN473N
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM287593
PNG
(US10420768, Compound C-47 | US9567341, Compound C-...)
Show SMILES CN(C1CCN(CC(F)(F)c2ccc(C)cn2)CC1)c1ncnc2[nH]ccc12
Show InChI InChI=1S/C20H24F2N6/c1-14-3-4-17(24-11-14)20(21,22)12-28-9-6-15(7-10-28)27(2)19-16-5-8-23-18(16)25-13-26-19/h3-5,8,11,13,15H,6-7,9-10,12H2,1-2H3,(H,23,25,26)
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n/an/a>1.00E+7n/an/an/an/a7.4n/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
Inhibitory activities of test compounds on 5 major isoforms of CYP P450 were evaluated by using pooled human liver microsome (HLM, purchased from BD ...


US Patent US9567341 (2017)


BindingDB Entry DOI: 10.7270/Q2DN473N
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM287594
PNG
(US10420768, Compound C-230 | US9567341, Compound C...)
Show SMILES Cc1cnc(cn1)C(F)(F)CN1CCC(CC1)Nc1ncnc2[nH]ccc12
Show InChI InChI=1S/C18H21F2N7/c1-12-8-23-15(9-22-12)18(19,20)10-27-6-3-13(4-7-27)26-17-14-2-5-21-16(14)24-11-25-17/h2,5,8-9,11,13H,3-4,6-7,10H2,1H3,(H2,21,24,25,26)
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n/an/a>1.00E+7n/an/an/an/a7.4n/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
Inhibitory activities of test compounds on 5 major isoforms of CYP P450 were evaluated by using pooled human liver microsome (HLM, purchased from BD ...


US Patent US9567341 (2017)


BindingDB Entry DOI: 10.7270/Q2DN473N
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM280723
PNG
(N-(1-(2,2-difluoro-2-(pyridin-2-yl)ethyl)piperidin...)
Show SMILES FC(F)(CN1CCC(CC1)Nc1ncnc2[nH]ncc12)c1ccccn1
Show InChI InChI=1S/C17H19F2N7/c18-17(19,14-3-1-2-6-20-14)10-26-7-4-12(5-8-26)24-15-13-9-23-25-16(13)22-11-21-15/h1-3,6,9,11-12H,4-5,7-8,10H2,(H2,21,22,23,24,25)
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n/an/a>1.00E+7n/an/an/an/a7.4n/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
Inhibitory activities of test compounds on 5 major isoforms of CYP P450 were evaluated by using pooled human liver microsome (HLM, purchased from BD ...


US Patent US9567341 (2017)


BindingDB Entry DOI: 10.7270/Q2DN473N
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM287596
PNG
(US10420768, Compound C-127 | US9567341, Compound C...)
Show SMILES FC(F)(F)c1ccc(cn1)C(F)(F)CN1CCC(CC1)Nc1ncnc2[nH]ccc12
Show InChI InChI=1S/C19H19F5N6/c20-18(21,12-1-2-15(26-9-12)19(22,23)24)10-30-7-4-13(5-8-30)29-17-14-3-6-25-16(14)27-11-28-17/h1-3,6,9,11,13H,4-5,7-8,10H2,(H2,25,27,28,29)
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n/an/a>1.00E+7n/an/an/an/a7.4n/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
Inhibitory activities of test compounds on 5 major isoforms of CYP P450 were evaluated by using pooled human liver microsome (HLM, purchased from BD ...


US Patent US9567341 (2017)


BindingDB Entry DOI: 10.7270/Q2DN473N
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM287597
PNG
(US10420768, Compound C-128 | US9567341, Compound C...)
Show SMILES Cc1ccc(cn1)C(F)(F)CN1CCC(CC1)Nc1ncnc2[nH]ccc12
Show InChI InChI=1S/C19H22F2N6/c1-13-2-3-14(10-23-13)19(20,21)11-27-8-5-15(6-9-27)26-18-16-4-7-22-17(16)24-12-25-18/h2-4,7,10,12,15H,5-6,8-9,11H2,1H3,(H2,22,24,25,26)
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n/an/a>1.00E+7n/an/an/an/a7.4n/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
Inhibitory activities of test compounds on 5 major isoforms of CYP P450 were evaluated by using pooled human liver microsome (HLM, purchased from BD ...


US Patent US9567341 (2017)


BindingDB Entry DOI: 10.7270/Q2DN473N
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM287598
PNG
(BDBM413606 | US9567341, Compound C-6)
Show SMILES FC(F)c1ccc(nc1)C(F)(F)CN1CCC(CC1)Nc1ncnc2[nH]ccc12
Show InChI InChI=1S/C19H20F4N6/c20-16(21)12-1-2-15(25-9-12)19(22,23)10-29-7-4-13(5-8-29)28-18-14-3-6-24-17(14)26-11-27-18/h1-3,6,9,11,13,16H,4-5,7-8,10H2,(H2,24,26,27,28)
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n/an/a>1.00E+7n/an/an/an/a7.4n/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
Inhibitory activities of test compounds on 5 major isoforms of CYP P450 were evaluated by using pooled human liver microsome (HLM, purchased from BD ...


US Patent US9567341 (2017)


BindingDB Entry DOI: 10.7270/Q2DN473N
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM287599
PNG
(BDBM413607 | US9567341, Compound C-7)
Show SMILES FCc1ccc(nc1)C(F)(F)CN1CCC(CC1)Nc1ncnc2[nH]ccc12
Show InChI InChI=1S/C19H21F3N6/c20-9-13-1-2-16(24-10-13)19(21,22)11-28-7-4-14(5-8-28)27-18-15-3-6-23-17(15)25-12-26-18/h1-3,6,10,12,14H,4-5,7-9,11H2,(H2,23,25,26,27)
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n/an/a>1.00E+7n/an/an/an/a7.4n/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
Inhibitory activities of test compounds on 5 major isoforms of CYP P450 were evaluated by using pooled human liver microsome (HLM, purchased from BD ...


US Patent US9567341 (2017)


BindingDB Entry DOI: 10.7270/Q2DN473N
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM287600
PNG
(US10420768, Compound C-11 | US9567341, Compound C-...)
Show SMILES FC(F)(F)Oc1ccc(nc1)C(F)(F)CN1CCC(CC1)Nc1ncnc2[nH]ccc12
Show InChI InChI=1S/C19H19F5N6O/c20-18(21,15-2-1-13(9-26-15)31-19(22,23)24)10-30-7-4-12(5-8-30)29-17-14-3-6-25-16(14)27-11-28-17/h1-3,6,9,11-12H,4-5,7-8,10H2,(H2,25,27,28,29)
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n/an/a>1.00E+7n/an/an/an/a7.4n/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
Inhibitory activities of test compounds on 5 major isoforms of CYP P450 were evaluated by using pooled human liver microsome (HLM, purchased from BD ...


US Patent US9567341 (2017)


BindingDB Entry DOI: 10.7270/Q2DN473N
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM287601
PNG
(US10420768, Compound C-12 | US9567341, Compound C-...)
Show SMILES FC(F)(CN1CCC(CC1)Nc1ncnc2[nH]ccc12)c1ccccn1
Show InChI InChI=1S/C18H20F2N6/c19-18(20,15-3-1-2-7-21-15)11-26-9-5-13(6-10-26)25-17-14-4-8-22-16(14)23-12-24-17/h1-4,7-8,12-13H,5-6,9-11H2,(H2,22,23,24,25)
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Rugen Holdings (Cayman) Limited

US Patent


Assay Description
Inhibitory activities of test compounds on 5 major isoforms of CYP P450 were evaluated by using pooled human liver microsome (HLM, purchased from BD ...


