BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 82 hits Enz. Inhib. hit(s) with Target = 'Neuraminidase B'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuraminidase B


(Influenza B virus)
BDBM4926
PNG
((2R,3R,4S)-4-amino-3-acetamido-2-(propylcarbamoyl)...)
Show SMILES CCCNC(=O)[C@@H]1OC(=C[C@H](N)[C@H]1NC(C)=O)C(O)=O
Show InChI InChI=1S/C12H19N3O5/c1-3-4-14-11(17)10-9(15-6(2)16)7(13)5-8(20-10)12(18)19/h5,7,9-10H,3-4,13H2,1-2H3,(H,14,17)(H,15,16)(H,18,19)/t7-,9+,10+/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 5.00E+4n/an/an/an/a6.537



Glaxo Wellcome Research and Development Limited



Assay Description
A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...


J Med Chem 41: 787-97 (1998)


Article DOI: 10.1021/jm970374b
BindingDB Entry DOI: 10.7270/Q2RF5S7G
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus (B/Memphis/3/89))
BDBM4707
PNG
(3-(2,2-diaminoimino)-4-methylcarboxamidobenzoate |...)
Show SMILES CC(=O)Nc1ccc(cc1N=C(N)N)C(O)=O
Show InChI InChI=1S/C10H12N4O3/c1-5(15)13-7-3-2-6(9(16)17)4-8(7)14-10(11)12/h2-4H,1H3,(H,13,15)(H,16,17)(H4,11,12,14)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.00E+4n/an/an/an/a6.537



University of Alabama at Birmingham



Assay Description
A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...


Bioorg Med Chem Lett 9: 1901-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00318-2
BindingDB Entry DOI: 10.7270/Q2T72FN4
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus (B/Victoria/70))
BDBM5025
PNG
(Oseltamivir | ethyl (3R,4R,5S)-5-amino-4-acetamido...)
Show SMILES CCOC(=O)C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](N)C1
Show InChI InChI=1S/C16H28N2O4/c1-5-12(6-2)22-14-9-11(16(20)21-7-3)8-13(17)15(14)18-10(4)19/h9,12-15H,5-8,17H2,1-4H3,(H,18,19)/t13-,14+,15+/m0/s1
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
Purchase

DrugBank
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 5n/an/an/an/a6.537



BioCryst Pharmaceuticals, Inc.



Assay Description
A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...


J Med Chem 44: 4379-92 (2001)


Article DOI: 10.1021/jm010277p
BindingDB Entry DOI: 10.7270/Q2GX48RZ
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus (B/Victoria/70))
BDBM4934
PNG
((2R,3R,4S)-4-carbamimidamido-3-acetamido-2-[(1R,2R...)
Show SMILES CC(=O)N[C@@H]1[C@H](C=C(O[C@H]1[C@H](O)[C@H](O)CO)C(O)=O)N=C(N)N
Show InChI InChI=1S/C12H20N4O7/c1-4(18)15-8-5(16-12(13)14)2-7(11(21)22)23-10(8)9(20)6(19)3-17/h2,5-6,8-10,17,19-20H,3H2,1H3,(H,15,18)(H,21,22)(H4,13,14,16)/t5-,6+,8+,9+,10+/m0/s1
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
Purchase

DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 17n/an/an/an/a6.537



BioCryst Pharmaceuticals, Inc.



Assay Description
A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...


J Med Chem 44: 4379-92 (2001)


Article DOI: 10.1021/jm010277p
BindingDB Entry DOI: 10.7270/Q2GX48RZ
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus (B/Victoria/70))
BDBM5024
PNG
((-)-(1S,2S,3R,4R)-3-[(1S)-1-(Acetylamino)-2-ethylb...)
Show SMILES CCC(CC)[C@H](NC(C)=O)[C@@H]1[C@H](O)[C@H](C[C@H]1N=C(N)N)C(O)=O
Show InChI InChI=1S/C15H28N4O4/c1-4-8(5-2)12(18-7(3)20)11-10(19-15(16)17)6-9(13(11)21)14(22)23/h8-13,21H,4-6H2,1-3H3,(H,18,20)(H,22,23)(H4,16,17,19)/t9-,10+,11+,12-,13+/m0/s1
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
Purchase

MMDB
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 5n/an/an/an/a6.537



BioCryst Pharmaceuticals, Inc.



Assay Description
A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...


J Med Chem 44: 4379-92 (2001)


Article DOI: 10.1021/jm010277p
BindingDB Entry DOI: 10.7270/Q2GX48RZ
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus (B/Victoria/70))
BDBM5023
PNG
((-)-(1R,3R,4R)-3-[(1S)-1-(Acetylamino)-2-ethylbuty...)
Show SMILES CCC(CC)[C@H](NC(C)=O)[C@@H]1C[C@H](C[C@H]1N=C(N)N)C(O)=O
Show InChI InChI=1S/C15H28N4O3/c1-4-9(5-2)13(18-8(3)20)11-6-10(14(21)22)7-12(11)19-15(16)17/h9-13H,4-7H2,1-3H3,(H,18,20)(H,21,22)(H4,16,17,19)/t10-,11-,12-,13+/m1/s1
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2n/an/an/an/a6.537



BioCryst Pharmaceuticals, Inc.



Assay Description
A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...


J Med Chem 44: 4379-92 (2001)


Article DOI: 10.1021/jm010277p
BindingDB Entry DOI: 10.7270/Q2GX48RZ
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus (B/Victoria/70))
BDBM5022
PNG
((1R*,3R*,4R*)-3-[(1R*)-1-(Acetylamino)pentyl]-4-{[...)
Show SMILES CCCC[C@@H](NC(C)=O)[C@@H]1C[C@H](C[C@H]1N=C(N)N)C(O)=O
Show InChI InChI=1S/C14H26N4O3/c1-3-4-5-11(17-8(2)19)10-6-9(13(20)21)7-12(10)18-14(15)16/h9-12H,3-7H2,1-2H3,(H,17,19)(H,20,21)(H4,15,16,18)/t9-,10+,11-,12-/m1/s1
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.00E+5n/an/an/an/a6.537



BioCryst Pharmaceuticals, Inc.



