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Found 5214 hits Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM179273
PNG
(US9126948, 13)
Show SMILES COc1c(cc(Cl)c(Cl)c1-c1ccc(cc1)S(C)(=O)=O)C(C)Nc1ncnc(N)c1C#N
Show InChI InChI=1S/C21H19Cl2N5O3S/c1-11(28-21-15(9-24)20(25)26-10-27-21)14-8-16(22)18(23)17(19(14)31-2)12-4-6-13(7-5-12)32(3,29)30/h4-8,10-11H,1-3H3,(H3,25,26,27,28)
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US Patent
n/an/a<20n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9126948 (2015)


BindingDB Entry DOI: 10.7270/Q2P849NB
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM179274
PNG
(US9126948, 14)
Show SMILES COc1c(cc(Cl)c(Cl)c1-c1cnc(N)nc1)C(C)Nc1ncnc(N)c1C#N
Show InChI InChI=1S/C18H16Cl2N8O/c1-8(28-17-11(4-21)16(22)26-7-27-17)10-3-12(19)14(20)13(15(10)29-2)9-5-24-18(23)25-6-9/h3,5-8H,1-2H3,(H2,23,24,25)(H3,22,26,27,28)
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US Patent
n/an/a<20n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9126948 (2015)


BindingDB Entry DOI: 10.7270/Q2P849NB
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM161572
PNG
(US9108983, Example 387 | US9108984, 1)
Show SMILES CC(Nc1ncnc(N)c1C#N)c1cc(Cl)c2ccnnc2c1-c1cccc(F)c1
Show InChI InChI=1S/C21H15ClFN7/c1-11(29-21-16(9-24)20(25)26-10-27-21)15-8-17(22)14-5-6-28-30-19(14)18(15)12-3-2-4-13(23)7-12/h2-8,10-11H,1H3,(H3,25,26,27,29)
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n/an/a<20n/an/an/an/a6.725



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9108984 (2015)


BindingDB Entry DOI: 10.7270/Q2JM28CS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM161573
PNG
(US9108983, Example 388 | US9108984, 2)
Show SMILES CN1CCc2cc(cnc12)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n(C)c1C)c1ccc(O)cc1
Show InChI InChI=1S/C42H43ClN6O4/c1-27-37(42(52)49(32-9-11-35(50)12-10-32)33-21-29-14-15-45(2)40(29)44-24-33)23-39(46(27)3)38-22-31(43)8-13-36(38)41(51)48-25-30-7-5-4-6-28(30)20-34(48)26-47-16-18-53-19-17-47/h4-13,21-24,34,50H,14-20,25-26H2,1-3H3/t34-/m0/s1
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n/an/a<20n/an/an/an/a6.725



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9108984 (2015)


BindingDB Entry DOI: 10.7270/Q2JM28CS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261120
PNG
((2S)-1-(3-{3-[1-(4-Amino-3- methyl-1H-pyrazolo[3,4...)
Show SMILES CCOc1c(cc(Cl)c(F)c1C1CN(C[C@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H28ClFN6O2/c1-5-32-20-15(13(4)30-22-17(12(3)28-30)21(25)26-10-27-22)6-16(23)19(24)18(20)14-8-29(9-14)7-11(2)31/h6,10-11,13-14,31H,5,7-9H2,1-4H3,(H2,25,26,27)/t11-,13?/m0/s1
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261171
PNG
(US10092570, Example 194 | US9707233, 194 | {3-[1-(...)
Show SMILES COc1c(CC#N)c(C)c(Cl)cc1C(C)Nc1ncnc(N)c1C(C)=N
Show InChI InChI=1S/C18H21ClN6O/c1-9-12(5-6-20)16(26-4)13(7-14(9)19)11(3)25-18-15(10(2)21)17(22)23-8-24-18/h7-8,11,21H,5H2,1-4H3,(H3,22,23,24,25)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM289238
PNG
(US10092570, Example 239)
Show SMILES CCOc1c(cc(Cl)c([N+]#[C-])c1C1CN(C1)C(C)(C)C(N)=O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H29ClN8O2/c1-7-35-20-15(13(3)33-22-17(12(2)31-33)21(26)29-11-30-22)8-16(25)19(28-6)18(20)14-9-32(10-14)24(4,5)23(27)34/h8,11,13-14H,7,9-10H2,1-5H3,(H2,27,34)(H2,26,29,30)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261260
PNG
(US10092570, Example 283 | US9707233, 283)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C1)C(=O)C(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H26ClN7O2/c1-11(2)23(32)30-8-14(9-30)19-16(7-25)17(24)6-15(20(19)33-5)13(4)31-22-18(12(3)29-31)21(26)27-10-28-22/h6,10-11,13-14H,8-9H2,1-5H3,(H2,26,27,28)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM255834
PNG
(4-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1-c1cncc(c1)S(C)(=O)=O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H22ClN7O3S/c1-5-34-21-16(13(3)31-23-19(12(2)30-31)22(26)28-11-29-23)7-18(24)17(8-25)20(21)14-6-15(10-27-9-14)35(4,32)33/h6-7,9-11,13H,5H2,1-4H3,(H2,26,28,29)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM255844
PNG
(5-{3-[1-(4-amino-3-cyclopropyl-1H-pyrazolo[3,4-d]p...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C2CC2)c2c(N)ncnc12
Show InChI InChI=1S/C27H30ClN7O2/c1-6-37-24-18(15(3)35-26-22(25(29)31-13-32-26)23(33-35)16-7-8-16)11-19(28)14(2)21(24)17-9-10-20(30-12-17)27(36)34(4)5/h9-13,15-16H,6-8H2,1-5H3,(H2,29,31,32)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM255851
PNG
(5-{3-[1-(4-amino-3-pyridin-4-yl-1H-pyrazolo[3,4-d]...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(-c2ccncc2)c2c(N)ncnc12
Show InChI InChI=1S/C29H29ClN8O2/c1-6-40-26-20(13-21(30)16(2)23(26)19-7-8-22(33-14-19)29(39)37(4)5)17(3)38-28-24(27(31)34-15-35-28)25(36-38)18-9-11-32-12-10-18/h7-15,17H,6H2,1-5H3,(H2,31,34,35)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM289110
PNG
(2-(3-{3-[1-(4-Amino-3-methyl- 1H-pyrazolo[3,4-d]py...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(CC(O)=O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H25ClN6O3/c1-10-15(22)5-14(19(31-4)17(10)13-6-27(7-13)8-16(29)30)12(3)28-21-18(11(2)26-28)20(23)24-9-25-21/h5,9,12-13H,6-8H2,1-4H3,(H,29,30)(H2,23,24,25)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261089
PNG
(1-(1-{5-Chloro-3-[1-(2,2- difluoroethyl)azetidin-3...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(CC(F)F)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H25ClF2N6O/c1-10-15(22)5-14(19(31-4)17(10)13-6-29(7-13)8-16(23)24)12(3)30-21-18(11(2)28-30)20(25)26-9-27-21/h5,9,12-13,16H,6-8H2,1-4H3,(H2,25,26,27)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261090
PNG
(2-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyr...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C(CO)C(F)(F)F)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H26ClF3N6O2/c1-10-15(23)5-14(12(3)32-21-18(11(2)30-32)20(27)28-9-29-21)19(34-4)17(10)13-6-31(7-13)16(8-33)22(24,25)26/h5,9,12-13,16,33H,6-8H2,1-4H3,(H2,27,28,29)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261091
PNG
(1-(1-{5-Chloro-3-[1-(2-fluoro-1- methylethyl)azeti...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C(C)CF)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H28ClFN6O/c1-11(7-24)29-8-15(9-29)18-12(2)17(23)6-16(20(18)31-5)14(4)30-22-19(13(3)28-30)21(25)26-10-27-22/h6,10-11,14-15H,7-9H2,1-5H3,(H2,25,26,27)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261092
PNG
((2R)-3-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C[C@@H](O)C(F)(F)F)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H26ClF3N6O2/c1-10-15(23)5-14(12(3)32-21-18(11(2)30-32)20(27)28-9-29-21)19(34-4)17(10)13-6-31(7-13)8-16(33)22(24,25)26/h5,9,12-13,16,33H,6-8H2,1-4H3,(H2,27,28,29)/t12?,16-/m1/s1
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261093
PNG
((2S)-3-(3-{3-[1-(4-Amino-3- methyl-1H-pyrazolo[3,4...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C[C@H](O)C(F)(F)F)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H26ClF3N6O2/c1-10-15(23)5-14(12(3)32-21-18(11(2)30-32)20(27)28-9-29-21)19(34-4)17(10)13-6-31(7-13)8-16(33)22(24,25)26/h5,9,12-13,16,33H,6-8H2,1-4H3,(H2,27,28,29)/t12?,16-/m0/s1
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261094
PNG
(1-[1-(5-Chloro-2-methoxy-4-methyl-3-{1-[(1-methyl-...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C(=O)c1cnn(C)c1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H27ClN8O2/c1-12-18(25)6-17(14(3)33-23-20(13(2)30-33)22(26)27-11-28-23)21(35-5)19(12)16-9-32(10-16)24(34)15-7-29-31(4)8-15/h6-8,11,14,16H,9-10H2,1-5H3,(H2,26,27,28)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261095
PNG
((2S)-1-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C(=O)[C@H](C)O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H27ClN6O3/c1-10-16(23)6-15(12(3)29-21-18(11(2)27-29)20(24)25-9-26-21)19(32-5)17(10)14-7-28(8-14)22(31)13(4)30/h6,9,12-14,30H,7-8H2,1-5H3,(H2,24,25,26)/t12?,13-/m0/s1
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261096
PNG
(1-(1-{5-Chloro-3-[1- (cyclopropylcarbonyl)azetidin...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C(=O)C1CC1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H27ClN6O2/c1-11-17(24)7-16(13(3)30-22-19(12(2)28-30)21(25)26-10-27-22)20(32-4)18(11)15-8-29(9-15)23(31)14-5-6-14/h7,10,13-15H,5-6,8-9H2,1-4H3,(H2,25,26,27)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261097
PNG
(1-[1-(5-Chloro-2-methoxy-4- methyl-3-{1-[(5-methyl...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C(=O)c1cnoc1C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H26ClN7O3/c1-11-18(25)6-16(13(3)32-23-20(12(2)30-32)22(26)27-10-28-23)21(34-5)19(11)15-8-31(9-15)24(33)17-7-29-35-14(17)4/h6-7,10,13,15H,8-9H2,1-5H3,(H2,26,27,28)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261098
PNG
((2R)-1-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C(=O)[C@@H](C)O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H27ClN6O3/c1-10-16(23)6-15(12(3)29-21-18(11(2)27-29)20(24)25-9-26-21)19(32-5)17(10)14-7-28(8-14)22(31)13(4)30/h6,9,12-14,30H,7-8H2,1-5H3,(H2,24,25,26)/t12?,13-/m1/s1
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261099
PNG
(1-[(3-{3-[1-(4-Amino-3-methyl- 1H-pyrazolo[3,4-d]p...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C(=O)C1(O)CC1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H27ClN6O3/c1-11-16(24)7-15(13(3)30-21-18(12(2)28-30)20(25)26-10-27-21)19(33-4)17(11)14-8-29(9-14)22(31)23(32)5-6-23/h7,10,13-14,32H,5-6,8-9H2,1-4H3,(H2,25,26,27)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261100
PNG
(1-(3-{3-[1-(4-Amino-3-methyl-1H- pyrazolo[3,4-d]py...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C(=O)C(C)(C)O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H29ClN6O3/c1-11-16(24)7-15(13(3)30-21-18(12(2)28-30)20(25)26-10-27-21)19(33-6)17(11)14-8-29(9-14)22(31)23(4,5)32/h7,10,13-14,32H,8-9H2,1-6H3,(H2,25,26,27)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261101
PNG
(1-(1-{5-Chloro-2-methoxy-4- methyl-3-[1-(1H-pyrazo...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C(=O)c1cn[nH]c1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H25ClN8O2/c1-11-17(24)5-16(13(3)32-22-19(12(2)30-32)21(25)26-10-27-22)20(34-4)18(11)15-8-31(9-15)23(33)14-6-28-29-7-14/h5-7,10,13,15H,8-9H2,1-4H3,(H,28,29)(H2,25,26,27)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261102
PNG
(US10092570, Example 125 | US9707233, 125 | [3-(3-{...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(CC#N)C1)C(C)n1nc(-c2cnn(C)c2)c2c(N)ncnc12
Show InChI InChI=1S/C24H26ClN9O/c1-13-18(25)7-17(22(35-4)19(13)16-10-33(11-16)6-5-26)14(2)34-24-20(23(27)28-12-29-24)21(31-34)15-8-30-32(3)9-15/h7-9,12,14,16H,6,10-11H2,1-4H3,(H2,27,28,29)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261103
PNG
(US10092570, Example 126 | US9707233, 126 | [3-(3-{...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(CC#N)C1)C(C)n1nc(-c2cn[nH]c2)c2c(N)ncnc12
Show InChI InChI=1S/C23H24ClN9O/c1-12-17(24)6-16(21(34-3)18(12)15-9-32(10-15)5-4-25)13(2)33-23-19(22(26)27-11-28-23)20(31-33)14-7-29-30-8-14/h6-8,11,13,15H,5,9-10H2,1-3H3,(H,29,30)(H2,26,27,28)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261104
PNG
(1-{1-[5-Chloro-3-(1-isopropylazetidin-3-yl)-2-meth...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C(C)C)C(C)n1nc(C(F)F)c2c(N)ncnc12
Show InChI InChI=1S/C22H27ClF2N6O/c1-10(2)30-7-13(8-30)16-11(3)15(23)6-14(19(16)32-5)12(4)31-22-17(18(29-31)20(24)25)21(26)27-9-28-22/h6,9-10,12-13,20H,7-8H2,1-5H3,(H2,26,27,28)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261105
PNG
(5-{1-[4-amino-3-(difluoromethyl)-1H-pyrazolo[3,4-d...)
Show SMILES COc1c(cc(C#N)c(C)c1C1CN(C1)C(C)C)C(C)n1nc(C(F)F)c2c(N)ncnc12
Show InChI InChI=1S/C23H27F2N7O/c1-11(2)31-8-15(9-31)17-12(3)14(7-26)6-16(20(17)33-5)13(4)32-23-18(19(30-32)21(24)25)22(27)28-10-29-23/h6,10-11,13,15,21H,8-9H2,1-5H3,(H2,27,28,29)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM289128
PNG
(US10092570, Example 129)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(CC(F)(F)F)C1)C(C)n1nc(C(F)F)c2c(N)ncnc12
Show InChI InChI=1S/C21H22ClF5N6O/c1-9-13(22)4-12(17(34-3)14(9)11-5-32(6-11)7-21(25,26)27)10(2)33-20-15(16(31-33)18(23)24)19(28)29-8-30-20/h4,8,10-11,18H,5-7H2,1-3H3,(H2,28,29,30)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM289129
PNG
(US10092570, Example 130)
Show SMILES COc1c(cc([N+]#[C-])c(C)c1C1CN(CCO)C1)C(C)n1nc(C(F)F)c2c(N)ncnc12
Show InChI InChI=1S/C22H25F2N7O2/c1-11-15(26-3)7-14(19(33-4)16(11)13-8-30(9-13)5-6-32)12(2)31-22-17(18(29-31)20(23)24)21(25)27-10-28-22/h7,10,12-13,20,32H,5-6,8-9H2,1-2,4H3,(H2,25,27,28)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM289130
PNG
(US10092570, Example 131 | US10092570, Example 137)
Show SMILES COc1c(cc([N+]#[C-])c(C)c1C1CN(C[C@H](C)O)C1)C(C)n1nc(C(F)F)c2c(N)ncnc12
Show InChI InChI=1S/C23H27F2N7O2/c1-11(33)7-31-8-14(9-31)17-12(2)16(27-4)6-15(20(17)34-5)13(3)32-23-18(19(30-32)21(24)25)22(26)28-10-29-23/h6,10-11,13-14,21,33H,7-9H2,1-3,5H3,(H2,26,28,29)/t11-,13?/m0/s1
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261109
PNG
(US10092570, Example 132 | US9707233, 132)
Show SMILES COc1c(cc(C#N)c(C)c1C1CN(C[C@@H](C)O)C1)C(C)n1nc(C(F)F)c2c(N)ncnc12
Show InChI InChI=1S/C23H27F2N7O2/c1-11(33)7-31-8-15(9-31)17-12(2)14(6-26)5-16(20(17)34-4)13(3)32-23-18(19(30-32)21(24)25)22(27)28-10-29-23/h5,10-11,13,15,21,33H,7-9H2,1-4H3,(H2,27,28,29)/t11-,13?/m1/s1
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM289132
PNG
(US10092570, Example 133)
Show SMILES COc1c(cc([N+]#[C-])c(C)c1C1CN(CC(C)(C)O)C1)C(C)n1nc(C(F)F)c2c(N)ncnc12
Show InChI InChI=1S/C24H29F2N7O2/c1-12-16(28-5)7-15(20(35-6)17(12)14-8-32(9-14)10-24(3,4)34)13(2)33-23-18(19(31-33)21(25)26)22(27)29-11-30-23/h7,11,13-14,21,34H,8-10H2,1-4,6H3,(H2,27,29,30)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM289133
PNG
(US10092570, Example 134)
Show SMILES CNC(=O)[C@H](C)N1CC(C1)c1c(C)c(cc(C(C)n2nc(C(F)F)c3c(N)ncnc23)c1OC)[N+]#[C-]
Show InChI InChI=1S/C24H28F2N8O2/c1-11-16(28-4)7-15(20(36-6)17(11)14-8-33(9-14)13(3)24(35)29-5)12(2)34-23-18(19(32-34)21(25)26)22(27)30-10-31-23/h7,10,12-14,21H,8-9H2,1-3,5-6H3,(H,29,35)(H2,27,30,31)/t12?,13-/m0/s1
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261112
PNG
(US10092570, Example 135 | US9707233, 135)
Show SMILES CNC(=O)[C@@H](C)N1CC(C1)c1c(C)c(cc(C(C)n2nc(C(F)F)c3c(N)ncnc23)c1OC)C#N
Show InChI InChI=1S/C24H28F2N8O2/c1-11-14(7-27)6-16(20(36-5)17(11)15-8-33(9-15)13(3)24(35)29-4)12(2)34-23-18(19(32-34)21(25)26)22(28)30-10-31-23/h6,10,12-13,15,21H,8-9H2,1-5H3,(H,29,35)(H2,28,30,31)/t12?,13-/m1/s1
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM289135
PNG
(US10092570, Example 136)
Show SMILES COc1c(cc([N+]#[C-])c(C)c1C1CN(CC(F)F)C1)C(C)n1nc(C(F)F)c2c(N)ncnc12
Show InChI InChI=1S/C22H23F4N7O/c1-10-14(28-3)5-13(19(34-4)16(10)12-6-32(7-12)8-15(23)24)11(2)33-22-17(18(31-33)20(25)26)21(27)29-9-30-22/h5,9,11-12,15,20H,6-8H2,1-2,4H3,(H2,27,29,30)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM246853
PNG
(4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...)
Show SMILES C[C@H](NC(=O)c1cc(F)c(cc1F)N1CC(CC#N)(C1)n1cc(cn1)-c1c(C)n[nH]c1C)C(F)(F)F
Show InChI InChI=1S/C23H22F5N7O/c1-12-20(13(2)33-32-12)15-8-30-35(9-15)22(4-5-29)10-34(11-22)19-7-17(24)16(6-18(19)25)21(36)31-14(3)23(26,27)28/h6-9,14H,4,10-11H2,1-3H3,(H,31,36)(H,32,33)/t14-/m0/s1
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10077277 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM246853
PNG
(4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...)
Show SMILES C[C@H](NC(=O)c1cc(F)c(cc1F)N1CC(CC#N)(C1)n1cc(cn1)-c1c(C)n[nH]c1C)C(F)(F)F
Show InChI InChI=1S/C23H22F5N7O/c1-12-20(13(2)33-32-12)15-8-30-35(9-15)22(4-5-29)10-34(11-22)19-7-17(24)16(6-18(19)25)21(36)31-14(3)23(26,27)28/h6-9,14H,4,10-11H2,1-3H3,(H,31,36)(H,32,33)/t14-/m0/s1
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n/an/a 250n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10077277 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM246861
PNG
(3-[1-(6- chloropyridin-2- yl)pyrrolidin-3-yl]-3- [...)
Show SMILES Clc1cccc(n1)N1CCC(C1)C(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C21H19ClN8/c22-18-2-1-3-19(28-18)29-9-6-14(11-29)17(4-7-23)30-12-15(10-27-30)20-16-5-8-24-21(16)26-13-25-20/h1-3,5,8,10,12-14,17H,4,6,9,11H2,(H,24,25,26)
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10077277 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM246864
PNG
(3-(1- [1,3]oxazolo[5,4- b]pyridin-2- ylpyrrolidin-...)
Show SMILES N#CCC(C1CCN(C1)c1nc2cccnc2o1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C22H19N9O/c23-6-3-18(14-5-9-30(11-14)22-29-17-2-1-7-25-21(17)32-22)31-12-15(10-28-31)19-16-4-8-24-20(16)27-13-26-19/h1-2,4,7-8,10,12-14,18H,3,5,9,11H2,(H,24,26,27)
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...


US Patent US10077277 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM255856
PNG
(5-{3-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cncc(c1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H26ClN7O2/c1-12-18(25)8-17(14(3)32-23-20(13(2)30-32)22(26)28-11-29-23)21(34-6)19(12)15-7-16(10-27-9-15)24(33)31(4)5/h7-11,14H,1-6H3,(H2,26,28,29)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM255800
PNG
(5-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H26ClN7O2/c1-12-17(25)9-16(14(3)32-23-20(13(2)30-32)22(26)28-11-29-23)21(34-6)19(12)15-7-8-18(27-10-15)24(33)31(4)5/h7-11,14H,1-6H3,(H2,26,28,29)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM255802
PNG
(1-{1-[5-Chloro-4-fluoro-3-(1-isopropylazetidin-3-y...)
Show SMILES COc1c(cc(Cl)c(F)c1C1CN(C1)C(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H26ClFN6O/c1-10(2)28-7-13(8-28)17-18(23)15(22)6-14(19(17)30-5)12(4)29-21-16(11(3)27-29)20(24)25-9-26-21/h6,9-10,12-13H,7-8H2,1-5H3,(H2,24,25,26)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM255859
PNG
(US10092570, Example 68 | US9707233, 68 (1st peak))
Show SMILES COc1c(cc(Cl)c(F)c1C1CN(C[C@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H26ClFN6O2/c1-10(30)6-28-7-13(8-28)17-18(23)15(22)5-14(19(17)31-4)12(3)29-21-16(11(2)27-29)20(24)25-9-26-21/h5,9-10,12-13,30H,6-8H2,1-4H3,(H2,24,25,26)/t10-,12?/m0/s1
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM255860
PNG
((2R)-1-(3-{3-[1-(4-Amino-3- methyl-1H-pyrazolo[3,4...)
Show SMILES COc1c(cc(Cl)c(F)c1C1CN(C[C@@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H26ClFN6O2/c1-10(30)6-28-7-13(8-28)17-18(23)15(22)5-14(19(17)31-4)12(3)29-21-16(11(2)27-29)20(24)25-9-26-21/h5,9-10,12-13,30H,6-8H2,1-4H3,(H2,24,25,26)/t10-,12?/m1/s1
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM255861
PNG
(1-(3-{3-[1-(4-Amino-3-methyl-1H- pyrazolo[3,4-d]py...)
Show SMILES COc1c(cc(Cl)c(F)c1C1CN(CC(C)(C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H28ClFN6O2/c1-11-16-20(25)26-10-27-21(16)30(28-11)12(2)14-6-15(23)18(24)17(19(14)32-5)13-7-29(8-13)9-22(3,4)31/h6,10,12-13,31H,7-9H2,1-5H3,(H2,25,26,27)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM255862
PNG
(2-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyr...)
Show SMILES COc1c(cc(Cl)c(F)c1C1CN(CCO)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H24ClFN6O2/c1-10-15-19(23)24-9-25-20(15)28(26-10)11(2)13-6-14(21)17(22)16(18(13)30-3)12-7-27(8-12)4-5-29/h6,9,11-12,29H,4-5,7-8H2,1-3H3,(H2,23,24,25)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM255863
PNG
(1-{1-[5-Chloro-4-fluoro-2-methoxy-3-(1-oxetan-3-yl...)
Show SMILES COc1c(cc(Cl)c(F)c1C1CN(C)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C19H22ClFN6O/c1-9-14-18(22)23-8-24-19(14)27(25-9)10(2)12-5-13(20)16(21)15(17(12)28-4)11-6-26(3)7-11/h5,8,10-11H,6-7H2,1-4H3,(H2,22,23,24)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM255864
PNG
(1-{1-[5-Chloro-4-fluoro-3-(1-isopropylazetidin-3-y...)
Show SMILES COc1c(cc(Cl)c(F)c1C1CN(C1)C(C)C)C(C)n1nc(C(F)F)c2c(N)ncnc12
Show InChI InChI=1S/C21H24ClF3N6O/c1-9(2)30-6-11(7-30)14-16(23)13(22)5-12(18(14)32-4)10(3)31-21-15(17(29-31)19(24)25)20(26)27-8-28-21/h5,8-11,19H,6-7H2,1-4H3,(H2,26,27,28)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
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