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Compile Data Set for Download or QSAR

Found 1269 hits Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 3-kinase regulatory subunit alpha'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295129
PNG
(3-(6-Amino-5-(3-methylisoxazol-5-yl)pyridin-3-yl)-...)
Show SMILES Cc1cc(on1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCCC1(O)CCCC1
Show InChI InChI=1S/C23H28N4O4S/c1-15-5-6-18(32(29,30)26-10-9-23(28)7-3-4-8-23)13-19(15)17-12-20(22(24)25-14-17)21-11-16(2)27-31-21/h5-6,11-14,26,28H,3-4,7-10H2,1-2H3,(H2,24,25)
PDB

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n/an/a 70n/an/an/an/a7.525



Novartis AG

US Patent


Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295233
PNG
(3-(6-amino-5-(2- methyloxazol-5- yl)pyridin-3-yl)-...)
Show SMILES Cc1ncc(o1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCCO
Show InChI InChI=1S/C18H20N4O4S/c1-11-3-4-14(27(24,25)22-5-6-23)8-15(11)13-7-16(18(19)21-9-13)17-10-20-12(2)26-17/h3-4,7-10,22-23H,5-6H2,1-2H3,(H2,19,21)
PDB

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n/an/a 350n/an/an/an/a7.525



Novartis AG

US Patent


Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295234
PNG
(3-(6-amino-5-(2- methyloxazol-5- yl)pyridin-3-yl)-...)
Show SMILES Cc1ncc(o1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCCCO
Show InChI InChI=1S/C19H22N4O4S/c1-12-4-5-15(28(25,26)23-6-3-7-24)9-16(12)14-8-17(19(20)22-10-14)18-11-21-13(2)27-18/h4-5,8-11,23-24H,3,6-7H2,1-2H3,(H2,20,22)
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n/an/a 220n/an/an/an/a7.525



Novartis AG

US Patent


Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295235
PNG
(3-(6-amino-5-(2- methyloxazol-5- yl)pyridin-3-yl)-...)
Show SMILES Cc1ncc(o1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCC1(O)COC1
Show InChI InChI=1S/C20H22N4O5S/c1-12-3-4-15(30(26,27)24-9-20(25)10-28-11-20)6-16(12)14-5-17(19(21)23-7-14)18-8-22-13(2)29-18/h3-8,24-25H,9-11H2,1-2H3,(H2,21,23)
PDB

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Novartis AG

US Patent


Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295236
PNG
(3-(6-amino-5-(2- methyloxazol-5- yl)pyridin-3-yl)-...)
Show SMILES Cc1ncc(o1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCC1CCCOC1
Show InChI InChI=1S/C22H26N4O4S/c1-14-5-6-18(31(27,28)26-10-16-4-3-7-29-13-16)9-19(14)17-8-20(22(23)25-11-17)21-12-24-15(2)30-21/h5-6,8-9,11-12,16,26H,3-4,7,10,13H2,1-2H3,(H2,23,25)
PDB

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n/an/a 150n/an/an/an/a7.525



Novartis AG

US Patent


Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295237
PNG
(3-(6-amino-5-(2- methyloxazol-5- yl)pyridin-3-yl)-...)
Show SMILES Cc1ncc(o1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCC(F)(F)F
Show InChI InChI=1S/C18H17F3N4O3S/c1-10-3-4-13(29(26,27)25-9-18(19,20)21)6-14(10)12-5-15(17(22)24-7-12)16-8-23-11(2)28-16/h3-8,25H,9H2,1-2H3,(H2,22,24)
PDB

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Novartis AG

US Patent


Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295238
PNG
(3-(6-amino-5-(2- methyloxazol-5- yl)pyridin-3-yl)-...)
Show SMILES Cc1ncc(o1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCC(F)F
Show InChI InChI=1S/C18H18F2N4O3S/c1-10-3-4-13(28(25,26)24-9-17(19)20)6-14(10)12-5-15(18(21)23-7-12)16-8-22-11(2)27-16/h3-8,17,24H,9H2,1-2H3,(H2,21,23)
PDB

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n/an/a 270n/an/an/an/a7.525



Novartis AG

US Patent


Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295239
PNG
(3-(6-amino-5-(2- methyloxazol-5- yl)pyridin-3-yl)-...)
Show SMILES Cc1ncc(o1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)N[C@H]1CC[C@H](CO)CC1
Show InChI InChI=1S/C23H28N4O4S/c1-14-3-8-19(32(29,30)27-18-6-4-16(13-28)5-7-18)10-20(14)17-9-21(23(24)26-11-17)22-12-25-15(2)31-22/h3,8-12,16,18,27-28H,4-7,13H2,1-2H3,(H2,24,26)/t16-,18-
PDB

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Novartis AG

US Patent


Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295130
PNG
(3-(6-Amino-5-(3-methyl-1,2,4-oxadiazol-5-yl)pyridi...)
Show SMILES Cc1noc(n1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NC1CC(F)(F)C1
Show InChI InChI=1S/C19H19F2N5O3S/c1-10-3-4-14(30(27,28)26-13-7-19(20,21)8-13)6-15(10)12-5-16(17(22)23-9-12)18-24-11(2)25-29-18/h3-6,9,13,26H,7-8H2,1-2H3,(H2,22,23)
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n/an/a 470n/an/an/an/a7.525



Novartis AG

US Patent


Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295131
PNG
(3-(6-Amino-5-(3-methyl-1,2,4-oxadiazol-5-yl)pyridi...)
Show SMILES Cc1noc(n1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCC(C)(C)CO
Show InChI InChI=1S/C20H25N5O4S/c1-12-5-6-15(30(27,28)23-10-20(3,4)11-26)8-16(12)14-7-17(18(21)22-9-14)19-24-13(2)25-29-19/h5-9,23,26H,10-11H2,1-4H3,(H2,21,22)
PDB

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n/an/a 470n/an/an/an/a7.525



Novartis AG

US Patent


Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295132
PNG
(3-(6-Amino-5-(3-methyl-1,2,4-oxadiazol-5-yl)pyridi...)
Show SMILES Cc1noc(n1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCC1(O)CC1
Show InChI InChI=1S/C19H21N5O4S/c1-11-3-4-14(29(26,27)22-10-19(25)5-6-19)8-15(11)13-7-16(17(20)21-9-13)18-23-12(2)24-28-18/h3-4,7-9,22,25H,5-6,10H2,1-2H3,(H2,20,21)
PDB

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n/an/a 540n/an/an/an/a7.525



Novartis AG

US Patent


Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295133
PNG
(5-(5-((3-Methoxy-3-methylazetidin-yl)sulfonyl)-2-m...)
Show SMILES COC1(C)CN(C1)S(=O)(=O)c1ccc(C)c(c1)-c1cnc(N)c(c1)-c1cc(C)no1
Show InChI InChI=1S/C21H24N4O4S/c1-13-5-6-16(30(26,27)25-11-21(3,12-25)28-4)9-17(13)15-8-18(20(22)23-10-15)19-7-14(2)24-29-19/h5-10H,11-12H2,1-4H3,(H2,22,23)
PDB

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Novartis AG

US Patent


Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295134
PNG
(3-(6-Amino-5-(3-methyl-1,2,4-oxadiazol-5-yl)pyridi...)
Show SMILES Cc1noc(n1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NC(CO)C1CCOC1
Show InChI InChI=1S/C21H25N5O5S/c1-12-3-4-16(32(28,29)26-19(10-27)14-5-6-30-11-14)8-17(12)15-7-18(20(22)23-9-15)21-24-13(2)25-31-21/h3-4,7-9,14,19,26-27H,5-6,10-11H2,1-2H3,(H2,22,23)
PDB

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Novartis AG

US Patent


Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295135
PNG
(3-(6-Amino-5-(3-methylisoxazol-5-yl)pyridin-3-yl)-...)
Show SMILES CON(C)S(=O)(=O)c1ccc(C)c(c1)-c1cnc(N)c(c1)-c1cc(C)no1
Show InChI InChI=1S/C18H20N4O4S/c1-11-5-6-14(27(23,24)22(3)25-4)9-15(11)13-8-16(18(19)20-10-13)17-7-12(2)21-26-17/h5-10H,1-4H3,(H2,19,20)
PDB

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Novartis AG

US Patent


Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295136
PNG
(3-(6-Amino-5-(3-methylisoxazol-5-yl)pyridin-3-yl)-...)
Show SMILES Cc1cc(on1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCC1(CO)CCCC1
Show InChI InChI=1S/C23H28N4O4S/c1-15-5-6-18(32(29,30)26-13-23(14-28)7-3-4-8-23)11-19(15)17-10-20(22(24)25-12-17)21-9-16(2)27-31-21/h5-6,9-12,26,28H,3-4,7-8,13-14H2,1-2H3,(H2,24,25)
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n/an/a 130n/an/an/an/a7.525



Novartis AG

US Patent


Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295240
PNG
(3-(6-amino-5-(2- methyloxazol-5- yl)pyridin-3-yl)-...)
Show SMILES Cc1ncc(o1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCC1CC1
Show InChI InChI=1S/C20H22N4O3S/c1-12-3-6-16(28(25,26)24-9-14-4-5-14)8-17(12)15-7-18(20(21)23-10-15)19-11-22-13(2)27-19/h3,6-8,10-11,14,24H,4-5,9H2,1-2H3,(H2,21,23)
PDB

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Novartis AG

US Patent


Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295241
PNG
(3-(6-amino-5-(2- methyloxazol-5- yl)pyridin-3-yl)-...)
Show SMILES Cc1ncc(o1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCC1(CO)CCOCC1
Show InChI InChI=1S/C23H28N4O5S/c1-15-3-4-18(33(29,30)27-13-23(14-28)5-7-31-8-6-23)10-19(15)17-9-20(22(24)26-11-17)21-12-25-16(2)32-21/h3-4,9-12,27-28H,5-8,13-14H2,1-2H3,(H2,24,26)
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Novartis AG

US Patent


Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295242
PNG
(3-(6-amino-5-(2- methyloxazol-5- yl)pyridin-3-yl)-...)
Show SMILES Cc1ncc(o1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NC1CC1
Show InChI InChI=1S/C19H20N4O3S/c1-11-3-6-15(27(24,25)23-14-4-5-14)8-16(11)13-7-17(19(20)22-9-13)18-10-21-12(2)26-18/h3,6-10,14,23H,4-5H2,1-2H3,(H2,20,22)
PDB

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Novartis AG

US Patent


Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295243
PNG
(US10112926, Example 104.15 | rac-3-(6-amino-5-(2- ...)
Show SMILES CC(O)CNS(=O)(=O)c1ccc(C)c(c1)-c1cnc(N)c(c1)-c1cnc(C)o1
Show InChI InChI=1S/C19H22N4O4S/c1-11-4-5-15(28(25,26)23-8-12(2)24)7-16(11)14-6-17(19(20)22-9-14)18-10-21-13(3)27-18/h4-7,9-10,12,23-24H,8H2,1-3H3,(H2,20,22)
PDB

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n/an/a 190n/an/an/an/a7.525



Novartis AG

US Patent


Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295232
PNG
((+/-)trans-3-(6-amino- 5-(2-methyloxazol-5- yl)pyr...)
Show SMILES Cc1ncc(o1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NC1CCC(O)C1
Show InChI InChI=1S/C21H24N4O4S/c1-12-3-6-17(30(27,28)25-15-4-5-16(26)8-15)9-18(12)14-7-19(21(22)24-10-14)20-11-23-13(2)29-20/h3,6-7,9-11,15-16,25-26H,4-5,8H2,1-2H3,(H2,22,24)
PDB

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Novartis AG

US Patent


Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295245
PNG
(3-(6-amino-5-(5-methyl-1,3,4-thiadiazol-2-yl)pyrid...)
Show SMILES Cc1nnc(s1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCCC(C)(C)O
Show InChI InChI=1S/C20H25N5O3S2/c1-12-5-6-15(30(27,28)23-8-7-20(3,4)26)10-16(12)14-9-17(18(21)22-11-14)19-25-24-13(2)29-19/h5-6,9-11,23,26H,7-8H2,1-4H3,(H2,21,22)
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Novartis AG

US Patent


Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295246
PNG
(3-(6-amino-5-(2-methyl-2H-1,2,3-triazol-4-yl)pyrid...)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(c1)-c1cnn(C)n1)S(=O)(=O)NCCC(C)(C)O
Show InChI InChI=1S/C20H26N6O3S/c1-13-5-6-15(30(28,29)24-8-7-20(2,3)27)10-16(13)14-9-17(19(21)22-11-14)18-12-23-26(4)25-18/h5-6,9-12,24,27H,7-8H2,1-4H3,(H2,21,22)
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Novartis AG

US Patent


Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295137
PNG
((R)-1-((3-(6-Amino-5-(3-methylisoxazol-5-yl)pyridi...)
Show SMILES Cc1cc(on1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)N1CC[C@@H](O)C1
Show InChI InChI=1S/C20H22N4O4S/c1-12-3-4-16(29(26,27)24-6-5-15(25)11-24)9-17(12)14-8-18(20(21)22-10-14)19-7-13(2)23-28-19/h3-4,7-10,15,25H,5-6,11H2,1-2H3,(H2,21,22)/t15-/m1/s1
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Novartis AG

US Patent


Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295138
PNG
((R)-3-(6-Amino-5-(3-methyl-1,2,4-oxadiazol-5-yl)py...)
Show SMILES Cc1noc(n1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)N[C@@H]1CCNC(=O)C1
Show InChI InChI=1S/C20H22N6O4S/c1-11-3-4-15(31(28,29)26-14-5-6-22-18(27)8-14)9-16(11)13-7-17(19(21)23-10-13)20-24-12(2)25-30-20/h3-4,7,9-10,14,26H,5-6,8H2,1-2H3,(H2,21,23)(H,22,27)/t14-/m1/s1
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Novartis AG

US Patent


Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295139
PNG
(3-(6-Amino-5-(3-methyl-1,2,4-oxadiazol-5-yl)pyridi...)
Show SMILES Cc1noc(n1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCC1(CO)CCC1
Show InChI InChI=1S/C21H25N5O4S/c1-13-4-5-16(31(28,29)24-11-21(12-27)6-3-7-21)9-17(13)15-8-18(19(22)23-10-15)20-25-14(2)26-30-20/h4-5,8-10,24,27H,3,6-7,11-12H2,1-2H3,(H2,22,23)
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Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295140
PNG
((R)-3-(6-Amino-5-(3-methylisoxazol-5-yl)pyridin-3-...)
Show SMILES CCN1CCCC1CNS(=O)(=O)c1ccc(C)c(c1)-c1cnc(N)c(c1)-c1cc(C)no1
Show InChI InChI=1S/C23H29N5O3S/c1-4-28-9-5-6-18(28)14-26-32(29,30)19-8-7-15(2)20(12-19)17-11-21(23(24)25-13-17)22-10-16(3)27-31-22/h7-8,10-13,18,26H,4-6,9,14H2,1-3H3,(H2,24,25)
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US Patent


Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295141
PNG
(1-((3-(6-Amino-5-(3-methylisoxazol-5-yl)pyridin-3-...)
Show SMILES Cc1cc(on1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)N1CC(C)(O)C1
Show InChI InChI=1S/C20H22N4O4S/c1-12-4-5-15(29(26,27)24-10-20(3,25)11-24)8-16(12)14-7-17(19(21)22-9-14)18-6-13(2)23-28-18/h4-9,25H,10-11H2,1-3H3,(H2,21,22)
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Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295142
PNG
(3-(6-Amino-5-(3-methyl-1,2,4-oxadiazol-5-yl)pyridi...)
Show SMILES Cc1noc(n1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCCN
Show InChI InChI=1S/C17H20N6O3S/c1-10-3-4-13(27(24,25)21-6-5-18)8-14(10)12-7-15(16(19)20-9-12)17-22-11(2)23-26-17/h3-4,7-9,21H,5-6,18H2,1-2H3,(H2,19,20)
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Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295143
PNG
(3-(6-Amino-5-(3-methylisoxazol-5-yl)pyridin-3-yl)-...)
Show SMILES Cc1cc(on1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCCC1(O)CCCCC1
Show InChI InChI=1S/C24H30N4O4S/c1-16-6-7-19(33(30,31)27-11-10-24(29)8-4-3-5-9-24)14-20(16)18-13-21(23(25)26-15-18)22-12-17(2)28-32-22/h6-7,12-15,27,29H,3-5,8-11H2,1-2H3,(H2,25,26)
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Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295247
PNG
(3-(6-amino-5-(2-methyloxazol-5-yl)pyridin-3-yl)-N-...)
Show SMILES Cc1ncc(o1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NOCC(C)(C)O
Show InChI InChI=1S/C20H24N4O5S/c1-12-5-6-15(30(26,27)24-28-11-20(3,4)25)8-16(12)14-7-17(19(21)23-9-14)18-10-22-13(2)29-18/h5-10,24-25H,11H2,1-4H3,(H2,21,23)
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Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295248
PNG
(Rac-3-(6-amino-5-(3-methyl-1,2,4-oxadiazol-5-yl)py...)
Show SMILES CC(O)CNS(=O)(=O)c1ccc(C)c(c1)-c1cnc(N)c(c1)-c1nc(C)no1
Show InChI InChI=1S/C18H21N5O4S/c1-10-4-5-14(28(25,26)21-8-11(2)24)7-15(10)13-6-16(17(19)20-9-13)18-22-12(3)23-27-18/h4-7,9,11,21,24H,8H2,1-3H3,(H2,19,20)
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Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295249
PNG
(5-(6-amino-5-(3-methylisoxazol-5-yl)pyridin-3-yl)-...)
Show SMILES Cc1cc(on1)-c1cc(cnc1N)-c1cc(c(F)cc1C)S(=O)(=O)NCC(C)(C)O
Show InChI InChI=1S/C20H23FN4O4S/c1-11-5-16(21)18(30(27,28)24-10-20(3,4)26)8-14(11)13-7-15(19(22)23-9-13)17-6-12(2)25-29-17/h5-9,24,26H,10H2,1-4H3,(H2,22,23)
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Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295250
PNG
(3-(6-amino-5-(1-methyl-1H-pyrazol-3-yl)pyridin-3-y...)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(c1)-c1ccn(C)n1)S(=O)(=O)NCC(C)(C)O
Show InChI InChI=1S/C20H25N5O3S/c1-13-5-6-15(29(27,28)23-12-20(2,3)26)10-16(13)14-9-17(19(21)22-11-14)18-7-8-25(4)24-18/h5-11,23,26H,12H2,1-4H3,(H2,21,22)
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Novartis AG

US Patent


Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295251
PNG
(3-(6-amino-5-(3-methylisoxazol-5-yl)pyridin-3-yl)-...)
Show SMILES Cc1cc(on1)-c1cc(cnc1N)-c1cccc(c1)S(=O)(=O)NCC(C)(C)O
Show InChI InChI=1S/C19H22N4O4S/c1-12-7-17(27-23-12)16-9-14(10-21-18(16)20)13-5-4-6-15(8-13)28(25,26)22-11-19(2,3)24/h4-10,22,24H,11H2,1-3H3,(H2,20,21)
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Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295252
PNG
(3-(6-amino-5-(2-methyloxazol-5-yl)pyridin-3-yl)-N-...)
Show SMILES Cc1ncc(o1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)N[C@H]1CCC[C@H](O)C1
Show InChI InChI=1S/C22H26N4O4S/c1-13-6-7-18(31(28,29)26-16-4-3-5-17(27)9-16)10-19(13)15-8-20(22(23)25-11-15)21-12-24-14(2)30-21/h6-8,10-12,16-17,26-27H,3-5,9H2,1-2H3,(H2,23,25)/t16-,17-/m0/s1
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Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295253
PNG
(5-(6-amino-5-(3-methyl-1,2,4-oxadiazol-5-yl)pyridi...)
Show SMILES Cc1noc(n1)-c1cc(cnc1N)-c1cc(c(C)cc1F)S(=O)(=O)NCC(C)(C)O
Show InChI InChI=1S/C19H22FN5O4S/c1-10-5-15(20)13(7-16(10)30(27,28)23-9-19(3,4)26)12-6-14(17(21)22-8-12)18-24-11(2)25-29-18/h5-8,23,26H,9H2,1-4H3,(H2,21,22)
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US Patent


Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295201
PNG
(3-(6-Amino-5-(2-methylthiazol-5-yl)pyridin-3-yl)-4...)
Show SMILES Cc1ncc(s1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCC1COC1
Show InChI InChI=1S/C20H22N4O3S2/c1-12-3-4-16(29(25,26)24-7-14-10-27-11-14)6-17(12)15-5-18(20(21)23-8-15)19-9-22-13(2)28-19/h3-6,8-9,14,24H,7,10-11H2,1-2H3,(H2,21,23)
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Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295202
PNG
(3-(6-amino-5-(2-methylthiazol-5-yl)pyridin-3-yl)-N...)
Show SMILES Cc1ncc(s1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCC1(O)COC1
Show InChI InChI=1S/C20H22N4O4S2/c1-12-3-4-15(30(26,27)24-9-20(25)10-28-11-20)6-16(12)14-5-17(19(21)23-7-14)18-8-22-13(2)29-18/h3-8,24-25H,9-11H2,1-2H3,(H2,21,23)
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Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295203
PNG
(3-(6-Amino-5-(2-methylthiazol-5-yl)pyridin-3-yl)-N...)
Show SMILES Cc1ncc(s1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCC(C)(C)CO
Show InChI InChI=1S/C21H26N4O3S2/c1-13-5-6-16(30(27,28)25-11-21(3,4)12-26)8-17(13)15-7-18(20(22)24-9-15)19-10-23-14(2)29-19/h5-10,25-26H,11-12H2,1-4H3,(H2,22,24)
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Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295204
PNG
(3-(6-Amino-5-(2-methylthiazol-5-yl)pyridin-3-yl)-N...)
Show SMILES Cc1ncc(s1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCCO
Show InChI InChI=1S/C18H20N4O3S2/c1-11-3-4-14(27(24,25)22-5-6-23)8-15(11)13-7-16(18(19)21-9-13)17-10-20-12(2)26-17/h3-4,7-10,22-23H,5-6H2,1-2H3,(H2,19,21)
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Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295205
PNG
(US10112926, Example 84 | cis-3-(6-Amino-5-(3-methy...)
Show SMILES Cc1cc(on1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NC[C@@H]1C[C@H](O)C1
Show InChI InChI=1S/C21H24N4O4S/c1-12-3-4-17(30(27,28)24-10-14-6-16(26)7-14)9-18(12)15-8-19(21(22)23-11-15)20-5-13(2)25-29-20/h3-5,8-9,11,14,16,24,26H,6-7,10H2,1-2H3,(H2,22,23)/t14-,16+
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Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295097
PNG
(3-(6-Amino-5-(2-methylthiazol-5-yl)pyridin-3-yl)-N...)
Show SMILES Cc1ncc(s1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NC1CC2(CC(O)C2)C1
Show InChI InChI=1S/C23H26N4O3S2/c1-13-3-4-18(32(29,30)27-16-7-23(8-16)9-17(28)10-23)6-19(13)15-5-20(22(24)26-11-15)21-12-25-14(2)31-21/h3-6,11-12,16-17,27-28H,7-10H2,1-2H3,(H2,24,26)
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Novartis AG

US Patent


Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295098
PNG
(3-(6-Amino-5-(3-methyl-1,2,4-oxadiazol-5-yl)pyridi...)
Show SMILES Cc1noc(n1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCC1CCOC1
Show InChI InChI=1S/C20H23N5O4S/c1-12-3-4-16(30(26,27)23-9-14-5-6-28-11-14)8-17(12)15-7-18(19(21)22-10-15)20-24-13(2)25-29-20/h3-4,7-8,10,14,23H,5-6,9,11H2,1-2H3,(H2,21,22)
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Novartis AG

US Patent


Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295099
PNG
(3-(6-Amino-5-(1-methyl-1H-pyrazol-4-yl)pyridin-3-y...)
Show SMILES Cc1cccc(NS(=O)(=O)c2ccc(C)c(c2)-c2cnc(N)c(c2)-c2cnn(C)c2)n1
Show InChI InChI=1S/C22H22N6O2S/c1-14-7-8-18(31(29,30)27-21-6-4-5-15(2)26-21)10-19(14)16-9-20(22(23)24-11-16)17-12-25-28(3)13-17/h4-13H,1-3H3,(H2,23,24)(H,26,27)
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Novartis AG

US Patent


Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295100
PNG
(3-(6-Amino-5-(3-methylisoxazol-5-yl)pyridin-3-yl)-...)
Show SMILES Cc1cc(on1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NC1CC1
Show InChI InChI=1S/C19H20N4O3S/c1-11-3-6-15(27(24,25)23-14-4-5-14)9-16(11)13-8-17(19(20)21-10-13)18-7-12(2)22-26-18/h3,6-10,14,23H,4-5H2,1-2H3,(H2,20,21)
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Novartis AG

US Patent


Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295101
PNG
(3-(6-Amino-5-(3-methylisoxazol-5-yl)pyridin-3-yl)-...)
Show SMILES Cc1cc(on1)-c1cc(cnc1N)-c1cc(ccc1C)S(N)(=O)=O
Show InChI InChI=1S/C16H16N4O3S/c1-9-3-4-12(24(18,21)22)7-13(9)11-6-14(16(17)19-8-11)15-5-10(2)20-23-15/h3-8H,1-2H3,(H2,17,19)(H2,18,21,22)
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Novartis AG

US Patent


Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295102
PNG
(3-(6-Amino-5-(2-methyloxazol-5-yl)pyridin-3-yl)-4-...)
Show SMILES Cc1ncc(o1)-c1cc(cnc1N)-c1cc(ccc1C)S(N)(=O)=O
Show InChI InChI=1S/C16H16N4O3S/c1-9-3-4-12(24(18,21)22)6-13(9)11-5-14(16(17)20-7-11)15-8-19-10(2)23-15/h3-8H,1-2H3,(H2,17,20)(H2,18,21,22)
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Novartis AG

US Patent


Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295206
PNG
(5-(6-Amino-5-(3-methyl-1,2,4-oxadiazol-5-yl)pyridi...)
Show SMILES Cc1noc(n1)-c1cc(cnc1N)-c1cc(c(F)cc1C)S(=O)(=O)NCC(C)(C)O
Show InChI InChI=1S/C19H22FN5O4S/c1-10-5-15(20)16(30(27,28)23-9-19(3,4)26)7-13(10)12-6-14(17(21)22-8-12)18-24-11(2)25-29-18/h5-8,23,26H,9H2,1-4H3,(H2,21,22)
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Novartis AG

US Patent


Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295207
PNG
((R)-3-(6-Amino-5-(3-methyl-1,2,4-oxadiazol-5-yl)py...)
Show SMILES Cc1noc(n1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NC[C@H]1CCOC1
Show InChI InChI=1S/C20H23N5O4S/c1-12-3-4-16(30(26,27)23-9-14-5-6-28-11-14)8-17(12)15-7-18(19(21)22-10-15)20-24-13(2)25-29-20/h3-4,7-8,10,14,23H,5-6,9,11H2,1-2H3,(H2,21,22)/t14-/m1/s1
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Novartis AG

US Patent


Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM295208
PNG
((S)-3-(6-Amino-5-(3-methyl-1,2,4-oxadiazol-5-yl)py...)
Show SMILES Cc1noc(n1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NC[C@@H]1CCOC1
Show InChI InChI=1S/C20H23N5O4S/c1-12-3-4-16(30(26,27)23-9-14-5-6-28-11-14)8-17(12)15-7-18(19(21)22-10-15)20-24-13(2)25-29-20/h3-4,7-8,10,14,23H,5-6,9,11H2,1-2H3,(H2,21,22)/t14-/m0/s1
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Novartis AG

US Patent


Assay Description
The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...


US Patent US10112926 (2018)

More data for this
Ligand-Target Pair
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