US Patent US9567341 (2017)


BindingDB Entry DOI: 10.7270/Q2DN473N
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM287602
PNG
(US10420768, Compound C-178 | US9567341, Compound C...)
Show SMILES FC(F)(F)c1ccc(cc1)C(F)(F)CN1CCC(CC1)Nc1ncnc2[nH]ccc12
Show InChI InChI=1S/C20H20F5N5/c21-19(22,13-1-3-14(4-2-13)20(23,24)25)11-30-9-6-15(7-10-30)29-18-16-5-8-26-17(16)27-12-28-18/h1-5,8,12,15H,6-7,9-11H2,(H2,26,27,28,29)
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Rugen Holdings (Cayman) Limited

US Patent


Assay Description
Inhibitory activities of test compounds on 5 major isoforms of CYP P450 were evaluated by using pooled human liver microsome (HLM, purchased from BD ...


US Patent US9567341 (2017)


BindingDB Entry DOI: 10.7270/Q2DN473N
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM287603
PNG
(BDBM393497 | BDBM413611 | US9567341, Compound C-17...)
Show SMILES FC(F)c1ccc(cc1)C(F)(F)CN1CCC(CC1)Nc1ncnc2[nH]ccc12
Show InChI InChI=1S/C20H21F4N5/c21-17(22)13-1-3-14(4-2-13)20(23,24)11-29-9-6-15(7-10-29)28-19-16-5-8-25-18(16)26-12-27-19/h1-5,8,12,15,17H,6-7,9-11H2,(H2,25,26,27,28)
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n/an/a>1.00E+7n/an/an/an/a7.4n/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
Inhibitory activities of test compounds on 5 major isoforms of CYP P450 were evaluated by using pooled human liver microsome (HLM, purchased from BD ...


US Patent US9567341 (2017)


BindingDB Entry DOI: 10.7270/Q2DN473N
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM287604
PNG
(US10420768, Compound C-175 | US9567341, Compound C...)
Show SMILES Fc1ccc(cc1)C(F)(F)CN1CCC(CC1)Nc1ncnc2[nH]ccc12
Show InChI InChI=1S/C19H20F3N5/c20-14-3-1-13(2-4-14)19(21,22)11-27-9-6-15(7-10-27)26-18-16-5-8-23-17(16)24-12-25-18/h1-5,8,12,15H,6-7,9-11H2,(H2,23,24,25,26)
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n/an/a>1.00E+7n/an/an/an/a7.4n/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
Inhibitory activities of test compounds on 5 major isoforms of CYP P450 were evaluated by using pooled human liver microsome (HLM, purchased from BD ...


US Patent US9567341 (2017)


BindingDB Entry DOI: 10.7270/Q2DN473N
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM287605
PNG
(US10420768, Compound C-176 | US9567341, Compound C...)
Show SMILES FC(F)(CN1CCC(CC1)Nc1ncnc2[nH]ccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H20ClF2N5/c20-14-3-1-13(2-4-14)19(21,22)11-27-9-6-15(7-10-27)26-18-16-5-8-23-17(16)24-12-25-18/h1-5,8,12,15H,6-7,9-11H2,(H2,23,24,25,26)
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n/an/a>1.00E+7n/an/an/an/a7.4n/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
Inhibitory activities of test compounds on 5 major isoforms of CYP P450 were evaluated by using pooled human liver microsome (HLM, purchased from BD ...


US Patent US9567341 (2017)


BindingDB Entry DOI: 10.7270/Q2DN473N
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM287606
PNG
(US10420768, Compound C-177 | US9567341, Compound C...)
Show SMILES Cc1ccc(cc1)C(F)(F)CN1CCC(CC1)Nc1ncnc2[nH]ccc12
Show InChI InChI=1S/C20H23F2N5/c1-14-2-4-15(5-3-14)20(21,22)12-27-10-7-16(8-11-27)26-19-17-6-9-23-18(17)24-13-25-19/h2-6,9,13,16H,7-8,10-12H2,1H3,(H2,23,24,25,26)
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n/an/a>1.00E+7n/an/an/an/a7.4n/a



Rugen Holdings (Cayman) Limited

US Patent


Assay Description
Inhibitory activities of test compounds on 5 major isoforms of CYP P450 were evaluated by using pooled human liver microsome (HLM, purchased from BD ...


