BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 243 hits Enz. Inhib. hit(s) with Target = 'P70S6K (T412E)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
P70S6K (T412E)


(Homo sapiens (human))
BDBM224324
PNG
(US10080750, Compound 1 | US9321760, 1)
Show SMILES NCC(N1CCN(CC1)c1ncnc(N)c1Br)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C17H20BrF3N6/c18-14-15(23)24-10-25-16(14)27-7-5-26(6-8-27)13(9-22)11-1-3-12(4-2-11)17(19,20)21/h1-4,10,13H,5-9,22H2,(H2,23,24,25)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.80n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224325
PNG
(US10080750, Compound 2 | US9321760, 2)
Show SMILES NCC(N1CCN(CC1)c1ncnc(N)c1-c1ccc(F)cc1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C23H24F4N6/c24-18-7-3-16(4-8-18)20-21(29)30-14-31-22(20)33-11-9-32(10-12-33)19(13-28)15-1-5-17(6-2-15)23(25,26)27/h1-8,14,19H,9-13,28H2,(H2,29,30,31)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.20n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224326
PNG
(US10080750, Compound 3 | US9321760, 3)
Show SMILES NC[C@@H](N1CCN(CC1)c1ncnc(N)c1-c1ccc(F)cc1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C23H24F4N6/c24-18-7-3-16(4-8-18)20-21(29)30-14-31-22(20)33-11-9-32(10-12-33)19(13-28)15-1-5-17(6-2-15)23(25,26)27/h1-8,14,19H,9-13,28H2,(H2,29,30,31)/t19-/m1/s1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.60n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224327
PNG
(US10080750, Compound 4 | US9321760, 4)
Show SMILES NC[C@H](N1CCN(CC1)c1ncnc(N)c1-c1ccc(F)cc1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C23H24F4N6/c24-18-7-3-16(4-8-18)20-21(29)30-14-31-22(20)33-11-9-32(10-12-33)19(13-28)15-1-5-17(6-2-15)23(25,26)27/h1-8,14,19H,9-13,28H2,(H2,29,30,31)/t19-/m0/s1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.5n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224328
PNG
(US10080750, Compound 5 | US9321760, 5)
Show SMILES NCC(N1CCN(CC1)c1ncnc(N)c1Br)c1ccccc1
Show InChI InChI=1S/C16H21BrN6/c17-14-15(19)20-11-21-16(14)23-8-6-22(7-9-23)13(10-18)12-4-2-1-3-5-12/h1-5,11,13H,6-10,18H2,(H2,19,20,21)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 330n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224329
PNG
(US10080750, Compound 6 | US9321760, 6)
Show SMILES NCC(N1CCN(CC1)c1ncnc(N)c1-c1ccc(F)cc1)c1ccccc1
Show InChI InChI=1S/C22H25FN6/c23-18-8-6-17(7-9-18)20-21(25)26-15-27-22(20)29-12-10-28(11-13-29)19(14-24)16-4-2-1-3-5-16/h1-9,15,19H,10-14,24H2,(H2,25,26,27)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 6.30n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224330
PNG
(US10080750, Compound 7 | US9321760, 7)
Show SMILES NCC(N1CCN(CC1)c1ncnc(N)c1-c1cn[nH]c1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C20H23F3N8/c21-20(22,23)15-3-1-13(2-4-15)16(9-24)30-5-7-31(8-6-30)19-17(14-10-28-29-11-14)18(25)26-12-27-19/h1-4,10-12,16H,5-9,24H2,(H,28,29)(H2,25,26,27)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.80n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224331
PNG
(US10080750, Compound 8 | US9321760, 8)
Show SMILES NC[C@@H](N1CCN(CC1)c1ncnc(N)c1-c1cn[nH]c1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C20H23F3N8/c21-20(22,23)15-3-1-13(2-4-15)16(9-24)30-5-7-31(8-6-30)19-17(14-10-28-29-11-14)18(25)26-12-27-19/h1-4,10-12,16H,5-9,24H2,(H,28,29)(H2,25,26,27)/t16-/m1/s1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.40n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224332
PNG
(US10080750, Compound 9 | US9321760, 9)
Show SMILES NC[C@H](N1CCN(CC1)c1ncnc(N)c1-c1cn[nH]c1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C20H23F3N8/c21-20(22,23)15-3-1-13(2-4-15)16(9-24)30-5-7-31(8-6-30)19-17(14-10-28-29-11-14)18(25)26-12-27-19/h1-4,10-12,16H,5-9,24H2,(H,28,29)(H2,25,26,27)/t16-/m0/s1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.70n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224333
PNG
(US10080750, Compound 10 | US9321760, 10)
Show SMILES Nc1ncnc(N2CCN(CC2)C(CN2CCCC2)c2ccc(cc2)C(F)(F)F)c1-c1ccc(F)cc1
Show InChI InChI=1S/C27H30F4N6/c28-22-9-5-20(6-10-22)24-25(32)33-18-34-26(24)37-15-13-36(14-16-37)23(17-35-11-1-2-12-35)19-3-7-21(8-4-19)27(29,30)31/h3-10,18,23H,1-2,11-17H2,(H2,32,33,34)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 31n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224334
PNG
(US10080750, Compound 11 | US9321760, 11)
Show SMILES Nc1ncnc(N2CCN(CC2)C(CN2CCCCC2)c2ccc(cc2)C(F)(F)F)c1Br
Show InChI InChI=1S/C22H28BrF3N6/c23-19-20(27)28-15-29-21(19)32-12-10-31(11-13-32)18(14-30-8-2-1-3-9-30)16-4-6-17(7-5-16)22(24,25)26/h4-7,15,18H,1-3,8-14H2,(H2,27,28,29)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 280n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224335
PNG
(US10080750, Compound 12 | US9321760, 12)
Show SMILES Nc1ncnc(N2CCN(CC2)C(CN2CCCCC2)c2ccc(cc2)C(F)(F)F)c1-c1ccc(F)cc1
Show InChI InChI=1S/C28H32F4N6/c29-23-10-6-21(7-11-23)25-26(33)34-19-35-27(25)38-16-14-37(15-17-38)24(18-36-12-2-1-3-13-36)20-4-8-22(9-5-20)28(30,31)32/h4-11,19,24H,1-3,12-18H2,(H2,33,34,35)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 18n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224336
PNG
(US10080750, Compound 13 | US9321760, 13)
Show SMILES Nc1ncnc(N2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)c1-c1ccc(F)cc1
Show InChI InChI=1S/C22H21F4N5/c23-18-7-3-16(4-8-18)19-20(27)28-14-29-21(19)31-11-9-30(10-12-31)13-15-1-5-17(6-2-15)22(24,25)26/h1-8,14H,9-13H2,(H2,27,28,29)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 7.20n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224337
PNG
(US10080750, Compound 14 | US9321760, 14)
Show SMILES CN(C)CC(N1CCN(CC1)c1ncnc(N)c1Br)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C19H24BrF3N6/c1-27(2)11-15(13-3-5-14(6-4-13)19(21,22)23)28-7-9-29(10-8-28)18-16(20)17(24)25-12-26-18/h3-6,12,15H,7-11H2,1-2H3,(H2,24,25,26)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 38n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224338
PNG
(US10080750, Compound 15 | US9321760, 15)
Show SMILES CN(C)CC(N1CCN(CC1)c1ncnc(N)c1-c1ccc(F)cc1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C25H28F4N6/c1-33(2)15-21(17-3-7-19(8-4-17)25(27,28)29)34-11-13-35(14-12-34)24-22(23(30)31-16-32-24)18-5-9-20(26)10-6-18/h3-10,16,21H,11-15H2,1-2H3,(H2,30,31,32)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.90n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224339
PNG
(US10080750, Compound 16 | US9321760, 16)
Show SMILES CN(C)C[C@@H](N1CCN(CC1)c1ncnc(N)c1-c1ccc(F)cc1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C25H28F4N6/c1-33(2)15-21(17-3-7-19(8-4-17)25(27,28)29)34-11-13-35(14-12-34)24-22(23(30)31-16-32-24)18-5-9-20(26)10-6-18/h3-10,16,21H,11-15H2,1-2H3,(H2,30,31,32)/t21-/m1/s1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.90n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224340
PNG
(US10080750, Compound 17 | US9321760, 17)
Show SMILES CN(C)C[C@H](N1CCN(CC1)c1ncnc(N)c1-c1ccc(F)cc1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C25H28F4N6/c1-33(2)15-21(17-3-7-19(8-4-17)25(27,28)29)34-11-13-35(14-12-34)24-22(23(30)31-16-32-24)18-5-9-20(26)10-6-18/h3-10,16,21H,11-15H2,1-2H3,(H2,30,31,32)/t21-/m0/s1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.70n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224341
PNG
(US10080750, Compound 18 | US9321760, 18)
Show SMILES CN(C)CCNC(=O)C(N1CCN(CC1)c1ncnc(N)c1-c1ccc(F)cc1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C27H31F4N7O/c1-36(2)12-11-33-26(39)23(19-3-7-20(8-4-19)27(29,30)31)37-13-15-38(16-14-37)25-22(24(32)34-17-35-25)18-5-9-21(28)10-6-18/h3-10,17,23H,11-16H2,1-2H3,(H,33,39)(H2,32,34,35)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 18n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224342
PNG
(US10080750, Compound 19 | US9321760, 19)
Show SMILES NCC(N1CCN(CC1)c1ncnc(N)c1C=C)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C19H23F3N6/c1-2-15-17(24)25-12-26-18(15)28-9-7-27(8-10-28)16(11-23)13-3-5-14(6-4-13)19(20,21)22/h2-6,12,16H,1,7-11,23H2,(H2,24,25,26)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 19n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224343
PNG
(US10080750, Compound 20 | US9321760, 20)
Show SMILES CN(C)CC(N1CCN(CC1)c1ncnc(N)c1-c1ccc(N)nc1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C24H29F3N8/c1-33(2)14-19(16-3-6-18(7-4-16)24(25,26)27)34-9-11-35(12-10-34)23-21(22(29)31-15-32-23)17-5-8-20(28)30-13-17/h3-8,13,15,19H,9-12,14H2,1-2H3,(H2,28,30)(H2,29,31,32)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 69n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224344
PNG
(US10080750, Compound 21 | US9321760, 21)
Show SMILES CN(C)CC(N1CCN(CC1)c1ncnc(N)c1C=C)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C21H27F3N6/c1-4-17-19(25)26-14-27-20(17)30-11-9-29(10-12-30)18(13-28(2)3)15-5-7-16(8-6-15)21(22,23)24/h4-8,14,18H,1,9-13H2,2-3H3,(H2,25,26,27)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 35n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224345
PNG
(US10080750, Compound 22 | US9321760, 22)
Show SMILES CN(C)CC(N1CCN(CC1)c1ncnc(N)c1-c1ccc(cc1)C(C)(C)O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C28H35F3N6O/c1-27(2,38)21-9-7-20(8-10-21)24-25(32)33-18-34-26(24)37-15-13-36(14-16-37)23(17-35(3)4)19-5-11-22(12-6-19)28(29,30)31/h5-12,18,23,38H,13-17H2,1-4H3,(H2,32,33,34)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 20n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224346
PNG
(US10080750, Compound 23 | US9321760, 23)
Show SMILES COC(=O)c1ccc(cc1)-c1c(N)ncnc1N1CCN(CC1)C(CN(C)C)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C27H31F3N6O2/c1-34(2)16-22(18-8-10-21(11-9-18)27(28,29)30)35-12-14-36(15-13-35)25-23(24(31)32-17-33-25)19-4-6-20(7-5-19)26(37)38-3/h4-11,17,22H,12-16H2,1-3H3,(H2,31,32,33)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 12n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224347
PNG
(US10080750, Compound 24 | US9321760, 24)
Show SMILES NCC(N1CCN(CC1)c1ncnc(N)c1C1=CCCCC1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C23H29F3N6/c24-23(25,26)18-8-6-16(7-9-18)19(14-27)31-10-12-32(13-11-31)22-20(21(28)29-15-30-22)17-4-2-1-3-5-17/h4,6-9,15,19H,1-3,5,10-14,27H2,(H2,28,29,30)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.30n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224348
PNG
(US10080750, Compound 25 | US9321760, 25)
Show SMILES NCC(N1CCN(CC1)c1ncnc(N)c1C1=CCCC1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C22H27F3N6/c23-22(24,25)17-7-5-15(6-8-17)18(13-26)30-9-11-31(12-10-30)21-19(16-3-1-2-4-16)20(27)28-14-29-21/h3,5-8,14,18H,1-2,4,9-13,26H2,(H2,27,28,29)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.40n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224349
PNG
(US10080750, Compound 26 | US9321760, 26)
Show SMILES CN(C)CC(N1CCN(CC1)c1ncnc(N)c1-c1ccc(cc1)C(O)=O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C26H29F3N6O2/c1-33(2)15-21(17-7-9-20(10-8-17)26(27,28)29)34-11-13-35(14-12-34)24-22(23(30)31-16-32-24)18-3-5-19(6-4-18)25(36)37/h3-10,16,21H,11-15H2,1-2H3,(H,36,37)(H2,30,31,32)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 45n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224350
PNG
(US10080750, Compound 27 | US9321760, 27)
Show SMILES Nc1ncnc(N2CCN(CC2)C(CN2CCC2)c2ccc(cc2)C(F)(F)F)c1-c1ccc(F)cc1
Show InChI InChI=1S/C26H28F4N6/c27-21-8-4-19(5-9-21)23-24(31)32-17-33-25(23)36-14-12-35(13-15-36)22(16-34-10-1-11-34)18-2-6-20(7-3-18)26(28,29)30/h2-9,17,22H,1,10-16H2,(H2,31,32,33)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.20n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224351
PNG
(US10080750, Compound 28 | US9321760, 28)
Show SMILES CN(C)CC(N1CCN(CC1)c1ncnc(N)c1C1CC1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C22H29F3N6/c1-29(2)13-18(15-5-7-17(8-6-15)22(23,24)25)30-9-11-31(12-10-30)21-19(16-3-4-16)20(26)27-14-28-21/h5-8,14,16,18H,3-4,9-13H2,1-2H3,(H2,26,27,28)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 260n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224352
PNG
(US10080750, Compound 29 | US9321760, 29)
Show SMILES Cn1ccnc1C(N1CCN(CC1)c1ncnc(N)c1Br)c1ccccc1
Show InChI InChI=1S/C19H22BrN7/c1-25-8-7-22-19(25)16(14-5-3-2-4-6-14)26-9-11-27(12-10-26)18-15(20)17(21)23-13-24-18/h2-8,13,16H,9-12H2,1H3,(H2,21,23,24)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+3n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224353
PNG
(US10080750, Compound 30 | US9321760, 30)
Show SMILES Cn1ccnc1C(N1CCN(CC1)c1ncnc(N)c1-c1ccc(F)cc1)c1ccccc1
Show InChI InChI=1S/C25H26FN7/c1-31-12-11-28-25(31)22(19-5-3-2-4-6-19)32-13-15-33(16-14-32)24-21(23(27)29-17-30-24)18-7-9-20(26)10-8-18/h2-12,17,22H,13-16H2,1H3,(H2,27,29,30)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 34.5n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224354
PNG
(US10080750, Compound 31 | US9321760, 31)
Show SMILES COc1c(N)ncnc1N1CCN(CC1)C(CN)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C18H23F3N6O/c1-28-15-16(23)24-11-25-17(15)27-8-6-26(7-9-27)14(10-22)12-2-4-13(5-3-12)18(19,20)21/h2-5,11,14H,6-10,22H2,1H3,(H2,23,24,25)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 40n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224355
PNG
(US10080750, Compound 32 | US9321760, 32)
Show SMILES CCOc1c(N)ncnc1N1CCN(CC1)C(CN)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C19H25F3N6O/c1-2-29-16-17(24)25-12-26-18(16)28-9-7-27(8-10-28)15(11-23)13-3-5-14(6-4-13)19(20,21)22/h3-6,12,15H,2,7-11,23H2,1H3,(H2,24,25,26)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 48.5n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224356
PNG
(US10080750, Compound 33 | US9321760, 33)
Show SMILES NCC(N1CCN(CC1)c1ncnc(N)c1OCC(F)(F)F)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C19H22F6N6O/c20-18(21,22)10-32-15-16(27)28-11-29-17(15)31-7-5-30(6-8-31)14(9-26)12-1-3-13(4-2-12)19(23,24)25/h1-4,11,14H,5-10,26H2,(H2,27,28,29)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 48.5n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224357
PNG
(US10080750, Compound 34 | US9321760, 34)
Show SMILES NCC(N1CCN(CC1)c1ncnc(N)c1OCc1ccccc1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C24H27F3N6O/c25-24(26,27)19-8-6-18(7-9-19)20(14-28)32-10-12-33(13-11-32)23-21(22(29)30-16-31-23)34-15-17-4-2-1-3-5-17/h1-9,16,20H,10-15,28H2,(H2,29,30,31)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 57n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224358
PNG
(US10080750, Compound 35 | US9321760, 35)
Show SMILES NCC(N1CCN(CC1)c1ncnc(N)c1O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C17H21F3N6O/c18-17(19,20)12-3-1-11(2-4-12)13(9-21)25-5-7-26(8-6-25)16-14(27)15(22)23-10-24-16/h1-4,10,13,27H,5-9,21H2,(H2,22,23,24)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+3n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224359
PNG
(US10080750, Compound 36 | US9321760, 36)
Show SMILES NCC(N1CCN(CC1)c1ncnc(N)c1C#N)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C18H20F3N7/c19-18(20,21)13-3-1-12(2-4-13)15(10-23)27-5-7-28(8-6-27)17-14(9-22)16(24)25-11-26-17/h1-4,11,15H,5-8,10,23H2,(H2,24,25,26)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 14n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224360
PNG
(US10080750, Compound 37 | US9321760, 37)
Show SMILES NCC(N1CCN(CC1)c1ncnc(N)c1-c1cc[nH]c1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C21H24F3N7/c22-21(23,24)16-3-1-14(2-4-16)17(11-25)30-7-9-31(10-8-30)20-18(15-5-6-27-12-15)19(26)28-13-29-20/h1-6,12-13,17,27H,7-11,25H2,(H2,26,28,29)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5.80n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224361
PNG
(US10080750, Compound 38 | US9321760, 38)
Show SMILES NCC(N1CCN(CC1)c1ncnc(N)c1-c1cnoc1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C20H22F3N7O/c21-20(22,23)15-3-1-13(2-4-15)16(9-24)29-5-7-30(8-6-29)19-17(14-10-28-31-11-14)18(25)26-12-27-19/h1-4,10-12,16H,5-9,24H2,(H2,25,26,27)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 100n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224362
PNG
(US10080750, Compound 39 | US9321760, 39)
Show SMILES CCn1cc(cn1)-c1c(N)ncnc1N1CCN(CC1)C(CN)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C22H27F3N8/c1-2-33-13-16(12-30-33)19-20(27)28-14-29-21(19)32-9-7-31(8-10-32)18(11-26)15-3-5-17(6-4-15)22(23,24)25/h3-6,12-14,18H,2,7-11,26H2,1H3,(H2,27,28,29)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 12n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224363
PNG
(US10080750, Compound 40 | US9321760, 40)
Show SMILES Cn1cc(cn1)-c1c(N)ncnc1N1CCN(CC1)C(CN)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C21H25F3N8/c1-30-12-15(11-29-30)18-19(26)27-13-28-20(18)32-8-6-31(7-9-32)17(10-25)14-2-4-16(5-3-14)21(22,23)24/h2-5,11-13,17H,6-10,25H2,1H3,(H2,26,27,28)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 11n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224364
PNG
(US10080750, Compound 41 | US9321760, 41)
Show SMILES Cn1cc(cn1)-c1c(N)ncnc1N1CCN(CC1)[C@H](CN)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C21H25F3N8/c1-30-12-15(11-29-30)18-19(26)27-13-28-20(18)32-8-6-31(7-9-32)17(10-25)14-2-4-16(5-3-14)21(22,23)24/h2-5,11-13,17H,6-10,25H2,1H3,(H2,26,27,28)/t17-/m1/s1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 14n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224365
PNG
(US10080750, Compound 42 | US9321760, 42)
Show SMILES Cn1cc(cn1)-c1c(N)ncnc1N1CCN(CC1)[C@@H](CN)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C21H25F3N8/c1-30-12-15(11-29-30)18-19(26)27-13-28-20(18)32-8-6-31(7-9-32)17(10-25)14-2-4-16(5-3-14)21(22,23)24/h2-5,11-13,17H,6-10,25H2,1H3,(H2,26,27,28)/t17-/m0/s1
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 6n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224366
PNG
(US10080750, Compound 43 | US9321760, 43)
Show SMILES Cn1ccc(n1)-c1c(N)ncnc1N1CCN(CC1)C(CN)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C21H25F3N8/c1-30-7-6-16(29-30)18-19(26)27-13-28-20(18)32-10-8-31(9-11-32)17(12-25)14-2-4-15(5-3-14)21(22,23)24/h2-7,13,17H,8-12,25H2,1H3,(H2,26,27,28)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 98n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224367
PNG
(US10080750, Compound 44 | US9321760, 44)
Show SMILES Cn1ccc(n1)-c1c(N)ncnc1N1CCN(CC1)C(CNC(C)(C)C(C)(C)O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C27H37F3N8O/c1-25(2,26(3,4)39)34-16-21(18-6-8-19(9-7-18)27(28,29)30)37-12-14-38(15-13-37)24-22(23(31)32-17-33-24)20-10-11-36(5)35-20/h6-11,17,21,34,39H,12-16H2,1-5H3,(H2,31,32,33)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 150n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224368
PNG
(US10080750, Compound 45 | US9321760, 45)
Show SMILES NCC(N1CCN(CC1)c1ncnc(N)c1CN1CC(F)C1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C21H27F4N7/c22-16-10-30(11-16)12-17-19(27)28-13-29-20(17)32-7-5-31(6-8-32)18(9-26)14-1-3-15(4-2-14)21(23,24)25/h1-4,13,16,18H,5-12,26H2,(H2,27,28,29)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 210n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224369
PNG
(US10080750, Compound 46 | US9321760, 46)
Show SMILES Nc1ncnc(N2CCC(Cc3ccc(Cl)cc3)CC2)c1Br
Show InChI InChI=1S/C16H18BrClN4/c17-14-15(19)20-10-21-16(14)22-7-5-12(6-8-22)9-11-1-3-13(18)4-2-11/h1-4,10,12H,5-9H2,(H2,19,20,21)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 630n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224370
PNG
(US10080750, Compound 47 | US9321760, 47)
Show SMILES Nc1ncnc(N2CCC(Cc3ccc(cc3)C(F)(F)F)CC2)c1Br
Show InChI InChI=1S/C17H18BrF3N4/c18-14-15(22)23-10-24-16(14)25-7-5-12(6-8-25)9-11-1-3-13(4-2-11)17(19,20)21/h1-4,10,12H,5-9H2,(H2,22,23,24)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 960n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224371
PNG
(US10080750, Compound 48 | US9321760, 48)
Show SMILES Nc1ncnc(N2CCC(Cc3ccc(cc3)C(F)(F)F)CC2)c1-c1ccc(F)cc1
Show InChI InChI=1S/C23H22F4N4/c24-19-7-3-17(4-8-19)20-21(28)29-14-30-22(20)31-11-9-16(10-12-31)13-15-1-5-18(6-2-15)23(25,26)27/h1-8,14,16H,9-13H2,(H2,28,29,30)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 66n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224372
PNG
(US10080750, Compound 49 | US9321760, 49)
Show SMILES Nc1ncnc(N2CCC(Cc3ccc(Cl)cc3)CC2)c1-c1ccc(F)cc1
Show InChI InChI=1S/C22H22ClFN4/c23-18-5-1-15(2-6-18)13-16-9-11-28(12-10-16)22-20(21(25)26-14-27-22)17-3-7-19(24)8-4-17/h1-8,14,16H,9-13H2,(H2,25,26,27)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 16n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
P70S6K (T412E)


(Homo sapiens (human))
BDBM224373
PNG
(US10080750, Compound 50 | US9321760, 50)
Show SMILES Nc1ncnc(N2CCC(Cc3ccc(cc3)-c3ccc(F)cc3)CC2)c1-c1ccc(F)cc1
Show InChI InChI=1S/C28H26F2N4/c29-24-9-5-22(6-10-24)21-3-1-19(2-4-21)17-20-13-15-34(16-14-20)28-26(27(31)32-18-33-28)23-7-11-25(30)12-8-23/h1-12,18,20H,13-17H2,(H2,31,32,33)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 450n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...


US Patent US10080750 (2018)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 243 total )  |  Next  |  Last  >>
Jump to: