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Compile Data Set for Download or QSAR

Found 2443 hits Enz. Inhib. hit(s) with Target = 'PKC alpha and beta-2'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein kinase C alpha type


(Homo sapiens (human))
BDBM92596
PNG
(Sapintoxin D)
Show SMILES CCCC(=O)O[C@@]12C(C3CC(=O)C[C@@]4(O)C(C=C(C)C4=O)[C@]3(O)[C@@H](C)[C@H]1OC(=O)c1ccccc1NC)C2(C)C
Show InChI InChI=1S/C31H39NO8/c1-7-10-23(34)40-31-24(28(31,4)5)20-14-18(33)15-29(37)22(13-16(2)25(29)35)30(20,38)17(3)26(31)39-27(36)19-11-8-9-12-21(19)32-6/h8-9,11-13,17,20,22,24,26,32,37-38H,7,10,14-15H2,1-6H3/t17-,20?,22?,24?,26+,29+,30-,31-/m0/s1
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18.2 -43.1n/an/an/an/an/a7.418



National Institutes of Health



Assay Description
[3H]PDBu binding to the C1 domains of MRCK alpha/beta and PKC alpha/delta was measured using the polyethylene glycol precipitation assay.


J Biol Chem 283: 10543-9 (2008)


Article DOI: 10.1074/jbc.M707463200
BindingDB Entry DOI: 10.7270/Q2CF9NQ6
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM50107112
PNG
((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)
Show SMILES CC(C)CC(C\C=C1\CC(CO)(COC(=O)C(C)(C)C)OC1=O)CC(C)C
Show InChI InChI=1S/C22H38O5/c1-15(2)10-17(11-16(3)4)8-9-18-12-22(13-23,27-19(18)24)14-26-20(25)21(5,6)7/h9,15-17,23H,8,10-14H2,1-7H3/b18-9-
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402 -35.6n/an/an/an/an/a7.418



National Institutes of Health



Assay Description
[3H]PDBu binding to the C1 domains of MRCK alpha/beta and PKC alpha/delta was measured using the polyethylene glycol precipitation assay.


J Biol Chem 283: 10543-9 (2008)


Article DOI: 10.1074/jbc.M707463200
BindingDB Entry DOI: 10.7270/Q2CF9NQ6
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM92595
PNG
(DAG-lactone (130C045))
Show SMILES CN(C)c1ccc(\C=C2\CC(CO)(COC(=O)c3ccc(cc3)N(=O)=O)OC2=O)cc1
Show InChI InChI=1S/C22H22N2O7/c1-23(2)18-7-3-15(4-8-18)11-17-12-22(13-25,31-21(17)27)14-30-20(26)16-5-9-19(10-6-16)24(28)29/h3-11,25H,12-14H2,1-2H3/b17-11-
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4.20E+3 -30.0n/an/an/an/an/a7.418



National Institutes of Health



Assay Description
[3H]PDBu binding to the C1 domains of MRCK alpha/beta and PKC alpha/delta was measured using the polyethylene glycol precipitation assay.


J Biol Chem 283: 10543-9 (2008)


Article DOI: 10.1074/jbc.M707463200
BindingDB Entry DOI: 10.7270/Q2CF9NQ6
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM50015677
PNG
((S)-1-hydroxymethyl-2-octanoyloxy-ethyl ester | 1,...)
Show SMILES CCCCCCCC(=O)OC[C@H](CO)OC(=O)CCCCCCC
Show InChI InChI=1S/C19H36O5/c1-3-5-7-9-11-13-18(21)23-16-17(15-20)24-19(22)14-12-10-8-6-4-2/h17,20H,3-16H2,1-2H3/t17-/m0/s1
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6.70E+3 -28.8n/an/an/an/an/a7.418



National Institutes of Health



Assay Description
[3H]PDBu binding to the C1 domains of MRCK alpha/beta and PKC alpha/delta was measured using the polyethylene glycol precipitation assay.


J Biol Chem 283: 10543-9 (2008)


Article DOI: 10.1074/jbc.M707463200
BindingDB Entry DOI: 10.7270/Q2CF9NQ6
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM33968
PNG
(maleimide derivative, 10)
Show SMILES CN(C)CCOc1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc2c1
Show InChI InChI=1S/C26H23N3O3/c1-29(2)11-12-32-17-13-16-7-3-4-8-18(16)20(14-17)23-24(26(31)28-25(23)30)21-15-27-22-10-6-5-9-19(21)22/h3-10,13-15,27H,11-12H2,1-2H3,(H,28,30,31)
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n/an/a 2.20n/an/an/an/a7.423



Novartis



Assay Description
Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...


J Med Chem 52: 6193-6 (2009)


Article DOI: 10.1021/jm901108b
BindingDB Entry DOI: 10.7270/Q25X278Q
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM33969
PNG
(maleimide derivative, 11)
Show SMILES CN1CCN(CC1)c1cccc(c1)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12
Show InChI InChI=1S/C23H22N4O2/c1-26-9-11-27(12-10-26)16-6-4-5-15(13-16)20-21(23(29)25-22(20)28)18-14-24-19-8-3-2-7-17(18)19/h2-8,13-14,24H,9-12H2,1H3,(H,25,28,29)
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n/an/a 7.10n/an/an/an/a7.423



Novartis



Assay Description
Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...


J Med Chem 52: 6193-6 (2009)


Article DOI: 10.1021/jm901108b
BindingDB Entry DOI: 10.7270/Q25X278Q
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM33970
PNG
(maleimide derivative, 12)
Show SMILES CN1CCN(CC1)c1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc2c1
Show InChI InChI=1S/C27H24N4O2/c1-30-10-12-31(13-11-30)18-14-17-6-2-3-7-19(17)21(15-18)24-25(27(33)29-26(24)32)22-16-28-23-9-5-4-8-20(22)23/h2-9,14-16,28H,10-13H2,1H3,(H,29,32,33)
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n/an/a 0.900n/an/an/an/a7.423



Novartis



Assay Description
Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...


J Med Chem 52: 6193-6 (2009)


Article DOI: 10.1021/jm901108b
BindingDB Entry DOI: 10.7270/Q25X278Q
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM33971
PNG
(AEB071 | Sotrastaurin)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc2n1
Show InChI InChI=1S/C25H22N6O2/c1-30-10-12-31(13-11-30)25-27-19-9-5-3-7-16(19)22(28-25)21-20(23(32)29-24(21)33)17-14-26-18-8-4-2-6-15(17)18/h2-9,14,26H,10-13H2,1H3,(H,29,32,33)
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n/an/a 2.10n/an/an/an/a7.423



Novartis



Assay Description
Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...


J Med Chem 52: 6193-6 (2009)


Article DOI: 10.1021/jm901108b
BindingDB Entry DOI: 10.7270/Q25X278Q
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Protein kinase C alpha type


(Homo sapiens (human))
BDBM33972
PNG
(maleimide derivative, 13)
Show SMILES O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1nc(nc2ccccc12)N1CCOCC1
Show InChI InChI=1S/C24H19N5O3/c30-22-19(16-13-25-17-7-3-1-5-14(16)17)20(23(31)28-22)21-15-6-2-4-8-18(15)26-24(27-21)29-9-11-32-12-10-29/h1-8,13,25H,9-12H2,(H,28,30,31)
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n/an/a 1.50E+3n/an/an/an/a7.423



Novartis



Assay Description
Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...


J Med Chem 52: 6193-6 (2009)


Article DOI: 10.1021/jm901108b
BindingDB Entry DOI: 10.7270/Q25X278Q
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM2683
PNG
(2-[1-(3-dimethylaminopropyl)-indol-3-yl]-3-(indol-...)
Show SMILES CN(C)CCCn1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc12
Show InChI InChI=1S/C25H24N4O2/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31)
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n/an/a 1.60n/an/an/an/a7.423



Novartis



Assay Description
Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...


J Med Chem 52: 6193-6 (2009)


Article DOI: 10.1021/jm901108b
BindingDB Entry DOI: 10.7270/Q25X278Q
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM33964
PNG
(maleimide derivative, 3)
Show SMILES CN(C)CCCn1cc(C2=C(C(=O)NC2=O)c2cccc3ccccc23)c2ccccc12
Show InChI InChI=1S/C27H25N3O2/c1-29(2)15-8-16-30-17-22(20-12-5-6-14-23(20)30)25-24(26(31)28-27(25)32)21-13-7-10-18-9-3-4-11-19(18)21/h3-7,9-14,17H,8,15-16H2,1-2H3,(H,28,31,32)
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n/an/a 60n/an/an/an/a7.423



Novartis



Assay Description
Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...


J Med Chem 52: 6193-6 (2009)


Article DOI: 10.1021/jm901108b
BindingDB Entry DOI: 10.7270/Q25X278Q
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM33965
PNG
(maleimide derivative, 4)
Show SMILES CN(C)CCCn1cc(C2=C(C(=O)NC2=O)c2n[nH]c3ccccc23)c2ccccc12
Show InChI InChI=1S/C24H23N5O2/c1-28(2)12-7-13-29-14-17(15-8-4-6-11-19(15)29)20-21(24(31)25-23(20)30)22-16-9-3-5-10-18(16)26-27-22/h3-6,8-11,14H,7,12-13H2,1-2H3,(H,26,27)(H,25,30,31)
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n/an/a>315n/an/an/an/a7.423



Novartis



Assay Description
Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...


J Med Chem 52: 6193-6 (2009)


Article DOI: 10.1021/jm901108b
BindingDB Entry DOI: 10.7270/Q25X278Q
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM33966
PNG
(maleimide derivative, 5)
Show SMILES CN(C)CCCn1cc(C2=C(C(=O)NC2=O)c2csc3ccccc23)c2ccccc12
Show InChI InChI=1S/C25H23N3O2S/c1-27(2)12-7-13-28-14-18(16-8-3-5-10-20(16)28)22-23(25(30)26-24(22)29)19-15-31-21-11-6-4-9-17(19)21/h3-6,8-11,14-15H,7,12-13H2,1-2H3,(H,26,29,30)
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n/an/a 47n/an/an/an/a7.423



Novartis



Assay Description
Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...


J Med Chem 52: 6193-6 (2009)


Article DOI: 10.1021/jm901108b
BindingDB Entry DOI: 10.7270/Q25X278Q
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM33967
PNG
(maleimide derivative, 9)
Show SMILES CN(C)CCOc1cccc(c1)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12
Show InChI InChI=1S/C22H21N3O3/c1-25(2)10-11-28-15-7-5-6-14(12-15)19-20(22(27)24-21(19)26)17-13-23-18-9-4-3-8-16(17)18/h3-9,12-13,23H,10-11H2,1-2H3,(H,24,26,27)
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n/an/a 58n/an/an/an/a7.423



Novartis



Assay Description
Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...


J Med Chem 52: 6193-6 (2009)


Article DOI: 10.1021/jm901108b
BindingDB Entry DOI: 10.7270/Q25X278Q
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM33968
PNG
(maleimide derivative, 10)
Show SMILES CN(C)CCOc1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc2c1
Show InChI InChI=1S/C26H23N3O3/c1-29(2)11-12-32-17-13-16-7-3-4-8-18(16)20(14-17)23-24(26(31)28-25(23)30)21-15-27-22-10-6-5-9-19(21)22/h3-10,13-15,27H,11-12H2,1-2H3,(H,28,30,31)
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n/an/a 2.10n/an/an/an/a7.423



Novartis



Assay Description
Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...


J Med Chem 52: 6193-6 (2009)


Article DOI: 10.1021/jm901108b
BindingDB Entry DOI: 10.7270/Q25X278Q
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM33969
PNG
(maleimide derivative, 11)
Show SMILES CN1CCN(CC1)c1cccc(c1)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12
Show InChI InChI=1S/C23H22N4O2/c1-26-9-11-27(12-10-26)16-6-4-5-15(13-16)20-21(23(29)25-22(20)28)18-14-24-19-8-3-2-7-17(18)19/h2-8,13-14,24H,9-12H2,1H3,(H,25,28,29)
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n/an/a 36n/an/an/an/a7.423



Novartis



Assay Description
Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...


J Med Chem 52: 6193-6 (2009)


Article DOI: 10.1021/jm901108b
BindingDB Entry DOI: 10.7270/Q25X278Q
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM33970
PNG
(maleimide derivative, 12)
Show SMILES CN1CCN(CC1)c1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc2c1
Show InChI InChI=1S/C27H24N4O2/c1-30-10-12-31(13-11-30)18-14-17-6-2-3-7-19(17)21(15-18)24-25(27(33)29-26(24)32)22-16-28-23-9-5-4-8-20(22)23/h2-9,14-16,28H,10-13H2,1H3,(H,29,32,33)
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n/an/a 1.80n/an/an/an/a7.423



Novartis



Assay Description
Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...


J Med Chem 52: 6193-6 (2009)


Article DOI: 10.1021/jm901108b
BindingDB Entry DOI: 10.7270/Q25X278Q
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM33971
PNG
(AEB071 | Sotrastaurin)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc2n1
Show InChI InChI=1S/C25H22N6O2/c1-30-10-12-31(13-11-30)25-27-19-9-5-3-7-16(19)22(28-25)21-20(23(32)29-24(21)33)17-14-26-18-8-4-2-6-15(17)18/h2-9,14,26H,10-13H2,1H3,(H,29,32,33)
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n/an/a 2n/an/an/an/a7.423



Novartis



Assay Description
Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...


J Med Chem 52: 6193-6 (2009)


Article DOI: 10.1021/jm901108b
BindingDB Entry DOI: 10.7270/Q25X278Q
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM33972
PNG
(maleimide derivative, 13)
Show SMILES O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1nc(nc2ccccc12)N1CCOCC1
Show InChI InChI=1S/C24H19N5O3/c30-22-19(16-13-25-17-7-3-1-5-14(16)17)20(23(31)28-22)21-15-6-2-4-8-18(15)26-24(27-21)29-9-11-32-12-10-29/h1-8,13,25H,9-12H2,(H,28,30,31)
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n/an/a 1.27E+3n/an/an/an/a7.423



Novartis



Assay Description
Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...


J Med Chem 52: 6193-6 (2009)


Article DOI: 10.1021/jm901108b
BindingDB Entry DOI: 10.7270/Q25X278Q
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM50011236
PNG
(CHEMBL344314 | Isoquinoline-5-sulfonic acid (2-ami...)
Show SMILES NCCNS(=O)(=O)c1cccc2cnccc12
Show InChI InChI=1S/C11H13N3O2S/c12-5-7-14-17(15,16)11-3-1-2-9-8-13-6-4-10(9)11/h1-4,6,8,14H,5,7,12H2
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n/an/a 1.80E+4n/an/an/an/a7.430



Nagoya University School of Medicine



Assay Description
Casein kinase activities were determined under the conditions as described by Huang et al (1982).


J Biol Chem 264: 4924-7 (1989)


BindingDB Entry DOI: 10.7270/Q2K072VK
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM92673
PNG
(Isoquinolinesulfonamide, CKI-6)
Show SMILES NCCNS(=O)(=O)c1cccc2ccncc12
Show InChI InChI=1S/C11H13N3O2S/c12-5-7-14-17(15,16)11-3-1-2-9-4-6-13-8-10(9)11/h1-4,6,8,14H,5,7,12H2
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n/an/a>1.00E+6n/an/an/an/a7.430



Nagoya University School of Medicine



Assay Description
Casein kinase activities were determined under the conditions as described by Huang et al (1982).


J Biol Chem 264: 4924-7 (1989)


BindingDB Entry DOI: 10.7270/Q2K072VK
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM92674
PNG
(Isoquinolinesulfonamide, CKI-7)
Show SMILES NCCNS(=O)(=O)c1ccc(Cl)c2ccncc12
Show InChI InChI=1S/C11H12ClN3O2S/c12-10-1-2-11(18(16,17)15-6-4-13)9-7-14-5-3-8(9)10/h1-3,5,7,15H,4,6,13H2
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n/an/a>1.00E+6n/an/an/an/a7.430



Nagoya University School of Medicine



Assay Description
Casein kinase activities were determined under the conditions as described by Huang et al (1982).


J Biol Chem 264: 4924-7 (1989)


BindingDB Entry DOI: 10.7270/Q2K072VK
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM92594
PNG
(Phorbol ester (PDBU))
Show SMILES CCCC(=O)O[C@@H]1[C@H](C)[C@@]2(O)C3C=C(C)C(=O)[C@@]3(O)CC(=O)CC2C2C(C)(C)[C@@]12OC(=O)CCC
Show InChI InChI=1S/C27H38O8/c1-7-9-19(29)34-23-15(4)26(33)17(21-24(5,6)27(21,23)35-20(30)10-8-2)12-16(28)13-25(32)18(26)11-14(3)22(25)31/h11,15,17-18,21,23,32-33H,7-10,12-13H2,1-6H3/t15-,17?,18?,21?,23+,25+,26-,27-/m0/s1
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n/an/an/a 3.40n/an/an/a7.418



National Institutes of Health



Assay Description
[3H]PDBu binding to the C1 domains of MRCK alpha/beta and PKC alpha/delta was measured using the polyethylene glycol precipitation assay.


J Biol Chem 283: 10543-9 (2008)


Article DOI: 10.1074/jbc.M707463200
BindingDB Entry DOI: 10.7270/Q2CF9NQ6
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM33967
PNG
(maleimide derivative, 9)
Show SMILES CN(C)CCOc1cccc(c1)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12
Show InChI InChI=1S/C22H21N3O3/c1-25(2)10-11-28-15-7-5-6-14(12-15)19-20(22(27)24-21(19)26)17-13-23-18-9-4-3-8-16(17)18/h3-9,12-13,23H,10-11H2,1-2H3,(H,24,26,27)
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n/an/a 15n/an/an/an/a7.423



Novartis



Assay Description
Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...


J Med Chem 52: 6193-6 (2009)


Article DOI: 10.1021/jm901108b
BindingDB Entry DOI: 10.7270/Q25X278Q
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM33966
PNG
(maleimide derivative, 5)
Show SMILES CN(C)CCCn1cc(C2=C(C(=O)NC2=O)c2csc3ccccc23)c2ccccc12
Show InChI InChI=1S/C25H23N3O2S/c1-27(2)12-7-13-28-14-18(16-8-3-5-10-20(16)28)22-23(25(30)26-24(22)29)19-15-31-21-11-6-4-9-17(19)21/h3-6,8-11,14-15H,7,12-13H2,1-2H3,(H,26,29,30)
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n/an/a 73n/an/an/an/a7.423



Novartis



Assay Description
Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...


J Med Chem 52: 6193-6 (2009)


Article DOI: 10.1021/jm901108b
BindingDB Entry DOI: 10.7270/Q25X278Q
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM33965
PNG
(maleimide derivative, 4)
Show SMILES CN(C)CCCn1cc(C2=C(C(=O)NC2=O)c2n[nH]c3ccccc23)c2ccccc12
Show InChI InChI=1S/C24H23N5O2/c1-28(2)12-7-13-29-14-17(15-8-4-6-11-19(15)29)20-21(24(31)25-23(20)30)22-16-9-3-5-10-18(16)26-27-22/h3-6,8-11,14H,7,12-13H2,1-2H3,(H,26,27)(H,25,30,31)
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n/an/a>315n/an/an/an/a7.423



Novartis



Assay Description
Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...


J Med Chem 52: 6193-6 (2009)


Article DOI: 10.1021/jm901108b
BindingDB Entry DOI: 10.7270/Q25X278Q
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM2683
PNG
(2-[1-(3-dimethylaminopropyl)-indol-3-yl]-3-(indol-...)
Show SMILES CN(C)CCCn1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc12
Show InChI InChI=1S/C25H24N4O2/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31)
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n/an/a 2.30n/an/an/an/a7.423



Novartis



Assay Description
Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...


J Med Chem 52: 6193-6 (2009)


Article DOI: 10.1021/jm901108b
BindingDB Entry DOI: 10.7270/Q25X278Q
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM33964
PNG
(maleimide derivative, 3)
Show SMILES CN(C)CCCn1cc(C2=C(C(=O)NC2=O)c2cccc3ccccc23)c2ccccc12
Show InChI InChI=1S/C27H25N3O2/c1-29(2)15-8-16-30-17-22(20-12-5-6-14-23(20)30)25-24(26(31)28-27(25)32)21-13-7-10-18-9-3-4-11-19(18)21/h3-7,9-14,17H,8,15-16H2,1-2H3,(H,28,31,32)
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n/an/a 98n/an/an/an/a7.423



Novartis



Assay Description
Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...


J Med Chem 52: 6193-6 (2009)


Article DOI: 10.1021/jm901108b
BindingDB Entry DOI: 10.7270/Q25X278Q
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3211
PNG
((3R,4R)-3-[(4-hydroxybenzene)amido]azepan-4-yl 3,5...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CNCCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2ccccc2O)c(O)c1
Show InChI InChI=1S/C27H26N2O8/c30-17-9-7-15(8-10-17)26(35)29-19-14-28-11-3-6-23(19)37-27(36)16-12-21(32)24(22(33)13-16)25(34)18-4-1-2-5-20(18)31/h1-2,4-5,7-10,12-13,19,23,28,30-33H,3,6,11,14H2,(H,29,35)/t19-,23-/m1/s1
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n/an/a 3.80E+4n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3212
PNG
((3R,4R)-3-[(4-hydroxybenzene)amido]azepan-4-yl 4-[...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CNCCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2O)c(O)c1
Show InChI InChI=1S/C27H26N2O9/c30-16-8-6-14(7-9-16)26(36)29-17-13-28-10-2-5-22(17)38-27(37)15-11-20(33)24(21(34)12-15)25(35)23-18(31)3-1-4-19(23)32/h1,3-4,6-9,11-12,17,22,28,30-34H,2,5,10,13H2,(H,29,36)/t17-,22-/m1/s1
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n/an/a 7.60E+3n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM3149
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C28H26N2O10/c31-16-8-6-14(7-9-16)26(36)30-18-13-29-10-2-5-22(18)40-28(39)15-11-20(33)24(21(34)12-15)25(35)23-17(27(37)38)3-1-4-19(23)32/h1,3-4,6-9,11-12,18,22,29,31-34H,2,5,10,13H2,(H,30,36)(H,37,38)/t18-,22-/m1/s1
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n/an/a 74n/an/an/an/a7.530



Sphinx Pharmaceuticals



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


Bioorg Med Chem Lett 5: 2133-8 (1995)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q26T0JT4
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM3152
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-4-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CNC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C26H22N2O10/c29-14-6-4-12(5-7-14)24(34)28-16-10-27-11-20(16)38-26(37)13-8-18(31)22(19(32)9-13)23(33)21-15(25(35)36)2-1-3-17(21)30/h1-9,16,20,27,29-32H,10-11H2,(H,28,34)(H,35,36)/t16-,20-/m1/s1
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n/an/a 22n/an/an/an/a7.530



Sphinx Pharmaceuticals



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


Bioorg Med Chem Lett 5: 2133-8 (1995)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q26T0JT4
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM3243
PNG
((3R,4R)-4-[(4-hydroxybenzene)amido]pyrrolidin-3-yl...)
Show SMILES COC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CNC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C27H24N2O10/c1-38-27(37)16-3-2-4-18(31)22(16)24(34)23-19(32)9-14(10-20(23)33)26(36)39-21-12-28-11-17(21)29-25(35)13-5-7-15(30)8-6-13/h2-10,17,21,28,30-33H,11-12H2,1H3,(H,29,35)/t17-,21-/m1/s1
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n/an/a 250n/an/an/an/a7.530



Sphinx Pharmaceuticals



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


Bioorg Med Chem Lett 5: 2133-8 (1995)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q26T0JT4
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM3244
PNG
((3R,4R)-4-[(4-hydroxybenzene)amido]pyrrolidin-3-yl...)
Show SMILES CCOC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CNC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C28H26N2O10/c1-2-39-28(38)17-4-3-5-19(32)23(17)25(35)24-20(33)10-15(11-21(24)34)27(37)40-22-13-29-12-18(22)30-26(36)14-6-8-16(31)9-7-14/h3-11,18,22,29,31-34H,2,12-13H2,1H3,(H,30,36)/t18-,22-/m1/s1
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n/an/a 2.20E+3n/an/an/an/a7.530



Sphinx Pharmaceuticals



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


Bioorg Med Chem Lett 5: 2133-8 (1995)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q26T0JT4
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM3245
PNG
((3R,4R)-4-[(4-hydroxybenzene)amido]pyrrolidin-3-yl...)
Show SMILES CCCCOC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CNC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C30H30N2O10/c1-2-3-11-41-30(40)19-5-4-6-21(34)25(19)27(37)26-22(35)12-17(13-23(26)36)29(39)42-24-15-31-14-20(24)32-28(38)16-7-9-18(33)10-8-16/h4-10,12-13,20,24,31,33-36H,2-3,11,14-15H2,1H3,(H,32,38)/t20-,24-/m1/s1
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n/an/a 3.10E+3n/an/an/an/a7.530



Sphinx Pharmaceuticals



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


Bioorg Med Chem Lett 5: 2133-8 (1995)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q26T0JT4
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3149
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C28H26N2O10/c31-16-8-6-14(7-9-16)26(36)30-18-13-29-10-2-5-22(18)40-28(39)15-11-20(33)24(21(34)12-15)25(35)23-17(27(37)38)3-1-4-19(23)32/h1,3-4,6-9,11-12,18,22,29,31-34H,2,5,10,13H2,(H,30,36)(H,37,38)/t18-,22-/m1/s1
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n/an/a 44n/an/an/an/a7.530



Sphinx Pharmaceuticals



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


Bioorg Med Chem Lett 5: 2133-8 (1995)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q26T0JT4
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3152
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-4-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CNC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C26H22N2O10/c29-14-6-4-12(5-7-14)24(34)28-16-10-27-11-20(16)38-26(37)13-8-18(31)22(19(32)9-13)23(33)21-15(25(35)36)2-1-3-17(21)30/h1-9,16,20,27,29-32H,10-11H2,(H,28,34)(H,35,36)/t16-,20-/m1/s1
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n/an/a 33n/an/an/an/a7.530



Sphinx Pharmaceuticals



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


Bioorg Med Chem Lett 5: 2133-8 (1995)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q26T0JT4
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3243
PNG
((3R,4R)-4-[(4-hydroxybenzene)amido]pyrrolidin-3-yl...)
Show SMILES COC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CNC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C27H24N2O10/c1-38-27(37)16-3-2-4-18(31)22(16)24(34)23-19(32)9-14(10-20(23)33)26(36)39-21-12-28-11-17(21)29-25(35)13-5-7-15(30)8-6-13/h2-10,17,21,28,30-33H,11-12H2,1H3,(H,29,35)/t17-,21-/m1/s1
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n/an/a 290n/an/an/an/a7.530



Sphinx Pharmaceuticals



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


Bioorg Med Chem Lett 5: 2133-8 (1995)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q26T0JT4
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3244
PNG
((3R,4R)-4-[(4-hydroxybenzene)amido]pyrrolidin-3-yl...)
Show SMILES CCOC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CNC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C28H26N2O10/c1-2-39-28(38)17-4-3-5-19(32)23(17)25(35)24-20(33)10-15(11-21(24)34)27(37)40-22-13-29-12-18(22)30-26(36)14-6-8-16(31)9-7-14/h3-11,18,22,29,31-34H,2,12-13H2,1H3,(H,30,36)/t18-,22-/m1/s1
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n/an/a 1.00E+3n/an/an/an/a7.530



Sphinx Pharmaceuticals



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


Bioorg Med Chem Lett 5: 2133-8 (1995)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q26T0JT4
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3245
PNG
((3R,4R)-4-[(4-hydroxybenzene)amido]pyrrolidin-3-yl...)
Show SMILES CCCCOC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CNC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C30H30N2O10/c1-2-3-11-41-30(40)19-5-4-6-21(34)25(19)27(37)26-22(35)12-17(13-23(26)36)29(39)42-24-15-31-14-20(24)32-28(38)16-7-9-18(33)10-8-16/h4-10,12-13,20,24,31,33-36H,2-3,11,14-15H2,1H3,(H,32,38)/t20-,24-/m1/s1
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n/an/a 2.20E+3n/an/an/an/a7.530



Sphinx Pharmaceuticals



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


Bioorg Med Chem Lett 5: 2133-8 (1995)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q26T0JT4
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM22042
PNG
((3Z)-5-bromo-3-[3-(3-chlorophenyl)-4-oxo-2-thioxo-...)
Show SMILES Clc1cccc(c1)N1C(=S)S\C(C1=O)=C1/C(=O)Nc2ccc(Br)cc12
Show InChI InChI=1S/C17H8BrClN2O2S2/c18-8-4-5-12-11(6-8)13(15(22)20-12)14-16(23)21(17(24)25-14)10-3-1-2-9(19)7-10/h1-7H,(H,20,22)/b14-13-
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n/an/a>2.00E+5n/an/an/an/a7.522



The Rockefeller University



Assay Description
Kinase activity was assayed for autophosphorylation and phosphorylation of MBP with radio-labeled gamma-32P. IC50 values were calculated from binding...


J Med Chem 50: 3980-3 (2007)


Article DOI: 10.1021/jm070645a
BindingDB Entry DOI: 10.7270/Q2ZW1J6Z
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM22043
PNG
(N-(3-nitrophenyl)-9,10-dioxo-9,10-dihydroanthracen...)
Show SMILES [O-][N+](=O)c1cccc(NS(=O)(=O)c2ccc3C(=O)c4ccccc4C(=O)c3c2)c1
Show InChI InChI=1S/C20H12N2O6S/c23-19-15-6-1-2-7-16(15)20(24)18-11-14(8-9-17(18)19)29(27,28)21-12-4-3-5-13(10-12)22(25)26/h1-11,21H
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n/an/a 1.65E+5n/an/an/an/a7.522



The Rockefeller University



Assay Description
Kinase activity was assayed for autophosphorylation and phosphorylation of MBP with radio-labeled gamma-32P. IC50 values were calculated from binding...


J Med Chem 50: 3980-3 (2007)


Article DOI: 10.1021/jm070645a
BindingDB Entry DOI: 10.7270/Q2ZW1J6Z
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM22044
PNG
((5Z)-5-{[5-(2-chloro-5-nitrophenyl)furan-2-yl]meth...)
Show SMILES [O-][N+](=O)c1ccc(Cl)c(c1)-c1ccc(\C=C2\C(=O)NC(=O)N(CC=C)C2=O)o1
Show InChI InChI=1S/C18H12ClN3O6/c1-2-7-21-17(24)13(16(23)20-18(21)25)9-11-4-6-15(28-11)12-8-10(22(26)27)3-5-14(12)19/h2-6,8-9H,1,7H2,(H,20,23,25)/b13-9-
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n/an/a 2.05E+5n/an/an/an/a7.522



The Rockefeller University



Assay Description
Kinase activity was assayed for autophosphorylation and phosphorylation of MBP with radio-labeled gamma-32P. IC50 values were calculated from binding...


J Med Chem 50: 3980-3 (2007)


Article DOI: 10.1021/jm070645a
BindingDB Entry DOI: 10.7270/Q2ZW1J6Z
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM22045
PNG
(5-({4-[(4-chlorophenyl)sulfanyl]-3-nitrophenyl}met...)
Show SMILES [O-][N+](=O)c1cc(C=C2C(=O)NC(=O)NC2=O)ccc1Sc1ccc(Cl)cc1
Show InChI InChI=1S/C17H10ClN3O5S/c18-10-2-4-11(5-3-10)27-14-6-1-9(8-13(14)21(25)26)7-12-15(22)19-17(24)20-16(12)23/h1-8H,(H2,19,20,22,23,24)
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n/an/a>2.00E+5n/an/an/an/a7.522



The Rockefeller University



Assay Description
Kinase activity was assayed for autophosphorylation and phosphorylation of MBP with radio-labeled gamma-32P. IC50 values were calculated from binding...


J Med Chem 50: 3980-3 (2007)


Article DOI: 10.1021/jm070645a
BindingDB Entry DOI: 10.7270/Q2ZW1J6Z
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM3149
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C28H26N2O10/c31-16-8-6-14(7-9-16)26(36)30-18-13-29-10-2-5-22(18)40-28(39)15-11-20(33)24(21(34)12-15)25(35)23-17(27(37)38)3-1-4-19(23)32/h1,3-4,6-9,11-12,18,22,29,31-34H,2,5,10,13H2,(H,30,36)(H,37,38)/t18-,22-/m1/s1
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n/an/a 74n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2151-4 (1995)


Article DOI: 10.1016/j.bmcl.2004.01.050
BindingDB Entry DOI: 10.7270/Q2VH5M1B
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM3150
PNG
(2-{[2,6-dihydroxy-4-({[(1R,2R)-2-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCCC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C29H27NO10/c31-17-11-9-15(10-12-17)27(36)30-19-6-2-1-3-8-23(19)40-29(39)16-13-21(33)25(22(34)14-16)26(35)24-18(28(37)38)5-4-7-20(24)32/h4-5,7,9-14,19,23,31-34H,1-3,6,8H2,(H,30,36)(H,37,38)/t19-,23-/m1/s1
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n/an/a 270n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2151-4 (1995)


Article DOI: 10.1016/j.bmcl.2004.01.050
BindingDB Entry DOI: 10.7270/Q2VH5M1B
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM3151
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCNC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C27H24N2O10/c30-15-6-4-13(5-7-15)25(35)29-17-12-28-9-8-21(17)39-27(38)14-10-19(32)23(20(33)11-14)24(34)22-16(26(36)37)2-1-3-18(22)31/h1-7,10-11,17,21,28,30-33H,8-9,12H2,(H,29,35)(H,36,37)/t17-,21-/m1/s1
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n/an/a 5.10E+3n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2151-4 (1995)


Article DOI: 10.1016/j.bmcl.2004.01.050
BindingDB Entry DOI: 10.7270/Q2VH5M1B
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM3152
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-4-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CNC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C26H22N2O10/c29-14-6-4-12(5-7-14)24(34)28-16-10-27-11-20(16)38-26(37)13-8-18(31)22(19(32)9-13)23(33)21-15(25(35)36)2-1-3-17(21)30/h1-9,16,20,27,29-32H,10-11H2,(H,28,34)(H,35,36)/t16-,20-/m1/s1
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n/an/a 22n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2151-4 (1995)


Article DOI: 10.1016/j.bmcl.2004.01.050
BindingDB Entry DOI: 10.7270/Q2VH5M1B
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM3153
PNG
(2-{[2,6-dihydroxy-4-({[(1R,2R)-2-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C27H23NO10/c29-15-9-7-13(8-10-15)25(34)28-17-4-2-6-21(17)38-27(37)14-11-19(31)23(20(32)12-14)24(33)22-16(26(35)36)3-1-5-18(22)30/h1,3,5,7-12,17,21,29-32H,2,4,6H2,(H,28,34)(H,35,36)/t17-,21-/m1/s1
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n/an/a 40n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2151-4 (1995)


Article DOI: 10.1016/j.bmcl.2004.01.050
BindingDB Entry DOI: 10.7270/Q2VH5M1B
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3149
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C28H26N2O10/c31-16-8-6-14(7-9-16)26(36)30-18-13-29-10-2-5-22(18)40-28(39)15-11-20(33)24(21(34)12-15)25(35)23-17(27(37)38)3-1-4-19(23)32/h1,3-4,6-9,11-12,18,22,29,31-34H,2,5,10,13H2,(H,30,36)(H,37,38)/t18-,22-/m1/s1
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n/an/a 32n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2151-4 (1995)


Article DOI: 10.1016/j.bmcl.2004.01.050
BindingDB Entry DOI: 10.7270/Q2VH5M1B
More data for this
Ligand-Target Pair
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