US Patent US9567341 (2017)


BindingDB Entry DOI: 10.7270/Q2DN473N
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM50044140
PNG
(2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone | ...)
Show SMILES CNC1(CCCCC1=O)c1ccccc1Cl
Show InChI InChI=1S/C13H16ClNO/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14/h2-3,6-7,15H,4-5,8-9H2,1H3
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1.90E+3n/an/an/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Binding affinity to NMDA receptor (unknown origin)


Bioorg Med Chem 27: 1226-1231 (2019)


Article DOI: 10.1016/j.bmc.2019.02.010
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM50086368
PNG
(4-Benzyl-1-[2-(2H-[1,2,4]triazol-3-ylsulfanyl)-eth...)
Show SMILES C(CN1CCC(Cc2ccccc2)CC1)Sc1nnc[nH]1
Show InChI InChI=1S/C16H22N4S/c1-2-4-14(5-3-1)12-15-6-8-20(9-7-15)10-11-21-16-17-13-18-19-16/h1-5,13,15H,6-12H2,(H,17,18,19)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Antagonistic activity against NR1A/2A receptors in frog oocytes


Bioorg Med Chem Lett 10: 527-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00035-4
BindingDB Entry DOI: 10.7270/Q26Q1WG4
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM50086369
PNG
(2-(3-(4-benzylpiperidin-1-yl)propylthio)-5-methyl-...)
Show SMILES Cc1nnc(SCCCN2CCC(Cc3ccccc3)CC2)s1
Show InChI InChI=1S/C18H25N3S2/c1-15-19-20-18(23-15)22-13-5-10-21-11-8-17(9-12-21)14-16-6-3-2-4-7-16/h2-4,6-7,17H,5,8-14H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Antagonistic activity against NR1A/2A receptors in frog oocytes


Bioorg Med Chem Lett 10: 527-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00035-4
BindingDB Entry DOI: 10.7270/Q26Q1WG4
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM50086372
PNG
(5-[3-(4-Benzyl-piperidin-1-yl)-propylsulfanyl]-[1,...)
Show SMILES Nc1nnc(SCCCN2CCC(Cc3ccccc3)CC2)s1
Show InChI InChI=1S/C17H24N4S2/c18-16-19-20-17(23-16)22-12-4-9-21-10-7-15(8-11-21)13-14-5-2-1-3-6-14/h1-3,5-6,15H,4,7-13H2,(H2,18,19)
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n/an/a 7.30E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Antagonistic activity against NR1A/2A receptors in frog oocytes


Bioorg Med Chem Lett 10: 527-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00035-4
BindingDB Entry DOI: 10.7270/Q26Q1WG4
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM50086374
PNG
(2-[3-(4-Benzyl-piperidin-1-yl)-propylsulfanyl]-1H-...)
Show SMILES C(CSc1nc2ccccc2[nH]1)CN1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C22H27N3S/c1-2-7-18(8-3-1)17-19-11-14-25(15-12-19)13-6-16-26-22-23-20-9-4-5-10-21(20)24-22/h1-5,7-10,19H,6,11-17H2,(H,23,24)
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n/an/a 6.40E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Antagonistic activity against NR1A/2A receptors in frog oocytes


Bioorg Med Chem Lett 10: 527-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00035-4
BindingDB Entry DOI: 10.7270/Q26Q1WG4
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM50086375
PNG
(4-Benzyl-1-[2-(5-methyl-2H-[1,2,4]triazol-3-ylsulf...)
Show SMILES Cc1nnc(SCCN2CCC(Cc3ccccc3)CC2)[nH]1
Show InChI InChI=1S/C17H24N4S/c1-14-18-17(20-19-14)22-12-11-21-9-7-16(8-10-21)13-15-5-3-2-4-6-15/h2-6,16H,7-13H2,1H3,(H,18,19,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Antagonistic activity against NR1A/2A receptors in frog oocytes


Bioorg Med Chem Lett 10: 527-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00035-4
BindingDB Entry DOI: 10.7270/Q26Q1WG4
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM50086380
PNG
(2-[3-(4-Benzyl-piperidin-1-yl)-propylsulfanyl]-3H-...)
Show SMILES C(CSc1nc2ncccc2[nH]1)CN1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H26N4S/c1-2-6-17(7-3-1)16-18-9-13-25(14-10-18)12-5-15-26-21-23-19-8-4-11-22-20(19)24-21/h1-4,6-8,11,18H,5,9-10,12-16H2,(H,22,23,24)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Antagonistic activity against NR1A/2A receptors in frog oocytes


Bioorg Med Chem Lett 10: 527-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00035-4
BindingDB Entry DOI: 10.7270/Q26Q1WG4
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM50086378
PNG
(2-[2-(4-Benzyl-piperidin-1-yl)-ethylsulfanyl]-3H-i...)
Show SMILES C(CN1CCC(Cc2ccccc2)CC1)Sc1nc2ncccc2[nH]1
Show InChI InChI=1S/C20H24N4S/c1-2-5-16(6-3-1)15-17-8-11-24(12-9-17)13-14-25-20-22-18-7-4-10-21-19(18)23-20/h1-7,10,17H,8-9,11-15H2,(H,21,22,23)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Antagonistic activity against NR1A/2A receptors in frog oocytes


Bioorg Med Chem Lett 10: 527-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00035-4
BindingDB Entry DOI: 10.7270/Q26Q1WG4
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM50086379
PNG
(2-[2-(4-Benzyl-piperidin-1-yl)-ethylsulfanyl]-5-ni...)
Show SMILES [O-][N+](=O)c1ccc2nc(SCCN3CCC(Cc4ccccc4)CC3)[nH]c2c1
Show InChI InChI=1S/C21H24N4O2S/c26-25(27)18-6-7-19-20(15-18)23-21(22-19)28-13-12-24-10-8-17(9-11-24)14-16-4-2-1-3-5-16/h1-7,15,17H,8-14H2,(H,22,23)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Antagonistic activity against NR1A/2A receptors in frog oocytes


Bioorg Med Chem Lett 10: 527-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00035-4
BindingDB Entry DOI: 10.7270/Q26Q1WG4
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM50086373
PNG
(4-Benzyl-1-[2-(5-methyl-[1,3,4]thiadiazol-2-ylsulf...)
Show SMILES Cc1nnc(SCCN2CCC(Cc3ccccc3)CC2)s1
Show InChI InChI=1S/C17H23N3S2/c1-14-18-19-17(22-14)21-12-11-20-9-7-16(8-10-20)13-15-5-3-2-4-6-15/h2-6,16H,7-13H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Antagonistic activity against NR1A/2A receptors in frog oocytes


Bioorg Med Chem Lett 10: 527-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00035-4
BindingDB Entry DOI: 10.7270/Q26Q1WG4
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM50086381
PNG
(4-Benzyl-1-[3-(5-methyl-2H-[1,2,4]triazol-3-ylsulf...)
Show SMILES Cc1nnc(SCCCN2CCC(Cc3ccccc3)CC2)[nH]1
Show InChI InChI=1S/C18H26N4S/c1-15-19-18(21-20-15)23-13-5-10-22-11-8-17(9-12-22)14-16-6-3-2-4-7-16/h2-4,6-7,17H,5,8-14H2,1H3,(H,19,20,21)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Antagonistic activity against NR1A/2A receptors in frog oocytes


Bioorg Med Chem Lett 10: 527-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00035-4
BindingDB Entry DOI: 10.7270/Q26Q1WG4
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM50086382
PNG
(4-Benzyl-1-(2-phenylsulfanyl-ethyl)-piperidine | C...)
Show SMILES C(CN1CCC(Cc2ccccc2)CC1)Sc1ccccc1
Show InChI InChI=1S/C20H25NS/c1-3-7-18(8-4-1)17-19-11-13-21(14-12-19)15-16-22-20-9-5-2-6-10-20/h1-10,19H,11-17H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Antagonistic activity against NR1A/2A receptors in frog oocytes


Bioorg Med Chem Lett 10: 527-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00035-4
BindingDB Entry DOI: 10.7270/Q26Q1WG4
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM50086384
PNG
(5-[3-(4-Benzyl-piperidin-1-yl)-propylsulfanyl]-1H-...)
Show SMILES Nc1nnc(SCCCN2CCC(Cc3ccccc3)CC2)[nH]1
Show InChI InChI=1S/C17H25N5S/c18-16-19-17(21-20-16)23-12-4-9-22-10-7-15(8-11-22)13-14-5-2-1-3-6-14/h1-3,5-6,15H,4,7-13H2,(H3,18,19,20,21)
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n/an/a 7.70E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Antagonistic activity against NR1A/2A receptors in frog oocytes


Bioorg Med Chem Lett 10: 527-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00035-4
BindingDB Entry DOI: 10.7270/Q26Q1WG4
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM50086371
PNG
(2-[3-(4-Benzyl-piperidin-1-yl)-propylsulfanyl]-5-n...)
Show SMILES [O-][N+](=O)c1ccc2nc(SCCCN3CCC(Cc4ccccc4)CC3)[nH]c2c1
Show InChI InChI=1S/C22H26N4O2S/c27-26(28)19-7-8-20-21(16-19)24-22(23-20)29-14-4-11-25-12-9-18(10-13-25)15-17-5-2-1-3-6-17/h1-3,5-8,16,18H,4,9-15H2,(H,23,24)
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n/an/a 6.10E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Antagonistic activity against NR1A/2A receptors in frog oocytes


Bioorg Med Chem Lett 10: 527-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00035-4
BindingDB Entry DOI: 10.7270/Q26Q1WG4
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM50086370
PNG
(4-Benzyl-1-(3-phenylsulfanyl-propyl)-piperidine | ...)
Show SMILES C(CSc1ccccc1)CN1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H27NS/c1-3-8-19(9-4-1)18-20-12-15-22(16-13-20)14-7-17-23-21-10-5-2-6-11-21/h1-6,8-11,20H,7,12-18H2
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n/an/a 8.50E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Antagonistic activity against NR1A/2A receptors in frog oocytes


Bioorg Med Chem Lett 10: 527-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00035-4
BindingDB Entry DOI: 10.7270/Q26Q1WG4
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM50078480
PNG
(4-[4-(4-Benzyl-piperidin-1-yl)-but-1-ynyl]-phenol ...)
Show SMILES Oc1ccc(cc1)C#CCCN1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C22H25NO/c24-22-11-9-19(10-12-22)6-4-5-15-23-16-13-21(14-17-23)18-20-7-2-1-3-8-20/h1-3,7-12,21,24H,5,13-18H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Antagonistic activity against NR1A/2A receptors in frog oocytes


Bioorg Med Chem Lett 10: 527-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00035-4
BindingDB Entry DOI: 10.7270/Q26Q1WG4
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM50086386
PNG
(5-[2-(4-Benzyl-piperidin-1-yl)-ethylsulfanyl]-[1,3...)
Show SMILES Nc1nnc(SCCN2CCC(Cc3ccccc3)CC2)s1
Show InChI InChI=1S/C16H22N4S2/c17-15-18-19-16(22-15)21-11-10-20-8-6-14(7-9-20)12-13-4-2-1-3-5-13/h1-5,14H,6-12H2,(H2,17,18)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Antagonistic activity against NR1A/2A receptors in frog oocytes


Bioorg Med Chem Lett 10: 527-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00035-4
BindingDB Entry DOI: 10.7270/Q26Q1WG4
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM50086377
PNG
(4-Benzyl-1-[2-(1H-imidazol-2-ylsulfanyl)-ethyl]-pi...)
Show SMILES C(CN1CCC(Cc2ccccc2)CC1)Sc1ncc[nH]1
Show InChI InChI=1S/C17H23N3S/c1-2-4-15(5-3-1)14-16-6-10-20(11-7-16)12-13-21-17-18-8-9-19-17/h1-5,8-9,16H,6-7,10-14H2,(H,18,19)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Antagonistic activity against NR1A/2A receptors in frog oocytes


Bioorg Med Chem Lett 10: 527-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00035-4
BindingDB Entry DOI: 10.7270/Q26Q1WG4
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM50086387
PNG
(5-[2-(4-Benzyl-piperidin-1-yl)-ethylsulfanyl]-1H-[...)
Show SMILES Nc1nnc(SCCN2CCC(Cc3ccccc3)CC2)[nH]1
Show InChI InChI=1S/C16H23N5S/c17-15-18-16(20-19-15)22-11-10-21-8-6-14(7-9-21)12-13-4-2-1-3-5-13/h1-5,14H,6-12H2,(H3,17,18,19,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Antagonistic activity against NR1A/2A receptors in frog oocytes


Bioorg Med Chem Lett 10: 527-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00035-4
BindingDB Entry DOI: 10.7270/Q26Q1WG4
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM50086383
PNG
(4-[2-(4-Benzyl-piperidin-1-yl)-ethylsulfanyl]-phen...)
Show SMILES Oc1ccc(SCCN2CCC(Cc3ccccc3)CC2)cc1
Show InChI InChI=1S/C20H25NOS/c22-19-6-8-20(9-7-19)23-15-14-21-12-10-18(11-13-21)16-17-4-2-1-3-5-17/h1-9,18,22H,10-16H2
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n/an/a 3.50E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Antagonistic activity against NR1A/2A receptors in frog oocytes


Bioorg Med Chem Lett 10: 527-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00035-4
BindingDB Entry DOI: 10.7270/Q26Q1WG4
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM50086376
PNG
(2-[2-(4-Benzyl-piperidin-1-yl)-ethylsulfanyl]-1H-b...)
Show SMILES C(CN1CCC(Cc2ccccc2)CC1)Sc1nc2ccccc2[nH]1
Show InChI InChI=1S/C21H25N3S/c1-2-6-17(7-3-1)16-18-10-12-24(13-11-18)14-15-25-21-22-19-8-4-5-9-20(19)23-21/h1-9,18H,10-16H2,(H,22,23)
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n/an/a 7.50E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Antagonistic activity against NR1A/2A receptors in frog oocytes


Bioorg Med Chem Lett 10: 527-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00035-4
BindingDB Entry DOI: 10.7270/Q26Q1WG4
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM50086385
PNG
(4-Benzyl-1-[3-(2H-[1,2,4]triazol-3-ylsulfanyl)-pro...)
Show SMILES C(CSc1nnc[nH]1)CN1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C17H24N4S/c1-2-5-15(6-3-1)13-16-7-10-21(11-8-16)9-4-12-22-17-18-14-19-20-17/h1-3,5-6,14,16H,4,7-13H2,(H,18,19,20)
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n/an/a 5.10E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Antagonistic activity against NR1A/2A receptors in frog oocytes


Bioorg Med Chem Lett 10: 527-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00035-4
BindingDB Entry DOI: 10.7270/Q26Q1WG4
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM50086388
PNG
(4-Benzyl-1-[3-(1H-imidazol-2-ylsulfanyl)-propyl]-p...)
Show SMILES C(CSc1ncc[nH]1)CN1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C18H25N3S/c1-2-5-16(6-3-1)15-17-7-12-21(13-8-17)11-4-14-22-18-19-9-10-20-18/h1-3,5-6,9-10,17H,4,7-8,11-15H2,(H,19,20)
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n/an/a 7.70E+4n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by ChEMBL


Assay Description
Antagonistic activity against NR1A/2A receptors in frog oocytes


Bioorg Med Chem Lett 10: 527-9 (2000)


Article DOI: 10.1016/s0960-894x(00)00035-4
BindingDB Entry DOI: 10.7270/Q26Q1WG4
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM50124909
PNG
(CHEMBL159744 | N-(3,5-Dimethyl-benzyl)-4-trifluoro...)
Show SMILES Cc1cc(C)cc(CN=C(N)c2ccc(OC(F)(F)F)cc2)c1
Show InChI InChI=1S/C17H17F3N2O/c1-11-7-12(2)9-13(8-11)10-22-16(21)14-3-5-15(6-4-14)23-17(18,19)20/h3-9H,10H2,1-2H3,(H2,21,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of the response to NMDA glutamate/glycine receptor NR2A subtype was determined using FLIPR assay


Bioorg Med Chem Lett 13: 697-700 (2003)


Article DOI: 10.1016/s0960-894x(02)01061-2
BindingDB Entry DOI: 10.7270/Q2FX78TP
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM50124914
PNG
(CHEMBL161180 | N-(3,5-Dichloro-benzyl)-4-trifluoro...)
Show SMILES NC(=NCc1cc(Cl)cc(Cl)c1)c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C15H11Cl2F3N2O/c16-11-5-9(6-12(17)7-11)8-22-14(21)10-1-3-13(4-2-10)23-15(18,19)20/h1-7H,8H2,(H2,21,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of the response to NMDA glutamate/glycine receptor NR2A subtype was determined using FLIPR assay


Bioorg Med Chem Lett 13: 697-700 (2003)


Article DOI: 10.1016/s0960-894x(02)01061-2
BindingDB Entry DOI: 10.7270/Q2FX78TP
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM50124918
PNG
(3,4-Dichloro-N-(2-trifluoromethoxy-benzyl)-benzami...)
Show SMILES NC(=NCc1ccccc1OC(F)(F)F)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H11Cl2F3N2O/c16-11-6-5-9(7-12(11)17)14(21)22-8-10-3-1-2-4-13(10)23-15(18,19)20/h1-7H,8H2,(H2,21,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of the response to NMDA glutamate/glycine receptor NR2A subtype was determined using FLIPR assay


Bioorg Med Chem Lett 13: 697-700 (2003)


Article DOI: 10.1016/s0960-894x(02)01061-2
BindingDB Entry DOI: 10.7270/Q2FX78TP
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM50124907
PNG
(4-trifluoromethoxy-N-(2-trifluoromethyl-benzyl)-be...)
Show SMILES NC(=NCc1ccccc1C(F)(F)F)c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C16H12F6N2O/c17-15(18,19)13-4-2-1-3-11(13)9-24-14(23)10-5-7-12(8-6-10)25-16(20,21)22/h1-8H,9H2,(H2,23,24)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of the response to NMDA glutamate/glycine receptor NR2A subtype was determined using FLIPR assay


Bioorg Med Chem Lett 13: 697-700 (2003)


Article DOI: 10.1016/s0960-894x(02)01061-2
BindingDB Entry DOI: 10.7270/Q2FX78TP
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM50124919
PNG
(3,4-Dichloro-N-(3-chloro-benzyl)-benzamidine | CHE...)
Show SMILES NC(=NCc1cccc(Cl)c1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H11Cl3N2/c15-11-3-1-2-9(6-11)8-19-14(18)10-4-5-12(16)13(17)7-10/h1-7H,8H2,(H2,18,19)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of the response to NMDA glutamate/glycine receptor NR2A subtype was determined using FLIPR assay


Bioorg Med Chem Lett 13: 697-700 (2003)


Article DOI: 10.1016/s0960-894x(02)01061-2
BindingDB Entry DOI: 10.7270/Q2FX78TP
More data for this
Ligand-Target Pair
NMDA receptor subtype 2A protein (NR2A)


(Homo sapiens (Human))
BDBM50070788
PNG
(CHEMBL48029 | N-(4-(benzyloxy)phenethyl)pyridin-4-...)
Show SMILES C(Cc1ccc(OCc2ccccc2)cc1)Nc1ccncc1
Show InChI InChI=1S/C20H20N2O/c1-2-4-18(5-3-1)16-23-20-8-6-17(7-9-20)10-15-22-19-11-13-21-14-12-19/h1-9,11-14H,10,15-16H2,(H,21,22)
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n/an/a>2.00E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Activity at human NR2A expressed in Ltk- cells by calcium flux assay


J Med Chem 50: 807-19 (2007)


Article DOI: 10.1021/jm060983w
BindingDB Entry DOI: 10.7270/Q2FX7944
More data for this
Ligand-Target Pair
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