Assay Description
A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...


J Med Chem 44: 4379-92 (2001)


Article DOI: 10.1021/jm010277p
BindingDB Entry DOI: 10.7270/Q2GX48RZ
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus (B/Victoria/70))
BDBM5021
PNG
((1R,3R,4R)-3-carbamimidamido-4-[(1S)-1-acetamidope...)
Show SMILES CCCC[C@H](NC(C)=O)[C@@H]1C[C@H](C[C@H]1N=C(N)N)C(O)=O
Show InChI InChI=1S/C14H26N4O3/c1-3-4-5-11(17-8(2)19)10-6-9(13(20)21)7-12(10)18-14(15)16/h9-12H,3-7H2,1-2H3,(H,17,19)(H,20,21)(H4,15,16,18)/t9-,10+,11+,12-/m1/s1
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 412n/an/an/an/a6.537



BioCryst Pharmaceuticals, Inc.



Assay Description
A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...


J Med Chem 44: 4379-92 (2001)


Article DOI: 10.1021/jm010277p
BindingDB Entry DOI: 10.7270/Q2GX48RZ
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus (B/Victoria/70))
BDBM5020
PNG
((1S,3R,4R)-3-carbamimidamido-4-[(1S)-1-acetamidope...)
Show SMILES CCCC[C@H](NC(C)=O)[C@@H]1C[C@@H](C[C@H]1N=C(N)N)C(O)=O
Show InChI InChI=1S/C14H26N4O3/c1-3-4-5-11(17-8(2)19)10-6-9(13(20)21)7-12(10)18-14(15)16/h9-12H,3-7H2,1-2H3,(H,17,19)(H,20,21)(H4,15,16,18)/t9-,10-,11-,12+/m0/s1
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.29E+3n/an/an/an/a6.537



BioCryst Pharmaceuticals, Inc.



Assay Description
A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...


J Med Chem 44: 4379-92 (2001)


Article DOI: 10.1021/jm010277p
BindingDB Entry DOI: 10.7270/Q2GX48RZ
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus (B/Victoria/70))
BDBM5019
PNG
((3R*,4R*)-3-[(1S*)-1-(Acetylamino)pentyl]-4-{[amin...)
Show SMILES CCCC[C@H](NC(C)=O)[C@@H]1CC(C[C@H]1N=C(N)N)C(O)=O
Show InChI InChI=1S/C14H26N4O3/c1-3-4-5-11(17-8(2)19)10-6-9(13(20)21)7-12(10)18-14(15)16/h9-12H,3-7H2,1-2H3,(H,17,19)(H,20,21)(H4,15,16,18)/t9?,10-,11-,12+/m0/s1
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 43n/an/an/an/a6.537



BioCryst Pharmaceuticals, Inc.



Assay Description
A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...


J Med Chem 44: 4379-92 (2001)


Article DOI: 10.1021/jm010277p
BindingDB Entry DOI: 10.7270/Q2GX48RZ
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus (B/Victoria/70))
BDBM5018
PNG
((3R*,4R*)-3-[1-(Acetylamino)pentyl]-4-{[amino(imin...)
Show SMILES CCCCC(NC(C)=O)[C@@H]1CC(C[C@H]1N=C(N)N)C(O)=O
Show InChI InChI=1S/C14H26N4O3/c1-3-4-5-11(17-8(2)19)10-6-9(13(20)21)7-12(10)18-14(15)16/h9-12H,3-7H2,1-2H3,(H,17,19)(H,20,21)(H4,15,16,18)/t9?,10-,11?,12+/m0/s1
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 893n/an/an/an/a6.537



BioCryst Pharmaceuticals, Inc.



Assay Description
A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...


J Med Chem 44: 4379-92 (2001)


Article DOI: 10.1021/jm010277p
BindingDB Entry DOI: 10.7270/Q2GX48RZ
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus (B/Victoria/70))
BDBM5017
PNG
((1R,3R,4S)-3-(Acetylamino-methyl)-4-guanidino-cycl...)
Show SMILES CC(=O)NC[C@H]1C[C@H](C[C@@H]1N=C(N)N)C(O)=O
Show InChI InChI=1S/C10H18N4O3/c1-5(15)13-4-7-2-6(9(16)17)3-8(7)14-10(11)12/h6-8H,2-4H2,1H3,(H,13,15)(H,16,17)(H4,11,12,14)/t6-,7-,8+/m1/s1
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.67E+4n/an/an/an/a6.537



BioCryst Pharmaceuticals, Inc.



Assay Description
A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...


J Med Chem 44: 4379-92 (2001)


Article DOI: 10.1021/jm010277p
BindingDB Entry DOI: 10.7270/Q2GX48RZ
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus)
BDBM4934
PNG
((2R,3R,4S)-4-carbamimidamido-3-acetamido-2-[(1R,2R...)
Show SMILES CC(=O)N[C@@H]1[C@H](C=C(O[C@H]1[C@H](O)[C@H](O)CO)C(O)=O)N=C(N)N
Show InChI InChI=1S/C12H20N4O7/c1-4(18)15-8-5(16-12(13)14)2-7(11(21)22)23-10(8)9(20)6(19)3-17/h2,5-6,8-10,17,19-20H,3H2,1H3,(H,15,18)(H,21,22)(H4,13,14,16)/t5-,6+,8+,9+,10+/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

MMDB
PDB
Article
PubMed
n/an/a 4n/an/an/an/a6.537



Glaxo Wellcome Research and Development Limited



Assay Description
A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...


J Med Chem 41: 787-97 (1998)


Article DOI: 10.1021/jm970374b
BindingDB Entry DOI: 10.7270/Q2RF5S7G
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Neuraminidase B


(Influenza B virus)
BDBM4929
PNG
((2R,3R,4S)-4-amino-2-(dipropylcarbamoyl)-3-acetami...)
Show SMILES CCCN(CCC)C(=O)[C@@H]1OC(=C[C@H](N)[C@H]1NC(C)=O)C(O)=O
Show InChI InChI=1S/C15H25N3O5/c1-4-6-18(7-5-2)14(20)13-12(17-9(3)19)10(16)8-11(23-13)15(21)22/h8,10,12-13H,4-7,16H2,1-3H3,(H,17,19)(H,21,22)/t10-,12+,13+/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.00E+3n/an/an/an/a6.537



Glaxo Wellcome Research and Development Limited



Assay Description
A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...


J Med Chem 41: 787-97 (1998)


Article DOI: 10.1021/jm970374b
BindingDB Entry DOI: 10.7270/Q2RF5S7G
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus)
BDBM4933
PNG
((2R,3R,4S)-4-carbamimidamido-3-acetamido-2-[methyl...)
Show SMILES CCCN(C)C(=O)[C@@H]1OC(=C[C@H](N=C(N)N)[C@H]1NC(C)=O)C(O)=O
Show InChI InChI=1S/C14H23N5O5/c1-4-5-19(3)12(21)11-10(17-7(2)20)8(18-14(15)16)6-9(24-11)13(22)23/h6,8,10-11H,4-5H2,1-3H3,(H,17,20)(H,22,23)(H4,15,16,18)/t8-,10+,11+/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
MMDB
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 4.50E+3n/an/an/an/a6.537



Glaxo Wellcome Research and Development Limited



Assay Description
A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...


J Med Chem 41: 787-97 (1998)


Article DOI: 10.1021/jm970374b
BindingDB Entry DOI: 10.7270/Q2RF5S7G
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus)
BDBM4932
PNG
((2R,3R,4S)-4-carbamimidamido-2-(dimethylcarbamoyl)...)
Show SMILES CN(C)C(=O)[C@@H]1OC(=C[C@H](N=C(N)N)[C@H]1NC(C)=O)C(O)=O
Show InChI InChI=1S/C12H19N5O5/c1-5(18)15-8-6(16-12(13)14)4-7(11(20)21)22-9(8)10(19)17(2)3/h4,6,8-9H,1-3H3,(H,15,18)(H,20,21)(H4,13,14,16)/t6-,8+,9+/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.10E+4n/an/an/an/a6.537



Glaxo Wellcome Research and Development Limited



Assay Description
A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...


J Med Chem 41: 787-97 (1998)


Article DOI: 10.1021/jm970374b
BindingDB Entry DOI: 10.7270/Q2RF5S7G
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus)
BDBM4931
PNG
((2R,3R,4S)-4-carbamimidamido-3-acetamido-2-(propyl...)
Show SMILES CCCNC(=O)[C@@H]1OC(=C[C@H](N=C(N)N)[C@H]1NC(C)=O)C(O)=O
Show InChI InChI=1S/C13H21N5O5/c1-3-4-16-11(20)10-9(17-6(2)19)7(18-13(14)15)5-8(23-10)12(21)22/h5,7,9-10H,3-4H2,1-2H3,(H,16,20)(H,17,19)(H,21,22)(H4,14,15,18)/t7-,9+,10+/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 4.40E+4n/an/an/an/a6.537



Glaxo Wellcome Research and Development Limited



Assay Description
A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...


J Med Chem 41: 787-97 (1998)


Article DOI: 10.1021/jm970374b
BindingDB Entry DOI: 10.7270/Q2RF5S7G
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus)
BDBM4928
PNG
((2R,3R,4S)-4-amino-3-acetamido-2-[methyl(propyl)ca...)
Show SMILES CCCN(C)C(=O)[C@@H]1OC(=C[C@H](N)[C@H]1NC(C)=O)C(O)=O
Show InChI InChI=1S/C13H21N3O5/c1-4-5-16(3)12(18)11-10(15-7(2)17)8(14)6-9(21-11)13(19)20/h6,8,10-11H,4-5,14H2,1-3H3,(H,15,17)(H,19,20)/t8-,10+,11+/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.30E+4n/an/an/an/a6.537



Glaxo Wellcome Research and Development Limited



Assay Description
A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...


J Med Chem 41: 787-97 (1998)


Article DOI: 10.1021/jm970374b
BindingDB Entry DOI: 10.7270/Q2RF5S7G
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus)
BDBM4927
PNG
((2R,3R,4S)-4-amino-2-(dimethylcarbamoyl)-3-acetami...)
Show SMILES CN(C)C(=O)[C@@H]1OC(=C[C@H](N)[C@H]1NC(C)=O)C(O)=O
Show InChI InChI=1S/C11H17N3O5/c1-5(15)13-8-6(12)4-7(11(17)18)19-9(8)10(16)14(2)3/h4,6,8-9H,12H2,1-3H3,(H,13,15)(H,17,18)/t6-,8+,9+/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.10E+4n/an/an/an/a6.537



Glaxo Wellcome Research and Development Limited



Assay Description
A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...


J Med Chem 41: 787-97 (1998)


Article DOI: 10.1021/jm970374b
BindingDB Entry DOI: 10.7270/Q2RF5S7G
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus (B/Memphis/3/89))
BDBM5278
PNG
(3-carbamimidamido-4-(2-oxopyrrolidin-1-yl)benzoic ...)
Show SMILES NC(=N)Nc1cc(ccc1N1CCCC1=O)C(O)=O
Show InChI InChI=1S/C12H14N4O3/c13-12(14)15-8-6-7(11(18)19)3-4-9(8)16-5-1-2-10(16)17/h3-4,6H,1-2,5H2,(H,18,19)(H4,13,14,15)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.00E+6n/an/an/an/a6.537



University of Alabama at Birmingham



Assay Description
A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...


Bioorg Med Chem Lett 9: 1901-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00318-2
BindingDB Entry DOI: 10.7270/Q2T72FN4
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus (B/Memphis/3/93))
BDBM5200
PNG
((+/-)-(2R,4R,5R,1 S)-5-(1 -Acetylamino-3 -methylbu...)
Show SMILES CC(C)C[C@H](NC(C)=O)[C@@H]1N[C@H](C[C@H]1c1ccn[nH]1)C(O)=O
Show InChI InChI=1S/C15H24N4O3/c1-8(2)6-12(17-9(3)20)14-10(11-4-5-16-19-11)7-13(18-14)15(21)22/h4-5,8,10,12-14,18H,6-7H2,1-3H3,(H,16,19)(H,17,20)(H,21,22)/t10-,12-,13+,14+/m0/s1
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
57 -40.9n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
A fluorogenic assay was used to measure influenza virus neuraminidase activity. The substrate, 4-methylumbelliferyl-N-acetylneuraminic acid, is cleav...


J Med Chem 48: 3980-90 (2005)


Article DOI: 10.1021/jm049276y
BindingDB Entry DOI: 10.7270/Q2KP80B9
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus (B/Memphis/3/93))
BDBM5195
PNG
((+/-)-(2R,4R,5S,1 S)-5-(1 -Acetylamino-3 -methylbu...)
Show SMILES COC(=O)[C@@H]1C[C@@H](N[C@H]1[C@H](CC(C)C)NC(C)=O)C(O)=O
Show InChI InChI=1S/C14H24N2O5/c1-7(2)5-10(15-8(3)17)12-9(14(20)21-4)6-11(16-12)13(18)19/h7,9-12,16H,5-6H2,1-4H3,(H,15,17)(H,18,19)/t9-,10+,11-,12-/m1/s1
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
150 -38.6n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
A fluorogenic assay was used to measure influenza virus neuraminidase activity. The substrate, 4-methylumbelliferyl-N-acetylneuraminic acid, is cleav...


J Med Chem 48: 3980-90 (2005)


Article DOI: 10.1021/jm049276y
BindingDB Entry DOI: 10.7270/Q2KP80B9
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus (B/Memphis/3/93))
BDBM5198
PNG
((+/-)-(2R,4R,5R,1 S)-5-(1 -Acetylamino-3 -methyl-b...)
Show SMILES CC(C)C[C@H](NC(C)=O)[C@@H]1N[C@H](C[C@H]1c1nccs1)C(O)=O
Show InChI InChI=1S/C15H23N3O3S/c1-8(2)6-11(17-9(3)19)13-10(14-16-4-5-22-14)7-12(18-13)15(20)21/h4-5,8,10-13,18H,6-7H2,1-3H3,(H,17,19)(H,20,21)/t10-,11+,12-,13-/m1/s1
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
370 -36.3n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
A fluorogenic assay was used to measure influenza virus neuraminidase activity. The substrate, 4-methylumbelliferyl-N-acetylneuraminic acid, is cleav...


J Med Chem 48: 3980-90 (2005)


Article DOI: 10.1021/jm049276y
BindingDB Entry DOI: 10.7270/Q2KP80B9
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus (B/Memphis/3/93))
BDBM5197
PNG
((+/-)-(2R,4R,5R,1 S)-5-(1 -Acetylamino-3 -methyl-b...)
Show SMILES CC(C)C[C@H](NC(C)=O)[C@@H]1N[C@H](C[C@H]1c1cscn1)C(O)=O
Show InChI InChI=1S/C15H23N3O3S/c1-8(2)4-11(17-9(3)19)14-10(13-6-22-7-16-13)5-12(18-14)15(20)21/h6-8,10-12,14,18H,4-5H2,1-3H3,(H,17,19)(H,20,21)/t10-,11-,12+,14+/m0/s1
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
490 -35.7n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
A fluorogenic assay was used to measure influenza virus neuraminidase activity. The substrate, 4-methylumbelliferyl-N-acetylneuraminic acid, is cleav...


J Med Chem 48: 3980-90 (2005)


Article DOI: 10.1021/jm049276y
BindingDB Entry DOI: 10.7270/Q2KP80B9
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus (B/Memphis/3/93))
BDBM5196
PNG
((+/-)-(2R,4R,5R,1 S)-5-(1 -Acetylamino-3 -methyl-b...)
Show SMILES CC(C)C[C@H](NC(C)=O)[C@@H]1N[C@H](C[C@H]1c1cnc[nH]1)C(O)=O
Show InChI InChI=1S/C15H24N4O3/c1-8(2)4-11(18-9(3)20)14-10(13-6-16-7-17-13)5-12(19-14)15(21)22/h6-8,10-12,14,19H,4-5H2,1-3H3,(H,16,17)(H,18,20)(H,21,22)/t10-,11-,12+,14+/m0/s1
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
610 -35.1n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
A fluorogenic assay was used to measure influenza virus neuraminidase activity. The substrate, 4-methylumbelliferyl-N-acetylneuraminic acid, is cleav...


J Med Chem 48: 3980-90 (2005)


Article DOI: 10.1021/jm049276y
BindingDB Entry DOI: 10.7270/Q2KP80B9
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus (B/Memphis/3/93))
BDBM5199
PNG
((+/-)-(2R,4R,5R,1 S)-5-(1 -Acetylamino-3 -methylbu...)
Show SMILES CC(C)C[C@H](NC(C)=O)[C@@H]1N[C@H](C[C@H]1c1ncc[nH]1)C(O)=O
Show InChI InChI=1S/C15H24N4O3/c1-8(2)6-11(18-9(3)20)13-10(14-16-4-5-17-14)7-12(19-13)15(21)22/h4-5,8,10-13,19H,6-7H2,1-3H3,(H,16,17)(H,18,20)(H,21,22)/t10-,11+,12-,13-/m1/s1
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
830 -34.4n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
A fluorogenic assay was used to measure influenza virus neuraminidase activity. The substrate, 4-methylumbelliferyl-N-acetylneuraminic acid, is cleav...


