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Found 2418 hits Enz. Inhib. hit(s) with Target = 'Non-receptor tyrosine-protein kinase TYK2'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198621
PNG
(US9216999, 414 | US9556187, Example 414)
Show SMILES N#CCN(CC1CC1)C[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C20H25N7/c21-8-10-26(11-14-1-2-14)12-15-3-5-16(6-4-15)18-19-17-7-9-22-20(17)23-13-27(19)25-24-18/h7,9,13-16,22H,1-6,10-12H2/t15-,16-
PDB

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UniChem
n/an/a 110n/an/an/an/a7.5n/a



Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198624
PNG
(US9216999, 417 | US9556187, Example 417)
Show SMILES O=S(=O)(C[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12)NC1CC1
Show InChI InChI=1S/C17H22N6O2S/c24-26(25,21-13-5-6-13)9-11-1-3-12(4-2-11)15-16-14-7-8-18-17(14)19-10-23(16)22-20-15/h7-8,10-13,18,21H,1-6,9H2/t11-,12-
PDB

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UniChem
n/an/a 420n/an/an/an/a7.5n/a



Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198626
PNG
(US9216999, 419 | US9556187, Example 419)
Show SMILES O=S(=O)(C[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12)NCC#N
Show InChI InChI=1S/C16H19N7O2S/c17-6-8-20-26(24,25)9-11-1-3-12(4-2-11)14-15-13-5-7-18-16(13)19-10-23(15)22-21-14/h5,7,10-12,18,20H,1-4,8-9H2/t11-,12-
PDB

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n/an/a 270n/an/an/an/a7.5n/a



Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198629
PNG
(US9216999, 422 | US9556187, Example 422)
Show SMILES CC1(O)CN(C[C@H]2CC[C@@H](CC2)c2nnn3cnc4[nH]ccc4c23)C1
Show InChI InChI=1S/C18H24N6O/c1-18(25)9-23(10-18)8-12-2-4-13(5-3-12)15-16-14-6-7-19-17(14)20-11-24(16)22-21-15/h6-7,11-13,19,25H,2-5,8-10H2,1H3/t12-,13-
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n/an/a 130n/an/an/an/a7.5n/a



Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198631
PNG
(US9216999, 424 | US9556187, Example 424)
Show SMILES CCN(C)C1CN(C[C@H]2CC[C@@H](CC2)c2nnn3cnc4[nH]ccc4c23)C1
Show InChI InChI=1S/C20H29N7/c1-3-25(2)16-11-26(12-16)10-14-4-6-15(7-5-14)18-19-17-8-9-21-20(17)22-13-27(19)24-23-18/h8-9,13-16,21H,3-7,10-12H2,1-2H3/t14-,15-
PDB

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n/an/a>1.00E+3n/an/an/an/a7.5n/a



Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198634
PNG
(US9216999, 427 | US9556187, Example 427)
Show SMILES CS(=O)(=O)NC[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C15H20N6O2S/c1-24(22,23)18-8-10-2-4-11(5-3-10)13-14-12-6-7-16-15(12)17-9-21(14)20-19-13/h6-7,9-11,16,18H,2-5,8H2,1H3/t10-,11-
PDB

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n/an/a 16n/an/an/an/a7.5n/a



Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198636
PNG
(US9216999, 429)
Show SMILES ON=C[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C14H16N6O/c21-17-7-9-1-3-10(4-2-9)12-13-11-5-6-15-14(11)16-8-20(13)19-18-12/h5-10,15,21H,1-4H2/b17-7+/t9-,10-
PDB

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n/an/a 520n/an/an/an/a7.5n/a



Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198639
PNG
(US9216999, 432 | US9556187, Example 432)
Show SMILES N#CC(C[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12)C#N
Show InChI InChI=1S/C17H17N7/c18-8-12(9-19)7-11-1-3-13(4-2-11)15-16-14-5-6-20-17(14)21-10-24(16)23-22-15/h5-6,10-13,20H,1-4,7H2/t11-,13-
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n/an/a 67n/an/an/an/a7.5n/a



Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198641
PNG
(US9216999, 434 | US9556187, Example 434)
Show SMILES N#CC=C1CCC(CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C15H14N6/c16-7-5-10-1-3-11(4-2-10)13-14-12-6-8-17-15(12)18-9-21(14)20-19-13/h5-6,8-9,11,17H,1-4H2/b10-5-
PDB

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n/an/a 34n/an/an/an/a7.5n/a



Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198644
PNG
(US9216999, 436 | US9556187, Example 436)
Show InChI InChI=1S/C17H19N5O2/c1-2-24-14(23)9-11-3-5-12(6-4-11)15-16-13-7-8-18-17(13)19-10-22(16)21-20-15/h7-10,12,18H,2-6H2,1H3/b11-9-
PDB

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n/an/a>1.00E+3n/an/an/an/a7.5n/a



Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198646
PNG
(US9216999, 438 | US9556187, Example 438)
Show SMILES CCOC(=O)CC1CCC(CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C17H21N5O2/c1-2-24-14(23)9-11-3-5-12(6-4-11)15-16-13-7-8-18-17(13)19-10-22(16)21-20-15/h7-8,10-12,18H,2-6,9H2,1H3
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n/an/a 580n/an/an/an/a7.5n/a



Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198649
PNG
(US9216999, 440 | US9556187, Example 440)
Show SMILES N#C\C=C\[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C16H16N6/c17-8-1-2-11-3-5-12(6-4-11)14-15-13-7-9-18-16(13)19-10-22(15)21-20-14/h1-2,7,9-12,18H,3-6H2/b2-1+/t11-,12-
PDB

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n/an/a 140n/an/an/an/a7.5n/a



Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198651
PNG
(US9216999, 442a | US9556187, Example 442a)
Show SMILES FC(F)(F)CNC(=O)C[C@H]1CC[C@H](CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C17H19F3N6O/c18-17(19,20)8-22-13(27)7-10-1-3-11(4-2-10)14-15-12-5-6-21-16(12)23-9-26(15)25-24-14/h5-6,9-11,21H,1-4,7-8H2,(H,22,27)/t10-,11+
PDB

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n/an/a 790n/an/an/an/a7.5n/a



Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198654
PNG
(US9216999, 443b | US9556187, Example 443b)
Show SMILES O=C(C[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12)NCC#N
Show InChI InChI=1S/C17H19N7O/c18-6-8-19-14(25)9-11-1-3-12(4-2-11)15-16-13-5-7-20-17(13)21-10-24(16)23-22-15/h5,7,10-12,20H,1-4,8-9H2,(H,19,25)/t11-,12-
PDB

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n/an/a>1.00E+3n/an/an/an/a7.5n/a



Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198656
PNG
(US9216999, 445 | US9556187, Example 445)
Show SMILES OC12CC3CC(C1)CC(C3)(C2)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C17H19N5O/c23-17-6-10-3-11(7-17)5-16(4-10,8-17)14-13-12-1-2-18-15(12)19-9-22(13)21-20-14/h1-2,9-11,18,23H,3-8H2
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n/an/a 52n/an/an/an/a7.5n/a



Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198412
PNG
(US9216999, 209 | US9556187, Example 209)
Show SMILES F[C@H]1CCN(C1)C(=O)[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C18H21FN6O/c19-13-6-8-24(9-13)18(26)12-3-1-11(2-4-12)15-16-14-5-7-20-17(14)21-10-25(16)23-22-15/h5,7,10-13,20H,1-4,6,8-9H2/t11-,12-,13-/m0/s1
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Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198415
PNG
(US9216999, 212 | US9556187, Example 212)
Show SMILES OC(CN1CCC(CC1)c1nnn2cnc3[nH]ccc3c12)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C21H21F3N6O/c22-21(23,24)15-3-1-13(2-4-15)17(31)11-29-9-6-14(7-10-29)18-19-16-5-8-25-20(16)26-12-30(19)28-27-18/h1-5,8,12,14,17,25,31H,6-7,9-11H2
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n/an/a 450n/an/an/an/a7.5n/a



Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198417
PNG
(US9216999, 214 | US9556187, Example 214)
Show SMILES Clc1ccc(CN2CCC(CC2)c2nnn3cnc4[nH]ccc4c23)cn1
Show InChI InChI=1S/C18H18ClN7/c19-15-2-1-12(9-21-15)10-25-7-4-13(5-8-25)16-17-14-3-6-20-18(14)22-11-26(17)24-23-16/h1-3,6,9,11,13,20H,4-5,7-8,10H2
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n/an/a 290n/an/an/an/a7.5n/a



Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198420
PNG
(US9216999, 217 | US9556187, Example 217)
Show SMILES Clc1n[nH]c2ccc(CN3CCC(CC3)c3nnn4cnc5[nH]ccc5c34)cc12
Show InChI InChI=1S/C20H19ClN8/c21-19-15-9-12(1-2-16(15)24-26-19)10-28-7-4-13(5-8-28)17-18-14-3-6-22-20(14)23-11-29(18)27-25-17/h1-3,6,9,11,13,22H,4-5,7-8,10H2,(H,24,26)
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n/an/a>1.00E+3n/an/an/an/a7.5n/a



Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198422
PNG
(US9216999, 219 | US9556187, Example 219)
Show SMILES C(N1CCC(CC1)c1nnn2cnc3[nH]ccc3c12)c1cocn1
Show InChI InChI=1S/C16H17N7O/c1-4-17-16-13(1)15-14(20-21-23(15)9-18-16)11-2-5-22(6-3-11)7-12-8-24-10-19-12/h1,4,8-11,17H,2-3,5-7H2
PDB

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n/an/a 970n/an/an/an/a7.5n/a



Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198425
PNG
(US9216999, 222 | US9556187, Example 222)
Show SMILES Fc1cc(CN2CCC(CC2)c2nnn3cnc4[nH]ccc4c23)ccc1C#N
Show InChI InChI=1S/C20H18FN7/c21-17-9-13(1-2-15(17)10-22)11-27-7-4-14(5-8-27)18-19-16-3-6-23-20(16)24-12-28(19)26-25-18/h1-3,6,9,12,14,23H,4-5,7-8,11H2
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Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198427
PNG
(US9216999, 224 | US9556187, Example 224)
Show SMILES Fc1cc(cc(F)c1CN1CCC(CC1)c1nnn2cnc3[nH]ccc3c12)C(F)(F)F
Show InChI InChI=1S/C20H17F5N6/c21-15-7-12(20(23,24)25)8-16(22)14(15)9-30-5-2-11(3-6-30)17-18-13-1-4-26-19(13)27-10-31(18)29-28-17/h1,4,7-8,10-11,26H,2-3,5-6,9H2
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Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198430
PNG
(US9216999, 227 | US9556187, Example 227)
Show SMILES FC1(F)Oc2ccc(CN3CCC(CC3)c3nnn4cnc5[nH]ccc5c34)cc2O1
Show InChI InChI=1S/C20H18F2N6O2/c21-20(22)29-15-2-1-12(9-16(15)30-20)10-27-7-4-13(5-8-27)17-18-14-3-6-23-19(14)24-11-28(18)26-25-17/h1-3,6,9,11,13,23H,4-5,7-8,10H2
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Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198432
PNG
(US9216999, 229 | US9556187, Example 229)
Show SMILES FC1(F)Oc2cccc(CN3CCC(CC3)c3nnn4cnc5[nH]ccc5c34)c2O1
Show InChI InChI=1S/C20H18F2N6O2/c21-20(22)29-15-3-1-2-13(18(15)30-20)10-27-8-5-12(6-9-27)16-17-14-4-7-23-19(14)24-11-28(17)26-25-16/h1-4,7,11-12,23H,5-6,8-10H2
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Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198435
PNG
(US9216999, 232)
Show SMILES C(N1CCC(CC1)c1nnn2cnc3[nH]ccc3c12)C1=C[N]2=C(S1)C=CC=C2
Show InChI InChI=1S/C20H20N7S/c1-2-8-26-12-15(28-17(26)3-1)11-25-9-5-14(6-10-25)18-19-16-4-7-21-20(16)22-13-27(19)24-23-18/h1-4,7-8,12-14,21H,5-6,9-11H2
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Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198437
PNG
(US9216999, 234 | US9556187, Example 234)
Show SMILES C(N1CCC(CC1)c1nnn2cnc3[nH]ccc3c12)c1cnc(s1)N1CCOCC1
Show InChI InChI=1S/C20H24N8OS/c1-4-21-19-16(1)18-17(24-25-28(18)13-23-19)14-2-5-26(6-3-14)12-15-11-22-20(30-15)27-7-9-29-10-8-27/h1,4,11,13-14,21H,2-3,5-10,12H2
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Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198440
PNG
(US9216999, 237 | US9556187, Example 237)
Show SMILES Brc1csc(CN2CCC(CC2)c2nnn3cnc4[nH]ccc4c23)c1
Show InChI InChI=1S/C17H17BrN6S/c18-12-7-13(25-9-12)8-23-5-2-11(3-6-23)15-16-14-1-4-19-17(14)20-10-24(16)22-21-15/h1,4,7,9-11,19H,2-3,5-6,8H2
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Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198442
PNG
(US9216999, 239 | US9556187, Example 239)
Show SMILES C(N1CCC(CC1)c1nnn2cnc3[nH]ccc3c12)c1ccncc1
Show InChI InChI=1S/C18H19N7/c1-6-19-7-2-13(1)11-24-9-4-14(5-10-24)16-17-15-3-8-20-18(15)21-12-25(17)23-22-16/h1-3,6-8,12,14,20H,4-5,9-11H2
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Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198469
PNG
(US9216999, 266 | US9556187, Example 266)
Show SMILES OC[C@@H]1CCCN1C[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C19H26N6O/c26-11-15-2-1-9-24(15)10-13-3-5-14(6-4-13)17-18-16-7-8-20-19(16)21-12-25(18)23-22-17/h7-8,12-15,20,26H,1-6,9-11H2/t13-,14-,15-/m0/s1
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Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198472
PNG
(US9216999, 269 | US9556187, Example 269)
Show SMILES FC(F)(Br)CNC[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C16H19BrF2N6/c17-16(18,19)8-20-7-10-1-3-11(4-2-10)13-14-12-5-6-21-15(12)22-9-25(14)24-23-13/h5-6,9-11,20-21H,1-4,7-8H2/t10-,11-
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Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198474
PNG
(US9216999, 271 | US9556187, Example 271)
Show SMILES OC1CCN(C[C@H]2CC[C@@H](CC2)c2nnn3cnc4[nH]ccc4c23)CC1
Show InChI InChI=1S/C19H26N6O/c26-15-6-9-24(10-7-15)11-13-1-3-14(4-2-13)17-18-16-5-8-20-19(16)21-12-25(18)23-22-17/h5,8,12-15,20,26H,1-4,6-7,9-11H2/t13-,14-
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Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198477
PNG
(US9216999, 274 | US9556187, Example 274)
Show SMILES O=C1COc2ccc(NC[C@H]3CC[C@@H](CC3)c3nnn4cnc5[nH]ccc5c34)cc2N1
Show InChI InChI=1S/C22H23N7O2/c30-19-11-31-18-6-5-15(9-17(18)26-19)24-10-13-1-3-14(4-2-13)20-21-16-7-8-23-22(16)25-12-29(21)28-27-20/h5-9,12-14,23-24H,1-4,10-11H2,(H,26,30)/t13-,14-
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Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198479
PNG
(US9216999, 276 | US9556187, Example 276)
Show SMILES O[C@@H](CNC[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12)c1ccccc1
Show InChI InChI=1S/C22H26N6O/c29-19(16-4-2-1-3-5-16)13-23-12-15-6-8-17(9-7-15)20-21-18-10-11-24-22(18)25-14-28(21)27-26-20/h1-5,10-11,14-15,17,19,23-24,29H,6-9,12-13H2/t15-,17-,19-/m0/s1
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Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198482
PNG
(US9216999, 279 | US9556187, Example 279)
Show SMILES O=C1OCCC1NC[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C18H22N6O2/c25-18-14(6-8-26-18)20-9-11-1-3-12(4-2-11)15-16-13-5-7-19-17(13)21-10-24(16)23-22-15/h5,7,10-12,14,19-20H,1-4,6,8-9H2/t11-,12-,14?
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Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198484
PNG
(US9216999, 281 | US9556187, Example 281)
Show SMILES N#CC1CN(C[C@H]2CC[C@@H](CC2)c2nnn3cnc4[nH]ccc4c23)C1
Show InChI InChI=1S/C18H21N7/c19-7-13-9-24(10-13)8-12-1-3-14(4-2-12)16-17-15-5-6-20-18(15)21-11-25(17)23-22-16/h5-6,11-14,20H,1-4,8-10H2/t12-,14-
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Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198487
PNG
(US9216999, 284 | US9556187, Example 284)
Show SMILES C(NC1CCCC1)[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C19H26N6/c1-2-4-15(3-1)21-11-13-5-7-14(8-6-13)17-18-16-9-10-20-19(16)22-12-25(18)24-23-17/h9-10,12-15,20-21H,1-8,11H2/t13-,14-
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Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198489
PNG
(US9216999, 286 | US9556187, Example 286)
Show SMILES C([C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12)N1CCC1
Show InChI InChI=1S/C17H22N6/c1-8-22(9-1)10-12-2-4-13(5-3-12)15-16-14-6-7-18-17(14)19-11-23(16)21-20-15/h6-7,11-13,18H,1-5,8-10H2/t12-,13-
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Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198492
PNG
(US9216999, 289 | US9556187, Example 289)
Show SMILES C(NC[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12)[C@H]1CCCO1
Show InChI InChI=1S/C19H26N6O/c1-2-15(26-9-1)11-20-10-13-3-5-14(6-4-13)17-18-16-7-8-21-19(16)22-12-25(18)24-23-17/h7-8,12-15,20-21H,1-6,9-11H2/t13-,14-,15-/m1/s1
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Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198494
PNG
(US9216999, 291 | US9556187, Example 291)
Show SMILES CC1CC1NC[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C18H24N6/c1-11-8-15(11)20-9-12-2-4-13(5-3-12)16-17-14-6-7-19-18(14)21-10-24(17)23-22-16/h6-7,10-13,15,19-20H,2-5,8-9H2,1H3/t11?,12-,13-,15?
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Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198497
PNG
(US9216999, 294 | US9556187, Example 294)
Show SMILES C(NC1COC1)[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C17H22N6O/c1-3-12(4-2-11(1)7-19-13-8-24-9-13)15-16-14-5-6-18-17(14)20-10-23(16)22-21-15/h5-6,10-13,18-19H,1-4,7-9H2/t11-,12-
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Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198499
PNG
(US9216999, 296 | US9556187, Example 296)
Show SMILES CN(C)C[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C16H22N6/c1-21(2)9-11-3-5-12(6-4-11)14-15-13-7-8-17-16(13)18-10-22(15)20-19-14/h7-8,10-12,17H,3-6,9H2,1-2H3/t11-,12-
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n/an/a 190n/an/an/an/a7.5n/a



Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198502
PNG
(US9216999, 299 | US9556187, Example 299)
Show SMILES CC(C)(C)OC(=O)N[C@@H]1CCN(C[C@H]2CC[C@@H](CC2)c2nnn3cnc4[nH]ccc4c23)C1
Show InChI InChI=1S/C23H33N7O2/c1-23(2,3)32-22(31)26-17-9-11-29(13-17)12-15-4-6-16(7-5-15)19-20-18-8-10-24-21(18)25-14-30(20)28-27-19/h8,10,14-17,24H,4-7,9,11-13H2,1-3H3,(H,26,31)/t15-,16-,17-/m1/s1
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Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198504
PNG
(US9216999, 301 | US9556187, Example 301)
Show SMILES N#C[C@@H]1CCN(C[C@H]2CC[C@@H](CC2)c2nnn3cnc4[nH]ccc4c23)C1
Show InChI InChI=1S/C19H23N7/c20-9-14-6-8-25(11-14)10-13-1-3-15(4-2-13)17-18-16-5-7-21-19(16)22-12-26(18)24-23-17/h5,7,12-15,21H,1-4,6,8,10-11H2/t13-,14-,15-/m0/s1
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Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198507
PNG
(US9216999, 304)
Show SMILES OC12CC3CC(C1)C(NC[C@H]1CC[C@@H](CC1)c1nnn4cnc5[nH]ccc5c14)C(C3)C2
Show InChI InChI=1S/C24H32N6O/c31-24-9-15-7-17(10-24)20(18(8-15)11-24)26-12-14-1-3-16(4-2-14)21-22-19-5-6-25-23(19)27-13-30(22)29-28-21/h5-6,13-18,20,25-26,31H,1-4,7-12H2/t14-,15?,16-,17?,18?,20?,24?
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Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198509
PNG
(US9216999, 306 | US9556187, Example 306)
Show SMILES OCCN(C[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12)C1CCCCC1
Show InChI InChI=1S/C22H32N6O/c29-13-12-27(18-4-2-1-3-5-18)14-16-6-8-17(9-7-16)20-21-19-10-11-23-22(19)24-15-28(21)26-25-20/h10-11,15-18,23,29H,1-9,12-14H2/t16-,17-
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n/an/a 620n/an/an/an/a7.5n/a



Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198512
PNG
(US9216999, 309 | US9556187, Example 309)
Show SMILES OC1(CCN(C[C@H]2CC[C@@H](CC2)c2nnn3cnc4[nH]ccc4c23)CC1)c1ccc(Cl)c(c1)C(F)(F)F
Show InChI InChI=1S/C26H28ClF3N6O/c27-21-6-5-18(13-20(21)26(28,29)30)25(37)8-11-35(12-9-25)14-16-1-3-17(4-2-16)22-23-19-7-10-31-24(19)32-15-36(23)34-33-22/h5-7,10,13,15-17,31,37H,1-4,8-9,11-12,14H2/t16-,17-
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n/an/a 310n/an/an/an/a7.5n/a



Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198514
PNG
(US9216999, 311 | US9556187, Example 311)
Show SMILES CC(C)(O)C1CCN(C[C@H]2CC[C@@H](CC2)c2nnn3cnc4[nH]ccc4c23)CC1
Show InChI InChI=1S/C22H32N6O/c1-22(2,29)17-8-11-27(12-9-17)13-15-3-5-16(6-4-15)19-20-18-7-10-23-21(18)24-14-28(20)26-25-19/h7,10,14-17,23,29H,3-6,8-9,11-13H2,1-2H3/t15-,16-
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n/an/a 940n/an/an/an/a7.5n/a



Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198517
PNG
(US9216999, 314 | US9556187, Example 314)
Show SMILES N#CCCN1CCN(C[C@H]2CC[C@@H](CC2)c2nnn3cnc4[nH]ccc4c23)CC1
Show InChI InChI=1S/C21H28N8/c22-7-1-9-27-10-12-28(13-11-27)14-16-2-4-17(5-3-16)19-20-18-6-8-23-21(18)24-15-29(20)26-25-19/h6,8,15-17,23H,1-5,9-14H2/t16-,17-
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Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198519
PNG
(US9216999, 316 | US9556187, Example 316)
Show SMILES C(NC12CC(C1)C2)[C@H]1CC[C@@H](CC1)c1nnn2cnc3[nH]ccc3c12
Show InChI InChI=1S/C19H24N6/c1-3-14(4-2-12(1)10-22-19-7-13(8-19)9-19)16-17-15-5-6-20-18(15)21-11-25(17)24-23-16/h5-6,11-14,20,22H,1-4,7-10H2/t12-,13?,14-,19?
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Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM198522
PNG
(US9216999, 319 | US9556187, Example 319)
Show SMILES CC(=O)N[C@H]1CCN(C[C@H]2CC[C@@H](CC2)c2nnn3cnc4[nH]ccc4c23)C1
Show InChI InChI=1S/C20H27N7O/c1-13(28)23-16-7-9-26(11-16)10-14-2-4-15(5-3-14)18-19-17-6-8-21-20(17)22-12-27(19)25-24-18/h6,8,12,14-16,21H,2-5,7,9-11H2,1H3,(H,23,28)/t14-,15-,16-/m0/s1
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n/an/a>1.00E+3n/an/an/an/a7.5n/a



Nissan Chemical Industries, Ltd.

US Patent


Assay Description
JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...


US Patent US9216999 (2015)


BindingDB Entry DOI: 10.7270/Q28C9V2J
More data for this
Ligand-Target Pair
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