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Found 805 hits Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 3-kinase regulatory subunit beta'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288965
PNG
(US10092563, Compound 102)
Show SMILES Nc1ncnc(N[C@@H](C2CC2)c2nc3cccc(Cl)c3c(=O)n2N2CCNCC2)c1C#N
Show InChI InChI=1S/C21H22ClN9O/c22-14-2-1-3-15-16(14)21(32)31(30-8-6-25-7-9-30)20(28-15)17(12-4-5-12)29-19-13(10-23)18(24)26-11-27-19/h1-3,11-12,17,25H,4-9H2,(H3,24,26,27,29)/t17-/m0/s1
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n/an/a 5.70E+4n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288966
PNG
(US10092563, Compound 103)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1C1CCN(CC(F)(F)F)CC1
Show InChI InChI=1S/C22H22ClF3N8O/c1-12(31-19-14(9-27)18(28)29-11-30-19)20-32-16-4-2-3-15(23)17(16)21(35)34(20)13-5-7-33(8-6-13)10-22(24,25)26/h2-4,11-13H,5-8,10H2,1H3,(H3,28,29,30,31)/t12-/m0/s1
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n/an/a 2.20E+6n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288967
PNG
(US10092563, Compound 104)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1Cl)c1nc2cccc(Cl)c2c(=O)n1C1CCN(CC(F)(F)F)CC1
Show InChI InChI=1S/C21H23Cl2F3N8O/c1-10(29-17-15(23)16(27)31-20(28)32-17)18-30-13-4-2-3-12(22)14(13)19(35)34(18)11-5-7-33(8-6-11)9-21(24,25)26/h2-4,10-11H,5-9H2,1H3,(H5,27,28,29,31,32)/t10-/m0/s1
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n/an/a 1.00E+7n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288968
PNG
(US10092563, Compound 105)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1C1CCN(CC(F)F)CC1
Show InChI InChI=1S/C22H23ClF2N8O/c1-12(30-20-14(9-26)19(27)28-11-29-20)21-31-16-4-2-3-15(23)18(16)22(34)33(21)13-5-7-32(8-6-13)10-17(24)25/h2-4,11-13,17H,5-8,10H2,1H3,(H3,27,28,29,30)/t12-/m0/s1
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n/an/a 1.90E+6n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288969
PNG
(US10092563, Compound 106)
Show SMILES C[C@H](Nc1nc(N)nc(C)c1C#N)c1nc2cccc(Cl)c2c(=O)n1C1CCN(CC(F)(F)F)CC1
Show InChI InChI=1S/C23H24ClF3N8O/c1-12-15(10-28)19(33-22(29)31-12)30-13(2)20-32-17-5-3-4-16(24)18(17)21(36)35(20)14-6-8-34(9-7-14)11-23(25,26)27/h3-5,13-14H,6-9,11H2,1-2H3,(H3,29,30,31,33)/t13-/m0/s1
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n/an/a 2.60E+5n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288970
PNG
(US10092563, Compound 107)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1N1CCN(CC(F)(F)F)CC1
Show InChI InChI=1S/C21H22ClF3N10O/c1-11(29-17-12(9-26)16(27)31-20(28)32-17)18-30-14-4-2-3-13(22)15(14)19(36)35(18)34-7-5-33(6-8-34)10-21(23,24)25/h2-4,11H,5-8,10H2,1H3,(H5,27,28,29,31,32)/t11-/m0/s1
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n/an/a 5.20E+5n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288971
PNG
(US10092563, Compound 108)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1Cl)c1nc2cccc(Cl)c2c(=O)n1N1CCN(CC(F)(F)F)CC1
Show InChI InChI=1S/C20H22Cl2F3N9O/c1-10(28-16-14(22)15(26)30-19(27)31-16)17-29-12-4-2-3-11(21)13(12)18(35)34(17)33-7-5-32(6-8-33)9-20(23,24)25/h2-4,10H,5-9H2,1H3,(H5,26,27,28,30,31)/t10-/m0/s1
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n/an/a 6.10E+6n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288972
PNG
(US10092563, Compound 109)
Show SMILES C[C@H](Nc1nc(N)nc(C)c1C#N)c1nc2cccc(Cl)c2c(=O)n1N1CCN(CC(F)(F)F)CC1
Show InChI InChI=1S/C22H23ClF3N9O/c1-12-14(10-27)18(32-21(28)30-12)29-13(2)19-31-16-5-3-4-15(23)17(16)20(36)35(19)34-8-6-33(7-9-34)11-22(24,25)26/h3-5,13H,6-9,11H2,1-2H3,(H3,28,29,30,32)/t13-/m0/s1
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n/an/a 2.90E+5n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288902
PNG
(US10092563, Compound 37)
Show SMILES C[C@H](Nc1ncnc(N)c1Cl)c1nc2cccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C18H20Cl2N8O/c1-10(25-16-14(20)15(21)23-9-24-16)17-26-12-4-2-3-11(19)13(12)18(29)28(17)27-7-5-22-6-8-27/h2-4,9-10,22H,5-8H2,1H3,(H3,21,23,24,25)/t10-/m0/s1
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n/an/a 3.90E+4n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288903
PNG
(US10092563, Compound 38)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1C1CCNCC1(F)F
Show InChI InChI=1S/C20H20ClF2N9O/c1-9(28-16-10(7-24)15(25)30-19(26)31-16)17-29-12-4-2-3-11(21)14(12)18(33)32(17)13-5-6-27-8-20(13,22)23/h2-4,9,13,27H,5-6,8H2,1H3,(H5,25,26,28,30,31)/t9-,13?/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288904
PNG
(US10092563, Compound 39)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2c(F)ccc(F)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C19H20F2N10O/c1-9(26-16-10(8-22)15(23)28-19(24)29-16)17-27-14-12(21)3-2-11(20)13(14)18(32)31(17)30-6-4-25-5-7-30/h2-3,9,25H,4-7H2,1H3,(H5,23,24,26,28,29)/t9-/m0/s1
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n/an/a 4.00E+3n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288905
PNG
(US10092563, Compound 40)
Show SMILES C[C@H](Nc1ncnn2ccnc12)c1nc2c(F)ccc(F)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C19H19F2N9O/c1-11(26-16-18-23-6-9-29(18)25-10-24-16)17-27-15-13(21)3-2-12(20)14(15)19(31)30(17)28-7-4-22-5-8-28/h2-3,6,9-11,22H,4-5,7-8H2,1H3,(H,24,25,26)/t11-/m0/s1
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n/an/a 2.00E+5n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288906
PNG
(US10092563, Compound 41)
Show SMILES Fc1ccc(F)c2c1nc([C@@H](Nc1ncnn3ccnc13)C1CC1)n(N1CCNCC1)c2=O
Show InChI InChI=1S/C21H21F2N9O/c22-13-3-4-14(23)17-15(13)21(33)32(30-8-5-24-6-9-30)19(29-17)16(12-1-2-12)28-18-20-25-7-10-31(20)27-11-26-18/h3-4,7,10-12,16,24H,1-2,5-6,8-9H2,(H,26,27,28)/t16-/m0/s1
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n/an/a 2.10E+5n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288907
PNG
(US10092563, Compound 42)
Show SMILES CC[C@H](Nc1ncnn2ccnc12)c1nc2cccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C20H22ClN9O/c1-2-14(26-17-19-23-8-11-29(19)25-12-24-17)18-27-15-5-3-4-13(21)16(15)20(31)30(18)28-9-6-22-7-10-28/h3-5,8,11-12,14,22H,2,6-7,9-10H2,1H3,(H,24,25,26)/t14-/m0/s1
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n/an/a 4.50E+4n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288908
PNG
(US10092563, Compound 43)
Show SMILES Clc1cccc2nc([C@@H](Nc3ncnn4ccnc34)C3CC3)n(N3CCNCC3)c(=O)c12
Show InChI InChI=1S/C21H22ClN9O/c22-14-2-1-3-15-16(14)21(32)31(29-9-6-23-7-10-29)19(27-15)17(13-4-5-13)28-18-20-24-8-11-30(20)26-12-25-18/h1-3,8,11-13,17,23H,4-7,9-10H2,(H,25,26,28)/t17-/m0/s1
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n/an/a 3.00E+4n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288909
PNG
(US10092563, Compound 44)
Show SMILES CC[C@H](Nc1nc(N)nc(C)c1C#N)c1nc2cccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C21H24ClN9O/c1-3-15(27-18-13(11-23)12(2)26-21(24)29-18)19-28-16-6-4-5-14(22)17(16)20(32)31(19)30-9-7-25-8-10-30/h4-6,15,25H,3,7-10H2,1-2H3,(H3,24,26,27,29)/t15-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288910
PNG
(US10092563, Compound 46)
Show SMILES Cc1nc(N)nc(N[C@@H](C2CC2)c2nc3cccc(Cl)c3c(=O)n2N2CCNCC2)c1C#N
Show InChI InChI=1S/C22H24ClN9O/c1-12-14(11-24)19(30-22(25)27-12)29-18(13-5-6-13)20-28-16-4-2-3-15(23)17(16)21(33)32(20)31-9-7-26-8-10-31/h2-4,13,18,26H,5-10H2,1H3,(H3,25,27,29,30)/t18-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288911
PNG
(US10092563, Compound 47)
Show SMILES Fc1ccc(Cl)c2c1nc([C@@H](Nc1ncnn3ccnc13)C1CC1)n(N1CCNCC1)c2=O
Show InChI InChI=1S/C21H21ClFN9O/c22-13-3-4-14(23)17-15(13)21(33)32(30-8-5-24-6-9-30)19(29-17)16(12-1-2-12)28-18-20-25-7-10-31(20)27-11-26-18/h3-4,7,10-12,16,24H,1-2,5-6,8-9H2,(H,26,27,28)/t16-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288912
PNG
(US10092563, Compound 48)
Show SMILES Nc1nc(N)c(C#N)c(N[C@@H](C2CC2)c2nc3c(F)ccc(Cl)c3c(=O)n2N2CCNCC2)n1
Show InChI InChI=1S/C21H22ClFN10O/c22-12-3-4-13(23)16-14(12)20(34)33(32-7-5-27-6-8-32)19(29-16)15(10-1-2-10)28-18-11(9-24)17(25)30-21(26)31-18/h3-4,10,15,27H,1-2,5-8H2,(H5,25,26,28,30,31)/t15-/m0/s1
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n/an/a 3.00E+3n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288913
PNG
(US10092563, Compound 49)
Show SMILES C[C@H](Nc1ncnc2scnc12)c1nc2c(Cl)ccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C19H18Cl2N8OS/c1-10(26-16-15-18(24-8-23-16)31-9-25-15)17-27-14-12(21)3-2-11(20)13(14)19(30)29(17)28-6-4-22-5-7-28/h2-3,8-10,22H,4-7H2,1H3,(H,23,24,26)/t10-/m0/s1
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n/an/a 1.90E+4n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288914
PNG
(US10092563, Compound 50)
Show SMILES C[C@H](Nc1ncnc2scnc12)c1nc2c(F)ccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C19H18ClFN8OS/c1-10(26-16-15-18(24-8-23-16)31-9-25-15)17-27-14-12(21)3-2-11(20)13(14)19(30)29(17)28-6-4-22-5-7-28/h2-3,8-10,22H,4-7H2,1H3,(H,23,24,26)/t10-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288915
PNG
(US10092563, Compound 52)
Show SMILES C[C@H](Nc1ncnc2ccc(Cl)nc12)c1nc2c(Cl)ccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C21H19Cl3N8O/c1-11(28-19-18-14(26-10-27-19)4-5-15(24)29-18)20-30-17-13(23)3-2-12(22)16(17)21(33)32(20)31-8-6-25-7-9-31/h2-5,10-11,25H,6-9H2,1H3,(H,26,27,28)/t11-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288916
PNG
(US10092563, Compound 53)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2c(Cl)ccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C19H20Cl2N10O/c1-9(26-16-10(8-22)15(23)28-19(24)29-16)17-27-14-12(21)3-2-11(20)13(14)18(32)31(17)30-6-4-25-5-7-30/h2-3,9,25H,4-7H2,1H3,(H5,23,24,26,28,29)/t9-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288916
PNG
(US10092563, Compound 53)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2c(Cl)ccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C19H20Cl2N10O/c1-9(26-16-10(8-22)15(23)28-19(24)29-16)17-27-14-12(21)3-2-11(20)13(14)18(32)31(17)30-6-4-25-5-7-30/h2-3,9,25H,4-7H2,1H3,(H5,23,24,26,28,29)/t9-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288917
PNG
(US10092563, Compound 54)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2c(F)ccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C19H20ClFN10O/c1-9(26-16-10(8-22)15(23)28-19(24)29-16)17-27-14-12(21)3-2-11(20)13(14)18(32)31(17)30-6-4-25-5-7-30/h2-3,9,25H,4-7H2,1H3,(H5,23,24,26,28,29)/t9-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288918
PNG
(US10092563, Compound 55)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C19H20ClN9O/c1-11(26-17-12(9-21)16(22)24-10-25-17)18-27-14-4-2-3-13(20)15(14)19(30)29(18)28-7-5-23-6-8-28/h2-4,10-11,23H,5-8H2,1H3,(H3,22,24,25,26)/t11-/m0/s1
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n/an/a 1.40E+4n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288919
PNG
(US10092563, Compound 56)
Show SMILES C[C@H](NC(=O)c1nccnc1N)c1nc2cccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C19H21ClN8O2/c1-11(25-18(29)15-16(21)24-6-5-23-15)17-26-13-4-2-3-12(20)14(13)19(30)28(17)27-9-7-22-8-10-27/h2-6,11,22H,7-10H2,1H3,(H2,21,24)(H,25,29)/t11-/m0/s1
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n/an/a 2.10E+4n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288920
PNG
(US10092563, Compound 57)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C19H21ClN10O/c1-10(25-16-11(9-21)15(22)27-19(23)28-16)17-26-13-4-2-3-12(20)14(13)18(31)30(17)29-7-5-24-6-8-29/h2-4,10,24H,5-8H2,1H3,(H5,22,23,25,27,28)/t10-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM208901
PNG
(US10092563, Compound 58 | US9266878, 127a)
Show SMILES C[C@H](Nc1ncnc(N)c1C#Cc1ccc(F)cn1)c1nc2cccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C25H23ClFN9O/c1-15(33-23-18(22(28)31-14-32-23)8-7-17-6-5-16(27)13-30-17)24-34-20-4-2-3-19(26)21(20)25(37)36(24)35-11-9-29-10-12-35/h2-6,13-15,29H,9-12H2,1H3,(H3,28,31,32,33)/t15-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288922
PNG
(US10092563, Compound 59)
Show SMILES C[C@H](NC(=O)c1nc(C)c(C)nc1N)c1nc2cccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C21H25ClN8O2/c1-11-12(2)26-18(23)17(25-11)20(31)27-13(3)19-28-15-6-4-5-14(22)16(15)21(32)30(19)29-9-7-24-8-10-29/h4-6,13,24H,7-10H2,1-3H3,(H2,23,26)(H,27,31)/t13-/m0/s1
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n/an/a 7.30E+4n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288923
PNG
(US10092563, Compound 60)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nc2cccc(C)c2c(=O)n1C1CCNCC1
Show InChI InChI=1S/C21H24N8O/c1-12-4-3-5-16-17(12)21(30)29(14-6-8-24-9-7-14)20(28-16)13(2)27-19-15(10-22)18(23)25-11-26-19/h3-5,11,13-14,24H,6-9H2,1-2H3,(H3,23,25,26,27)/t13-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288924
PNG
(US10092563, Compound 61)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1N1CCNC(C1)C(F)(F)F
Show InChI InChI=1S/C20H20ClF3N10O/c1-9(29-16-10(7-25)15(26)31-19(27)32-16)17-30-12-4-2-3-11(21)14(12)18(35)34(17)33-6-5-28-13(8-33)20(22,23)24/h2-4,9,13,28H,5-6,8H2,1H3,(H5,26,27,29,31,32)/t9-,13?/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288925
PNG
(US10092563, Compound 62)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1N1CCNC(C1)C(F)(F)F
Show InChI InChI=1S/C20H19ClF3N9O/c1-10(30-17-11(7-25)16(26)28-9-29-17)18-31-13-4-2-3-12(21)15(13)19(34)33(18)32-6-5-27-14(8-32)20(22,23)24/h2-4,9-10,14,27H,5-6,8H2,1H3,(H3,26,28,29,30)/t10-,14?/m0/s1
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n/an/a 8.20E+5n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288926
PNG
(US10092563, Compound 63)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1N1CCNC2(CC2)C1
Show InChI InChI=1S/C21H22ClN9O/c1-12(28-18-13(9-23)17(24)25-11-26-18)19-29-15-4-2-3-14(22)16(15)20(32)31(19)30-8-7-27-21(10-30)5-6-21/h2-4,11-12,27H,5-8,10H2,1H3,(H3,24,25,26,28)/t12-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288927
PNG
(US10092563, Compound 64)
Show SMILES C[C@H](Nc1ncnn2ccnc12)c1nc2cccc(Cl)c2c(=O)n1N1CCCNCC1
Show InChI InChI=1S/C20H22ClN9O/c1-13(26-17-19-23-8-11-29(19)25-12-24-17)18-27-15-5-2-4-14(21)16(15)20(31)30(18)28-9-3-6-22-7-10-28/h2,4-5,8,11-13,22H,3,6-7,9-10H2,1H3,(H,24,25,26)/t13-/m0/s1
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n/an/a 9.40E+4n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288928
PNG
(US10092563, Compound 65)
Show SMILES C[C@H](Nc1ncnn2ccnc12)c1nc2cccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C19H20ClN9O/c1-12(25-16-18-22-7-10-28(18)24-11-23-16)17-26-14-4-2-3-13(20)15(14)19(30)29(17)27-8-5-21-6-9-27/h2-4,7,10-12,21H,5-6,8-9H2,1H3,(H,23,24,25)/t12-/m0/s1
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n/an/a 4.20E+4n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288929
PNG
(US10092563, Compound 66 | US10092563, Compound 67)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1N1CCCNCC1
Show InChI InChI=1S/C20H22ClN9O/c1-12(27-18-13(10-22)17(23)25-11-26-18)19-28-15-5-2-4-14(21)16(15)20(31)30(19)29-8-3-6-24-7-9-29/h2,4-5,11-12,24H,3,6-9H2,1H3,(H3,23,25,26,27)/t12-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288929
PNG
(US10092563, Compound 66 | US10092563, Compound 67)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1N1CCCNCC1
Show InChI InChI=1S/C20H22ClN9O/c1-12(27-18-13(10-22)17(23)25-11-26-18)19-28-15-5-2-4-14(21)16(15)20(31)30(19)29-8-3-6-24-7-9-29/h2,4-5,11-12,24H,3,6-9H2,1H3,(H3,23,25,26,27)/t12-/m0/s1
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n/an/a 2.20E+4n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288931
PNG
(US10092563, Compound 68)
Show SMILES CC[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C20H23ClN10O/c1-2-13(26-17-11(10-22)16(23)28-20(24)29-17)18-27-14-5-3-4-12(21)15(14)19(32)31(18)30-8-6-25-7-9-30/h3-5,13,25H,2,6-9H2,1H3,(H5,23,24,26,28,29)/t13-/m0/s1
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n/an/a 1.00E+3n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288932
PNG
(US10092563, Compound 69)
Show SMILES C[C@H](Nc1ncnc2[nH]cc(Br)c12)c1nc2cccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C20H20BrClN8O/c1-11(27-18-15-12(21)9-24-17(15)25-10-26-18)19-28-14-4-2-3-13(22)16(14)20(31)30(19)29-7-5-23-6-8-29/h2-4,9-11,23H,5-8H2,1H3,(H2,24,25,26,27)/t11-/m0/s1
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n/an/a 3.00E+3n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288933
PNG
(US10092563, Compound 70)
Show SMILES C[C@H](Nc1ncnc2scnc12)c1nc2cccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C19H19ClN8OS/c1-11(25-16-15-18(23-9-22-16)30-10-24-15)17-26-13-4-2-3-12(20)14(13)19(29)28(17)27-7-5-21-6-8-27/h2-4,9-11,21H,5-8H2,1H3,(H,22,23,25)/t11-/m0/s1
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n/an/a 1.40E+4n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288934
PNG
(US10092563, Compound 71)
Show SMILES C[C@H](Nc1ncnc2ccc(Cl)nc12)c1nc2cccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C21H20Cl2N8O/c1-12(27-19-18-15(25-11-26-19)5-6-16(23)29-18)20-28-14-4-2-3-13(22)17(14)21(32)31(20)30-9-7-24-8-10-30/h2-6,11-12,24H,7-10H2,1H3,(H,25,26,27)/t12-/m0/s1
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n/an/a 3.00E+3n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288935
PNG
(US10092563, Compound 72)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1Cl)c1nc2cccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C18H21Cl2N9O/c1-9(24-15-13(20)14(21)26-18(22)27-15)16-25-11-4-2-3-10(19)12(11)17(30)29(16)28-7-5-23-6-8-28/h2-4,9,23H,5-8H2,1H3,(H5,21,22,24,26,27)/t9-/m0/s1
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n/an/a 2.80E+4n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288936
PNG
(US10092563, Compound 73)
Show SMILES C[C@H](Nc1ncnc2cccnc12)c1nc2cccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C21H21ClN8O/c1-13(27-19-18-16(25-12-26-19)6-3-7-24-18)20-28-15-5-2-4-14(22)17(15)21(31)30(20)29-10-8-23-9-11-29/h2-7,12-13,23H,8-11H2,1H3,(H,25,26,27)/t13-/m0/s1
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n/an/a 1.90E+4n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288937
PNG
(US10092563, Compound 74)
Show SMILES CC(C)C[C@H](Nc1ncnc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C22H26ClN9O/c1-13(2)10-17(29-20-14(11-24)19(25)27-12-28-20)21-30-16-5-3-4-15(23)18(16)22(33)32(21)31-8-6-26-7-9-31/h3-5,12-13,17,26H,6-10H2,1-2H3,(H3,25,27,28,29)/t17-/m0/s1
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n/an/a 5.70E+5n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288938
PNG
(US10092563, Compound 75)
Show SMILES CC(C)C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C22H27ClN10O/c1-12(2)10-16(28-19-13(11-24)18(25)30-22(26)31-19)20-29-15-5-3-4-14(23)17(15)21(34)33(20)32-8-6-27-7-9-32/h3-5,12,16,27H,6-10H2,1-2H3,(H5,25,26,28,30,31)/t16-/m0/s1
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n/an/a 3.70E+4n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288939
PNG
(US10092563, Compound 76)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nc2c(Cl)ccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C19H19Cl2N9O/c1-10(27-17-11(8-22)16(23)25-9-26-17)18-28-15-13(21)3-2-12(20)14(15)19(31)30(18)29-6-4-24-5-7-29/h2-3,9-10,24H,4-7H2,1H3,(H3,23,25,26,27)/t10-/m0/s1
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n/an/a 2.50E+4n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288940
PNG
(US10092563, Compound 77)
Show SMILES Nc1nc(N)c(C#N)c(N[C@@H](C2CC2)c2nc3cccc(Cl)c3c(=O)n2N2CCNCC2)n1
Show InChI InChI=1S/C21H23ClN10O/c22-13-2-1-3-14-15(13)20(33)32(31-8-6-26-7-9-31)19(27-14)16(11-4-5-11)28-18-12(10-23)17(24)29-21(25)30-18/h1-3,11,16,26H,4-9H2,(H5,24,25,28,29,30)/t16-/m0/s1
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n/an/a 1.00E+3n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288941
PNG
(US10092563, Compound 78)
Show SMILES Clc1cccc2nc([C@@H](Nc3ncnc4scnc34)C3CC3)n(N3CCNCC3)c(=O)c12
Show InChI InChI=1S/C21H21ClN8OS/c22-13-2-1-3-14-15(13)21(31)30(29-8-6-23-7-9-29)19(27-14)16(12-4-5-12)28-18-17-20(25-10-24-18)32-11-26-17/h1-3,10-12,16,23H,4-9H2,(H,24,25,28)/t16-/m0/s1
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n/an/a 1.80E+4n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288942
PNG
(US10092563, Compound 79)
Show SMILES CC[C@H](Nc1ncnc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C20H22ClN9O/c1-2-14(27-18-12(10-22)17(23)25-11-26-18)19-28-15-5-3-4-13(21)16(15)20(31)30(19)29-8-6-24-7-9-29/h3-5,11,14,24H,2,6-9H2,1H3,(H3,23,25,26,27)/t14-/m0/s1
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n/an/a 7.80E+4n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
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