J Med Chem 48: 3980-90 (2005)


Article DOI: 10.1021/jm049276y
BindingDB Entry DOI: 10.7270/Q2KP80B9
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus (B/Memphis/3/93))
BDBM5194
PNG
((+/-)-(2R,4R,5R,1 S)-5-(1 -Acetylamino-3 -methyl-b...)
Show SMILES CC(C)C[C@H](NC(C)=O)[C@@H]1N[C@H](C[C@H]1N)C(O)=O
Show InChI InChI=1S/C12H23N3O3/c1-6(2)4-9(14-7(3)16)11-8(13)5-10(15-11)12(17)18/h6,8-11,15H,4-5,13H2,1-3H3,(H,14,16)(H,17,18)/t8-,9+,10-,11-/m1/s1
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
1.56E+3 -32.8n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
A fluorogenic assay was used to measure influenza virus neuraminidase activity. The substrate, 4-methylumbelliferyl-N-acetylneuraminic acid, is cleav...


J Med Chem 48: 3980-90 (2005)


Article DOI: 10.1021/jm049276y
BindingDB Entry DOI: 10.7270/Q2KP80B9
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus (B/Memphis/3/93))
BDBM5192
PNG
((+/-)-(2R,4R,5R,1 S)-5-(1 -Acetylamino-3 -methyl-b...)
Show SMILES CCC(=O)[C@@H]1C[C@@H](N[C@H]1[C@H](CC(C)C)NC(C)=O)C(O)=O
Show InChI InChI=1S/C15H26N2O4/c1-5-13(19)10-7-12(15(20)21)17-14(10)11(6-8(2)3)16-9(4)18/h8,10-12,14,17H,5-7H2,1-4H3,(H,16,18)(H,20,21)/t10-,11-,12+,14+/m0/s1
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
6.67E+3 -29.2n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
A fluorogenic assay was used to measure influenza virus neuraminidase activity. The substrate, 4-methylumbelliferyl-N-acetylneuraminic acid, is cleav...


J Med Chem 48: 3980-90 (2005)


Article DOI: 10.1021/jm049276y
BindingDB Entry DOI: 10.7270/Q2KP80B9
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus (B/Memphis/3/93))
BDBM5190
PNG
((+/-)-(2R,4R,5R,1 S)-5-(1 -Acetylamino-3 -methyl-b...)
Show SMILES CCOC(=O)[C@@H]1C[C@@H](N[C@H]1[C@H](CC(C)C)NC(C)=O)C(O)=O
Show InChI InChI=1S/C15H26N2O5/c1-5-22-15(21)10-7-12(14(19)20)17-13(10)11(6-8(2)3)16-9(4)18/h8,10-13,17H,5-7H2,1-4H3,(H,16,18)(H,19,20)/t10-,11+,12-,13-/m1/s1
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.24E+4 -27.7n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
A fluorogenic assay was used to measure influenza virus neuraminidase activity. The substrate, 4-methylumbelliferyl-N-acetylneuraminic acid, is cleav...


J Med Chem 48: 3980-90 (2005)


Article DOI: 10.1021/jm049276y
BindingDB Entry DOI: 10.7270/Q2KP80B9
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus (B/Memphis/3/93))
BDBM5191
PNG
((+/-)-(2R,4R,5R,1 S)-5-(1 -Acetylamino-3 -methyl-b...)
Show SMILES COC[C@@H]1C[C@@H](N[C@H]1[C@H](CC(C)C)NC(C)=O)C(O)=O
Show InChI InChI=1S/C14H26N2O4/c1-8(2)5-11(15-9(3)17)13-10(7-20-4)6-12(16-13)14(18)19/h8,10-13,16H,5-7H2,1-4H3,(H,15,17)(H,18,19)/t10-,11-,12+,13+/m0/s1
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.51E+4 -27.2n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
A fluorogenic assay was used to measure influenza virus neuraminidase activity. The substrate, 4-methylumbelliferyl-N-acetylneuraminic acid, is cleav...


J Med Chem 48: 3980-90 (2005)


Article DOI: 10.1021/jm049276y
BindingDB Entry DOI: 10.7270/Q2KP80B9
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus (B/Memphis/3/93))
BDBM5193
PNG
((+/-)-(2R,4R,5R,1 S)-5-(1 -Acetylamino-3 -methyl-b...)
Show SMILES CNC(=O)[C@@H]1C[C@@H](N[C@H]1[C@H](CC(C)C)NC(C)=O)C(O)=O
Show InChI InChI=1S/C14H25N3O4/c1-7(2)5-10(16-8(3)18)12-9(13(19)15-4)6-11(17-12)14(20)21/h7,9-12,17H,5-6H2,1-4H3,(H,15,19)(H,16,18)(H,20,21)/t9-,10+,11-,12-/m1/s1
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
>4.00E+4>-24.8n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
A fluorogenic assay was used to measure influenza virus neuraminidase activity. The substrate, 4-methylumbelliferyl-N-acetylneuraminic acid, is cleav...


J Med Chem 48: 3980-90 (2005)


Article DOI: 10.1021/jm049276y
BindingDB Entry DOI: 10.7270/Q2KP80B9
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus (B/Memphis/3/93))
BDBM5202
PNG
((+/-)-(2R,4S,5R,1 S)-5-(1 -Acetylamino-3 -methyl-b...)
Show SMILES C\C=C/[C@@H]1C[C@@H](N[C@H]1[C@H](CC(C)C)NC(C)=O)C(O)=O
Show InChI InChI=1S/C15H26N2O3/c1-5-6-11-8-13(15(19)20)17-14(11)12(7-9(2)3)16-10(4)18/h5-6,9,11-14,17H,7-8H2,1-4H3,(H,16,18)(H,19,20)/b6-5-/t11-,12+,13-,14-/m1/s1
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
30n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
A fluorogenic assay was used to measure influenza virus neuraminidase activity. The substrate, 4-methylumbelliferyl-N-acetylneuraminic acid, is cleav...


J Med Chem 48: 3980-90 (2005)


Article DOI: 10.1021/jm049276y
BindingDB Entry DOI: 10.7270/Q2KP80B9
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus (B/Memphis/3/93))
BDBM5207
PNG
((+/-)-(2R,4S,5R,1 S)-5-(1 -Acetylamino-3 -methyl-b...)
Show SMILES CC(C)C[C@H](NC(C)=O)[C@@H]1N[C@H](C[C@H]1\C=C/Cl)C(O)=O
Show InChI InChI=1S/C14H23ClN2O3/c1-8(2)6-11(16-9(3)18)13-10(4-5-15)7-12(17-13)14(19)20/h4-5,8,10-13,17H,6-7H2,1-3H3,(H,16,18)(H,19,20)/b5-4-/t10-,11+,12-,13-/m1/s1
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
130n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
A fluorogenic assay was used to measure influenza virus neuraminidase activity. The substrate, 4-methylumbelliferyl-N-acetylneuraminic acid, is cleav...


J Med Chem 48: 3980-90 (2005)


Article DOI: 10.1021/jm049276y
BindingDB Entry DOI: 10.7270/Q2KP80B9
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus (B/Memphis/3/93))
BDBM5202
PNG
((+/-)-(2R,4S,5R,1 S)-5-(1 -Acetylamino-3 -methyl-b...)
Show SMILES C\C=C/[C@@H]1C[C@@H](N[C@H]1[C@H](CC(C)C)NC(C)=O)C(O)=O
Show InChI InChI=1S/C15H26N2O3/c1-5-6-11-8-13(15(19)20)17-14(11)12(7-9(2)3)16-10(4)18/h5-6,9,11-14,17H,7-8H2,1-4H3,(H,16,18)(H,19,20)/b6-5-/t11-,12+,13-,14-/m1/s1
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
220n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
A fluorogenic assay was used to measure influenza virus neuraminidase activity. The substrate, 4-methylumbelliferyl-N-acetylneuraminic acid, is cleav...


J Med Chem 48: 3980-90 (2005)


Article DOI: 10.1021/jm049276y
BindingDB Entry DOI: 10.7270/Q2KP80B9
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus (B/Memphis/3/93))
BDBM5201
PNG
((2R,4R,5R)-5-[(1S)-1-acetamido-3-methylbutyl]-4-(1...)
Show SMILES CC(C)C[C@H](NC(C)=O)[C@@H]1N[C@H](C[C@H]1c1ccon1)C(O)=O
Show InChI InChI=1S/C15H23N3O4/c1-8(2)6-12(16-9(3)19)14-10(11-4-5-22-18-11)7-13(17-14)15(20)21/h4-5,8,10,12-14,17H,6-7H2,1-3H3,(H,16,19)(H,20,21)/t10-,12-,13+,14+/m0/s1
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
240n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
A fluorogenic assay was used to measure influenza virus neuraminidase activity. The substrate, 4-methylumbelliferyl-N-acetylneuraminic acid, is cleav...


J Med Chem 48: 3980-90 (2005)


Article DOI: 10.1021/jm049276y
BindingDB Entry DOI: 10.7270/Q2KP80B9
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus (B/Memphis/3/93))
BDBM5205
PNG
((+/-)-(2R,4S,5R,1 S)-5-(1 -Acetylamino-3 -methyl-b...)
Show SMILES CC(C)C[C@H](NC(C)=O)[C@@H]1N[C@H](C[C@H]1C=C(C)C)C(O)=O
Show InChI InChI=1S/C16H28N2O3/c1-9(2)6-12-8-14(16(20)21)18-15(12)13(7-10(3)4)17-11(5)19/h6,10,12-15,18H,7-8H2,1-5H3,(H,17,19)(H,20,21)/t12-,13+,14-,15-/m1/s1
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
340n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
A fluorogenic assay was used to measure influenza virus neuraminidase activity. The substrate, 4-methylumbelliferyl-N-acetylneuraminic acid, is cleav...


J Med Chem 48: 3980-90 (2005)


Article DOI: 10.1021/jm049276y
BindingDB Entry DOI: 10.7270/Q2KP80B9
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus (B/Memphis/3/93))
BDBM5203
PNG
((+/-)-(2R,4S,5R,1 S)-5-(1 -Acetylamino-3 -methyl-b...)
Show SMILES CC(C)C[C@H](NC(C)=O)[C@@H]1N[C@H](C[C@H]1C=C)C(O)=O
Show InChI InChI=1S/C14H24N2O3/c1-5-10-7-12(14(18)19)16-13(10)11(6-8(2)3)15-9(4)17/h5,8,10-13,16H,1,6-7H2,2-4H3,(H,15,17)(H,18,19)/t10-,11+,12-,13-/m1/s1
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
470n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
A fluorogenic assay was used to measure influenza virus neuraminidase activity. The substrate, 4-methylumbelliferyl-N-acetylneuraminic acid, is cleav...


J Med Chem 48: 3980-90 (2005)


Article DOI: 10.1021/jm049276y
BindingDB Entry DOI: 10.7270/Q2KP80B9
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus (B/Memphis/3/93))
BDBM5206
PNG
((+/-)-(2R,4S,5R,1 S)-5-(1 -Acetylamino-3 -methyl-b...)
Show SMILES CC(C)C[C@H](NC(C)=O)[C@@H]1N[C@H](C[C@H]1C=C(F)F)C(O)=O
Show InChI InChI=1S/C14H22F2N2O3/c1-7(2)4-10(17-8(3)19)13-9(6-12(15)16)5-11(18-13)14(20)21/h6-7,9-11,13,18H,4-5H2,1-3H3,(H,17,19)(H,20,21)/t9-,10-,11+,13+/m0/s1
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
660n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
A fluorogenic assay was used to measure influenza virus neuraminidase activity. The substrate, 4-methylumbelliferyl-N-acetylneuraminic acid, is cleav...


J Med Chem 48: 3980-90 (2005)


Article DOI: 10.1021/jm049276y
BindingDB Entry DOI: 10.7270/Q2KP80B9
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus (B/Memphis/3/93))
BDBM5207
PNG
((+/-)-(2R,4S,5R,1 S)-5-(1 -Acetylamino-3 -methyl-b...)
Show SMILES CC(C)C[C@H](NC(C)=O)[C@@H]1N[C@H](C[C@H]1\C=C/Cl)C(O)=O
Show InChI InChI=1S/C14H23ClN2O3/c1-8(2)6-11(16-9(3)18)13-10(4-5-15)7-12(17-13)14(19)20/h4-5,8,10-13,17H,6-7H2,1-3H3,(H,16,18)(H,19,20)/b5-4-/t10-,11+,12-,13-/m1/s1
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
4.60E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
A fluorogenic assay was used to measure influenza virus neuraminidase activity. The substrate, 4-methylumbelliferyl-N-acetylneuraminic acid, is cleav...


J Med Chem 48: 3980-90 (2005)


Article DOI: 10.1021/jm049276y
BindingDB Entry DOI: 10.7270/Q2KP80B9
More data for this
Ligand-Target Pair
Neuraminidase B (NanB)


(Streptococcus pneumoniae)
BDBM4706
PNG
((2R,3R,4S)-3-acetamido-4-hydroxy-2-[(1R,2R)-1,2,3-...)
Show SMILES CC(=O)N[C@@H]1[C@@H](O)C=C(O[C@H]1[C@H](O)[C@H](O)CO)C(O)=O
Show InChI InChI=1S/C11H17NO8/c1-4(14)12-8-5(15)2-7(11(18)19)20-10(8)9(17)6(16)3-13/h2,5-6,8-10,13,15-17H,3H2,1H3,(H,12,14)(H,18,19)/t5-,6+,8+,9+,10+/m0/s1
PDB

GoogleScholar
AffyNet 
Purchase

CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Similars

PDB
Article
PubMed
3.30E+5n/an/an/an/an/an/an/an/a



UniversitÓ degli Studi di Siena



Assay Description
Briefly, the reaction mixtures containing the substrates and up to 100 nM sialidase were incubated at 37░C and stopped by the addition of 0.5 M Na2CO...


BMC Biochem 13: 19 (2012)


Article DOI: 10.1186/1471-2091-13-19
BindingDB Entry DOI: 10.7270/Q2959GDQ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Neuraminidase B


(Influenza B virus)
BDBM4935
PNG
((2R,3R,4S)-4-amino-2-[(2,5-dimethylpyrrolidin-1-yl...)
Show SMILES CC1CCC(C)N1C(=O)[C@@H]1OC(=C[C@H](N)[C@H]1NC(C)=O)C(O)=O
Show InChI InChI=1S/C15H23N3O5/c1-7-4-5-8(2)18(7)14(20)13-12(17-9(3)19)10(16)6-11(23-13)15(21)22/h6-8,10,12-13H,4-5,16H2,1-3H3,(H,17,19)(H,21,22)/t7?,8?,10-,12+,13+/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.80E+3n/an/an/an/an/an/a



Glaxo Wellcome Research and Development Limited



Assay Description
A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...


J Med Chem 41: 787-97 (1998)


Article DOI: 10.1021/jm970374b
BindingDB Entry DOI: 10.7270/Q2RF5S7G
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus)
BDBM4978
PNG
((2R,3R,4S)-4-amino-2-{[(2R,5S)-2,5-diethylpyrrolid...)
Show SMILES CC[C@H]1CC[C@@H](CC)N1C(=O)[C@@H]1OC(=C[C@H](N)[C@H]1NC(C)=O)C(O)=O
Show InChI InChI=1S/C17H27N3O5/c1-4-10-6-7-11(5-2)20(10)16(22)15-14(19-9(3)21)12(18)8-13(25-15)17(23)24/h8,10-12,14-15H,4-7,18H2,1-3H3,(H,19,21)(H,23,24)/t10-,11+,12-,14+,15+/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.60E+4n/an/an/an/an/an/a



Glaxo Wellcome Research and Development Limited



Assay Description
A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...


J Med Chem 41: 787-97 (1998)


Article DOI: 10.1021/jm970374b
BindingDB Entry DOI: 10.7270/Q2RF5S7G
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus)
BDBM4937
PNG
((2R,3R,4S)-4-amino-2-(diethylcarbamoyl)-3-acetamid...)
Show SMILES CCN(CC)C(=O)[C@@H]1OC(=C[C@H](N)[C@H]1NC(C)=O)C(O)=O
Show InChI InChI=1S/C13H21N3O5/c1-4-16(5-2)12(18)11-10(15-7(3)17)8(14)6-9(21-11)13(19)20/h6,8,10-11H,4-5,14H2,1-3H3,(H,15,17)(H,19,20)/t8-,10+,11+/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
MMDB
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 360n/an/an/an/an/an/a



Glaxo Wellcome Research and Development Limited



Assay Description
A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...


J Med Chem 41: 787-97 (1998)


Article DOI: 10.1021/jm970374b
BindingDB Entry DOI: 10.7270/Q2RF5S7G
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus)
BDBM4938
PNG
((2R,3R,4S)-4-amino-2-[bis(prop-2-en-1-yl)carbamoyl...)
Show SMILES CC(=O)N[C@@H]1[C@@H](N)C=C(O[C@H]1C(=O)N(CC=C)CC=C)C(O)=O
Show InChI InChI=1S/C15H21N3O5/c1-4-6-18(7-5-2)14(20)13-12(17-9(3)19)10(16)8-11(23-13)15(21)22/h4-5,8,10,12-13H,1-2,6-7,16H2,3H3,(H,17,19)(H,21,22)/t10-,12+,13+/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 8.40E+3n/an/an/an/an/an/a



Glaxo Wellcome Research and Development Limited



Assay Description
A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...


J Med Chem 41: 787-97 (1998)


Article DOI: 10.1021/jm970374b
BindingDB Entry DOI: 10.7270/Q2RF5S7G
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus)
BDBM4939
PNG
((2R,3R,4S)-4-amino-2-(cyclohexylcarbamoyl)-3-aceta...)
Show SMILES CC(=O)N[C@@H]1[C@@H](N)C=C(O[C@H]1C(=O)NC1CCCCC1)C(O)=O
Show InChI InChI=1S/C15H23N3O5/c1-8(19)17-12-10(16)7-11(15(21)22)23-13(12)14(20)18-9-5-3-2-4-6-9/h7,9-10,12-13H,2-6,16H2,1H3,(H,17,19)(H,18,20)(H,21,22)/t10-,12+,13+/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>4.50E+5n/an/an/an/an/an/a



Glaxo Wellcome Research and Development Limited



Assay Description
A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...


J Med Chem 41: 787-97 (1998)


Article DOI: 10.1021/jm970374b
BindingDB Entry DOI: 10.7270/Q2RF5S7G
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus)
BDBM4940
PNG
((2R,3R,4S)-4-carbamimidamido-2-(dipropylcarbamoyl)...)
Show SMILES CCCN(CCC)C(=O)[C@@H]1OC(=C[C@H](N=C(N)N)[C@H]1NC(C)=O)C(O)=O
Show InChI InChI=1S/C16H27N5O5/c1-4-6-21(7-5-2)14(23)13-12(19-9(3)22)10(20-16(17)18)8-11(26-13)15(24)25/h8,10,12-13H,4-7H2,1-3H3,(H,19,22)(H,24,25)(H4,17,18,20)/t10-,12+,13+/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 540n/an/an/an/an/an/a



Glaxo Wellcome Research and Development Limited



Assay Description
A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...


J Med Chem 41: 787-97 (1998)


Article DOI: 10.1021/jm970374b
BindingDB Entry DOI: 10.7270/Q2RF5S7G
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus)
BDBM4942
PNG
((2R,3R,4S)-4-carbamimidamido-2-(diethylcarbamoyl)-...)
Show SMILES CCN(CC)C(=O)[C@@H]1OC(=C[C@H](N=C(N)N)[C@H]1NC(C)=O)C(O)=O
Show InChI InChI=1S/C14H23N5O5/c1-4-19(5-2)12(21)11-10(17-7(3)20)8(18-14(15)16)6-9(24-11)13(22)23/h6,8,10-11H,4-5H2,1-3H3,(H,17,20)(H,22,23)(H4,15,16,18)/t8-,10+,11+/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 490n/an/an/an/an/an/a



Glaxo Wellcome Research and Development Limited



Assay Description
A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...


J Med Chem 41: 787-97 (1998)


Article DOI: 10.1021/jm970374b
BindingDB Entry DOI: 10.7270/Q2RF5S7G
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus)
BDBM4941
PNG
((2R,3R,4S)-4-amino-3-acetamido-2-[ethyl(propyl)car...)
Show SMILES CCCN(CC)C(=O)[C@@H]1OC(=C[C@H](N)[C@H]1NC(C)=O)C(O)=O
Show InChI InChI=1S/C14H23N3O5/c1-4-6-17(5-2)13(19)12-11(16-8(3)18)9(15)7-10(22-12)14(20)21/h7,9,11-12H,4-6,15H2,1-3H3,(H,16,18)(H,20,21)/t9-,11+,12+/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 410n/an/an/an/an/an/a



Glaxo Wellcome Research and Development Limited



Assay Description
A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...


J Med Chem 41: 787-97 (1998)


Article DOI: 10.1021/jm970374b
BindingDB Entry DOI: 10.7270/Q2RF5S7G
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus)
BDBM4943
PNG
((2R,3R,4S)-4-amino-2-[butyl(propyl)carbamoyl]-3-ac...)
Show SMILES CCCCN(CCC)C(=O)[C@@H]1OC(=C[C@H](N)[C@H]1NC(C)=O)C(O)=O
Show InChI InChI=1S/C16H27N3O5/c1-4-6-8-19(7-5-2)15(21)14-13(18-10(3)20)11(17)9-12(24-14)16(22)23/h9,11,13-14H,4-8,17H2,1-3H3,(H,18,20)(H,22,23)/t11-,13+,14+/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 950n/an/an/an/an/an/a



Glaxo Wellcome Research and Development Limited



Assay Description
A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...


J Med Chem 41: 787-97 (1998)


Article DOI: 10.1021/jm970374b
BindingDB Entry DOI: 10.7270/Q2RF5S7G
More data for this
Ligand-Target Pair
Neuraminidase B


(Influenza B virus)
BDBM4944
PNG
((2R,3R,4S)-4-amino-2-[benzyl(propyl)carbamoyl]-3-a...)
Show SMILES CCCN(Cc1ccccc1)C(=O)[C@@H]1OC(=C[C@H](N)[C@H]1NC(C)=O)C(O)=O
Show InChI InChI=1S/C19H25N3O5/c1-3-9-22(11-13-7-5-4-6-8-13)18(24)17-16(21-12(2)23)14(20)10-15(27-17)19(25)26/h4-8,10,14,16-17H,3,9,11,20H2,1-2H3,(H,21,23)(H,25,26)/t14-,16+,17+/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.80E+5n/an/an/an/an/an/a



Glaxo Wellcome Research and Development Limited



Assay Description
A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...


J Med Chem 41: 787-97 (1998)


Article DOI: 10.1021/jm970374b
BindingDB Entry DOI: 10.7270/Q2RF5S7G
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 82 total )  |  Next  |  Last  >>
Jump to: