BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 909 hits Enz. Inhib. hit(s) with Target = 'Neutral endopeptidase (NEP)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neprilysin


(Homo sapiens (Human))
BDBM50197513
PNG
((S)-2-((1-((2-(hydroxymethyl)-2,3-dihydro-1H-inden...)
Show SMILES COCC[C@H](CC1(CCCC1)C(=O)NC1(CO)Cc2ccccc2C1)C(O)=O
Show InChI InChI=1S/C22H31NO5/c1-28-11-8-18(19(25)26)12-21(9-4-5-10-21)20(27)23-22(15-24)13-16-6-2-3-7-17(16)14-22/h2-3,6-7,18,24H,4-5,8-15H2,1H3,(H,23,27)(H,25,26)/t18-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 3.70n/an/an/an/a7.0n/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human kidney NEP at pH 7


Bioorg Med Chem 15: 142-59 (2006)


Article DOI: 10.1016/j.bmc.2006.10.002
BindingDB Entry DOI: 10.7270/Q2ZS2W4J
More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM50197507
PNG
((S)-4-methoxy-2-{1-[(1R,2S)-2-(4-methoxy-phenyl)-c...)
Show SMILES COCC[C@H](CC1(CCCC1)C(=O)N[C@@H]1C[C@H]1c1ccc(OC)cc1)C(O)=O
Show InChI InChI=1S/C22H31NO5/c1-27-12-9-16(20(24)25)14-22(10-3-4-11-22)21(26)23-19-13-18(19)15-5-7-17(28-2)8-6-15/h5-8,16,18-19H,3-4,9-14H2,1-2H3,(H,23,26)(H,24,25)/t16-,18+,19-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.10n/an/an/an/a7.0n/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human kidney NEP at pH 7


Bioorg Med Chem 15: 142-59 (2006)


Article DOI: 10.1016/j.bmc.2006.10.002
BindingDB Entry DOI: 10.7270/Q2ZS2W4J
More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM50190746
PNG
((R)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...)
Show SMILES CCC[C@H](CC1(CCCC1)C(=O)Nc1nnc(CC)s1)C(O)=O
Show InChI InChI=1S/C16H25N3O3S/c1-3-7-11(13(20)21)10-16(8-5-6-9-16)14(22)17-15-19-18-12(4-2)23-15/h11H,3-10H2,1-2H3,(H,20,21)(H,17,19,22)/t11-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 18.9n/an/an/an/a7.0n/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human kidney NEP at pH 7


Bioorg Med Chem 15: 142-59 (2006)


Article DOI: 10.1016/j.bmc.2006.10.002
BindingDB Entry DOI: 10.7270/Q2ZS2W4J
More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM50197519
PNG
((S)-2-{1-[3-(4-fluoro-phenyl)-propylcarbamoyl]-cyc...)
Show SMILES COCC[C@H](CC1(CCCC1)C(=O)NCCCc1ccc(F)cc1)C(O)=O
Show InChI InChI=1S/C21H30FNO4/c1-27-14-10-17(19(24)25)15-21(11-2-3-12-21)20(26)23-13-4-5-16-6-8-18(22)9-7-16/h6-9,17H,2-5,10-15H2,1H3,(H,23,26)(H,24,25)/t17-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.60n/an/an/an/a7.0n/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human kidney NEP at pH 7


Bioorg Med Chem 15: 142-59 (2006)


Article DOI: 10.1016/j.bmc.2006.10.002
BindingDB Entry DOI: 10.7270/Q2ZS2W4J
More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM50197517
PNG
((S)-2-{1-[3-(4-chloro-phenyl)-propylcarbamoyl]-cyc...)
Show SMILES COCC[C@H](CC1(CCCC1)C(=O)NCCCc1ccc(Cl)cc1)C(O)=O
Show InChI InChI=1S/C21H30ClNO4/c1-27-14-10-17(19(24)25)15-21(11-2-3-12-21)20(26)23-13-4-5-16-6-8-18(22)9-7-16/h6-9,17H,2-5,10-15H2,1H3,(H,23,26)(H,24,25)/t17-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.30n/an/an/an/a7.0n/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human kidney NEP at pH 7


Bioorg Med Chem 15: 142-59 (2006)


Article DOI: 10.1016/j.bmc.2006.10.002
BindingDB Entry DOI: 10.7270/Q2ZS2W4J
More data for this
Ligand-Target Pair
Neutral endopeptidase (NEP)


(Homo sapiens (Human))
BDBM153112
PNG
(US8993631, 14-1 | US9006249, Example 1-1 | US96038...)
Show SMILES C[C@H](C[C@@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)c1cccc(c1)C(O)=O)C(O)=O
Show InChI InChI=1S/C26H25NO5/c1-17(25(29)30)14-23(27-24(28)21-8-5-9-22(16-21)26(31)32)15-18-10-12-20(13-11-18)19-6-3-2-4-7-19/h2-13,16-17,23H,14-15H2,1H3,(H,27,28)(H,29,30)(H,31,32)/t17-,23+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 283n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...


US Patent US8993631 (2015)


BindingDB Entry DOI: 10.7270/Q20C4THK
More data for this
Ligand-Target Pair
Neutral endopeptidase (NEP)


(Homo sapiens (Human))
BDBM153113
PNG
(US8993631, 15-1 | US9006249, Example 2-1 | US96038...)
Show SMILES C[C@H](C[C@@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)CC(C)(C)C(O)=O)C(O)=O
Show InChI InChI=1S/C24H29NO5/c1-16(22(27)28)13-20(25-21(26)15-24(2,3)23(29)30)14-17-9-11-19(12-10-17)18-7-5-4-6-8-18/h4-12,16,20H,13-15H2,1-3H3,(H,25,26)(H,27,28)(H,29,30)/t16-,20+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 267n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...


US Patent US8993631 (2015)


BindingDB Entry DOI: 10.7270/Q20C4THK
More data for this
Ligand-Target Pair
Neutral endopeptidase (NEP)


(Homo sapiens (Human))
BDBM153107
PNG
(US8993631, 16-3 | US9006249, Example 3-6 | US96038...)
Show SMILES C[C@H](C[C@@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)CCCc1ccc2nc(C)sc2c1)C(O)=O
Show InChI InChI=1S/C30H32N2O3S/c1-20(30(34)35)17-26(18-23-11-14-25(15-12-23)24-8-4-3-5-9-24)32-29(33)10-6-7-22-13-16-27-28(19-22)36-21(2)31-27/h3-5,8-9,11-16,19-20,26H,6-7,10,17-18H2,1-2H3,(H,32,33)(H,34,35)/t20-,26+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 250n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...


US Patent US8993631 (2015)


BindingDB Entry DOI: 10.7270/Q20C4THK
More data for this
Ligand-Target Pair
Neutral endopeptidase (NEP)


(Homo sapiens (Human))
BDBM153108
PNG
(US8993631, 16-5 | US9006249, Example 3-32 | US9603...)
Show SMILES C[C@H](C[C@@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)c1cc(ncn1)C(O)=O)C(O)=O
Show InChI InChI=1S/C24H23N3O5/c1-15(23(29)30)11-19(27-22(28)20-13-21(24(31)32)26-14-25-20)12-16-7-9-18(10-8-16)17-5-3-2-4-6-17/h2-10,13-15,19H,11-12H2,1H3,(H,27,28)(H,29,30)(H,31,32)/t15-,19+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...


US Patent US8993631 (2015)


BindingDB Entry DOI: 10.7270/Q20C4THK
More data for this
Ligand-Target Pair
Neutral endopeptidase (NEP)


(Homo sapiens (Human))
BDBM153109
PNG
(US8993631, 16-8 | US9006249, Example 3-60)
Show SMILES C[C@H](C[C@@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)c1c[nH]c(n1)C(O)=O)C(O)=O
Show InChI InChI=1S/C23H23N3O5/c1-14(22(28)29)11-18(25-21(27)19-13-24-20(26-19)23(30)31)12-15-7-9-17(10-8-15)16-5-3-2-4-6-16/h2-10,13-14,18H,11-12H2,1H3,(H,24,26)(H,25,27)(H,28,29)(H,30,31)/t14-,18+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 7.30n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...


US Patent US8993631 (2015)


BindingDB Entry DOI: 10.7270/Q20C4THK
More data for this
Ligand-Target Pair
Neutral endopeptidase (NEP)


(Homo sapiens (Human))
BDBM153114
PNG
(US8993631, 17 | US9006249, Example 5-1 | US9603819...)
Show SMILES C[C@H](C[C@@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)c1cc(=O)cc(o1)C(O)=O)C(O)=O
Show InChI InChI=1S/C25H23NO7/c1-15(24(29)30)11-19(26-23(28)21-13-20(27)14-22(33-21)25(31)32)12-16-7-9-18(10-8-16)17-5-3-2-4-6-17/h2-10,13-15,19H,11-12H2,1H3,(H,26,28)(H,29,30)(H,31,32)/t15-,19+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 350n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...


US Patent US8993631 (2015)


BindingDB Entry DOI: 10.7270/Q20C4THK
More data for this
Ligand-Target Pair
Neutral endopeptidase (NEP)


(Homo sapiens (Human))
BDBM153115
PNG
(US8993631, 18-1 | US9006249, Example 6-1 | US96038...)
Show SMILES C[C@H](C[C@@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)N1CCC[C@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C24H28N2O5/c1-16(22(27)28)14-20(25-24(31)26-13-5-8-21(26)23(29)30)15-17-9-11-19(12-10-17)18-6-3-2-4-7-18/h2-4,6-7,9-12,16,20-21H,5,8,13-15H2,1H3,(H,25,31)(H,27,28)(H,29,30)/t16-,20+,21+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 450n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...


US Patent US8993631 (2015)


BindingDB Entry DOI: 10.7270/Q20C4THK
More data for this
Ligand-Target Pair
Neutral endopeptidase (NEP)


(Homo sapiens (Human))
BDBM153116
PNG
(US8993631, 19 | US9006249, Example 7-1 | US9603819...)
Show SMILES C[C@H](C[C@@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)NCC(O)=O)C(O)=O
Show InChI InChI=1S/C21H24N2O5/c1-14(20(26)27)11-18(23-21(28)22-13-19(24)25)12-15-7-9-17(10-8-15)16-5-3-2-4-6-16/h2-10,14,18H,11-13H2,1H3,(H,24,25)(H,26,27)(H2,22,23,28)/t14-,18+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 93n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...


US Patent US8993631 (2015)


BindingDB Entry DOI: 10.7270/Q20C4THK
More data for this
Ligand-Target Pair
Neutral endopeptidase (NEP)


(Homo sapiens (Human))
BDBM153117
PNG
(US8993631, 20 | US9006249, Example 9-1 | US9603819...)
Show SMILES C[C@H](C[C@@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)n1ccc(n1)C(O)=O)C(O)=O
Show InChI InChI=1S/C23H23N3O5/c1-15(21(27)28)13-19(24-23(31)26-12-11-20(25-26)22(29)30)14-16-7-9-18(10-8-16)17-5-3-2-4-6-17/h2-12,15,19H,13-14H2,1H3,(H,24,31)(H,27,28)(H,29,30)/t15-,19+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 142n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...


US Patent US8993631 (2015)


BindingDB Entry DOI: 10.7270/Q20C4THK
More data for this
Ligand-Target Pair
Neutral endopeptidase (NEP)


(Homo sapiens (Human))
BDBM153118
PNG
(US8993631, 23)
Show SMILES C[C@H](C[C@@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)c1nnn[nH]1)C(O)=O
Show InChI InChI=1S/C20H21N5O3/c1-13(20(27)28)11-17(21-19(26)18-22-24-25-23-18)12-14-7-9-16(10-8-14)15-5-3-2-4-6-15/h2-10,13,17H,11-12H2,1H3,(H,21,26)(H,27,28)(H,22,23,24,25)/t13-,17+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 14n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...


US Patent US8993631 (2015)


BindingDB Entry DOI: 10.7270/Q20C4THK
More data for this
Ligand-Target Pair
Neutral endopeptidase (NEP)


(Homo sapiens (Human))
BDBM153119
PNG
(BDBM153120 | US8993631, 29)
Show SMILES C[C@H](C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)c1cc(O)no1)C(O)=O
Show InChI InChI=1S/C22H21ClN2O5/c1-13(22(28)29)9-18(24-21(27)19-12-20(26)25-30-19)10-14-5-7-15(8-6-14)16-3-2-4-17(23)11-16/h2-8,11-13,18H,9-10H2,1H3,(H,24,27)(H,25,26)(H,28,29)/t13-,18+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.0400n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...


US Patent US8993631 (2015)


BindingDB Entry DOI: 10.7270/Q20C4THK
More data for this
Ligand-Target Pair
Neutral endopeptidase (NEP)


(Homo sapiens (Human))
BDBM153119
PNG
(BDBM153120 | US8993631, 29)
Show SMILES C[C@H](C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)c1cc(O)no1)C(O)=O
Show InChI InChI=1S/C22H21ClN2O5/c1-13(22(28)29)9-18(24-21(27)19-12-20(26)25-30-19)10-14-5-7-15(8-6-14)16-3-2-4-17(23)11-16/h2-8,11-13,18H,9-10H2,1H3,(H,24,27)(H,25,26)(H,28,29)/t13-,18+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.0300n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...


US Patent US8993631 (2015)


BindingDB Entry DOI: 10.7270/Q20C4THK
More data for this
Ligand-Target Pair
Neutral endopeptidase (NEP)


(Homo sapiens (Human))
BDBM153121
PNG
(US8993631, 29-2 | US9006249, Example 49-1)
Show SMILES C[C@@H](C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)c1cc(O)no1)C(O)=O
Show InChI InChI=1S/C22H21ClN2O5/c1-13(22(28)29)9-18(24-21(27)19-12-20(26)25-30-19)10-14-5-7-15(8-6-14)16-3-2-4-17(23)11-16/h2-8,11-13,18H,9-10H2,1H3,(H,24,27)(H,25,26)(H,28,29)/t13-,18-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.300n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...


US Patent US8993631 (2015)


BindingDB Entry DOI: 10.7270/Q20C4THK
More data for this
Ligand-Target Pair
Neutral endopeptidase (NEP)


(Homo sapiens (Human))
BDBM153122
PNG
(US8993631, 32-1)
Show SMILES C[C@H](N[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)C(=O)Nc1nnn[nH]1)C(O)=O
Show InChI InChI=1S/C19H19ClN6O3/c1-11(18(28)29)21-16(17(27)22-19-23-25-26-24-19)9-12-5-7-13(8-6-12)14-3-2-4-15(20)10-14/h2-8,10-11,16,21H,9H2,1H3,(H,28,29)(H2,22,23,24,25,26,27)/t11-,16-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.0900n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...


US Patent US8993631 (2015)


BindingDB Entry DOI: 10.7270/Q20C4THK
More data for this
Ligand-Target Pair
Neutral endopeptidase (NEP)


(Homo sapiens (Human))
BDBM153123
PNG
(US8993631, 32-2)
Show SMILES C[C@H](N[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1Cl)C(=O)Nc1nnn[nH]1)C(O)=O
Show InChI InChI=1S/C19H18Cl2N6O3/c1-10(18(29)30)22-16(17(28)23-19-24-26-27-25-19)8-11-2-4-12(5-3-11)14-9-13(20)6-7-15(14)21/h2-7,9-10,16,22H,8H2,1H3,(H,29,30)(H2,23,24,25,26,27,28)/t10-,16-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.300n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...


US Patent US8993631 (2015)


BindingDB Entry DOI: 10.7270/Q20C4THK
More data for this
Ligand-Target Pair
Neutral endopeptidase (NEP)


(Homo sapiens (Human))
BDBM153124
PNG
(US8993631, 32-3)
Show SMILES C[C@H](N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)Nc1nnn[nH]1)C(O)=O
Show InChI InChI=1S/C19H20N6O3/c1-12(18(27)28)20-16(17(26)21-19-22-24-25-23-19)11-13-7-9-15(10-8-13)14-5-3-2-4-6-14/h2-10,12,16,20H,11H2,1H3,(H,27,28)(H2,21,22,23,24,25,26)/t12-,16-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 11n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...


US Patent US8993631 (2015)


BindingDB Entry DOI: 10.7270/Q20C4THK
More data for this
Ligand-Target Pair
Neutral endopeptidase (NEP)


(Homo sapiens (Human))
BDBM138393
PNG
(US8877786, Example 3-7 | US8993631, 32-4)
Show SMILES C[C@H](N[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)C(=O)Nc1cc(O)no1)C(O)=O
Show InChI InChI=1S/C21H20ClN3O5/c1-12(21(28)29)23-17(20(27)24-19-11-18(26)25-30-19)9-13-5-7-14(8-6-13)15-3-2-4-16(22)10-15/h2-8,10-12,17,23H,9H2,1H3,(H,24,27)(H,25,26)(H,28,29)/t12-,17-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.40n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...


US Patent US8993631 (2015)


BindingDB Entry DOI: 10.7270/Q20C4THK
More data for this
Ligand-Target Pair
Neutral endopeptidase (NEP)


(Homo sapiens (Human))
BDBM153125
PNG
(US8993631, 32-5)
Show SMILES C[C@H](N[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)C(=O)Nc1nnnn1C)C(O)=O
Show InChI InChI=1S/C20H21ClN6O3/c1-12(19(29)30)22-17(18(28)23-20-24-25-26-27(20)2)10-13-6-8-14(9-7-13)15-4-3-5-16(21)11-15/h3-9,11-12,17,22H,10H2,1-2H3,(H,29,30)(H,23,24,26,28)/t12-,17-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 91n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...


US Patent US8993631 (2015)


BindingDB Entry DOI: 10.7270/Q20C4THK
More data for this
Ligand-Target Pair
Neutral endopeptidase (NEP)


(Homo sapiens (Human))
BDBM153126
PNG
(US8993631, 32-6)
Show SMILES OC(=O)[C@H](CCc1ccccc1)N[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)C(=O)Nc1nnn[nH]1
Show InChI InChI=1S/C26H25ClN6O3/c27-21-8-4-7-20(16-21)19-12-9-18(10-13-19)15-23(24(34)29-26-30-32-33-31-26)28-22(25(35)36)14-11-17-5-2-1-3-6-17/h1-10,12-13,16,22-23,28H,11,14-15H2,(H,35,36)(H2,29,30,31,32,33,34)/t22-,23-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.200n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...


US Patent US8993631 (2015)


BindingDB Entry DOI: 10.7270/Q20C4THK
More data for this
Ligand-Target Pair
Neutral endopeptidase (NEP)


(Homo sapiens (Human))
BDBM153127
PNG
(US8993631, 32-7)
Show SMILES CC[C@H](N[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)C(=O)Nc1nnn[nH]1)C(O)=O
Show InChI InChI=1S/C20H21ClN6O3/c1-2-16(19(29)30)22-17(18(28)23-20-24-26-27-25-20)10-12-6-8-13(9-7-12)14-4-3-5-15(21)11-14/h3-9,11,16-17,22H,2,10H2,1H3,(H,29,30)(H2,23,24,25,26,27,28)/t16-,17-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.200n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...


US Patent US8993631 (2015)


BindingDB Entry DOI: 10.7270/Q20C4THK
More data for this
Ligand-Target Pair
Neutral endopeptidase (NEP)


(Homo sapiens (Human))
BDBM153128
PNG
(US8993631, 36)
Show SMILES C[C@H](C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)CCC(O)=O)C(O)=O
Show InChI InChI=1S/C22H24ClNO5/c1-14(22(28)29)11-19(24-20(25)9-10-21(26)27)12-15-5-7-16(8-6-15)17-3-2-4-18(23)13-17/h2-8,13-14,19H,9-12H2,1H3,(H,24,25)(H,26,27)(H,28,29)/t14-,19+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.300n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...


US Patent US8993631 (2015)


BindingDB Entry DOI: 10.7270/Q20C4THK
More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM186570
PNG
(US9163040, 2)
Show SMILES OC(=O)C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)CCP(O)(O)=O
Show InChI InChI=1S/C19H20ClFNO6P/c20-14-5-6-17(21)16(10-14)13-3-1-12(2-4-13)9-15(11-19(24)25)22-18(23)7-8-29(26,27)28/h1-6,10,15H,7-9,11H2,(H,22,23)(H,24,25)(H2,26,27,28)/t15-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.110n/an/an/an/a7.425



NOVARTIS AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 pM) is pre-incubated wi...


US Patent US9163040 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TV2
More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM50197507
PNG
((S)-4-methoxy-2-{1-[(1R,2S)-2-(4-methoxy-phenyl)-c...)
Show SMILES COCC[C@H](CC1(CCCC1)C(=O)N[C@@H]1C[C@H]1c1ccc(OC)cc1)C(O)=O
Show InChI InChI=1S/C22H31NO5/c1-27-12-9-16(20(24)25)14-22(10-3-4-11-22)21(26)23-19-13-18(19)15-5-7-17(28-2)8-6-15/h5-8,16,18-19H,3-4,9-14H2,1-2H3,(H,23,26)(H,24,25)/t16-,18+,19-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 13.8n/an/an/an/a7.4n/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human kidney NEP at pH 7.4


Bioorg Med Chem 15: 142-59 (2006)


Article DOI: 10.1016/j.bmc.2006.10.002
BindingDB Entry DOI: 10.7270/Q2ZS2W4J
More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM50197519
PNG
((S)-2-{1-[3-(4-fluoro-phenyl)-propylcarbamoyl]-cyc...)
Show SMILES COCC[C@H](CC1(CCCC1)C(=O)NCCCc1ccc(F)cc1)C(O)=O
Show InChI InChI=1S/C21H30FNO4/c1-27-14-10-17(19(24)25)15-21(11-2-3-12-21)20(26)23-13-4-5-16-6-8-18(22)9-7-16/h6-9,17H,2-5,10-15H2,1H3,(H,23,26)(H,24,25)/t17-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 12.6n/an/an/an/a7.4n/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human kidney NEP at pH 7.4


Bioorg Med Chem 15: 142-59 (2006)


Article DOI: 10.1016/j.bmc.2006.10.002
BindingDB Entry DOI: 10.7270/Q2ZS2W4J
More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM50197517
PNG
((S)-2-{1-[3-(4-chloro-phenyl)-propylcarbamoyl]-cyc...)
Show SMILES COCC[C@H](CC1(CCCC1)C(=O)NCCCc1ccc(Cl)cc1)C(O)=O
Show InChI InChI=1S/C21H30ClNO4/c1-27-14-10-17(19(24)25)15-21(11-2-3-12-21)20(26)23-13-4-5-16-6-8-18(22)9-7-16/h6-9,17H,2-5,10-15H2,1H3,(H,23,26)(H,24,25)/t17-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 10.5n/an/an/an/a7.4n/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human kidney NEP at pH 7.4


Bioorg Med Chem 15: 142-59 (2006)


Article DOI: 10.1016/j.bmc.2006.10.002
BindingDB Entry DOI: 10.7270/Q2ZS2W4J
More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM50190746
PNG
((R)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...)
Show SMILES CCC[C@H](CC1(CCCC1)C(=O)Nc1nnc(CC)s1)C(O)=O
Show InChI InChI=1S/C16H25N3O3S/c1-3-7-11(13(20)21)10-16(8-5-6-9-16)14(22)17-15-19-18-12(4-2)23-15/h11H,3-10H2,1-2H3,(H,20,21)(H,17,19,22)/t11-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 31.8n/an/an/an/a7.4n/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human kidney NEP at pH 7.4


Bioorg Med Chem 15: 142-59 (2006)


Article DOI: 10.1016/j.bmc.2006.10.002
BindingDB Entry DOI: 10.7270/Q2ZS2W4J
More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM50197513
PNG
((S)-2-((1-((2-(hydroxymethyl)-2,3-dihydro-1H-inden...)
Show SMILES COCC[C@H](CC1(CCCC1)C(=O)NC1(CO)Cc2ccccc2C1)C(O)=O
Show InChI InChI=1S/C22H31NO5/c1-28-11-8-18(19(25)26)12-21(9-4-5-10-21)20(27)23-22(15-24)13-16-6-2-3-7-17(16)14-22/h2-3,6-7,18,24H,4-5,8-15H2,1H3,(H,23,27)(H,25,26)/t18-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 10n/an/an/an/a7.4n/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human kidney NEP at pH 7.4


Bioorg Med Chem 15: 142-59 (2006)


Article DOI: 10.1016/j.bmc.2006.10.002
BindingDB Entry DOI: 10.7270/Q2ZS2W4J
More data for this
Ligand-Target Pair
Neutral endopeptidase (NEP)


(Homo sapiens (Human))
BDBM7494
PNG
(US8822534, 5-36 | US8822534, Example 5-1 | US89936...)
Show SMILES OC(=O)CCC(=O)N[C@@H](CC(O)=O)Cc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C20H21NO5/c22-18(10-11-19(23)24)21-17(13-20(25)26)12-14-6-8-16(9-7-14)15-4-2-1-3-5-15/h1-9,17H,10-13H2,(H,21,22)(H,23,24)(H,25,26)/t17-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 42n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...


US Patent US8822534 (2014)


BindingDB Entry DOI: 10.7270/Q2513WW2
More data for this
Ligand-Target Pair
Neutral endopeptidase (NEP)


(Homo sapiens (Human))
BDBM130350
PNG
(US8822534, Example 3-25 | US8993631, 3-12)
Show SMILES CCCCOC(=O)CCC(=O)N[C@@H](CC(O)=O)Cc1ccc(cc1)-c1cccc(Cl)c1
Show InChI InChI=1S/C24H28ClNO5/c1-2-3-13-31-24(30)12-11-22(27)26-21(16-23(28)29)14-17-7-9-18(10-8-17)19-5-4-6-20(25)15-19/h4-10,15,21H,2-3,11-14,16H2,1H3,(H,26,27)(H,28,29)/t21-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 18n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...


US Patent US8822534 (2014)


BindingDB Entry DOI: 10.7270/Q2513WW2
More data for this
Ligand-Target Pair
Neutral endopeptidase (NEP)


(Homo sapiens (Human))
BDBM130351
PNG
(US8822534, Example 3-26 | US8993631, 3-13)
Show SMILES CCOC(=O)CCCC(=O)N[C@@H](CC(O)=O)Cc1ccc(cc1)-c1cccc(Cl)c1
Show InChI InChI=1S/C23H26ClNO5/c1-2-30-23(29)8-4-7-21(26)25-20(15-22(27)28)13-16-9-11-17(12-10-16)18-5-3-6-19(24)14-18/h3,5-6,9-12,14,20H,2,4,7-8,13,15H2,1H3,(H,25,26)(H,27,28)/t20-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 15n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...


US Patent US8822534 (2014)


BindingDB Entry DOI: 10.7270/Q2513WW2
More data for this
Ligand-Target Pair
Neutral endopeptidase (NEP)


(Homo sapiens (Human))
BDBM130352
PNG
(US8822534, Example 3-27)
Show SMILES OC(=O)CC(Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)CCC(=O)Oc1ccc2CCCc2c1
Show InChI InChI=1S/C29H28ClNO5/c30-24-6-2-5-22(16-24)21-9-7-19(8-10-21)15-25(18-28(33)34)31-27(32)13-14-29(35)36-26-12-11-20-3-1-4-23(20)17-26/h2,5-12,16-17,25H,1,3-4,13-15,18H2,(H,31,32)(H,33,34)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 15n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...


US Patent US8822534 (2014)


BindingDB Entry DOI: 10.7270/Q2513WW2
More data for this
Ligand-Target Pair
Neutral endopeptidase (NEP)


(Homo sapiens (Human))
BDBM7494
PNG
(US8822534, 5-36 | US8822534, Example 5-1 | US89936...)
Show SMILES OC(=O)CCC(=O)N[C@@H](CC(O)=O)Cc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C20H21NO5/c22-18(10-11-19(23)24)21-17(13-20(25)26)12-14-6-8-16(9-7-14)15-4-2-1-3-5-15/h1-9,17H,10-13H2,(H,21,22)(H,23,24)(H,25,26)/t17-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 38n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...


US Patent US8822534 (2014)


BindingDB Entry DOI: 10.7270/Q2513WW2
More data for this
Ligand-Target Pair
Neutral endopeptidase (NEP)


(Homo sapiens (Human))
BDBM130354
PNG
(US8822534, Example 5-4 | US8993631, 5-2)
Show SMILES OC(=O)CCC(=O)N[C@@H](CC(O)=O)Cc1ccc(cc1)-c1cccc(F)c1
Show InChI InChI=1S/C20H20FNO5/c21-16-3-1-2-15(11-16)14-6-4-13(5-7-14)10-17(12-20(26)27)22-18(23)8-9-19(24)25/h1-7,11,17H,8-10,12H2,(H,22,23)(H,24,25)(H,26,27)/t17-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 7n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...


US Patent US8822534 (2014)


BindingDB Entry DOI: 10.7270/Q2513WW2
More data for this
Ligand-Target Pair
Neutral endopeptidase (NEP)


(Homo sapiens (Human))
BDBM130355
PNG
(US8822534, Example 5-7 | US8993631, 5-3)
Show SMILES COc1ccccc1-c1ccc(C[C@H](CC(O)=O)NC(=O)CCC(O)=O)cc1
Show InChI InChI=1S/C21H23NO6/c1-28-18-5-3-2-4-17(18)15-8-6-14(7-9-15)12-16(13-21(26)27)22-19(23)10-11-20(24)25/h2-9,16H,10-13H2,1H3,(H,22,23)(H,24,25)(H,26,27)/t16-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...


US Patent US8822534 (2014)


BindingDB Entry DOI: 10.7270/Q2513WW2
More data for this
Ligand-Target Pair
Neutral endopeptidase (NEP)


(Homo sapiens (Human))
BDBM130356
PNG
(US8822534, Example 5-11 | US8993631, 5-4)
Show SMILES OC(=O)C[C@@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)c1cnc(O)nc1
Show InChI InChI=1S/C21H19N3O4/c25-19(26)11-18(24-20(27)17-12-22-21(28)23-13-17)10-14-6-8-16(9-7-14)15-4-2-1-3-5-15/h1-9,12-13,18H,10-11H2,(H,24,27)(H,25,26)(H,22,23,28)/t18-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...


US Patent US8822534 (2014)


BindingDB Entry DOI: 10.7270/Q2513WW2
More data for this
Ligand-Target Pair
Neutral endopeptidase (NEP)


(Homo sapiens (Human))
BDBM130357
PNG
(US8822534, Example 5-12 | US8993631, 5-5)
Show SMILES OC(=O)C[C@@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)c1cc(ncn1)C(O)=O
Show InChI InChI=1S/C22H19N3O5/c26-20(27)11-17(25-21(28)18-12-19(22(29)30)24-13-23-18)10-14-6-8-16(9-7-14)15-4-2-1-3-5-15/h1-9,12-13,17H,10-11H2,(H,25,28)(H,26,27)(H,29,30)/t17-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 67n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...


US Patent US8822534 (2014)


BindingDB Entry DOI: 10.7270/Q2513WW2
More data for this
Ligand-Target Pair
Neutral endopeptidase (NEP)


(Homo sapiens (Human))
BDBM130358
PNG
(US8822534, Example 5-37 | US8993631, 5-7)
Show SMILES COc1ccc(F)cc1-c1ccc(C[C@H](CC(O)=O)NC(=O)CCC(O)=O)cc1
Show InChI InChI=1S/C21H22FNO6/c1-29-18-7-6-15(22)11-17(18)14-4-2-13(3-5-14)10-16(12-21(27)28)23-19(24)8-9-20(25)26/h2-7,11,16H,8-10,12H2,1H3,(H,23,24)(H,25,26)(H,27,28)/t16-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.30n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...


US Patent US8822534 (2014)


BindingDB Entry DOI: 10.7270/Q2513WW2
More data for this
Ligand-Target Pair
Neutral endopeptidase (NEP)


(Homo sapiens (Human))
BDBM130359
PNG
(US8822534, Example 5-39 | US8993631, 5-8)
Show SMILES COc1ccc(Cl)cc1-c1ccc(C[C@H](CC(O)=O)NC(=O)CCC(O)=O)cc1
Show InChI InChI=1S/C21H22ClNO6/c1-29-18-7-6-15(22)11-17(18)14-4-2-13(3-5-14)10-16(12-21(27)28)23-19(24)8-9-20(25)26/h2-7,11,16H,8-10,12H2,1H3,(H,23,24)(H,25,26)(H,27,28)/t16-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.700n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...


US Patent US8822534 (2014)


BindingDB Entry DOI: 10.7270/Q2513WW2
More data for this
Ligand-Target Pair
Neutral endopeptidase (NEP)


(Homo sapiens (Human))
BDBM130360
PNG
(US8822534, Example 5-46 | US8993631, 5-9)
Show SMILES OC(=O)C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)c1n[nH]c(=O)o1
Show InChI InChI=1S/C19H16ClN3O5/c20-14-3-1-2-13(9-14)12-6-4-11(5-7-12)8-15(10-16(24)25)21-17(26)18-22-23-19(27)28-18/h1-7,9,15H,8,10H2,(H,21,26)(H,23,27)(H,24,25)/t15-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.5n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...


US Patent US8822534 (2014)


BindingDB Entry DOI: 10.7270/Q2513WW2
More data for this
Ligand-Target Pair
Neutral endopeptidase (NEP)


(Homo sapiens (Human))
BDBM130361
PNG
(US8822534, Example 5-47 | US8993631, 5-10)
Show SMILES CCc1ncc(o1)C(=O)N[C@@H](CC(O)=O)Cc1ccc(cc1)-c1cccc(Cl)c1
Show InChI InChI=1S/C22H21ClN2O4/c1-2-20-24-13-19(29-20)22(28)25-18(12-21(26)27)10-14-6-8-15(9-7-14)16-4-3-5-17(23)11-16/h3-9,11,13,18H,2,10,12H2,1H3,(H,25,28)(H,26,27)/t18-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.70n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...


US Patent US8822534 (2014)


BindingDB Entry DOI: 10.7270/Q2513WW2
More data for this
Ligand-Target Pair
Neutral endopeptidase (NEP)


(Homo sapiens (Human))
BDBM130362
PNG
(US8822534, Example 5-55 | US8993631, 5-11)
Show SMILES COc1ccc(F)cc1-c1ccc(C[C@H](CC(O)=O)NC(=O)c2cc(O)no2)cc1
Show InChI InChI=1S/C21H19FN2O6/c1-29-17-7-6-14(22)9-16(17)13-4-2-12(3-5-13)8-15(10-20(26)27)23-21(28)18-11-19(25)24-30-18/h2-7,9,11,15H,8,10H2,1H3,(H,23,28)(H,24,25)(H,26,27)/t15-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.700n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...


US Patent US8822534 (2014)


BindingDB Entry DOI: 10.7270/Q2513WW2
More data for this
Ligand-Target Pair
Neutral endopeptidase (NEP)


(Homo sapiens (Human))
BDBM130363
PNG
(US8822534, Example 6-1 | US8993631, 6-1)
Show SMILES OC(=O)CCNC(=O)[C@@H](CC(O)=O)Cc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C20H21NO5/c22-18(23)10-11-21-20(26)17(13-19(24)25)12-14-6-8-16(9-7-14)15-4-2-1-3-5-15/h1-9,17H,10-13H2,(H,21,26)(H,22,23)(H,24,25)/t17-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 75n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...


US Patent US8822534 (2014)


BindingDB Entry DOI: 10.7270/Q2513WW2
More data for this
Ligand-Target Pair
Neutral endopeptidase (NEP)


(Homo sapiens (Human))
BDBM130364
PNG
(US8822534, Example 9-1 | US8993631, 8-1)
Show SMILES OC(=O)C[C@@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)c1nnn[nH]1
Show InChI InChI=1S/C18H17N5O3/c24-16(25)11-15(19-18(26)17-20-22-23-21-17)10-12-6-8-14(9-7-12)13-4-2-1-3-5-13/h1-9,15H,10-11H2,(H,19,26)(H,24,25)(H,20,21,22,23)/t15-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 56n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...


US Patent US8822534 (2014)


BindingDB Entry DOI: 10.7270/Q2513WW2
More data for this
Ligand-Target Pair
Neutral endopeptidase (NEP)


(Homo sapiens (Human))
BDBM130365
PNG
(US8822534, Example 11-1 | US8822534, Example 12-1 ...)
Show SMILES OC(=O)CCC(=O)N[C@@H](CC(O)=O)Cc1ccc(cc1)-c1cccc(Cl)c1
Show InChI InChI=1S/C20H20ClNO5/c21-16-3-1-2-15(11-16)14-6-4-13(5-7-14)10-17(12-20(26)27)22-18(23)8-9-19(24)25/h1-7,11,17H,8-10,12H2,(H,22,23)(H,24,25)(H,26,27)/t17-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.10n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...


US Patent US8822534 (2014)


BindingDB Entry DOI: 10.7270/Q2513WW2
More data for this
Ligand-Target Pair
Neutral endopeptidase (NEP)


(Homo sapiens (Human))
BDBM130366
PNG
(US8822534, Example 11-11 | US8993631, 9-6)
Show SMILES OC(=O)C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)C(F)(F)C(F)(F)C(O)=O
Show InChI InChI=1S/C20H16ClF4NO5/c21-14-3-1-2-13(9-14)12-6-4-11(5-7-12)8-15(10-16(27)28)26-17(29)19(22,23)20(24,25)18(30)31/h1-7,9,15H,8,10H2,(H,26,29)(H,27,28)(H,30,31)/t15-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.5n/an/an/an/a7.425



Novartis AG

US Patent


Assay Description
Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...


US Patent US8822534 (2014)


BindingDB Entry DOI: 10.7270/Q2513WW2
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 909 total )  |  Next  |  Last  >>
Jump to: