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Found 3243 hits Enz. Inhib. hit(s) with Target = 'Nicotinamide phosphoribosyltransferase'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50438936
PNG
(CHEMBL2420629 | GNE-617)
Show SMILES Fc1cc(F)cc(c1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)cc1
Show InChI InChI=1S/C21H15F2N3O3S/c22-16-9-17(23)11-19(10-16)30(28,29)18-4-1-14(2-5-18)12-25-21(27)15-3-6-20-24-7-8-26(20)13-15/h1-11,13H,12H2,(H,25,27)
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n/an/a 5n/an/an/an/a7.525



Genentech, Inc. 1 DNA Way, South San Francisco, California 94080 (USA).



Assay Description
The reaction was carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well plates. NAMPT protein was added to 1 B...


Chembiochem 15: 1121-30 (2014)


Article DOI: 10.1002/cbic.201402023
BindingDB Entry DOI: 10.7270/Q2X065QR
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM112625
PNG
(GNE-643)
Show SMILES Fc1cc(F)cc(c1)S(=O)(=O)c1ccc(CNC(=O)c2ccn3ccnc3c2)cc1
Show InChI InChI=1S/C21H15F2N3O3S/c22-16-10-17(23)12-19(11-16)30(28,29)18-3-1-14(2-4-18)13-25-21(27)15-5-7-26-8-6-24-20(26)9-15/h1-12H,13H2,(H,25,27)
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n/an/a 10n/an/an/an/a7.525



Genentech, Inc. 1 DNA Way, South San Francisco, California 94080 (USA).



Assay Description
The reaction was carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well plates. NAMPT protein was added to 1 B...


Chembiochem 15: 1121-30 (2014)


Article DOI: 10.1002/cbic.201402023
BindingDB Entry DOI: 10.7270/Q2X065QR
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM112626
PNG
(GNE-200)
Show SMILES Fc1cc(F)cc(c1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3cccn3c2)cc1
Show InChI InChI=1S/C22H16F2N2O3S/c23-17-10-18(24)12-21(11-17)30(28,29)20-7-3-15(4-8-20)13-25-22(27)16-5-6-19-2-1-9-26(19)14-16/h1-12,14H,13H2,(H,25,27)
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n/an/a 57n/an/an/an/a7.525



Genentech, Inc. 1 DNA Way, South San Francisco, California 94080 (USA).



Assay Description
The reaction was carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well plates. NAMPT protein was added to 1 B...


Chembiochem 15: 1121-30 (2014)


Article DOI: 10.1002/cbic.201402023
BindingDB Entry DOI: 10.7270/Q2X065QR
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM112627
PNG
(GNE-201)
Show SMILES Fc1cc(F)cc(c1)S(=O)(=O)c1ccc(CNC(=O)c2ccn3cccc3c2)cc1
Show InChI InChI=1S/C22H16F2N2O3S/c23-17-11-18(24)13-21(12-17)30(28,29)20-5-3-15(4-6-20)14-25-22(27)16-7-9-26-8-1-2-19(26)10-16/h1-13H,14H2,(H,25,27)
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n/an/a 78n/an/an/an/a7.525



Genentech, Inc. 1 DNA Way, South San Francisco, California 94080 (USA).



Assay Description
The reaction was carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well plates. NAMPT protein was added to 1 B...


Chembiochem 15: 1121-30 (2014)


Article DOI: 10.1002/cbic.201402023
BindingDB Entry DOI: 10.7270/Q2X065QR
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM81396
PNG
(GMX1778)
Show SMILES Clc1ccc(OCCCCCCNC(NC#N)=Nc2ccncc2)cc1
Show InChI InChI=1S/C19H22ClN5O/c20-16-5-7-18(8-6-16)26-14-4-2-1-3-11-23-19(24-15-21)25-17-9-12-22-13-10-17/h5-10,12-13H,1-4,11,14H2,(H2,22,23,24,25)
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n/an/a 2n/an/an/an/a7.525



Genentech, Inc. 1 DNA Way, South San Francisco, California 94080 (USA).



Assay Description
The reaction was carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well plates. NAMPT protein was added to 1 B...


Chembiochem 15: 1121-30 (2014)


Article DOI: 10.1002/cbic.201402023
BindingDB Entry DOI: 10.7270/Q2X065QR
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM60806
PNG
(US9169209, Table 3, Compound 3)
Show SMILES O=C(Nc1ccc(cc1)S(=O)(=O)N1CC2CCC(C1)O2)\C=C\c1cccnc1
Show InChI InChI=1S/C20H21N3O4S/c24-20(10-3-15-2-1-11-21-12-15)22-16-4-8-19(9-5-16)28(25,26)23-13-17-6-7-18(14-23)27-17/h1-5,8-12,17-18H,6-7,13-14H2,(H,22,24)/b10-3+
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n/an/a 3n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187025
PNG
(US9169209, Table 3, Compound 58)
Show SMILES O=C(Nc1ccc(cc1)S(=O)(=O)c1cccc2Sc3ccccc3Oc12)\C=C\c1cccnc1
Show InChI InChI=1S/C26H18N2O4S2/c29-25(15-10-18-5-4-16-27-17-18)28-19-11-13-20(14-12-19)34(30,31)24-9-3-8-23-26(24)32-21-6-1-2-7-22(21)33-23/h1-17H,(H,28,29)/b15-10+
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n/an/a 7.20n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187026
PNG
(US9169209, Table 3, Compound 59)
Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)c1ccccc1)\C=C\c1cccnc1
Show InChI InChI=1S/C21H18N2O3S/c24-21(13-10-17-5-4-14-22-15-17)23-16-18-8-11-20(12-9-18)27(25,26)19-6-2-1-3-7-19/h1-15H,16H2,(H,23,24)/b13-10+
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n/an/a 3n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187027
PNG
(US9169209, Table 3, Compound 60)
Show SMILES Clc1ccc(Cl)c(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C20H14Cl2N2O3S/c21-15-4-9-18(22)19(12-15)28(26,27)17-7-5-16(6-8-17)24-20(25)10-3-14-2-1-11-23-13-14/h1-13H,(H,24,25)/b10-3+
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n/an/a 22.4n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187028
PNG
(US9169209, Table 3, Compound 61)
Show SMILES COc1ccc(C)cc1S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C22H20N2O4S/c1-16-5-11-20(28-2)21(14-16)29(26,27)19-9-7-18(8-10-19)24-22(25)12-6-17-4-3-13-23-15-17/h3-15H,1-2H3,(H,24,25)/b12-6+
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n/an/a 1.80n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187029
PNG
(US9169209, Table 3, Compound 62)
Show SMILES COc1ccccc1S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C21H18N2O4S/c1-27-19-6-2-3-7-20(19)28(25,26)18-11-9-17(10-12-18)23-21(24)13-8-16-5-4-14-22-15-16/h2-15H,1H3,(H,23,24)/b13-8+
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n/an/a 7.70n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187030
PNG
(US9169209, Table 3, Compound 63)
Show SMILES Cc1ccccc1S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C21H18N2O3S/c1-16-5-2-3-7-20(16)27(25,26)19-11-9-18(10-12-19)23-21(24)13-8-17-6-4-14-22-15-17/h2-15H,1H3,(H,23,24)/b13-8+
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n/an/a 33.3n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187031
PNG
(US9169209, Table 3, Compound 64)
Show SMILES Clc1ccc(cc1Cl)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C20H14Cl2N2O3S/c21-18-9-8-17(12-19(18)22)28(26,27)16-6-4-15(5-7-16)24-20(25)10-3-14-2-1-11-23-13-14/h1-13H,(H,24,25)/b10-3+
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n/an/a 72.9n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187032
PNG
(US9169209, Table 3, Compound 65)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C22H20N2O5S/c1-28-20-11-10-19(14-21(20)29-2)30(26,27)18-8-6-17(7-9-18)24-22(25)12-5-16-4-3-13-23-15-16/h3-15H,1-2H3,(H,24,25)/b12-5+
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n/an/a 2.5n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187033
PNG
(US9169209, Table 3, Compound 66)
Show SMILES Clc1cc(Cl)cc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C20H14Cl2N2O3S/c21-15-10-16(22)12-19(11-15)28(26,27)18-6-4-17(5-7-18)24-20(25)8-3-14-2-1-9-23-13-14/h1-13H,(H,24,25)/b8-3+
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n/an/a 50.5n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187034
PNG
(US9169209, Table 3, Compound 67)
Show SMILES COc1cc(OC)cc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C22H20N2O5S/c1-28-18-12-19(29-2)14-21(13-18)30(26,27)20-8-6-17(7-9-20)24-22(25)10-5-16-4-3-11-23-15-16/h3-15H,1-2H3,(H,24,25)/b10-5+
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n/an/a 20.3n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187035
PNG
(US9169209, Table 3, Compound 68)
Show SMILES Cc1cc(C)cc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C22H20N2O3S/c1-16-12-17(2)14-21(13-16)28(26,27)20-8-6-19(7-9-20)24-22(25)10-5-18-4-3-11-23-15-18/h3-15H,1-2H3,(H,24,25)/b10-5+
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n/an/a 17.1n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187036
PNG
(US9169209, Table 3, Compound 69)
Show SMILES COc1ccc(cc1Cl)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C21H17ClN2O4S/c1-28-20-10-9-18(13-19(20)22)29(26,27)17-7-5-16(6-8-17)24-21(25)11-4-15-3-2-12-23-14-15/h2-14H,1H3,(H,24,25)/b11-4+
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n/an/a 5.80n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187037
PNG
(US9169209, Table 3, Compound 70)
Show SMILES Cc1ccc(cc1Cl)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C21H17ClN2O3S/c1-15-4-8-19(13-20(15)22)28(26,27)18-9-6-17(7-10-18)24-21(25)11-5-16-3-2-12-23-14-16/h2-14H,1H3,(H,24,25)/b11-5+
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n/an/a 8.60n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187038
PNG
(US9169209, Table 3, Compound 71)
Show SMILES CCCOc1ccc(cc1Cl)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C23H21ClN2O4S/c1-2-14-30-22-11-10-20(15-21(22)24)31(28,29)19-8-6-18(7-9-19)26-23(27)12-5-17-4-3-13-25-16-17/h3-13,15-16H,2,14H2,1H3,(H,26,27)/b12-5+
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n/an/a 5.60n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187039
PNG
(US9169209, Table 3, Compound 72)
Show SMILES Fc1cc(Cl)cc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C20H14ClFN2O3S/c21-15-10-16(22)12-19(11-15)28(26,27)18-6-4-17(5-7-18)24-20(25)8-3-14-2-1-9-23-13-14/h1-13H,(H,24,25)/b8-3+
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n/an/a 124n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187040
PNG
(US9169209, Table 3, Compound 73)
Show SMILES COc1cc(Cl)cc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C21H17ClN2O4S/c1-28-18-11-16(22)12-20(13-18)29(26,27)19-7-5-17(6-8-19)24-21(25)9-4-15-3-2-10-23-14-15/h2-14H,1H3,(H,24,25)/b9-4+
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n/an/a 22n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187041
PNG
(US9169209, Table 3, Compound 74)
Show SMILES Cc1cc(Cl)cc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C21H17ClN2O3S/c1-15-11-17(22)13-20(12-15)28(26,27)19-7-5-18(6-8-19)24-21(25)9-4-16-3-2-10-23-14-16/h2-14H,1H3,(H,24,25)/b9-4+
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n/an/a 6.20n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187042
PNG
(US9169209, Table 3, Compound 75)
Show SMILES Clc1cccc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C20H15ClN2O3S/c21-16-4-1-5-19(13-16)27(25,26)18-9-7-17(8-10-18)23-20(24)11-6-15-3-2-12-22-14-15/h1-14H,(H,23,24)/b11-6+
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n/an/a 122n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187043
PNG
(US9169209, Table 3, Compound 76)
Show SMILES CCS(=O)(=O)Nc1cccc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C22H21N3O5S2/c1-2-31(27,28)25-19-6-3-7-21(15-19)32(29,30)20-11-9-18(10-12-20)24-22(26)13-8-17-5-4-14-23-16-17/h3-16,25H,2H2,1H3,(H,24,26)/b13-8+
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n/an/a 8.10n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187044
PNG
(US9169209, Table 3, Compound 77)
Show SMILES CCOc1cccc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C22H20N2O4S/c1-2-28-19-6-3-7-21(15-19)29(26,27)20-11-9-18(10-12-20)24-22(25)13-8-17-5-4-14-23-16-17/h3-16H,2H2,1H3,(H,24,25)/b13-8+
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n/an/a 57.2n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187045
PNG
(US9169209, Table 3, Compound 78)
Show SMILES CCc1cccc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C22H20N2O3S/c1-2-17-5-3-7-21(15-17)28(26,27)20-11-9-19(10-12-20)24-22(25)13-8-18-6-4-14-23-16-18/h3-16H,2H2,1H3,(H,24,25)/b13-8+
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n/an/a 3.30n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187046
PNG
(US9169209, Table 3, Compound 79)
Show SMILES COc1ccc(cc1F)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C21H17FN2O4S/c1-28-20-10-9-18(13-19(20)22)29(26,27)17-7-5-16(6-8-17)24-21(25)11-4-15-3-2-12-23-14-15/h2-14H,1H3,(H,24,25)/b11-4+
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n/an/a 11.5n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187047
PNG
(US9169209, Table 3, Compound 80)
Show SMILES Cc1ccc(cc1F)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C21H17FN2O3S/c1-15-4-8-19(13-20(15)22)28(26,27)18-9-6-17(7-10-18)24-21(25)11-5-16-3-2-12-23-14-16/h2-14H,1H3,(H,24,25)/b11-5+
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n/an/a 27.6n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187048
PNG
(US9169209, Table 3, Compound 81)
Show SMILES CCCOc1ccc(cc1F)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C23H21FN2O4S/c1-2-14-30-22-11-10-20(15-21(22)24)31(28,29)19-8-6-18(7-9-19)26-23(27)12-5-17-4-3-13-25-16-17/h3-13,15-16H,2,14H2,1H3,(H,26,27)/b12-5+
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n/an/a 40.9n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187049
PNG
(US9169209, Table 3, Compound 82)
Show SMILES COc1cc(F)cc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C21H17FN2O4S/c1-28-18-11-16(22)12-20(13-18)29(26,27)19-7-5-17(6-8-19)24-21(25)9-4-15-3-2-10-23-14-15/h2-14H,1H3,(H,24,25)/b9-4+
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n/an/a 3.20n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187050
PNG
(US9169209, Table 3, Compound 83)
Show SMILES Cc1cc(F)cc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C21H17FN2O3S/c1-15-11-17(22)13-20(12-15)28(26,27)19-7-5-18(6-8-19)24-21(25)9-4-16-3-2-10-23-14-16/h2-14H,1H3,(H,24,25)/b9-4+
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n/an/a 17.5n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187051
PNG
(US9169209, Table 3, Compound 84)
Show SMILES Fc1cccc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C20H15FN2O3S/c21-16-4-1-5-19(13-16)27(25,26)18-9-7-17(8-10-18)23-20(24)11-6-15-3-2-12-22-14-15/h1-14H,(H,23,24)/b11-6+
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n/an/a 66.4n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187052
PNG
(US9169209, Table 3, Compound 85)
Show SMILES CS(=O)(=O)Nc1cccc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C21H19N3O5S2/c1-30(26,27)24-18-5-2-6-20(14-18)31(28,29)19-10-8-17(9-11-19)23-21(25)12-7-16-4-3-13-22-15-16/h2-15,24H,1H3,(H,23,25)/b12-7+
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n/an/a 7.5n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187053
PNG
(US9169209, Table 3, Compound 86)
Show SMILES CS(=O)(=O)c1cccc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C21H18N2O5S2/c1-29(25,26)19-5-2-6-20(14-19)30(27,28)18-10-8-17(9-11-18)23-21(24)12-7-16-4-3-13-22-15-16/h2-15H,1H3,(H,23,24)/b12-7+
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n/an/a 14.3n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187054
PNG
(US9169209, Table 3, Compound 87)
Show SMILES COc1cccc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C21H18N2O4S/c1-27-18-5-2-6-20(14-18)28(25,26)19-10-8-17(9-11-19)23-21(24)12-7-16-4-3-13-22-15-16/h2-15H,1H3,(H,23,24)/b12-7+
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n/an/a 85.7n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187055
PNG
(US9169209, Table 3, Compound 88)
Show SMILES Cc1cccc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C21H18N2O3S/c1-16-4-2-6-20(14-16)27(25,26)19-10-8-18(9-11-19)23-21(24)12-7-17-5-3-13-22-15-17/h2-15H,1H3,(H,23,24)/b12-7+
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n/an/a 32.3n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187056
PNG
(US9169209, Table 3, Compound 89)
Show SMILES O=C(Nc1ccc(cc1)S(=O)(=O)c1cccc(c1)-c1ccccc1)\C=C\c1cccnc1
Show InChI InChI=1S/C26H20N2O3S/c29-26(16-11-20-6-5-17-27-19-20)28-23-12-14-24(15-13-23)32(30,31)25-10-4-9-22(18-25)21-7-2-1-3-8-21/h1-19H,(H,28,29)/b16-11+
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n/an/a 25.4n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187057
PNG
(US9169209, Table 3, Compound 90)
Show SMILES CCCOc1cccc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C23H22N2O4S/c1-2-15-29-20-6-3-7-22(16-20)30(27,28)21-11-9-19(10-12-21)25-23(26)13-8-18-5-4-14-24-17-18/h3-14,16-17H,2,15H2,1H3,(H,25,26)/b13-8+
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n/an/a 21.6n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187058
PNG
(US9169209, Table 3, Compound 91)
Show SMILES CCOc1cc(Cl)ccc1S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C22H19ClN2O4S/c1-2-29-20-14-17(23)6-11-21(20)30(27,28)19-9-7-18(8-10-19)25-22(26)12-5-16-4-3-13-24-15-16/h3-15H,2H2,1H3,(H,25,26)/b12-5+
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n/an/a 4.20n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187059
PNG
(US9169209, Table 3, Compound 92)
Show SMILES COc1cc(Cl)ccc1S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C21H17ClN2O4S/c1-28-19-13-16(22)5-10-20(19)29(26,27)18-8-6-17(7-9-18)24-21(25)11-4-15-3-2-12-23-14-15/h2-14H,1H3,(H,24,25)/b11-4+
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n/an/a 7.30n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187060
PNG
(US9169209, Table 3, Compound 93)
Show SMILES COc1cc(ccc1Cl)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C21H17ClN2O4S/c1-28-20-13-18(9-10-19(20)22)29(26,27)17-7-5-16(6-8-17)24-21(25)11-4-15-3-2-12-23-14-15/h2-14H,1H3,(H,24,25)/b11-4+
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n/an/a 26.3n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187061
PNG
(US9169209, Table 3, Compound 94)
Show SMILES Clc1ccc(cc1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C20H15ClN2O3S/c21-16-4-8-18(9-5-16)27(25,26)19-10-6-17(7-11-19)23-20(24)12-3-15-2-1-13-22-14-15/h1-14H,(H,23,24)/b12-3+
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n/an/a 43.5n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187062
PNG
(US9169209, Table 3, Compound 95)
Show SMILES CCOc1ccc(cc1F)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C22H19FN2O4S/c1-2-29-21-11-10-19(14-20(21)23)30(27,28)18-8-6-17(7-9-18)25-22(26)12-5-16-4-3-13-24-15-16/h3-15H,2H2,1H3,(H,25,26)/b12-5+
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n/an/a 34.1n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187063
PNG
(US9169209, Table 3, Compound 96)
Show SMILES CCOc1ccc(cc1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C22H20N2O4S/c1-2-28-19-8-12-21(13-9-19)29(26,27)20-10-6-18(7-11-20)24-22(25)14-5-17-4-3-15-23-16-17/h3-16H,2H2,1H3,(H,24,25)/b14-5+
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n/an/a 27.4n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187064
PNG
(US9169209, Table 3, Compound 97)
Show SMILES Cc1cc(ccc1F)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C21H17FN2O3S/c1-15-13-19(9-10-20(15)22)28(26,27)18-7-5-17(6-8-18)24-21(25)11-4-16-3-2-12-23-14-16/h2-14H,1H3,(H,24,25)/b11-4+
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n/an/a 21.9n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187065
PNG
(US9169209, Table 3, Compound 98)
Show SMILES Fc1ccc(cc1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C20H15FN2O3S/c21-16-4-8-18(9-5-16)27(25,26)19-10-6-17(7-11-19)23-20(24)12-3-15-2-1-13-22-14-15/h1-14H,(H,23,24)/b12-3+
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n/an/a 2n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187066
PNG
(US9169209, Table 3, Compound 99)
Show SMILES CS(=O)(=O)c1ccc(cc1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C21H18N2O5S2/c1-29(25,26)18-9-11-20(12-10-18)30(27,28)19-7-5-17(6-8-19)23-21(24)13-4-16-3-2-14-22-15-16/h2-15H,1H3,(H,23,24)/b13-4+
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n/an/a 11.4n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187067
PNG
(US9169209, Table 3, Compound 100)
Show SMILES COc1c(C)cc(cc1C)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C23H22N2O4S/c1-16-13-21(14-17(2)23(16)29-3)30(27,28)20-9-7-19(8-10-20)25-22(26)11-6-18-5-4-12-24-15-18/h4-15H,1-3H3,(H,25,26)/b11-6+
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n/an/a 6.70n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187068
PNG
(US9169209, Table 3, Compound 101)
Show SMILES COc1ccc(cc1C)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C22H20N2O4S/c1-16-14-20(10-11-21(16)28-2)29(26,27)19-8-6-18(7-9-19)24-22(25)12-5-17-4-3-13-23-15-17/h3-15H,1-2H3,(H,24,25)/b12-5+
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n/an/a 17.1n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
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