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Compile Data Set for Download or QSAR

Found 8022 hits Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113568
PNG
(US8633204, 315)
Show SMILES COc1ncc(cc1F)-c1cc2c(C)nc(N)nc2n([C@H]2C[C@@H](C2)OCCO)c1=O
Show InChI InChI=1S/C20H22FN5O4/c1-10-14-8-15(11-5-16(21)18(29-2)23-9-11)19(28)26(17(14)25-20(22)24-10)12-6-13(7-12)30-4-3-27/h5,8-9,12-13,27H,3-4,6-7H2,1-2H3,(H2,22,24,25)/t12-,13-
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n/an/a 3.11n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113465
PNG
(US8633204, 175)
Show SMILES COc1ccc(cn1)-c1cc2c(C)nc(N)nc2n(C2CCC(=O)CC2)c1=O
Show InChI InChI=1S/C20H21N5O3/c1-11-15-9-16(12-3-8-17(28-2)22-10-12)19(27)25(18(15)24-20(21)23-11)13-4-6-14(26)7-5-13/h3,8-10,13H,4-7H2,1-2H3,(H2,21,23,24)
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n/an/a 4.30n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113467
PNG
(US8633204, 177)
Show SMILES COc1ncc(cc1F)-c1cc2c(C)nc(N)nc2n([C@@H]2CC[C@H](O)CC2)c1=O
Show InChI InChI=1S/C20H22FN5O3/c1-10-14-8-15(11-7-16(21)18(29-2)23-9-11)19(28)26(17(14)25-20(22)24-10)12-3-5-13(27)6-4-12/h7-9,12-13,27H,3-6H2,1-2H3,(H2,22,24,25)/t12-,13+
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n/an/a 2.40n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113470
PNG
(US8633204, 181)
Show SMILES CN(C)c1ccc(cn1)-c1cc2c(C)nc(N)nc2n([C@@H]2CC[C@H](O)CC2)c1=O
Show InChI InChI=1S/C21H26N6O2/c1-12-16-10-17(13-4-9-18(23-11-13)26(2)3)20(29)27(19(16)25-21(22)24-12)14-5-7-15(28)8-6-14/h4,9-11,14-15,28H,5-8H2,1-3H3,(H2,22,24,25)/t14-,15+
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n/an/a 12n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113472
PNG
(US8633204, 183)
Show SMILES CO[C@H]1CC[C@@H](CC1)n1c2nc(N)nc(C)c2cc(-c2cn[nH]c2)c1=O
Show InChI InChI=1S/C18H22N6O2/c1-10-14-7-15(11-8-20-21-9-11)17(25)24(16(14)23-18(19)22-10)12-3-5-13(26-2)6-4-12/h7-9,12-13H,3-6H2,1-2H3,(H,20,21)(H2,19,22,23)/t12-,13-
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n/an/a 9n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113474
PNG
(US8633204, 185)
Show SMILES Cc1nc(N)nc2n(C3CCC(C)(O)CC3)c(=O)c(cc12)-c1cn[nH]c1
Show InChI InChI=1S/C18H22N6O2/c1-10-13-7-14(11-8-20-21-9-11)16(25)24(15(13)23-17(19)22-10)12-3-5-18(2,26)6-4-12/h7-9,12,26H,3-6H2,1-2H3,(H,20,21)(H2,19,22,23)
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n/an/a 18n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113476
PNG
(US8633204, 188)
Show SMILES CC(C)Oc1ccc(cn1)-c1cc2c(C)nc(N)nc2n([C@H]2CC[C@H](O)CC2)c1=O
Show InChI InChI=1S/C22H27N5O3/c1-12(2)30-19-9-4-14(11-24-19)18-10-17-13(3)25-22(23)26-20(17)27(21(18)29)15-5-7-16(28)8-6-15/h4,9-12,15-16,28H,5-8H2,1-3H3,(H2,23,25,26)/t15-,16-
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n/an/a 9.40n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113478
PNG
(US8633204, 190)
Show SMILES Cc1nc(N)nc2n([C@H]3CC[C@H](O)CC3)c(=O)c(cc12)-c1ccc(nc1)C#N
Show InChI InChI=1S/C20H20N6O2/c1-11-16-8-17(12-2-3-13(9-21)23-10-12)19(28)26(18(16)25-20(22)24-11)14-4-6-15(27)7-5-14/h2-3,8,10,14-15,27H,4-7H2,1H3,(H2,22,24,25)/t14-,15-
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n/an/a 470n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113480
PNG
(US8633204, 194)
Show SMILES CN(C)c1ccc(cn1)-c1cc2c(C)nc(N)nc2n([C@H]2CC[C@H](O)CC2)c1=O
Show InChI InChI=1S/C21H26N6O2/c1-12-16-10-17(13-4-9-18(23-11-13)26(2)3)20(29)27(19(16)25-21(22)24-12)14-5-7-15(28)8-6-14/h4,9-11,14-15,28H,5-8H2,1-3H3,(H2,22,24,25)/t14-,15-
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n/an/a 5.90n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113481
PNG
(US8633204, 197)
Show SMILES Cc1nc(N)nc2n(CC(F)(F)F)c(=O)c(cc12)-c1cn[nH]c1
Show InChI InChI=1S/C13H11F3N6O/c1-6-8-2-9(7-3-18-19-4-7)11(23)22(5-13(14,15)16)10(8)21-12(17)20-6/h2-4H,5H2,1H3,(H,18,19)(H2,17,20,21)
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n/an/a 188n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113483
PNG
(US8633204, 199)
Show SMILES Cc1nc(N)nc2n(C3CCOCC3)c(=O)c(cc12)-c1cn[nH]c1
Show InChI InChI=1S/C16H18N6O2/c1-9-12-6-13(10-7-18-19-8-10)15(23)22(11-2-4-24-5-3-11)14(12)21-16(17)20-9/h6-8,11H,2-5H2,1H3,(H,18,19)(H2,17,20,21)
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n/an/a 18.5n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113485
PNG
(US8633204, 201)
Show SMILES Cc1nc(N)nc2n(C3CCOCC3)c(=O)c(cc12)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C20H20N6O2/c1-11-15-9-16(13-8-12-2-5-22-17(12)23-10-13)19(27)26(14-3-6-28-7-4-14)18(15)25-20(21)24-11/h2,5,8-10,14H,3-4,6-7H2,1H3,(H,22,23)(H2,21,24,25)
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n/an/a 3.70n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113487
PNG
(US8633204, 203)
Show SMILES Cc1nc(N)nc2n(C3CCOC3)c(=O)c(cc12)-c1cn[nH]c1
Show InChI InChI=1S/C15H16N6O2/c1-8-11-4-12(9-5-17-18-6-9)14(22)21(10-2-3-23-7-10)13(11)20-15(16)19-8/h4-6,10H,2-3,7H2,1H3,(H,17,18)(H2,16,19,20)
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n/an/a 20n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50387588
PNG
(CHEMBL2057728 | US8633204, 205)
Show SMILES Cc1nc(N)nc2n(C3CCC3)c(=O)c(cc12)-c1cn[nH]c1
Show InChI InChI=1S/C15H16N6O/c1-8-11-5-12(9-6-17-18-7-9)14(22)21(10-3-2-4-10)13(11)20-15(16)19-8/h5-7,10H,2-4H2,1H3,(H,17,18)(H2,16,19,20)
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n/an/a 15n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50387586
PNG
(CHEMBL2057731 | US8633204, 208)
Show SMILES CC(C)n1c2nc(N)nc(C)c2cc(-c2cn[nH]c2)c1=O
Show InChI InChI=1S/C14H16N6O/c1-7(2)20-12-10(8(3)18-14(15)19-12)4-11(13(20)21)9-5-16-17-6-9/h4-7H,1-3H3,(H,16,17)(H2,15,18,19)
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n/an/a 29.4n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113490
PNG
(US8633204, 210)
Show SMILES CC(C)n1c2nc(N)nc(C)c2cc(-c2cnc3[nH]ccc3c2)c1=O
Show InChI InChI=1S/C18H18N6O/c1-9(2)24-16-13(10(3)22-18(19)23-16)7-14(17(24)25)12-6-11-4-5-20-15(11)21-8-12/h4-9H,1-3H3,(H,20,21)(H2,19,22,23)
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n/an/a 2.30n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113447
PNG
(US8633204, 157)
Show SMILES Cc1nc(N)nc2n([C@H]3CC[C@H](O)CC3)c(=O)c(Br)cc12
Show InChI InChI=1S/C14H17BrN4O2/c1-7-10-6-11(15)13(21)19(12(10)18-14(16)17-7)8-2-4-9(20)5-3-8/h6,8-9,20H,2-5H2,1H3,(H2,16,17,18)/t8-,9-
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n/an/a 44n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113491
PNG
(US8633204, 213)
Show SMILES Cc1nc(N)nc2n(C3CC3)c(=O)c(cc12)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C18H16N6O/c1-9-13-7-14(11-6-10-4-5-20-15(10)21-8-11)17(25)24(12-2-3-12)16(13)23-18(19)22-9/h4-8,12H,2-3H2,1H3,(H,20,21)(H2,19,22,23)
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n/an/a 17n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113493
PNG
(US8633204, 215)
Show SMILES CNc1nc(C)c2cc(-c3cn[nH]c3)c(=O)n(CC3CCOC3)c2n1
Show InChI InChI=1S/C17H20N6O2/c1-10-13-5-14(12-6-19-20-7-12)16(24)23(8-11-3-4-25-9-11)15(13)22-17(18-2)21-10/h5-7,11H,3-4,8-9H2,1-2H3,(H,19,20)(H,18,21,22)
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n/an/a 6n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113495
PNG
(US8633204, 217)
Show SMILES CNc1nc(C)c2cc(-c3cnc4[nH]ccc4c3)c(=O)n(CC3CCOC3)c2n1
Show InChI InChI=1S/C21H22N6O2/c1-12-16-8-17(15-7-14-3-5-23-18(14)24-9-15)20(28)27(10-13-4-6-29-11-13)19(16)26-21(22-2)25-12/h3,5,7-9,13H,4,6,10-11H2,1-2H3,(H,23,24)(H,22,25,26)
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Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113498
PNG
(US8633204, 220)
Show SMILES COc1ccc(cn1)-c1cc2c(C)nc(N)nc2n(CC2CCOC2)c1=O
Show InChI InChI=1S/C19H21N5O3/c1-11-14-7-15(13-3-4-16(26-2)21-8-13)18(25)24(9-12-5-6-27-10-12)17(14)23-19(20)22-11/h3-4,7-8,12H,5-6,9-10H2,1-2H3,(H2,20,22,23)
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n/an/a 7.70n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113500
PNG
(US8633204, 222)
Show SMILES Cc1nc(N)nc2n(CC3CCCO3)c(=O)c(Br)cc12
Show InChI InChI=1S/C13H15BrN4O2/c1-7-9-5-10(14)12(19)18(6-8-3-2-4-20-8)11(9)17-13(15)16-7/h5,8H,2-4,6H2,1H3,(H2,15,16,17)
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n/an/a 100n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113502
PNG
(US8633204, 224)
Show SMILES COc1ccc(cn1)-c1cc2c(C)nc(N)nc2n(CC2CCCO2)c1=O
Show InChI InChI=1S/C19H21N5O3/c1-11-14-8-15(12-5-6-16(26-2)21-9-12)18(25)24(10-13-4-3-7-27-13)17(14)23-19(20)22-11/h5-6,8-9,13H,3-4,7,10H2,1-2H3,(H2,20,22,23)
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n/an/a 21n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113504
PNG
(US8633204, 226)
Show SMILES Cc1nc(N)nc2n(C3CN(C3)C(=O)OC(C)(C)C)c(=O)c(cc12)-c1cn[nH]c1
Show InChI InChI=1S/C19H23N7O3/c1-10-13-5-14(11-6-21-22-7-11)16(27)26(15(13)24-17(20)23-10)12-8-25(9-12)18(28)29-19(2,3)4/h5-7,12H,8-9H2,1-4H3,(H,21,22)(H2,20,23,24)
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n/an/a 120n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113506
PNG
(US8633204, 228)
Show SMILES Cc1nc(N)nc2n(C3CN(C3)C(=O)OC(C)(C)C)c(=O)c(cc12)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C23H25N7O3/c1-12-16-8-17(14-7-13-5-6-25-18(13)26-9-14)20(31)30(19(16)28-21(24)27-12)15-10-29(11-15)22(32)33-23(2,3)4/h5-9,15H,10-11H2,1-4H3,(H,25,26)(H2,24,27,28)
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n/an/a 38n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113508
PNG
(US8633204, 230)
Show SMILES Cc1nc(N)nc2n(C3CCCC3)c(=O)c(cc12)-c1cncc(N)n1
Show InChI InChI=1S/C17H19N7O/c1-9-11-6-12(13-7-20-8-14(18)22-13)16(25)24(10-4-2-3-5-10)15(11)23-17(19)21-9/h6-8,10H,2-5H2,1H3,(H2,18,22)(H2,19,21,23)
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Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113511
PNG
(US8633204, 233)
Show SMILES COc1ccc(cn1)-c1cc2c(C)nc(N)nc2n(CCC2CC2)c1=O
Show InChI InChI=1S/C19H21N5O2/c1-11-14-9-15(13-5-6-16(26-2)21-10-13)18(25)24(8-7-12-3-4-12)17(14)23-19(20)22-11/h5-6,9-10,12H,3-4,7-8H2,1-2H3,(H2,20,22,23)
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Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113513
PNG
(US8633204, 235)
Show SMILES Cc1nc(N)nc2n(C3CCCC3)c(=O)c(cc12)-c1cnn(C)c1
Show InChI InChI=1S/C17H20N6O/c1-10-13-7-14(11-8-19-22(2)9-11)16(24)23(12-5-3-4-6-12)15(13)21-17(18)20-10/h7-9,12H,3-6H2,1-2H3,(H2,18,20,21)
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n/an/a 32n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113515
PNG
(US8633204, 237)
Show SMILES Cc1nc(N)nc2n(C3CCCC3)c(=O)c(cc12)-c1cnn(CC(F)F)c1
Show InChI InChI=1S/C18H20F2N6O/c1-10-13-6-14(11-7-22-25(8-11)9-15(19)20)17(27)26(12-4-2-3-5-12)16(13)24-18(21)23-10/h6-8,12,15H,2-5,9H2,1H3,(H2,21,23,24)
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Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113517
PNG
(US8633204, 239)
Show SMILES CNc1nc(C)c2cc(-c3ccc(OC)nc3)c(=O)n(CCN)c2n1
Show InChI InChI=1S/C17H20N6O2/c1-10-12-8-13(11-4-5-14(25-3)20-9-11)16(24)23(7-6-18)15(12)22-17(19-2)21-10/h4-5,8-9H,6-7,18H2,1-3H3,(H,19,21,22)
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Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113519
PNG
(US8633204, 241)
Show SMILES COc1ccc(cn1)-c1cc2c(C)nc(N)nc2n(CC(C)C)c1=O
Show InChI InChI=1S/C18H21N5O2/c1-10(2)9-23-16-13(11(3)21-18(19)22-16)7-14(17(23)24)12-5-6-15(25-4)20-8-12/h5-8,10H,9H2,1-4H3,(H2,19,21,22)
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Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113521
PNG
(US8633204, 243)
Show SMILES COc1ccc(cn1)-c1cc2c(C)nc(N)nc2n(CC2(F)CCOCC2)c1=O
Show InChI InChI=1S/C20H22FN5O3/c1-12-14-9-15(13-3-4-16(28-2)23-10-13)18(27)26(17(14)25-19(22)24-12)11-20(21)5-7-29-8-6-20/h3-4,9-10H,5-8,11H2,1-2H3,(H2,22,24,25)
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Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113524
PNG
(US8633204, 246)
Show SMILES COc1ccc(cn1)-c1cc2c(C)nc(N)nc2n(C2CCN(C2)C(=O)OC(C)(C)C)c1=O
Show InChI InChI=1S/C23H28N6O4/c1-13-16-10-17(14-6-7-18(32-5)25-11-14)20(30)29(19(16)27-21(24)26-13)15-8-9-28(12-15)22(31)33-23(2,3)4/h6-7,10-11,15H,8-9,12H2,1-5H3,(H2,24,26,27)
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Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113526
PNG
(US8633204, 254)
Show SMILES COc1ncc(cc1F)-c1cc2c(C)nc(N)nc2n(C2CCCC2)c1=O
Show InChI InChI=1S/C19H20FN5O2/c1-10-13-8-14(11-7-15(20)17(27-2)22-9-11)18(26)25(12-5-3-4-6-12)16(13)24-19(21)23-10/h7-9,12H,3-6H2,1-2H3,(H2,21,23,24)
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Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113528
PNG
(US8633204, 256)
Show SMILES CCc1cccc(c1)-c1cc2c(C)nc(N)nc2n(C2CCCC2)c1=O
Show InChI InChI=1S/C21H24N4O/c1-3-14-7-6-8-15(11-14)18-12-17-13(2)23-21(22)24-19(17)25(20(18)26)16-9-4-5-10-16/h6-8,11-12,16H,3-5,9-10H2,1-2H3,(H2,22,23,24)
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Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113530
PNG
(US8633204, 258)
Show SMILES Cc1nc(N)nc2n(C3CCCC3)c(=O)c(cc12)-c1ccc(nc1)N1CCCC1
Show InChI InChI=1S/C22H26N6O/c1-14-17-12-18(15-8-9-19(24-13-15)27-10-4-5-11-27)21(29)28(16-6-2-3-7-16)20(17)26-22(23)25-14/h8-9,12-13,16H,2-7,10-11H2,1H3,(H2,23,25,26)
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Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113532
PNG
(US8633204, 260)
Show SMILES Cc1nc(N)nc2n(C3CCOCC3)c(=O)c(cc12)-c1cccc(CO)c1
Show InChI InChI=1S/C20H22N4O3/c1-12-16-10-17(14-4-2-3-13(9-14)11-25)19(26)24(15-5-7-27-8-6-15)18(16)23-20(21)22-12/h2-4,9-10,15,25H,5-8,11H2,1H3,(H2,21,22,23)
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Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113534
PNG
(US8633204, 262)
Show SMILES COc1ccc(cc1F)-c1cc2c(C)nc(N)nc2n(C2CCCC2)c1=O
Show InChI InChI=1S/C20H21FN4O2/c1-11-14-10-15(12-7-8-17(27-2)16(21)9-12)19(26)25(13-5-3-4-6-13)18(14)24-20(22)23-11/h7-10,13H,3-6H2,1-2H3,(H2,22,23,24)
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Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113554
PNG
(US8633204, 291)
Show SMILES Cc1nc(N)nc2n([C@H]3CC[C@@H](CC3)OCCO)c(=O)c(Br)cc12
Show InChI InChI=1S/C16H21BrN4O3/c1-9-12-8-13(17)15(23)21(14(12)20-16(18)19-9)10-2-4-11(5-3-10)24-7-6-22/h8,10-11,22H,2-7H2,1H3,(H2,18,19,20)/t10-,11-
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Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113556
PNG
(US8633204, 293)
Show SMILES COc1ncc(cn1)-c1cc2c(C)nc(N)nc2n([C@@H]2CC[C@@H](CC2)OCCO)c1=O
Show InChI InChI=1S/C21H26N6O4/c1-12-16-9-17(13-10-23-21(30-2)24-11-13)19(29)27(18(16)26-20(22)25-12)14-3-5-15(6-4-14)31-8-7-28/h9-11,14-15,28H,3-8H2,1-2H3,(H2,22,25,26)/t14-,15+
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n/an/a 5.31n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113558
PNG
(US8633204, 295)
Show SMILES Cc1nc(N)nc2n([C@@H]3CC[C@@H](CC3)OCCO)c(=O)c(cc12)-c1cnc2ccccc2c1
Show InChI InChI=1S/C25H27N5O3/c1-15-20-13-21(17-12-16-4-2-3-5-22(16)27-14-17)24(32)30(23(20)29-25(26)28-15)18-6-8-19(9-7-18)33-11-10-31/h2-5,12-14,18-19,31H,6-11H2,1H3,(H2,26,28,29)/t18-,19+
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n/an/a 52.9n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113562
PNG
(US8633204, 300)
Show SMILES COc1ccc(cn1)-c1cc2c(C)nc(N)nc2n([C@H]2CC[C@@H](CC2)OC[C@@H](O)CO)c1=O
Show InChI InChI=1S/C23H29N5O5/c1-13-18-9-19(14-3-8-20(32-2)25-10-14)22(31)28(21(18)27-23(24)26-13)15-4-6-17(7-5-15)33-12-16(30)11-29/h3,8-10,15-17,29-30H,4-7,11-12H2,1-2H3,(H2,24,26,27)/t15-,16-,17-/m0/s1
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n/an/a 6.82n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113564
PNG
(US8633204, 302)
Show SMILES Cc1nc(N)nc2n([C@H]3CC[C@@H](CC3)OCCO)c(=O)c(cc12)-c1cnn(C)c1
Show InChI InChI=1S/C20H26N6O3/c1-12-16-9-17(13-10-22-25(2)11-13)19(28)26(18(16)24-20(21)23-12)14-3-5-15(6-4-14)29-8-7-27/h9-11,14-15,27H,3-8H2,1-2H3,(H2,21,23,24)/t14-,15-
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n/an/a 22.3n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50433044
PNG
(CHEMBL2375963 | US8633204, 304)
Show SMILES COc1ncc(cc1F)-c1cc2c(C)nc(N)nc2n([C@@H]2CC[C@@H](CC2)OCC(N)=O)c1=O
Show InChI InChI=1S/C22H25FN6O4/c1-11-15-8-16(12-7-17(23)20(32-2)26-9-12)21(31)29(19(15)28-22(25)27-11)13-3-5-14(6-4-13)33-10-18(24)30/h7-9,13-14H,3-6,10H2,1-2H3,(H2,24,30)(H2,25,27,28)/t13-,14+
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n/an/a 1.58n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50433041
PNG
(CHEMBL2375960 | US8633204, 306)
Show SMILES Cc1nc(N)nc2n([C@@H]3CC[C@@H](CC3)OCC(N)=O)c(=O)c(cc12)-c1cnn(C)c1
Show InChI InChI=1S/C20H25N7O3/c1-11-15-7-16(12-8-23-26(2)9-12)19(29)27(18(15)25-20(22)24-11)13-3-5-14(6-4-13)30-10-17(21)28/h7-9,13-14H,3-6,10H2,1-2H3,(H2,21,28)(H2,22,24,25)/t13-,14+
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n/an/a 58.1n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50433040
PNG
(CHEMBL2375959 | US8633204, 308)
Show SMILES Cc1nc(N)nc2n([C@@H]3CC[C@@H](CC3)OCC(N)=O)c(=O)c(cc12)-c1cnc2ccccc2c1
Show InChI InChI=1S/C25H26N6O3/c1-14-19-11-20(16-10-15-4-2-3-5-21(15)28-12-16)24(33)31(23(19)30-25(27)29-14)17-6-8-18(9-7-17)34-13-22(26)32/h2-5,10-12,17-18H,6-9,13H2,1H3,(H2,26,32)(H2,27,29,30)/t17-,18+
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n/an/a 17.7n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50433037
PNG
(CHEMBL2375956 | US8633204, 311)
Show SMILES COc1ncc(cn1)-c1cc2c(C)nc(N)nc2n([C@H]2CC[C@@H](CC2)OCC(N)=O)c1=O
Show InChI InChI=1S/C21H25N7O4/c1-11-15-7-16(12-8-24-21(31-2)25-9-12)19(30)28(18(15)27-20(23)26-11)13-3-5-14(6-4-13)32-10-17(22)29/h7-9,13-14H,3-6,10H2,1-2H3,(H2,22,29)(H2,23,26,27)/t13-,14-
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n/an/a 4.11n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50433035
PNG
(CHEMBL2375954 | US8633204, 313)
Show SMILES Cc1nc(N)nc2n([C@H]3CC[C@@H](CC3)OCC(N)=O)c(=O)c(cc12)-c1cnn(C)c1
Show InChI InChI=1S/C20H25N7O3/c1-11-15-7-16(12-8-23-26(2)9-12)19(29)27(18(15)25-20(22)24-11)13-3-5-14(6-4-13)30-10-17(21)28/h7-9,13-14H,3-6,10H2,1-2H3,(H2,21,28)(H2,22,24,25)/t13-,14-
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n/an/a 47.9n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113570
PNG
(US8633204, 317)
Show SMILES COc1ccc(cn1)-c1cc2c(C)nc(N)nc2n([C@H]2C[C@@H](C2)OCC(N)=O)c1=O
Show InChI InChI=1S/C20H22N6O4/c1-10-14-7-15(11-3-4-17(29-2)23-8-11)19(28)26(18(14)25-20(22)24-10)12-5-13(6-12)30-9-16(21)27/h3-4,7-8,12-13H,5-6,9H2,1-2H3,(H2,21,27)(H2,22,24,25)/t12-,13-
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n/an/a 4.72n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM113572
PNG
(US8633204, 319)
Show SMILES COc1ncc(cn1)-c1cc2c(C)nc(N)nc2n([C@H]2C[C@@H](C2)OCC(N)=O)c1=O
Show InChI InChI=1S/C19H21N7O4/c1-9-13-5-14(10-6-22-19(29-2)23-7-10)17(28)26(16(13)25-18(21)24-9)11-3-12(4-11)30-8-15(20)27/h5-7,11-12H,3-4,8H2,1-2H3,(H2,20,27)(H2,21,24,25)/t11-,12-
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n/an/a 5.91n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...


US Patent US8633204 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BQT
More data for this
Ligand-Target Pair
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