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Found 9566 hits Enz. Inhib. hit(s) with Target = 'P2X purinoceptor 7'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174777
PNG
(US10053462, 8 | US9102686, 8 | US9540388, 8)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4cscn4)n2C3)c1Cl
Show InChI InChI=1S/C19H15ClF3N5OS/c20-15-11(4-2-5-12(15)19(21,22)23)18(29)28-10-3-1-6-14(28)17-26-25-16(27(17)7-10)13-8-30-9-24-13/h2,4-5,8-10,14H,1,3,6-7H2/t10-,14+/m0/s1
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1.30n/a 9.70n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM174777
PNG
(US10053462, 8 | US9102686, 8 | US9540388, 8)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4cscn4)n2C3)c1Cl
Show InChI InChI=1S/C19H15ClF3N5OS/c20-15-11(4-2-5-12(15)19(21,22)23)18(29)28-10-3-1-6-14(28)17-26-25-16(27(17)7-10)13-8-30-9-24-13/h2,4-5,8-10,14H,1,3,6-7H2/t10-,14+/m0/s1
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1.30n/a 2.5n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM203334
PNG
((6r,10s)-11-[(2,3-dichloro-4-fluorophenyl)carbonyl...)
Show SMILES Fc1ccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4ccccn4)n2C3)c(Cl)c1Cl
Show InChI InChI=1S/C20H16Cl2FN5O/c21-16-12(7-8-13(23)17(16)22)20(29)28-11-4-3-6-15(28)19-26-25-18(27(19)10-11)14-5-1-2-9-24-14/h1-2,5,7-9,11,15H,3-4,6,10H2/t11-,15+/m0/s1
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2.20n/a 25n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM203334
PNG
((6r,10s)-11-[(2,3-dichloro-4-fluorophenyl)carbonyl...)
Show SMILES Fc1ccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4ccccn4)n2C3)c(Cl)c1Cl
Show InChI InChI=1S/C20H16Cl2FN5O/c21-16-12(7-8-13(23)17(16)22)20(29)28-11-4-3-6-15(28)19-26-25-18(27(19)10-11)14-5-1-2-9-24-14/h1-2,5,7-9,11,15H,3-4,6,10H2/t11-,15+/m0/s1
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2.20n/a 20n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM48901
PNG
(BDBM160086 | US10047092, 27 | US10053463, 27 | US9...)
Show SMILES C[C@H]1Cn2c(nnc2-c2ncccn2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C18H14ClF3N6O/c1-10-8-28-15(14-23-6-3-7-24-14)25-26-16(28)17(29)27(10)9-11-4-2-5-12(13(11)19)18(20,21)22/h2-7,10H,8-9H2,1H3/t10-/m0/s1
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2.5n/an/an/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Ca2+ Flux: 1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium...


US Patent US9040534 (2015)


BindingDB Entry DOI: 10.7270/Q2JS9P6W
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM203315
PNG
((6r,10s)-11-{[2-chloro-3-(trifluoromethyl)phenyl]c...)
Show SMILES Cc1ccnc(c1)-c1nnc2[C@H]3CCC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H19ClF3N5O/c1-12-8-9-27-16(10-12)19-28-29-20-17-7-2-4-13(11-30(19)20)31(17)21(32)14-5-3-6-15(18(14)23)22(24,25)26/h3,5-6,8-10,13,17H,2,4,7,11H2,1H3/t13-,17+/m0/s1
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3.10n/a 7.40n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM203315
PNG
((6r,10s)-11-{[2-chloro-3-(trifluoromethyl)phenyl]c...)
Show SMILES Cc1ccnc(c1)-c1nnc2[C@H]3CCC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H19ClF3N5O/c1-12-8-9-27-16(10-12)19-28-29-20-17-7-2-4-13(11-30(19)20)31(17)21(32)14-5-3-6-15(18(14)23)22(24,25)26/h3,5-6,8-10,13,17H,2,4,7,11H2,1H3/t13-,17+/m0/s1
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3.10n/a 17n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM203332
PNG
((6r,10s)-11-{[2-methyl-3-(trifluoromethyl)phenyl]c...)
Show SMILES Cc1c(cccc1C(F)(F)F)C(=O)N1[C@H]2CCC[C@@H]1c1nnc(-c3ccccn3)n1C2
Show InChI InChI=1S/C22H20F3N5O/c1-13-15(7-5-8-16(13)22(23,24)25)21(31)30-14-6-4-10-18(30)20-28-27-19(29(20)12-14)17-9-2-3-11-26-17/h2-3,5,7-9,11,14,18H,4,6,10,12H2,1H3/t14-,18+/m0/s1
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3.20n/a 726n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM203332
PNG
((6r,10s)-11-{[2-methyl-3-(trifluoromethyl)phenyl]c...)
Show SMILES Cc1c(cccc1C(F)(F)F)C(=O)N1[C@H]2CCC[C@@H]1c1nnc(-c3ccccn3)n1C2
Show InChI InChI=1S/C22H20F3N5O/c1-13-15(7-5-8-16(13)22(23,24)25)21(31)30-14-6-4-10-18(30)20-28-27-19(29(20)12-14)17-9-2-3-11-26-17/h2-3,5,7-9,11,14,18H,4,6,10,12H2,1H3/t14-,18+/m0/s1
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3.20n/a 14n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174802
PNG
(US10053462, 33 | US9102686, 33 | US9540388, 32)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4ccccn4)n2C3)c1Cl
Show InChI InChI=1S/C21H17ClF3N5O/c22-17-13(6-4-7-14(17)21(23,24)25)20(31)30-12-5-3-9-16(30)19-28-27-18(29(19)11-12)15-8-1-2-10-26-15/h1-2,4,6-8,10,12,16H,3,5,9,11H2/t12-,16+/m0/s1
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3.20n/a 13n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM174802
PNG
(US10053462, 33 | US9102686, 33 | US9540388, 32)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4ccccn4)n2C3)c1Cl
Show InChI InChI=1S/C21H17ClF3N5O/c22-17-13(6-4-7-14(17)21(23,24)25)20(31)30-12-5-3-9-16(30)19-28-27-18(29(19)11-12)15-8-1-2-10-26-15/h1-2,4,6-8,10,12,16H,3,5,9,11H2/t12-,16+/m0/s1
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3.20n/a 11n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM203331
PNG
((6r,10s)-11-{[2-chloro-4-fluoro-3-(trifluoromethyl...)
Show SMILES Fc1ccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4ccccn4)n2C3)c(Cl)c1C(F)(F)F
Show InChI InChI=1S/C21H16ClF4N5O/c22-17-12(7-8-13(23)16(17)21(24,25)26)20(32)31-11-4-3-6-15(31)19-29-28-18(30(19)10-11)14-5-1-2-9-27-14/h1-2,5,7-9,11,15H,3-4,6,10H2/t11-,15+/m0/s1
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3.20n/a 10n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM203331
PNG
((6r,10s)-11-{[2-chloro-4-fluoro-3-(trifluoromethyl...)
Show SMILES Fc1ccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4ccccn4)n2C3)c(Cl)c1C(F)(F)F
Show InChI InChI=1S/C21H16ClF4N5O/c22-17-12(7-8-13(23)16(17)21(24,25)26)20(32)31-11-4-3-6-15(31)19-29-28-18(30(19)10-11)14-5-1-2-9-27-14/h1-2,5,7-9,11,15H,3-4,6,10H2/t11-,15+/m0/s1
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3.20n/a 13n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM174781
PNG
(US10053462, 12 | US9102686, 12 | US9540388, 12)
Show SMILES Fc1ccc(nc1)-c1nnc2[C@@H]3CCC[C@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C21H16ClF4N5O/c22-17-13(4-2-5-14(17)21(24,25)26)20(32)31-12-3-1-6-16(31)19-29-28-18(30(19)10-12)15-8-7-11(23)9-27-15/h2,4-5,7-9,12,16H,1,3,6,10H2/t12-,16+/m1/s1
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3.40n/a 37n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174781
PNG
(US10053462, 12 | US9102686, 12 | US9540388, 12)
Show SMILES Fc1ccc(nc1)-c1nnc2[C@@H]3CCC[C@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C21H16ClF4N5O/c22-17-13(4-2-5-14(17)21(24,25)26)20(32)31-12-3-1-6-16(31)19-29-28-18(30(19)10-12)15-8-7-11(23)9-27-15/h2,4-5,7-9,12,16H,1,3,6,10H2/t12-,16+/m1/s1
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3.40n/a 13n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM174818
PNG
(US10053462, 49 | US9102686, 49 | US9540388, 49)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cscn4)n2C3)c1Cl
Show InChI InChI=1S/C18H13ClF3N5OS/c19-14-10(2-1-3-11(14)18(20,21)22)17(28)27-9-4-5-13(27)16-25-24-15(26(16)6-9)12-7-29-8-23-12/h1-3,7-9,13H,4-6H2/t9-,13+/m0/s1
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4n/a 14n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174818
PNG
(US10053462, 49 | US9102686, 49 | US9540388, 49)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cscn4)n2C3)c1Cl
Show InChI InChI=1S/C18H13ClF3N5OS/c19-14-10(2-1-3-11(14)18(20,21)22)17(28)27-9-4-5-13(27)16-25-24-15(26(16)6-9)12-7-29-8-23-12/h1-3,7-9,13H,4-6H2/t9-,13+/m0/s1
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4n/a 5n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174796
PNG
(US10053462, 27 | US9102686, 27 | US9540388, 27)
Show SMILES COc1ccnc(c1)-c1nnc2[C@@H]3CCC[C@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H19ClF3N5O2/c1-33-13-8-9-27-16(10-13)19-28-29-20-17-7-2-4-12(11-30(19)20)31(17)21(32)14-5-3-6-15(18(14)23)22(24,25)26/h3,5-6,8-10,12,17H,2,4,7,11H2,1H3/t12-,17+/m1/s1
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4n/a 1.91E+3n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM174796
PNG
(US10053462, 27 | US9102686, 27 | US9540388, 27)
Show SMILES COc1ccnc(c1)-c1nnc2[C@@H]3CCC[C@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H19ClF3N5O2/c1-33-13-8-9-27-16(10-13)19-28-29-20-17-7-2-4-12(11-30(19)20)31(17)21(32)14-5-3-6-15(18(14)23)22(24,25)26/h3,5-6,8-10,12,17H,2,4,7,11H2,1H3/t12-,17+/m1/s1
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4n/a 1.54E+3n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM174795
PNG
(US10053462, 26 | US9102686, 26 | US9540388, 26)
Show SMILES COc1ccnc(c1)-c1nnc2[C@H]3CCC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H19ClF3N5O2/c1-33-13-8-9-27-16(10-13)19-28-29-20-17-7-2-4-12(11-30(19)20)31(17)21(32)14-5-3-6-15(18(14)23)22(24,25)26/h3,5-6,8-10,12,17H,2,4,7,11H2,1H3/t12-,17+/m0/s1
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4n/a 1.40n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174795
PNG
(US10053462, 26 | US9102686, 26 | US9540388, 26)
Show SMILES COc1ccnc(c1)-c1nnc2[C@H]3CCC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H19ClF3N5O2/c1-33-13-8-9-27-16(10-13)19-28-29-20-17-7-2-4-12(11-30(19)20)31(17)21(32)14-5-3-6-15(18(14)23)22(24,25)26/h3,5-6,8-10,12,17H,2,4,7,11H2,1H3/t12-,17+/m0/s1
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4n/a 10n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM174830
PNG
(US10053462, 61 | US9102686, 61 | US9540388, 61)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cccs4)n2C3)c1Cl
Show InChI InChI=1S/C19H14ClF3N4OS/c20-15-11(3-1-4-12(15)19(21,22)23)18(28)27-10-6-7-13(27)16-24-25-17(26(16)9-10)14-5-2-8-29-14/h1-5,8,10,13H,6-7,9H2/t10-,13+/m0/s1
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4n/a 1.00E+4n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174830
PNG
(US10053462, 61 | US9102686, 61 | US9540388, 61)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cccs4)n2C3)c1Cl
Show InChI InChI=1S/C19H14ClF3N4OS/c20-15-11(3-1-4-12(15)19(21,22)23)18(28)27-10-6-7-13(27)16-24-25-17(26(16)9-10)14-5-2-8-29-14/h1-5,8,10,13H,6-7,9H2/t10-,13+/m0/s1
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4n/a 2.60n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM174772
PNG
(US10053462, 3 | US9102686, 3 | US9540388, 3)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@@H]3CCC[C@H]2c2nnc(-c4ncccn4)n2C3)c1Cl
Show InChI InChI=1S/C20H16ClF3N6O/c21-15-12(5-2-6-13(15)20(22,23)24)19(31)30-11-4-1-7-14(30)17-27-28-18(29(17)10-11)16-25-8-3-9-26-16/h2-3,5-6,8-9,11,14H,1,4,7,10H2/t11-,14+/m1/s1
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4n/a 8.10n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174772
PNG
(US10053462, 3 | US9102686, 3 | US9540388, 3)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@@H]3CCC[C@H]2c2nnc(-c4ncccn4)n2C3)c1Cl
Show InChI InChI=1S/C20H16ClF3N6O/c21-15-12(5-2-6-13(15)20(22,23)24)19(31)30-11-4-1-7-14(30)17-27-28-18(29(17)10-11)16-25-8-3-9-26-16/h2-3,5-6,8-9,11,14H,1,4,7,10H2/t11-,14+/m1/s1
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4n/a 9.60n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM203314
PNG
((6r,10s)-11-{[2-chloro-3-(trifluoromethyl)phenyl]c...)
Show SMILES Cc1nc(ccc1F)-c1nnc2[C@H]3CCC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H18ClF4N5O/c1-11-15(24)8-9-16(28-11)19-29-30-20-17-7-2-4-12(10-31(19)20)32(17)21(33)13-5-3-6-14(18(13)23)22(25,26)27/h3,5-6,8-9,12,17H,2,4,7,10H2,1H3/t12-,17+/m0/s1
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4.90n/a 41n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM203314
PNG
((6r,10s)-11-{[2-chloro-3-(trifluoromethyl)phenyl]c...)
Show SMILES Cc1nc(ccc1F)-c1nnc2[C@H]3CCC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H18ClF4N5O/c1-11-15(24)8-9-16(28-11)19-29-30-20-17-7-2-4-12(10-31(19)20)32(17)21(33)13-5-3-6-14(18(13)23)22(25,26)27/h3,5-6,8-9,12,17H,2,4,7,10H2,1H3/t12-,17+/m0/s1
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4.90n/a 31n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM203324
PNG
((6r,10s)-11-{[3-chloro-2-(trifluoromethyl)pyridin-...)
Show SMILES FC(F)(F)c1nccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4ccccn4)n2C3)c1Cl
Show InChI InChI=1S/C20H16ClF3N6O/c21-15-12(7-9-26-16(15)20(22,23)24)19(31)30-11-4-3-6-14(30)18-28-27-17(29(18)10-11)13-5-1-2-8-25-13/h1-2,5,7-9,11,14H,3-4,6,10H2/t11-,14+/m0/s1
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5n/a 30n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174793
PNG
(US10053462, 24 | US9102686, 24 | US9540388, 24)
Show SMILES Cc1cccc(n1)-c1nnc2[C@@H]3CCC[C@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H19ClF3N5O/c1-12-5-2-9-16(27-12)19-28-29-20-17-10-3-6-13(11-30(19)20)31(17)21(32)14-7-4-8-15(18(14)23)22(24,25)26/h2,4-5,7-9,13,17H,3,6,10-11H2,1H3/t13-,17+/m1/s1
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5n/a 3.70E+3n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM174792
PNG
(US10053462, 23 | US9102686, 23 | US9540388, 23)
Show SMILES Cc1cccc(n1)-c1nnc2[C@H]3CCC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H19ClF3N5O/c1-12-5-2-9-16(27-12)19-28-29-20-17-10-3-6-13(11-30(19)20)31(17)21(32)14-7-4-8-15(18(14)23)22(24,25)26/h2,4-5,7-9,13,17H,3,6,10-11H2,1H3/t13-,17+/m0/s1
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5n/a 56n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM174793
PNG
(US10053462, 24 | US9102686, 24 | US9540388, 24)
Show SMILES Cc1cccc(n1)-c1nnc2[C@@H]3CCC[C@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H19ClF3N5O/c1-12-5-2-9-16(27-12)19-28-29-20-17-10-3-6-13(11-30(19)20)31(17)21(32)14-7-4-8-15(18(14)23)22(24,25)26/h2,4-5,7-9,13,17H,3,6,10-11H2,1H3/t13-,17+/m1/s1
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5n/a>1.00E+4n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM203324
PNG
((6r,10s)-11-{[3-chloro-2-(trifluoromethyl)pyridin-...)
Show SMILES FC(F)(F)c1nccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4ccccn4)n2C3)c1Cl
Show InChI InChI=1S/C20H16ClF3N6O/c21-15-12(7-9-26-16(15)20(22,23)24)19(31)30-11-4-3-6-14(30)18-28-27-17(29(18)10-11)13-5-1-2-8-25-13/h1-2,5,7-9,11,14H,3-4,6,10H2/t11-,14+/m0/s1
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5n/a 13n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174792
PNG
(US10053462, 23 | US9102686, 23 | US9540388, 23)
Show SMILES Cc1cccc(n1)-c1nnc2[C@H]3CCC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H19ClF3N5O/c1-12-5-2-9-16(27-12)19-28-29-20-17-10-3-6-13(11-30(19)20)31(17)21(32)14-7-4-8-15(18(14)23)22(24,25)26/h2,4-5,7-9,13,17H,3,6,10-11H2,1H3/t13-,17+/m0/s1
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5n/a 40n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM203318
PNG
((6r,10s)-11-{[2-chloro-3-(trifluoromethyl)phenyl]c...)
Show SMILES FC(F)(F)c1ccnc(c1)-c1nnc2[C@H]3CCC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H16ClF6N5O/c23-17-13(4-2-5-14(17)22(27,28)29)20(35)34-12-3-1-6-16(34)19-32-31-18(33(19)10-12)15-9-11(7-8-30-15)21(24,25)26/h2,4-5,7-9,12,16H,1,3,6,10H2/t12-,16+/m0/s1
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5.80n/a 1.60n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM203318
PNG
((6r,10s)-11-{[2-chloro-3-(trifluoromethyl)phenyl]c...)
Show SMILES FC(F)(F)c1ccnc(c1)-c1nnc2[C@H]3CCC[C@@H](Cn12)N3C(=O)c1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C22H16ClF6N5O/c23-17-13(4-2-5-14(17)22(27,28)29)20(35)34-12-3-1-6-16(34)19-32-31-18(33(19)10-12)15-9-11(7-8-30-15)21(24,25)26/h2,4-5,7-9,12,16H,1,3,6,10H2/t12-,16+/m0/s1
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5.80n/a 1.70n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM203333
PNG
((6r,10s)-11-[(2,4-dichloro-3-fluorophenyl)carbonyl...)
Show SMILES Fc1c(Cl)ccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4ccccn4)n2C3)c1Cl
Show InChI InChI=1S/C20H16Cl2FN5O/c21-13-8-7-12(16(22)17(13)23)20(29)28-11-4-3-6-15(28)19-26-25-18(27(19)10-11)14-5-1-2-9-24-14/h1-2,5,7-9,11,15H,3-4,6,10H2/t11-,15+/m0/s1
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5.80n/a 18n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM203333
PNG
((6r,10s)-11-[(2,4-dichloro-3-fluorophenyl)carbonyl...)
Show SMILES Fc1c(Cl)ccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4ccccn4)n2C3)c1Cl
Show InChI InChI=1S/C20H16Cl2FN5O/c21-13-8-7-12(16(22)17(13)23)20(29)28-11-4-3-6-15(28)19-26-25-18(27(19)10-11)14-5-1-2-9-24-14/h1-2,5,7-9,11,15H,3-4,6,10H2/t11-,15+/m0/s1
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5.80n/a 462n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM203323
PNG
((6r,10s)-11-{[3-fluoro-2-(trifluoromethyl)pyridin-...)
Show SMILES Fc1c(ccnc1C(F)(F)F)C(=O)N1[C@H]2CCC[C@@H]1c1nnc(-c3ccccn3)n1C2
Show InChI InChI=1S/C20H16F4N6O/c21-15-12(7-9-26-16(15)20(22,23)24)19(31)30-11-4-3-6-14(30)18-28-27-17(29(18)10-11)13-5-1-2-8-25-13/h1-2,5,7-9,11,14H,3-4,6,10H2/t11-,14+/m0/s1
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6.20n/a 327n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM203323
PNG
((6r,10s)-11-{[3-fluoro-2-(trifluoromethyl)pyridin-...)
Show SMILES Fc1c(ccnc1C(F)(F)F)C(=O)N1[C@H]2CCC[C@@H]1c1nnc(-c3ccccn3)n1C2
Show InChI InChI=1S/C20H16F4N6O/c21-15-12(7-9-26-16(15)20(22,23)24)19(31)30-11-4-3-6-14(30)18-28-27-17(29(18)10-11)13-5-1-2-8-25-13/h1-2,5,7-9,11,14H,3-4,6,10H2/t11-,14+/m0/s1
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6.20n/a 21n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174815
PNG
(US10053462, 46 | US9102686, 46 | US9540388, 46)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ncccn4)n2C3)c1Cl
Show InChI InChI=1S/C19H14ClF3N6O/c20-14-11(3-1-4-12(14)19(21,22)23)18(30)29-10-5-6-13(29)16-26-27-17(28(16)9-10)15-24-7-2-8-25-15/h1-4,7-8,10,13H,5-6,9H2/t10-,13+/m0/s1
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6.30n/a 15n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM174815
PNG
(US10053462, 46 | US9102686, 46 | US9540388, 46)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ncccn4)n2C3)c1Cl
Show InChI InChI=1S/C19H14ClF3N6O/c20-14-11(3-1-4-12(14)19(21,22)23)18(30)29-10-5-6-13(29)16-26-27-17(28(16)9-10)15-24-7-2-8-25-15/h1-4,7-8,10,13H,5-6,9H2/t10-,13+/m0/s1
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6.30n/a 253n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174816
PNG
(US10053462, 47 | US9102686, 47 | US9540388, 47)
Show SMILES Fc1ccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cnccn4)n2C3)c(Cl)c1Cl
Show InChI InChI=1S/C18H13Cl2FN6O/c19-14-10(2-3-11(21)15(14)20)18(28)27-9-1-4-13(27)17-25-24-16(26(17)8-9)12-7-22-5-6-23-12/h2-3,5-7,9,13H,1,4,8H2/t9-,13+/m0/s1
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6.30n/a 20n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM174816
PNG
(US10053462, 47 | US9102686, 47 | US9540388, 47)
Show SMILES Fc1ccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cnccn4)n2C3)c(Cl)c1Cl
Show InChI InChI=1S/C18H13Cl2FN6O/c19-14-10(2-3-11(21)15(14)20)18(28)27-9-1-4-13(27)17-25-24-16(26(17)8-9)12-7-22-5-6-23-12/h2-3,5-7,9,13H,1,4,8H2/t9-,13+/m0/s1
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6.30n/a 1.92E+3n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174821
PNG
(US10053462, 52 | US9102686, 52 | US9540388, 52)
Show SMILES Fc1ccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cscn4)n2C3)c(Cl)c1C(F)(F)F
Show InChI InChI=1S/C18H12ClF4N5OS/c19-14-9(2-3-10(20)13(14)18(21,22)23)17(29)28-8-1-4-12(28)16-26-25-15(27(16)5-8)11-6-30-7-24-11/h2-3,6-8,12H,1,4-5H2/t8-,12+/m0/s1
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6.30n/a 10n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM174821
PNG
(US10053462, 52 | US9102686, 52 | US9540388, 52)
Show SMILES Fc1ccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cscn4)n2C3)c(Cl)c1C(F)(F)F
Show InChI InChI=1S/C18H12ClF4N5OS/c19-14-9(2-3-10(20)13(14)18(21,22)23)17(29)28-8-1-4-12(28)16-26-25-15(27(16)5-8)11-6-30-7-24-11/h2-3,6-8,12H,1,4-5H2/t8-,12+/m0/s1
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6.30n/a 131n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM174802
PNG
(US10053462, 33 | US9102686, 33 | US9540388, 32)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4ccccn4)n2C3)c1Cl
Show InChI InChI=1S/C21H17ClF3N5O/c22-17-13(6-4-7-14(17)21(23,24)25)20(31)30-12-5-3-9-16(30)19-28-27-18(29(19)11-12)15-8-1-2-10-26-15/h1-2,4,6-8,10,12,16H,3,5,9,11H2/t12-,16+/m0/s1
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6.30n/a 2.11E+3n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174802
PNG
(US10053462, 33 | US9102686, 33 | US9540388, 32)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4ccccn4)n2C3)c1Cl
Show InChI InChI=1S/C21H17ClF3N5O/c22-17-13(6-4-7-14(17)21(23,24)25)20(31)30-12-5-3-9-16(30)19-28-27-18(29(19)11-12)15-8-1-2-10-26-15/h1-2,4,6-8,10,12,16H,3,5,9,11H2/t12-,16+/m0/s1
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6.30n/a 1.51E+3n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174831
PNG
(US10053462, 62 | US9102686, 62 | US9540388, 62)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ccc[nH]4)n2C3)c1Cl
Show InChI InChI=1S/C19H15ClF3N5O/c20-15-11(3-1-4-12(15)19(21,22)23)18(29)28-10-6-7-14(28)17-26-25-16(27(17)9-10)13-5-2-8-24-13/h1-5,8,10,14,24H,6-7,9H2/t10-,14+/m0/s1
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6.30n/a 20n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM174831
PNG
(US10053462, 62 | US9102686, 62 | US9540388, 62)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ccc[nH]4)n2C3)c1Cl
Show InChI InChI=1S/C19H15ClF3N5O/c20-15-11(3-1-4-12(15)19(21,22)23)18(29)28-10-6-7-14(28)17-26-25-16(27(17)9-10)13-5-2-8-24-13/h1-5,8,10,14,24H,6-7,9H2/t10-,14+/m0/s1
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6.30n/a>1.00E+4n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM174810
PNG
(US10053462, 41 | US9102686, 41 | US9540388, 41)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ccccn4)n2C3)c1Cl
Show InChI InChI=1S/C20H15ClF3N5O/c21-16-12(4-3-5-13(16)20(22,23)24)19(30)29-11-7-8-15(29)18-27-26-17(28(18)10-11)14-6-1-2-9-25-14/h1-6,9,11,15H,7-8,10H2/t11-,15+/m0/s1
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7.90n/a 1.59E+3n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
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